[
    {
        "uniprot_canonical_ac": "Q9H790-1",
        "uniprot_id": [
            {
                "id": "EXO5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H790",
                "type": "external"
            }
        ],
        "mass": 41816.0,
        "length": 373,
        "protein_name": "Exonuclease V",
        "gene_name": "EXO5",
        "organism": "Human",
        "refseq_name": "exonuclease V",
        "refseq_ac": [
            {
                "id": "NP_001333875",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333875",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EXO5; C1orf176; DEM1",
        "gene_names_refseq": "C1orf176; DEM1; EXO5; Exo V; hExo5",
        "protein_names_uniprotkb": "Exonuclease V; 3.1.-.-; Defects in morphology protein 1 homolog; Exo V; hExo5",
        "protein_names_refseq": "defects in morphology 1 homolog; defects in morphology protein 1 homolog; exonuclease V; probable exonuclease V",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64789)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "11237011;15302935;23095756;26992070;28228285;28832583;29242379;29557506;29761480;30315122;30524438;31530632;31563844;31616062;31844290;32161166;32387766;33691108;33968037;34197737;34509645;35051231;35580925;36010968",
        "class_list": "",
        "function": "EXO5-DNA structure and BLM interactions direct DNA resection critical for ATR-dependent replication restart., [RefSeq, PubMed]; Functional deficiency of DNA repair gene EXO5 results in androgen-induced genomic instability and prostate tumorigenesis., [RefSeq, PubMed]; Single-stranded DNA (ssDNA) bidirectional exonuclease involved in DNA repair. Probably involved in DNA repair following ultraviolet (UV) irradiation and interstrand cross-links (ICLs) damage. Has both 5'-3' and 3'-5' exonuclease activities with a strong preference for 5'-ends. Acts as a sliding exonuclease that loads at ssDNA ends and then slides along the ssDNA prior to cutting; however the sliding and the 3'-5' exonuclease activities are abolished upon binding to the replication protein A (RPA) complex that enforces 5'-directionality activity., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; The human homolog (C1orf176; EXO5) that functions in the repair of nuclear DNA damage., [RefSeq, PubMed]; The protein encoded by this gene is a single-stranded DNA (ssDNA)-specific exonuclease that can slide along the DNA before cutting it. However, human replication protein A binds ssDNA and restricts sliding of the encoded protein, providing a 5'-directionality to the enzyme. This protein localizes to nuclear repair loci after DNA damage. [provided by RefSeq, Nov 2016]., [RefSeq]; Three of them [PLEC (OR = 6.28, p = 6.42 x 10(-23) ) (p.Arg2016Trp), EXO5 (OR = 3.37, p = 4.82 x 10(-09) ) (p.Arg344AlafsTer10) and DNAH7 (OR = 1.64, p = 0.048)] were replicated as potential candidates., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DPV4;Q5SWM7;Q5SWM8;Q5SWM9;Q5SWN0;Q5SWN1;Q8WTW9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008310 single-stranded DNA 3'-5' DNA exonuclease activity;GO:0003677 DNA binding;GO:0046872 metal ion binding;GO:0051539 4 iron, 4 sulfur cluster binding;GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0036297 interstrand cross-link repair;GO:0006281 DNA repair",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q9H790-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P10746-1",
        "uniprot_id": [
            {
                "id": "HEM4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P10746",
                "type": "external"
            }
        ],
        "mass": 28628.0,
        "length": 265,
        "protein_name": "Uroporphyrinogen-III synthase",
        "gene_name": "UROS",
        "organism": "Human",
        "refseq_name": "uroporphyrinogen-III synthase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_000366",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000366",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UROS",
        "gene_names_refseq": "Mgu; UROIIIS; UROS",
        "protein_names_uniprotkb": "Uroporphyrinogen-III synthase; 4.2.1.75; Hydroxymethylbilane hydrolyase [cyclizing]; UROIIIS; UROS; Uroporphyrinogen-III cosynthase",
        "protein_names_refseq": "hydroxymethylbilane hydrolyase; uroporphyrinogen-III cosynthase; uroporphyrinogen-III synthase isoform 2",
        "tax_id": 9606,
        "disease": "erythropoietic protoporphyria (Disease Ontology:DOID:13270); cutaneous porphyria (Disease Ontology:DOID:13271)",
        "pathway": " (hsa:7390);  (R-HSA-189451)",
        "pathway_count": 2,
        "publication_count": 60,
        "publication_id_list": "10706561;11032836;11032841;11112350;11121156;11175906;11237011;11689424;12060141;12474143;12773194;15235026;15304101;15863660;16121195;16176984;16258391;1733834;1737856;18004775;1939222;20705604;21570665;21653323;22350154;2331520;23467411;25576301;28334762;28904123;30379171;30454868;3174619;31844290;32157095;32502341;33141586;33592498;33968037;34019948;35051231;35580925;36010968;3805019;666752;6822570;7354069;7592565;7860775;8078902;8159699;8644733;8655129;8771201;8829650;9177788;9188670;9803266;9834209;9878253",
        "class_list": "",
        "function": "A, T to C change at nucleotide 34313, leading to a substitution of Leucine by Proline at codon 237, was observed in the homozygous state in a family with congenital erythropoietic porphyria., [RefSeq, PubMed]; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins (PubMed:11689424, PubMed:18004775). Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (PubMed:11689424, PubMed:18004775)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; REVIEW: Structural, thermodynamic, and mechanistical studies in uroporphyrinogen III synthase and molecular basis of congenital erythropoietic porphyria Review article, [RefSeq, PubMed]; The protein encoded by this gene catalyzes the fourth step of porphyrin biosynthesis in the heme biosynthetic pathway. Defects in this gene cause congenital erythropoietic porphyria (Gunther's disease). [provided by RefSeq, Jul 2008]., [RefSeq]; These results expand the molecular heterogeneity of the erythropoietic porphyrias by adding a total of 7 novel mutations in uroporphyrinogen III synthase., [RefSeq, PubMed]; We show evidence that abnormal protein homeostasis is a prevalent mechanism responsible for UROS deficiency and that modulators of UROS proteolysis such as proteasome inhibitors or chemical chaperones may represent an attractive therapeutic option to reduce porphyrin accumulation and prevent skin photosensitivity in Congenital erythropoietic porphyria (CEP)patients when the genotype includes a missense variant., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RC13;D3DRF7;Q9H2T1",
        "ec_number_list": [
            {
                "id": "4.2.1.75",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.75",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005542 folic acid binding;GO:0004852 uroporphyrinogen-III synthase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process;GO:0070541 response to platinum ion;GO:0071243 cellular response to arsenic-containing substance;GO:0006784 heme A biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "P10746-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TES7-1",
        "uniprot_id": [
            {
                "id": "FBF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TES7",
                "type": "external"
            }
        ],
        "mass": 125446.0,
        "length": 1133,
        "protein_name": "Fas-binding factor 1",
        "gene_name": "FBF1",
        "organism": "Human",
        "refseq_name": "fas-binding factor 1",
        "refseq_ac": [
            {
                "id": "NP_001306122",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001306122",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FBF1; ALB; KIAA1863",
        "gene_names_refseq": "Alb; FBF-1; FBF1",
        "protein_names_uniprotkb": "Fas-binding factor 1; FBF-1; Protein albatross",
        "protein_names_refseq": "Fas (TNFRSF6) binding factor 1; Fas binding protein 1; albatross; fas-binding factor 1; protein albatross",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:85302);  (R-HSA-5620912)",
        "pathway_count": 2,
        "publication_count": 65,
        "publication_id_list": "10978533;11237011;16357211;17574030;17646400;17719545;18037885;18694559;18801063;18838552;19004860;19081074;19615748;19940019;20230748;20308558;20399632;20558667;21273506;21399614;21422230;21548880;21565611;21620453;21725307;21792235;22179047;22424782;22433857;22653444;23141531;23141541;23186163;23253480;23348840;23400999;23530209;23747070;23769972;23789104;24053599;24089205;24231678;24469809;24982133;25047611;25313408;26992070;27583843;27846572;28834231;29242379;29557506;30318703;31467083;31844290;32157095;32357974;32387766;32938616;33968037;34171305;34348145;34509645;35051231",
        "class_list": "",
        "function": "Albatross is a novel protein that spatiotemporally integrates different aspects of centrosome function, namely ciliogenesis, centriole duplication, and centrosome separation., [RefSeq, PubMed]; FBF1 deficiency promotes beiging and healthy expansion of white adipose tissue., [RefSeq, PubMed]; Keratin-binding protein required for epithelial cell polarization. Involved in apical junction complex (AJC) assembly via its interaction with PARD3. Required for ciliogenesis., [UniProtKB, PubMed, PubMed]; Keratins and the keratin-binding protein Albatross are important for epithelial cell polarization., [RefSeq, PubMed]; These results suggest that rs1135889 in FBF1 is not associated with leukoaraiosis (LA) risk in the Chinese population. However, the association of rs1135889 (FBF1) with LA before Bonferroni correction and Sidak correction is worth highlighting., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MEM5;Q96IF6;Q96JG4;Q96MA8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005814 centriole;GO:0036064 ciliary basal body",
        "go_biological_process": "GO:0043297 apical junction assembly;GO:0060271 cilium assembly;GO:0090162 establishment of epithelial cell polarity",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q8TES7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NAC3-1",
        "uniprot_id": [
            {
                "id": "I17RC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NAC3",
                "type": "external"
            }
        ],
        "mass": 86240.0,
        "length": 791,
        "protein_name": "Interleukin-17 receptor C",
        "gene_name": "IL17RC",
        "organism": "Human",
        "refseq_name": "interleukin-17 receptor C isoform 4 precursor",
        "refseq_ac": [
            {
                "id": "NP_001190192",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001190192",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL17RC; PRO38901",
        "gene_names_refseq": "CANDF9; IL17-RL; IL17RC; IL17RL",
        "protein_names_uniprotkb": "Interleukin-17 receptor C; IL-17 receptor C; IL-17RC; IL-17RL; IL17Rhom; Interleukin-17 receptor homolog; Interleukin-17 receptor-like protein; ZcytoR14",
        "protein_names_refseq": "IL-17 receptor C; IL-17RL; IL17F receptor; IL17Rhom; interleukin-17 receptor C isoform 4 precursor; interleukin-17 receptor homolog; interleukin-17 receptor-like protein; zcytoR14",
        "tax_id": 9606,
        "disease": "chronic mucocutaneous candidiasis (Disease Ontology:DOID:2058); interstitial lung disease (Disease Ontology:DOID:3082)",
        "pathway": " (hsa:84818);  (R-HSA-448424);  (R-HSA-9705671)",
        "pathway_count": 3,
        "publication_count": 93,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11574464;11706037;12019269;12692549;12759408;12975309;14504135;15208624;15340161;16397230;16688746;16785495;17911633;18684971;21993848;21993849;22941947;23834281;24120361;25645385;25918342;28827714;29557506;31844290;31850239;32157095;32187518;32353859;32428392;32589897;32726803;32728199;32938616;32953130;32979938;32983136;33024073;33060197;33097660;33110251;33349665;33360543;33372174;33372854;33396605;33440148;33479219;33495715;33514628;33567255;33592498;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33963333;33968037;33989516;33990585;34021074;34054808;34084167;34087483;34110168;34166398;34171305;34239064;34290717;34341353;34375313;34400613;34439781;34452305;34471099;34502139;34597346;35051231;35102342;35167487;35318648;35643212;36010968;36125689;36215666;36701075;37051252;8777726",
        "class_list": "",
        "function": "Associations of IL-17 and IL-17 receptor polymorphisms with Behcet's disease in Denizli Province of Turkey., [RefSeq, PubMed]; Does not bind IL17A or IL17F., [UniProtKB, PubMed]; IL-17 Receptor C Signaling Controls CD4(+) TH17 Immune Responses and Tissue Injury in Immune-Mediated Kidney Diseases., [RefSeq, PubMed]; IL-17A promotes Helicobacter pylori-induced gastric carcinogenesis via interactions with IL-17RC., [RefSeq, PubMed]; IL-17RL exists as multiple isoforms due to extensive alternative splicing. Changes in RNA IL-17RL splicing occur in advanced cancers., [RefSeq, PubMed]; Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity (By similarity). Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RA (PubMed:16785495). Receptor for the heterodimer formed by IL17A and IL17B as part of a heterodimeric complex with IL17RA (PubMed:18684971). Has also been shown to be the cognate receptor for IL17F and to bind IL17A with high affinity without the need for IL17RA (PubMed:17911633). Upon binding of IL17F homodimer triggers downstream activation of TRAF6 and NF-kappa-B signaling pathway (PubMed:16785495, PubMed:32187518). Induces transcriptional activation of IL33, a potent cytokine that stimulates group 2 innate lymphoid cells and adaptive T-helper 2 cells involved in pulmonary allergic response to fungi (By similarity). Promotes sympathetic innervation of peripheral organs by coordinating the communication between gamma-delta T cells and parenchymal cells. Stimulates sympathetic innervation of thermogenic adipose tissue by driving TGFB1 expression (By similarity). Binding of IL17A-IL17F to IL17RA-IL17RC heterodimeric receptor complex triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter through SEFIR domains. This leads to downstream TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:17911633, PubMed:18684971). Primarily induces neutrophil activation and recruitment at infection and inflammatory sites (By similarity). Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Receptor for both IL17A and IL17F., [UniProtKB, PubMed]; This gene encodes a single-pass type I membrane protein that shares similarity with the interleukin-17 receptor (IL-17RA). Unlike IL-17RA, which is predominantly expressed in hemopoietic cells, and binds with high affinity to only IL-17A, this protein is expressed in nonhemopoietic tissues, and binds both IL-17A and IL-17F with similar affinities. The proinflammatory cytokines, IL-17A and IL-17F, have been implicated in the progression of inflammatory and autoimmune diseases. Multiple alternatively spliced transcript variants encoding different isoforms have been detected for this gene, and it has been proposed that soluble, secreted proteins lacking transmembrane and intracellular domains may function as extracellular antagonists to cytokine signaling. [provided by RefSeq, Feb 2011]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8BWC1;A8BWC9;A8BWD5;E9PHG1;E9PHJ6;Q6UVY3;Q6UWD4;Q8NFS1;Q9BR97",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0015026 coreceptor activity;GO:0030368 interleukin-17 receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0032755 positive regulation of interleukin-6 production;GO:0071621 granulocyte chemotaxis;GO:0070534 protein K63-linked ubiquitination;GO:0050832 defense response to fungus",
        "synthesized_glycan_count": 0,
        "hit_score": 10.1,
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    },
    {
        "uniprot_canonical_ac": "Q8N8A8-1",
        "uniprot_id": [
            {
                "id": "F169B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N8A8",
                "type": "external"
            }
        ],
        "mass": 21411.0,
        "length": 192,
        "protein_name": "Protein FAM169BP",
        "gene_name": "FAM169BP",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "FAM169BP; FAM169B; KIAA0888L",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Protein FAM169BP; FAM169BP pseudogene",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MDL8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
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        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "Q8N8A8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q00613-1",
        "uniprot_id": [
            {
                "id": "HSF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q00613",
                "type": "external"
            }
        ],
        "mass": 57260.0,
        "length": 529,
        "protein_name": "Heat shock factor protein 1",
        "gene_name": "HSF1",
        "organism": "Human",
        "refseq_name": "heat shock factor protein 1",
        "refseq_ac": [
            {
                "id": "NP_005517",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005517",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HSF1; HSTF1",
        "gene_names_refseq": "HSF1; HSTF1",
        "protein_names_uniprotkb": "Heat shock factor protein 1; HSF 1; HSTF 1; Heat shock transcription factor 1",
        "protein_names_refseq": "heat shock factor protein 1",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); cryptorchidism (Disease Ontology:DOID:11383); Huntington's disease (Disease Ontology:DOID:12858); neurodegenerative disease (Disease Ontology:DOID:1289); Parkinson's disease (Disease Ontology:DOID:14330); transient cerebral ischemia (Disease Ontology:DOID:224); congestive heart failure (Disease Ontology:DOID:6000); muscular atrophy (Disease Ontology:DOID:767)",
        "pathway": " (hsa:3297);  (R-HSA-3371453);  (R-HSA-3371511);  (R-HSA-3371568);  (R-HSA-3371571);  (R-HSA-9646399);  (R-HSA-9841251)",
        "pathway_count": 7,
        "publication_count": 226,
        "publication_id_list": "10.1101/2023.09.13.557529;10089880;10359787;10413683;10491388;10747973;10954706;11005381;11139588;11162511;11237011;11447121;11514557;11583998;11747420;12024216;12646186;12659875;12665592;12853476;12917326;12974469;14675537;14707147;15016915;15270074;15364926;15661742;15702990;15760475;15802566;1586970;1607379;16278218;1628823;16371476;16554823;17081983;17216044;17322306;17467953;1754405;17785525;17846173;17897941;18212344;18220336;18235501;18235502;18451878;18452278;18550409;18669648;1871105;1871106;18767875;18794143;19229036;19413330;19651622;19664994;19690332;1986252;19910575;19914676;19934326;19936221;19945465;20068231;20166139;20926391;21085490;21597468;22216146;22465953;22496356;22541429;22735644;22768106;22940245;23186163;23349863;23481700;23515720;23665396;24126052;24136149;24200693;24275569;24312621;24412756;24469056;24516381;24581496;24589236;24714562;24715725;24763051;24954509;25087952;25199534;25406061;25425574;25576301;25728673;25811962;25816751;25963659;26010766;26018731;26159920;26359349;26496226;26517842;26727489;26728094;26754925;26768311;26785146;26992070;27043084;27105490;27189267;27354066;27426517;27600516;27639166;27791982;27846572;27997575;28228285;28381880;28383811;28415561;28542269;28618124;28832583;28834231;28904123;29059166;29088759;29242379;29247221;29296831;29316077;29348836;29493099;29606348;29799521;30038221;30138434;30315122;30379171;30429286;30779550;31054961;31109102;31154438;31217245;31409638;31614463;31844290;31848261;31998317;32157095;32161166;32302062;32357974;32387766;32448393;32457290;32488085;32502341;32938616;32959058;32983136;33141586;33298915;33407730;33493517;33592498;33717175;33968037;33981976;34019948;34211107;34239690;34439354;34509645;34561969;34723967;35051231;35080342;35318648;35580925;35959699;36010968;36241641;36284347;38688031;39049197;39122169;39243335;7585962;7623826;7760831;7935376;7935471;8065924;8455624;8721986;8940068;8946918;9121459;9222587;9222609;9305631;9341107;9499401;9535852;9649501;9660838;9727490;9864362;9873016;9920933",
        "class_list": "",
        "function": "(Microbial infection) Plays a role in latent human immunodeficiency virus (HIV-1) transcriptional reactivation. Binds to the HIV-1 long terminal repeat promoter (LTR) to reactivate viral transcription by recruiting cellular transcriptional elongation factors, such as CDK9, CCNT1 and EP300., [UniProtKB, PubMed]; Bag-1-mediated HSF1 phosphorylation regulates expression of heat shock proteins in breast cancer cells., [RefSeq, PubMed]; Functions as a stress-inducible and DNA-binding transcription factor that plays a central role in the transcriptional activation of the heat shock response (HSR), leading to the expression of a large class of molecular chaperones, heat shock proteins (HSPs), that protect cells from cellular insult damage (PubMed:11447121, PubMed:12659875, PubMed:12917326, PubMed:15016915, PubMed:18451878, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7760831, PubMed:8940068, PubMed:8946918, PubMed:9121459, PubMed:9341107, PubMed:9499401, PubMed:9535852, PubMed:9727490). In unstressed cells, is present in a HSP90-containing multichaperone complex that maintains it in a non-DNA-binding inactivated monomeric form (PubMed:11583998, PubMed:16278218, PubMed:9727490). Upon exposure to heat and other stress stimuli, undergoes homotrimerization and activates HSP gene transcription through binding to site-specific heat shock elements (HSEs) present in the promoter regions of HSP genes (PubMed:10359787, PubMed:11583998, PubMed:12659875, PubMed:16278218, PubMed:1871105, PubMed:1986252, PubMed:25963659, PubMed:26754925, PubMed:7623826, PubMed:7935471, PubMed:8455624, PubMed:8940068, PubMed:9499401, PubMed:9727490). Upon heat shock stress, forms a chromatin-associated complex with TTC5/STRAP and p300/EP300 to stimulate HSR transcription, therefore increasing cell survival (PubMed:18451878). Activation is reversible, and during the attenuation and recovery phase period of the HSR, returns to its unactivated form (PubMed:11583998, PubMed:16278218). Binds to inverted 5'-NGAAN-3' pentamer DNA sequences (PubMed:1986252, PubMed:26727489). Binds to chromatin at heat shock gene promoters (PubMed:25963659). Activates transcription of transcription factor FOXR1 which in turn activates transcription of the heat shock chaperones HSPA1A and HSPA6 and the antioxidant NADPH-dependent reductase DHRS2 (PubMed:34723967). Also serves several other functions independently of its transcriptional activity. Involved in the repression of Ras-induced transcriptional activation of the c-fos gene in heat-stressed cells (PubMed:9341107). Positively regulates pre-mRNA 3'-end processing and polyadenylation of HSP70 mRNA upon heat-stressed cells in a symplekin (SYMPK)-dependent manner (PubMed:14707147). Plays a role in nuclear export of stress-induced HSP70 mRNA (PubMed:17897941). Plays a role in the regulation of mitotic progression (PubMed:18794143). Also plays a role as a negative regulator of non-homologous end joining (NHEJ) repair activity in a DNA damage-dependent manner (PubMed:26359349). Involved in stress-induced cancer cell proliferation in a IER5-dependent manner (PubMed:26754925)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Human coronaviruses activate and hijack the host transcription factor HSF1 to enhance viral replication. Publication Status: Online-Only, [RefSeq, PubMed]; Intermolecular Interactions between Cysteine and Aromatic Amino Acids with a Phenyl Moiety in the DNA-Binding Domain of Heat Shock Factor 1 Regulate Thermal Stress-Induced Trimerization., [RefSeq, PubMed]; Protein Misfolding Releases Human HSF1 from HSP70 Latency Control., [RefSeq, PubMed]; The product of this gene is a transcription factor that is rapidly induced after temperature stress and binds heat shock promoter elements (HSE). This protein plays a role in the regulation of lifespan. Expression of this gene is repressed by phosphorylation, which promotes binding by heat shock protein 90. [provided by RefSeq, Jul 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 35,
        "reported_mutagensis": 70,
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        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 8,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K4L0;A8MW26;Q53XT4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0046982 protein heterodimerization activity",
        "go_cellular_component": "GO:0097165 nuclear stress granule;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006397 mRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 23.3,
        "record_id": "Q00613-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UXL0-1",
        "uniprot_id": [
            {
                "id": "I20RB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UXL0",
                "type": "external"
            }
        ],
        "mass": 35076.0,
        "length": 311,
        "protein_name": "Interleukin-20 receptor subunit beta",
        "gene_name": "IL20RB",
        "organism": "Human",
        "refseq_name": "interleukin-20 receptor subunit beta precursor",
        "refseq_ac": [
            {
                "id": "NP_653318",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653318",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL20RB; DIRS1; PRO1114",
        "gene_names_refseq": "DIRS1; FNDC6; IL-20R-beta; IL-20R2; IL-20RB; IL20RB",
        "protein_names_uniprotkb": "Interleukin-20 receptor subunit beta; FNDC6; Fibronectin type III domain containing 6; IL-20 receptor subunit beta; IL-20R-beta; IL-20R2; IL-20RB",
        "protein_names_refseq": "IL-20 receptor subunit beta; fibronectin type III domain containing 6; interleukin 20 receptor beta subunit; interleukin-20 receptor II; interleukin-20 receptor subunit beta precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:53833);  (R-HSA-5684996);  (R-HSA-8854691)",
        "pathway_count": 3,
        "publication_count": 46,
        "publication_id_list": "10.1101/2023.09.13.557529;10875937;11163236;11196675;11237011;11390453;11390454;11481447;11564763;11706020;12087100;12351624;12469119;12975309;14580208;14764663;15120653;15166220;15178681;15340161;15919823;1662392;16750817;16982608;17878297;18599299;18669613;18830264;18941194;19457860;19535621;20462497;20671117;20966397;21098725;22802649;22962576;24715725;25004819;27133025;28458652;31611695;35883015;7512451;7543512;8830676",
        "class_list": "",
        "function": "Forms stable complex with interleukin-19 and interleukin-20 [IL-20R1][IL-20R2], [RefSeq, PubMed]; IL20RB and IL20RA (MIM 605620) form a heterodimeric receptor for interleukin-20 (IL20; MIM 605619) (Blumberg et al., 2001 [PubMed 11163236]).[supplied by OMIM, Feb 2009]., [RefSeq]; Interleukin 20 receptor subunit beta (IL20RB) predicts poor prognosis and regulates immune cell infiltration in clear cell renal cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL22RA1/IL20RB dimer is a receptor for IL20 and IL24., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 1,
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        "reported_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
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        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 9641,
        "biomarker_type": "",
        "glycan_count": 1,
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        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DL40;Q6P438;Q8IYY5;Q8TAJ7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004896 cytokine receptor activity;GO:0042015 interleukin-20 binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0032736 positive regulation of interleukin-13 production;GO:0042127 regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0032689 negative regulation of type II interferon production",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q6UXL0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NPG3-1",
        "uniprot_id": [
            {
                "id": "UBN1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NPG3",
                "type": "external"
            }
        ],
        "mass": 121520.0,
        "length": 1134,
        "protein_name": "Ubinuclein-1",
        "gene_name": "UBN1",
        "organism": "Human",
        "refseq_name": "ubinuclein-1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001072982",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072982",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UBN1",
        "gene_names_refseq": "UBN1; VT4; VT",
        "protein_names_uniprotkb": "Ubinuclein-1; HIRA-binding protein; Protein VT4; Ubiquitously expressed nuclear protein",
        "protein_names_refseq": "HIRA-binding protein; ubinuclein-1 isoform a; ubiquitously expressed nuclear protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29855);  (R-HSA-2559584)",
        "pathway_count": 2,
        "publication_count": 99,
        "publication_id_list": "10725330;11237011;14718166;15621527;15655109;16901784;17081983;17158953;17242198;17242207;18452278;18491316;18823282;19029251;19608861;19651622;19690332;20068231;21084479;21406692;21807893;23186163;23481700;23964094;24275569;24715725;25576301;25645385;26154972;26992070;27217568;27600516;27846572;27920218;28063628;28218747;28314751;28514659;28832583;28834231;28904123;29237092;29242379;29351928;29393594;29437277;29557506;29632046;29786170;30059200;30082790;30379171;30429286;31040182;31492838;31844290;32157095;32265295;32350084;32357974;32502341;32574038;32897882;32938616;32938750;32983136;33141586;33214551;33298915;33392160;33592498;33717175;33912179;33968037;33981976;34019948;34087483;34171305;34185709;34561969;34846842;35051231;35132862;35254053;35289036;35513511;35580925;36010968;36284347;37541260;37938771;37949972;38253038;38665916;39302247;39531497;39534244;40307207;40596516",
        "class_list": "",
        "function": "Activation-induced cytidine deaminase an antibody diversification enzyme interacts with chromatin modifier UBN1 in B-cells. Publication Status: Online-Only, [RefSeq, PubMed]; Acts as a novel regulator of senescence. Involved in the formation of senescence-associated heterochromatin foci (SAHF), which represses expression of proliferation-promoting genes. Binds to proliferation-promoting genes. May be required for replication-independent chromatin assembly., [UniProtKB, PubMed, PubMed]; Analyses have revealed that in most cells ubinuclein occurred in the nucleoplasm, but in cells forming tight junctions it is recruited to the plaque structure of the zonula occludens., [RefSeq, PubMed]; Analysis of the trimeric HIRA, UBN1 and CABIN1 H3.3 histone chaperone complex Publication Status: Online-Only, [RefSeq, PubMed]; By a chromatin immunoprecipitation (ChIP) assay, the authors show that Ubn-1 blocks EB1-human herpesvirus 4 DNA interaction., [RefSeq, PubMed]; Cellular senescence is a hallmark of tumor suppression and tissue aging. Senescent cells contain domains of heterochromatin, called senescence-associated heterochromatin foci (SAHF), that repress proliferation-promoting genes. The protein encoded by this gene binds to proliferation-promoting genes and is required for SAHF formation, enhancing methylation of histone H3. [provided by RefSeq, Oct 2016]., [RefSeq]; Data show that, like HIRA, UBN1, and ASF1a, CABIN1 is involved in heterochromatinization of the genome of senescent human cells., [RefSeq, PubMed]; Hpc2-related domain of UBN1, UBN2, and Hpc2p is an evolutionarily conserved HIRA/Hir-binding domain, which directly interacts with the N-terminal WD repeats of HIRA/Hir., [RefSeq, PubMed]; UBN1 may be capable of binding two H3.3/H4 molecules to facilitate (H3.3/H4)2 tetramer formation in a pathway to nucleosome deposition that may also involve UBN1-mediated DNA binding by the HIRA complex., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 27,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 27,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 27,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 15,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 50,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 27,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z6D3;D3DUE8;Q13079;Q9P1P7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005923 bicellular tight junction;GO:0016604 nuclear body;GO:0016605 PML body",
        "go_biological_process": "GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:1902275 regulation of chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 12.9,
        "record_id": "Q9NPG3-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95760-1",
        "uniprot_id": [
            {
                "id": "IL33_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95760",
                "type": "external"
            }
        ],
        "mass": 30759.0,
        "length": 270,
        "protein_name": "Interleukin-33",
        "gene_name": "IL33",
        "organism": "Human",
        "refseq_name": "interleukin-33 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001186569",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186569",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL33; C9orf26; IL1F11; NFHEV",
        "gene_names_refseq": "C9orf26; DVS27; IL1F11; IL33; NF-HEV; NFEHEV",
        "protein_names_uniprotkb": "Interleukin-33; IL-1F11; IL-33; Interleukin-1 family member 11; NF-HEV; Nuclear factor from high endothelial venules",
        "protein_names_refseq": "DVS27-related protein; interleukin-1 family member 11; interleukin-33 isoform b; nuclear factor for high endothelial venules; nuclear factor from high endothelial venules",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589); obstructive sleep apnea (Disease Ontology:DOID:0050848); tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); colitis (Disease Ontology:DOID:0060180); aortic atherosclerosis (Disease Ontology:DOID:10230); common cold (Disease Ontology:DOID:10459); pleural tuberculosis (Disease Ontology:DOID:106); Alzheimer's disease (Disease Ontology:DOID:10652); Hantavirus hemorrhagic fever with renal syndrome (Disease Ontology:DOID:11266); pulmonary edema (Disease Ontology:DOID:11396); paracoccidioidomycosis (Disease Ontology:DOID:12662); gout (Disease Ontology:DOID:13189); clonorchiasis (Disease Ontology:DOID:13767); candidiasis (Disease Ontology:DOID:1508); colon cancer (Disease Ontology:DOID:219); asthma (Disease Ontology:DOID:2841); tuberculosis (Disease Ontology:DOID:399); liver cirrhosis (Disease Ontology:DOID:5082); pulmonary hypertension (Disease Ontology:DOID:6432); peptic ulcer disease (Disease Ontology:DOID:750); herpes simplex (Disease Ontology:DOID:8566); ulcerative colitis (Disease Ontology:DOID:8577); diabetes mellitus (Disease Ontology:DOID:9351); acute myocardial infarction (Disease Ontology:DOID:9408); allergic asthma (Disease Ontology:DOID:9415); irritable bowel syndrome (Disease Ontology:DOID:9778)",
        "pathway": " (hsa:90865);  (R-HSA-1257604);  (R-HSA-5689880);  (R-HSA-6811558);  (R-HSA-9014843)",
        "pathway_count": 5,
        "publication_count": 115,
        "publication_id_list": "10191262;10444327;10566975;10982817;11147812;11566882;11803464;11923872;12167717;12767043;12819012;12917689;12917691;1325671;14661020;15053880;15718470;15916963;16214042;16286016;16456541;16901786;16964248;17185418;17200115;17290220;17443180;17853410;17873522;17980597;17981138;18172164;18467330;18632802;18636086;18787100;18836528;18925875;19015242;19135894;19188362;19363159;19398555;19424180;19439663;19465481;19559631;19576174;19596270;19805105;19836339;19838211;19841166;19874889;19910467;20096447;20228808;20338997;20368735;20501646;21239494;21362556;21454686;21571647;21596315;21659512;21734074;21827948;21849505;21962518;22029577;22085928;22128162;22215666;22216260;22307629;23159851;23395819;23486064;23824326;23825189;23980170;24056413;24260525;24493797;24896179;25197364;25305019;25578727;27862975;28715472;29045903;29557506;30429286;31154438;31530632;31844290;31848261;32157095;32272059;34185709;35051231;35580925;35794369;38617533;38662248;38858740;38923705;38942797;7578059;7637810;7744773;8645157;9736715;9895304",
        "class_list": "",
        "function": "BAG6 restricts pancreatic cancer progression by suppressing the release of IL33-presenting extracellular vesicles and the activation of mast cells., [RefSeq, PubMed]; Comprehensively analysis of IL33 in hepatocellular carcinoma prognosis, immune microenvironment and biological role., [RefSeq, PubMed]; Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells (PubMed:16286016, PubMed:19841166). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines (PubMed:17853410, PubMed:18836528). Also involved in activation of mast cells, basophils, eosinophils and natural killer cells (PubMed:17853410, PubMed:18836528). Acts as an enhancer of polarization of alternatively activated macrophages (PubMed:19841166). Acts as a chemoattractant for Th2 cells, and may function as an 'alarmin', that amplifies immune responses during tissue injury (PubMed:17853410, PubMed:18836528). Induces rapid UCP2-dependent mitochondrial rewiring that attenuates the generation of reactive oxygen species and preserves the integrity of Krebs cycle required for persistent production of itaconate and subsequent GATA3-dependent differentiation of inflammation-resolving alternatively activated macrophages (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; IL-33 Accelerates Chronic Atrophic Gastritis through AMPK-ULK1 Axis Mediated Autolysosomal Degradation of GKN1. Publication Status: Online-Only, [RefSeq, PubMed]; In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets (PubMed:21734074). This form is rapidely lost upon angiogenic or pro-inflammatory activation (PubMed:18787100)., [UniProtKB, PubMed, PubMed]; Interleukin 33 supports squamous cell carcinoma growth via a dual effect on tumour proliferation, migration and invasion, and T cell activation. Publication Status: Online-Only, [RefSeq, PubMed]; LTR-IL-33 expression is required for optimal CRC cell line growth Publication Status: Online-Only, [RefSeq, PubMed]; Results suggest that NF-HEV may be one of the key nuclear factors that controls the specialized phenotype of the lymphatic venule endothelium., [RefSeq, PubMed]; The IL-33-ST2 axis plays a vital role in endometriosis via promoting epithelial-mesenchymal transition by phosphorylating beta-catenin. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a cytokine that binds to the IL1RL1/ST2 receptor. The encoded protein is involved in the maturation of Th2 cells and the activation of mast cells, basophils, eosinophils and natural killer cells. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 26,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8L1;B4DJ35;B4E1Q9;D3DRI5;E7EAX4;Q2YEJ5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0002112 interleukin-33 receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0043032 positive regulation of macrophage activation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "O95760-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P35225-1",
        "uniprot_id": [
            {
                "id": "IL13_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P35225",
                "type": "external"
            }
        ],
        "mass": 15788.0,
        "length": 146,
        "protein_name": "Interleukin-13",
        "gene_name": "IL13",
        "organism": "Human",
        "refseq_name": "interleukin-13 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_002179",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002179",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL13; NC30",
        "gene_names_refseq": "IL-13; IL13; P600",
        "protein_names_uniprotkb": "Interleukin-13; IL-13",
        "protein_names_refseq": "interleukin-13 isoform 1 precursor",
        "tax_id": 9606,
        "disease": "sinusitis (Disease Ontology:DOID:0050127); respiratory allergy (Disease Ontology:DOID:0060496); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); COVID-19 (Disease Ontology:DOID:0080600); lipoid nephrosis (Disease Ontology:DOID:10966); prostatic hypertrophy (Disease Ontology:DOID:11132); allergic conjunctivitis (Disease Ontology:DOID:11204); pulmonary edema (Disease Ontology:DOID:11396); onchocerciasis (Disease Ontology:DOID:11678); allergic disease (Disease Ontology:DOID:1205); vitiligo (Disease Ontology:DOID:12306); alcoholic hepatitis (Disease Ontology:DOID:12351); Graves' disease (Disease Ontology:DOID:12361); Sjogren's syndrome (Disease Ontology:DOID:12894); uveitis (Disease Ontology:DOID:13141); Mycoplasma pneumoniae pneumonia (Disease Ontology:DOID:13276); peptic esophagitis (Disease Ontology:DOID:13976); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); cystic fibrosis (Disease Ontology:DOID:1485); diffuse scleroderma (Disease Ontology:DOID:1580); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); multiple sclerosis (Disease Ontology:DOID:2377); dermatitis (Disease Ontology:DOID:2723); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); pulmonary tuberculosis (Disease Ontology:DOID:2957); invasive ductal carcinoma (Disease Ontology:DOID:3008); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); purpura (Disease Ontology:DOID:3326); mastocytosis (Disease Ontology:DOID:350); middle cerebral artery infarction (Disease Ontology:DOID:3525); pulmonary fibrosis (Disease Ontology:DOID:3770); ovarian carcinoma (Disease Ontology:DOID:4001); systemic scleroderma (Disease Ontology:DOID:418); milk allergy (Disease Ontology:DOID:4376); egg allergy (Disease Ontology:DOID:4377); peanut allergy (Disease Ontology:DOID:4378); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); pancreatitis (Disease Ontology:DOID:4989); pneumonia (Disease Ontology:DOID:552); pulmonary hypertension (Disease Ontology:DOID:6432); rheumatoid arthritis (Disease Ontology:DOID:7148); extrinsic allergic alveolitis (Disease Ontology:DOID:841); localized scleroderma (Disease Ontology:DOID:8472); lung disease (Disease Ontology:DOID:850); psoriasis (Disease Ontology:DOID:8893); psoriatic arthritis (Disease Ontology:DOID:9008); systemic lupus erythematosus (Disease Ontology:DOID:9074)",
        "pathway": " (hsa:3596);  (R-HSA-6785807);  (R-HSA-9012546);  (R-HSA-9976102)",
        "pathway_count": 4,
        "publication_count": 113,
        "publication_id_list": "10023775;10023777;10219247;10369418;10510379;10586089;10699178;10867011;11058569;11084045;11104795;11120780;11278437;11278729;11356008;11404481;11419948;11463377;11588017;11960372;12223527;12242343;12600988;12832402;12928861;1408833;14634100;14712222;15116091;15261459;15584925;15805299;15869882;15950906;16007214;16048438;16107692;16205632;16236134;16397018;16451196;16510571;16540365;16606674;17427945;17458857;17572495;18243101;18353781;18447642;18644974;19124156;19185846;19397496;20223216;20493732;21102457;21252155;21622864;21689689;21730069;21937440;21994466;22046235;22205702;22383755;22693070;22851691;23086340;23124025;23172665;23455323;23555662;23967200;24097101;24220297;24743777;25234944;29242379;38885591;38985531;39088580;39242402;39380276;7510216;7512451;7529288;7721105;7795521;7796300;7898939;7903680;7907877;8085155;8096327;8097324;8602263;8605348;8621622;8639787;8663118;8668165;8759755;8797861;8816495;9013879;9325300;9651359;9723655;9736340;9792649;9822675;9874564",
        "class_list": "",
        "function": "A call for clinical trials in glioblastoma multiforme for interleukin 4, interleukin 6, interleukin 13 and CD40. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Association of CTACK, IL-2, and IL-13 with increased risk of lung cancer: A Mendelian randomization study., [RefSeq, PubMed]; Association of IL-13 rs20541, FOXP3 rs3761548 genes polymorphisms and serum level of IL-13 with allergic asthma in Egyptian patients., [RefSeq, PubMed]; Association of IL13 polymorphisms with susceptibility to myocardial infarction: A case-control study in Chinese population. Publication Status: Online-Only, [RefSeq, PubMed]; Cytokine that plays important roles in allergic inflammation and immune response to parasite infection (PubMed:8096327, PubMed:8097324). Synergizes with IL2 in regulating interferon-gamma synthesis (PubMed:8096327). Stimulates B-cell proliferation, and activation of eosinophils, basophils, and mast cells (PubMed:7903680, PubMed:8759755). Plays an important role in controlling IL33 activity by modulating the production of transmembrane and soluble forms of interleukin-1 receptor-like 1/IL1RL1 (By similarity). Displays the capacity to antagonize Th1-driven proinflammatory immune response and downregulates synthesis of many proinflammatory cytokines including IL1, IL6, IL10, IL12 and TNF through a mechanism that partially involves suppression of NF-kappa-B (By similarity). Also functions on nonhematopoietic cells, including endothelial cells where it induces vascular cell adhesion protein 1/VCAM1, which is important in the recruitment of eosinophils (PubMed:8639787). Exerts its biological effects through its receptors which comprises the IL4R chain and the IL13RA1 chain, to activate JAK1 and TYK2, leading to the activation of STAT6 (PubMed:9013879). Aside from IL13RA1, another receptor IL13RA2 acts as a high affinity decoy for IL13 and mediates internalization and depletion of extracellular IL13 (PubMed:21622864). Induces inflammatory response in esophageal epithelium which results in a dysregulation of desmosome intercellular adhesion junctions, via down-regulation of DSG1 (PubMed:24220297)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Seasonal distribution and correlation between IL-10 and IL-13 gene polymorphism and their expression in scabies-infected patients. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an immunoregulatory cytokine produced primarily by activated Th2 cells. This cytokine is involved in several stages of B-cell maturation and differentiation. It up-regulates CD23 and MHC class II expression, and promotes IgE isotype switching of B cells. This cytokine down-regulates macrophage activity, thereby inhibits the production of pro-inflammatory cytokines and chemokines. This cytokine is found to be critical to the pathogenesis of allergen-induced asthma but operates through mechanisms independent of IgE and eosinophils. This gene, IL3, IL5, IL4, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL4. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 51,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43644;Q4VB52;Q9UDC7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005144 interleukin-13 receptor binding;GO:0005125 cytokine activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0071635 negative regulation of transforming growth factor beta production;GO:1901247 negative regulation of lung ciliated cell differentiation;GO:1901251 positive regulation of lung goblet cell differentiation;GO:2000231 positive regulation of pancreatic stellate cell proliferation;GO:0043032 positive regulation of macrophage activation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.4,
        "record_id": "P35225-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H1X1-1",
        "uniprot_id": [
            {
                "id": "RSPH9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H1X1",
                "type": "external"
            }
        ],
        "mass": 31292.0,
        "length": 276,
        "protein_name": "Radial spoke head protein 9 homolog",
        "gene_name": "RSPH9",
        "organism": "Human",
        "refseq_name": "radial spoke head protein 9 homolog isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001180270",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180270",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RSPH9; C6orf206; MRPS18AL1",
        "gene_names_refseq": "C6orf206; CILD12; MRPS18AL1; RSPH9",
        "protein_names_uniprotkb": "Radial spoke head protein 9 homolog",
        "protein_names_refseq": "radial spoke head 9 homolog; radial spoke head protein 9 homolog isoform 2; radial spoke head protein 9 homolog",
        "tax_id": 9606,
        "disease": "primary ciliary dyskinesia 12 (Disease Ontology:DOID:0110601)",
        "pathway": " (hsa:221421)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "19200523;20070851;22448264;30379171;35051231",
        "class_list": "",
        "function": "Functions as part of axonemal radial spoke complexes that play an important part in the motility of sperm and cilia (PubMed:19200523). Essential for both the radial spoke head assembly and the central pair microtubule stability in ependymal motile cilia (By similarity). Required for motility of olfactory and neural cilia and for the structural integrity of ciliary axonemes in both 9+0 and 9+2 motile cilia (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Mutations in RSPH9 leads to ultrastructural cilia defects and ciliary dyskinesia., [RefSeq, PubMed]; Study focused on an extended 5 generation Bedouin family, analysed mutation segregation, and calculated the age of the mutated allele in 2 families based on haplotypes and haplotype+microsatellite in an attempt to define the source of the mutation., [RefSeq, PubMed]; This gene encodes a protein thought to be a component of the radial spoke head in motile cilia and flagella. Mutations in this gene are associated with primary ciliary dyskinesia 12. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5T4;Q96NH9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005929 cilium;GO:0031514 motile cilium;GO:0036126 sperm flagellum;GO:0005930 axoneme;GO:0060091 kinocilium",
        "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:1904158 axonemal central apparatus assembly;GO:0030317 flagellated sperm motility;GO:0044458 motile cilium assembly;GO:0003341 cilium movement",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q9H1X1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95714-1",
        "uniprot_id": [
            {
                "id": "HERC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95714",
                "type": "external"
            }
        ],
        "mass": 527228.0,
        "length": 4834,
        "protein_name": "E3 ubiquitin-protein ligase HERC2",
        "gene_name": "HERC2",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase HERC2",
        "refseq_ac": [
            {
                "id": "NP_004658",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004658",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HERC2",
        "gene_names_refseq": "D15F37S1; HERC2; MRT38; SHEP1; jdf2; p528",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HERC2; 2.3.2.26; HECT domain and RCC1-like domain-containing protein 2; HECT-type E3 ubiquitin transferase HERC2",
        "protein_names_refseq": "E3 ubiquitin-protein ligase HERC2; HECT-type E3 ubiquitin transferase HERC2; hect domain and RCC1-like domain-containing protein 2; hect domain and RLD 2; probable E3 ubiquitin-protein ligase HERC2",
        "tax_id": 9606,
        "disease": "autosomal recessive intellectual developmental disorder 38 (Disease Ontology:DOID:0081203); pigmentation disease (Disease Ontology:DOID:10123); obsolete skin/hair/eye pigmentation, variation in, 1 (MONDO:MONDO:0044255)",
        "pathway": " (hsa:8924);  (R-HSA-3108214);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-69473);  (R-HSA-983168)",
        "pathway_count": 7,
        "publication_count": 351,
        "publication_id_list": "10.1101/2023.09.13.557529;10550055;10572166;10574707;10720573;10724175;10757784;10766245;10802669;10859164;10866324;10959836;10973490;11025670;11062501;11080452;11114888;11139606;11237011;11301010;11350924;11376695;11390408;11390642;11493912;11571274;11573085;11604075;11702069;11792325;11889051;11893489;11927591;11934988;11955432;12023295;12077346;12152085;12186630;12231622;12364621;12447390;12485996;12509254;12545175;12578958;12607003;12607005;12646216;12697768;12773400;12791985;12792649;12832489;12890688;12897153;12947387;14560035;14561766;14576433;14734113;15064416;15175327;15177042;15189136;15190204;15201865;15224091;15224092;15279782;15355988;15451442;15468306;15571818;15574327;15608651;15707391;15723659;15823533;15829507;15940266;15959518;16030353;16061182;16093244;16148040;16150728;16153896;16327781;16360315;16377563;16427009;16439204;16439205;16478998;16530042;16595681;16600297;16608850;16626738;16651405;16688858;16810316;16849449;16874298;16885023;16914548;16954532;17081983;17290226;17322306;17470781;17525332;17525340;17553757;17575048;17693435;17848578;17928296;17965729;18001824;18001825;18006705;18046455;18077395;18171670;18172690;18252221;18252222;18397950;18443292;18491316;18625722;18644861;18662542;18669648;18691969;18691976;18708356;18805091;18923075;18971343;19001859;19028597;19092802;19117993;19176521;19203578;19203579;19234442;19261749;19287951;19351884;19352404;19357644;19413330;19419957;19452197;19489725;19505854;19596686;19622798;19651622;19690332;19706679;19779455;19782031;19851334;19874575;19940261;19956565;20016594;20016603;20023648;20068231;20154705;20190268;20233725;20304803;20351172;20457063;20705237;21052091;21098080;21147198;21240188;21263215;21282113;21284855;21293379;21325134;21335604;21406692;21550342;21659603;21680713;21777809;22021381;22024395;22179609;22231403;22234877;22261722;22373579;22508508;22529269;22589545;2261476;22635276;22661229;22661230;22751501;22792074;22908299;22977173;22980979;23065719;23186163;23306437;23333306;23345434;23468639;23481700;23505375;23727112;23750026;23871147;24027577;24236237;24366607;24667604;24714562;24715725;24778179;24782567;25113031;25114211;25122754;25218447;25418920;25512557;25558984;25576301;25645385;25659039;25818648;25841101;25892735;26154972;26375851;26692333;26728094;26811146;26992070;27397612;27543614;27846572;27862975;27920218;28218747;28228285;28446606;28467828;28514659;28832583;28834231;28855257;28904123;29242379;29314611;29351928;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29671580;29741879;29786170;30192525;30315122;30379171;30410026;30429286;30524438;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33392160;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34357683;34405274;34509645;34561969;34932366;35051231;35154160;35318648;35580925;36010968;36172813;36215666;36241641;36284347;36721234;37074924;37217939;37480851;40307207;8422676;8944023;9168116;9259561;9380723;9412458;9430729;9452416;9488723;9512523;9668046;9705271;9756909;9826654;9885291;9949213",
        "class_list": "",
        "function": "E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway. Also modulates iron metabolism by regulating the basal turnover of FBXL5., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; EHD1 promotes CP110 ubiquitination by centriolar satellite delivery of HERC2 to the mother centriole., [RefSeq, PubMed]; HERC2 promotes inflammation-driven cancer stemness and immune evasion in hepatocellular carcinoma by activating STAT3 pathway. Erratum:[J Exp Clin Cancer Res. 2024 Nov 13;43(1):300. doi: 10.1186/s13046-024-03223-4. PMID: 39538344] Publication Status: Online-Only, [RefSeq, PubMed]; Mechanism of orphan subunit recognition during assembly quality control., [RefSeq, PubMed]; This gene belongs to the HERC gene family that encodes a group of unusually large proteins, which contain multiple structural domains. All members have at least 1 copy of an N-terminal region showing homology to the cell cycle regulator RCC1 and a C-terminal HECT (homologous to E6-AP C terminus) domain found in a number of E3 ubiquitin protein ligases. Genetic variations in this gene are associated with skin/hair/eye pigmentation variability. Multiple pseudogenes of this gene are located on chromosomes 15 and 16. [provided by RefSeq, Mar 2012]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 17,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 143,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 3,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86SV7;Q86SV8;Q86SV9;Q86YY3;Q86YY4;Q86YY5;Q86YY6;Q86YY7;Q86YY8;Q86YY9;Q86YZ0;Q86YZ1",
        "ec_number_list": [
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
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            },
            {
                "id": "2.3.2.31",
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                "type": "external"
            },
            {
                "id": "1.14.11.69",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.69",
                "type": "external"
            },
            {
                "id": "1.14.11.66",
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            },
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                "id": "2.3.2.-",
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                "type": "external"
            },
            {
                "id": "2.1.1.357",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.357",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "3.4.19.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.-",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
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            },
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            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
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            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
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            },
            {
                "id": "2.3.1.48",
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                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0061630 ubiquitin protein ligase activity;GO:0032183 SUMO binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006886 intracellular protein transport;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0050821 protein stabilization",
        "synthesized_glycan_count": 0,
        "hit_score": 36.8,
        "record_id": "O95714-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.000100.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9P2D6-1",
        "uniprot_id": [
            {
                "id": "F135A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9P2D6",
                "type": "external"
            }
        ],
        "mass": 169840.0,
        "length": 1515,
        "protein_name": "Protein FAM135A",
        "gene_name": "FAM135A",
        "organism": "Human",
        "refseq_name": "protein FAM135A isoform a",
        "refseq_ac": [
            {
                "id": "NP_001099001",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099001",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM135A; KIAA1411",
        "gene_names_refseq": "FAM135A; KIAA1411",
        "protein_names_uniprotkb": "Protein FAM135A",
        "protein_names_refseq": "protein FAM135A isoform a; protein FAM135A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57579);  (R-HSA-9696273)",
        "pathway_count": 2,
        "publication_count": 69,
        "publication_id_list": "10664463;11230166;11237011;11784792;11940653;12842009;15738000;16192744;18996843;19103606;20811643;23481700;24690281;25576301;25645385;25892735;26154972;26992070;27600516;28228285;28832583;28904123;29242379;29437277;29493099;29557506;30315122;30379171;30429286;30484775;30524438;30620550;31217245;31844290;31871319;32157095;32357974;32387766;32897882;32938616;32938750;32983136;33141586;33298915;33392160;33592498;33633747;33912179;33968037;33981976;34171305;34185709;34211107;34509645;34932366;35051231;35254053;35561310;35580925;36010968;36241641;36284347;36943627;37074911;37541260;38253038;39302247;39531497;9531558",
        "class_list": "",
        "function": "LncRNA MIR17HG Suppresses Breast Cancer Proliferation and Migration as ceRNA to Target FAM135A by Sponging miR-454-3p., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "A2RRQ5;Q3C0H3;Q5JXK0;Q5JXK1;Q68DW0;Q6P081;Q9H0F2;Q9NU48;Q9NUQ5;Q9NXL5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0006629 lipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "Q9P2D6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WU58-1",
        "uniprot_id": [
            {
                "id": "F222B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WU58",
                "type": "external"
            }
        ],
        "mass": 59652.0,
        "length": 562,
        "protein_name": "Protein FAM222B",
        "gene_name": "FAM222B",
        "organism": "Human",
        "refseq_name": "protein FAM222B isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001070966",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070966",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM222B; C17orf63",
        "gene_names_refseq": "C17orf63; FAM222B",
        "protein_names_uniprotkb": "Protein FAM222B",
        "protein_names_refseq": "protein FAM222B isoform 2; protein FAM222B; uncharacterized protein C17orf63",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55731)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "11237011;25576301;25892735;26992070;28228285;28254787;28446606;28657654;28832583;29242379;29769354;30779550;31217245;31492838;31844290;32157095;33968037;33981976;35051231;35580925;36010968;37217939;37340703;38665916",
        "class_list": "",
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        "total_reported_n_glycosites": 0,
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        "secondary_ac_list": "Q9H6F3;Q9NVJ4;Q9NXN6",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q8WU58-1",
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        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001000.001.00000",
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    },
    {
        "uniprot_canonical_ac": "Q86XA9-1",
        "uniprot_id": [
            {
                "id": "HTR5A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86XA9",
                "type": "external"
            }
        ],
        "mass": 222004.0,
        "length": 2040,
        "protein_name": "HEAT repeat-containing protein 5A",
        "gene_name": "HEATR5A",
        "organism": "Human",
        "refseq_name": "HEAT repeat-containing protein 5A",
        "refseq_ac": [
            {
                "id": "NP_056288",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056288",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEATR5A; C14orf125; KIAA1316",
        "gene_names_refseq": "C14orf125; HEATR5A; p200b",
        "protein_names_uniprotkb": "HEAT repeat-containing protein 5A",
        "protein_names_refseq": "HEAT repeat-containing protein 5A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25938)",
        "pathway_count": 1,
        "publication_count": 60,
        "publication_id_list": "11237011;18691976;24715725;25576301;25645385;26375851;26992070;27600516;27846572;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632711;29786170;29789417;30315122;30379171;30484775;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33592498;33912179;33968037;33981976;34087483;34171305;34357683;34509645;35051231;35561310;35580925;36010968;36215666;36241641;36284347;37938771;38240799",
        "class_list": "",
        "function": "Fast-evolving cofactors regulate the role of HEATR5 complexes in intra-Golgi trafficking., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q68DD8;Q6P3S5;Q6P5R9;Q9H8D7;Q9NXB7;Q9P2N0;Q9UFQ3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0030139 endocytic vesicle",
        "go_biological_process": "GO:0006897 endocytosis;GO:0008104 intracellular protein localization;GO:0042147 retrograde transport, endosome to Golgi",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q86XA9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9ULQ1-1",
        "uniprot_id": [
            {
                "id": "TPC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9ULQ1",
                "type": "external"
            }
        ],
        "mass": 94147.0,
        "length": 816,
        "protein_name": "Two pore channel protein 1",
        "gene_name": "TPCN1",
        "organism": "Human",
        "refseq_name": "two pore channel protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001137291",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137291",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TPCN1; KIAA1169; TPC1",
        "gene_names_refseq": "TPC1; TPCN1",
        "protein_names_uniprotkb": "Two pore channel protein 1; Two pore calcium channel protein 1; Voltage-dependent calcium channel protein TPC1",
        "protein_names_refseq": "two pore calcium channel protein 1; two pore channel protein 1 isoform 1; two pore channel protein 1; two-pore channel 1, homolog; voltage-dependent calcium channel protein TPC1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:53373);  (R-HSA-2672351)",
        "pathway_count": 2,
        "publication_count": 147,
        "publication_id_list": "10564087;10642508;10720933;10767424;10830164;10831588;11182090;11237011;11588175;11687798;11734858;11842292;11904445;11956057;12393854;12907679;1379744;14584882;14634667;15010458;15044642;15147738;15318163;15504734;15505377;15916532;15919655;16219661;16813530;16849430;16850186;17381423;17448995;17699613;17881003;18000046;18063579;18310267;18400985;18449189;18508966;18662336;18724360;19153159;19307298;19380724;19387438;19620632;19808995;19953639;20388639;20466723;20525693;20538786;20880839;21040849;21527911;21984732;22002868;22773952;22946059;2298749;23063126;23112050;2321095;23394946;23481700;23616951;24190977;24397554;24715725;24776928;2536303;25576301;25645385;25722412;25892735;26154972;26359375;26375851;26562072;26811146;26992070;27353380;27846572;27920218;28071645;28154142;28218747;28252105;28514659;28790369;28855257;28904123;29129203;29242379;29393594;29557506;30315122;30779550;30860481;31154438;31557916;31844290;31848261;31998317;32157095;32350084;32357974;32387766;32488085;32679067;32897882;32938616;32983136;33141586;33298915;33592498;33912179;33968037;34357683;34362892;34509645;34932366;35051231;35580925;36241641;36284347;37938771;39894887;7588753;7665160;7795595;8041726;8112288;8383669;8533761;8544406;8626462;8809036;9037075;9395096;9571199;9662395;9700209;9719863;9744806",
        "class_list": "",
        "function": "(Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm., [UniProtKB, PubMed]; A cluster of arginine residues in the first domain required for selective voltage-gating of TPC1 map not to the voltage-sensing fourth transmembrane region (S4) but to a cytosolic downstream region (S4-S5 linker)., [RefSeq, PubMed]; Cryo-EM structure of human TPC2 provides insights into the mechanism of PI(3,5)P2-regulated gating of TPC2, which is distinct from that of TPC1 Publication Status: Online-Only, [RefSeq, PubMed]; Data show that human two-pore channel TPC1 is critical for nicotinic acid adenine dinucleotide phosphate action and is likely the long sought after target channel for NAADP., [RefSeq, PubMed]; Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a voltage-gated highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) that senses pH changes and confers electrical excitability to organelles (PubMed:19620632, PubMed:23063126, PubMed:23394946, PubMed:24776928). Localizes to the early and recycling endosomes membranes where it plays a role in the uptake and processing of proteins and regulates organellar membrane excitability, membrane trafficking and pH homeostasis (Probable) (PubMed:23394946). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (Probable). Required for mTOR-dependent nutrient sensing (Probable) (PubMed:23394946)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; TPC1 is involved in the norepinephrine (NE)-stimulated [Ca(2+)]i rise in Smooth muscle cells. Inhibition of TPC1 activity by NED 19 could be the reason for partial inhibition of aortic rings contraction in response to NE. Publication Status: Online-Only, [RefSeq, PubMed]; These data point to a process in which Ca(2+) permeation in human TPC1 has a positive feedback on channel activity while Na(+) acts as a negative regulator. Publication Status: Online-Only, [RefSeq, PubMed]; These findings indicate potential differential regulation of signaling processes by TPC1 and TPC2 in breast cancer cells., [RefSeq, PubMed]; Voltage-gated Ca(2+) and Na+ channels have 4 homologous domains, each containing 6 transmembrane segments, S1 to S6. TPCN1 is similar to these channels, but it has only 2 domains containing S1 to S6 (Ishibashi et al., 2000 [PubMed 10753632]).[supplied by OMIM, Mar 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7E258;Q86XS9;Q8NC20",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0072345 NAADP-sensitive calcium-release channel activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0019905 syntaxin binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding",
        "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane",
        "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0010508 positive regulation of autophagy;GO:0075509 endocytosis involved in viral entry into host cell",
        "synthesized_glycan_count": 0,
        "hit_score": 15.2,
        "record_id": "Q9ULQ1-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9GZU8-1",
        "uniprot_id": [
            {
                "id": "PIP30_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9GZU8",
                "type": "external"
            }
        ],
        "mass": 28912.0,
        "length": 254,
        "protein_name": "PSME3-interacting protein",
        "gene_name": "PSME3IP1",
        "organism": "Human",
        "refseq_name": "PSME3-interacting protein isoform a",
        "refseq_ac": [
            {
                "id": "NP_079222",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079222",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSME3IP1; C16orf94; CDA018; CDA10; FAM192A; NIP30; PIP30",
        "gene_names_refseq": "C16orf94; CDA018; CDA10; FAM192A; NIP30; PIP30; PSME3IP1",
        "protein_names_uniprotkb": "PSME3-interacting protein; NEFA-interacting nuclear protein NIP30; PA28G-interacting protein",
        "protein_names_refseq": "NEFA-interacting nuclear protein NIP30; PA28G interacting protein 30kDa; PA28G-interacting protein; PSME3 interacting protein 30kDa; PSME3-interacting protein isoform a; PSME3-interacting protein; family with sequence similarity 192 member A; protein FAM192A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80011)",
        "pathway_count": 1,
        "publication_count": 50,
        "publication_id_list": "11237011;19608861;20068231;22223895;23186163;23301498;24714562;26992070;28832583;29242379;29393594;29493099;29557506;29934401;30429286;30833945;31154438;31217245;31222486;31844290;31848261;31998317;32161166;32350084;32357974;32387766;32502341;32764536;32897882;32938616;32983136;33298915;33691108;33717175;33912179;33968037;33981976;34019948;34087483;34171305;34509645;34561969;35051231;35251023;35318648;35561310;35580925;36010968;36284347;38556586",
        "class_list": "",
        "function": "Data show that PIP30 deeply affects PA28gamma interactions with cellular proteins, including the 20S proteasome, demonstrating that it is an important regulator of PA28gamma in cells and thus a new player in the control of the multiple functions of the proteasome within the nucleus., [RefSeq, PubMed]; Fat mass and obesity-associated protein (FTO) mediated m[6]A modification of circFAM192A promoted gastric cancer proliferation by suppressing SLC7A5 decay. Publication Status: Online-Only, [RefSeq, PubMed]; Promotes the association of the proteasome activator complex subunit PSME3 with the 20S proteasome and regulates its activity. Inhibits PSME3-mediated degradation of some proteasome substrates, probably by affecting their diffusion rate into the catalytic chamber of the proteasome. Also inhibits the interaction of PSME3 with COIL, inhibits accumulation of PSME3 in Cajal bodies and positively regulates the number of Cajal bodies in the nucleus., [UniProtKB, PubMed]; The REGgamma inhibitor NIP30 increases sensitivity to chemotherapy in p53-deficient tumor cells. Erratum:[Nat Commun. 2020 Sep 23;11(1):4888. doi: 10.1038/s41467-020-18767-0. PMID: 32968062] Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0032091 negative regulation of protein binding;GO:0000398 mRNA splicing, via spliceosome;GO:1901799 negative regulation of proteasomal protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q9GZU8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P50213-1",
        "uniprot_id": [
            {
                "id": "IDH3A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P50213",
                "type": "external"
            }
        ],
        "mass": 39592.0,
        "length": 366,
        "protein_name": "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial",
        "gene_name": "IDH3A",
        "organism": "Human",
        "refseq_name": "isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor",
        "refseq_ac": [
            {
                "id": "NP_005521",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005521",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IDH3A",
        "gene_names_refseq": "IDH3A; RP90",
        "protein_names_uniprotkb": "Isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; 1.1.1.41; Isocitric dehydrogenase subunit alpha; NAD(+)-specific ICDH subunit alpha",
        "protein_names_refseq": "H-IDH alpha; NAD(+)-specific ICDH subunit alpha; NAD(H)-specific isocitrate dehydrogenase alpha subunit; NAD+-specific ICDH; isocitrate dehydrogenase (NAD(+)) 3 alpha; isocitrate dehydrogenase (NAD+) alpha chain; isocitrate dehydrogenase 3 (NAD(+)) alpha; isocitrate dehydrogenase 3 (NAD+) alpha; isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial precursor; isocitrate dehydrogenase [NAD] subunit alpha, mitochondrial; isocitric dehydrogenase subunit alpha",
        "tax_id": 9606,
        "disease": "early infantile epileptic encephalopathy (Disease Ontology:DOID:0050709); retinitis pigmentosa 90 (Disease Ontology:DOID:0112147); neuromuscular junction disease (Disease Ontology:DOID:439)",
        "pathway": " (hsa:3419);  (R-HSA-71403);  (R-HSA-9837999)",
        "pathway_count": 3,
        "publication_count": 139,
        "publication_id_list": "1052766;10673423;10727444;11237011;11278619;11923310;12198491;12207025;13181903;14249115;14555658;14623864;14832224;14946179;15234968;15522782;15652751;15870080;15877282;15987702;16115876;16143825;16737955;16740313;17101804;17182618;17297443;17432878;17579211;17668387;18806796;18914071;1946331;19608861;19841671;2005110;20068231;20435888;20847235;22262461;22710082;23201127;23564345;23747254;23931759;24315374;24520911;25564869;25576301;25802875;25892735;26154972;26504172;26923599;27189937;27374498;27496948;27600516;27642048;27920218;28058510;28063628;28098230;28139779;28218747;28228285;28377575;28396416;28412069;28832583;28887308;28904123;29242379;29301859;29351928;29393594;29437277;29557506;29632046;29632711;29769354;29932645;30058936;30120231;30315122;30761759;30844107;31012789;31222486;31327635;31530632;31695197;31844290;31998317;32157095;32357974;32387766;32488085;32938616;32983136;33058874;33141586;33257573;33298915;33392160;33537174;33912179;33936100;33968037;34087483;34229054;34269949;34357683;34509645;34704252;34943861;35051231;35154160;35318648;35366151;35463978;35580925;35870450;36139014;36241641;36420423;36629048;38665916;40596516;40914422;7623837;7755589;8200987;8616157;9765290;9765291;9792106;9792662;9809442",
        "class_list": "",
        "function": "Association between IDH mutational status and tumor-associated epilepsy or venous thromboembolism in patients with grade II and III astrocytoma., [RefSeq, PubMed]; Catalytic subunit of the enzyme which catalyzes the decarboxylation of isocitrate (ICT) into alpha-ketoglutarate. The heterodimer composed of the alpha (IDH3A) and beta (IDH3B) subunits and the heterodimer composed of the alpha (IDH3A) and gamma (IDH3G) subunits, have considerable basal activity but the full activity of the heterotetramer (containing two subunits of IDH3A, one of IDH3B and one of IDH3G) requires the assembly and cooperative function of both heterodimers., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. NAD(+)-dependent isocitrate dehydrogenases catalyze the allosterically regulated rate-limiting step of the tricarboxylic acid cycle. Each isozyme is a heterotetramer that is composed of two alpha subunits, one beta subunit, and one gamma subunit. The protein encoded by this gene is the alpha subunit of one isozyme of NAD(+)-dependent isocitrate dehydrogenase. [provided by RefSeq, Jul 2008]., [RefSeq]; Subcellular Proteome Analysis Reveals Apoptotic Vulnerability of T-Cell Acute Lymphoblastic Leukemia. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DW83;Q9H3X0",
        "ec_number_list": [
            {
                "id": "2.3.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1",
                "type": "external"
            },
            {
                "id": "7.1.1.2",
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                "id": "3.6.4.10",
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            {
                "id": "7.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.2.2",
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                "id": "4.2.1.2",
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                "id": "1.2.4.1",
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                "id": "5.6.1.7",
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                "id": "4.98.1.1",
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                "id": "2.7.11.-",
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                "id": "3.4.21.92",
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                "id": "1.1.1.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.35",
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                "id": "6.2.1.-",
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                "id": "4.2.1.3",
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                "id": "1.3.8.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5",
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            }
        ],
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0051287 NAD binding;GO:0004449 isocitrate dehydrogenase (NAD+) activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0045242 isocitrate dehydrogenase complex (NAD+)",
        "go_biological_process": "GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process;GO:0005975 carbohydrate metabolic process",
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                "id": "NP_001128523",
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        "protein_names_refseq": "FHF complex subunit HOOK interacting protein 2A isoform b; family with sequence similarity 160 member B1; protein FAM160B1",
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        "pathway": " (hsa:57700)",
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        "publication_id_list": "11237011;22424782;23301498;23481700;24029068;24366607;25576301;25880248;25892735;26154972;26992070;27090790;27397612;27846572;27862975;28228285;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632711;29769354;29786170;30315122;30429286;30484775;31154438;31353455;31530632;31844290;31848261;31937595;31998317;32157095;32357974;32387766;32488085;32502341;32938616;32983136;33123756;33141586;33298915;33392160;33592498;33717175;33912179;33968037;33981976;34087483;34171305;34211107;34357683;34509645;34561969;34932366;35051231;35251023;35580925;36010968;36215666;36241641;36581221;38665916",
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        "function": "Required for proper functioning of the nervous system., [UniProtKB, PubMed]",
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        "protein_name": "Probable E3 ubiquitin-protein ligase HERC3",
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        "function": "E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates., [UniProtKB]; HERC3 directly targets RPL23A for ubiquitination degradation and further regulates Colorectal Cancer proliferation and the cell cycle. Publication Status: Online-Only, [RefSeq, PubMed]; HERC3 facilitates ERAD of select membrane proteins by recognizing membrane-spanning domains., [RefSeq, PubMed]; HERC3 negatively regulates NF-kappaB signaling by enhancing RelA subunit degradation., [RefSeq, PubMed]; HERC3 promotes YAP/TAZ stability and tumorigenesis independently of its ubiquitin ligase activity., [RefSeq, PubMed]; HERC3 regulates epithelial-mesenchymal transition by directly ubiquitination degradation EIF5A2 and inhibits metastasis of colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member the HERC ubiquitin ligase family. The encoded protein is located in the cytosol and binds ubiquitin via a HECT domain. Mutations in this gene have been associated with colorectal and gastric carcinomas. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Oct 2012]., [RefSeq]; We found somatic mutations of HERC2, HERC3, TRIP12, UBE2Q1 and UBE4B genes in gastric carcinoma and colorectal carcinomas with microsatellite instability, [RefSeq, PubMed]",
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                "id": "2.3.2.24",
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                "id": "2.3.2.23",
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                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
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        "uniprot_id": [
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                "id": "UACA_HUMAN",
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        "mass": 162505.0,
        "length": 1416,
        "protein_name": "Uveal autoantigen with coiled-coil domains and ankyrin repeats",
        "gene_name": "UACA",
        "organism": "Human",
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        "refseq_ac": [
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                "id": "NP_001008225",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008225",
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        ],
        "gene_names_uniprotkb": "UACA; KIAA1561",
        "gene_names_refseq": "NUCLING; UACA",
        "protein_names_uniprotkb": "Uveal autoantigen with coiled-coil domains and ankyrin repeats",
        "protein_names_refseq": "nuclear membrane binding protein; uveal autoantigen with coiled-coil domains and ankyrin repeats isoform 2",
        "tax_id": 9606,
        "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:55075);  (R-HSA-9013407);  (R-HSA-9627069)",
        "pathway_count": 3,
        "publication_count": 68,
        "publication_id_list": "10.1101/2023.09.13.557529;10949025;11162650;11237011;11368848;11408476;11809807;12620238;15271982;15302935;15358194;17028588;17064668;17322306;18083107;18083711;18767875;20068231;20184954;20851766;24367089;25218447;26992070;27600516;27846572;28411811;28510447;28832583;28834231;28904123;29242379;29510700;29557506;29786170;30379171;30410026;30429286;31217245;31844290;31871319;32157095;32357974;32387766;32488085;32897882;32938616;32983136;33392160;33592498;33912179;33968037;33981976;34019948;34087483;34171305;34185709;34405274;34509645;35051231;35494241;35580925;36010968;36215666;36284347;37217939;37938771;38665916;40596516",
        "class_list": "",
        "function": "Modulates isoactin dynamics to regulate the morphological alterations required for cell growth and motility. Interaction with ARF6 may modulate cell shape and motility after injury. May be involved in multiple neurite formation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Regulates APAF1 expression and plays an important role in the regulation of stress-induced apoptosis. Promotes apoptosis by regulating three pathways, apoptosome up-regulation, LGALS3/galectin-3 down-regulation and NF-kappa-B inactivation. Regulates the redistribution of APAF1 into the nucleus after proapoptotic stress. Down-regulates the expression of LGALS3 by inhibiting NFKB1 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a protein that contains ankyrin repeats and coiled coil domains and likely plays a role in apoptosis. Studies in rodents have implicated the encoded protein in the stimulation of apoptosis and the regulation of mammary gland involution, in which the mammary gland returns to its pre-pregnant state. This protein has also been proposed to negatively regulate apoptosis based on experiments in human cell lines in which the protein was shown to interact with PRKC apoptosis WT1 regulator protein, also known as PAR-4, and inhibit translocation of the PAR-4 receptor. Autoantibodies to this protein have been identified in human patients with panuveitis and Graves' disease. Differential expression of this gene has been observed in various human cancers. [provided by RefSeq, May 2017]., [RefSeq]; UACA is a novel candidate for eye muscle autoantigens in thyroid-associated ophthalmopathy, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "G3XAG2;Q14DD3;Q8N3B8;Q96NH6;Q9HCL1;Q9NWC6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0050728 negative regulation of inflammatory response;GO:0008630 intrinsic apoptotic signaling pathway in response to DNA damage;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction;GO:0008631 intrinsic apoptotic signaling pathway in response to oxidative stress",
        "synthesized_glycan_count": 0,
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        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000001.000.00000",
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    },
    {
        "uniprot_canonical_ac": "Q96PV7-1",
        "uniprot_id": [
            {
                "id": "F193B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96PV7",
                "type": "external"
            }
        ],
        "mass": 96543.0,
        "length": 902,
        "protein_name": "Protein FAM193B",
        "gene_name": "FAM193B",
        "organism": "Human",
        "refseq_name": "protein FAM193B isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001177875",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177875",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM193B; IRIZIO; KIAA1931",
        "gene_names_refseq": "FAM193B; IRIZIO",
        "protein_names_uniprotkb": "Protein FAM193B",
        "protein_names_refseq": "protein FAM193B isoform 1; protein FAM193B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54540)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;21177767;23186163;23301498;24715725;25505266;25576301;26188516;26992070;27846572;27920218;28832583;29508533;30192525;31848261;32157095;32387766;32488085;32938616;33298915;34171305;34185709;34518442;35051231;36010968;36215666",
        "class_list": "",
        "function": "Expression of full length IRIZIO cDNA also cooperated with PAX3-FOXO1 in the transformation of Arf-/- myoblasts. Given that IRIZIO is expressed at increased levels in rhabdomyosarcoma, it might contribute to rhabdomyosarcomagenesis in humans., [RefSeq, PubMed]; Identification of FAM193b as KCTD5 interaction partner. Formation of trimeric complexes of KCTD5/cullin3 with MCM7, ZNF711 and FAM193B., [RefSeq, PubMed]; The ceRNA PVT1 inhibits proliferation of ccRCC cells by sponging miR-328-3p to elevate FAM193B expression., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "E9PET5;Q9NW00",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm",
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        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q96PV7-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96M60-1",
        "uniprot_id": [
            {
                "id": "F227B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96M60",
                "type": "external"
            }
        ],
        "mass": 59956.0,
        "length": 508,
        "protein_name": "Protein FAM227B",
        "gene_name": "FAM227B",
        "organism": "Human",
        "refseq_name": "protein FAM227B isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001317222",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317222",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM227B; C15orf33",
        "gene_names_refseq": "C15orf33; FAM227B",
        "protein_names_uniprotkb": "Protein FAM227B",
        "protein_names_refseq": "protein FAM227B isoform 2; protein FAM227B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:196951)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;32938616;33298915;33592498;34105348;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q86WS2",
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        "synthesized_glycan_count": 0,
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        "record_id": "Q96M60-1",
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        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O94927-1",
        "uniprot_id": [
            {
                "id": "HAUS5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O94927",
                "type": "external"
            }
        ],
        "mass": 71682.0,
        "length": 633,
        "protein_name": "HAUS augmin-like complex subunit 5",
        "gene_name": "HAUS5",
        "organism": "Human",
        "refseq_name": "HAUS augmin-like complex subunit 5",
        "refseq_ac": [
            {
                "id": "NP_056117",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056117",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HAUS5; KIAA0841",
        "gene_names_refseq": "HAUS5; KIAA0841; dgt5",
        "protein_names_uniprotkb": "HAUS augmin-like complex subunit 5",
        "protein_names_refseq": "HAUS augmin-like complex subunit 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23354);  (R-HSA-2565942);  (R-HSA-380259);  (R-HSA-380270);  (R-HSA-380284);  (R-HSA-380320);  (R-HSA-5620912);  (R-HSA-8854518)",
        "pathway_count": 8,
        "publication_count": 110,
        "publication_id_list": "11076968;11237011;11956313;12207013;12221128;12364337;12852856;13678582;14580337;15498487;15705883;16357211;16462731;16890155;17574030;17646400;17719545;18037885;18378770;18477460;18521620;18566290;18615013;18694559;18801063;19004860;19081074;19369198;19427217;19940019;20230748;20308558;20399632;20558667;21273506;21347367;21422230;21548880;21565611;21620453;21725307;21792235;22094468;22179047;22365832;22433857;22641346;22653444;23141531;23141541;23186163;23253480;23348840;23400999;23481700;23530209;23747070;23769972;23789104;23921553;24053599;24089205;24231678;24469809;24982133;25047611;25313408;25418920;25532896;25576301;26811146;26992070;27920218;28218747;28228285;28596487;28832583;28904123;29242379;29393594;29437277;29493099;29632046;29786170;30429286;30459171;30723163;31530632;31844290;32157095;32265295;32387766;32502341;32938616;33141586;33298915;33402344;33592498;33691108;33968037;33981976;34019948;34509645;35051231;36010968;36241641;36765148;7769006;7790358;8838651",
        "class_list": "",
        "function": "Comprehensive analysis of the correlation of the pan-cancer gene HAUS5 with prognosis and immune infiltration in liver cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Contributes to mitotic spindle assembly, maintenance of centrosome integrity and completion of cytokinesis as part of the HAUS augmin-like complex., [UniProtKB, PubMed, PubMed]; HAUS5 is 1 of 8 subunits of the 390-kD human augmin complex, or HAUS complex. The augmin complex was first identified in Drosophila, and its name comes from the Latin verb 'augmentare,' meaning 'to increase.' The augmin complex is a microtubule-binding complex involved in microtubule generation within the mitotic spindle and is vital to mitotic spindle assembly (Goshima et al., 2008 [PubMed 18443220]; Uehara et al., 2009 [PubMed 19369198]).[supplied by OMIM, Jun 2010]., [RefSeq]; Our results suggest that GSCs differentially rely on ZNF131-dependent expression of HAUS5 as well as the Augmin/HAUS complex activity to maintain the integrity of centrosome function and viability., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "total_reported_o_glycosites": 2,
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        "total_reported_s_glycosites": 0,
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        "reported_snv": 8,
        "reported_interactions": 0,
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        "biomarker_type": "",
        "glycan_count": 2,
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        "glyco_site_count": 1,
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        "secondary_ac_list": "B2RXK1;Q6P2P7;Q7L3D5;Q96CT8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005829 cytosol;GO:0070652 HAUS complex;GO:1990498 mitotic spindle microtubule",
        "go_biological_process": "GO:0010968 regulation of microtubule nucleation;GO:0051301 cell division;GO:0007098 centrosome cycle;GO:0051225 spindle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "O94927-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NHX9-1",
        "uniprot_id": [
            {
                "id": "TPC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NHX9",
                "type": "external"
            }
        ],
        "mass": 85243.0,
        "length": 752,
        "protein_name": "Two pore channel protein 2",
        "gene_name": "TPCN2",
        "organism": "Human",
        "refseq_name": "two pore channel protein 2",
        "refseq_ac": [
            {
                "id": "NP_620714",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620714",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TPCN2; TPC2",
        "gene_names_refseq": "SHEP10; TPC2; TPCN2",
        "protein_names_uniprotkb": "Two pore channel protein 2; Two pore calcium channel protein 2",
        "protein_names_refseq": "two pore calcium channel protein 2; two pore channel protein 2; voltage-dependent calcium channel protein TPC2",
        "tax_id": 9606,
        "disease": "pigmentation disease (Disease Ontology:DOID:10123); brain infarction (Disease Ontology:DOID:3454)",
        "pathway": " (hsa:219931);  (R-HSA-2672351)",
        "pathway_count": 2,
        "publication_count": 125,
        "publication_id_list": "10564087;10642508;10720933;10767424;10830164;10831588;11182090;11237011;11588175;11687798;11734858;11842292;11904445;11956057;12393854;12907679;1379744;14584882;14634667;15010458;15044642;15147738;15318163;15504734;15505377;15916532;15919655;16219661;16813530;16849430;16850186;17381423;17448995;17699613;17881003;18000046;18063579;18310267;18400985;18449189;18488028;18508966;18662336;18724360;19153159;19307298;19380724;19387438;19620632;19808995;19953639;20388639;20466723;20525693;20538786;20880839;21040849;21527911;21984732;22002868;22012985;22773952;22946059;2298749;23063126;23112050;2321095;23394946;23616951;24188827;24502975;24776928;2536303;25722412;26359375;26562072;26838264;26992070;27140606;28071645;28154142;28790369;28904123;29242379;29437277;30484775;30860481;31825310;31844290;32157095;32167471;32221306;32357974;32387766;32488085;32502341;32679067;32938616;32983136;33465068;33795662;33875769;33912179;33968037;34171305;34362892;35051231;36241641;7588753;7665160;7795595;8041726;8112288;8383669;8533761;8544406;8626462;8809036;9037075;9395096;9571199;9662395;9700209;9719863;9744806",
        "class_list": "",
        "function": "(Microbial infection) During Ebola virus (EBOV) infection, controls the movement of endosomes containing virus particles and is required by EBOV to escape from the endosomal network into the cell cytoplasm., [UniProtKB, PubMed, UniProtKB, UniProtKB]; (Microbial infection) Required for cell entry of coronaviruses SARS-CoV and SARS-CoV-2, as well as human coronavirus EMC (HCoV-EMC), by endocytosis., [UniProtKB, PubMed]; Cryo-EM structure of human TPC2 provides insights into the mechanism of PI(3,5)P2-regulated gating of TPC2, which is distinct from that of TPC1 Publication Status: Online-Only, [RefSeq, PubMed]; Flavonoids increase melanin production and reduce proliferation, migration and invasion of melanoma cells by blocking endolysosomal/melanosomal TPC2. Publication Status: Online-Only, [RefSeq, PubMed]; Human genome diversity data reveal that L564P is the predominant TPC2 variant and a prerequisite for the blond hair associated M484L gain-of-function effect. Publication Status: Online-Only, [RefSeq, PubMed]; Intracellular channel initially characterized as a non-selective Ca(2+)-permeable channel activated by NAADP (nicotinic acid adenine dinucleotide phosphate), it is also a highly-selective Na(+) channel activated directly by PI(3,5)P2 (phosphatidylinositol 3,5-bisphosphate) (PubMed:19387438, PubMed:19620632, PubMed:20880839, PubMed:23063126, PubMed:23394946, PubMed:24502975, PubMed:24776928, PubMed:30860481, PubMed:31825310, PubMed:32167471). Localizes to the lysosomal and late endosome membranes where it regulates organellar membrane excitability, membrane trafficking, and pH homeostasis. Is associated with a plethora of physiological processes, including mTOR-dependent nutrient sensing, skin pigmentation and autophagy (PubMed:18488028, PubMed:23394946, PubMed:32167471). Ion selectivity is not fixed but rather agonist-dependent and under defined ionic conditions, can be readily activated by both NAADP and PI(3,5)P2 (PubMed:24502975, PubMed:31825310, PubMed:32167471). As calcium channel, it increases the pH in the lysosomal lumen, as sodium channel, it promotes lysosomal exocytosis (PubMed:31825310, PubMed:32167471). Plays a crucial role in endolysosomal trafficking in the endolysosomal degradation pathway and is potentially involved in the homeostatic control of many macromolecules and cell metabolites (By similarity) (PubMed:18488028, PubMed:19387438, PubMed:19620632, PubMed:20880839, PubMed:23063126, PubMed:23394946, PubMed:24502975, PubMed:24776928, PubMed:31825310, PubMed:32167471, PubMed:32679067). Also expressed in melanosomes of pigmented cells where mediates a Ca(2+) channel and/or PI(3,5)P2-activated melanosomal Na(+) channel to acidify pH and inhibit tyrosinase activity required for melanogenesis and pigmentation (PubMed:27140606). Unlike the voltage-dependent TPCN1, TPCN2 is voltage independent and can be activated solely by PI(3,5)P2 binding. In contrast, PI(4,5)P2, PI(3,4)P2, PI(3)P and PI(5)P have no obvious effect on channel activation (PubMed:30860481)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a putative cation-selective ion channel with two repeats of a six-transmembrane-domain. The protein localizes to lysosomal membranes and enables nicotinic acid adenine dinucleotide phosphate (NAADP) -induced calcium ion release from lysosome-related stores. This ubiquitously expressed gene has elevated expression in liver and kidney. Two common nonsynonymous SNPs in this gene strongly associate with blond versus brown hair pigmentation.[provided by RefSeq, Dec 2009]., [RefSeq]; Two coding variants in TPCN2 are associated with hair color, and a variant at the ASIP locus shows strong association with skin sensitivity to sun, freckling and red hair. GeneRIF: Genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
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        "reported_mutagensis": 9,
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        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NT82",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0072345 NAADP-sensitive calcium-release channel activity;GO:0005262 calcium channel activity;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0080025 phosphatidylinositol-3,5-bisphosphate binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005764 lysosome;GO:0005765 lysosomal membrane;GO:0031902 late endosome membrane;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0010506 regulation of autophagy;GO:0019722 calcium-mediated signaling;GO:0006874 intracellular calcium ion homeostasis;GO:0034220 monoatomic ion transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "Q8NHX9-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y3B2-1",
        "uniprot_id": [
            {
                "id": "EXOS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y3B2",
                "type": "external"
            }
        ],
        "mass": 21452.0,
        "length": 195,
        "protein_name": "Exosome complex component CSL4",
        "gene_name": "EXOSC1",
        "organism": "Human",
        "refseq_name": "exosome complex component CSL4 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001305291",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305291",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EXOSC1; CGI-108; CSL4",
        "gene_names_refseq": "CGI-108; CSL4; Csl4p; EXOSC1; PCH1F; SKI4; Ski4p; p13",
        "protein_names_uniprotkb": "Exosome complex component CSL4; Exosome component 1",
        "protein_names_refseq": "3'-5' exoribonuclease CSL4 homolog; exosomal core protein CSL4; exosome complex component CSL4 isoform b; homolog of yeast exosomal core protein CSL4",
        "tax_id": 9606,
        "disease": "pontocerebellar hypoplasia type 1F (Disease Ontology:DOID:0112331); microcephaly (Disease Ontology:DOID:10907); scleral disease (Disease Ontology:DOID:11343); dilated cardiomyopathy (Disease Ontology:DOID:12930)",
        "pathway": " (hsa:51013);  (R-HSA-380994);  (R-HSA-429958);  (R-HSA-450385);  (R-HSA-450513);  (R-HSA-450604);  (R-HSA-6791226);  (R-HSA-9930044)",
        "pathway_count": 8,
        "publication_count": 183,
        "publication_id_list": "10330172;10958673;11237011;11283721;11719186;11812149;11922599;12068309;12150911;12198173;12324455;12419256;12639954;12646273;12705825;12748283;14688255;14742429;14749774;14976220;15014438;15068804;15117938;15175153;15231747;15273322;15385533;15475613;15514971;15538381;15687258;15769464;15944294;16037817;16043514;16141059;16262601;16364914;16648466;16687408;16738141;16912112;16931790;16989641;17030608;17133347;17174896;17189298;17245413;17353269;17369404;17412707;17545563;18065403;18285520;18326031;18367721;18438418;18441014;18481987;18669648;18684992;18691976;18840095;19060886;19106111;19141871;19198587;19225159;19239894;19332556;19564402;19729507;19801658;19854161;20022965;20038530;20056613;20068231;20361218;20531386;20531389;20798176;20805244;20819938;21036871;21063389;21097556;21705430;21791617;21855801;22068837;22072790;22190735;22195017;22802018;22819556;22916032;22978410;23186163;23223233;23269699;23439679;23482395;2388630;24424021;24550520;24715725;25418920;25525153;25576301;25578728;25880248;25892735;25969445;26154972;26237581;26375851;2663993;2664463;26992070;27434818;27846572;27871484;27920218;28228285;28510447;28832583;28834231;28904123;29242379;29298432;29314611;29331515;29393594;29413899;29493099;29557506;29632046;29786170;29906447;30192525;30315122;30410026;30429286;30524438;30779550;30833945;31530632;31844290;31848261;31950173;32157095;32161166;32265295;32357974;32387766;3260265;32897882;33119769;33141586;33463720;33592498;33717175;33767452;33912179;33913806;33936100;33968037;33981976;34171305;34185709;34229054;34932366;35051231;35318648;35580925;36010968;36241641;36284347;37875486;39894887;9482744",
        "class_list": "",
        "function": "Association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p, [RefSeq, PubMed]; Bi-allelic missense variant, p.Ser35Leu in EXOSC1 is associated with pontocerebellar hypoplasia. Review article, [RefSeq, PubMed]; Human exosome hCsl4p participates in RNA degradation., [RefSeq, PubMed]; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes. EXOSC1 as peripheral part of the Exo-9 complex stabilizes the hexameric ring of RNase PH-domain subunits through contacts with EXOSC6 and EXOSC8., [UniProtKB]; Post-transcriptional control of cellular differentiation by the RNA exosome complex. Review article, [RefSeq, PubMed]; Protein-protein interactions between human exosome components support the assembly of RNase PH-type subunits into a six-membered PNPase-like ring., [RefSeq, PubMed]; This gene encodes a core component of the exosome. The mammalian exosome is required for rapid degradation of AU rich element-containing RNAs but not for poly(A) shortening. The association of this protein with the exosome is mediated by protein-protein interactions with ribosomal RNA-processing protein 42 and ribosomal RNA-processing protein 46. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9B3;Q5JTH3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006396 RNA processing;GO:0006364 rRNA processing;GO:0006401 RNA catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 18.6,
        "record_id": "Q9Y3B2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NEV8-1",
        "uniprot_id": [
            {
                "id": "EXPH5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NEV8",
                "type": "external"
            }
        ],
        "mass": 222520.0,
        "length": 1989,
        "protein_name": "Exophilin-5",
        "gene_name": "EXPH5",
        "organism": "Human",
        "refseq_name": "exophilin-5 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001294948",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001294948",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EXPH5; KIAA0624; SLAC2B",
        "gene_names_refseq": "EBS4; EXPH5; SLAC2-B; SLAC2B",
        "protein_names_uniprotkb": "Exophilin-5; SlaC2-b; Slp homolog lacking C2 domains b; Synaptotagmin-like protein homolog lacking C2 domains b",
        "protein_names_refseq": "exophilin-5 isoform 2; slp homolog lacking C2 domains b; synaptotagmin-like homologue lacking C2 domains b; synaptotagmin-like protein homolog lacking C2 domains b",
        "tax_id": 9606,
        "disease": "epidermolysis bullosa simplex (Disease Ontology:DOID:4644); epidermolysis bullosa simplex 4, localized or generalized intermediate, autosomal recessive (MONDO:MONDO:0014014)",
        "pathway": " (hsa:23086)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;11773082;12062444;17287340;19413330;23176819;23186163;24275569;25576301;27600516;28228285;28411811;28832583;29242379;29393594;31154438;32890627;33554392;36284347;36746116;37217939",
        "class_list": "",
        "function": "May act as Rab effector protein and play a role in vesicle trafficking., [UniProtKB]; Our findings identify an unexpected role for Slac2-b in inherited skin fragility and expand the clinical spectrum of human disorders of GTPase effector proteins., [RefSeq, PubMed]; Revealing EXPH5 as a potential diagnostic gene biomarker of the late stage of COPD based on machine learning analysis., [RefSeq, PubMed]; SLAC2B-dependent microtubule acetylation regulates extracellular matrix-mediated intracellular TM4SF5 traffic to the plasma membranes., [RefSeq, PubMed]; Slac2-b Coordinates Extracellular Vesicle Secretion to Regulate Keratinocyte Adhesion and Migration., [RefSeq, PubMed]; Slac2-b/KIAA0624 contains an N-terminal Slp homology domain (SHD) (PMID: 11327731). The SHD of Slac2-b specifically and directly binds the GTP-bound form of Rab27A (J. Biol. Chem. 277, (2002) 9212-9218; PMID: 11773082)., [RefSeq, PubMed]; The protein encoded by this gene is a member of the synaptotagmin-like protein (Slp) family lacking a C2 domain. It contains an N-terminal synaptotagmin-like homology domain (SHD), and is a ras-related protein Rab-27B effector protein. This protein is thought to be involved in exosome secretion and intracellular vesicle trafficking. Reduced expression of this gene results in keratin filament defects. Mutations in this gene have been associated with some cases of epidermolysis bullosa, an inherited skin fragility disorder. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_s_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "reported_phosphosites": 15,
        "reported_mutagensis": 0,
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        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2KHM1;Q9Y4D6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005768 endosome",
        "go_biological_process": "GO:0071985 multivesicular body sorting pathway;GO:0006886 intracellular protein transport;GO:0050714 positive regulation of protein secretion;GO:0003334 keratinocyte development;GO:0045921 positive regulation of exocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q8NEV8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IYU2-1",
        "uniprot_id": [
            {
                "id": "HACE1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IYU2",
                "type": "external"
            }
        ],
        "mass": 102342.0,
        "length": 909,
        "protein_name": "E3 ubiquitin-protein ligase HACE1",
        "gene_name": "HACE1",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase HACE1 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001308009",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308009",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HACE1; KIAA1320",
        "gene_names_refseq": "HACE1; SPPRS",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HACE1; 2.3.2.26; HECT domain and ankyrin repeat-containing E3 ubiquitin-protein ligase 1; HECT-type E3 ubiquitin transferase HACE1",
        "protein_names_refseq": "E3 ubiquitin-protein ligase HACE1 isoform b; HECT-type E3 ubiquitin transferase HACE1",
        "tax_id": 9606,
        "disease": "spastic paraplegia-severe developmental delay-epilepsy syndrome (MONDO:MONDO:0014764)",
        "pathway": " (hsa:57531);  (R-HSA-983168);  (R-HSA-9958825)",
        "pathway_count": 3,
        "publication_count": 75,
        "publication_id_list": "11062501;11237011;11350924;12646216;14734113;15224091;15224092;15254018;15571818;16595681;16849449;16954532;17694067;18555777;18630515;18662542;19028597;19352404;19452197;19489725;19851334;19874575;19940261;19948536;2183031;21988917;22036506;22117219;2261476;2405250;25576301;25880248;25892735;26424145;26437029;27600516;28317937;28832583;29242379;29362425;30192525;30779550;31154438;31844290;32157095;32161166;32357974;32938616;33298915;33392160;33537174;33592498;33691108;33968037;33981976;34215617;34357683;34815381;35051231;35580925;36010968;37537642;38070140;38332367;38364733;38790209;7510216;7512451;8140422;8234276;8626374;8662591;8662795;9380723;9668046",
        "class_list": "",
        "function": "A Missense Variant in HACE1 Is Associated with Intellectual Disability, Epilepsy, Spasticity, and Psychomotor Impairment in a Pakistani Kindred. Publication Status: Online-Only, [RefSeq, PubMed]; Aberrant methylation of the HACE1 gene was detected in 9 out of the 32 (28%) primary colon carcinomas., [RefSeq, PubMed]; E3 ubiquitin-protein ligase involved in Golgi membrane fusion and regulation of small GTPases (PubMed:15254018, PubMed:21988917, PubMed:22036506, PubMed:37537642, PubMed:38332367). Acts as a regulator of Golgi membrane dynamics during the cell cycle: recruited to Golgi membrane by Rab proteins and regulates postmitotic Golgi membrane fusion (PubMed:21988917). Acts by mediating ubiquitination during mitotic Golgi disassembly, ubiquitination serving as a signal for Golgi reassembly later, after cell division (PubMed:21988917). Specifically binds GTP-bound RAC1, mediating ubiquitination and subsequent degradation of active RAC1, thereby playing a role in host defense against pathogens (PubMed:22036506, PubMed:37537642, PubMed:38332367). May also act as a transcription regulator via its interaction with RARB (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Emerging role and mechanism of HACE1 in the pathogenesis of neurodegenerative diseases: A promising target. Review article, [RefSeq, PubMed]; HACE1 expression in heart failure patients might promote mitochondrial oxidative stress and ferroptosis by targeting NRF2., [RefSeq, PubMed]; HACE1 is a candidate chromosome 6q21 tumor-suppressor gene involved in multiple cancers., [RefSeq, PubMed]; HACE1-mediated NRF2 activation causes enhanced malignant phenotypes and decreased radiosensitivity of glioma cells. Publication Status: Online-Only, [RefSeq, PubMed]; Hace1 as a novel ubiquitin-protein ligase with very low expression Wilms' tumors; hypermethylation of two upstream CpG islands correlates with low HACE1 expression in tumor samples., [RefSeq, PubMed]; Structural Basis for the Enzymatic Activity of the HACE1 HECT-Type E3 Ligase Through N-Terminal Helix Dimerization., [RefSeq, PubMed]; This gene encodes a HECT domain and ankyrin repeat-containing ubiquitin ligase. The encoded protein is involved in specific tagging of target proteins, leading to their subcellular localization or proteasomal degradation. The protein is a potential tumor suppressor and is involved in the pathophysiology of several tumors, including Wilm's tumor. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "predicted_c_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
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        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 22,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6U5;B3KY89;B4DFM6;B4DTQ4;B7Z9X6;E9PGP0;Q5VU99;Q5VUA0;Q8ND12;Q9P2M6",
        "ec_number_list": [
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity;GO:0031267 small GTPase binding;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0032580 Golgi cisterna membrane",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016601 Rac protein signal transduction;GO:0016567 protein ubiquitination;GO:0030334 regulation of cell migration;GO:0061025 membrane fusion",
        "synthesized_glycan_count": 0,
        "hit_score": 7.6,
        "record_id": "Q8IYU2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q68CP4-1",
        "uniprot_id": [
            {
                "id": "HGNAT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q68CP4",
                "type": "external"
            }
        ],
        "mass": 73293.0,
        "length": 663,
        "protein_name": "Heparan-alpha-glucosaminide N-acetyltransferase",
        "gene_name": "HGSNAT",
        "organism": "Human",
        "refseq_name": "heparan-alpha-glucosaminide N-acetyltransferase isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_689632",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689632",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HGSNAT; TMEM76",
        "gene_names_refseq": "HGNAT; HGSNAT; MPS3C; RP73; TMEM76",
        "protein_names_uniprotkb": "Heparan-alpha-glucosaminide N-acetyltransferase; 2.3.1.78; Transmembrane protein 76",
        "protein_names_refseq": "heparan-alpha-glucosaminide N-acetyltransferase isoform 1 precursor; transmembrane protein 76",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa 73 (Disease Ontology:DOID:0110389); mucopolysaccharidosis type IIIC (Disease Ontology:DOID:0111393); mucopolysaccharidosis III (Disease Ontology:DOID:12801)",
        "pathway": " (hsa:138050);  (R-HSA-2024096);  (R-HSA-2206291);  (R-HSA-6798695)",
        "pathway_count": 4,
        "publication_count": 75,
        "publication_id_list": "10.1101/2023.09.13.557529;10446189;10466419;11027606;11237011;12213822;12441129;12927802;15647514;16151907;16960811;17033958;17397050;17897319;18024218;19159218;1946389;19479962;19823584;20068231;20560209;20560210;20576607;20583299;20650889;20825431;2122463;22645359;23186163;23650620;24190977;24715725;25502872;25859010;25892735;26992070;27920218;28101780;28218747;28228285;29393594;29437277;29493099;29557506;29632711;29741879;29769354;29786170;30410026;31844290;32161166;32350084;32770643;32938616;33123756;33298915;33633747;33912179;33968037;34171305;34357683;35051231;35154160;35580925;36241641;36284347;37014526;37074911;37592806;38613342;38665916;7493035;8692836;8776591;9285796",
        "class_list": "glycogene",
        "function": "A genetic and clinical study of individuals with nonsyndromic retinopathy consequent upon sequence variants in HGSNAT, the gene associated with Sanfilippo C mucopolysaccharidosis., [RefSeq, PubMed]; Expanding the phenotypic and genotypic spectrum of patients with HGSNAT-related retinopathy., [RefSeq, PubMed]; Gene encoding the enzyme deficient in mucopolysaccharidosis IIIC was identified as HGSNAT; mutational analyses identified a splice-junction mutation that accounted for three mutant alleles, and a single base-pair insertion accounted for the fourth, [RefSeq, PubMed]; Identification and characterization of novel genetic variants in the first Chinese family of mucopolysaccharidosis IIIC (Sanfilippo C syndrome)., [RefSeq, PubMed]; Lysosomal acetyltransferase that acetylates the non-reducing terminal alpha-glucosamine residue of intralysosomal heparin or heparan sulfate, converting it into a substrate for luminal alpha-N-acetyl glucosaminidase., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Mucopolysaccharidosis type IIIC in chinese mainland: clinical and molecular characteristics of ten patients and report of six novel variants in the HGSNAT gene., [RefSeq, PubMed]; This gene encodes a lysosomal acetyltransferase, which is one of several enzymes involved in the lysosomal degradation of heparin sulfate. Mutations in this gene are associated with Sanfilippo syndrome C, one type of the lysosomal storage disease mucopolysaccaridosis III, which results from impaired degradation of heparan sulfate. [provided by RefSeq, Jan 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_n_glycosites": 5,
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        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
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        "total_n_glycosites": 5,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 20,
        "disease_count": 3,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E2V0",
        "ec_number_list": [
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                "id": "3.4.24.81",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78",
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        ],
        "go_molecular_function": "GO:0016746 acyltransferase activity;GO:0015019 heparan-alpha-glucosaminide N-acetyltransferase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0035579 specific granule membrane;GO:0070821 tertiary granule membrane;GO:0005765 lysosomal membrane;GO:0043202 lysosomal lumen",
        "go_biological_process": "GO:0051259 protein complex oligomerization;GO:0007041 lysosomal transport;GO:0030200 heparan sulfate proteoglycan catabolic process",
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    {
        "uniprot_canonical_ac": "A2PYH4-1",
        "uniprot_id": [
            {
                "id": "HFM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A2PYH4",
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        ],
        "mass": 162610.0,
        "length": 1435,
        "protein_name": "Probable ATP-dependent DNA helicase HFM1",
        "gene_name": "HFM1",
        "organism": "Human",
        "refseq_name": "probable ATP-dependent DNA helicase HFM1",
        "refseq_ac": [
            {
                "id": "NP_001017975",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017975",
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        ],
        "gene_names_uniprotkb": "HFM1; SEC3D1",
        "gene_names_refseq": "HFM1; MER3; POF9; SEC63D1; Si-11-6; Si-11; helicase",
        "protein_names_uniprotkb": "Probable ATP-dependent DNA helicase HFM1; 5.6.2.4; DNA 3'-5' helicase HFM1; SEC63 domain-containing protein 1",
        "protein_names_refseq": "DNA 3'-5' helicase HFM1; HFM1, ATP dependent DNA helicase homolog; SEC63 domain-containing protein 1; helicase-like protein HFM1; probable ATP-dependent DNA helicase HFM1",
        "tax_id": 9606,
        "disease": "primary ovarian insufficiency 9 (Disease Ontology:DOID:0080866)",
        "pathway": " (hsa:164045)",
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        "publication_id_list": "11237011;17286053;20800603;24597873;26679638;29557506;30379171;31279343;33912179;34429122;34707299;35051231;35486194;35526155;35881270;37217939;37340703",
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        "function": "A novel heterozygous missense mutation in HFM1 (c.3470G > A) associated with premature ovarian insufficiency (POI) is in the affected family members and absent in the unaffected family members in China. Results of the minigene assay reveals that the mutation changes the mRNA splicing repertory. Publication Status: Online-Only, [RefSeq, PubMed]; Biallelic HFM1 variants cause non-obstructive azoospermia with meiotic arrest in humans by impairing crossover formation to varying degrees., [RefSeq, PubMed]; Data suggest that HFM1 gene might be associated with primary ovarian insufficiency in Chinese population., [RefSeq, PubMed]; Exome sequencing of two Chinese sisters with primary ovarian insufficiency and their parents identified a shared compound heterozygous mutation in a meiotic gene, HFM1, which encodes a protein necessary for homologous recombination of chromosomes., [RefSeq, PubMed]; HHFM1 is the evolutionally conserved putative human DNA helicase, which may function as a modulator for genome integrity in germ-line tissues., [RefSeq, PubMed]; Identification of a new splice-acceptor mutation in HFM1 and functional analysis through molecular docking in nonobstructive azoospermia., [RefSeq, PubMed]; Novel pathogenic splicing variants in helicase for meiosis 1 (HFM1) are associated with diminished ovarian reserve and poor pregnancy outcomes., [RefSeq, PubMed]; Novel variants in helicase for meiosis 1 lead to male infertility due to non-obstructive azoospermia. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Required for crossover formation and complete synapsis of homologous chromosomes during meiosis., [UniProtKB, UniProtKB]; The protein encoded by this gene is thought to be an ATP-dependent DNA helicase and is expressed mainly in germ-line cells. Defects in this gene are a cause of premature ovarian failure 9 (POF9). [provided by RefSeq, Apr 2014]., [RefSeq]",
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        "reported_snv": 52,
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        "secondary_ac_list": "B1B0B6;Q8N9Q0",
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                "id": "3.6.1.-",
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                "id": "3.6.4.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
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                "id": "3.6.5.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
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                "id": "7.2.2.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
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                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
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                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
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        ],
        "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates",
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        "record_id": "A2PYH4-1",
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        "kg_view_protein": true
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        "mass": 132965.0,
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        "protein_name": "Protein FAM184A",
        "gene_name": "FAM184A",
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        "refseq_name": "protein FAM184A isoform 3",
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        "gene_names_refseq": "C6orf60; FAM184A",
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        "protein_names_refseq": "protein FAM184A isoform 3; protein FAM184A",
        "tax_id": 9606,
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        "secondary_ac_list": "B9DI75;F8W8D6;Q5TBS9;Q7Z323;Q96GY8;Q9H0J8;Q9H851",
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0000932 P-body;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body",
        "go_biological_process": "",
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        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IV04-1",
        "uniprot_id": [
            {
                "id": "TB10C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IV04",
                "type": "external"
            }
        ],
        "mass": 49712.0,
        "length": 446,
        "protein_name": "Carabin",
        "gene_name": "TBC1D10C",
        "organism": "Human",
        "refseq_name": "carabin isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001243437",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243437",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TBC1D10C",
        "gene_names_refseq": "CARABIN; EPI64C; TBC1D10C",
        "protein_names_uniprotkb": "Carabin; TBC1 domain family member 10C",
        "protein_names_refseq": "carabin isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:374403);  (R-HSA-6798695);  (R-HSA-8854214)",
        "pathway_count": 3,
        "publication_count": 63,
        "publication_id_list": "10202141;11237011;16055087;16395330;17230191;17658474;17901050;18199687;18319245;18466115;19913121;20058876;20095038;20116244;20363736;20404108;21383079;21458671;22219378;22613832;22762500;22795129;22854040;23019362;23109291;23562278;23650620;24714562;25880248;25892735;26375851;27846572;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437589;29493099;29508533;29557506;29632046;29632711;29786170;30429286;30524438;31844290;32157095;32265295;32357974;32488085;32502341;32897882;32983136;33691108;33717175;34932366;35051231;35425695;35580925;8692836",
        "class_list": "",
        "function": "Carabin as a new negative regulator of B-cell function, whose deficiency in B cells speeds up early B-cell responses, [RefSeq, PubMed]; Carabin is a negative feedback inhibitor of the calcineurin signalling pathway that also mediates crosstalk between calcineurin and Ras GeneRIF: Carabin inhibits calcineurin and Ras and was identified by a yeast-two-hybrid screen with calcineurin, [RefSeq, PubMed]; Identify prolyl 4-hydroxylase 2 (P4HA2) as a specific proline hydroxylase of Carabin. Carabin hydroxylation leads to its proteasomal degradation, thereby activating the Ras/extracellular signal-regulated kinase pathway and increasing B-cell lymphoma proliferation., [RefSeq, PubMed]; Inhibits the Ras signaling pathway through its intrinsic Ras GTPase-activating protein (GAP) activity. Acts as a negative feedback inhibitor of the calcineurin signaling pathway that also mediates crosstalk between calcineurin and Ras., [UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene has an N-terminal Rab-GTPase domain and a binding site at the C-terminus for calcineurin, and is an inhibitor of both the Ras signaling pathway and calcineurin, a phosphatase regulated by calcium and calmodulin. Genes encoding similar proteins are located on chromosomes 16 and 22. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2013]., [RefSeq]; Weighted Gene Coexpression Network Analysis Identifies TBC1D10C as a New Prognostic Biomarker for Breast Cancer. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "G3V1D6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0101003 ficolin-1-rich granule membrane;GO:0031527 filopodium membrane",
        "go_biological_process": "GO:0042147 retrograde transport, endosome to Golgi",
        "synthesized_glycan_count": 0,
        "hit_score": 6.4,
        "record_id": "Q8IV04-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P08397-1",
        "uniprot_id": [
            {
                "id": "HEM3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P08397",
                "type": "external"
            }
        ],
        "mass": 39330.0,
        "length": 361,
        "protein_name": "Porphobilinogen deaminase",
        "gene_name": "HMBS",
        "organism": "Human",
        "refseq_name": "porphobilinogen deaminase isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000181",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000181",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HMBS; PBGD; UPS",
        "gene_names_refseq": "ENCEP; HMBS; LENCEP; PBG-D; PBGD; PORC; UPS",
        "protein_names_uniprotkb": "Porphobilinogen deaminase; 2.5.1.61; HMBS; Hydroxymethylbilane synthase; PBG-D; Pre-uroporphyrinogen synthase",
        "protein_names_refseq": "Chester type; porphobilinogen deaminase isoform 1; porphobilinogen deaminase; porphyria, acute; pre-uroporphyrinogen synthase; uroporphyrinogen I synthase; uroporphyrinogen I synthetase",
        "tax_id": 9606,
        "disease": "prostate carcinoma (Disease Ontology:DOID:10286); sickle cell anemia (Disease Ontology:DOID:10923); urinary bladder cancer (Disease Ontology:DOID:11054); cancer (Disease Ontology:DOID:162); bilirubin metabolic disorder (Disease Ontology:DOID:2741); acute intermittent porphyria (Disease Ontology:DOID:3890); seminoma (Disease Ontology:DOID:4440); liver carcinoma (Disease Ontology:DOID:686); encephalopathy, porphyria-related (MONDO:MONDO:0958224); leukoencephalopathy, porphyria-related (MONDO:MONDO:0958226)",
        "pathway": " (hsa:3145);  (R-HSA-189451)",
        "pathway_count": 2,
        "publication_count": 117,
        "publication_id_list": "10453740;10494093;10502788;10602775;10657149;10706561;10782018;11013452;11030413;11032836;11032841;11175906;11237011;11399210;11857754;12372055;12406973;12474143;12773194;1301948;1427766;14669009;14757946;1496994;14970743;15235026;15669678;1577472;15863660;16121195;16176984;16211556;16258391;1714233;18004775;18406650;18936296;19138865;19207107;19292878;1939222;19413330;20705604;22223895;2243128;23186163;23467411;23815679;25645385;25703257;25870942;2609111;26154972;26992070;27558376;27920218;28218747;28228285;28510447;28514659;2875434;28834231;28904123;29242379;29360981;29437277;29493099;29557506;30315122;31844290;31848261;31998317;32157095;32350084;32357974;32916704;32938616;33298915;33968037;33981976;34019948;34087483;34089223;3422427;34523126;34681668;35251023;35580925;3805019;3816774;38568055;40914422;666752;6822570;7354069;7592565;7757070;7866402;7916736;7962538;8078902;8081367;8159699;8262523;8268934;8270254;8270256;8401516;8644733;8771201;8825929;9177788;9199558;9225970;9463797;9654202;9878253",
        "class_list": "",
        "function": "As part of the heme biosynthetic pathway, catalyzes the sequential polymerization of four molecules of porphobilinogen to form hydroxymethylbilane, also known as preuroporphyrinogen. Catalysis begins with the assembly of the dipyrromethane cofactor by the apoenzyme from two molecules of porphobilinogen or from preuroporphyrinogen. The covalently linked cofactor acts as a primer, around which the tetrapyrrole product is assembled. In the last step of catalysis, the product, preuroporphyrinogen, is released, leaving the cofactor bound to the holodeaminase intact., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Brain ventricular enlargement in human and murine acute intermittent porphyria., [RefSeq, PubMed]; Expanding the clinical and radiological phenotypes of leukoencephalopathy due to biallelic HMBS mutations., [RefSeq, PubMed]; Identification and molecular analysis of 17 novel variants of hydroxymethylbilane synthase in Chinese patients with acute intermittent porphyria., [RefSeq, PubMed]; Neurodevelopmental disorder in a patient with HMBS and SCN3A variants-A possibly blended phenotype further delineating autosomal recessive HMBS related disease., [RefSeq, PubMed]; This gene encodes a member of the hydroxymethylbilane synthase superfamily. The encoded protein is the third enzyme of the heme biosynthetic pathway and catalyzes the head to tail condensation of four porphobilinogen molecules into the linear hydroxymethylbilane. Mutations in this gene are associated with the autosomal dominant disease acute intermittent porphyria. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]; Two Novel Hydroxymethylbilane Synthase Splicing Mutations Predispose to Acute Intermittent Porphyria. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "A8K2L0;G3V1P4;G5EA58;P08396;Q16012",
        "ec_number_list": [
            {
                "id": "2.5.1.61",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.61",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004418 hydroxymethylbilane synthase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006783 heme biosynthetic process;GO:0006782 protoporphyrinogen IX biosynthetic process;GO:0006784 heme A biosynthetic process;GO:0006785 heme B biosynthetic process;GO:0006779 porphyrin-containing compound biosynthetic process",
        "synthesized_glycan_count": 0,
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        "record_id": "P08397-1",
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    {
        "uniprot_canonical_ac": "O60921-1",
        "uniprot_id": [
            {
                "id": "HUS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60921",
                "type": "external"
            }
        ],
        "mass": 31691.0,
        "length": 280,
        "protein_name": "Checkpoint protein HUS1",
        "gene_name": "HUS1",
        "organism": "Human",
        "refseq_name": "checkpoint protein HUS1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_004498",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004498",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HUS1",
        "gene_names_refseq": "HUS1; hHUS1",
        "protein_names_uniprotkb": "Checkpoint protein HUS1; hHUS1",
        "protein_names_refseq": "HUS1 checkpoint homolog; checkpoint protein HUS1 isoform 1; checkpoint protein HUS1; hus1+-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3364);  (R-HSA-176187);  (R-HSA-5685938);  (R-HSA-5693607);  (R-HSA-5693616);  (R-HSA-6804756);  (R-HSA-69473);  (R-HSA-9709570)",
        "pathway_count": 8,
        "publication_count": 195,
        "publication_id_list": "10051570;10212258;10359610;10373362;10373512;10435622;10438626;10500146;10551859;10570149;10570174;10604467;10673500;10673501;10710310;10733923;10744977;10777662;10827953;10846170;10859164;10884347;10884395;10921897;11077446;11080452;11139606;11237011;11239457;11301010;11376695;11390642;11447225;11511362;11546806;11551930;11571269;11573955;11698410;11740489;11751635;11780126;11832208;12064478;12139939;12152085;12191481;12226092;12228710;12370410;12379650;12393879;12399544;12545175;12578958;12676583;12676925;12702766;12750383;12759351;12791985;12851404;12914926;12963847;14500360;14576433;14603323;14605214;14611806;14624239;14702041;14734547;15053879;15189136;15190204;15226314;15314187;15359272;15485900;15556996;15665856;15703751;15707391;15743907;15833913;15866171;15871698;15897895;16148040;16153896;16216273;16322561;16327781;16360315;16407120;16530042;16885023;17108107;17349958;17515903;17575048;17591690;17928296;17962301;17965729;18171670;18317453;18452278;18480045;18490454;18539610;18541667;18757400;18805091;18923075;18971343;19121998;19357644;19419957;19965871;20154705;20233725;20729832;20729858;20729859;20959462;20965415;21052091;21240188;21263215;21317932;21325134;21335604;21565612;21659603;21680713;21777809;21804533;22021381;22024395;22194698;22231403;22635276;22661229;22661230;22792074;22977173;23000554;23149936;23345434;23468639;23485397;23676219;23810717;24013206;24145406;24874608;25113031;25122754;25558984;25659039;26145171;26992070;28832583;28834231;29242379;29557506;29786170;31154438;31776186;31844290;32157095;32938616;33137086;33592498;33711383;33912179;33978741;34171305;34440403;35051231;35580925;36172813;36841485;39894887;8196638;8702565;8943031;9278511;9278512;9524127;9705271;9837724;9878245;9925639",
        "class_list": "",
        "function": "Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:21659603). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603)., [UniProtKB, PubMed]; Functional study of the yeast homolog., [RefSeq, PubMed]; In vivo miRNA knockout screening identifies miR-190b as a novel tumor suppressor. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-340-3p-HUS1 axis suppresses proliferation and migration in lung adenocarcinoma cells., [RefSeq, PubMed]; The protein encoded by this gene is a component of an evolutionarily conserved, genotoxin-activated checkpoint complex that is involved in the cell cycle arrest in response to DNA damage. This protein forms a heterotrimeric complex with checkpoint proteins RAD9 and RAD1. In response to DNA damage, the trimeric complex interacts with another protein complex consisting of checkpoint protein RAD17 and four small subunits of the replication factor C (RFC), which loads the combined complex onto the chromatin. The DNA damage induced chromatin binding has been shown to depend on the activation of the checkpoint kinase ATM, and is thought to be an early checkpoint signaling event. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2011]., [RefSeq]",
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        "secondary_ac_list": "B4DFI9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0035861 site of double-strand break",
        "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0006281 DNA repair;GO:0000723 telomere maintenance;GO:0006974 DNA damage response;GO:0000724 double-strand break repair via homologous recombination",
        "synthesized_glycan_count": 0,
        "hit_score": 19.8,
        "record_id": "O60921-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q658Y4-1",
        "uniprot_id": [
            {
                "id": "F91A1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q658Y4",
                "type": "external"
            }
        ],
        "mass": 93909.0,
        "length": 838,
        "protein_name": "Protein FAM91A1",
        "gene_name": "FAM91A1",
        "organism": "Human",
        "refseq_name": "protein FAM91A1 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001304847",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304847",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM91A1",
        "gene_names_refseq": "FAM91A1",
        "protein_names_uniprotkb": "Protein FAM91A1",
        "protein_names_refseq": "protein FAM91A1 isoform 3; protein FAM91A1; skeletal muscle cells re-entry induced",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:157769);  (R-HSA-9013407)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "11237011;11368848;11809807;15302935;17028588;17064668;18220336;18669648;18691976;19651622;20068231;20184954;20851766;23186163;24275569;24715725;25576301;25645385;25880248;27600516;28218747;28514659;28832583;28904123;29084197;29242379;29393594;29426865;29437277;29510700;29557506;29602958;29605689;29786170;30315122;30429286;30833945;31154438;31217245;31844290;31871319;32157095;32161166;32357974;32488085;32502341;32938616;32983136;33298915;33592498;33691108;33912179;33968037;34087483;34185709;34357683;35051231;35318648;35580925;36010968;37217939;37903274;40914422",
        "class_list": "",
        "function": "As component of the WDR11 complex acts together with TBC1D23 to facilitate the golgin-mediated capture of vesicles generated using AP-1., [UniProtKB, PubMed]; FAM91A1-TBC1D23 complex structure reveals human genetic variations susceptible for PCH., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B6YY23;Q658T5;Q8TE89",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0031410 cytoplasmic vesicle;GO:0005802 trans-Golgi network",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0099041 vesicle tethering to Golgi",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q658Y4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96MK3-1",
        "uniprot_id": [
            {
                "id": "FA20A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96MK3",
                "type": "external"
            }
        ],
        "mass": 61417.0,
        "length": 541,
        "protein_name": "Pseudokinase FAM20A",
        "gene_name": "FAM20A",
        "organism": "Human",
        "refseq_name": "pseudokinase FAM20A isoform b",
        "refseq_ac": [
            {
                "id": "NP_001230675",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230675",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM20A; PRO34279",
        "gene_names_refseq": "AI1G; AIGFS; FAM20A; FP2747",
        "protein_names_uniprotkb": "Pseudokinase FAM20A",
        "protein_names_refseq": "family with sequence similarity 20, member A; protein FAM20A; pseudokinase FAM20A isoform b; pseudokinase FAM20A",
        "tax_id": 9606,
        "disease": "amelogenesis imperfecta type 1G (Disease Ontology:DOID:0110066)",
        "pathway": " (hsa:54757);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 3,
        "publication_count": 84,
        "publication_id_list": "10026136;10077652;10218588;10512690;10614670;10681634;10810289;10898936;10912521;10951195;10990447;11158056;11237011;11250653;11264294;11316783;11522292;11606061;11739083;11751371;11788658;12241545;12379487;12466191;12810533;12904166;12975309;1370451;1383255;15126567;15308688;15469690;15485880;15525596;15642270;15676076;17047378;17249697;17312271;17985932;21549343;21990045;23434854;23468644;23697977;24196488;24259279;24756937;2476804;2479552;25636655;25789606;25827751;26091039;30459171;32835847;32983136;33968037;35580925;36650945;37074911;37159186;38499693;38546520;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;8781553;8817670;8894645;8964575;9497324;9709957;9733769;9786878;9922210",
        "class_list": "",
        "function": "Deep dental phenotyping and a novel FAM20A variant in patients with amelogenesis imperfecta type IG., [RefSeq, PubMed]; FAM20A is a golgi-localized Type II transmembrane protein. Publication Status: Online-Only, [RefSeq, PubMed]; FAM20A mutations and transcriptome analyses of dental pulp tissues of enamel renal syndrome., [RefSeq, PubMed]; FAM20A-Associated Amelogenesis Imperfecta: Gene Variants with Functional Verification and Histological Features., [RefSeq, PubMed]; Pseudokinase that acts as an allosteric activator of the Golgi serine/threonine protein kinase FAM20C and is involved in biomineralization of teeth. Forms a complex with FAM20C and increases the ability of FAM20C to phosphorylate the proteins that form the 'matrix' that guides the deposition of the enamel minerals., [UniProtKB, PubMed]; This locus encodes a protein that is likely secreted and may function in hematopoiesis. A mutation at this locus has been associated with amelogenesis imperfecta and gingival hyperplasia syndrome. Alternatively spliced transcript variants have been identified. [provided by RefSeq, Aug 2011]., [RefSeq]; Three homozygous mutations in three families, and a compound heterozygous mutation in one family with hypoplastic amelogenesis imperfecta have been identified in FAM20A., [RefSeq, PubMed]; Two new families with enamel renal syndrome: A novel FAM20A gene mutation and review of literature. Review article, [RefSeq, PubMed]; We identified a homozygous nonsense mutation in exon 2 of FAM20A that was not present in the Single Nucleotide Polymorphism database (dbSNP), the 1000 Genomes database, or the Centre d'Etude du Polymorphisme Humain (CEPH) Diversity Panel. GeneRIF: A homozygous nonsense mutation in exon 2 of FAM20A underlies Amelogenesis imperfecta (AI) -- disorders of biomineralization resulting from failure of normal enamel formation., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RN47;B2RN49;Q9UF95",
        "ec_number_list": [],
        "go_molecular_function": "GO:0043539 protein serine/threonine kinase activator activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0001934 positive regulation of protein phosphorylation;GO:0031214 biomineral tissue development;GO:0070166 enamel mineralization;GO:0055074 calcium ion homeostasis;GO:0044691 tooth eruption",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "Q96MK3-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P05019-1",
        "uniprot_id": [
            {
                "id": "IGF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P05019",
                "type": "external"
            }
        ],
        "mass": 21841.0,
        "length": 195,
        "protein_name": "Insulin-like growth factor 1",
        "gene_name": "IGF1",
        "organism": "Human",
        "refseq_name": "insulin-like growth factor 1 isoform 4 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_000609",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000609",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IGF1; IBP1; IGF-1",
        "gene_names_refseq": "IGF-I; IGF1; IGFI; IGF; MGF",
        "protein_names_uniprotkb": "Insulin-like growth factor 1; IGF-I; Insulin-like growth factor I; MGF; Mechano growth factor; Somatomedin-C",
        "protein_names_refseq": "insulin-like growth factor 1 (somatomedin C); insulin-like growth factor 1 isoform 4 preproprotein; insulin-like growth factor IB; mechano growth factor; somatomedin-C",
        "tax_id": 9606,
        "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); rheumatic heart disease (Disease Ontology:DOID:0050827); stroke (Disease Ontology:DOID:0051061); pycnodysostosis (Disease Ontology:DOID:0080038); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); PEHO syndrome (Disease Ontology:DOID:0080539); congenital disorder of glycosylation Ia (Disease Ontology:DOID:0080552); Graves ophthalmopathy (Disease Ontology:DOID:0081120); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); microcephaly (Disease Ontology:DOID:10907); IgA vasculitis (Disease Ontology:DOID:11123); osteoporosis (Disease Ontology:DOID:11476); polycystic ovary syndrome (Disease Ontology:DOID:11612); myopia (Disease Ontology:DOID:11830); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); granulomatosis with polyangiitis (Disease Ontology:DOID:12132); Graves' disease (Disease Ontology:DOID:12361); acoustic neuroma (Disease Ontology:DOID:12689); Huntington's disease (Disease Ontology:DOID:12858); dilated cardiomyopathy (Disease Ontology:DOID:12930); retinopathy of prematurity (Disease Ontology:DOID:13025); cholestasis (Disease Ontology:DOID:13580); folic acid deficiency anemia (Disease Ontology:DOID:14026); alcoholic neuropathy (Disease Ontology:DOID:14183); hypothyroidism (Disease Ontology:DOID:1459); cystic fibrosis (Disease Ontology:DOID:1485); depressive disorder (Disease Ontology:DOID:1596); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); transient cerebral ischemia (Disease Ontology:DOID:224); brain ischemia (Disease Ontology:DOID:2316); arteriosclerosis (Disease Ontology:DOID:2349); severe acute respiratory syndrome (Disease Ontology:DOID:2945); familial Mediterranean fever (Disease Ontology:DOID:2987); high grade glioma (Disease Ontology:DOID:3070); carotid artery disease (Disease Ontology:DOID:3407); Noonan syndrome (Disease Ontology:DOID:3490); Turner syndrome (Disease Ontology:DOID:3491); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); coronary stenosis (Disease Ontology:DOID:4248); borna disease (Disease Ontology:DOID:5154); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); uveal melanoma (Disease Ontology:DOID:6039); acne (Disease Ontology:DOID:6543); osteoarthritis (Disease Ontology:DOID:8398); lung disease (Disease Ontology:DOID:850); prostate carcinoma in situ (Disease Ontology:DOID:8634); vascular dementia (Disease Ontology:DOID:8725); psoriasis (Disease Ontology:DOID:8893); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); Laron syndrome (Disease Ontology:DOID:9521); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); alopecia (Disease Ontology:DOID:987); growth delay due to insulin-like growth factor type 1 deficiency (MONDO:MONDO:0012110)",
        "pathway": " (hsa:3479);  (R-HSA-114608);  (R-HSA-2404192);  (R-HSA-2428928);  (R-HSA-2428933);  (R-HSA-381426);  (R-HSA-422085)",
        "pathway_count": 7,
        "publication_count": 177,
        "publication_id_list": "10026136;10077652;10218588;10391209;10512690;10531310;10604470;10614670;10681634;10810289;10898936;10912521;10951195;10990447;11089560;11158056;11250653;11264294;11316748;11316783;11522292;11557037;11600536;11606061;11739083;11751371;11756331;11788658;12050285;12241545;12354137;12379487;12414809;12466191;12553549;12639902;12810533;12904166;1310594;1319992;1370451;1372070;1383255;1435334;14599721;14630798;14712218;15126567;15126574;15142980;15182363;15256494;15297306;15308688;15469690;15485880;15525596;15604212;15642270;16754202;1697749;16981855;17047378;17249697;17289852;17312271;17408801;17595255;17985932;18396350;18443287;1845984;19139090;19280057;19327128;19578119;19628676;2018498;2036417;2082190;20881139;21076856;22140443;22351760;22869377;23243309;23640497;23696648;24132240;24389050;2476804;2479552;25576301;25892735;26091039;26276395;26375851;27600516;27846572;27862975;28228285;2839228;29242379;2935423;2937782;29557506;2969892;29769354;29786170;29789417;3002851;3011795;3013881;3015966;3019338;30315122;30418433;30429286;31844290;32157095;32350084;3242681;33717175;3455760;35051231;35251023;35580925;35907924;36241641;36284347;37938771;38791310;38941670;38972889;39451175;6189745;632300;6358902;6382022;6457647;7493944;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7541045;7543116;7559478;7559507;7588299;7683646;7689487;7876259;8033892;8467233;8495408;8530377;8662806;8781553;8810325;8817670;8857020;8894645;8964575;9003010;9497324;9553137;9690470;9709957;9733769;9786878;9832424;9852124;9922210",
        "class_list": "",
        "function": "Analysis of VEGF, IGF1/2 and the Long Noncoding RNA (lncRNA) H19 Expression in Polish Women with Endometriosis. Publication Status: Online-Only, [RefSeq, PubMed]; Characterisation of IGF-1 (rs7136446) and IL-6 (rs1800795) polymorphisms among breast cancer patients in western Algeria., [RefSeq, PubMed]; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]-2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation (PubMed:21076856, PubMed:24132240). Ca(2+)-dependent exocytosis of IGF1 is required for sensory perception of smell in the olfactory bulb (By similarity). Acts as a ligand for IGF1R. Binds to the alpha subunit of IGF1R, leading to the activation of the intrinsic tyrosine kinase activity which autophosphorylates tyrosine residues in the beta subunit thus initiating a cascade of down-stream signaling events leading to activation of the PI3K-AKT/PKB and the Ras-MAPK pathways. Binds to integrins ITGAV:ITGB3 and ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and IGFR1 are essential for IGF1 signaling. Induces the phosphorylation and activation of IGFR1, MAPK3/ERK1, MAPK1/ERK2 and AKT1 (PubMed:19578119, PubMed:22351760, PubMed:23243309, PubMed:23696648). As part of the MAPK/ERK signaling pathway, acts as a negative regulator of apoptosis in cardiomyocytes via promotion of STUB1/CHIP-mediated ubiquitination and degradation of ICER-type isoforms of CREM (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; The protein encoded by this gene is similar to insulin in function and structure and is a member of a family of proteins involved in mediating growth and development. The encoded protein is processed from a precursor, bound by a specific receptor, and secreted. Defects in this gene are a cause of insulin-like growth factor I deficiency. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar processing to generate mature protein. [provided by RefSeq, Sep 2015]., [RefSeq]; The role and mechanism of action of miR-483-3p in mediating the effects of IGF-1 on human renal tubular epithelial cells induced by high glucose. Publication Status: Online-Only, [RefSeq, PubMed]; When IGF-1 Meets Metabolic Inflammation and Polycystic Ovary Syndrome. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 61,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RWM7;E9PD02;P01343;Q14620",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0005178 integrin binding;GO:0005159 insulin-like growth factor receptor binding;GO:0030295 protein kinase activator activity;GO:0005179 hormone activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0035867 alphav-beta3 integrin-IGF-1-IGF1R complex;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031093 platelet alpha granule lumen",
        "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0009441 glycolate metabolic process;GO:0014896 muscle hypertrophy;GO:0014904 myotube cell development;GO:0060283 negative regulation of oocyte development",
        "synthesized_glycan_count": 0,
        "hit_score": 17.8,
        "record_id": "P05019-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P35680-1",
        "uniprot_id": [
            {
                "id": "HNF1B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P35680",
                "type": "external"
            }
        ],
        "mass": 61324.0,
        "length": 557,
        "protein_name": "Hepatocyte nuclear factor 1-beta",
        "gene_name": "HNF1B",
        "organism": "Human",
        "refseq_name": "hepatocyte nuclear factor 1-beta isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000449",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000449",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HNF1B; TCF2",
        "gene_names_refseq": "ADTKD3; FJHN; HNF-1-beta; HNF-1B; HNF1B; HNF1beta; HNF2; HPC11; LF-B3; LFB3; MODY5; RCAD; T2D; TCF-2; TCF2; VHNF1",
        "protein_names_uniprotkb": "Hepatocyte nuclear factor 1-beta; HNF-1-beta; HNF-1B; Homeoprotein LFB3; TCF-2; Transcription factor 2; Variant hepatic nuclear factor 1; vHNF1",
        "protein_names_refseq": "HNF1 beta A; hepatocyte nuclear factor 1-beta isoform 1; hepatocyte nuclear factor 1-beta; homeoprotein LFB3; transcription factor 2, hepatic",
        "tax_id": 9606,
        "disease": "esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); renal cysts and diabetes syndrome (Disease Ontology:DOID:0111101); prostate cancer (Disease Ontology:DOID:10283); pancreas disease (Disease Ontology:DOID:26); renal cell carcinoma (Disease Ontology:DOID:4450); kidney disease (Disease Ontology:DOID:557); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:6928);  (R-HSA-210744);  (R-HSA-210747);  (R-HSA-9831926);  (R-HSA-9925561);  (R-HSA-9925563);  (R-HSA-9937080)",
        "pathway_count": 7,
        "publication_count": 32,
        "publication_id_list": "10484768;10672455;11237011;11845238;11918730;12161522;14583183;15001636;15068978;15181075;15930087;16249435;16297991;1677179;17923767;17924661;18264097;24204001;26876668;28063628;28832583;28904123;29242379;29437277;33537174;33717175;33749890;33912179;35051231;39408938;7900999;9398836",
        "class_list": "",
        "function": "Findings implicate HNF1beta as a regulator of pancreas organogenesis and differentiation. [REVIEW] Review article, [RefSeq, PubMed]; HNF1B Transcription Factor: Key Regulator in Renal Physiology and Pathogenesis. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the homeodomain-containing superfamily of transcription factors. The protein binds to DNA as either a homodimer, or a heterodimer with the related protein hepatocyte nuclear factor 1-alpha. The gene has been shown to function in nephron development, and regulates development of the embryonic pancreas. Mutations in this gene result in renal cysts and diabetes syndrome and noninsulin-dependent diabetes mellitus, and expression of this gene is altered in some types of cancer. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Sep 2009]., [RefSeq]; Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3' (PubMed:17924661, PubMed:7900999). Binds to the FPC element in the cAMP regulatory unit of the PLAU gene (By similarity). Transcriptional activity is increased by coactivator PCBD1 (PubMed:24204001)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Transcription factor that binds to the inverted palindrome 5'-GTTAATNATTAAC-3'. Binds to the FPC element in the cAMP regulatory unit of the PLAU gene. Transcriptional activity is increased by coactivator PCBD1., [UniProtKB, UniProtKB, UniProtKB]; We propose that HNF1beta overexpression in the ovarian cancer participates in the altered expression pattern, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DKM3;E0YMJ9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0048806 genitalia development;GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "P35680-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q3MIT2-1",
        "uniprot_id": [
            {
                "id": "PUS10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q3MIT2",
                "type": "external"
            }
        ],
        "mass": 60244.0,
        "length": 529,
        "protein_name": "tRNA pseudouridine synthase Pus10",
        "gene_name": "PUS10",
        "organism": "Human",
        "refseq_name": "tRNA pseudouridine synthase Pus10 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001309052",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309052",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PUS10; CCDC139; DOBI",
        "gene_names_refseq": "CCDC139; DOBI; Hup10; PUS10",
        "protein_names_uniprotkb": "tRNA pseudouridine synthase Pus10; 5.4.99.25; Coiled-coil domain-containing protein 139; Hup10; Psi55 synthase; tRNA pseudouridine 55 synthase; tRNA pseudouridylate synthase; tRNA-uridine isomerase",
        "protein_names_refseq": "coiled-coil domain containing 139; coiled-coil domain-containing protein 139; pseudouridylate synthase 10; psi55 synthase; putative tRNA pseudouridine synthase Pus10; tRNA pseudouridine 55 synthase; tRNA pseudouridine synthase Pus10 isoform 1; tRNA pseudouridylate synthase; tRNA-uridine isomerase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:150962)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "10.1038/emboj.2013.79;11237011;14527409;16959974;17525332;17900615;18077418;19068216;19240061;19712588;23186163;23481700;23584533;27846572;28832583;28981101;30530625;31819270;32157095;32357974;32938616;33023933;33298915;33537174;33912179;33968037;35051231",
        "class_list": "",
        "function": "Crystal structure of Pus10 (previously denoted as FLJ32312) at 2.0 A resolution and modeling studies describe protein domains and active sites, [RefSeq, PubMed]; Mammalian nuclear TRUB1, mitochondrial TRUB2, and cytoplasmic PUS10 produce conserved pseudouridine 55 in different sets of tRNA., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; PUS10 differentially participates in the metabolic pathways of miRNA and tRNA. In the nucleus, PUS10 promotes miRNA biogenesis via interaction with pri-miRNA.In the cytoplasm, PUS10 modifies tRNA, and its pseudouridylation activity is required for cell growth., [RefSeq, PubMed]; Protein with different functions depending on its subcellular location: involved in miRNA processing in the nucleus and acts as a tRNA pseudouridylate synthase in the cytoplasm (PubMed:31819270, PubMed:33023933). In the cytoplasm, acts as a pseudouridylate synthase by catalyzing synthesis of pseudouridine(54) and pseudouridine(55) from uracil-54 and uracil-55, respectively, in the psi GC loop of a subset of tRNAs (PubMed:30530625, PubMed:31819270, PubMed:33023933). tRNA pseudouridylate synthase activity is enhanced by the presence of 1-methyladenosine at position 53-61 of tRNAs (PubMed:30530625). Does not show tRNA pseudouridylate synthase activity in the nucleus (PubMed:33023933). In the nucleus, promotes primary microRNAs (pri-miRNAs) processing independently of its RNA pseudouridylate synthase activity (PubMed:31819270). Binds pri-miRNAs (PubMed:31819270). Modulator of TRAIL/TNFSF10-induced cell death via activation of procaspase-8 and BID cleavage (PubMed:14527409, PubMed:19712588). Required for the progression of the apoptotic signal through intrinsic mitochondrial cell death (PubMed:19712588)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Pseudouridination, the isomerization of uridine to pseudouridine, is the most common posttranscriptional nucleotide modification found in RNA and is essential for biologic functions such as spliceosome biogenesis. Pseudouridylate synthases, such as PUS10, catalyze pseudouridination of structural RNAs, including transfer, ribosomal, and splicing RNAs. These enzymes also act as RNA chaperones, facilitating the correct folding and assembly of tRNAs (McCleverty et al., 2007 [PubMed 17900615]).[supplied by OMIM, May 2009]., [RefSeq]; These data suggest that the cleaved DOBI may acquire a new function, possibly by cooperating with tBid in the mitochondrial event of cell death caused by TRAIL., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JPJ5;Q96MI8",
        "ec_number_list": [
            {
                "id": "5.4.99.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.25",
                "type": "external"
            },
            {
                "id": "5.4.99.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.99.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0009982 pseudouridine synthase activity;GO:0070878 primary miRNA binding;GO:0106029 tRNA pseudouridine synthase activity;GO:0160148 tRNA pseudouridine(55) synthase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0031119 tRNA pseudouridine synthesis;GO:0031053 primary miRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q3MIT2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96IP4-1",
        "uniprot_id": [
            {
                "id": "TET5A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96IP4",
                "type": "external"
            }
        ],
        "mass": 49666.0,
        "length": 442,
        "protein_name": "Terminal nucleotidyltransferase 5A",
        "gene_name": "TENT5A",
        "organism": "Human",
        "refseq_name": "terminal nucleotidyltransferase 5A",
        "refseq_ac": [
            {
                "id": "NP_060103",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060103",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TENT5A; C6orf37; FAM46A; XTP11",
        "gene_names_refseq": "C6orf37; FAM46A; OI18; TENT5A; XTP11",
        "protein_names_uniprotkb": "Terminal nucleotidyltransferase 5A; 2.7.7.19; HBV X-transactivated gene 11 protein; HBV XAg-transactivated protein 11",
        "protein_names_refseq": "HBV X-transactivated gene 11 protein; HBV XAg-transactivated protein 11; family with sequence similarity 46 member A; protein FAM46A; putative nucleotidyltransferase FAM46A; retinal expressed gene C6orf37; terminal nucleotidyltransferase 5A",
        "tax_id": 9606,
        "disease": "osteogenesis imperfecta type 18 (Disease Ontology:DOID:0111848); lung non-small cell carcinoma (Disease Ontology:DOID:3908); osteoarthritis (Disease Ontology:DOID:8398)",
        "pathway": " (hsa:55603)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "11237011;12054608;16545789;24715725;25576301;26992070;28228285;28446606;29242379;29331515;29358272;29557506;29632711;29769354;29786170;30484775;30779550;30833945;31844290;31848261;32157095;32161166;32387766;32488085;32897882;32938616;32983136;33141586;33370626;33392160;33592498;33882302;33968037;33981976;34087483;34171305;34185709;34509645;34932366;35051231;35137485;35318648;35580925;36010968;36241641;36284347;36581221;37141460;37938771",
        "class_list": "",
        "function": "A Genetic Variant of FAM46A is Associated With the Development of Adolescent Idiopathic Scoliosis in the Chinese Population., [RefSeq, PubMed]; A candidate of human retinal disease on chromosome 6, [RefSeq, PubMed]; A novel VNTR polymorphism in C6orf37 exists in Chinese population and is not associated with colorectal cancer risk GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Cytoplasmic non-canonical poly(A) RNA polymerase that catalyzes the transfer of one adenosine molecule from an ATP to an mRNA poly(A) tail bearing a 3'-OH terminal group and participates in the cytoplasmic polyadenylation (PubMed:33882302). Polyadenylates mRNA encoding extracellular matrix constituents and other genes crucial for bone mineralization and during osteoblast mineralization, mainly focuses on ER-targeted mRNAs (By similarity)., [UniProtKB, PubMed, UniProtKB]; FAM46A expression is elevated in glioblastoma and predicts poor prognosis of patients., [RefSeq, PubMed]; Tent5a modulates muscle fiber formation in adolescent idiopathic scoliosis via maintenance of myogenin expression., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7U4;Q5TF86;Q8NFZ9;Q9BW32;Q9NXV5",
        "ec_number_list": [
            {
                "id": "2.7.7.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.19",
                "type": "external"
            },
            {
                "id": "2.7.7.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.-",
                "type": "external"
            },
            {
                "id": "2.7.7.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.52",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:1990817 poly(A) RNA polymerase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0048255 mRNA stabilization;GO:0030501 positive regulation of bone mineralization;GO:0030278 regulation of ossification;GO:0045669 positive regulation of osteoblast differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q96IP4-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BY41-1",
        "uniprot_id": [
            {
                "id": "HDAC8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BY41",
                "type": "external"
            }
        ],
        "mass": 41758.0,
        "length": 377,
        "protein_name": "Histone deacetylase 8",
        "gene_name": "HDAC8",
        "organism": "Human",
        "refseq_name": "histone deacetylase 8 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001159890",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001159890",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HDAC8; CDA07; HDACL1",
        "gene_names_refseq": "CDA07; CDLS5; HD8; HDAC8; HDACL1; KDAC8; MRXS6; RPD3; WTS",
        "protein_names_uniprotkb": "Histone deacetylase 8; 3.5.1.-; 3.5.1.98; HD8; Protein deacetylase HDAC8; Protein decrotonylase HDAC8",
        "protein_names_refseq": "histone deacetylase 8 isoform 2; histone deacetylase-like 1; protein deacetylase HDAC8; protein decrotonylase HDAC8",
        "tax_id": 9606,
        "disease": "Wilson-Turner syndrome (Disease Ontology:DOID:0060814); Cornelia de Lange syndrome 5 (Disease Ontology:DOID:0080509); Hirschsprung's disease (Disease Ontology:DOID:10487); hypertension (Disease Ontology:DOID:10763); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); renovascular hypertension (Disease Ontology:DOID:1591); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); amphetamine abuse (Disease Ontology:DOID:670)",
        "pathway": " (hsa:55869);  (R-HSA-2122947);  (R-HSA-2644606);  (R-HSA-2894862);  (R-HSA-3214815);  (R-HSA-350054);  (R-HSA-9976102)",
        "pathway_count": 7,
        "publication_count": 119,
        "publication_id_list": "10206645;10444591;10449787;10713164;10748112;10756090;10879540;10882063;10904264;10922406;10922473;10926844;10964718;11006133;11044625;11112321;11237011;11461910;11509652;11533236;11585921;11739383;11740940;11742974;11909966;12032298;12050117;12209127;12354787;12374742;12391150;12509458;12530964;12724404;14701748;14980219;15107403;15242608;15477595;15546612;15574878;15760269;15772115;15824097;15829515;16093323;16256737;16530044;16530045;16538051;16738328;16751179;16809764;17003037;17114293;17157496;17211407;17401372;17646408;17646409;17721440;18043734;18077452;18094723;18296446;18374649;18824583;18824585;19053282;19151708;19524514;19726682;20972443;21587264;22885700;22889856;24171457;25880248;26101246;26992070;28228285;28497810;28510447;28832583;28834231;28904123;29242379;29493099;29716651;30429286;31844290;32157095;32488085;32938616;33298915;33592498;33912179;34932366;35580925;38182151;39043961;7513682;7566092;7588063;8001118;8649374;8687460;8889548;9150135;9244301;9315665;9462510;9604939;9620803;9651585;9651681;9694793;9790534;9819428",
        "class_list": "",
        "function": "Activation of HDAC8 Can Suppress the Proliferation of Osteosarcoma Cells via TP53 and STAT3/ERK Signaling Pathways., [RefSeq, PubMed]; Crystal structure, [RefSeq, PubMed]; Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4) (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748, PubMed:28497810). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748). Histone deacetylases act via the formation of large multiprotein complexes (PubMed:10748112, PubMed:10922473, PubMed:10926844, PubMed:14701748). Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin (PubMed:22885700). May play a role in smooth muscle cell contractility (PubMed:15772115). In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones (PubMed:28497810)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Histones play a critical role in transcriptional regulation, cell cycle progression, and developmental events. Histone acetylation/deacetylation alters chromosome structure and affects transcription factor access to DNA. The protein encoded by this gene belongs to class I of the histone deacetylase family. It catalyzes the deacetylation of lysine residues in the histone N-terminal tails and represses transcription in large multiprotein complexes with transcriptional co-repressors. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]., [RefSeq]; Reversible acetylation of HDAC8 regulates cell cycle., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6ND12;A6ND61;A6NET3;A6NJR3;A8MQ62;B4DKN0;B4DV22;Q86VC8;Q9NP76;Q9NYH4",
        "ec_number_list": [
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "3.5.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-",
                "type": "external"
            },
            {
                "id": "3.5.1.98",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98",
                "type": "external"
            },
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "2.1.1.364",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.57",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57",
                "type": "external"
            },
            {
                "id": "3.5.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.48",
                "type": "external"
            },
            {
                "id": "3.5.1.62",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.62",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0051879 Hsp90 protein binding;GO:0004407 histone deacetylase activity;GO:0030544 Hsp70 protein binding;GO:0033558 protein lysine deacetylase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000228 nuclear chromosome;GO:0000118 histone deacetylase complex",
        "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0031647 regulation of protein stability;GO:0006325 chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "Q9BY41-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P14902-1",
        "uniprot_id": [
            {
                "id": "I23O1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P14902",
                "type": "external"
            }
        ],
        "mass": 45326.0,
        "length": 403,
        "protein_name": "Indoleamine 2,3-dioxygenase 1",
        "gene_name": "IDO1",
        "organism": "Human",
        "refseq_name": "indoleamine 2,3-dioxygenase 1",
        "refseq_ac": [
            {
                "id": "NP_002155",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002155",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IDO1; IDO; INDO",
        "gene_names_refseq": "IDO-1; IDO1; IDO; INDO",
        "protein_names_uniprotkb": "Indoleamine 2,3-dioxygenase 1; 1.13.11.52; IDO-1; Indoleamine-pyrrole 2,3-dioxygenase",
        "protein_names_refseq": "indolamine 2,3 dioxygenase; indole 2,3-dioxygenase; indoleamine 2,3-dioxygenase 1; indoleamine-pyrrole 2,3-dioxygenase",
        "tax_id": 9606,
        "disease": "pre-eclampsia (Disease Ontology:DOID:10591); chlamydia (Disease Ontology:DOID:11263); dengue disease (Disease Ontology:DOID:12205); toxic shock syndrome (Disease Ontology:DOID:14115); pulmonary tuberculosis (Disease Ontology:DOID:2957); acquired immunodeficiency syndrome (Disease Ontology:DOID:635); eczema herpeticum (Disease Ontology:DOID:9123)",
        "pathway": " (hsa:3620);  (R-HSA-71240)",
        "pathway_count": 2,
        "publication_count": 69,
        "publication_id_list": "10049700;10391915;10672018;11237011;12007602;12140278;13069505;1449503;14502282;15364907;15880762;16376499;16477023;16574111;17671174;18026683;18056995;18262359;18418598;18620547;1907934;19338303;2109605;21097500;23103127;2326172;23478338;23783831;24029068;25157255;25313323;25394548;25691885;25950090;25970480;26155395;27862975;29057249;29093164;29242379;29557506;29786170;30484775;30833945;31844290;31848261;32157095;32488085;32938616;32983136;33968037;34171305;34185709;35051231;35318648;35580925;35874702;36284347;37938771;38064980;38369188;38382068;38635903;38848896;7514594;7883047;8294935;8666386;9180257",
        "class_list": "",
        "function": "CD58 Alterations Govern Antitumor Immune Responses by Inducing PDL1 and IDO in Diffuse Large B-Cell Lymphoma., [RefSeq, PubMed]; Catalyzes the first and rate limiting step of the catabolism of the essential amino acid tryptophan along the kynurenine pathway (PubMed:17671174, PubMed:18026683). Involved in the peripheral immune tolerance, contributing to maintain homeostasis by preventing autoimmunity or immunopathology that would result from uncontrolled and overreacting immune responses (PubMed:25691885). Tryptophan shortage inhibits T lymphocytes division and accumulation of tryptophan catabolites induces T-cell apoptosis and differentiation of regulatory T-cells (PubMed:25691885). Acts as a suppressor of anti-tumor immunity (PubMed:14502282, PubMed:23103127, PubMed:25157255, PubMed:25691885). Limits the growth of intracellular pathogens by depriving tryptophan (PubMed:25691885). Protects the fetus from maternal immune rejection (PubMed:25691885)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Catalyzes the first and rate limiting step of the catabolism of tryptophan along the kynurenine pathway. Involved in immune regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Expression and Prognostic Significance of LAG-3, TIGIT, VISTA, and IDO1 in Endometrial Serous Carcinoma., [RefSeq, PubMed]; Low indoleamine 2, 3 dioxygenase (IDO) activity is associated with psycho-obstetric risk., [RefSeq, PubMed]; PABPC1L Induces IDO1 to Promote Tryptophan Metabolism and Immune Suppression in Renal Cell Carcinoma., [RefSeq, PubMed]; Quantitative Multiplexed Analysis of Indoleamine 2,3-Dioxygenase (IDO) and Arginase-1 (ARG1) Expression and Myeloid Cell Infiltration in Colorectal Cancer., [RefSeq, PubMed]; This gene encodes indoleamine 2,3-dioxygenase (IDO) - a heme enzyme that catalyzes the first and rate-limiting step in tryptophan catabolism to N-formyl-kynurenine. This enzyme acts on multiple tryptophan substrates including D-tryptophan, L-tryptophan, 5-hydroxy-tryptophan, tryptamine, and serotonin. This enzyme is thought to play a role in a variety of pathophysiological processes such as antimicrobial and antitumor defense, neuropathology, immunoregulation, and antioxidant activity. Through its expression in dendritic cells, monocytes, and macrophages this enzyme modulates T-cell behavior by its peri-cellular catabolization of the essential amino acid tryptophan.[provided by RefSeq, Feb 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E5RGR8;F6M9T7;Q540B4",
        "ec_number_list": [
            {
                "id": "1.13.11.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.52",
                "type": "external"
            },
            {
                "id": "1.13.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.11",
                "type": "external"
            },
            {
                "id": "1.13.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0004833 L-tryptophan 2,3-dioxygenase activity;GO:0033754 indoleamine 2,3-dioxygenase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0030485 smooth muscle contractile fiber;GO:0032421 stereocilium bundle",
        "go_biological_process": "GO:0006569 L-tryptophan catabolic process;GO:0019441 L-tryptophan catabolic process to kynurenine;GO:0007565 female pregnancy;GO:0019805 quinolinate biosynthetic process;GO:0070234 positive regulation of T cell apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "P14902-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NHV4-1",
        "uniprot_id": [
            {
                "id": "NEDD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NHV4",
                "type": "external"
            }
        ],
        "mass": 71966.0,
        "length": 660,
        "protein_name": "Protein NEDD1",
        "gene_name": "NEDD1",
        "organism": "Human",
        "refseq_name": "protein NEDD1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001128647",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128647",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NEDD1",
        "gene_names_refseq": "GCP-WD; NEDD1; TUBGCP7",
        "protein_names_uniprotkb": "Protein NEDD1; NEDD-1; Neural precursor cell expressed developmentally down-regulated protein 1",
        "protein_names_refseq": "NEDD-1; neural precursor cell expressed developmentally down-regulated protein 1; neural precursor cell expressed, developmentally down-regulated 1; protein NEDD1 isoform a; protein NEDD1; tubulin gamma complex associated protein 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:121441);  (R-HSA-2565942);  (R-HSA-380259);  (R-HSA-380270);  (R-HSA-380284);  (R-HSA-380320);  (R-HSA-5620912);  (R-HSA-8854518)",
        "pathway_count": 8,
        "publication_count": 159,
        "publication_id_list": "10.1101/2023.09.13.557529;11076968;11237011;11956313;12207013;12221128;12364337;12852856;13678582;14580337;14654843;15498487;15705883;16357211;16462731;16890155;17574030;17646400;17719545;18037885;18378770;18452278;18477460;18521620;18566290;18615013;18669648;18691976;18694559;18801063;19004860;19007248;19029337;19081074;19413330;19415658;19509060;19651622;19664994;19664995;19690332;19691289;19940019;20068231;20230748;20308558;20399632;20558667;21273506;21347367;21422230;21548880;21565611;21620453;21690413;21725307;21792235;22094468;22179047;22365832;22433857;22595525;22641346;22653444;22818914;23141531;23141541;23186163;23253480;23348840;23400999;23481700;23530209;23747070;23769972;23789104;23921553;24053599;24089205;24231678;24469809;24715725;24982133;25047611;25313408;25532896;25576301;26154972;27137183;27846572;27920218;28228285;28446606;28832583;29237092;29242379;29393594;29493099;29508533;29557506;29632711;29786170;29789417;30315122;30379171;30410026;30429286;30524438;30626607;30779550;30833945;31028180;31154438;31492838;31844290;31848261;31937595;32157095;32161166;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33351100;33402344;33537174;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34357683;34509645;35051231;35132862;35138101;35318648;35513511;35561310;35580925;35705054;36010968;36241641;36284347;36318115;37938771;38665916;39531497;40307207;7769006;7790358;8838651",
        "class_list": "",
        "function": "Authors show here that the expression of a NEDD1 isoform mimicking phosphorylation by Aurora A is sufficient to restore microtubule nucleation in the midzone under conditions of Aurora A inhibition. Publication Status: Online-Only, [RefSeq, PubMed]; NEDD1-S411 phosphorylation plays a critical function in the coordination of microtubule nucleation during mitosis., [RefSeq, PubMed]; PLK4-phosphorylated NEDD1 facilitates cartwheel assembly and centriole biogenesis initiations., [RefSeq, PubMed]; Required for mitosis progression. Promotes the nucleation of microtubules from the spindle., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 28,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0AZN0;B4E145;G3V3F1;Q8NA30",
        "ec_number_list": [],
        "go_molecular_function": "GO:0043015 gamma-tubulin binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0045177 apical part of cell",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0051301 cell division;GO:0007020 microtubule nucleation",
        "synthesized_glycan_count": 0,
        "hit_score": 16.9,
        "record_id": "Q8NHV4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A8MTL9-1",
        "uniprot_id": [
            {
                "id": "HMSD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A8MTL9",
                "type": "external"
            }
        ],
        "mass": 15355.0,
        "length": 139,
        "protein_name": "Serpin-like protein HMSD",
        "gene_name": "HMSD",
        "organism": "Human",
        "refseq_name": "serpin-like protein HMSD",
        "refseq_ac": [
            {
                "id": "NP_001116838",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116838",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HMSD; C18orf53",
        "gene_names_refseq": "ACC-6; ACC6; C18orf53; HMSD; HSMD-v",
        "protein_names_uniprotkb": "Serpin-like protein HMSD; Minor histocompatibility protein HMSD; Minor histocompatibility serpin domain-containing protein",
        "protein_names_refseq": "minor histocompatibility protein HMSD; serpin-like protein HMSD",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284293)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "17409267;28904123;31844290;8889548",
        "class_list": "",
        "function": "Putative serine protease inhibitor., [UniProtKB]; This gene encodes a serpin-domain containing protein that may function as a serine protease inhibitor. This gene is primarily expressed in cells of myeloid lineage. A polymorphism in this gene may result in the expression a splice variant that encodes a minor histocompatibility antigen. [provided by RefSeq, Oct 2010]., [RefSeq]; This splice variant of HMSD is the precursor of the histocompatibility antigen ACC-6. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and its expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. However, associated with GVHD, a favorable graft-versus-leukemia (GVL) can be induced by donor-recipient disparities in mHags. ACC-6 is presented to the cell surface by MHC HLA-B*4403. This complex specifically elicits donor-cytotoxic T-lymphocyte (CTL) reactivity against hematologic malignancies after treatment by HLA-identical allogenic BMT. It induces cell recognition and lysis by CTL. Immunogenicity of most autosomal mHags results from single-nucleotide polymorphisms that cause amino-acid substitutions within epitopes, leading to the differential recognition of peptides between donor and recipient., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0002253 activation of immune response;GO:0032729 positive regulation of type II interferon production;GO:0019835 cytolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "A8MTL9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P05112-1",
        "uniprot_id": [
            {
                "id": "IL4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P05112",
                "type": "external"
            }
        ],
        "mass": 17492.0,
        "length": 153,
        "protein_name": "Interleukin-4",
        "gene_name": "IL4",
        "organism": "Human",
        "refseq_name": "interleukin-4 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_000580",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000580",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL4",
        "gene_names_refseq": "BCGF-1; BCGF1; BSF-1; BSF1; IL-4; IL4",
        "protein_names_uniprotkb": "Interleukin-4; B-cell stimulatory factor 1; BSF-1; Binetrakin; IL-4; Lymphocyte stimulatory factor 1; Pitrakinra",
        "protein_names_refseq": "B cell growth factor 1; B_cell stimulatory factor 1; binetrakin; interleukin-4 isoform 1 precursor; lymphocyte stimulatory factor 1; pitrakinra",
        "tax_id": 9606,
        "disease": "biliary tract benign neoplasm (Disease Ontology:DOID:0050625); alopecia universalis (Disease Ontology:DOID:0050634); stroke (Disease Ontology:DOID:0051061); primary cutaneous T-cell non-Hodgkin lymphoma (Disease Ontology:DOID:0060061); COVID-19 (Disease Ontology:DOID:0080600); polymyositis (Disease Ontology:DOID:0080745); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); pelvic inflammatory disease (Disease Ontology:DOID:1003); trypanosomiasis (Disease Ontology:DOID:10113); dermatomyositis (Disease Ontology:DOID:10223); Alzheimer's disease (Disease Ontology:DOID:10652); nephritis (Disease Ontology:DOID:10952); anogenital venereal wart (Disease Ontology:DOID:11168); nephrotic syndrome (Disease Ontology:DOID:1184); primary biliary cholangitis (Disease Ontology:DOID:12236); vitiligo (Disease Ontology:DOID:12306); Sjogren's syndrome (Disease Ontology:DOID:12894); carotid stenosis (Disease Ontology:DOID:13001); Behcet's disease (Disease Ontology:DOID:13241); temporal arteritis (Disease Ontology:DOID:13375); cholestasis (Disease Ontology:DOID:13580); hypothyroidism (Disease Ontology:DOID:1459); cystic echinococcosis (Disease Ontology:DOID:1495); cognitive disorder (Disease Ontology:DOID:1561); cystitis (Disease Ontology:DOID:1679); pancreatic cancer (Disease Ontology:DOID:1793); hepatitis C (Disease Ontology:DOID:1883); hepatitis B (Disease Ontology:DOID:2043); autoimmune hepatitis (Disease Ontology:DOID:2048); multiple sclerosis (Disease Ontology:DOID:2377); irritant dermatitis (Disease Ontology:DOID:2772); bronchiolitis obliterans (Disease Ontology:DOID:2799); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); middle cerebral artery infarction (Disease Ontology:DOID:3525); cerebral infarction (Disease Ontology:DOID:3526); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); pulmonary fibrosis (Disease Ontology:DOID:3770); systemic scleroderma (Disease Ontology:DOID:418); allergic rhinitis (Disease Ontology:DOID:4481); rhinitis (Disease Ontology:DOID:4483); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); autoimmune thyroiditis (Disease Ontology:DOID:7188); herpes zoster (Disease Ontology:DOID:8536); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); leishmaniasis (Disease Ontology:DOID:9065); acute myocardial infarction (Disease Ontology:DOID:9408); type 1 diabetes mellitus (Disease Ontology:DOID:9744); toxocariasis (Disease Ontology:DOID:9790)",
        "pathway": " (hsa:3565);  (R-HSA-6785807);  (R-HSA-9012546);  (R-HSA-9976102)",
        "pathway_count": 4,
        "publication_count": 121,
        "publication_id_list": "10023775;10023777;10219247;10369418;10510379;10586089;10867011;11058569;11084045;11104795;11120780;11278437;11278729;11356008;11404481;11463377;11526337;11960372;12223527;12242343;12600988;12832402;1400355;14634100;14681304;14712222;15116091;1511746;15261459;15584925;1567880;1567881;1569578;15805299;15869882;15950906;16007214;16048438;1609277;16107692;16205632;16236134;16397018;16451196;16510571;16540365;16606674;17427945;17458857;17572495;18243101;18353781;18447642;18644974;19124156;19185846;1932028;19397496;1946344;1993171;20493732;21102457;21252155;21689689;21730069;21937440;21994466;22046235;22205702;22383755;22693070;22851691;23086340;23124025;23172665;23455323;23555662;23967200;24097101;24213139;24743777;2521231;25234944;2535858;2971718;3016727;32222466;3257560;32576222;38725177;38959653;39080124;39242402;39405377;40930100;7510216;7512451;7529288;7664036;7721895;7795521;7796300;7806280;7898939;7907877;8085155;8151703;8602263;8621622;8663118;8668165;8797861;8816495;9013879;9325300;9651359;9723655;9736340;9792649;9822675;9874564",
        "class_list": "",
        "function": "A call for clinical trials in glioblastoma multiforme for interleukin 4, interleukin 6, interleukin 13 and CD40. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Association of NLRP3 and IL-4 VNTR polymorphisms and genetic susceptibility to preeclampsia: A case-control study., [RefSeq, PubMed]; Cytokine secreted primarily by mast cells, T-cells, eosinophils, and basophils that plays a role in regulating antibody production, hematopoiesis and inflammation, and the development of effector T-cell responses (PubMed:1993171, PubMed:3016727). Induces the expression of class II MHC molecules on resting B-cells. Enhances both secretion and cell surface expression of IgE and IgG1 (PubMed:1993171). Also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes (PubMed:2521231). Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4. In addition, plays a critical role in higher functions of the normal brain, such as memory and learning (By similarity). Upon binding to IL4, IL4R receptor dimerizes either with the common IL2R gamma chain/IL2RG to produce the type 1 signaling complex, located mainly on hematopoietic cells, or with the IL13RA1 to produce the type 2 complex, which is also expressed on nonhematopoietic cells (PubMed:10219247, PubMed:11526337, PubMed:18243101). Engagement of both types of receptors initiates JAK3 and to a lower extend JAK1 phosphorylation leading to activation of the signal transducer and activator of transcription 6/STAT6 (PubMed:7721895)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Increased level of GATA3-AS1 long non-coding RNA is correlated with the upregulation of GATA3 and IL-4 genes in multiple sclerosis patients. Publication Status: Online-Only, [RefSeq, PubMed]; Nasal mucosal fibroblasts produce IL-4 to induce Th2 response., [RefSeq, PubMed]; The aryl hydrocarbon receptor shapes monocyte transcriptional responses to interleukin-4 by prolonging STAT6 binding to promoters., [RefSeq, PubMed]; The protein encoded by this gene is a pleiotropic cytokine produced by activated T cells. This cytokine is a ligand for interleukin 4 receptor. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play a central role in mediating the immune regulatory signal of this cytokine. This gene, IL3, IL5, IL13, and CSF2 form a cytokine gene cluster on chromosome 5q, with this gene particularly close to IL13. This gene, IL13 and IL5 are found to be regulated coordinately by several long-range regulatory elements in an over 120 kilobase range on the chromosome. IL4 is considered an important cytokine for tissue repair, counterbalancing the effects of proinflammatory type 1 cytokines, however, it also promotes allergic airway inflammation. Moreover, IL-4, a type 2 cytokine, mediates and regulates a variety of human host responses such as allergic, anti-parasitic, wound healing, and acute inflammation. This cytokine has been reported to promote resolution of neutrophil-mediated acute lung injury. In an allergic response, IL-4 has an essential role in the production of allergen-specific immunoglobin (Ig) E. This pro-inflammatory cytokine has been observed to be increased in COVID-19 (Coronavirus disease 2019) patients, but is not necessarily associated with severe COVID-19 pathology. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported. [provided by RefSeq, Aug 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "monitoring",
        "glycan_count": 1,
        "disease_count": 50,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14630;Q6NZ77",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005125 cytokine activity;GO:0008083 growth factor activity;GO:0005136 interleukin-4 receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:1903845 negative regulation of cellular response to transforming growth factor beta stimulus;GO:0010633 negative regulation of epithelial cell migration;GO:0032736 positive regulation of interleukin-13 production;GO:0035771 interleukin-4-mediated signaling pathway;GO:2001171 positive regulation of ATP biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.5,
        "record_id": "P05112-1",
        "record_type": "protein",
        "filter_code": "0100000.1100111.100000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P05187-1",
        "uniprot_id": [
            {
                "id": "PPB1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P05187",
                "type": "external"
            }
        ],
        "mass": 57954.0,
        "length": 535,
        "protein_name": "Alkaline phosphatase, placental type",
        "gene_name": "ALPP",
        "organism": "Human",
        "refseq_name": "alkaline phosphatase, placental type preproprotein",
        "refseq_ac": [
            {
                "id": "NP_001623",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001623",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ALPP; PLAP",
        "gene_names_refseq": "ALPP; ALP; PALP; PLAP-1; PLAP",
        "protein_names_uniprotkb": "Alkaline phosphatase, placental type; 3.1.3.1; Alkaline phosphatase Regan isozyme; PLAP-1; Placental alkaline phosphatase 1",
        "protein_names_refseq": "alkaline phosphatase Regan isozyme; alkaline phosphatase, placental type preproprotein; alkaline phosphatase, placental type; alkaline phosphomonoesterase; glycerophosphatase; placental alkaline phosphatase 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:250);  (R-HSA-6811438)",
        "pathway_count": 2,
        "publication_count": 78,
        "publication_id_list": "10.1101/2023.09.13.557529;10189370;10652308;10652516;11124260;11718716;11748249;11937510;12011112;12383348;12429822;15504911;15718469;15728195;15758030;15946677;16815919;17274799;1730777;18086915;18256213;18451304;18669648;19164740;1939159;19536132;19715559;20058876;20068231;20112406;20163571;20663553;20693656;20874812;2153284;21807881;22013193;22188167;23091056;23239882;23378023;23462996;23839779;23936529;23940353;24019514;24119662;25576301;25708460;25775211;27862975;29393594;3001717;3042787;30484775;32387766;33968037;3422741;3459156;3461452;34932366;35051231;3512548;35580925;36215666;36241641;36763725;37951846;37952310;6651840;8636227;8945478;9244307;9476900;9510256;9653114;9707577;9915833",
        "class_list": "",
        "function": "Alkaline Phosphatase is an Independent Risk Factor for Periprosthetic Fractures in Total Joint Arthroplasty. Publication Status: Online-Only, [RefSeq, PubMed]; Alkaline phosphatase that can hydrolyze various phosphate compounds., [UniProtKB, PubMed, PubMed]; Data indicate that p180 is required for the efficient targeting of placental alkaline phosphatase (ALPP) mRNA to the endoplasmic reticulum (ER)., [RefSeq, PubMed]; Differential expression of Pl(1) and Pl(2) probably results from linkage disequilibrium with the sequence variation rs2014683G>A in the ALPP gene promoter that was shown to have allele-specific binding patterns to placental nuclear proteins., [RefSeq, PubMed]; Role of serum alkaline phosphatase as a potential biomarker of severity and prognosis in intracerebral hemorrhage., [RefSeq, PubMed]; Structure of placental alkaline phosphatase with pNPP contained only p-nitrophenol in three distinct sites, while the structure with 5'-AMP contained the p-nitrophenyl group in two of the sites instead of 5'-AMP, [RefSeq, PubMed]; The protein encoded by this gene is an alkaline phosphatase, a metalloenzyme that catalyzes the hydrolysis of phosphoric acid monoesters. It belongs to a multigene family composed of four alkaline phosphatase isoenzymes. The enzyme functions as a homodimer and has a catalytic site containing one magnesium and two zinc ions, which are required for its enzymatic function. One of the main sources of this enzyme is the liver, and thus, it's one of several indicators of liver injury in different clinical conditions. In pregnant women, this protein is primarily expressed in placental and endometrial tissue, however, strong ectopic expression has been detected in ovarian adenocarcinoma, serous cystadenocarcinoma, and other ovarian cancer cells. [provided by RefSeq, Aug 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P05188;P06861;Q53S78;Q96DB7",
        "ec_number_list": [
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004035 alkaline phosphatase activity;GO:0000287 magnesium ion binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0098552 side of membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "P05187-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100010000001.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60671-1",
        "uniprot_id": [
            {
                "id": "RAD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60671",
                "type": "external"
            }
        ],
        "mass": 31827.0,
        "length": 282,
        "protein_name": "Cell cycle checkpoint protein RAD1",
        "gene_name": "RAD1",
        "organism": "Human",
        "refseq_name": "cell cycle checkpoint protein RAD1",
        "refseq_ac": [
            {
                "id": "NP_002844",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002844",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAD1; REC1",
        "gene_names_refseq": "HRAD1; RAD1; REC1",
        "protein_names_uniprotkb": "Cell cycle checkpoint protein RAD1; Rad1-like DNA damage checkpoint protein; hRAD1",
        "protein_names_refseq": "DNA repair exonuclease REC1; DNA repair exonuclease rad1 homolog; RAD1 checkpoint clamp component; RAD1 homolog; cell cycle checkpoint protein Hrad1; cell cycle checkpoint protein RAD1; checkpoint control protein HRAD1; exonuclease homolog RAD1; rad1-like DNA damage checkpoint protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5810);  (R-HSA-176187);  (R-HSA-5685938);  (R-HSA-5693607);  (R-HSA-5693616);  (R-HSA-6804756);  (R-HSA-69473);  (R-HSA-9709570)",
        "pathway_count": 8,
        "publication_count": 233,
        "publication_id_list": "10.1101/2023.09.13.557529;10051570;10212258;10359610;10373362;10373512;10435622;10438626;10500146;10551859;10570149;10570174;10604467;10673500;10673501;10710310;10733923;10744977;10777662;10827953;10846170;10859164;10884347;10884395;10921897;11080452;11139606;11237011;11239457;11301010;11376695;11390642;11447225;11511362;11546806;11551930;11571269;11573955;11698410;11740489;11751635;11780126;11832208;11944979;12064478;12139939;12152085;12191481;12226092;12228710;12370410;12379650;12393879;12399544;12545175;12578958;12676583;12676925;12702766;12750383;12759351;12791985;12851404;12914926;12963847;14500360;14576433;14603323;14605214;14611806;14624239;14702041;14734547;15053879;15189136;15190204;15226314;15314187;15359272;15485900;15556996;15665856;15703751;15707391;15743907;15833913;15866171;15871698;15897895;16148040;16153896;16216273;16322561;16327781;16360315;16407120;16530042;16885023;17108107;17349958;17515903;17575048;17591690;17928296;17962301;17965729;18171670;18317453;18480045;18490454;18539610;18541667;18757400;18805091;18923075;18971343;19121998;19357644;19419957;19965871;20112406;20154705;20233725;20729832;20729858;20729859;20959462;20965415;21052091;21240188;21263215;21317932;21325134;21335604;21565612;21659603;21680713;21777809;21804533;22021381;22024395;22194698;22231403;22635276;22661229;22661230;22792074;22977173;23000554;23149936;23345434;23468639;23481700;23485397;23676219;23810717;24013206;24145406;24715725;24874608;25113031;25122754;25418920;25558984;25576301;25659039;26145171;26154972;26375851;26992070;27058226;27846572;27920218;28063628;28218747;28832583;28904123;29242379;29331515;29393594;29437277;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30429286;30484775;30524438;30779550;31154438;31776186;31844290;31937595;32157095;32161166;32265295;32387766;32488085;32938616;32983136;33141586;33298915;33392160;33936100;33968037;33978741;34211107;34440403;34509645;35051231;35561310;36010968;36172813;36215666;36241641;36841485;8196638;8702565;8943031;9278511;9278512;9660799;9705271;9705507;9716408;9828137;9828139;9837724;9878245;9925639",
        "class_list": "",
        "function": "Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10846170, PubMed:10884395). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:12578958). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:15871698). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:15314187, PubMed:15556996, PubMed:15871698). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a component of a heterotrimeric cell cycle checkpoint complex, known as the 9-1-1 complex, that is activated to stop cell cycle progression in response to DNA damage or incomplete DNA replication. The 9-1-1 complex is recruited by RAD17 to affected sites where it may attract specialized DNA polymerases and other DNA repair effectors. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jan 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 9792,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75572;O95304;Q1W161;Q5KSM0;Q5KSM1;Q9UEP1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003684 damaged DNA binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005694 chromosome;GO:0030896 checkpoint clamp complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0051598 meiotic recombination checkpoint signaling;GO:0006281 DNA repair;GO:0021762 substantia nigra development;GO:0006974 DNA damage response;GO:0071479 cellular response to ionizing radiation",
        "synthesized_glycan_count": 0,
        "hit_score": 23.8,
        "record_id": "O60671-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75832-1",
        "uniprot_id": [
            {
                "id": "PSD10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75832",
                "type": "external"
            }
        ],
        "mass": 24428.0,
        "length": 226,
        "protein_name": "26S proteasome non-ATPase regulatory subunit 10",
        "gene_name": "PSMD10",
        "organism": "Human",
        "refseq_name": "26S proteasome non-ATPase regulatory subunit 10 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_002805",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002805",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSMD10",
        "gene_names_refseq": "PSMD10; dJ889N15.2; p28(GANK); p28",
        "protein_names_uniprotkb": "26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; Gankyrin; p28(GANK)",
        "protein_names_refseq": "26S proteasome non-ATPase regulatory subunit 10 isoform 1; 26S proteasome non-ATPase regulatory subunit 10; 26S proteasome regulatory subunit p28; ankyrin repeat protein; gankyrin; hepatocellular carcinoma-associated protein p28-II; proteasome (prosome, macropain) 26S subunit, non-ATPase, 10",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5716);  (R-HSA-9907900)",
        "pathway_count": 2,
        "publication_count": 55,
        "publication_id_list": "10613832;10973495;11237011;11779854;11900540;14573599;14997555;15379554;15831487;16023600;16251969;16990800;17189198;17323924;17540904;17948026;18040287;19413330;19490896;19729910;20068231;20471946;20628200;22574218;23301498;28228285;28263418;28442575;28598414;28832583;28904123;29242379;29393594;30833945;31222486;31844290;32161166;32350084;32938616;32983136;33592498;33968037;34171305;34229054;34357683;34932366;35051231;35154160;35561310;35580925;36028821;36121635;36241641;36776524;9714768",
        "class_list": "",
        "function": "Acts as a chaperone during the assembly of the 26S proteasome, specifically of the PA700/19S regulatory complex (RC). In the initial step of the base subcomplex assembly is part of an intermediate PSMD10:PSMC4:PSMC5:PAAF1 module which probably assembles with a PSMD5:PSMC2:PSMC1:PSMD2 module. Independently of the proteasome, regulates EGF-induced AKT activation through inhibition of the RHOA/ROCK/PTEN pathway, leading to prolonged AKT activation. Plays an important role in RAS-induced tumorigenesis., [UniProtKB]; Acts as an proto-oncoprotein by being involved in negative regulation of tumor suppressors RB1 and p53/TP53. Overexpression is leading to phosphorylation of RB1 and proteasomal degradation of RB1. Regulates CDK4-mediated phosphorylation of RB1 by competing with CDKN2A for binding with CDK4. Facilitates binding of MDM2 to p53/TP53 and the mono- and polyubiquitination of p53/TP53 by MDM2 suggesting a function in targeting the TP53:MDM2 complex to the 26S proteasome. Involved in p53-independent apoptosis. Involved in regulation of NF-kappa-B by retaining it in the cytoplasm. Binds to the NF-kappa-B component RELA and accelerates its XPO1/CRM1-mediated nuclear export., [UniProtKB]; Gankyrin interactions with partner proteins are mediated by residues situated on its concave surface, [RefSeq, PubMed]; Gankyrin-mediated interaction between cancer cells and tumor-associated macrophages facilitates prostate cancer progression and androgen deprivation therapy resistance. Publication Status: Online-Only, [RefSeq, PubMed]; Hsa-miR-1248 suppressed the proliferation, invasion and migration of colorectal cancer cells via inhibiting PSMD10. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-188-5p and Host MALAT1 Regulate RBE Cell Migration, Invasion, and Apoptosis via Up-regulating PSMD10 in Cholangiocarcinoma., [RefSeq, PubMed]; This gene encodes a subunit of the PA700/19S complex, which is the regulatory component of the 26S proteasome. The 26S proteosome complex is required for ubiquitin-dependent protein degradation. This protein is a non-ATPase subunit that may be involved in protein-protein interactions. Aberrant expression of this gene may paly a role in tumorigenesis. Two transcripts encoding different isoforms have been described. Pseudogenes have been identified on chromosomes 3 and 20.[provided by RefSeq, Mar 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5U0B2;Q8IZK9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0000502 proteasome complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030307 positive regulation of cell growth;GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "O75832-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7L0Q8-1",
        "uniprot_id": [
            {
                "id": "RHOU_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7L0Q8",
                "type": "external"
            }
        ],
        "mass": 28218.0,
        "length": 258,
        "protein_name": "Rho-related GTP-binding protein RhoU",
        "gene_name": "RHOU",
        "organism": "Human",
        "refseq_name": "rho-related GTP-binding protein RhoU",
        "refseq_ac": [
            {
                "id": "NP_067028",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_067028",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RHOU; ARHU; CDC42L1; G28K; SB128; WRCH1",
        "gene_names_refseq": "ARHU; CDC42L1; G28K; RHOU; WRCH1; hG28K",
        "protein_names_uniprotkb": "Rho-related GTP-binding protein RhoU; 3.6.5.2; CDC42-like GTPase 1; GTP-binding protein-like 1; Rho GTPase-like protein ARHU; Ryu GTPase; WRCH-1; Wnt-1 responsive Cdc42 homolog 1",
        "protein_names_refseq": "2310026M05Rik; CDC42-like GTPase 1; GTP-binding protein SB128; GTP-binding protein like 1; Ryu GTPase; ras homolog gene family, member U; ras-like gene family member U; rho GTPase-like protein ARHU; rho-related GTP-binding protein RhoU; wnt-1 responsive Cdc42 homolog 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:58480);  (R-HSA-6785807);  (R-HSA-9013420)",
        "pathway_count": 3,
        "publication_count": 120,
        "publication_id_list": "10023775;10219247;10369418;10510379;10586089;10867011;11058569;11084045;11104795;11120780;11278437;11278729;11356008;11404481;11459829;11463377;11894124;11960372;12223527;12242343;12600988;12832402;14634100;14712222;14731133;15116091;15261459;15350535;15556869;15584925;15805299;15869882;15950906;16007214;16046391;16048438;16107692;16205632;16236134;16397018;16451196;16472646;16510571;16540365;16606674;16751668;17427945;17458857;17504809;17572495;17620058;18086875;18243101;18353781;18447642;18644974;19064640;19124156;19185846;19397496;20493732;20547754;21102457;21252155;21508312;21565175;21689689;21730069;21834987;21937440;21994466;22046235;22205702;22383755;22693070;22851691;23086340;23124025;23172665;23455323;23555662;23967200;24097101;24743777;25234944;26598620;30410026;30484775;31601299;31848261;31871319;32139877;32157095;32737221;32983136;33592498;35580925;36221055;38180080;38566133;7510216;7512451;7529288;7795521;7796300;7898939;7907877;8085155;8602263;8621622;8663118;8668165;8797861;8816495;9013879;9651359;9723655;9736340;9822675;9874564",
        "class_list": "",
        "function": "Binds to and activates protein kinase PAK1 (PubMed:11459829). Plays a role in the regulation of cell morphology, cytoskeletal organization and focal adhesion assembly during cell migration (PubMed:11459829, PubMed:17620058, PubMed:18086875, PubMed:21834987). Also stimulates quiescent cells to reenter the cell cycle (PubMed:11459829). Has no detectable GTPase activity but its high intrinsic guanine nucleotide exchange activity suggests it is constitutively GTP-bound (PubMed:16472646)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Down regulation of WRCH1 by estradiol in breast cancer and altered expression of WRCH1 is associated with other cancers, [RefSeq, PubMed]; G28K cDNA encodes a protein of 258 amino acids with homology to the cell division cycle 42/G25K protein; this gene is located at 1q42.11-q42.3; G28K was abundantly expressed in the stomach and the small intestine, [RefSeq, PubMed]; Lipogenic signalling modulates prostate cancer cell adhesion and migration via modification of Rho GTPases., [RefSeq, PubMed]; LncRNA SNHG16 promotes development of oesophageal squamous cell carcinoma by interacting with EIF4A3 and modulating RhoU mRNA stability. Publication Status: Online-Only, [RefSeq, PubMed]; RhoU forms homo-oligomers to regulate cellular responses., [RefSeq, PubMed]; SUMOylation of annexin A6 retards cell migration and tumor growth by suppressing RHOU/AKT1-involved EMT in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; These results indicate CDK6 and RHOU play important roles in the invasiveness of NF-PAs, and the established diagnostic method is valuable for directing the clinical screening and postoperative treatment., [RefSeq, PubMed]; This gene encodes a member of the Rho family of GTPases. This protein can activate PAK1 and JNK1, and can induce filopodium formation and stress fiber dissolution. It may also mediate the effects of WNT1 signaling in the regulation of cell morphology, cytoskeletal organization, and cell proliferation. A non-coding transcript variant of this gene results from naturally occurring read-through transcription between this locus and the neighboring DUSP5P (dual specificity phosphatase 5 pseudogene) locus.[provided by RefSeq, Mar 2011]., [RefSeq]",
        "predicted_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "B1AKN1;Q59FE9;Q8TDQ2",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "1.14.13.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.13.39",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0002102 podosome",
        "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007165 signal transduction;GO:0051056 regulation of small GTPase mediated signal transduction;GO:1903955 positive regulation of protein targeting to mitochondrion",
        "synthesized_glycan_count": 0,
        "hit_score": 12.1,
        "record_id": "Q7L0Q8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NWF9-2",
        "uniprot_id": [
            {
                "id": "RN216_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NWF9",
                "type": "external"
            }
        ],
        "mass": 99406.0,
        "length": 866,
        "protein_name": "E3 ubiquitin-protein ligase RNF216",
        "gene_name": "RNF216",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase RNF216 isoform a",
        "refseq_ac": [
            {
                "id": "NP_996994",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_996994",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RNF216; TRIAD3; UBCE7IP1; ZIN",
        "gene_names_refseq": "CAHH; RNF216; TRIAD3; U7I1; UBCE7IP1; ZIN",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RNF216; 2.3.2.27; RING finger protein 216; RING-type E3 ubiquitin transferase RNF216; Triad domain-containing protein 3; Ubiquitin-conjugating enzyme 7-interacting protein 1; Zinc finger protein inhibiting NF-kappa-B",
        "protein_names_refseq": "E3 ubiquitin-protein ligase RNF216 isoform a; E3 ubiquitin-protein ligase RNF216; RING-type E3 ubiquitin transferase RNF216; triad domain-containing protein 3; ubiquitin-conjugating enzyme 7-interacting protein 1; zinc finger protein inhibiting NF-kappa-B",
        "tax_id": 9606,
        "disease": "Gordon Holmes syndrome (Disease Ontology:DOID:0111587)",
        "pathway": " (hsa:54476);  (R-HSA-936440)",
        "pathway_count": 2,
        "publication_count": 94,
        "publication_id_list": "11854271;15107846;15367624;16699525;16715065;17924679;17991829;18057259;18200010;19125153;19664994;19881509;19893624;20304918;20434986;22645359;23186163;23481700;23656588;24397554;24714562;24715725;24945773;25218447;25418920;25484083;25576301;25645385;25755297;25772364;25880248;25892735;26154972;26375851;26728094;26811146;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29769354;30315122;30429286;31154438;31217245;31844290;31848261;31937595;32157095;32265295;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33392160;33592498;33717175;33912179;33936100;33968037;33981976;34171305;34211107;34509645;34932366;34998453;35051231;35088240;35580925;36010968;36215666;36241641;36284347;36631489;37439148;38050071;38853469",
        "class_list": "",
        "function": "Clinical and genetic spectrum of RNF216-related disorder: a new case and literature review. Review article Publication Status: Online-Only, [RefSeq, PubMed]; E3 ubiquitin ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and then transfers it to substrates promoting their ubiquitination (PubMed:34998453). Plays a role in the regulation of antiviral responses by promoting the degradation of TRAF3, TLR4 and TLR9 (PubMed:15107846, PubMed:19893624). In turn, down-regulates NF-kappa-B and IRF3 activation as well as beta interferon production. Also participates in the regulation of autophagy by ubiquitinating BECN1 leading to its degradation and autophagy inhibition (PubMed:25484083). Plays a role in ARC-dependent synaptic plasticity by mediating ARC ubiquitination resulting in its rapid proteasomal degradation (PubMed:24945773). Plays aso an essential role in spermatogenesis and male fertility (By similarity). Mechanistically, regulates meiosis by promoting the degradation of PRKACB through the ubiquitin-mediated lysosome pathway (By similarity). Modulates the gonadotropin-releasing hormone signal pathway by affecting the stability of STAU2 that is required for the microtubule-dependent transport of neuronal RNA from the cell body to the dendrite (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Inhibits TNF and IL-1 mediated activation of NF-kappa-B. Promotes TNF and RIP mediated apoptosis., [UniProtKB, PubMed]; Interacts with RIP and inhibits tnf and il1-induced NFKB activation, [RefSeq, PubMed]; RNF216 affects the stability of STAU2 in the hypothalamus., [RefSeq, PubMed]; Ring finger protein 216 loss-of-function induces white matter hyperintensities by inhibiting oligodendroglia proliferation., [RefSeq, PubMed]; Structural basis of K63-ubiquitin chain formation by the Gordon-Holmes syndrome RBR E3 ubiquitin ligase RNF216., [RefSeq, PubMed]; This gene encodes a cytoplasmic protein which specifically colocalizes and interacts with the serine/threonine protein kinase, receptor-interacting protein (RIP). Zinc finger domains of the encoded protein are required for its interaction with RIP and for inhibition of TNF- and IL1-induced NF-kappa B activation pathways. The encoded protein may also function as an E3 ubiquitin-protein ligase which accepts ubiquitin from E2 ubiquitin-conjugating enzymes and transfers it to substrates. Several alternatively spliced transcript variants have been described for this locus but the full-length natures of only some are known. [provided by RefSeq, Jul 2008]., [RefSeq]; Whole-Exome Sequencing Identified a Novel Mutation in RNF216 in a Family with Gordon Holmes Syndrome., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "Q6Y691;Q75ML7;Q7Z2H7;Q7Z7C1;Q8NHW7;Q9NYT1",
        "ec_number_list": [
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "6.3.2.n3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.3.2.n3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0030136 clathrin-coated vesicle",
        "go_biological_process": "GO:0050691 regulation of defense response to virus by host;GO:0032648 regulation of interferon-beta production;GO:0006915 apoptotic process;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q9NWF9-2",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13404-4",
        "uniprot_id": [
            {
                "id": "UB2V1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13404",
                "type": "external"
            }
        ],
        "mass": 16495.0,
        "length": 147,
        "protein_name": "Ubiquitin-conjugating enzyme E2 variant 1",
        "gene_name": "UBE2V1",
        "organism": "Human",
        "refseq_name": "ubiquitin-conjugating enzyme E2 variant 1 isoform d",
        "refseq_ac": [
            {
                "id": "NP_001027459",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027459",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UBE2V1; CROC1; OKcl.19; UBE2V; UEV1",
        "gene_names_refseq": "CIR1; CROC-1; CROC1; UBE2V1; UBE2V; UEV-1; UEV1A; UEV1",
        "protein_names_uniprotkb": "Ubiquitin-conjugating enzyme E2 variant 1; CROC-1; TRAF6-regulated IKK activator 1 beta Uev1A; UEV-1",
        "protein_names_refseq": "DNA-binding protein; TRAF6-regulated IKK activator 1 beta Uev1A; ubiquitin-conjugating enzyme E2 variant 1 isoform d",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:387522);  (hsa:7335);  (R-HSA-168638);  (R-HSA-168927);  (R-HSA-202424);  (R-HSA-2871837);  (R-HSA-445989);  (R-HSA-450302);  (R-HSA-450321);  (R-HSA-5205685);  (R-HSA-5607764);  (R-HSA-9020702);  (R-HSA-937039);  (R-HSA-937041);  (R-HSA-9646399);  (R-HSA-9705671);  (R-HSA-975110);  (R-HSA-975144);  (R-HSA-983168)",
        "pathway_count": 19,
        "publication_count": 300,
        "publication_id_list": "10075690;10089880;10187770;10224040;10329646;10491388;10514433;10698680;10702308;10716940;10723127;10779524;10838074;10854325;10882101;10918611;11053425;11057907;11062501;11073981;11076860;11087742;11090634;11094434;11262391;11325957;11350924;11358993;11460167;11606584;11772397;11884229;11960013;12019269;12024216;12171911;12473183;12473184;12496252;12514169;12527755;12538665;12646216;12660731;12692549;12759408;12791687;12791997;12796777;12860405;12917691;14514672;14625308;14633987;14675537;14734113;15064760;15105418;15122200;15125833;15145317;15208624;15224091;15224092;15327770;15361868;15371334;15492225;15541657;15571818;15620648;15767370;15814722;15837794;15845454;15917247;16056267;16115877;16186825;16252004;16307917;16341139;16356853;16356855;16356856;16547522;16595681;16603398;16612002;16831874;16849449;16884718;16893187;16954532;16978534;17047224;17072321;17135271;17141195;17158449;17303577;17363905;17428801;17468049;17496917;17507369;17548359;17562858;17675297;17728323;17785525;17846173;17890055;17948050;17997719;18070982;18079694;18180283;1828071;1833184;18347055;18438411;18462684;18491316;18662542;18710948;18724939;18772140;19022706;19028597;19264966;19352404;19359218;19432818;19452197;19489725;19535145;19825828;19851334;19874575;19903815;19934406;19940261;20038579;20061386;20126261;20193029;20300203;20538596;20685844;20712405;21115803;21194381;2139180;2147937;21512573;21525931;21617041;21931591;21966355;22069318;22265677;22496338;2261476;22798961;22941947;23301498;23515720;24074955;24200693;24660806;24751536;24784582;25474007;25502872;25527497;25802875;26116755;26365381;27035970;27247382;27466718;27701768;27920218;28510447;28832583;29242379;29314611;29393594;29394115;2946959;29557506;29786170;29995846;31006531;31154438;31217245;31844290;31850239;32157095;32296703;32353859;32357974;32428392;32589897;32726803;32728199;32938616;32953130;32979938;33024073;33060197;33097660;33110251;33349665;33360543;33372174;33372854;33396605;33440148;33479219;33495715;33514628;33567255;33592498;33691108;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33936100;33963333;33968037;33989516;33990585;34019948;34021074;34054808;34084167;34110168;34166398;34239064;34290717;34341353;34375313;34400613;34439781;34452305;34471099;34502139;34503444;34597346;34725712;34921695;35102342;35251023;35643212;36580660;37051252;37786443;38287189;38665916;38795139;7479848;7499357;7612269;7628694;8327496;8332913;8533096;8550590;8599092;8601309;8622669;8837778;8972730;9252186;9305758;9346484;9362451;9371760;9380723;9418904;9430229;9430721;9580084;9668046;9687533;9705497;9744859;9768359;9859996;9864362;9865693;9990852;9990853",
        "class_list": "",
        "function": "Has no ubiquitin ligase activity on its own. The UBE2V1-UBE2N heterodimer catalyzes the synthesis of non-canonical poly-ubiquitin chains that are linked through Lys-63. This type of poly-ubiquitination activates IKK and does not seem to involve protein degradation by the proteasome. Plays a role in the activation of NF-kappa-B mediated by IL1B, TNF, TRAF6 and TRAF2. Mediates transcriptional activation of target genes. Plays a role in the control of progress through the cell cycle and differentiation. Plays a role in the error-free DNA repair pathway and contributes to the survival of cells after DNA damage. Promotes TRIM5 capsid-specific restriction activity and the UBE2V1-UBE2N heterodimer acts in concert with TRIM5 to generate 'Lys-63'-linked polyubiquitin chains which activate the MAP3K7/TAK1 complex which in turn results in the induction and expression of NF-kappa-B and MAPK-responsive inflammatory genes. Together with RNF135 and UBE2N, catalyzes the viral RNA-dependent 'Lys-63'-linked polyubiquitination of RIGI to activate the downstream signaling pathway that leads to interferon beta production (PubMed:31006531). UBE2V1-UBE2N together with TRAF3IP2 E3 ubiquitin ligase mediate 'Lys-63'-linked polyubiquitination of TRAF6, a component of IL17A-mediated signaling pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Hypoxia-induced long non-coding RNA LINC00460 promotes p53 mediated proliferation and metastasis of pancreatic cancer by regulating the miR-4689/UBE2V1 axis and sequestering USP10. Publication Status: Online-Only, [RefSeq, PubMed]; Role of Ubiquitin-conjugating enzyme E2 (UBE2) in two immune-mediated inflammatory skin diseases: a mendelian randomization analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin-conjugating E2 enzyme variant proteins constitute a distinct subfamily within the E2 protein family. They have sequence similarity to other ubiquitin-conjugating enzymes but lack the conserved cysteine residue that is critical for the catalytic activity of E2s. The protein encoded by this gene is located in the nucleus and can cause transcriptional activation of the human FOS proto-oncogene. It is thought to be involved in the control of differentiation by altering cell cycle behavior. Alternatively spliced transcript variants encoding multiple isoforms have been described for this gene, and multiple pseudogenes of this gene have been identified. Co-transcription of this gene and the neighboring upstream gene generates a rare transcript (Kua-UEV), which encodes a fusion protein comprised of sequence sharing identity with each individual gene product. [provided by RefSeq, Apr 2012]., [RefSeq]; Ubiquitin-conjugating enzyme V variant 1 enables cellular responses toward fibroblast growth factor signaling in endothelium., [RefSeq, PubMed]; Uev1A promotes breast cancer cell migration by up-regulating CT45A expression via the AKT pathway. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P629;Q13403;Q13532;Q5TGE0;Q5TGE3;Q96H34;Q9GZT0;Q9GZW1;Q9H4J3;Q9H4J4;Q9UKL1;Q9UM48;Q9UM49;Q9UM50",
        "ec_number_list": [],
        "go_molecular_function": "GO:0031624 ubiquitin conjugating enzyme binding;GO:0061631 ubiquitin conjugating enzyme activity",
        "go_cellular_component": "GO:0031371 ubiquitin conjugating enzyme complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0030154 cell differentiation;GO:0006355 regulation of DNA-templated transcription;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0045893 positive regulation of DNA-templated transcription;GO:0000209 protein polyubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 30.3,
        "record_id": "Q13404-4",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BQS7-1",
        "uniprot_id": [
            {
                "id": "HEPH_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BQS7",
                "type": "external"
            }
        ],
        "mass": 130449.0,
        "length": 1158,
        "protein_name": "Hephaestin",
        "gene_name": "HEPH",
        "organism": "Human",
        "refseq_name": "hephaestin isoform b",
        "refseq_ac": [
            {
                "id": "NP_055614",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055614",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEPH; KIAA0698; PRO6242",
        "gene_names_refseq": "CPL; HEPH",
        "protein_names_uniprotkb": "Hephaestin; 1.16.3.1; Hp",
        "protein_names_refseq": "hephaestin isoform b",
        "tax_id": 9606,
        "disease": "glaucoma (Disease Ontology:DOID:1686)",
        "pathway": " (hsa:9843);  (R-HSA-425410);  (R-HSA-5655799);  (R-HSA-917937)",
        "pathway_count": 4,
        "publication_count": 90,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10597293;10625641;11237011;11323407;11431687;11734551;11891802;11932491;12091366;12453412;12504026;12730114;12958161;12975309;14576842;15001581;15044468;15201052;15531878;15537541;15692071;15804357;16143108;16274220;16351644;16377569;16407072;16510471;16813613;16984228;17211682;17486601;18194661;19021540;19452451;1946430;19762596;19762597;20019163;20550936;2154449;22341971;22341972;22961397;23186163;23584533;23615448;24714562;25319704;25576301;25645385;25813380;25892735;26154972;27397612;27862975;28832583;28904123;29557506;29769354;29786170;29789417;30429286;30647129;30755481;31154438;31611695;31844290;31848261;31973819;32157095;32350084;32502341;33592498;33912179;34171305;35051231;35251023;35580925;36284347;36600108;37074911;37277838;37938771;7983023;8041788;8695634;9207117",
        "class_list": "",
        "function": "Association between iron metabolism and SARS-COV-2 infection, determined by ferritin, hephaestin and hypoxia-induced factor-1 alpha levels in COVID-19 patients., [RefSeq, PubMed]; Iron supplementation increased surface expression of the iron-efflux complex, and copper depletion knocked down hephaestin (Heph) activity and decreased ferroportin (Fpn) membrane localization., [RefSeq, PubMed]; Location was observed on or near the cell surface suggesting it might participate in surface membrane transport of iron, [RefSeq, PubMed]; Multifunctional blue, copper-binding (6-7 atoms per molecule) glycoprotein. It has ferroxidase activity oxidizing Fe(2+) to Fe(3+) without releasing radical oxygen species. It is involved in iron transport across the cell membrane. Copper ions provide a large number of enzymatic activites. Oxidizes highly toxic ferrous ions to the ferric state for further incorporation onto apo-transferrins, catalyzes Cu(+) oxidation and promotes the oxidation of biogenic amines such as norepinephrin and serotonin. Provides Cu(2+) ions for the ascorbate-mediated deaminase degradation of the heparan sulfate chains of GPC1. Has glutathione peroxidase-like activity, can remove both hydrogen peroxide and lipid hydroperoxide in the presence of thiols. Also shows NO-oxidase and NO2 synthase activities that determine endocrine NO homeostasis., [UniProtKB, UniProtKB]; Plasma membrane ferroxidase that mediates the extracellular conversion of ferrous/Fe(2+) iron into its ferric/Fe(3+) form. Couples ferroportin which specifically exports ferrous/Fe(2+) iron from cells to transferrin that only binds and shuttles extracellular ferric/Fe(3+) iron throughout the body (PubMed:22961397, PubMed:37277838). By helping iron transfer from cells to blood mainly contributes to dietary iron absorption by the intestinal epithelium and more generally regulates iron levels in the body (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The gene structure, spanning approximately 100 kb, was assembled from the cDNA clones and the chromosome X genomic sequence data. Modelling supports its role as a membrane-tethered ferroxidase., [RefSeq, PubMed]; This gene encodes a member of the multicopper oxidase protein family. The encoded protein is involved in the transport of dietary iron from epithelial cells of the intestinal lumen into the circulatory system, and may be involved in copper transport and homeostasis. In mouse, defects in this gene can lead to severe microcytic anemia. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]., [RefSeq]; Zinc induces iron egress from intestinal Caco-2 cells via induction of Hephaestin: A role for PI3K in intestinal iron absorption., [RefSeq, PubMed]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 7,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 39,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AJX8;D3DVT7;E9PHN8;O75180;Q6UW45;Q9C058",
        "ec_number_list": [
            {
                "id": "1.11.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "1.16.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1",
                "type": "external"
            },
            {
                "id": "1.16.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4",
                "type": "external"
            },
            {
                "id": "1.11.1.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.12",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "5.3.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005507 copper ion binding;GO:0004322 ferroxidase activity;GO:0004602 glutathione peroxidase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0016020 membrane;GO:0005615 extracellular space",
        "go_biological_process": "GO:0006826 iron ion transport;GO:0060586 multicellular organismal-level iron ion homeostasis;GO:0160179 intestinal iron absorption;GO:1904040 positive regulation of iron export across plasma membrane;GO:0006811 monoatomic ion transport",
        "synthesized_glycan_count": 0,
        "hit_score": 10.1,
        "record_id": "Q9BQS7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P10072-1",
        "uniprot_id": [
            {
                "id": "ZN875_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P10072",
                "type": "external"
            }
        ],
        "mass": 75128.0,
        "length": 659,
        "protein_name": "Zinc finger protein 875",
        "gene_name": "ZNF875",
        "organism": "Human",
        "refseq_name": "zinc finger protein 875 isoform c",
        "refseq_ac": [
            {
                "id": "NP_001316692",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316692",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZNF875; HKR1",
        "gene_names_refseq": "HKR1; ZNF875",
        "protein_names_uniprotkb": "Zinc finger protein 875; Krueppel-related zinc finger protein 1; Protein HKR1",
        "protein_names_refseq": "HKR1, GLI-Kruppel zinc finger family member; Krueppel-related zinc finger protein 1; oncogene HKR1; zinc finger protein 875 isoform c",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284459);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 18,
        "publication_id_list": "10235266;10330177;11237011;11395415;14519192;15175151;15896744;16606702;16719718;2163759;26787842;2850480;29394898;8183939;8769649;9637681;9653119;9813242",
        "class_list": "",
        "function": "Ahk1 is a scaffold protein in the HKR1 subbranch and prevents incorrect signal flow from Hkr1 to Kss1 Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The methylation profile combination of HKR1, ROD1, and NLRC5 could be a promising biomarker for aging in Hainan centenarians Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MRS7;Q6PJD0;Q9BSW9;Q9UM09",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "P10072-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UHF4-1",
        "uniprot_id": [
            {
                "id": "I20RA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UHF4",
                "type": "external"
            }
        ],
        "mass": 62485.0,
        "length": 553,
        "protein_name": "Interleukin-20 receptor subunit alpha",
        "gene_name": "IL20RA",
        "organism": "Human",
        "refseq_name": "interleukin-20 receptor subunit alpha isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001265651",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265651",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL20RA; PRO1315",
        "gene_names_refseq": "CRF2-8; IL-20R-alpha; IL-20R1; IL-20RA; IL20RA",
        "protein_names_uniprotkb": "Interleukin-20 receptor subunit alpha; CRF2-8; Cytokine receptor class-II member 8; Cytokine receptor family 2 member 8; IL-20 receptor subunit alpha; IL-20R-alpha; IL-20R1; IL-20RA; ZcytoR7",
        "protein_names_refseq": "class II cytokine receptor ZCYTOR7; cytokine receptor family 2 member 8; interleukin 20 receptor alpha subunit; interleukin 20 receptor, alpha; interleukin-20 receptor I; interleukin-20 receptor subunit alpha isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:53832);  (R-HSA-5684996);  (R-HSA-8854691)",
        "pathway_count": 3,
        "publication_count": 50,
        "publication_id_list": "10875937;11163236;11196675;11237011;11390453;11390454;11481447;11564763;11706020;12087100;12351624;12469119;12975309;14580208;14764663;15120653;15166220;15178681;15340161;15919823;1662392;16750817;16982608;17878297;18599299;18669613;18830264;18941194;19457860;19535621;20462497;20671117;20966397;21098725;22802649;22962576;24958902;25004819;27133025;28458652;28904123;30429286;31152679;33456560;34283251;35051231;36284347;7512451;7543512;8830676",
        "class_list": "",
        "function": "Forms stable complex with interleukin-19 and interleukin-20 [IL-20R1][IL-20R2], [RefSeq, PubMed]; IL20RA signaling enhances stemness and promotes the formation of an immunosuppressive microenvironment in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer., [RefSeq, PubMed]; Multiple sequence alignment explains the stabilizing effect of the mutated residues in the IL-24 variants by their presence in the related and more stable cytokines IL-20 and IL-19, [RefSeq, PubMed]; The IL20RA/IL20RB dimer is a receptor for IL19, IL20 and IL24. The IL20RA/IL10RB dimer is a receptor for IL26., [UniProtKB]; This gene encodes a member of the type II cytokine receptor family. The encoded protein is a subunit of the receptor for interleukin 20, a cytokine that may be involved in epidermal function. The interleukin 20 receptor is a heterodimeric complex consisting of the encoded protein and interleukin 20 receptor beta. This gene and interleukin 20 receptor beta are highly expressed in skin, and are upregulated in psoriasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DLR5;F5H675;Q14CW2;Q6UWA9;Q96SH8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004896 cytokine receptor activity;GO:0042015 interleukin-20 binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0030316 osteoclast differentiation;GO:0032736 positive regulation of interleukin-13 production;GO:0006954 inflammatory response;GO:0042127 regulation of cell population proliferation;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q9UHF4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q3ZCQ3-1",
        "uniprot_id": [
            {
                "id": "F174B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q3ZCQ3",
                "type": "external"
            }
        ],
        "mass": 16967.0,
        "length": 159,
        "protein_name": "Membrane protein FAM174B",
        "gene_name": "FAM174B",
        "organism": "Human",
        "refseq_name": "membrane protein FAM174B precursor",
        "refseq_ac": [
            {
                "id": "NP_997329",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997329",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM174B",
        "gene_names_refseq": "FAM174B",
        "protein_names_uniprotkb": "Membrane protein FAM174B",
        "protein_names_refseq": "membrane protein FAM174B precursor; membrane protein FAM174B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:400451)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;22544926;23090970;23481700;24190977;24715725;25502872;26154972;27846572;27920218;28832583;29242379;29557506;29851555;31998317;32502341;33141586;33298915;33968037;34433824;35154160;37074911",
        "class_list": "",
        "function": "Essential for Golgi structural integrity., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 9507,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3ZCR9;Q8NBH7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007030 Golgi organization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q3ZCQ3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14289-1",
        "uniprot_id": [
            {
                "id": "FAK2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14289",
                "type": "external"
            }
        ],
        "mass": 115875.0,
        "length": 1009,
        "protein_name": "Protein-tyrosine kinase 2-beta",
        "gene_name": "PTK2B",
        "organism": "Human",
        "refseq_name": "protein-tyrosine kinase 2-beta isoform a",
        "refseq_ac": [
            {
                "id": "NP_004094",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004094",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTK2B; FAK2; PYK2; RAFTK",
        "gene_names_refseq": "CADTK; CAKB; FADK2; FAK2; PKB; PTK2B; PTK; PYK2; RAFTK",
        "protein_names_uniprotkb": "Protein-tyrosine kinase 2-beta; 2.7.10.2; CADTK; CAK-beta; CAKB; Calcium-dependent tyrosine kinase; Calcium-regulated non-receptor proline-rich tyrosine kinase; Cell adhesion kinase beta; FADK 2; Focal adhesion kinase 2; Proline-rich tyrosine kinase 2; RAFTK; Related adhesion focal tyrosine kinase",
        "protein_names_refseq": "CAK-beta; FADK 2; PTK2B protein tyrosine kinase 2 beta; calcium-dependent tyrosine kinase; calcium-regulated non-receptor proline-rich tyrosine kinase; cell adhesion kinase beta; focal adhesion kinase 2; proline-rich tyrosine kinase 2; protein kinase B; protein-tyrosine kinase 2-beta isoform a; related adhesion focal tyrosine kinase",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); diabetic angiopathy (Disease Ontology:DOID:11713); breast cancer (Disease Ontology:DOID:1612); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316); glomerulonephritis (Disease Ontology:DOID:2921); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780)",
        "pathway": " (hsa:2185);  (R-HSA-391160);  (R-HSA-4420097);  (R-HSA-9013420);  (R-HSA-9020558)",
        "pathway_count": 5,
        "publication_count": 325,
        "publication_id_list": "10022920;10037737;10075701;10187855;10207622;10373549;10385529;10395673;10469599;10521452;10572074;10637513;10677529;10692392;10744763;10749680;10769033;10788440;10825200;10867021;10880513;11007481;11007796;11149924;11149930;11237011;11278486;11337490;11373274;11459829;11493697;11520052;11535620;11577096;11602570;11695992;11696015;11698270;11820787;12023008;12042320;12063569;12134158;12164932;12196460;12214271;12215529;12231407;12391143;12464388;12514172;12522270;12660731;12771146;12810700;12820653;12893833;14531999;14585963;14637150;14724572;14996908;15026417;15050747;15070849;15104674;15105428;15126359;15166227;15178252;15181089;15213840;15247219;1526987;15294972;15308668;15347471;15350535;15383453;15556869;15585656;15688067;15695828;15888917;15962004;16128807;16213021;16336962;16397254;16414994;16477002;16574377;16760434;16774943;16966330;16998541;17016520;17030947;17055484;17070842;17188509;17192257;17199126;17205062;17237347;17293873;17321230;17329398;17344846;17369261;17389395;17504809;17581824;17634955;17684059;17686471;18086875;18088087;18339875;18367725;18535108;18587400;18657508;18691976;18718528;18765415;18951788;18991276;19064640;19086031;19144640;19207108;19230644;19244237;19267251;19358827;19369195;19380485;19412549;19428251;19628875;19648005;19651622;19861182;19880522;19919693;19933999;20001213;20028775;20058876;20153492;20156366;20180987;20308428;20332118;20381867;20507587;20521079;20547754;20658524;20668162;20826662;21196189;21357692;21429240;21445309;21508312;21533080;21565175;21859844;22314813;22327215;22689825;22802128;22859931;23186163;23216836;23300847;23481700;23690212;23922106;24366607;24714562;24715725;24716819;24965120;25090023;25418920;25433371;25505266;25576301;25734515;25889845;25892735;26084289;26154972;26202465;26375851;26484898;26598620;26728094;26756739;26811146;26866924;26992070;27543614;27602957;27613122;27846572;27862975;27920218;27986865;28063628;28218747;28228285;28832583;28834231;28904123;29133485;29242379;29393594;29432553;29437277;29438996;29491534;29493099;29508533;29557506;29595187;29632046;29632711;29786170;29789417;29920512;29930882;30020827;30250159;30301600;30315122;30379171;30410026;30429286;30433799;30571746;31217245;31519735;31844290;31871319;32157095;32238362;32265295;32350084;32357974;32387766;32502341;32737221;32760285;32792487;32897882;32938616;32983136;33091337;33141586;33273492;33277387;33298915;33392160;33592498;33691108;33717175;33785524;33912179;33936100;33968037;34078123;34171305;34185709;34211107;34509645;34561969;34932366;35051231;35154160;35580925;35607451;36215666;36284347;37586982;37894811;37938771;38321895;38732165;7499242;7499411;7509446;7544443;7568001;7600304;7673154;7973658;8022485;8294403;8617235;8631883;8643566;8670418;8695788;8700888;8702919;8838818;8849729;8986718;9030599;9062191;9099726;9182576;9242628;9393975;9398617;9422762;9472046;9512511;9545257;9560226;9582355",
        "class_list": "",
        "function": "Ethnicity-Based Variations in Focal Adhesion Kinase Signaling in Glioblastoma Gene Expression: A Study of the Puerto Rican Hispanic Population. Publication Status: Online-Only, [RefSeq, PubMed]; Microglia PTK2B/Pyk2 in the Pathogenesis of Alzheimer's Disease. Review article, [RefSeq, PubMed]; Non-receptor protein-tyrosine kinase that regulates reorganization of the actin cytoskeleton, cell polarization, cell migration, adhesion, spreading and bone remodeling. Plays a role in the regulation of the humoral immune response, and is required for normal levels of marginal B-cells in the spleen and normal migration of splenic B-cells. Required for normal macrophage polarization and migration towards sites of inflammation. Regulates cytoskeleton rearrangement and cell spreading in T-cells, and contributes to the regulation of T-cell responses. Promotes osteoclastic bone resorption; this requires both PTK2B/PYK2 and SRC. May inhibit differentiation and activity of osteoprogenitor cells. Functions in signaling downstream of integrin and collagen receptors, immune receptors, G protein-coupled receptors (GPCR), cytokine, chemokine and growth factor receptors, and mediates responses to cellular stress. Forms multisubunit signaling complexes with SRC and SRC family members upon activation; this leads to the phosphorylation of additional tyrosine residues, creating binding sites for scaffold proteins, effectors and substrates. Regulates numerous signaling pathways. Promotes activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Promotes activation of NOS3. Regulates production of the cellular messenger cGMP. Promotes activation of the MAP kinase signaling cascade, including activation of MAPK1/ERK2, MAPK3/ERK1 and MAPK8/JNK1. Promotes activation of Rho family GTPases, such as RHOA and RAC1. Recruits the ubiquitin ligase MDM2 to P53/TP53 in the nucleus, and thereby regulates P53/TP53 activity, P53/TP53 ubiquitination and proteasomal degradation. Acts as a scaffold, binding to both PDPK1 and SRC, thereby allowing SRC to phosphorylate PDPK1 at 'Tyr-9, 'Tyr-373', and 'Tyr-376'. Promotes phosphorylation of NMDA receptors by SRC family members, and thereby contributes to the regulation of NMDA receptor ion channel activity and intracellular Ca(2+) levels. May also regulate potassium ion transport by phosphorylation of potassium channel subunits. Phosphorylates SRC; this increases SRC kinase activity. Phosphorylates ASAP1, NPHP1, KCNA2 and SHC1. Promotes phosphorylation of ASAP2, RHOU and PXN; this requires both SRC and PTK2/PYK2., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; PYK2, a hub of signaling networks in breast cancer progression. Review article, [RefSeq, PubMed]; This gene encodes a cytoplasmic protein tyrosine kinase which is involved in calcium-induced regulation of ion channels and activation of the map kinase signaling pathway. The encoded protein may represent an important signaling intermediate between neuropeptide-activated receptors or neurotransmitters that increase calcium flux and the downstream signals that regulate neuronal activity. The encoded protein undergoes rapid tyrosine phosphorylation and activation in response to increases in the intracellular calcium concentration, nicotinic acetylcholine receptor activation, membrane depolarization, or protein kinase C activation. This protein has been shown to bind CRK-associated substrate, nephrocystin, GTPase regulator associated with FAK, and the SH2 domain of GRB2. The encoded protein is a member of the FAK subfamily of protein tyrosine kinases but lacks significant sequence similarity to kinases from other subfamilies. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Thrombin-Induced COX-2 Expression and PGE2 Synthesis in Human Tracheal Smooth Muscle Cells: Role of PKCdelta/Pyk2-Dependent AP-1 Pathway Modulation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 34,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 9,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DST0;Q13475;Q14290;Q16709;Q6PID4",
        "ec_number_list": [
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0030546 signaling receptor activator activity;GO:0035255 ionotropic glutamate receptor binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0017146 NMDA selective glutamate receptor complex;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:0007165 signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0007229 integrin-mediated signaling pathway;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 32.8,
        "record_id": "Q14289-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UWH4-1",
        "uniprot_id": [
            {
                "id": "GAK1B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UWH4",
                "type": "external"
            }
        ],
        "mass": 57552.0,
        "length": 519,
        "protein_name": "Golgi-associated kinase 1B",
        "gene_name": "GASK1B",
        "organism": "Human",
        "refseq_name": "Golgi-associated kinase 1B isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001026870",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026870",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GASK1B; AD021; C4orf18; ENED; FAM198B; PRO6001",
        "gene_names_refseq": "AD021; AD036; C4orf18; ENED; FAM198B; GASK1B",
        "protein_names_uniprotkb": "Golgi-associated kinase 1B; Expressed in nerve and epithelium during development; Protein FAM198B",
        "protein_names_refseq": "Golgi-associated kinase 1B isoform 1; expressed in nerve and epithelium during development; family with sequence similarity 198 member B; protein FAM198B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51313)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;11237011;11256614;12975309;23481700;23584533;25813380;27862975;29217529;29557506;29786170;30459171;31154438;31848261;32157095;32387766;32983136;33592498;35251023;35580925",
        "class_list": "",
        "function": "Data show that matrix metalloproteinase 1 (MMP-1) as a critical downstream target of golgi associated kinase 1B (FAM198B) and implicate FAM198B as a potential tumor suppressor and to be a prognostic marker in lung adenocarcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
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        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q498Z3;Q6IAF9;Q6ZMF2;Q86XL0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q6UWH4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P24592-1",
        "uniprot_id": [
            {
                "id": "IBP6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P24592",
                "type": "external"
            }
        ],
        "mass": 25322.0,
        "length": 240,
        "protein_name": "Insulin-like growth factor-binding protein 6",
        "gene_name": "IGFBP6",
        "organism": "Human",
        "refseq_name": "insulin-like growth factor-binding protein 6 precursor",
        "refseq_ac": [
            {
                "id": "NP_002169",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002169",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IGFBP6; IBP6",
        "gene_names_refseq": "IBP6; IGFBP6",
        "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 6; IBP-6; IGF-binding protein 6; IGFBP-6",
        "protein_names_refseq": "IBP-6; IGF binding protein 6; IGFBP-6; insulin-like growth factor-binding protein 6 precursor",
        "tax_id": 9606,
        "disease": "leiomyoma (Disease Ontology:DOID:127); breast cancer (Disease Ontology:DOID:1612); in situ carcinoma (Disease Ontology:DOID:8719); neovascular inflammatory vitreoretinopathy (Disease Ontology:DOID:9719); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:3489);  (R-HSA-381426)",
        "pathway_count": 2,
        "publication_count": 96,
        "publication_id_list": "10.1021/acs.analchem.6b02887;10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10026136;10077652;10087296;10218588;10329650;10512690;10614670;10681634;10810289;10898936;10912521;10951195;10990447;11158056;11237011;11250653;11264294;11316783;11522292;11606061;11739083;11751371;11788658;12241545;12379487;12466191;12810533;12904166;1370451;1383255;15126567;15308688;15469690;15485880;15525596;15642270;1697583;17047378;1709161;1719383;17249697;17312271;17985932;1850257;19838169;2154495;21548981;23234360;23584533;24003225;2476804;2479552;2551732;25576301;25813380;26091039;26598643;28035807;29557506;30237853;30429286;30459171;32350084;33981976;34171305;35051231;35251023;35457175;35654889;36946206;37336811;39275851;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;8781553;8817670;8894645;8964575;9497324;9572875;9709957;9733769;9786878;9922210",
        "class_list": "",
        "function": "Effect of IGFBP6 Knockdown on Proteins Regulating Exosome Synthesis and Secretion in MDA-MB-231 Cell Line., [RefSeq, PubMed]; Evaluation of SNPs from human IGFBP6 associated with gene expression: an in-silico study., [RefSeq, PubMed]; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Activates the MAPK signaling pathway and induces cell migration (PubMed:24003225)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; IGFBP-6: At the Crossroads of Immunity, Tissue Repair and Fibrosis. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Lactate modulates microglia polarization via IGFBP6 expression and remodels tumor microenvironment in glioblastoma. Erratum:[Cancer Immunol Immunother. 2023 Jan;72(1):21. doi: 10.1007/s00262-022-03243-z. PMID: 35821528], [RefSeq, PubMed]; Prognostic Value of IGFBP6 in Breast Cancer: Focus on Glucometabolism., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 17,
        "reported_c_glycosites_with_glycan": 0,
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        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 5,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14492",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042802 identical protein binding;GO:0001968 fibronectin binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0042568 insulin-like growth factor binary complex",
        "go_biological_process": "GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0016477 cell migration;GO:0043410 positive regulation of MAPK cascade;GO:0090090 negative regulation of canonical Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 12.1,
        "record_id": "P24592-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100010000000.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P42694-1",
        "uniprot_id": [
            {
                "id": "HELZ_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P42694",
                "type": "external"
            }
        ],
        "mass": 218970.0,
        "length": 1942,
        "protein_name": "ATP-dependent RNA helicase with zinc finger domain",
        "gene_name": "HELZ",
        "organism": "Human",
        "refseq_name": "putative helicase with zinc finger domain isoform X4",
        "refseq_ac": [
            {
                "id": "XP_047293181",
                "url": "https://www.ncbi.nlm.nih.gov/protein/XP_047293181",
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            }
        ],
        "gene_names_uniprotkb": "HELZ; DRHC; KIAA0054",
        "gene_names_refseq": "DHRC; DRHC; HELZ; HUMORF5",
        "protein_names_uniprotkb": "ATP-dependent RNA helicase with zinc finger domain; 3.6.4.13; Down-regulated in human cancers protein",
        "protein_names_refseq": "putative helicase with zinc finger domain isoform X4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9931)",
        "pathway_count": 1,
        "publication_count": 82,
        "publication_id_list": "10.1101/2023.09.13.557529;10471385;11237011;12691822;15235609;15302935;16497976;17081983;18669648;19413330;19690332;20068231;21406692;21765940;22544926;23186163;23481700;24129315;24714562;24715725;25418920;25576301;25645385;25880248;25892735;26154972;26375851;26728094;26811146;26992070;27397612;27846572;28904123;29242379;29437277;29493099;29557506;30379171;30429286;30484775;31217245;31492838;31570513;31844290;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34185709;34211107;34509645;34561969;34932366;35051231;35254053;35318648;35561310;35580925;36010968;36215666;36284347;37938771;38665916;38838015",
        "class_list": "",
        "function": "ATP-dependent RNA helicase that promotes degradation of mRNAs via its association with the CCR4-NOT deadenylase complex, leading to deadenylation, decapping, and subsequent degradation of target mRNAs (PubMed:31570513). Can repress translation independently of mRNA decay in a manner dependent on both the CCR4-NOT complex and the helicase DDX6 (PubMed:31570513). Involved in promoting cell proliferation, translation initiation, and ribosomal protein S6 (RPS6) phosphorylation (PubMed:21765940)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 2,
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        "biomarker_type": "",
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        "secondary_ac_list": "I6L9H4",
        "ec_number_list": [
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
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            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
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            },
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
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            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
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            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
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            {
                "id": "5.6.2.3",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
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                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
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            {
                "id": "5.6.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5",
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            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
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            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
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            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
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            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
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            },
            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
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            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
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            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "3.1.13.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
                "type": "external"
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            {
                "id": "5.6.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
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            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
                "type": "external"
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            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
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        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008270 zinc ion binding;GO:0016887 ATP hydrolysis activity;GO:0003724 RNA helicase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0043186 P granule",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0017148 negative regulation of translation;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing;GO:1900153 positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "P42694-1",
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        "kg_view_protein": true
    },
    {
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        ],
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        "length": 354,
        "protein_name": "Abasic site processing protein HMCES",
        "gene_name": "HMCES",
        "organism": "Human",
        "refseq_name": "abasic site processing protein HMCES isoform a",
        "refseq_ac": [
            {
                "id": "NP_001006109",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006109",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HMCES; C3orf37; DC12; SRAPD1",
        "gene_names_refseq": "C3orf37; DC12; HMCES; SRAPD1",
        "protein_names_uniprotkb": "Abasic site processing protein HMCES; 3.4.-.-; 4.-.-.-; ES cell-specific 5hmC-binding protein; Embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; Peptidase HMCES; SRAP domain-containing protein 1",
        "protein_names_refseq": "5-hydroxymethylcytosine (hmC) binding, ES cell-specific; ES cell-specific 5hmC-binding protein; SOS response associated peptidase domain containing 1; SRAP domain-containing protein 1; UPF0361 protein C3orf37; abasic site processing protein HMCES isoform a; abasic site processing protein HMCES; embryonic stem cell-specific 5-hydroxymethylcytosine-binding protein; peptidase HMCES; putative endonuclease HMCES; putative peptidase SRAPD1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56941)",
        "pathway_count": 1,
        "publication_count": 88,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;19413330;20068231;23186163;23301498;23481700;23945014;24387984;24679604;24714562;25418920;25471351;25576301;25645385;25755297;26154972;26728094;26992070;27600516;27846572;28218747;28228285;28411811;28510447;28514659;28832583;28834231;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29786170;29789417;30315122;30379171;30410026;30429286;30524438;30554877;30779550;31092671;31154438;31235913;31235915;31806351;31844290;31848261;31998317;32157095;32161166;32265295;32307824;32488085;32492421;32502341;32897882;32938616;32983136;33141586;33214551;33537174;33592498;33691108;33788831;33936100;33968037;33981976;34019948;34087483;34171305;34405274;34561969;34932366;35318648;35450882;35561310;35580925;36010968;36284347;36608669;37519246;37938771;37950866;39894887",
        "class_list": "",
        "function": "It involves in epigenetic changes during the progression of Alzheimer disease pathology., [RefSeq, PubMed]; Its reduction in brain is associate with neuropathology of Alzheimer disease., [RefSeq, PubMed]; Loss of the abasic site sensor HMCES is synthetic lethal with the activity of the APOBEC3A cytosine deaminase in cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites (PubMed:30554877, PubMed:31235913, PubMed:31235915, PubMed:32307824, PubMed:32492421). Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue (PubMed:30554877, PubMed:31235913). Promotes error-free repair by protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks (PubMed:30554877). The HMCES DNA-protein cross-link is then either reversed or degraded (PubMed:30554877, PubMed:36608669, PubMed:37519246, PubMed:37950866). HMCES is able to catalyze the reversal of its thiazolidine cross-link and cycle between a cross-link and a non-cross-linked state depending on DNA context: mediates self-reversal of the thiazolidine cross-link in double stranded DNA, allowing APEX1 to initiate downstream repair of abasic sites (PubMed:37519246, PubMed:37950866). The HMCES DNA-protein cross-link can also be degraded by the SPRTN metalloprotease following unfolding by the BRIP1/FANCJ helicase (PubMed:36608669). Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction (PubMed:31235915, PubMed:31806351). Plays a protective role during somatic hypermutation of immunoglobulin genes in B-cells: acts via its ability to form covalent cross-links with abasic sites, thereby limiting the accumulation of deletions in somatic hypermutation target regions (PubMed:35450882). Also involved in class switch recombination (CSR) in B-cells independently of the formation of a DNA-protein cross-link: acts by binding and protecting ssDNA overhangs to promote DNA double-strand break repair through the microhomology-mediated alternative-end-joining (Alt-EJ) pathway (By similarity). Acts as a protease: mediates autocatalytic processing of its N-terminal methionine in order to expose the catalytic cysteine (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The findings of this study described in this study emphasise the importance of 5hmC in brain development and ageing and will help to better understand the complexity and plasticity of the brain., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NJR9;Q96G34;Q9NRP3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008233 peptidase activity;GO:0003697 single-stranded DNA binding;GO:0140431 DNA-(abasic site) binding;GO:0160129 protein-DNA covalent cross-linking activity;GO:0016829 lyase activity",
        "go_cellular_component": "GO:0005657 replication fork;GO:0005694 chromosome",
        "go_biological_process": "GO:0097681 double-strand break repair via alternative nonhomologous end joining;GO:0006508 proteolysis;GO:0006974 DNA damage response;GO:0016446 somatic hypermutation of immunoglobulin genes;GO:0036297 interstrand cross-link repair",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "Q96FZ2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P14317-1",
        "uniprot_id": [
            {
                "id": "HCLS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P14317",
                "type": "external"
            }
        ],
        "mass": 54014.0,
        "length": 486,
        "protein_name": "Hematopoietic lineage cell-specific protein",
        "gene_name": "HCLS1",
        "organism": "Human",
        "refseq_name": "hematopoietic lineage cell-specific protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_005326",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005326",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HCLS1; HS1",
        "gene_names_refseq": "CTTNL; HCLS1; HS1; lckBP1; p75",
        "protein_names_uniprotkb": "Hematopoietic lineage cell-specific protein; Hematopoietic cell-specific LYN substrate 1; LckBP1; p75",
        "protein_names_refseq": "hematopoietic lineage cell-specific protein isoform 1; hematopoietic lineage cell-specific protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3059)",
        "pathway_count": 1,
        "publication_count": 98,
        "publication_id_list": "10066823;10806407;11237011;12522270;15144186;15570572;15795233;16094384;16782030;18292551;19608861;19690332;21993680;22706990;23186163;23325840;23481700;24275569;24366607;24714562;24715725;25418920;25502872;2587259;25880248;25892735;26110819;26154972;26375851;26728094;26758079;26811146;26992070;27655845;27846572;27920218;28063628;28228285;28465529;28467828;28514659;28832583;28834231;28904123;29242379;29351928;29393594;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30220969;30315122;30429286;30524438;30537294;31217245;31611695;31844290;32157095;32265295;32350084;32357974;32387766;32502341;32897882;32938750;32983136;33123756;33691108;33717175;33912179;33936100;34171305;34433824;34932366;35051231;35132862;35154160;35494241;35561310;35580925;35705054;36284347;36581221;37938771;38847679;40307207;40914422;7682714;8611520;8713105;9058808;9104825;9183008",
        "class_list": "",
        "function": "Correlation between elevated HCLS1 levels and heart failure: A diagnostic biomarker., [RefSeq, PubMed]; Hematopoietic cell-specific Lyn substrate, HCLS1, is a versatile actin-binding protein in leukocytes. (Review) Review article, [RefSeq, PubMed]; Substrate of the antigen receptor-coupled tyrosine kinase. Plays a role in antigen receptor signaling for both clonal expansion and deletion in lymphoid cells. May also be involved in the regulation of gene expression., [UniProtKB, UniProtKB, UniProtKB]; These studies indicate HS1 plays an important role in ROR1-dependent Wnt5a-enhanced chemokine-directed leukemia-cell migration., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 17,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DQ69;Q53Y93;Q6IBK9;Q9UDK0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019901 protein kinase binding;GO:0051015 actin filament binding;GO:0035591 signaling adaptor activity;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0030854 positive regulation of granulocyte differentiation;GO:0042307 positive regulation of protein import into nucleus;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007015 actin filament organization;GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 10.4,
        "record_id": "P14317-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H098-1",
        "uniprot_id": [
            {
                "id": "F107B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H098",
                "type": "external"
            }
        ],
        "mass": 15558.0,
        "length": 131,
        "protein_name": "Protein FAM107B",
        "gene_name": "FAM107B",
        "organism": "Human",
        "refseq_name": "protein FAM107B isoform a",
        "refseq_ac": [
            {
                "id": "NP_001269624",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269624",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM107B; C10orf45",
        "gene_names_refseq": "C10orf45; FAM107B; HITS",
        "protein_names_uniprotkb": "Protein FAM107B",
        "protein_names_refseq": "FAM107B/CDNF fusion; heat shock-inducible tumor small protein; protein FAM107B isoform a; protein FAM107B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83641)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "11230166;11237011;16385451;19913121;20628086;22825356;23481700;26992070;28675500;29242379;29314611;29393594;29508533;29557506;29632046;29632711;30833945;31844290;32350084;32983136;33141586;36284347",
        "class_list": "",
        "function": "Authors first provide experimental evidence suggesting that FAM107B was downregulated by S100A4 in gastric cancer MGC803 cells. And FAM107B at least partially mediates the biological effect of S100A4 in the cells., [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; These results show that loss of HITS (FAM107B) expression is a common phenomenon observed in cancers of distinct organs and involved in tumor development and proliferation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1P4;D3DRT2;Q5T9K7;Q5T9K8;Q6ZSI4",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q9H098-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6P4H8-1",
        "uniprot_id": [
            {
                "id": "ACKMT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P4H8",
                "type": "external"
            }
        ],
        "mass": 26110.0,
        "length": 233,
        "protein_name": "ATP synthase subunit C lysine N-methyltransferase",
        "gene_name": "ATPSCKMT",
        "organism": "Human",
        "refseq_name": "ATP synthase subunit C lysine N-methyltransferase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001245317",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245317",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ATPSCKMT; FAM173B",
        "gene_names_refseq": "ATPSCKMT; FAM173B; JS-2; hFAM173B",
        "protein_names_uniprotkb": "ATP synthase subunit C lysine N-methyltransferase; 2.1.1.-; Protein N-lysine methyltransferase FAM173B; hFAM173B",
        "protein_names_refseq": "ATP synthase subunit C lysine N-methyltransferase isoform 2; ATP synthase subunit C lysine N-methyltransferase; family with sequence similarity 173 member B; protein FAM173B; protein N-lysine methyltransferase FAM173B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:134145)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;21802380;24715725;26154972;27920218;28832583;28904123;29242379;29393594;29444090;29632711;30530489;31217245;31844290;32897882;32938616;33067627;33912179;33968037;35051231;36241641",
        "class_list": "",
        "function": "Expression of mitochondrial TSPO and FAM173B is associated with inflammation and symptoms in patients with painful knee osteoarthritis., [RefSeq, PubMed]; Genetic alteration of JS-2 was found to be related to location, pathological subtypes and staging of colorectal cancer., [RefSeq, PubMed]; It has been identified FAM173B as the long-sought KMT responsible for methylation of ATP synthase c-subunit (ATPSc), a key protein in cellular ATP production, and have demonstrated functional significance of ATPSc methylation., [RefSeq, PubMed]; Mitochondrial protein-lysine N-methyltransferase that trimethylates ATP synthase subunit C, ATP5MC1 and ATP5MC2. Trimethylation is required for proper incorporation of the C subunit into the ATP synthase complex and mitochondrial respiration (PubMed:29444090, PubMed:30530489). Promotes chronic pain (PubMed:29444090). Involved in persistent inflammatory and neuropathic pain: methyltransferase activity in the mitochondria of sensory neurons promotes chronic pain via a pathway that depends on the production of reactive oxygen species (ROS) and on the engagement of spinal cord microglia (PubMed:29444090)., [UniProtKB, PubMed, PubMed]; We uncover a role for methyltransferase activity of FAM173B in the neurobiology of pain. These results also highlight FAM173B methyltransferase activity as a potential therapeutic target to treat debilitating chronic pain conditions Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
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        "reported_mutagensis": 2,
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        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DT41;B4DXK2;E9PBZ4",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "2.1.1.359",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359",
                "type": "external"
            },
            {
                "id": "2.1.1.372",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0030061 mitochondrial crista",
        "go_biological_process": "GO:0018022 peptidyl-lysine methylation;GO:0018023 peptidyl-lysine trimethylation;GO:1904058 positive regulation of sensory perception of pain;GO:1905273 positive regulation of proton-transporting ATP synthase activity, rotational mechanism;GO:1905706 regulation of mitochondrial ATP synthesis coupled proton transport",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q6P4H8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P78346-1",
        "uniprot_id": [
            {
                "id": "RPP30_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P78346",
                "type": "external"
            }
        ],
        "mass": 29321.0,
        "length": 268,
        "protein_name": "Ribonuclease P protein subunit p30",
        "gene_name": "RPP30",
        "organism": "Human",
        "refseq_name": "ribonuclease P protein subunit p30 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001098016",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098016",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RPP30; RNASEP2",
        "gene_names_refseq": "RPP30; TSG15",
        "protein_names_uniprotkb": "Ribonuclease P protein subunit p30; RNase P subunit 2; RNaseP protein p30",
        "protein_names_refseq": "RNase P subunit 2; RNaseP protein p30; ribonuclease P protein subunit p30 isoform a; ribonuclease P protein subunit p30; ribonuclease P/MRP 30kDa subunit",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10556);  (R-HSA-6784531);  (R-HSA-6791226)",
        "pathway_count": 3,
        "publication_count": 134,
        "publication_id_list": "10444065;11237011;11455963;11727826;11871657;11922599;12068309;12138183;12150911;12526808;12711671;12729736;15109492;15317868;16037817;16043514;16361254;16710424;16723659;16738141;17081983;17189298;17204286;17224653;17287340;17322306;17353269;17412707;18065403;18212344;18220336;18226598;18438418;18452278;18767875;18809514;18984158;19106111;19332556;19564402;19690332;19801658;20038530;20056613;20068231;20531386;20798176;20805244;20819938;21036871;21063389;21097556;21311021;21450806;21559454;21593607;22072790;22190735;22195017;22223895;22916032;22944664;23186163;23439679;23481700;23482395;2388630;24275569;24424021;24550520;2470644;24715725;24870230;25489052;25525153;25640237;25645385;25849199;25969445;26154972;26237581;26992070;27846572;27862975;27920218;28115465;28218747;28832583;28834231;28904123;29242379;29493099;29508533;29557506;30454648;30484775;30833945;31154438;31217245;31530632;31844290;31998317;32157095;32161166;32357974;32488085;32702667;32897882;32938616;33141586;33298915;33537174;33592498;33936100;33968037;34019948;34171305;34211107;34932366;35051231;35580925;36010968;36241641;37217939;37938771;40914422;6930639;7759547;7828588;9037013;9482744;9512417;9630247;9660920",
        "class_list": "",
        "function": "Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends (PubMed:30454648, PubMed:9037013, PubMed:9630247). Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences (PubMed:28115465)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; RPP30, a transcriptional regulator, is a potential pathogenic factor in glioblastoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R799;E9PB02",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0004526 ribonuclease P activity;GO:0033204 ribonuclease P RNA binding",
        "go_cellular_component": "GO:0005655 nucleolar ribonuclease P complex;GO:0030681 multimeric ribonuclease P complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000172 ribonuclease MRP complex",
        "go_biological_process": "GO:0006396 RNA processing;GO:0008033 tRNA processing;GO:0006364 rRNA processing;GO:0001682 tRNA 5'-leader removal",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "P78346-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WVB3-1",
        "uniprot_id": [
            {
                "id": "HEXD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WVB3",
                "type": "external"
            }
        ],
        "mass": 53790.0,
        "length": 486,
        "protein_name": "Hexosaminidase D",
        "gene_name": "HEXD",
        "organism": "Human",
        "refseq_name": "hexosaminidase D isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001317471",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317471",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEXD; HEXDC",
        "gene_names_refseq": "HEXDC; HEXD",
        "protein_names_uniprotkb": "Hexosaminidase D; 3.2.1.52; Beta-N-acetylhexosaminidase; Beta-hexosaminidase D; Hexosaminidase domain-containing protein; N-acetyl-beta-galactosaminidase",
        "protein_names_refseq": "N-acetyl-beta-galactosaminidase; beta-N-acetylhexosaminidase; beta-hexosaminidase D; hexosaminidase (glycosyl hydrolase family 20, catalytic domain) containing; hexosaminidase D isoform 2; hexosaminidase D, cytosolic; hexosaminidase domain-containing protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284004)",
        "pathway_count": 1,
        "publication_count": 47,
        "publication_id_list": "11237011;19040401;21265931;21672370;22515481;23099419;23481700;24715725;26154972;26992070;27149221;27846572;27862975;27893789;27920218;28228285;28832583;28834231;28904123;29557506;29632711;30315122;30429286;30833945;31154438;31530632;31844290;32157095;32161166;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33392160;33912179;33968037;34171305;34509645;34932366;35051231;35318648;35580925;36215666;37938771",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "Has hexosaminidase activity. Responsible for the cleavage of the monosaccharides N-acetylglucosamine (GlcNAc) and N-acetylgalactosamine (GalNAc) from cellular substrates. Has a preference for galactosaminide over glucosaminide substrates (PubMed:27149221)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; In normoalbuminuric/microalbuminuric patients with essential hypertension renal impairment measured by e-GFR is related to the increased urinary NAG activity and albumin/creatinine ratio rather than elevated concentrations of individual proteins., [RefSeq, PubMed]; Studies indicate the most studied biomarkers for acute kidney injury are neutrophil gelatinase-associated lipocalin-2, kidney injury molecule-1, IL-18, cystatin C, N-acetyl-beta-D-glucosaminidase, liver fatty-acid binding protein, and heat shock protein 72. Review article, [RefSeq, PubMed]; The catalytically important residues are Asp148 and Glu149, with Glu149 serving as the general acid/base residue and Asp148 as the polarizing residue. HexD is inhibited by Gal-NAG-thiazoline (Ki = 420 nM)., [RefSeq, PubMed]; The expression and disease relevance of the HEXDC gene in humans demonstrate the expression of this novel enzyme within the joints, and suggests that its activity may significantly contribute to the overall local exoglycosidase activity., [RefSeq, PubMed]; The results suggest that, following coronary angiography and/or percutaneous coronary intervention, contrast-induced nephropathy (CIN) occurs to a certain degree and that NAG may be a useful early CIN marker., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 612,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7UUP6;Q8IYN4;Q8TE81",
        "ec_number_list": [],
        "go_molecular_function": "GO:0015929 hexosaminidase activity;GO:0004563 beta-N-acetylhexosaminidase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:1903561 extracellular vesicle",
        "go_biological_process": "GO:0005975 carbohydrate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q8WVB3-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000001000.001.10100",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NZC7-1",
        "uniprot_id": [
            {
                "id": "WWOX_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZC7",
                "type": "external"
            }
        ],
        "mass": 46677.0,
        "length": 414,
        "protein_name": "WW domain-containing oxidoreductase",
        "gene_name": "WWOX",
        "organism": "Human",
        "refseq_name": "WW domain-containing oxidoreductase isoform 4",
        "refseq_ac": [
            {
                "id": "NP_001278926",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278926",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "WWOX; FOR; SDR41C1; WOX1",
        "gene_names_refseq": "D16S432E; DEE28; EIEE28; FOR; FRA16D; HHCMA56; PRO0128; SCAR12; SDR41C1; WOX1; WWOX",
        "protein_names_uniprotkb": "WW domain-containing oxidoreductase; 1.1.1.-; Fragile site FRA16D oxidoreductase; Short chain dehydrogenase/reductase family 41C member 1",
        "protein_names_refseq": "WW domain-containing oxidoreductase isoform 4; WW domain-containing protein WWOX; fragile site FRA16D oxidoreductase; short chain dehydrogenase/reductase family 41C member 1",
        "tax_id": 9606,
        "disease": "autosomal recessive spinocerebellar ataxia 12 (Disease Ontology:DOID:0080060); developmental and epileptic encephalopathy 28 (Disease Ontology:DOID:0080452); Leber congenital amaurosis (Disease Ontology:DOID:14791); cancer (Disease Ontology:DOID:162); squamous cell carcinoma (Disease Ontology:DOID:1749); epilepsy (Disease Ontology:DOID:1826); esophagus squamous cell carcinoma (Disease Ontology:DOID:3748); esophageal cancer (Disease Ontology:DOID:5041)",
        "pathway": " (hsa:51741);  (R-HSA-1251985);  (R-HSA-8866904);  (R-HSA-8866907)",
        "pathway_count": 4,
        "publication_count": 97,
        "publication_id_list": "10786676;10861292;11237011;11572989;11679632;11694877;11719429;11744733;11956080;12514174;12586840;12807903;14555208;14695174;15023535;15064722;15070730;15073125;15131042;15266310;15345747;15534001;15548692;15580310;16061658;16219768;16223882;16288044;16698963;16912174;17018285;17567906;18371080;18653779;19047365;19115315;19366691;19465938;19484134;19596786;19690332;1998122;2010091;20432460;22226915;22534828;23230144;23382213;24008736;24308844;24369382;24456803;24715725;24829397;24899407;25411445;25418920;25649963;26120275;26592150;26992070;27339895;28218747;28228285;28834231;28904123;29310447;29437277;29557506;30154439;30285739;30315122;30410026;30429286;30524438;31217245;31844290;32265295;32357974;32387766;32502341;32897882;32938616;33141586;33298915;33691108;33936100;33968037;34171305;34357683;34509645;35051231;36215666;37615513;37897534;37974179;38203337",
        "class_list": "",
        "function": "Identification of compound heterozygous deletion of the WWOX gene in WOREE syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Loss of fragile WWOX gene leads to senescence escape and genome instability. Publication Status: Online-Only, [RefSeq, PubMed]; Mechanistic Investigation of WWOX Function in NF-kB-Induced Skin Inflammation in Psoriasis. Publication Status: Online-Only, [RefSeq, PubMed]; Putative oxidoreductase. Acts as a tumor suppressor and plays a role in apoptosis. Required for normal bone development (By similarity). May function synergistically with p53/TP53 to control genotoxic stress-induced cell death. Plays a role in TGFB1 signaling and TGFB1-mediated cell death. May also play a role in tumor necrosis factor (TNF)-mediated cell death. Inhibits Wnt signaling, probably by sequestering DVL2 in the cytoplasm., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Remote modulation of WWOX by an intronic variant associated with survival of Chinese gastric cancer patients., [RefSeq, PubMed]; This gene encodes a member of the short-chain dehydrogenases/reductases (SDR) protein family. This gene spans the FRA16D common chromosomal fragile site and appears to function as a tumor suppressor gene. Expression of the encoded protein is able to induce apoptosis, while defects in this gene are associated with multiple types of cancer. Disruption of this gene is also associated with autosomal recessive spinocerebellar ataxia 12. Disruption of a similar gene in mouse results in impaired steroidogenesis, additionally suggesting a metabolic function for the protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]., [RefSeq]; WWOX, the FRA16D gene, behaves as a suppressor of tumor growth., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K323;Q5MYT5;Q96KM3;Q96RF2;Q9BTT8;Q9NPC9;Q9NRF4;Q9NRF5;Q9NRF6;Q9NRK1;Q9NZC5",
        "ec_number_list": [
            {
                "id": "1.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006915 apoptotic process;GO:2001238 positive regulation of extrinsic apoptotic signaling pathway;GO:0016055 Wnt signaling pathway;GO:0071560 cellular response to transforming growth factor beta stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 9.8,
        "record_id": "Q9NZC7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P17096-1",
        "uniprot_id": [
            {
                "id": "HMGA1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P17096",
                "type": "external"
            }
        ],
        "mass": 11676.0,
        "length": 107,
        "protein_name": "High mobility group protein HMG-I/HMG-Y",
        "gene_name": "HMGA1",
        "organism": "Human",
        "refseq_name": "high mobility group protein HMG-I/HMG-Y isoform b",
        "refseq_ac": [
            {
                "id": "NP_001306006",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001306006",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HMGA1; HMGIY",
        "gene_names_refseq": "HMG-R; HMGA1A; HMGA1; HMGIY",
        "protein_names_uniprotkb": "High mobility group protein HMG-I/HMG-Y; HMG-I(Y); High mobility group AT-hook protein 1; High mobility group protein A1; High mobility group protein R",
        "protein_names_refseq": "high mobility group protein A1; high mobility group protein HMG-I/HMG-Y isoform b; high mobility group protein HMG-I/HMG-Y; high mobility group protein R; nonhistone chromosomal high-mobility group protein HMG-I/HMG-Y",
        "tax_id": 9606,
        "disease": "lymphoma (Disease Ontology:DOID:0060058); uterine cancer (Disease Ontology:DOID:363); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:3159);  (R-HSA-162592);  (R-HSA-164843);  (R-HSA-175567);  (R-HSA-177539);  (R-HSA-180689);  (R-HSA-180910);  (R-HSA-2559584)",
        "pathway_count": 8,
        "publication_count": 104,
        "publication_id_list": "10428834;10617144;11237011;11593421;11978964;12228227;12653562;12808465;14729942;15098018;15479846;15621527;15655109;15731250;15835918;16157300;16159886;16175173;16291214;16901784;1692833;17081983;17158953;17242198;17242207;17525332;17924679;17960875;18318008;18452278;18491316;18669648;19029251;19367720;1939057;19413330;19415658;19608861;19651622;19664995;19690332;20068230;20068231;20166139;20187088;21406692;2171144;21807893;23186163;23964094;24275569;2505228;2539592;25576301;25586095;26552660;26758079;2701943;2806554;28190768;28290473;28832583;2920035;29242379;29508533;29557506;29789417;3032450;30444036;30833945;31340016;31611695;31717259;31844290;32157095;32350084;32488085;32938616;32983136;33141586;33214551;33968037;34019948;34561969;35008409;35051231;35154160;35251023;35561310;35580925;35864955;3619901;36284347;37217939;38922788;39134516;8414980;8883604;9038339;9188609;9253416;9436978;9582382;9860958",
        "class_list": "",
        "function": "HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HMGA1 orchestrates chromatin compartmentalization and sequesters genes into 3D networks coordinating senescence heterogeneity. Publication Status: Online-Only, [RefSeq, PubMed]; High Mobility Group A1 (HMGA1): Structure, Biological Function, and Therapeutic Potential. Review article Publication Status: Online-Only, [RefSeq, PubMed]; NAT10 Promotes Prostate Cancer Growth and Metastasis by Acetylating mRNAs of HMGA1 and KRT8., [RefSeq, PubMed]; This gene encodes a chromatin-associated protein involved in the regulation of gene transcription, integration of retroviruses into chromosomes, and the metastatic progression of cancer cells. The encoded protein preferentially binds to the minor groove of AT-rich regions in double-stranded DNA. Multiple transcript variants encoding different isoforms have been found for this gene. Pseudogenes of this gene have been identified on multiple chromosomes. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 26,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "diagnostic",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P10910;Q5T6U9;Q9UKB0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051575 5'-deoxyribose-5-phosphate lyase activity;GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0008301 DNA binding, bending;GO:0060090 molecular adaptor activity;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005925 focal adhesion;GO:0031965 nuclear membrane",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0008285 negative regulation of cell population proliferation;GO:0035556 intracellular signal transduction;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006284 base-excision repair",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "P17096-1",
        "record_type": "protein",
        "filter_code": "1000000.0100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q93063-1",
        "uniprot_id": [
            {
                "id": "EXT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q93063",
                "type": "external"
            }
        ],
        "mass": 82255.0,
        "length": 718,
        "protein_name": "Exostosin-2",
        "gene_name": "EXT2",
        "organism": "Human",
        "refseq_name": "exostosin-2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000392",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000392",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EXT2",
        "gene_names_refseq": "EXT2; SOTV; SSMS",
        "protein_names_uniprotkb": "Exostosin-2; 2.4.1.224; Exostosin glycosyltransferase 2; Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Heparan sulfate co-polymerase subunit EXT1; Multiple exostoses protein 2",
        "protein_names_refseq": "N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase; exostosin-2 isoform 1; exostosin-2; glucuronosyl-N-acetylglucosaminyl-proteoglycan/N- acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; heparan sulfate co-polymerase subunit EXT1; multiple exostoses protein 2; multiple exostosis 2; putative tumor suppressor protein EXT2",
        "tax_id": 9606,
        "disease": "Potocki-Shaffer syndrome (Disease Ontology:DOID:0111687); hereditary multiple exostoses (Disease Ontology:DOID:206); hereditary multiple osteochondromas (MONDO:MONDO:0005508); seizures-scoliosis-macrocephaly syndrome (MONDO:MONDO:0014731)",
        "pathway": " (hsa:2132);  (R-HSA-2022928);  (R-HSA-3656237);  (R-HSA-3656253)",
        "pathway_count": 4,
        "publication_count": 145,
        "publication_id_list": "10.1101/2023.09.13.557529;10318803;10429361;10480354;10545594;10639137;10644753;10677367;10679296;10679937;10716625;10738008;11087757;11169766;11170095;11237011;11274177;11279150;11390981;11391482;11432960;11668521;12138164;12492399;15082721;15607426;16343444;18337501;19344451;20554947;21700882;22544926;22660413;23090970;23481700;24190977;24714562;25548167;25576301;25645385;25802875;25892735;26154972;26246518;26375851;26728094;26992070;27600516;27846572;27862975;27920218;28132690;28148688;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30075207;30288735;30315122;30410026;30429286;30471091;30524438;30573663;30779550;30806661;30833945;30997052;31154438;31222486;31611695;31844290;31848261;31937595;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33159882;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34357683;34405274;34509645;35051231;35193931;35251023;35318648;35580925;35676258;36010968;36215666;36241641;36284347;36402845;36593275;37938771;37989698;38155009;6496574;7550340;7601448;7711731;8782816;8894688;8981950;9110175;9326317;9346953;9463333;9535912;9620772;9915799;9988767",
        "class_list": "glycogene;glycosyltransferase",
        "function": "EXT2: a novel prognostic and predictive biomarker for head and neck squamous cell carcinoma., [RefSeq, PubMed]; Exostoisns (EXT1/2) in Head and Neck Cancers: An In Silico Analysis and Clinical Correlates., [RefSeq, PubMed]; Glycosyltransferase forming with EXT1 the heterodimeric heparan sulfate polymerase which catalyzes the elongation of the heparan sulfate glycan backbone (PubMed:22660413, PubMed:36402845, PubMed:36593275). Glycan backbone extension consists in the alternating transfer of (1->4)-beta-D-GlcA and (1->4)-alpha-D-GlcNAc residues from their respective UDP-sugar donors. Both EXT1 and EXT2 are required for the full activity of the polymerase since EXT1 bears the N-acetylglucosaminyl-proteoglycan 4-beta-glucuronosyltransferase activity within the complex while EXT2 carries the glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity (PubMed:36402845, PubMed:36593275). Heparan sulfate proteoglycans are ubiquitous components of the extracellular matrix and play an important role in tissue homeostasis and signaling (PubMed:19344451, PubMed:22660413)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; This gene encodes one of two glycosyltransferases involved in the chain elongation step of heparan sulfate biosynthesis. Mutations in this gene cause the type II form of multiple exostoses. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 1329,
        "reported_interactions": 0,
        "missing_score": 9562,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 4,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5Z6;C9JU51;J3KPT2;O15288",
        "ec_number_list": [
            {
                "id": "2.4.1.225",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.225",
                "type": "external"
            },
            {
                "id": "2.4.1.224",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.224",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0046982 protein heterodimerization activity;GO:0016757 glycosyltransferase activity;GO:0015020 glucuronosyltransferase activity;GO:0042328 heparan sulfate N-acetylglucosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0000271 polysaccharide biosynthetic process;GO:0001503 ossification;GO:0006024 glycosaminoglycan biosynthetic process;GO:0015012 heparan sulfate proteoglycan biosynthetic process;GO:0009101 glycoprotein biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 15.0,
        "record_id": "Q93063-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000000000.100.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96HZ4-1",
        "uniprot_id": [
            {
                "id": "HES6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96HZ4",
                "type": "external"
            }
        ],
        "mass": 24129.0,
        "length": 224,
        "protein_name": "Transcription cofactor HES-6",
        "gene_name": "HES6",
        "organism": "Human",
        "refseq_name": "transcription cofactor HES-6 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001136325",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136325",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HES6; BHLHB41",
        "gene_names_refseq": "C-HAIRY1; HES-6; HES6; bHLHb41; bHLHc23",
        "protein_names_uniprotkb": "Transcription cofactor HES-6; C-HAIRY1; Class B basic helix-loop-helix protein 41; Hairy and enhancer of split 6; bHLHb41",
        "protein_names_refseq": "class B basic helix-loop-helix protein 41; hairy and enhancer of split 6; transcription cofactor HES-6 isoform b; transcription cofactor HES-6",
        "tax_id": 9606,
        "disease": "coronary artery disease (Disease Ontology:DOID:3393)",
        "pathway": " (hsa:55502)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "10851137;11044617;11237011;12957362;12972610;26992070;27600516;27920218;28904123;29393594;31844290;32157095;32387766;32897882;32938616;32983136;33141586;33392160;33462406;34509645;35051231;35934844;36010968;36929421;39005046",
        "class_list": "",
        "function": "Differentially expressed in metastatic colon carcinoma, [RefSeq, PubMed]; Does not bind DNA itself but suppresses both HES1-mediated N box-dependent transcriptional repression and binding of HES1 to E box sequences. Also suppresses HES1-mediated inhibition of the heterodimer formed by ASCL1/MASH1 and TCF3/E47, allowing ASCL1 and TCF3 to up-regulate transcription in its presence. Promotes cell differentiation (By similarity)., [UniProtKB]; ERCC5, HES6 and RORA are potential diagnostic markers of coronary artery disease., [RefSeq, PubMed]; HES6 Mediates Oxidative Phosphorylation Pathway to Promote Immune Infiltration of CD8 + T Cells in Lung Adenocarcinoma., [RefSeq, PubMed]; Hes6 promotes cortical neurogenesis and inhibits Hes1 transcription repression activity., [RefSeq, PubMed]; Single-cell RNA sequencing reveals intratumoral heterogeneity in primary uveal melanomas and identifies HES6 as a driver of the metastatic disease., [RefSeq, PubMed]; The novel GATA1-interacting protein HES6 is an essential transcriptional cofactor for human erythropoiesis., [RefSeq, PubMed]; This gene encodes a member of a subfamily of basic helix-loop-helix transcription repressors that have homology to the Drosophila enhancer of split genes. Members of this gene family regulate cell differentiation in numerous cell types. The protein encoded by this gene functions as a cofactor, interacting with other transcription factors through a tetrapeptide domain in its C-terminus. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Dec 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KAP6;B8ZZA9;Q53SN9;Q8N2J2;Q96T93;Q9P2S3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0009952 anterior/posterior pattern specification",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q96HZ4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P42701-1",
        "uniprot_id": [
            {
                "id": "I12R1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P42701",
                "type": "external"
            }
        ],
        "mass": 73109.0,
        "length": 662,
        "protein_name": "Interleukin-12 receptor subunit beta-1",
        "gene_name": "IL12RB1",
        "organism": "Human",
        "refseq_name": "interleukin-12 receptor subunit beta-1 isoform 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_001276952",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276952",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL12RB1; IL12RB; IL12R",
        "gene_names_refseq": "CD212; IL-12R-BETA1; IL12RB1; IL12RB; IMD30",
        "protein_names_uniprotkb": "Interleukin-12 receptor subunit beta-1; IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; IL-12R-beta-1; IL-12RB1",
        "protein_names_refseq": "IL-12 receptor beta component; IL-12 receptor subunit beta-1; IL-12R subunit beta-1; cluster of differentiation 212; interleukin 12 receptor, beta 1; interleukin-12 receptor beta-1 chain; interleukin-12 receptor subunit beta-1 isoform 3 precursor",
        "tax_id": 9606,
        "disease": "immunodeficiency 30 (Disease Ontology:DOID:0111990); primary biliary cholangitis (Disease Ontology:DOID:12236); asthma (Disease Ontology:DOID:2841); severe acute respiratory syndrome (Disease Ontology:DOID:2945); pulmonary tuberculosis (Disease Ontology:DOID:2957); tuberculosis (Disease Ontology:DOID:399); allergic rhinitis (Disease Ontology:DOID:4481)",
        "pathway": " (hsa:3594);  (R-HSA-9020591);  (R-HSA-9020933)",
        "pathway_count": 3,
        "publication_count": 56,
        "publication_id_list": "10415122;10899108;11054122;11114383;11237011;11424023;12023369;12893768;12947981;1347984;15004198;15087447;15720785;1578138;16138901;1674604;18389480;18840671;19161421;19531498;20054003;20699468;24366607;25259790;25516297;26109132;26887945;26972013;27920218;28228285;28832583;28904123;29493099;29557506;31530632;31844290;31848261;32350084;32387766;32502341;32983136;33717175;33912179;33968037;34357683;34438084;35051231;35580925;36007427;38317798;7527811;7638186;7911493;8943050;9498755;9890938",
        "class_list": "",
        "function": "Discovering the link between IL12RB1 gene polymorphisms and tuberculosis susceptibility: a comprehensive meta-analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as an interleukin receptor which binds interleukin-12 with low affinity and is involved in IL12 transduction. Associated with IL12RB2 it forms a functional, high affinity receptor for IL12. Also associates with IL23R to form the interleukin-23 receptor which functions in IL23 signal transduction probably through activation of the Jak-Stat signaling cascade., [UniProtKB, PubMed]; IL12RB1 allele bias in human TH cells is regulated by functional SNPs in its 3'UTR., [RefSeq, PubMed]; Novel IL-12Rbeta1 deficiency-mediates recurrent cutaneous leishmaniasis., [RefSeq, PubMed]; The protein encoded by this gene is a type I transmembrane protein that belongs to the hemopoietin receptor superfamily. This protein binds to interleukine 12 (IL12) with a low affinity, and is thought to be a part of IL12 receptor complex. This protein forms a disulfide-linked oligomer, which is required for its IL12 binding activity. The coexpression of this and IL12RB2 proteins was shown to lead to the formation of high-affinity IL12 binding sites and reconstitution of IL12 dependent signaling. Mutations in this gene impair the development of interleukin-17-producing T lymphocytes and result in increased susceptibility to mycobacterial and Salmonella infections. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2014]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 7,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K308;B2RPF1;B7ZKK3;Q8N6Q7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0015026 coreceptor activity;GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity;GO:0016517 interleukin-12 receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0042022 interleukin-12 receptor complex;GO:0072536 interleukin-23 receptor complex",
        "go_biological_process": "GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0035722 interleukin-12-mediated signaling pathway;GO:0001916 positive regulation of T cell mediated cytotoxicity;GO:0002230 positive regulation of defense response to virus by host",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "P42701-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NYF5-1",
        "uniprot_id": [
            {
                "id": "FA13B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NYF5",
                "type": "external"
            }
        ],
        "mass": 104543.0,
        "length": 915,
        "protein_name": "Protein FAM13B",
        "gene_name": "FAM13B",
        "organism": "Human",
        "refseq_name": "protein FAM13B isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001095270",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095270",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM13B; C5orf5; FAM13B1",
        "gene_names_refseq": "ARHGAP49; C5orf5; FAM13B1; FAM13B; KHCHP; N61",
        "protein_names_uniprotkb": "Protein FAM13B; GAP-like protein N61",
        "protein_names_refseq": "GAP-like protein N61; family with sequence similarity 13, member B1; protein FAM13B isoform 2; protein FAM13B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51306);  (R-HSA-9013148);  (R-HSA-9013149)",
        "pathway_count": 3,
        "publication_count": 281,
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        "function": "FAM167A is a key molecule to induce BCR-ABL-independent TKI resistance in CML via noncanonical NF-kappaB signaling activation. Publication Status: Online-Only, [RefSeq, PubMed]; Identified and confirmed through replication two new genetic loci for SLE: a promoter-region allele associated with reduced expression of BLK and increased expression of C8orf13 and variants in the ITGAM-ITGAX region, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Results indicate the FAM167A-BLK region may be a shared genetic factor for a number of autoimmune diseases in multiple populations, but the genetic contribution may be grater in Asian populations. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
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        "protein_names_refseq": "aminolevulinate, delta-, dehydratase; delta-aminolevulinic acid dehydratase isoform b; delta-aminolevulinic acid dehydratase; porphobilinogen synthase; testicular tissue protein Li 95",
        "tax_id": 9606,
        "disease": "hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); hemochromatosis (Disease Ontology:DOID:2352); anemia (Disease Ontology:DOID:2355); acute kidney failure (Disease Ontology:DOID:3021); porphyria cutanea tarda (Disease Ontology:DOID:3132); acute porphyria (Disease Ontology:DOID:3133); liver cirrhosis (Disease Ontology:DOID:5082)",
        "pathway": " (hsa:210);  (R-HSA-189451);  (R-HSA-6798695)",
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        "go_molecular_function": "GO:0032791 lead ion binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0003824 catalytic activity;GO:0004655 porphobilinogen synthase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005829 cytosol;GO:0034774 secretory granule lumen;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0046685 response to arsenic-containing substance;GO:0006979 response to oxidative stress;GO:0010043 response to zinc ion;GO:0032496 response to lipopolysaccharide;GO:0045471 response to ethanol",
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    {
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        "length": 414,
        "protein_name": "Isocitrate dehydrogenase [NADP] cytoplasmic",
        "gene_name": "IDH1",
        "organism": "Human",
        "refseq_name": "isocitrate dehydrogenase [NADP] cytoplasmic",
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269315",
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        "gene_names_uniprotkb": "IDH1; PICD",
        "gene_names_refseq": "HEL-216; HEL-S-26; IDCD; IDH1; IDH; IDPC; IDP; PICD",
        "protein_names_uniprotkb": "Isocitrate dehydrogenase [NADP] cytoplasmic; 1.1.1.42; Cytosolic NADP-isocitrate dehydrogenase; IDH1; IDH; IDPc; NADP(+)-specific ICDH; Oxalosuccinate decarboxylase",
        "protein_names_refseq": "NADP(+)-specific ICDH; NADP-dependent isocitrate dehydrogenase, cytosolic; NADP-dependent isocitrate dehydrogenase, peroxisomal; epididymis luminal protein 216; epididymis secretory protein Li 26; epididymis secretory sperm binding protein; isocitrate dehydrogenase (NADP(+)) 1, cytosolic; isocitrate dehydrogenase 1 (NADP+), soluble; isocitrate dehydrogenase [NADP] cytoplasmic; oxalosuccinate decarboxylase",
        "tax_id": 9606,
        "disease": "D-2-hydroxyglutaric aciduria (Disease Ontology:DOID:0050575); myelodysplastic syndrome (Disease Ontology:DOID:0050908); cancer (Disease Ontology:DOID:162); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); autoimmune disease (Disease Ontology:DOID:417); intrahepatic cholangiocarcinoma (Disease Ontology:DOID:4928); hepatocellular clear cell carcinoma (Disease Ontology:DOID:5016); acute myeloid leukemia (Disease Ontology:DOID:9119)",
        "pathway": " (hsa:3417);  (R-HSA-2978092);  (R-HSA-389542);  (R-HSA-6798695);  (R-HSA-9033241);  (R-HSA-9818025)",
        "pathway_count": 6,
        "publication_count": 246,
        "publication_id_list": "10.1101/2023.09.13.557529;10022913;10521434;10562279;10673331;11083877;11101887;11230166;11237011;11546814;11781871;11931631;12234984;12456682;12559034;12578380;12717447;12885776;15173171;15545321;15858711;16407072;16408927;16854980;16959974;17007944;17726030;18359941;18712838;18772396;19117336;19197237;19208625;19340432;1946430;19554337;19584060;19608861;19632994;19818334;19903171;19935646;20068231;20077503;20178365;20560678;21213123;21344322;21352804;21494763;21516462;21539821;21554508;21575384;21760534;21775727;21976670;21980954;22002062;22033490;22057399;22113362;22136423;22172803;22197544;22371489;22385787;22445362;22447191;22747494;22772980;22789539;23011765;23041832;23111200;23141938;23223340;23257422;23486690;23527265;23588371;23619925;23650620;23801081;23840696;23934175;23934769;23963456;24077277;24235149;24242757;24252742;24275569;24384677;24473683;24511544;24590270;24616312;24668804;24805856;24865970;24868540;24895549;25005896;25016021;25043048;25271760;25407774;25418920;25427834;25496513;25538232;25567591;25576301;25645385;25810538;25854684;25960387;26086376;26138649;26154972;26161668;26189213;26190195;26220973;26344566;26374642;26485760;26617931;26743027;26853435;26860959;26918938;26927556;26992070;27097804;27155448;27300198;27452731;27553586;27597759;27600516;27621679;27655638;27846572;27904447;27920218;27993946;28002956;28201752;28218747;28419269;28427200;28445981;28510447;28514659;28521612;28611990;28667042;28765278;28787099;28832583;28834231;28873367;28904123;29016947;29242379;29437277;29453678;29497819;29508533;29557506;29625108;29632046;29632711;29728520;29743236;29786170;29789417;29859360;30315122;30410026;30429286;30779550;30833945;31221981;31844290;31848261;31989830;32157095;32284348;32350084;32387766;32488085;32502341;32582032;32649885;32897882;32938616;32983136;33043033;33064660;33123756;33141586;33214551;33537174;33592498;33968037;33981976;34105348;34171305;34211107;34229054;34509645;34561969;34725712;35051231;35138101;35251023;35580925;36215666;36241641;37938771;38665916;38760850;38827324;38842680;38991060;39318042;39894887;40914422;7719337;7790377;8041788;8692836;8824437;8858165;8991089;9090381;9090382;9090383;9539740;9653144;9668159;9837948;9866202",
        "class_list": "",
        "function": "Catalyzes the NADP(+)-dependent oxidative decarboxylation of isocitrate (D-threo-isocitrate) to 2-ketoglutarate (2-oxoglutarate), which is required by other enzymes such as the phytanoyl-CoA dioxygenase (PubMed:10521434, PubMed:19935646). Plays a critical role in the generation of NADPH, an important cofactor in many biosynthesis pathways (PubMed:10521434). May act as a corneal epithelial crystallin and may be involved in maintaining corneal epithelial transparency (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Differential isocitrate dehydrogenase 1 and isocitrate dehydrogenase 2 mutation-related landscape in intrahepatic cholangiocarcinoma., [RefSeq, PubMed]; Gaining Insight into the Catalytic Mechanism of the R132H IDH1 Mutant: A Synergistic DFT Cluster and Experimental Investigation., [RefSeq, PubMed]; IDH1 mutation produces R-2-hydroxyglutarate (R-2HG) and induces mir-182-5p expression to regulate cell cycle and tumor formation in glioma. Publication Status: Online-Only, [RefSeq, PubMed]; Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Five isocitrate dehydrogenases have been reported: three NAD(+)-dependent isocitrate dehydrogenases, which localize to the mitochondrial matrix, and two NADP(+)-dependent isocitrate dehydrogenases, one of which is mitochondrial and the other predominantly cytosolic. Each NADP(+)-dependent isozyme is a homodimer. The protein encoded by this gene is the NADP(+)-dependent isocitrate dehydrogenase found in the cytoplasm and peroxisomes. It contains the PTS-1 peroxisomal targeting signal sequence. The presence of this enzyme in peroxisomes suggests roles in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic enzyme serves a significant role in cytoplasmic NADPH production. Alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Sep 2013]., [RefSeq]; Mutant IDH1 inhibition induces dsDNA sensing to activate tumor immunity., [RefSeq, PubMed]; The interplay mechanism between IDH mutation, MGMT-promoter methylation, and PRMT5 activity in the progression of grade 4 astrocytoma: unraveling the complex triad theory. Publication Status: Online-Only, [RefSeq, PubMed]",
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        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005777 peroxisome;GO:0005782 peroxisomal matrix",
        "go_biological_process": "GO:0006739 NADP+ metabolic process;GO:0006099 tricarboxylic acid cycle;GO:0006102 isocitrate metabolic process;GO:0006103 2-oxoglutarate metabolic process;GO:0048545 response to steroid hormone",
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    {
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        "protein_name": "Parathyroid hormone 2 receptor",
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        "protein_names_uniprotkb": "Parathyroid hormone 2 receptor; PTH2 receptor",
        "protein_names_refseq": "PTH2 receptor; parathyroid hormone 2 receptor isoform 2; parathyroid hormone receptor 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5746);  (R-HSA-373080);  (R-HSA-418555)",
        "pathway_count": 3,
        "publication_count": 84,
        "publication_id_list": "10097073;11007482;11237011;11297558;11861531;12036966;12058044;12098667;12106601;12180353;12559132;12860470;13549488;14671004;1517224;15498814;15765929;15769620;15951850;16313925;16602827;16687412;16923326;17168849;18044684;18491316;18577758;18801728;19105585;19876791;19929708;20381629;20966082;21036126;2163110;2417744;24687066;2491850;2553411;2553705;26417854;27000502;28094886;2871555;29443750;29557506;29602314;30001391;30833991;3127824;31279028;31399091;31983287;32226383;32488085;32497535;32540603;32618402;32715661;33049737;34353904;35051231;35494241;3616618;6085243;6950381;7797535;8082781;8198617;8340388;8386612;8397094;8514797;8557170;8612563;8672451;8732687;8770894;8906787;8921382;9064337;9263355;9417641;9651336",
        "class_list": "",
        "function": "Expressed in the epidermis in Darier disease, [RefSeq, PubMed]; Molecular insights into differentiated ligand recognition of the human parathyroid hormone receptor 2., [RefSeq, PubMed]; PTH2R and its ligand TIP39 regulate intracellular calcium and influence keratinocyte differentiation, [RefSeq, PubMed]; The protein encoded by this gene is a member of the G-protein coupled receptor 2 family. This protein is a receptor for parathyroid hormone (PTH). This receptor is more selective in ligand recognition and has a more specific tissue distribution compared to parathyroid hormone receptor 1 (PTHR1). It is activated only by PTH and not by parathyroid hormone-like hormone (PTHLH) and is particularly abundant in brain and pancreas. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2013]., [RefSeq]; This is a specific receptor for parathyroid hormone. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. PTH2R may be responsible for PTH effects in a number of physiological systems. It may play a significant role in pancreatic function. PTH2R presence in neurons indicates that it may function as a neurotransmitter receptor (By similarity)., [UniProtKB]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N429",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017046 peptide hormone binding;GO:0008528 G protein-coupled peptide receptor activity;GO:0004991 parathyroid hormone receptor activity;GO:0004930 G protein-coupled receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007188 adenylate cyclase-modulating G protein-coupled receptor signaling pathway;GO:0120162 positive regulation of cold-induced thermogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "P49190-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q71UI9-1",
        "uniprot_id": [
            {
                "id": "H2AV_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q71UI9",
                "type": "external"
            }
        ],
        "mass": 13509.0,
        "length": 128,
        "protein_name": "Histone H2A.V",
        "gene_name": "H2AZ2",
        "organism": "Human",
        "refseq_name": "histone H2A.V isoform 1",
        "refseq_ac": [
            {
                "id": "NP_036544",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036544",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2AZ2; H2AFV; H2AV",
        "gene_names_refseq": "H2A.Z-2; H2AFV; H2AV; H2AZ2",
        "protein_names_uniprotkb": "Histone H2A.V; H2A.F/Z; H2A.Z variant histone 2",
        "protein_names_refseq": "H2A histone family member V; histone H2A.F/Z; histone H2A.V isoform 1; histone H2A.V; purine-rich binding element protein B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:94239);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214858);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-9821002);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962)",
        "pathway_count": 46,
        "publication_count": 908,
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        "class_list": "",
        "function": "A mutational analysis revealed that the amino-acid difference at position 38 is at least partially responsible for the structural polymorphism in the L1 loop region of H2A.Z.1 and H2A.Z.2., [RefSeq, PubMed]; Analysis of histone variant constraint and tissue expression suggests five potential novel human disease genes: H2AFY2, H2AFZ, H2AFY, H2AFV, H1F0., [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. Several transcript variants encoding different isoforms, have been identified for this gene. [provided by RefSeq, Oct 2015]., [RefSeq]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. May be involved in the formation of constitutive heterochromatin. May be required for chromosome segregation during cell division (By similarity)., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NFA8;A6NKY0;A6NN01;A8MQC5;Q59GV8;Q6PK98",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0006325 chromatin organization;GO:0031507 heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 91.1,
        "record_id": "Q71UI9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92802-1",
        "uniprot_id": [
            {
                "id": "N42L2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92802",
                "type": "external"
            }
        ],
        "mass": 67459.0,
        "length": 583,
        "protein_name": "NEDD4-binding protein 2-like 2",
        "gene_name": "N4BP2L2",
        "organism": "Human",
        "refseq_name": "NEDD4-binding protein 2-like 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_055702",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055702",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "N4BP2L2; CG005; PFAAP5",
        "gene_names_refseq": "92M18.3; CG005; CG016; N4BP2L2; PFAAP5",
        "protein_names_uniprotkb": "NEDD4-binding protein 2-like 2; Phosphonoformate immuno-associated protein 5",
        "protein_names_refseq": "NEDD4-binding protein 2-like 2 isoform 2; phosphonoformate immuno-associated protein 5; protein from BRCA2 region",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10443)",
        "pathway_count": 1,
        "publication_count": 58,
        "publication_id_list": "11237011;16344560;17525332;19506020;22424782;23481700;24714562;25418920;25576301;25880248;25892735;26154972;26728094;26992070;27397612;27862975;28063628;28228285;28832583;28834231;28855257;28904123;29242379;29393594;29508533;29557506;29632711;29769354;29786170;30315122;30429286;31217245;31844290;32157095;32265295;32357974;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33717175;33936100;33968037;33981976;34171305;34932366;35051231;35318648;35561310;35580925;36010968;36284347;36581221;39894887;8812419",
        "class_list": "",
        "function": "Data suggest that expression of PFAAP5 allows neutrophil elastase to potentiate the repression of Gfi1 target genes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
        "glycan_count": 1,
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        "secondary_ac_list": "A3KME8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0003714 transcription corepressor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0070062 extracellular exosome;GO:0017053 transcription repressor complex",
        "go_biological_process": "GO:1902037 negative regulation of hematopoietic stem cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:1902035 positive regulation of hematopoietic stem cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q92802-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96C01-1",
        "uniprot_id": [
            {
                "id": "TIMCC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96C01",
                "type": "external"
            }
        ],
        "mass": 15641.0,
        "length": 138,
        "protein_name": "TIM double twin CX3C motif protein",
        "gene_name": "TIMCC",
        "organism": "Human",
        "refseq_name": "protein FAM136A isoform 1",
        "refseq_ac": [
            {
                "id": "NP_116211",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116211",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TIMCC; FAM136A",
        "gene_names_refseq": "FAM136A; TIMCC",
        "protein_names_uniprotkb": "TIM double twin CX3C motif protein",
        "protein_names_refseq": "family with sequence similarity 136 member A; protein FAM136A isoform 1; protein FAM136A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84908)",
        "pathway_count": 1,
        "publication_count": 53,
        "publication_id_list": "11237011;20707881;22869377;23481700;24029068;24714562;24715725;25305078;25418920;25502872;25576301;25645385;25810538;26154972;26375851;26728094;26929215;26992070;27083884;27397612;27600516;27846572;27862975;28510447;28904123;29393594;29493099;29557506;30429286;31844290;32098576;32157095;32265295;32350084;32488085;32502341;32897882;32983136;33141586;33298915;33592498;33968037;34171305;34357683;34561969;34932366;35051231;35580925;36284347;37938771;39821719;40714634;41109133",
        "class_list": "",
        "function": "FAM136A immunoreactivity is associated with nodal involvement and survival in lung adenocarcinoma in a Chinese case series., [RefSeq, PubMed]; Our findings suggest that novel mutations in FAM136A and DTNA genes are probably causal variants in FMD., [RefSeq, PubMed]; Plays a role in proteostasis of the mitochondrion intermembrane space and counteracts aggregation of certain proteins (PubMed:40714634, PubMed:41109133). Required for mitochondrial oxidative phosphorylation (PubMed:40714634)., [UniProtKB, PubMed, PubMed]; This gene encodes a mitochondrially localized protein that is highly conserved across species. The gene is expressed in a variety of tissues including human lymphoblast cells and rat neurosensorial epithelium of the cristaampullaris. A mutation in this gene has been associated with familial Meniere's disease, a chronic disorder of the inner ear. Several pseudogenes of this gene are found on other chromosomes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2016]., [RefSeq]; This study showed that FAM136A genes have been identified in familial Meniere's disease. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "reported_mutagensis": 10,
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        "missing_score": 0,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96SS3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q96C01-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P32019-1",
        "uniprot_id": [
            {
                "id": "I5P2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P32019",
                "type": "external"
            }
        ],
        "mass": 112852.0,
        "length": 993,
        "protein_name": "Type II inositol 1,4,5-trisphosphate 5-phosphatase",
        "gene_name": "INPP5B",
        "organism": "Human",
        "refseq_name": "type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001284363",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284363",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "INPP5B; OCRL2",
        "gene_names_refseq": "5PTase; INPP5B",
        "protein_names_uniprotkb": "Type II inositol 1,4,5-trisphosphate 5-phosphatase; 3.1.3.36; 3.1.3.56; 5PTase; 75 kDa inositol polyphosphate-5-phosphatase; Phosphoinositide 5-phosphatase",
        "protein_names_refseq": "inositol polyphosphate-5-phosphatase, 75kDa; phosphoinositide 5-phosphatase; type II inositol 1,4,5-trisphosphate 5-phosphatase isoform 2 precursor; type II inositol 1,4,5-trisphosphate 5-phosphatase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3633);  (R-HSA-1855183);  (R-HSA-1855204)",
        "pathway_count": 3,
        "publication_count": 99,
        "publication_id_list": "10593988;10866302;11022047;11022048;11042108;11118617;11237011;11909533;12223481;12747803;12890864;1333955;1377913;15024000;15037625;15140260;15316017;15474001;15504367;15579586;15702972;15790568;16107206;1644792;17068342;1718960;17956944;18364358;19179337;20133602;21233288;23481700;24704254;24715725;25305077;2550068;25505266;25869668;25880248;25892735;26154972;26992070;27600516;27846572;28218747;28228285;28411811;2841328;28832583;28834231;28904123;29242379;29437277;29493099;29557506;29769354;30315122;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32897882;32938616;33298915;33592498;33717175;33836029;33912179;34171305;34185709;34357683;34561969;34932366;35051231;35580925;35878408;36010968;36284347;37938771;39302247;7608176;7721860;7761412;7890667;8006039;8390685;8407970;8454637;8530101;8662638;8723348;8769125;9295334;9360711;9430698;9593664",
        "class_list": "",
        "function": "OCRL-mutated fibroblasts from patients with Dent-2 disease exhibit INPP5B-independent phenotypic variability relatively to Lowe syndrome cells, [RefSeq, PubMed]; Regulates phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2) cellular levels by cleaving the phosphate at the 5-position producing PtdIns(4)P. Also hydrolyzes the 5-position phosphate from inositol 1,4,5-trisphosphate (Ins(1,4,5)P3), thereby modulating cellular signaling events., [UniProtKB, PubMed]; The crystal structures of human INPP5B in complex with phosphoinositide substrate analogs revealed a membrane interaction patch likely to assist in sequestering substrates from the lipid bilayer., [RefSeq, PubMed]; The inositol 5-phosphatase INPP5B regulates B cell receptor clustering and signaling., [RefSeq, PubMed]; This gene encodes a member of a family of inositol polyphosphate-5-phosphatases. These enzymes function in the regulation of calcium signaling by inactivating inositol phosphates. The encoded protein is localized to the cytosol and mitochondria, and associates with membranes through an isoprenyl modification near the C-terminus. Alternatively spliced transcript variants of this gene have been described. [provided by RefSeq, Jul 2014]., [RefSeq]",
        "predicted_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "C9J6U5;Q5VSG9;Q5VSH0;Q5VSH1;Q658Q5;Q6P6D4;Q6PD53;Q86YE1",
        "ec_number_list": [
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.95",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95",
                "type": "external"
            },
            {
                "id": "3.1.3.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36",
                "type": "external"
            },
            {
                "id": "3.1.3.64",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64",
                "type": "external"
            },
            {
                "id": "3.1.3.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56",
                "type": "external"
            },
            {
                "id": "3.1.3.86",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0046856 phosphatidylinositol dephosphorylation;GO:0043647 inositol phosphate metabolic process",
        "synthesized_glycan_count": 0,
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        "record_id": "P32019-1",
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        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "F185A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N0U4",
                "type": "external"
            }
        ],
        "mass": 42301.0,
        "length": 392,
        "protein_name": "Protein FAM185A",
        "gene_name": "FAM185A",
        "organism": "Human",
        "refseq_name": "protein FAM185A isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001138740",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138740",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM185A",
        "gene_names_refseq": "FAM185A",
        "protein_names_uniprotkb": "Protein FAM185A",
        "protein_names_refseq": "protein FAM185A isoform 1; protein FAM185A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:222234)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;24715725;28228285;28501589;29557506;30379171;31844290",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "A8MUR7;B4DQD3;C9IZ91",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8N0U4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y5N6-1",
        "uniprot_id": [
            {
                "id": "ORC6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y5N6",
                "type": "external"
            }
        ],
        "mass": 28107.0,
        "length": 252,
        "protein_name": "Origin recognition complex subunit 6",
        "gene_name": "ORC6",
        "organism": "Human",
        "refseq_name": "origin recognition complex subunit 6",
        "refseq_ac": [
            {
                "id": "NP_055136",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055136",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ORC6; ORC6L",
        "gene_names_refseq": "ORC6L; ORC6",
        "protein_names_uniprotkb": "Origin recognition complex subunit 6",
        "protein_names_refseq": "origin recognition complex subunit 6",
        "tax_id": 9606,
        "disease": "Meier-Gorlin syndrome 3 (Disease Ontology:DOID:0080514)",
        "pathway": " (hsa:23594);  (R-HSA-113507);  (R-HSA-176187);  (R-HSA-68616);  (R-HSA-68689);  (R-HSA-68867);  (R-HSA-68949);  (R-HSA-68962)",
        "pathway_count": 8,
        "publication_count": 123,
        "publication_id_list": "10051570;10373362;10373557;10518787;10523313;10757793;10777662;10827953;10846177;10859164;10882098;10884341;11095689;11125146;11237011;11248027;11390642;11562349;11593009;11739726;11931757;12045100;12399544;12578958;12676583;12676925;12759351;12791985;12909626;12963847;14500360;14603323;14605214;14624239;14672932;15190204;15226314;15684404;15707391;15707891;15743907;15833913;16327781;16407120;16549788;16762929;16824194;17081983;17234884;17485488;17525332;17680271;17716973;18452278;18480045;18669648;19413330;19664994;19664995;19896182;20068231;21358632;21502537;21555516;22398447;22405012;22427655;22751019;23186163;23187890;23481700;23603117;23795651;23851460;24003239;25231993;25689043;25762138;25784553;26139588;26222030;26811146;26992070;27249176;28063628;28112645;28832583;28904123;29242379;29393594;29632046;29786170;29899147;30410026;31844290;31848261;31998317;32157095;32265295;32387766;32808929;32848132;33141586;33298899;33298915;33801762;33968037;34131285;34171305;34509645;34561969;37901236;38244670;38867464;38885805;38971772;8196638;8266075;8943031;9278511;9278512;9635433;9660782",
        "class_list": "",
        "function": "A miR-361-5p/ ORC6/ PLK1 axis regulates prostate cancer progression., [RefSeq, PubMed]; Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. The specific DNA sequences that define origins of replication have not been identified yet. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication. Does not bind histone H3 and H4 trimethylation marks H3K9me3, H3K27me3 and H4K20me3., [UniProtKB, PubMed]; Functional studies of the Drosophila homolog, [RefSeq, PubMed]; Functional studies of the yeast homolog, [RefSeq, PubMed]; Long Non-coding RNA COX10-AS1 Promotes Glioma Progression by Competitively Binding miR-1-3p to Regulate ORC6 Expression., [RefSeq, PubMed]; Multi-omics analysis reveals the involvement of origin recognition complex subunit 6 in tumor immune regulation and malignant progression. Publication Status: Online-Only, [RefSeq, PubMed]; Origin recognition complex 6 overexpression promotes growth of glioma cells. Publication Status: Online-Only, [RefSeq, PubMed]; Phosphorylation of Orc6 During Mitosis Regulates DNA Replication and Ribosome Biogenesis., [RefSeq, PubMed]; The origin recognition complex (ORC) is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. Gene silencing studies with small interfering RNA demonstrated that this protein plays an essential role in coordinating chromosome replication and segregation with cytokinesis. [provided by RefSeq, Oct 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 3,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KN89",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0001650 fibrillar center",
        "go_biological_process": "GO:0006270 DNA replication initiation;GO:0006261 DNA-templated DNA replication",
        "synthesized_glycan_count": 0,
        "hit_score": 12.4,
        "record_id": "Q9Y5N6-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9P2P5-1",
        "uniprot_id": [
            {
                "id": "HECW2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9P2P5",
                "type": "external"
            }
        ],
        "mass": 175769.0,
        "length": 1572,
        "protein_name": "E3 ubiquitin-protein ligase HECW2",
        "gene_name": "HECW2",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase HECW2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_065811",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065811",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HECW2; KIAA1301; NEDL2",
        "gene_names_refseq": "HECW2; NDHSAL; NEDL2",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase HECW2; 2.3.2.26; HECT, C2 and WW domain-containing protein 2; HECT-type E3 ubiquitin transferase HECW2; NEDD4-like E3 ubiquitin-protein ligase 2",
        "protein_names_refseq": "E3 ubiquitin-protein ligase HECW2 isoform 1; E3 ubiquitin-protein ligase HECW2; HECT-type E3 ubiquitin transferase HECW2; NEDD4-like E3 ubiquitin-protein ligase 2; NEDD4-related E3 ubiquitin ligase NEDL2",
        "tax_id": 9606,
        "disease": "Liddle syndrome (Disease Ontology:DOID:0050477); neurodevelopmental disorder with hypotonia, seizures, and absent language (MONDO:MONDO:0014995)",
        "pathway": " (hsa:57520);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 64,
        "publication_id_list": "11062501;11237011;11350924;12646216;12890487;14734113;15224091;15224092;15571818;16595681;16849449;16954532;18662542;18669648;19028597;19352404;19413330;19452197;19489725;19651622;19664994;19851334;19874575;19940261;2261476;23186163;24163370;24275569;24715725;25156441;25418920;25469497;26811146;27389779;27846572;27920218;28228285;28904123;29393594;29557506;29632046;30379171;31217245;31844290;32157095;32265295;32350084;32357974;32502341;32938616;33141586;33298915;33633747;33912179;34047014;34321324;34327820;34561969;34767155;35051231;35580925;36010968;9380723;9668046",
        "class_list": "",
        "function": "A novel likely pathogenic heterozygous HECW2 missense variant in a family with variable expressivity of neurodevelopmental delay, hypotonia, and epileptiform EEG patterns., [RefSeq, PubMed]; Circ_0057583 facilitates brain microvascular endothelial cell injury through modulating miR-204-5p/NR4A1 axis., [RefSeq, PubMed]; Delineating the genotypic and phenotypic spectrum of HECW2-related neurodevelopmental disorders. Review article, [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates ubiquitination of TP73. Acts to stabilize TP73 and enhance activation of transcription by TP73 (PubMed:12890487). Involved in the regulation of mitotic metaphase/anaphase transition (PubMed:24163370)., [UniProtKB, PubMed, PubMed]; HECW2-related disorder in four Japanese patients. Erratum:[Am J Med Genet A. 2021 Dec;185(12):3926-3927. doi: 10.1002/ajmg.a.62414. PMID: 34245093], [RefSeq, PubMed]; Low HECW2 expression is associated with cervical cancer., [RefSeq, PubMed]; NEDL2 is a novel substrate of APC/C-Cdh1 as cells exit mitosis and functions as a regulator of the metaphase to anaphase transition, [RefSeq, PubMed]; This gene encodes a member of a family of E3 ubiquitin ligases which plays an important role in the proliferation, migration and differentiation of neural crest cells as a regulator of glial cell line-derived neurotrophic factor (GDNF)/Ret signaling. This gene also plays an important role in angiogenesis through stabilization of endothelial cell-to-cell junctions as a regulator of angiomotin-like 1 stability. The encoded protein contains an N-terminal calcium/lipid-binding (C2) domain involved in membrane targeting, two-four WW domains responsible for cellular localization and substrate recognition, and a C-terminal homologous with E6-associated protein C-terminus (HECT) catalytic domain. Naturally occurring mutations in this gene are associated with neurodevelopmental delay, hypotonia, and epilepsy. The decreased expression of this gene in the aganglionic colon is associated with Hirschsprung's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B8ZZB4;Q17RT5;Q68DF8;Q9NPS9",
        "ec_number_list": [
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0072686 mitotic spindle",
        "go_biological_process": "GO:0048814 regulation of dendrite morphogenesis;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process;GO:0030071 regulation of mitotic metaphase/anaphase transition",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "Q9P2P5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TAG9-1",
        "uniprot_id": [
            {
                "id": "EXOC6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TAG9",
                "type": "external"
            }
        ],
        "mass": 93722.0,
        "length": 804,
        "protein_name": "Exocyst complex component 6",
        "gene_name": "EXOC6",
        "organism": "Human",
        "refseq_name": "exocyst complex component 6 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001013870",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001013870",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EXOC6; SEC15A; SEC15L1; SEC15L",
        "gene_names_refseq": "EXOC6A; EXOC6; SEC15L1; SEC15L3; SEC15L; SEC15; Sec15p",
        "protein_names_uniprotkb": "Exocyst complex component 6; Exocyst complex component Sec15A; SEC15-like protein 1",
        "protein_names_refseq": "SEC15-like 1; SEC15-like protein 3; exocyst complex component 6 isoform b; exocyst complex component Sec15A; rsec15-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54536);  (R-HSA-1445148);  (R-HSA-264876);  (R-HSA-5620916)",
        "pathway_count": 4,
        "publication_count": 136,
        "publication_id_list": "10521251;11237011;11462236;11493706;11707400;11904301;12221131;14617756;14704853;15158452;1528899;15292201;15331542;15728366;15878854;15919790;15971998;16038802;16136078;16155582;16158220;16158222;16213214;16407158;16431365;16478783;16537653;16714477;16782012;16880201;16984975;17007872;17030804;17369524;17574030;17628206;17646400;17956946;17995453;18685082;19013499;19017632;19153612;19252894;19297529;19454479;20083215;20308425;20308558;20631154;20701589;20837646;20937701;21091435;21145486;21273506;21308844;21454505;21454690;21550243;21565611;21713314;21775626;21907143;22389062;22420621;22433857;22983554;23351793;23481700;23567335;23945166;24296415;24366607;24714562;24715725;25091901;2550440;25576301;25880248;26154972;26375851;2669954;26728094;26811146;26992070;2822027;28904123;29242379;29393594;29557506;30429286;30779550;30833945;31154438;31184304;31530632;31844290;31848261;31998317;32157095;32357974;32387766;32488085;32502341;32723473;32938616;32983136;33298915;33485965;33537174;33592498;33691108;33717175;33912179;33968037;34087483;34171305;34185709;34509645;35051231;35494241;35580925;36010968;36215666;36241641;36284347;3896518;7626024;8094051;8664345;8916141;9166668;9207799;9631292;9819391",
        "class_list": "",
        "function": "Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. Together with RAB11A, RAB3IP, RAB8A, PARD3, PRKCI, ANXA2, CDC42 and DNMBP promotes transcytosis of PODXL to the apical membrane initiation sites (AMIS), apical surface formation and lumenogenesis (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Sec15 has a role as an effector for the Rab11 GTPase in mammalian cells, [RefSeq, PubMed]; The SEC15 protein plays a crucial role in integrating the signals between Sec4p and the components of the early-polarity-establishment machinery., [RefSeq, PubMed]; The protein encoded by this gene is highly similar to the Saccharomyces cerevisiae SEC15 gene product, which is essential for vesicular traffic from the Golgi apparatus to the cell surface in yeast. It is one of the components of a multiprotein complex required for exocytosis. The 5' portion of this gene and two neighboring cytochrome p450 genes are included in a deletion that results in an autosomal-dominant form of nonsyndromic optic nerve aplasia (ONA). Alternative splicing and the use of alternative promoters results in multiple transcript variants. A paralogous gene encoding a similar protein is present on chromosome 2. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "E9PHI3;Q5VXH8;Q9NZ24",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030426 growth cone;GO:0048471 perinuclear region of cytoplasm;GO:0090543 Flemming body",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0000281 mitotic cytokinesis;GO:0006887 exocytosis;GO:0006893 Golgi to plasma membrane transport;GO:0090148 membrane fission",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "Q8TAG9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14626-1",
        "uniprot_id": [
            {
                "id": "I11RA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14626",
                "type": "external"
            }
        ],
        "mass": 45222.0,
        "length": 422,
        "protein_name": "Interleukin-11 receptor subunit alpha",
        "gene_name": "IL11RA",
        "organism": "Human",
        "refseq_name": "interleukin-11 receptor subunit alpha precursor",
        "refseq_ac": [
            {
                "id": "NP_001136256",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136256",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL11RA",
        "gene_names_refseq": "CRSDA; IL11RA",
        "protein_names_uniprotkb": "Interleukin-11 receptor subunit alpha; IL-11 receptor subunit alpha; IL-11R subunit alpha; IL-11R-alpha; IL-11RA",
        "protein_names_refseq": "IL-11 receptor subunit alpha; IL-11R subunit alpha; interleukin 11 receptor, alpha; interleukin-11 receptor alpha chain; interleukin-11 receptor subunit alpha precursor",
        "tax_id": 9606,
        "disease": "craniosynostosis and dental anomalies (MONDO:MONDO:0013615)",
        "pathway": " (hsa:3590);  (R-HSA-6788467)",
        "pathway_count": 2,
        "publication_count": 50,
        "publication_id_list": "10.1101/2023.09.13.557529;10586060;10812968;10966616;11141475;11237011;11834704;11943154;12601009;12707266;12811586;15450249;15519241;16051226;19920145;21715184;21741611;24715725;26876177;2779549;29242379;29557506;30279168;31844290;31848261;31998317;32157095;32350084;32387766;32502341;33968037;34509645;35051231;35251023;35331937;36376885;37820452;39341516;7670098;7738033;7852997;7862649;7957045;8119965;8272873;8390097;8627290;8637716;8808281;9238703",
        "class_list": "",
        "function": "Biophysical insight into protein-protein interactions in the Interleukin-11/Interleukin-11Ralpha/glycoprotein 130 signaling complex., [RefSeq, PubMed]; IL-11 system participates in pulmonary artery remodeling and hypertension in pulmonary fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Interleukin 11 is a stromal cell-derived cytokine that belongs to a family of pleiotropic and redundant cytokines that use the gp130 transducing subunit in their high affinity receptors. This gene encodes the IL-11 receptor, which is a member of the hematopoietic cytokine receptor family. This particular receptor is very similar to ciliary neurotrophic factor, since both contain an extracellular region with a 2-domain structure composed of an immunoglobulin-like domain and a cytokine receptor-like domain. Multiple alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jun 2012]., [RefSeq]; Interleukin-11Ralpha2 in the hypothalamic arcuate nucleus affects depression-related behaviors and the AKT-BDNF pathway., [RefSeq, PubMed]; Receptor for interleukin-11 (IL11). The receptor systems for IL6, LIF, OSM, CNTF, IL11 and CT1 can utilize IL6ST for initiating signal transmission. The IL11/IL11RA/IL6ST complex may be involved in the control of proliferation and/or differentiation of skeletogenic progenitor or other mesenchymal cells (Probable). Essential for the normal development of craniofacial bones and teeth. Restricts suture fusion and tooth number., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity (PubMed:26876177, PubMed:30279168). The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling (PubMed:26876177, PubMed:30279168)., [UniProtKB, PubMed, PubMed]; Soluble form of IL11 receptor (sIL11RA) that acts as an agonist of IL11 activity. The IL11:sIL11RA complex binds to IL6ST/gp130 on cell surfaces and induces signaling also on cells that do not express membrane-bound IL11RA in a process called IL11 trans-signaling., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The outcome of targeted NGS screening in patients with syndromic forms of sagittal and pansynostosis - IL11RA is an emerging core-gene for pansynostosis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16542;Q5VZ80;Q7KYJ7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004921 interleukin-11 receptor activity;GO:0019970 interleukin-11 binding;GO:0004888 transmembrane signaling receptor activity;GO:0004896 cytokine receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0032502 developmental process;GO:0007566 embryo implantation;GO:0019221 cytokine-mediated signaling pathway;GO:0060322 head development",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q14626-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NFD8-3",
        "uniprot_id": [
            {
                "id": "HELT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NFD8",
                "type": "external"
            }
        ],
        "mass": 26913.0,
        "length": 242,
        "protein_name": "Hairy and enhancer of split-related protein HELT",
        "gene_name": "HELT",
        "organism": "Human",
        "refseq_name": "hairy and enhancer of split-related protein HELT isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001287710",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287710",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HELT",
        "gene_names_refseq": "HCM1228; HELT; HESL; Mgn; bHLHb44",
        "protein_names_uniprotkb": "Hairy and enhancer of split-related protein HELT; HES/HEY-like transcription factor",
        "protein_names_refseq": "HES/HEY-like transcription factor; Hairy and enhancer of split-related protein HELT; Hes-like transcription factor; Hey-like transcription factor; Hey-like transcriptional repressor; Megane bHLH factor; hairy and enhancer of split-related protein HELT isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:391723)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "15375612;26582913;31844290",
        "class_list": "",
        "function": "Activation of DPF3a upon hypertrophic stimuli in cardiac hypertrophy switches cardiac fetal gene expression from being silenced by HEY to being activated by BRG1., [RefSeq, PubMed]; Identified and characterized human HES-like (HESL), rat hesl, and rainbow trout hesl genes by using bioinformatics, [RefSeq, PubMed]; Transcriptional repressor which binds preferentially to the canonical E box sequence 5'-CACGCG-3'., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RTS5;B7ZMI7;B7ZMI8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007219 Notch signaling pathway;GO:0009952 anterior/posterior pattern specification;GO:0050767 regulation of neurogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "A6NFD8-3",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99547-1",
        "uniprot_id": [
            {
                "id": "MPH6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99547",
                "type": "external"
            }
        ],
        "mass": 19024.0,
        "length": 160,
        "protein_name": "M-phase phosphoprotein 6",
        "gene_name": "MPHOSPH6",
        "organism": "Human",
        "refseq_name": "M-phase phosphoprotein 6",
        "refseq_ac": [
            {
                "id": "NP_005783",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005783",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MPHOSPH6; MPP6",
        "gene_names_refseq": "MPHOSPH6; MPP-6; MPP6; MPP",
        "protein_names_uniprotkb": "M-phase phosphoprotein 6",
        "protein_names_refseq": "M-phase phosphoprotein 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10200);  (R-HSA-6791226);  (R-HSA-9930044)",
        "pathway_count": 3,
        "publication_count": 83,
        "publication_id_list": "11237011;11719186;11922599;12068309;12150911;15231747;16037817;16043514;16396833;16738141;17081983;17174896;17189298;17322306;17353269;17412707;18065403;18212344;18438418;18452278;18669648;18691976;19106111;19332556;19564402;19664995;19690332;19801658;20038530;20056613;20068231;20531386;20531389;20798176;20805244;20819938;21036871;21063389;21097556;21705430;21855801;22072790;22190735;22195017;22916032;23186163;23439679;23481700;23482395;2388630;24424021;24550520;25525153;25576301;25578728;25772364;25969445;26166824;26237581;27434818;27846572;27871484;27920218;28510447;28832583;29242379;29298432;29557506;29906447;31844290;31950173;32157095;32938616;32983136;33592498;33691108;33767452;33913806;33968037;35580925;37875486;8885239;9482744",
        "class_list": "",
        "function": "MPP6 is a nucleolus-specific exosome co-factor required for its role in the maturation of 5.8S rRNA. Publication Status: Online-Only, [RefSeq, PubMed]; MPP6 was found to be associated with the exosome, a multiprotein complex involved in RNA degradation., [RefSeq, PubMed]; RNA-binding protein that associates with the RNA exosome complex. Involved in the 3'-processing of the 7S pre-RNA to the mature 5.8S rRNA and play a role in recruiting the RNA exosome complex to pre-rRNA; this function may include C1D., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RAF0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000178 exosome (RNase complex)",
        "go_biological_process": "GO:0000460 maturation of 5.8S rRNA",
        "synthesized_glycan_count": 0,
        "hit_score": 8.6,
        "record_id": "Q99547-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P13598-1",
        "uniprot_id": [
            {
                "id": "ICAM2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P13598",
                "type": "external"
            }
        ],
        "mass": 30654.0,
        "length": 275,
        "protein_name": "Intercellular adhesion molecule 2",
        "gene_name": "ICAM2",
        "organism": "Human",
        "refseq_name": "intercellular adhesion molecule 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_000864",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000864",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ICAM2",
        "gene_names_refseq": "CD102; ICAM2",
        "protein_names_uniprotkb": "Intercellular adhesion molecule 2; ICAM-2",
        "protein_names_refseq": "ICAM-2; intercellular adhesion molecule 2 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3384);  (R-HSA-198933);  (R-HSA-216083);  (R-HSA-5621575)",
        "pathway_count": 4,
        "publication_count": 217,
        "publication_id_list": "10077629;10209034;10366422;10438935;10499918;10543983;10593924;10605720;10640428;10673366;10713152;10721994;10746781;10811134;10982388;11017109;11158588;11237011;11265639;11489943;11513152;11518510;11556966;11572855;11713259;11807247;11857637;11858820;11861603;11955593;11955595;11955599;11980922;12213321;12456660;12483297;12496264;12515809;12585966;12588680;12628924;12682293;12807887;14719373;14970179;15034010;15136729;15155468;15187158;15240572;15304001;15330449;15345499;15383545;15520807;15534202;15541655;15580655;15607800;15713743;15778510;15781451;15800062;15851719;15864273;1588291;15899827;16002701;16014749;16051604;16091383;16129954;16135789;16239428;16335952;16339513;16380601;16434485;16551255;16731529;16737824;16754661;16754721;1676048;16893496;16904340;16928187;16933105;17045824;17057721;17237375;17337780;17339034;17462920;17968485;18031695;18037897;18055229;18209062;18234675;18385332;18593354;18710925;18775695;19122653;19149696;19197368;19349973;19359216;19502598;19592130;19892738;20033473;2010551;20363321;20705068;20730098;21241660;21800138;21841309;21877119;22396535;22539938;22645359;22884367;23090970;23345538;23374253;23695528;23929856;24190977;24305946;2497351;25418920;25502872;25703557;25716998;26024233;26154972;26284469;26300885;26992070;27556181;27592383;28063628;28218747;28228285;28467828;29242379;29314611;29317506;29391424;29393594;29437277;29493099;29557506;29632046;29632711;29671117;29671580;29786170;30315122;30410026;31092671;31154438;31611695;31844290;31848261;32157095;32350084;32897882;32983136;33123756;33298915;33633747;33717175;33912179;33936100;33968037;34019948;34357683;34433824;34484188;34561969;35051231;35154160;35251023;35580925;37074911;37759298;7505120;7517401;7525578;7531291;7541634;7542249;7542404;7559467;7685013;8118028;8178173;8344274;8560266;8798654;8838667;8910476;8995416;9153399;9251239;9285412;9314561;9443892;9565552;9660950;9700512;9730896;9858236",
        "class_list": "glycogene",
        "function": "Cell adhesion molecule that functions as a receptor ligand of the signaling receptor ITGAL:ITGB2/LFA-1 (lymphocyte-function associated (LFA) molecule 1) ensuring leukocyte cell-cell adhesion on resting cells (PubMed:10077629, PubMed:1676048, PubMed:2497351). Also endothelial blood vessels receptor ligand of dendritic cell (DC) CD209 signaling receptor that mediates triggering transendothelial migration of DC presursors from blood into peripheral tissues and, subsequently, into lymphoid tissues (PubMed:11017109). Mediates adhesive interactions important for antigen presentation, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; ICAM-1 and ICAM-2 Are Differentially Expressed and Up-Regulated on Inflamed Pulmonary Epithelium, but Neither ICAM-2 nor LFA-1: ICAM-1 Are Required for Neutrophil Migration Into the Airways In Vivo. Publication Status: Online-Only, [RefSeq, PubMed]; ICAM2 induction by p53 has a key role in inhibiting cancer cell migration and invasion.ICAM2 acts at least in part through the suppression of the MEK-ERK signaling pathway., [RefSeq, PubMed]; INDEED also identified some candidates previously reported to be relevant to HCC, such as intercellular adhesion molecule 2 (ICAM2) and c4b-binding protein alpha chain (C4BPA), which were missed by both Differential expression and differential network analyses, [RefSeq, PubMed]; Intercellular adhesion molecule 2 as a novel prospective tumor suppressor induced by ERG promotes ubiquitination-mediated radixin degradation to inhibit gastric cancer tumorigenicity and metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; Lewis-antigen-containing ICAM-2/3 on Jurkat leukemia cells interact with DC-SIGN to regulate DC functions., [RefSeq, PubMed]; The protein encoded by this gene is a member of the intercellular adhesion molecule (ICAM) family. All ICAM proteins are type I transmembrane glycoproteins, contain 2-9 immunoglobulin-like C2-type domains, and bind to the leukocyte adhesion LFA-1 protein. This protein may play a role in lymphocyte recirculation by blocking LFA-1-dependent cell adhesion. It mediates adhesive interactions important for antigen-specific immune response, NK-cell mediated clearance, lymphocyte recirculation, and other cellular interactions important for immune response and surveillance. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 8,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 354,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 26,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14600",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032154 cleavage furrow;GO:0005902 microvillus;GO:0001931 uropod",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0033627 cell adhesion mediated by integrin;GO:0007159 leukocyte cell-cell adhesion;GO:0036336 dendritic cell migration;GO:0098609 cell-cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 25.3,
        "record_id": "P13598-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000000.100.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9C073-1",
        "uniprot_id": [
            {
                "id": "F117A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9C073",
                "type": "external"
            }
        ],
        "mass": 48319.0,
        "length": 453,
        "protein_name": "Protein FAM117A",
        "gene_name": "FAM117A",
        "organism": "Human",
        "refseq_name": "protein FAM117A isoform 1",
        "refseq_ac": [
            {
                "id": "NP_110429",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110429",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM117A",
        "gene_names_refseq": "FAM117A",
        "protein_names_uniprotkb": "Protein FAM117A; C/EBP-induced protein",
        "protein_names_refseq": "C/EBP-induced protein; protein FAM117A isoform 1; protein FAM117A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81558)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "11237011;19651622;19664994;19690332;21406692;23186163;23481700;24275569;24714562;24715725;25576301;26992070;27846572;27862975;27920218;28832583;28904123;29242379;29437277;29632711;30315122;30379171;31217245;31844290;32157095;33141586;33298915;33912179;33936100;34171305;34211107;35580925;36284347",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
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        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z7Q3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q9C073-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BQD7-1",
        "uniprot_id": [
            {
                "id": "ANKMT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BQD7",
                "type": "external"
            }
        ],
        "mass": 25130.0,
        "length": 235,
        "protein_name": "Adenine nucleotide translocase lysine N-methyltransferase",
        "gene_name": "ANTKMT",
        "organism": "Human",
        "refseq_name": "adenine nucleotide translocase lysine N-methyltransferase isoform 1",
        "refseq_ac": [
            {
                "id": "NP_076422",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076422",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ANTKMT; C16orf24; FAM173A; RJD7",
        "gene_names_refseq": "ANT-KMT; ANTKMT; C16orf24; FAM173A",
        "protein_names_uniprotkb": "Adenine nucleotide translocase lysine N-methyltransferase; 2.1.1.-; ANT-KMT",
        "protein_names_refseq": "adenine nucleotide translocase lysine N-methyltransferase isoform 1; adenine nucleotide translocase lysine N-methyltransferase; family with sequence similarity 173 member A; protein FAM173A; protein N-lysine methyltransferase FAM173A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:65990)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;23481700;24715725;26811146;26992070;27920218;28218747;28514659;29242379;29331515;29437277;29557506;29632046;30315122;31213526;31844290;32161166;32502341;33141586;35051231",
        "class_list": "",
        "function": "FAM173A is the long-sought mitochondrial lysine-specific methyltransferase responsible for adenine nucleotide translocase methylation at Lys-52, and point out the functional significance of Lys-52 methylation in adenine nucleotide translocase., [RefSeq, PubMed]; Mitochondrial protein-lysine N-methyltransferase that trimethylates adenine nucleotide translocases ANT2/SLC25A5 and ANT3/SLC25A6, thereby regulating mitochondrial respiration (PubMed:31213526). Probably also trimethylates ANT1/SLC25A4 (PubMed:31213526)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_s_glycosites": 0,
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        "reported_mutagensis": 3,
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        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A2IDD4",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "2.1.1.359",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359",
                "type": "external"
            },
            {
                "id": "2.1.1.372",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016279 protein-lysine N-methyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane",
        "go_biological_process": "GO:0018023 peptidyl-lysine trimethylation;GO:1905706 regulation of mitochondrial ATP synthesis coupled proton transport;GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q9BQD7-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15884-3",
        "uniprot_id": [
            {
                "id": "EREP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15884",
                "type": "external"
            }
        ],
        "mass": 49703.0,
        "length": 450,
        "protein_name": "Endosomal transmembrane epsin interactor 1",
        "gene_name": "ENTREP1",
        "organism": "Human",
        "refseq_name": "endosomal transmembrane epsin interactor 1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001334924",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001334924",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ENTREP1; C9orf61; FAM189A2; X123",
        "gene_names_refseq": "C9orf61; ENTREP1; ENTREP; FAM189A2; X123",
        "protein_names_uniprotkb": "Endosomal transmembrane epsin interactor 1; Endosomal transmembrane binding with epsin",
        "protein_names_refseq": "Friedreich ataxia region gene X123; Protein FAM189A2; endosomal transmembrane binding with epsin; endosomal transmembrane epsin interactor 1 isoform a; family with sequence similarity 189 member A2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9413)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "21406692;32938616;34927784;36010968;38878656;7951235",
        "class_list": "",
        "function": "ENTREP/FAM189A2 encodes a new ITCH ubiquitin ligase activator that is downregulated in breast cancer., [RefSeq, PubMed]; FAM189A2 plays a tumour suppressor role in lung adenocarcinoma by influencing cell apoptosis, CXCR4 expression and tight junction proteins., [RefSeq, PubMed]; Functions as an activator of the E3 ubiquitin protein ligase ITCH in the ubiquitination of the CXCL12-activated CXCR4 receptor. Thereby, triggers CXCR4 endocytosis and desensitization, negatively regulating the CXCL12/CXCR4 signaling pathway., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0A0MR12;A0A6F8PH59;Q14CN5;Q5T6C8;Q5T6C9;Q6ZTX4;Q96N10",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990757 ubiquitin ligase activator activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0031902 late endosome membrane;GO:0031901 early endosome membrane;GO:0055038 recycling endosome membrane",
        "go_biological_process": "GO:0031623 receptor internalization;GO:0038160 CXCL12-activated CXCR4 signaling pathway;GO:0022401 negative adaptation of signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q15884-3",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96F46-1",
        "uniprot_id": [
            {
                "id": "I17RA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96F46",
                "type": "external"
            }
        ],
        "mass": 96122.0,
        "length": 866,
        "protein_name": "Interleukin-17 receptor A",
        "gene_name": "IL17RA",
        "organism": "Human",
        "refseq_name": "interleukin-17 receptor A isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001276834",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001276834",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL17RA; IL17R",
        "gene_names_refseq": "CANDF5; CD217; CDw217; IL-17RA; IL17RA; IL17R; IMD51; hIL-17R",
        "protein_names_uniprotkb": "Interleukin-17 receptor A; CDw217; IL-17 receptor A; IL-17RA",
        "protein_names_refseq": "IL-17 receptor A; interleukin-17 receptor A isoform 2 precursor",
        "tax_id": 9606,
        "disease": "immunodeficiency 51 (Disease Ontology:DOID:0111996)",
        "pathway": " (hsa:23765);  (R-HSA-448424);  (R-HSA-9705671)",
        "pathway_count": 3,
        "publication_count": 130,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11574464;11966773;12019269;12692549;12759408;15208624;15340161;16397230;16785495;17911633;18477386;18684971;19838198;21350122;21993848;21993849;22941947;23090970;23186163;23481700;23695682;23834281;24084331;24120361;24190977;25502872;25576301;26154972;26375851;26871944;26992070;27600516;27726376;27862975;28827714;28832583;28904123;29242379;29493099;29508533;29557506;29786170;30418433;30429286;31020640;31154438;31844290;31848261;31850239;32157095;32187518;32350084;32353859;32428392;32589897;32726803;32728199;32897882;32938616;32953130;32979938;32983136;33024073;33043033;33060197;33097660;33110251;33123756;33349665;33360543;33372174;33372854;33392160;33396605;33440148;33479219;33495715;33514628;33567255;33592498;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33963333;33989516;33990585;34021074;34054808;34084167;34087483;34110168;34166398;34239064;34290717;34341353;34357683;34375313;34400613;34439781;34452305;34471099;34502139;34597346;34932366;35051231;35102342;35154160;35289036;35580925;35643212;36215666;36284347;36979355;37051252;37074911;37239484;37686343;37926850;37938771;38491831;38665916;8777726;9367539",
        "class_list": "",
        "function": "(Microbial infection) Receptor for SARS coronavirus-2/SARS-CoV-2 virus protein ORF8, leading to IL17 pathway activation and an increased secretion of pro-inflammatory factors through activating NF-kappa-B signaling pathway., [UniProtKB, PubMed]; Association between IL-17F, IL-17RA Gene Polymorphisms and Response to Biological Drugs in Psoriasis and Beyond. Publication Status: Online-Only, [RefSeq, PubMed]; Decreased interleukin-17RA expression is associated with good prognosis in patients with colorectal cancer and inhibits tumor growth and vascularity in mice., [RefSeq, PubMed]; Expression, modulation and signalling of IL-17 receptor in fibroblast-like synoviocytes of patients with rheumatoid arthritis, [RefSeq, PubMed]; Genetic association between interleukin-17 and susceptibility to rheumatoid arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; Immunogenic Cell Death Associated Molecular Patterns and the Dual Role of IL17RA in Interstitial Cystitis/Bladder Pain Syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Interleukin 17A (IL17A) is a proinflammatory cytokine secreted by activated T-lymphocytes. It is a potent inducer of the maturation of CD34-positive hematopoietic precursors into neutrophils. The transmembrane protein encoded by this gene (interleukin 17A receptor; IL17RA) is a ubiquitous type I membrane glycoprotein that binds with low affinity to interleukin 17A. Interleukin 17A and its receptor play a pathogenic role in many inflammatory and autoimmune diseases such as rheumatoid arthritis. Like other cytokine receptors, this receptor likely has a multimeric structure. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Feb 2014]., [RefSeq]; Mechanistic Insights into the Roles of the IL-17/IL-17R Families in Pancreatic Cancer. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for IL17A and IL17F, major effector cytokines of innate and adaptive immune system involved in antimicrobial host defense and maintenance of tissue integrity. Receptor for IL17A (PubMed:17911633, PubMed:9367539). Receptor for IL17F (PubMed:17911633, PubMed:19838198). Binds to IL17A with higher affinity than to IL17F (PubMed:17911633). Binds IL17A and IL17F homodimers as part of a heterodimeric complex with IL17RC (PubMed:16785495). Also binds heterodimers formed by IL17A and IL17F as part of a heterodimeric complex with IL17RC (PubMed:18684971). Cytokine binding triggers homotypic interaction of IL17RA and IL17RC chains with TRAF3IP2 adapter, leading to TRAF6-mediated activation of NF-kappa-B and MAPkinase pathways, ultimately resulting in transcriptional activation of cytokines, chemokines, antimicrobial peptides and matrix metalloproteinases, with potential strong immune inflammation (PubMed:16785495, PubMed:17911633, PubMed:18684971, PubMed:21350122, PubMed:24120361). Involved in antimicrobial host defense primarily promoting neutrophil activation and recruitment at infection sites to destroy extracellular bacteria and fungi (By similarity). In secondary lymphoid organs, contributes to germinal center formation by regulating the chemotactic response of B cells to CXCL12 and CXCL13, enhancing retention of B cells within the germinal centers, B cell somatic hypermutation rate and selection toward plasma cells (By similarity). Plays a role in the maintenance of the integrity of epithelial barriers during homeostasis and pathogen infection. Stimulates the production of antimicrobial beta-defensins DEFB1, DEFB103A, and DEFB104A by mucosal epithelial cells, limiting the entry of microbes through the epithelial barriers (By similarity). Involved in antiviral host defense through various mechanisms. Enhances immunity against West Nile virus by promoting T cell cytotoxicity. Contributes to Influenza virus clearance by driving the differentiation of B-1a B cells, providing for production of virus-specific IgM antibodies at first line of host defense (By similarity). Receptor for IL17C as part of a heterodimeric complex with IL17RE (PubMed:21993848)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 7,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
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        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 11,
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        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43844;Q20WK1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030368 interleukin-17 receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0032747 positive regulation of interleukin-23 production;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 15.0,
        "record_id": "Q96F46-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q04912-1",
        "uniprot_id": [
            {
                "id": "RON_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q04912",
                "type": "external"
            }
        ],
        "mass": 152241.0,
        "length": 1400,
        "protein_name": "Macrophage-stimulating protein receptor",
        "gene_name": "MST1R",
        "organism": "Human",
        "refseq_name": "macrophage-stimulating protein receptor isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001231866",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001231866",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MST1R; PTK8; RON",
        "gene_names_refseq": "CD136; CDw136; MST1R; NPCA3; PTK8; RON; SEA; p185-Ron",
        "protein_names_uniprotkb": "Macrophage-stimulating protein receptor; 2.7.10.1; CDw136; MSP receptor; Protein-tyrosine kinase 8; p185-Ron",
        "protein_names_refseq": "MSP receptor; PTK8 protein tyrosine kinase 8; S13 avian erythroblastosis oncogene homolog; S13 erythroblastosis oncogene homolog; c-met-related tyrosine kinase; macrophage-stimulating protein receptor isoform 2 precursor",
        "tax_id": 9606,
        "disease": "nasopharynx carcinoma (Disease Ontology:DOID:9261); nasopharyngeal carcinoma, susceptibility to, 3 (MONDO:MONDO:0014902)",
        "pathway": " (hsa:4486);  (R-HSA-8852405)",
        "pathway_count": 2,
        "publication_count": 60,
        "publication_id_list": "10.1101/2023.09.13.557529;10222149;10514476;10871856;11237011;12472665;12676986;12802274;14505491;15184888;15632155;15792801;17344846;18593464;18836480;1885621;20228799;20545605;20726546;21784853;21875933;22087277;22848655;24409221;24739671;25193665;26951679;29242379;30779550;32157095;32938616;33508385;33537174;33673346;33968037;33981976;34087483;34171305;34185709;34347914;34821550;35051231;35318648;35580925;36215666;36241641;36284347;36833444;37074911;37186866;7687741;7939629;8062829;8346233;8386824;8816464;9045873;9202013;9657372;9764835",
        "class_list": "",
        "function": "A potential signaling axis between RON kinase receptor and hypoxia-inducible factor-1 alpha in pancreatic cancer., [RefSeq, PubMed]; An Introduction and Overview of RON Receptor Tyrosine Kinase Signaling. Review article Publication Status: Online-Only, [RefSeq, PubMed]; EGFR transactivates RON to drive oncogenic crosstalk. Publication Status: Online-Only, [RefSeq, PubMed]; Evidence for 2-Methoxyestradiol-Mediated Inhibition of Receptor Tyrosine Kinase RON in the Management of Prostate Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to MST1 ligand. Regulates many physiological processes including cell survival, migration and differentiation. Ligand binding at the cell surface induces autophosphorylation of RON on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with the PI3-kinase subunit PIK3R1, PLCG1 or the adapter GAB1. Recruitment of these downstream effectors by RON leads to the activation of several signaling cascades including the RAS-ERK, PI3 kinase-AKT, or PLCgamma-PKC. RON signaling activates the wound healing response by promoting epithelial cell migration, proliferation as well as survival at the wound site. Also plays a role in the innate immune response by regulating the migration and phagocytic activity of macrophages. Alternatively, RON can also promote signals such as cell migration and proliferation in response to growth factors other than MST1 ligand., [UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a cell surface receptor for macrophage-stimulating protein (MSP) with tyrosine kinase activity. The mature form of this protein is a heterodimer of disulfide-linked alpha and beta subunits, generated by proteolytic cleavage of a single-chain precursor. The beta subunit undergoes tyrosine phosphorylation upon stimulation by MSP. This protein is expressed on the ciliated epithelia of the mucociliary transport apparatus of the lung, and together with MSP, thought to be involved in host defense. Alternative splicing generates multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing. [provided by RefSeq, Jan 2016]., [RefSeq]; Tumor cell intrinsic RON signaling suppresses innate immune responses in breast cancer through inhibition of IRAK4 signaling., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 6,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 71,
        "reported_interactions": 0,
        "missing_score": 9848,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 2,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A087WZG2;B5A944;B5A945;B5A946;B5A947",
        "ec_number_list": [
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005011 macrophage colony-stimulating factor receptor activity;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0017154 semaphorin receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0001725 stress fiber;GO:0005773 vacuole",
        "go_biological_process": "GO:0006952 defense response;GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007399 nervous system development;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q04912-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1000000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P22626-1",
        "uniprot_id": [
            {
                "id": "ROA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P22626",
                "type": "external"
            }
        ],
        "mass": 37430.0,
        "length": 353,
        "protein_name": "Heterogeneous nuclear ribonucleoproteins A2/B1",
        "gene_name": "HNRNPA2B1",
        "organism": "Human",
        "refseq_name": "heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2",
        "refseq_ac": [
            {
                "id": "NP_002128",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002128",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HNRNPA2B1; HNRPA2B1",
        "gene_names_refseq": "HNRNPA2B1; HNRNPA2; HNRNPB1; HNRPA2B1; HNRPA2; HNRPB1; IBMPFD2; OPDM2; OPMD2; RNPA2; SNRPB1",
        "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1",
        "protein_names_refseq": "HNRNPA2B1/MYC fusion; epididymis secretory sperm binding protein; heterogeneous nuclear ribonucleoproteins A2/B1 isoform A2; heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2 / hnRNP B1; nuclear ribonucleoprotein particle A2 protein",
        "tax_id": 9606,
        "disease": "inclusion body myopathy with Paget disease of bone and frontotemporal dementia (Disease Ontology:DOID:0050881); inclusion body myopathy with early-onset Paget disease of bone with or without frontotemporal dementia 2 (Disease Ontology:DOID:0111384); Alzheimer's disease (Disease Ontology:DOID:10652); neurodegenerative disease (Disease Ontology:DOID:1289); transient cerebral ischemia (Disease Ontology:DOID:224); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic carcinoma (Disease Ontology:DOID:4905); hepatocellular carcinoma (Disease Ontology:DOID:684); rheumatoid arthritis (Disease Ontology:DOID:7148); oculopharyngeal muscular dystrophy 2 (MONDO:MONDO:0958195)",
        "pathway": " (hsa:3181);  (R-HSA-72163);  (R-HSA-72203);  (R-HSA-8950505);  (R-HSA-9770562);  (R-HSA-9918481)",
        "pathway_count": 6,
        "publication_count": 309,
        "publication_id_list": "10380706;10567417;10669729;10772824;10882114;11014198;11060040;11101529;11233976;11237011;11747608;11991638;12176931;12411573;12414731;12477934;14519844;14625303;14654843;14713954;14749727;14762106;15004565;15037765;15084397;1522214;15294897;15302935;15565158;15703215;15782174;15944288;16038020;16314458;16809785;16964243;1699755;17004321;17074750;17095540;17128255;17287340;17289661;17332742;17377532;17606899;17924679;18212344;18220336;18288197;18322460;18452278;18491316;18566446;18593880;18669648;18691976;18991276;19099192;19103666;19117535;19165350;19217410;19369195;19413330;19415658;19429692;19536130;19608861;19615748;19651622;19664995;19690332;20010808;20058876;20068231;20166139;20232340;20305658;20423332;20695905;20980672;21295486;21406692;21536652;2176635;21911577;22110043;22121020;22322011;22365833;22424782;22813749;22905912;22959432;22961380;23137016;23186163;23222130;23236153;23345524;23455423;23481700;23555621;23576270;23719902;23874216;23919377;24076191;24098712;24126823;24129315;24149845;24196718;24275569;24304693;24316715;24356509;24407421;24448447;24549040;24714562;24715725;24737827;24914973;24981863;25218447;25301780;25301781;25418920;25469497;25555158;2557628;25576301;2558966;25645385;25678563;25755297;25802875;25810538;25880248;25892735;26092250;26154972;26321680;26375851;26385511;26420826;26544936;26758079;26811146;26969736;26992070;27108190;27377154;27397612;27459055;27683217;27846572;27862975;28062851;28076346;28096519;28502770;28649982;28781166;28832583;28904123;28911096;29186539;29242379;29274231;29301961;29317506;29351928;29360106;29361316;29371260;29393594;29437277;29493099;29557506;2963332;29769354;29789417;29902443;30059200;30139799;30257008;30315122;30315277;30379171;30410026;30429286;30444036;30484775;30599162;30620550;30705154;30728453;30765414;30833945;30975767;31020640;31154438;31217245;31222486;31235510;31320558;31373491;31409651;31492838;31530632;31611695;31844290;31848261;31998317;32119511;32157095;32161166;32179686;32265295;32329775;32350084;32357974;32387766;32488085;32494006;32502341;32816001;32897882;32938616;32983136;33043033;33123756;33141586;33177556;33214551;33243851;33298915;33392160;33446560;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34301950;34509645;34561969;34725712;34822310;34932366;35051231;35083852;35154160;35177536;35215846;35251023;35318648;35385551;35484142;35513511;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37217939;3733753;3757028;37938771;38626369;38665916;38862832;39166862;39177591;39268079;39349455;39990658;40307207;40596516;40914422;7789969;7980541;8029005;8352591;8566756;8608946;9016565;9242493;9409616;9512519;9524131;9539711;9659921;9671485;9701291;9731529",
        "class_list": "",
        "function": "(Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport., [UniProtKB, PubMed, PubMed]; HNRNPA2B1 induces cell proliferation and acts as biomarker in breast cancer., [RefSeq, PubMed]; HNRNPA2B1 stabilizes NFATC3 levels to potentiate its combined actions with FOSL1 to mediate vasculogenic mimicry in GBM cells. Publication Status: Online-Only, [RefSeq, PubMed]; Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays a role in the splicing of pyruvate kinase PKM by binding repressively to sequences flanking PKM exon 9, inhibiting exon 9 inclusion and resulting in exon 10 inclusion and production of the PKM M2 isoform (PubMed:20010808). Also plays a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; HnRNPA2B1 ISGylation Regulates m6A-Tagged mRNA Selective Export via ALYREF/NXF1 Complex to Foster Breast Cancer Development., [RefSeq, PubMed]; The Potential Impact of HNRNPA2B1 on Human Cancers Prognosis and Immune Microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]; The hnRNP A2B1 is important for the replication of SFTSV and other RNA viruses., [RefSeq, PubMed]; This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 26,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 10,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A024RA27;A0A024RA61;A8K064;P22627;Q9UC98;Q9UDJ2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0098505 G-rich strand telomeric DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0070182 DNA polymerase binding;GO:0035198 miRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0006406 mRNA export from nucleus;GO:0000398 mRNA splicing, via spliceosome;GO:0050658 RNA transport;GO:1904358 positive regulation of telomere maintenance via telomere lengthening",
        "synthesized_glycan_count": 0,
        "hit_score": 31.6,
        "record_id": "P22626-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14979-1",
        "uniprot_id": [
            {
                "id": "HNRDL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14979",
                "type": "external"
            }
        ],
        "mass": 46438.0,
        "length": 420,
        "protein_name": "Heterogeneous nuclear ribonucleoprotein D-like",
        "gene_name": "HNRNPDL",
        "organism": "Human",
        "refseq_name": "heterogeneous nuclear ribonucleoprotein D-like isoform b",
        "refseq_ac": [
            {
                "id": "NP_001193929",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193929",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HNRNPDL; HNRPDL; JKTBP",
        "gene_names_refseq": "HNRNPDL; HNRNP; HNRPDL; JKTBP2; JKTBP; LGMD1G; LGMDD3; laAUF1",
        "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein D-like; AU-rich element RNA-binding factor; JKT41-binding protein; Protein laAUF1; hnRNP D-like; hnRNP DL",
        "protein_names_refseq": "A+U-rich element RNA binding factor; AU-rich element RNA-binding factor; JKT41-binding protein; heterogeneous nuclear ribonucleoprotein D-like isoform b; hnRNP D-like; hnRNP DL; limb girdle muscular dystrophy 1G (autosomal dominant); protein laAUF1",
        "tax_id": 9606,
        "disease": "autosomal dominant limb-girdle muscular dystrophy type 3 (Disease Ontology:DOID:0110306)",
        "pathway": " (hsa:9987);  (R-HSA-8950505)",
        "pathway_count": 2,
        "publication_count": 112,
        "publication_id_list": "10072754;11237011;11705999;12406575;15190078;15302935;16038020;17081983;17377532;18452278;19413330;19608861;19651622;19664994;19664995;19690332;20058876;20068231;20305658;21406692;21740066;22121020;22967762;23186163;24129315;24275569;24366607;24647604;24714562;24715725;25576301;25645385;25880248;25892735;26154972;26375851;26728094;26992070;27397612;28063628;28510447;28514659;28832583;28834231;28904123;29242379;29331515;29493099;29508533;29557506;29632046;29632711;29789417;30315122;30429286;30444036;30484775;30779550;30833945;31154438;31217245;31222486;31488872;31530632;31844290;31848261;32119511;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33214551;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34211107;34229054;34725712;34932366;35008409;35051231;35083852;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36646699;37938771;38665916;39302247;40914422;9524220;9538234",
        "class_list": "",
        "function": "Acts as a transcriptional regulator. Promotes transcription repression. Promotes transcription activation in differentiated myotubes (By similarity). Binds to double- and single-stranded DNA sequences. Binds to the transcription suppressor CATR sequence of the COX5B promoter (By similarity). Binds with high affinity to RNA molecules that contain AU-rich elements (AREs) found within the 3'-UTR of many proto-oncogenes and cytokine mRNAs. Binds both to nuclear and cytoplasmic poly(A) mRNAs. Binds to poly(G) and poly(A), but not to poly(U) or poly(C) RNA homopolymers. Binds to the 5'-ACUAGC-3' RNA consensus sequence., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Cryo-EM structure of hnRNPDL-2 fibrils, a functional amyloid associated with limb-girdle muscular dystrophy D3. Publication Status: Online-Only, [RefSeq, PubMed]; HNRPDL transforms hematopoietic cells and a novel HNRPDL/PBX1 axis plays an important role in human CML CD34(+) cells, [RefSeq, PubMed]; This gene belongs to the subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two RRM domains that bind to RNAs. Three alternatively spliced transcript variants have been described for this gene. One of the variants is probably not translated because the transcript is a candidate for nonsense-mediated mRNA decay. The protein isoforms encoded by this gene are similar to its family member HNRPD. [provided by RefSeq, May 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6SPF2;Q7KZ74;Q7KZ75;Q96IM0;Q96S43",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding;GO:0003697 single-stranded DNA binding;GO:0008143 poly(A) binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0005681 spliceosomal complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006396 RNA processing;GO:0010468 regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "O14979-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P86397-1",
        "uniprot_id": [
            {
                "id": "HTD2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P86397",
                "type": "external"
            }
        ],
        "mass": 18559.0,
        "length": 168,
        "protein_name": "Hydroxyacyl-thioester dehydratase type 2, mitochondrial",
        "gene_name": "HTD2",
        "organism": "Human",
        "refseq_name": "hydroxyacyl-thioester dehydratase type 2, mitochondrial",
        "refseq_ac": [
            {
                "id": "NP_001335641",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335641",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HTD2",
        "gene_names_refseq": "HTD2",
        "protein_names_uniprotkb": "Hydroxyacyl-thioester dehydratase type 2, mitochondrial; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase; 4.2.1.59; HsHTD2",
        "protein_names_refseq": "3-hydroxyacyl-[acyl-carrier-protein] dehydratase; hydroxyacyl-thioester dehydratase type 2, mitochondrial",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:109703458);  (R-HSA-75105)",
        "pathway_count": 2,
        "publication_count": 38,
        "publication_id_list": "10229681;11237011;12689621;13651131;1371749;15610069;15668256;15907797;16854592;17898086;17978863;18455495;19571038;20470824;22102020;22465940;23700546;23932781;24286864;25203508;27892461;28514659;28832583;28904123;30484775;31492838;31844290;33912179;36241641;3805044;5810867;627544;7567999;7732023;7901201;7909540;7916016;9341199",
        "class_list": "",
        "function": "Mitochondrial 3-hydroxyacyl-thioester dehydratase, which may be involved in fatty acid biosynthesis., [UniProtKB, PubMed]; This gene encodes a protein that localizes to the mitochondria and can function as a 3-hydroxyacyl thioester dehydratase. This gene is located just downstream of the gene for ribonuclease P/MRP subunit p14 (RPP14) in a genomic context that is conserved among animals. The upstream RPP14 gene is thought to be co-transcribed with this gene, and bicistronic transcripts may include open reading frames for both proteins. [provided by RefSeq, May 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "1.1.1.100",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100",
                "type": "external"
            },
            {
                "id": "1.3.1.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39",
                "type": "external"
            },
            {
                "id": "2.3.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38",
                "type": "external"
            },
            {
                "id": "2.3.1.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39",
                "type": "external"
            },
            {
                "id": "2.3.1.41",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41",
                "type": "external"
            },
            {
                "id": "2.3.1.85",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85",
                "type": "external"
            },
            {
                "id": "3.1.2.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14",
                "type": "external"
            },
            {
                "id": "4.2.1.59",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0019171 (3R)-hydroxyacyl-[acyl-carrier-protein] dehydratase activity;GO:0016836 hydro-lyase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006633 fatty acid biosynthetic process;GO:0046949 fatty-acyl-CoA biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "P86397-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86WZ0-1",
        "uniprot_id": [
            {
                "id": "HEAT4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86WZ0",
                "type": "external"
            }
        ],
        "mass": 117175.0,
        "length": 1026,
        "protein_name": "HEAT repeat-containing protein 4",
        "gene_name": "HEATR4",
        "organism": "Human",
        "refseq_name": "HEAT repeat-containing protein 4",
        "refseq_ac": [
            {
                "id": "NP_001207413",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001207413",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEATR4",
        "gene_names_refseq": "HEATR4",
        "protein_names_uniprotkb": "HEAT repeat-containing protein 4",
        "protein_names_refseq": "HEAT repeat-containing protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:399671)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;20736409;31848261;35051231;38253038",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z7V9;E9KL41",
        "ec_number_list": [],
        "go_molecular_function": "GO:0016491 oxidoreductase activity",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q86WZ0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7L5A8-1",
        "uniprot_id": [
            {
                "id": "FA2H_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7L5A8",
                "type": "external"
            }
        ],
        "mass": 42791.0,
        "length": 372,
        "protein_name": "Fatty acid 2-hydroxylase",
        "gene_name": "FA2H",
        "organism": "Human",
        "refseq_name": "fatty acid 2-hydroxylase",
        "refseq_ac": [
            {
                "id": "NP_077282",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077282",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FA2H; FAAH; FAXDC1",
        "gene_names_refseq": "FA2H; FAAH; FAH1; FAXDC1; SCS7; SPG35",
        "protein_names_uniprotkb": "Fatty acid 2-hydroxylase; 1.14.18.-; Fatty acid alpha-hydroxylase; Fatty acid hydroxylase domain-containing protein 1",
        "protein_names_refseq": "fatty acid 2-hydroxylase; fatty acid alpha-hydroxylase; fatty acid hydroxylase domain containing 1; fatty acid hydroxylase domain-containing protein 1; spastic paraplegia 35 (autosomal recessive)",
        "tax_id": 9606,
        "disease": "hereditary spastic paraplegia 35 (Disease Ontology:DOID:0110786)",
        "pathway": " (hsa:79152);  (R-HSA-1660661)",
        "pathway_count": 2,
        "publication_count": 80,
        "publication_id_list": "10722674;10751414;10802064;10947957;11237011;11937514;14685229;14685263;14976195;15063729;15328338;15337768;15863841;16100120;16118219;16571669;16793762;16895911;17023427;17050692;17331073;17355976;17449912;17591919;17982138;18165232;18165233;18184806;19005213;19068277;19233134;19416851;19506037;19531498;20061445;20104589;20110355;20182505;20853438;21620961;22517924;22970244;23180825;23602659;23754960;24569996;24782409;25576301;25788259;25892735;27862975;28575652;29242379;29331515;29393594;29557506;29563527;29769354;30779550;30833945;31092671;31154438;31848261;31895563;34171305;35051231;35409383;36284347;36902339;36907437;37224812;37390971;37410270;38253038;38306901;4339164;4817756;9188692;9312549;9363775",
        "class_list": "",
        "function": "A Novel Homozygous Deletion Including Exon 1 of FA2H Gene Causes Spastic Paraplegia-35: Genetic and Lipidomics Analysis of the Patients., [RefSeq, PubMed]; Catalyzes the hydroxylation of free fatty acids at the C-2 position to produce 2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis (PubMed:15337768, PubMed:15863841, PubMed:17355976, PubMed:22517924). FA2H is stereospecific for the production of (R)-2-hydroxy fatty acids (PubMed:22517924). Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath (By similarity). Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier (PubMed:17355976). Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis (By similarity). Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Fatty Acid 2-Hydroxylase and 2-Hydroxylated Sphingolipids: Metabolism and Function in Health and Diseases. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Late differentiation-linked increases in FA2H expression are essential for epidermal permeability barrier homeostasis., [RefSeq, PubMed]; The first reports of FA2H-associated neurodegeneration from two unrelated Iranian families., [RefSeq, PubMed]; The human FA2H gene encodes a fatty acid 2-hydroxylase involved in the formation of myelin 2-hydroxy galactosylceramides and -sulfatides, [RefSeq, PubMed]; This gene encodes a protein that catalyzes the synthesis of 2-hydroxysphingolipids, a subset of sphingolipids that contain 2-hydroxy fatty acids. Sphingolipids play roles in many cellular processes and their structural diversity arises from modification of the hydrophobic ceramide moiety, such as by 2-hydroxylation of the N-acyl chain, and the existence of many different head groups. Mutations in this gene have been associated with leukodystrophy dysmyelinating with spastic paraparesis with or without dystonia.[provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z8T6;O75213;Q96DK1;Q9H1A5",
        "ec_number_list": [
            {
                "id": "1.14.18.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.18.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005506 iron ion binding;GO:0020037 heme binding;GO:0080132 fatty acid 2-hydroxylase activity;GO:0120520 free fatty acid 2-hydroxylase activity;GO:0120521 4-hydroxysphinganine ceramide fatty acyl 2-hydroxylase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0046513 ceramide biosynthetic process;GO:0061436 establishment of skin barrier;GO:0006633 fatty acid biosynthetic process;GO:0030148 sphingolipid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 8.3,
        "record_id": "Q7L5A8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TCE6-1",
        "uniprot_id": [
            {
                "id": "DEN10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TCE6",
                "type": "external"
            }
        ],
        "mass": 40513.0,
        "length": 357,
        "protein_name": "DENN domain-containing protein 10",
        "gene_name": "DENND10",
        "organism": "Human",
        "refseq_name": "DENN domain-containing protein 10 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001290040",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001290040",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "DENND10; FAM45A",
        "gene_names_refseq": "DENND10; FAM45A",
        "protein_names_uniprotkb": "DENN domain-containing protein 10; Protein FAM45A",
        "protein_names_refseq": "DENN domain-containing protein 10 isoform 2; DENN domain-containing protein 10; family with sequence similarity 45 member A; protein FAM45A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:404636)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "11237011;18491316;23481700;25576301;28514659;28832583;28904123;29242379;30771381;32157095;32488085;32502341;32897882;32938616;33968037;34087483;34171305;34357683;35051231;35580925;36010968;36241641;37172566;38459129",
        "class_list": "",
        "function": "FAM45A defines a novel regulatory step in the homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as Rab27a/b., [RefSeq, PubMed]; Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B (PubMed:38459129). Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP-bound form (PubMed:30771381, PubMed:38459129)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AMV6;B4DDC3;D3DRC8;Q9NXW4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005770 late endosome;GO:0010008 endosome membrane",
        "go_biological_process": "GO:2000641 regulation of early endosome to late endosome transport;GO:0015031 protein transport;GO:0032456 endocytic recycling;GO:0032509 endosome transport via multivesicular body sorting pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q8TCE6-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TCP9-1",
        "uniprot_id": [
            {
                "id": "F200A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TCP9",
                "type": "external"
            }
        ],
        "mass": 66276.0,
        "length": 573,
        "protein_name": "Protein FAM200A",
        "gene_name": "FAM200A",
        "organism": "Human",
        "refseq_name": "protein FAM200A",
        "refseq_ac": [
            {
                "id": "NP_659802",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659802",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM200A; C7orf38",
        "gene_names_refseq": "C7orf38; FAM200A; ZBED8L",
        "protein_names_uniprotkb": "Protein FAM200A",
        "protein_names_refseq": "family with sequence similarity 200 member A; protein FAM200A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:221786)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "11237011;26992070;28228285;28834231;29769354;31844290;32387766;32502341;32897882;32938616;33592498;33968037;34087483;34171305;34509645;35051231",
        "class_list": "",
        "function": "This gene encodes a protein of unknown function. The protein is weakly similar to transposase-like proteins in human and mouse. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D293;A8K3V9;B2RD92;C9J6A8;D6W5T2;Q8N9P3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q8TCP9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14642-1",
        "uniprot_id": [
            {
                "id": "I5P1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14642",
                "type": "external"
            }
        ],
        "mass": 47820.0,
        "length": 412,
        "protein_name": "Inositol polyphosphate-5-phosphatase A",
        "gene_name": "INPP5A",
        "organism": "Human",
        "refseq_name": "inositol polyphosphate-5-phosphatase A isoform b",
        "refseq_ac": [
            {
                "id": "NP_001307971",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307971",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "INPP5A; 5PTASE",
        "gene_names_refseq": "5PTASE; INPP5A",
        "protein_names_uniprotkb": "Inositol polyphosphate-5-phosphatase A; 3.1.3.56; 43 kDa inositol polyphosphate 5-phosphatase; 5PTase; Type I inositol 1,4,5-trisphosphate 5-phosphatase",
        "protein_names_refseq": "43 kDa inositol polyphosphate 5-phophatase; 43 kDa inositol polyphosphate 5-phosphatase; CTCL tumor antigen HD-CL-02; InsP3 5-phosphatase; inositol polyphosphate-5-phosphatase A isoform b; inositol polyphosphate-5-phosphatase, 40kDa; inositol polyphosphate-5-phosphatase, 40kD; inositol trisphosphate-5-phosphatase, 40kD; type I inositol 1,4,5-trisphosphate 5-phosphatase; type I inositol-1,4,5-trisphosphate 5-phophatase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3632);  (R-HSA-1855183)",
        "pathway_count": 2,
        "publication_count": 46,
        "publication_id_list": "10593988;11237011;12890864;1377913;15024000;15474001;15504367;17068342;1718960;18364358;20876729;25880248;26051944;26154972;26992070;27397612;27846572;27862975;28832583;28834231;28904123;29242379;29557506;29632711;29789417;31217245;31844290;32157095;32357974;32387766;32983136;33592498;33912179;35051231;35580925;40969890;7608176;7721860;7761412;8006039;8013665;8390685;8626616;8769125;9295334;9430698",
        "class_list": "",
        "function": "NPP5Amay play a role in development and progression of cutaneous squamous cell carcinoma tumors, [RefSeq, PubMed]; Phosphatase that specifically hydrolyzes the 5-phosphate of inositol 1,4,5-trisphosphate to inositol 1,4-bisphosphate, and inositol 1,3,4,5-tetrasphosphate to inositol 1,3,4-trisphosphate (PubMed:40969890, PubMed:8013665, PubMed:8626616, PubMed:8769125). Plays a crucial role in the survival of cerebellar Purkinje cells (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; The ataxic phenotype and characteristics neurodegeneration of the Inpp5a Gt(OST50073)Lex mouse indicate a crucial role for Inpp5a in purkinje cells survival., [RefSeq, PubMed]; The protein encoded by this gene is a membrane-associated type I inositol 1,4,5-trisphosphate (InsP3) 5-phosphatase. InsP3 5-phosphatases hydrolyze Ins(1,4,5)P3, which mobilizes intracellular calcium and acts as a second messenger mediating cell responses to various stimulation. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DXI3;Q14640;Q5JSF1",
        "ec_number_list": [
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.95",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.95",
                "type": "external"
            },
            {
                "id": "3.1.3.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.36",
                "type": "external"
            },
            {
                "id": "3.1.3.64",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.64",
                "type": "external"
            },
            {
                "id": "3.1.3.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.56",
                "type": "external"
            },
            {
                "id": "3.1.3.86",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.86",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042731 PH domain binding;GO:0004445 inositol-polyphosphate 5-phosphatase activity;GO:0052658 inositol-1,4,5-trisphosphate 5-phosphatase activity;GO:0052659 inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030425 dendrite",
        "go_biological_process": "GO:0050849 negative regulation of calcium-mediated signaling;GO:0046856 phosphatidylinositol dephosphorylation;GO:1900737 negative regulation of phospholipase C-activating G protein-coupled receptor signaling pathway;GO:0043647 inositol phosphate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q14642-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZMS7-2",
        "uniprot_id": [
            {
                "id": "ZN783_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZMS7",
                "type": "external"
            }
        ],
        "mass": 61014.0,
        "length": 546,
        "protein_name": "Zinc finger protein 783",
        "gene_name": "ZNF783",
        "organism": "Human",
        "refseq_name": "zinc finger protein 783",
        "refseq_ac": [
            {
                "id": "NP_001182149",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182149",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZNF783",
        "gene_names_refseq": "ZNF783",
        "protein_names_uniprotkb": "Zinc finger protein 783",
        "protein_names_refseq": "protein ZNF783; zinc finger family member 783; zinc finger protein 783",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100289678)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "22464252;27920218;28063628;28832583;29393594;29632046;30315122;30524438;31998317",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9J9J2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q6ZMS7-2",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P69891-1",
        "uniprot_id": [
            {
                "id": "HBG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P69891",
                "type": "external"
            }
        ],
        "mass": 16128.0,
        "length": 147,
        "protein_name": "Hemoglobin subunit gamma-1",
        "gene_name": "HBG1; HBG2",
        "organism": "Human",
        "refseq_name": "hemoglobin subunit gamma-1",
        "refseq_ac": [
            {
                "id": "NP_000550",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000550",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HBG1; HBG2; HBG2; PRO2979",
        "gene_names_refseq": "HBG-T2; HBG1; HBGA; HBGR; HSGGL1; PRO2979",
        "protein_names_uniprotkb": "Hemoglobin subunit gamma-1; Gamma-1-globin; Hb F Agamma; Hemoglobin gamma-1 chain; Hemoglobin gamma-A chain",
        "protein_names_refseq": "A-gamma globin; fetal hemoglobin F subunit gamma 1; gamma A hemoglobin; gamma globin; gamma-1-globin; hb F Agamma; hemoglobin gamma-1 chain; hemoglobin gamma-a chain; hemoglobin subunit gamma-1; hemoglobin, gamma A; hemoglobin, gamma, regulator of",
        "tax_id": 9606,
        "disease": "delta beta-thalassemia (Disease Ontology:DOID:0080773)",
        "pathway": " (hsa:3047);  (R-HSA-983231)",
        "pathway_count": 2,
        "publication_count": 74,
        "publication_id_list": "11042108;11062261;11237011;11242053;1138921;11514664;11744692;11751636;11895428;11950885;12032298;12134158;12427746;15020713;15247287;15710388;16054028;16131492;1630448;17027967;1703137;17196961;1802881;19293402;20530532;20627800;20925047;21747884;218813;22096240;23186163;2411679;2417989;2419280;2448268;2448269;2454900;2467893;2581920;26845023;3409321;34406845;34535703;34569056;35138035;37217939;38218889;4455303;4765089;5491586;5554303;6019034;6038320;6163752;6175602;6183236;6186637;6188719;6197997;6198905;6199326;7332928;7438203;7690768;7928382;808940;8662638;8816476;9065479;9230307;9326583;9331217;9422515;9927674",
        "class_list": "",
        "function": "Activation of gamma-globin expression by LncRNA-mediated ERF promoter hypermethylation in beta-thalassemia. Publication Status: Online-Only, [RefSeq, PubMed]; Drug Repurposing: Hydroxyurea Therapy Improves the Transfusion-Free Interval in HbE/Beta-Thalassemia-Major Patients with the XmnI Polymorphism., [RefSeq, PubMed]; Gamma chains make up the fetal hemoglobin F, in combination with alpha chains., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Joint efficacy of the three biomarkers SNCA, GYPB and HBG1 for atrial fibrillation and stroke: Analysis via the support vector machine neural network., [RefSeq, PubMed]; Novel variants in Krueppel like factor 1 that cause persistence of fetal hemoglobin in In(Lu) individuals. Publication Status: Online-Only, [RefSeq, PubMed]; TEA domain transcription factor 4 modulates repression of fetal haemoglobin by direct binding to the gamma-globin gene promoters., [RefSeq, PubMed]; The gamma globin genes (HBG1 and HBG2) are normally expressed in the fetal liver, spleen and bone marrow. Two gamma chains together with two alpha chains constitute fetal hemoglobin (HbF) which is normally replaced by adult hemoglobin (HbA) at birth. In some beta-thalassemias and related conditions, gamma chain production continues into adulthood. The two types of gamma chains differ at residue 136 where glycine is found in the G-gamma product (HBG2) and alanine is found in the A-gamma product (HBG1). The former is predominant at birth. The order of the genes in the beta-globin cluster is: 5'-epsilon -- gamma-G -- gamma-A -- delta -- beta--3'. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
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        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P02096;P62027;Q549G1;Q8TDA1;Q96FH7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0031721 hemoglobin alpha binding;GO:0019825 oxygen binding;GO:0005344 oxygen carrier activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005833 hemoglobin complex;GO:0031838 haptoglobin-hemoglobin complex",
        "go_biological_process": "GO:0015670 carbon dioxide transport;GO:0048821 erythrocyte development;GO:0015671 oxygen transport",
        "synthesized_glycan_count": 0,
        "hit_score": 7.7,
        "record_id": "P69891-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96A26-1",
        "uniprot_id": [
            {
                "id": "F162A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96A26",
                "type": "external"
            }
        ],
        "mass": 17342.0,
        "length": 154,
        "protein_name": "Protein FAM162A",
        "gene_name": "FAM162A",
        "organism": "Human",
        "refseq_name": "protein FAM162A",
        "refseq_ac": [
            {
                "id": "NP_055182",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055182",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM162A; C3orf28; DC16; E2IG5; FWP001",
        "gene_names_refseq": "C3orf28; E2IG5; FAM162A; HGTD-P",
        "protein_names_uniprotkb": "Protein FAM162A; E2-induced gene 5 protein; Growth and transformation-dependent protein; HGTD-P",
        "protein_names_refseq": "E2-induced gene 5 protein; HIF-1 alpha-responsive proapoptotic molecule; growth and transformation-dependent protein; protein FAM162A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26355)",
        "pathway_count": 1,
        "publication_count": 44,
        "publication_id_list": "11085516;11237011;15082785;16698020;18507432;18991276;19269009;20840676;20877624;23481700;24714562;24715725;25576301;26375851;26728094;26992070;27452731;27862975;28063628;28510447;28832583;28834231;29242379;29393594;29493099;29508533;29557506;29632046;30833945;31154438;31530632;31844290;31848261;32157095;32161166;32502341;32897882;32938616;32983136;33141586;33717175;33968037;35580925;36010968",
        "class_list": "",
        "function": "Data indicate that HGTD-P is a new hypoxia-inducible factor 1 alpha-responsive proapoptotic molecule that activates mitochondrial apoptotic cascades., [RefSeq, PubMed]; Expression and clinicopathological significance of human growth and transformation-dependent protein (HGTD-P) in uterine cervical cancer, [RefSeq, PubMed]; Heat shock protein 90 physically interacts with HGTD-P., [RefSeq, PubMed]; Human growth and transformation-dependent protein expression is a common occurrence during the progression from a normal gastric mucosa to an intestinal-type carcinoma and may be associated with tumor cell proliferation activity, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Proposed to be involved in regulation of apoptosis; the exact mechanism may differ between cell types/tissues (PubMed:15082785). May be involved in hypoxia-induced cell death of transformed cells implicating cytochrome C release and caspase activation (such as CASP9) and inducing mitochondrial permeability transition (PubMed:15082785). May be involved in hypoxia-induced cell death of neuronal cells probably by promoting release of AIFM1 from mitochondria to cytoplasm and its translocation to the nucleus; however, the involvement of caspases has been reported conflictingly (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "secondary_ac_list": "Q9NRN6;Q9UJX8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0051402 neuron apoptotic process;GO:0071456 cellular response to hypoxia;GO:0090200 positive regulation of release of cytochrome c from mitochondria",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q96A26-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
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    },
    {
        "uniprot_canonical_ac": "P78385-1",
        "uniprot_id": [
            {
                "id": "KRT83_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P78385",
                "type": "external"
            }
        ],
        "mass": 54195.0,
        "length": 493,
        "protein_name": "Keratin, type II cuticular Hb3",
        "gene_name": "KRT83",
        "organism": "Human",
        "refseq_name": "keratin, type II cuticular Hb3",
        "refseq_ac": [
            {
                "id": "NP_002273",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002273",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KRT83; KRTHB3",
        "gene_names_refseq": "EKVP5; HB3; Hb-3; KRT83; KRTHB3; MNLIX3; MNLIX",
        "protein_names_uniprotkb": "Keratin, type II cuticular Hb3; Hair keratin K2.10; K83; Keratin-83; Type II hair keratin Hb3; Type-II keratin Kb23; hHb3",
        "protein_names_refseq": "K83; hHb3; hair keratin K2.10; hard keratin, type II, 3; keratin 83, type II; keratin, hair, basic, 3; keratin, type II cuticular Hb3; type II hair keratin Hb3; type-II keratin Kb23",
        "tax_id": 9606,
        "disease": "monilethrix 3 (Disease Ontology:DOID:0061153); erythrokeratodermia variabilis et progressiva 5 (Disease Ontology:DOID:0080251)",
        "pathway": " (hsa:3889);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 3,
        "publication_count": 54,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10692104;10771479;11350120;11380615;11445569;11590230;12902340;15033990;15337775;15373777;15744029;15797384;15797458;15803139;16061697;16382671;16639001;1691188;1694855;1714783;17515931;17521629;17562024;17596512;18843291;19190773;19194479;20179351;20657595;20667819;20940292;21439340;21654840;21997417;23481192;23629652;2414304;25208914;25557232;25926655;26390218;27965375;7543090;8824274;8999895;9084137;9395522;9468612;9565599",
        "class_list": "",
        "function": "A heterozygous missense mutation in hHb3 causing the substitution of a glutamic acid by a lysine at position 407 in the helix termination motif defines this particular residue as a trichocyte keratin mutational hotspot associated with monilethrix., [RefSeq, PubMed]; Novel mutations causing monilethrix are reported in KRT81, KRT83, and KRT86., [RefSeq, PubMed]; Our findings indicate that at least some cases of autosomal recessive Progressive symmetric erythrokeratoderma (PSEK)and autosomal dominant monilethrix are allelic, respectively resulting from loss-of-function and missense mutations in the KRT83 gene, [RefSeq, PubMed]; Structural component of intermediate filaments in the hair cortex (PubMed:15744029, PubMed:25557232). Forms obligate heterodimers with type I hair keratins, which assemble into keratin intermediate filaments that contribute to the structural integrity and mechanical strength of the hair shaft (PubMed:15744029, PubMed:25557232)., [UniProtKB, PubMed, PubMed]; The KRTHB3 expression uniformly occurred in the midcortex region. Review article, [RefSeq, PubMed]; The protein encoded by this gene is a member of the keratin gene family. As a type II hair keratin, it is a basic protein which heterodimerizes with type I keratins to form hair and nails. The type II hair keratins are clustered in a region of chromosome 12q13 and are grouped into two distinct subfamilies based on structure similarity. One subfamily, consisting of KRTHB1, KRTHB3, and KRTHB6, is highly related. The other less-related subfamily includes KRTHB2, KRTHB4, and KRTHB5. All hair keratins are expressed in the hair follicle; this hair keratin, as well as KRTHB1 and KRTHB6, is found primarily in the hair cortex. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A4S9;B2RC21;Q6NT21;Q9NSB3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030280 structural constituent of skin epidermis",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0045095 keratin filament",
        "go_biological_process": "GO:0031424 keratinization;GO:0008544 epidermis development;GO:0045109 intermediate filament organization;GO:0042633 hair cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "P78385-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IYM0-1",
        "uniprot_id": [
            {
                "id": "F186B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IYM0",
                "type": "external"
            }
        ],
        "mass": 103722.0,
        "length": 893,
        "protein_name": "Protein FAM186B",
        "gene_name": "FAM186B",
        "organism": "Human",
        "refseq_name": "protein FAM186B",
        "refseq_ac": [
            {
                "id": "NP_115506",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115506",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM186B; C12orf25",
        "gene_names_refseq": "C12orf25; FAM186B",
        "protein_names_uniprotkb": "Protein FAM186B",
        "protein_names_refseq": "protein FAM186B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84070)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11230166;11237011;28832583;29557506;32387766;33537174;36215666;37074911",
        "class_list": "",
        "function": "This gene product is a member of the FAM186 family, however, its exact function is not known. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 9718,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DZ15;Q8TCP7;Q9H0L3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0032991 protein-containing complex",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8IYM0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9ULI3-1",
        "uniprot_id": [
            {
                "id": "HEG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9ULI3",
                "type": "external"
            }
        ],
        "mass": 147461.0,
        "length": 1381,
        "protein_name": "Protein HEG homolog 1",
        "gene_name": "HEG1",
        "organism": "Human",
        "refseq_name": "protein HEG homolog 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_065784",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065784",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEG1; KIAA1237",
        "gene_names_refseq": "HEG1; HEG; MST112; MSTP112",
        "protein_names_uniprotkb": "Protein HEG homolog 1",
        "protein_names_refseq": "heart of glass; protein HEG homolog 1 precursor; protein HEG homolog 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57493)",
        "pathway_count": 1,
        "publication_count": 60,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;11237011;14680629;16335952;22171320;23007647;23090970;23481700;23584533;23814056;24190977;24643410;24715725;25502872;25576301;25645385;25813380;26992070;27920218;28228285;28446606;28649982;28832583;28904123;29242379;29391424;29393594;29508533;29557506;29632046;30407017;30429286;30459171;31092671;31217245;31844290;32157095;32284171;32350084;32387766;32938616;32983136;33298915;33592498;33717175;33774129;33912179;33968037;34240508;34357683;34411563;35051231;35154160;35561310;36010968;37074911;38099436;38665916",
        "class_list": "",
        "function": "HEG1 Protects Against Atherosclerosis by Regulating Stable Flow-Induced KLF2/4 Expression in Endothelial Cells., [RefSeq, PubMed]; HEG1-responsive microRNA-23b regulates cell proliferation in malignant mesothelioma cells., [RefSeq, PubMed]; Human patients with cerebral cavernous malformations who lack exonic mutations in krev interaction trapped protein (KRIT)1, cerebral cavernous malformation (CCM) protein 2, or programmed cell death (PDCD)10 protein do not have mutations in HEG., [RefSeq, PubMed]; Identification of the zebrafish heart of glass (heg) gene. Description of HEG's role in the regulation of concentric heart growth in zebrafish., [RefSeq, PubMed]; LncRNA SNHG12 promotes proliferation and epithelial mesenchymal transition in hepatocellular carcinoma through targeting HEG1 via miR-516a-5p., [RefSeq, PubMed]; Membranous HEG1 expression is a useful marker in the differential diagnosis of epithelioid and biphasic malignant mesothelioma versus carcinomas., [RefSeq, PubMed]; Receptor component of the CCM signaling pathway which is a crucial regulator of heart and vessel formation and integrity. May act through the stabilization of endothelial cell junctions., [UniProtKB]; These data show that HEG1 can recruit the Rap1-KRIT complex to the plasma membrane., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 11,
        "reported_o_glycosites_with_glycan": 107,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 12,
        "total_reported_o_glycosites": 107,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 12,
        "total_o_glycosites": 107,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 164,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 32,
        "disease_count": 0,
        "glyco_site_count": 122,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NX66;Q8NC40;Q9BSV0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005911 cell-cell junction;GO:0009897 external side of plasma membrane;GO:0005886 plasma membrane",
        "go_biological_process": "GO:2000299 negative regulation of Rho-dependent protein serine/threonine kinase activity;GO:0007507 heart development;GO:0035024 negative regulation of Rho protein signal transduction;GO:1902414 protein localization to cell junction;GO:1905709 negative regulation of membrane permeability",
        "synthesized_glycan_count": 0,
        "hit_score": 21.2,
        "record_id": "Q9ULI3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43719-1",
        "uniprot_id": [
            {
                "id": "HTSF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43719",
                "type": "external"
            }
        ],
        "mass": 85853.0,
        "length": 755,
        "protein_name": "17S U2 SnRNP complex component HTATSF1",
        "gene_name": "HTATSF1",
        "organism": "Human",
        "refseq_name": "17S U2 SnRNP complex component HTATSF1",
        "refseq_ac": [
            {
                "id": "NP_001156752",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156752",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HTATSF1",
        "gene_names_refseq": "HTATSF1; TAT-SF1; TATSF1; dJ196E23.2",
        "protein_names_uniprotkb": "17S U2 SnRNP complex component HTATSF1; HIV Tat-specific factor 1; Tat-SF1",
        "protein_names_refseq": "17S U2 SnRNP complex component HTATSF1; HIV TAT specific factor 1; HIV Tat-specific factor 1; cofactor required for Tat activation of HIV-1 transcription",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27336);  (R-HSA-72163);  (R-HSA-9770562)",
        "pathway_count": 3,
        "publication_count": 211,
        "publication_id_list": "10.1101/2023.09.13.557529;10393184;10454543;10669729;10882114;10913173;11014198;11060040;11101529;11233976;11237011;11420046;11780068;11991638;12176931;12411573;12414731;12477934;14625303;14713954;14749727;15037765;15345747;15485897;15565158;15905670;16314458;16565220;16809785;17081983;17095540;17128255;17287340;17322306;17332742;17525332;17606899;18212344;18288197;18318008;18322460;18452278;18593880;18669648;18767875;19007248;19103666;19165350;19217410;19413330;19536130;19651622;19664994;19664995;19690332;19691289;20058876;20068231;20112406;20166139;20423332;20695905;20980672;21295486;21406692;21536652;2176635;22110043;22223895;22365833;22424782;22813749;22959432;22961380;23186163;23222130;23236153;23301498;23345524;23481700;23874216;24076191;24149845;24196718;24275569;24304693;24448447;24715725;24737827;24914973;25301780;25301781;25418920;25469497;25505266;25555158;25576301;2558966;25892735;26154972;26385511;26420826;26811146;26969736;26992070;27377154;27459055;27683217;27846572;27862975;27920218;28062851;28063628;28076346;28096519;28502770;28510447;28514659;28781166;28832583;28904123;28911096;29186539;29242379;29274231;29301961;29360106;29361316;29393594;29493099;29557506;29632046;2963332;29769354;29786170;30139799;30257008;30315277;30379171;30429286;30524438;30567737;30705154;30728453;30765414;30779550;30975767;31154438;31409651;31844290;31848261;32119511;32157095;32179686;32265295;32329775;32357974;32387766;32488085;32494006;32502341;32816001;32897882;32938616;32983136;33141586;33243851;33298915;33446560;33592498;33912179;33968037;33981976;34019948;34171305;34301950;34405274;34509645;34561969;34822310;34932366;35051231;35154160;35177536;35318648;35385551;35561310;35580925;35597237;36797247;3757028;37938771;39302247;39894887;40307207;40914422;8566756;8608946;8849451;9016565;9242493;9512519;9524131;9539711;9649438;9659921;9671485;9701291;9710584;9731529;9765201",
        "class_list": "",
        "function": "(Microbial infection) In case of infection by HIV-1, it is up-regulated by the HIV-1 proteins NEF and gp120, acts as a cofactor required for the Tat-enhanced transcription of the virus., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Component of the 17S U2 SnRNP complex of the spliceosome, a large ribonucleoprotein complex that removes introns from transcribed pre-mRNAs (PubMed:30567737, PubMed:32494006, PubMed:34822310). The 17S U2 SnRNP complex (1) directly participates in early spliceosome assembly and (2) mediates recognition of the intron branch site during pre-mRNA splicing by promoting the selection of the pre-mRNA branch-site adenosine, the nucleophile for the first step of splicing (PubMed:30567737, PubMed:32494006, PubMed:34822310). Within the 17S U2 SnRNP complex, HTATSF1 is required to stabilize the branchpoint-interacting stem loop (PubMed:34822310). HTATSF1 is displaced from the 17S U2 SnRNP complex before the stable addition of the 17S U2 SnRNP complex to the spliceosome, destabilizing the branchpoint-interacting stem loop and allowing to probe intron branch site sequences (PubMed:32494006, PubMed:34822310). Also acts as a regulator of transcriptional elongation, possibly by mediating the reciprocal stimulatory effect of splicing on transcriptional elongation (PubMed:10454543, PubMed:10913173, PubMed:11780068). Involved in double-strand break (DSB) repair via homologous recombination in S-phase by promoting the recruitment of TOPBP1 to DNA damage sites (PubMed:35597237). Mechanistically, HTATSF1 is (1) recruited to DNA damage sites in S-phase via interaction with poly-ADP-ribosylated RPA1 and (2) phosphorylated by CK2, promoting recruitment of TOPBP1, thereby facilitating RAD51 nucleofilaments formation and RPA displacement, followed by homologous recombination (PubMed:35597237)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene functions as a cofactor for the stimulation of transcriptional elongation by HIV-1 Tat, which binds to the HIV-1 promoter through Tat-TAR interaction. This protein may also serve as a dual-function factor to couple transcription and splicing and to facilitate their reciprocal activation. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 42,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DWG9;Q59G06;Q99730",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0140463 chromatin-protein adaptor activity;GO:0160004 poly-ADP-D-ribose modification-dependent protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0005686 U2 snRNP;GO:0005684 U2-type spliceosomal complex",
        "go_biological_process": "GO:1990166 protein localization to site of double-strand break;GO:0006351 DNA-templated transcription;GO:0000724 double-strand break repair via homologous recombination;GO:0000398 mRNA splicing, via spliceosome;GO:1903241 U2-type prespliceosome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 21.6,
        "record_id": "O43719-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P20810-1",
        "uniprot_id": [
            {
                "id": "ICAL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P20810",
                "type": "external"
            }
        ],
        "mass": 76573.0,
        "length": 708,
        "protein_name": "Calpastatin",
        "gene_name": "CAST",
        "organism": "Human",
        "refseq_name": "calpastatin isoform f",
        "refseq_ac": [
            {
                "id": "NP_001035905",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035905",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CAST",
        "gene_names_refseq": "BS-17; CAST; MIR583HG; PLACK",
        "protein_names_uniprotkb": "Calpastatin; Calpain inhibitor; Sperm BS-17 component",
        "protein_names_refseq": "MIR583 host; calpain inhibitor; calpastatin isoform f; sperm BS-17 component",
        "tax_id": 9606,
        "disease": "stroke (Disease Ontology:DOID:0051061); PLACK syndrome (Disease Ontology:DOID:0070526); congenital myasthenic syndrome 1A (Disease Ontology:DOID:0110663); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); Sjogren's syndrome (Disease Ontology:DOID:12894); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); Parkinson's disease (Disease Ontology:DOID:14330); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); rheumatoid arthritis (Disease Ontology:DOID:7148); muscular atrophy (Disease Ontology:DOID:767); vasculitis (Disease Ontology:DOID:865); psoriasis (Disease Ontology:DOID:8893); systemic lupus erythematosus (Disease Ontology:DOID:9074); pemphigus (Disease Ontology:DOID:9182); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:831);  (R-HSA-1474228);  (R-HSA-8862803)",
        "pathway_count": 3,
        "publication_count": 132,
        "publication_id_list": "10229672;10386589;10604467;10639123;10706100;10809722;10830966;10986281;11375993;11853546;11872628;11978196;12727852;12843408;14973287;15234972;15590058;15591058;1569094;15958533;16133547;16408927;1649600;16631740;16825321;1698775;1707285;17081983;17287340;17324966;17332331;17354228;17608959;18434311;18452278;18491316;18658137;18669648;18691386;18707149;19010778;19413330;19415658;19571574;19651622;19657146;19664994;19714641;1995645;20068231;20142769;20166139;21030783;21297635;21441952;21670566;21784848;21864727;22159414;22544926;22899714;23035980;23186163;23301498;23481700;23845380;2407243;24275569;24715725;25218447;2553724;25576301;25645385;25683118;2577276;27626661;27862975;28657654;29557506;31154438;31373491;31637018;31844290;31848261;31937595;31998317;32157095;32161166;32350084;32387766;32488085;32502341;32938616;32938750;32983136;33141586;33592498;33968037;34019948;34087483;34171305;34191270;34440632;34509645;35008409;35051231;35254053;35289036;35561310;35580925;36010968;36215666;37217939;37316325;37340703;37387535;38838015;39186261;39531497;7075587;7547873;7698360;7706496;7951045;8226919;8626565;9065415;9115292;9148753;9228946;9461298;9852107",
        "class_list": "",
        "function": "Critical Roles of Calpastatin in Ischemia/Reperfusion Injury in Aged Livers. Publication Status: Online-Only, [RefSeq, PubMed]; Gene-Environment Interaction Between CAST Gene and Eye-Rubbing in the Chinese Keratoconus Cohort Study: A Case-Only Study., [RefSeq, PubMed]; Novel nonsense CAST mutation in two siblings with PLACK syndrome., [RefSeq, PubMed]; Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue., [UniProtKB]; The protein encoded by this gene is an endogenous calpain (calcium-dependent cysteine protease) inhibitor. It consists of an N-terminal domain L and four repetitive calpain-inhibition domains (domains 1-4), and it is involved in the proteolysis of amyloid precursor protein. The calpain/calpastatin system is involved in numerous membrane fusion events, such as neural vesicle exocytosis and platelet and red-cell aggregation. The encoded protein is also thought to affect the expression levels of genes encoding structural or regulatory proteins. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Jun 2010]., [RefSeq]; Variants in Genes of Calpain System as Modifiers of Spinocerebellar Ataxia Type 3 Phenotype., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 33,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 17,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z468;G5E946;G5E9D3;O95360;Q05DE8;Q7Z4K0;Q96D08;Q9H1Z5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0045296 cadherin binding;GO:0004866 endopeptidase inhibitor activity;GO:0010859 calcium-dependent cysteine-type endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:1990709 presynaptic active zone organization;GO:2000675 negative regulation of type B pancreatic cell apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 14.1,
        "record_id": "P20810-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9XRX5-4",
        "uniprot_id": [
            {
                "id": "HHLA3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9XRX5",
                "type": "external"
            }
        ],
        "mass": 12913.0,
        "length": 114,
        "protein_name": "Putative uncharacterized protein ANKRD13C-DT",
        "gene_name": "ANKRD13C-DT",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "ANKRD13C-DT; HHLA3",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein ANKRD13C-DT; ANKRD13C divergent transcript; HERV-H LTR-associating protein 3; Human endogenous retrovirus-H long terminal repeat-associating protein 3",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 13,
        "publication_id_list": "10444326;25418920;26154972;26811146;26929215;26992070;27846572;27862975;28063628;29393594;29632046;31844290;35580925",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "D3DQ74;Q5VZP2;Q96FH5;Q9XRX4",
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        "hit_score": 1.4,
        "record_id": "Q9XRX5-4",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P14866-1",
        "uniprot_id": [
            {
                "id": "HNRPL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P14866",
                "type": "external"
            }
        ],
        "mass": 64133.0,
        "length": 589,
        "protein_name": "Heterogeneous nuclear ribonucleoprotein L",
        "gene_name": "HNRNPL",
        "organism": "Human",
        "refseq_name": "heterogeneous nuclear ribonucleoprotein L isoform b",
        "refseq_ac": [
            {
                "id": "NP_001005335",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001005335",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HNRNPL; HNRPL; OKcl.14",
        "gene_names_refseq": "HNRNPL; HNRPL; P/OKcl.14; hnRNP-L",
        "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein L; hnRNP L",
        "protein_names_refseq": "epididymis secretory sperm binding protein; heterogeneous nuclear ribonucleoprotein L isoform b; hnRNP L",
        "tax_id": 9606,
        "disease": "Sertoli cell-only syndrome (Disease Ontology:DOID:0050457); brain cancer (Disease Ontology:DOID:1319); lung cancer (Disease Ontology:DOID:1324); systemic scleroderma (Disease Ontology:DOID:418); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:3191);  (R-HSA-72163);  (R-HSA-72203);  (R-HSA-9770562);  (R-HSA-9918481)",
        "pathway_count": 5,
        "publication_count": 276,
        "publication_id_list": "10513815;10669729;10882114;11014198;11060040;11101529;11233976;11237011;11280764;11747608;11809897;11991638;12176931;12411573;12414731;12477934;1286667;14519844;14625303;14713954;14720331;14749727;14762106;15037765;15084397;15104674;15129427;15565158;16314458;16809785;17095540;17128255;17287340;17289661;17332742;17606899;18161049;18288197;18322460;18452278;18593880;18669648;18669861;18991276;19103666;19124611;19165350;19217410;19332550;19413330;19536130;19608861;19651622;19689476;20068231;20112406;20128819;20305658;20423332;20695905;20980672;21295486;21406692;21536652;21740066;2176635;21911577;21932426;22110043;22365833;22544926;22570490;22813749;22959432;22961380;22967762;23186163;23222130;23236153;23345524;23782695;23783831;23874216;23976881;24076191;24149845;24164894;24196718;24304693;24316715;24366607;24407421;24448447;24714562;24715725;24737827;24914973;24981863;24992895;25218447;25301780;25301781;25469497;25555158;25576301;2558966;25623890;25662406;25755297;25772364;25802875;25880248;26051023;26092250;26154972;26212219;26385511;26420826;26853435;2687284;26969736;26992070;27108190;27377154;27459055;27503676;27600516;27655845;27683217;27703488;27846572;27862975;27920218;28062851;28063628;28076346;28096519;28188670;28218747;28228285;28416261;28502770;28514659;28520992;28622427;28649982;28781166;28832583;28834231;28855257;28860189;28904123;28911096;29186539;29242379;29274231;29301961;29331515;29360106;29361316;29393594;29437277;29493099;29508533;29557506;29632046;29632711;2963332;29769354;29786170;29789417;29902443;29938870;30139799;30192525;30257008;30315122;30315277;30397120;30410026;30444036;30484775;30524438;30599162;30705154;30728453;30765414;30833945;30975767;31154438;31217245;31409651;31844290;32119511;32157095;32179686;32236612;32265295;32329775;32350084;32357974;32387766;32488085;32494006;32502341;32816001;32897882;32938616;32983136;33123756;33141586;33174841;33177556;33214551;33243851;33298915;33392160;33437477;33446560;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34301950;34333526;34357683;34405274;34509645;34561969;34725712;34822310;34932366;35051231;35083852;35177536;35215846;35251023;35278674;35318648;35385551;35561310;35580925;35982900;36010968;36215666;36241641;36284347;36537238;36747239;37217939;3757028;37938771;38665916;40914422;8352591;8566756;8608946;9016565;9242493;9409616;9512519;9524131;9539711;9659921;9671485;9701291;9731529",
        "class_list": "",
        "function": "HNRNPL induced circFAM13B increased bladder cancer immunotherapy sensitivity via inhibiting glycolysis through IGF2BP1/PKM2 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Heterogeneous nuclear RNAs (hnRNAs) which include mRNA precursors and mature mRNAs are associated with specific proteins to form heterogenous ribonucleoprotein (hnRNP) complexes. Heterogeneous nuclear ribonucleoprotein L is among the proteins that are stably associated with hnRNP complexes and along with other hnRNP proteins is likely to play a major role in the formation, packaging, processing, and function of mRNA. Heterogeneous nuclear ribonucleoprotein L is present in the nucleoplasm as part of the HNRP complex. HNRP proteins have also been identified outside of the nucleoplasm. Exchange of hnRNP for mRNA-binding proteins accompanies transport of mRNA from the nucleus to the cytoplasm. Since HNRP proteins have been shown to shuttle between the nucleus and the cytoplasm, it is possible that they also have cytoplasmic functions. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; HnRNPL-activated circANKRD42 back-splicing and circANKRD42-mediated crosstalk of mechanical stiffness and biochemical signal in lung fibrosis., [RefSeq, PubMed]; Splicing factor binding to exonic or intronic sites and acting as either an activator or repressor of exon inclusion. Exhibits a binding preference for CA-rich elements (PubMed:11809897, PubMed:22570490, PubMed:24164894, PubMed:25623890, PubMed:26051023). Component of the heterogeneous nuclear ribonucleoprotein (hnRNP) complexes and associated with most nascent transcripts (PubMed:2687284). Associates, together with APEX1, to the negative calcium responsive element (nCaRE) B2 of the APEX2 promoter (PubMed:11809897). As part of a ribonucleoprotein complex composed at least of ZNF827, HNRNPK and the circular RNA circZNF827 that nucleates the complex on chromatin, may negatively regulate the transcription of genes involved in neuronal differentiation (PubMed:33174841). Regulates alternative splicing of a core group of genes involved in neuronal differentiation, likely by mediating H3K36me3-coupled transcription elongation and co-transcriptional RNA processing via interaction with CHD8., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The m6A-induced lncRNA CASC8 promotes proliferation and chemoresistance via upregulation of hnRNPL in esophageal squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]",
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        "secondary_ac_list": "A6ND69;A6NIT8;Q9H3P3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0097157 pre-mRNA intronic binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0045202 synapse",
        "go_biological_process": "GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0045892 negative regulation of DNA-templated transcription;GO:0043484 regulation of RNA splicing;GO:0000381 regulation of alternative mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 27.9,
        "record_id": "P14866-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N5G2-1",
        "uniprot_id": [
            {
                "id": "MACOI_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N5G2",
                "type": "external"
            }
        ],
        "mass": 76178.0,
        "length": 664,
        "protein_name": "Macoilin",
        "gene_name": "MACO1",
        "organism": "Human",
        "refseq_name": "macoilin isoform b",
        "refseq_ac": [
            {
                "id": "NP_001269493",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269493",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MACO1; TMEM57",
        "gene_names_refseq": "MACO1; MACOILIN; TMEM57",
        "protein_names_uniprotkb": "Macoilin; Macoilin-1; Transmembrane protein 57",
        "protein_names_refseq": "macoilin isoform b; transmembrane protein 57",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55219);  (R-HSA-8980692);  (R-HSA-9013106)",
        "pathway_count": 3,
        "publication_count": 207,
        "publication_id_list": "10.1101/2023.09.13.557529;10037681;10232922;10490598;10523665;10523675;10526156;10579713;10619026;10699171;10873388;11058585;11085924;11207612;11237011;11373293;11396949;11431473;11432776;11606631;11672528;11680691;11689693;11704860;11804589;11804590;11884391;11912491;12071859;12093360;12195014;12221077;12221096;12531887;12650940;12857875;12877655;14512443;15023524;15064355;15107133;15302923;15342493;15485661;15601624;15611138;15850391;15866170;16112081;16116428;16184169;16217026;16467373;16519628;16630611;16776779;16777452;16777849;16862148;16896804;16914516;17077126;17562871;17702745;17765681;17804252;17932950;17942708;17976533;18158243;18218625;18669648;18829452;19007248;19494238;19605563;19635168;19651622;19664994;19673492;19690332;19713215;20030946;20068231;20101212;20400958;20591975;20628200;20660154;21148482;21351730;21454492;21565175;21576392;21589894;21699497;21757538;21865595;21936715;22096251;22298643;22305756;22673745;22790947;22911862;22992742;23186163;23200924;23255595;23434736;23572525;23870313;24086303;24128008;24259668;24335996;24352656;24933155;25211221;25425145;25576301;25704760;25892735;26371245;26529257;26887924;27145964;27216196;27481945;27862975;27919029;27986909;28112683;28196833;28228285;28584191;28832583;28904123;29146911;29242379;29393594;29557506;29632046;29769354;29786170;30315122;30379171;30429286;31105010;31154438;31217245;31844290;31848261;31871319;32157095;32161166;32203420;32265295;32350084;32387766;32502341;32938616;32983136;33141586;33298915;33392160;33592498;33968037;35051231;35580925;36010968;37217939;37938771;39534244;40136647;7479768;7673236;7721814;7753201;8021274;8537347;8543060;8571126;8617235;8643598;8649427;8662891;8756646;8769096;8807639;8810315;8816443;8939998;9013646;9111050;9113980;9305890;9418861;9490638;9497316;9535835;9548756;9659915;9670022;9792683;9822605;9829970",
        "class_list": "",
        "function": "Plays a role in the regulation of neuronal activity., [UniProtKB, PubMed, UniProtKB, UniProtKB]; These results indicate that PAK4 confers CDDP resistance via the activation of MEK/ERK and PI3K/Akt pathways. PAK4 and PI3K/Akt pathways can reciprocally activate each other. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
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        "reported_n_glycosites": 2,
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        "reported_n_glycosites_with_glycan": 2,
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        "total_reported_n_glycosites": 2,
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        "secondary_ac_list": "B1AK00;Q2TLX5;Q2TLX6;Q9NVG6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0030424 axon;GO:0031965 nuclear membrane;GO:0045202 synapse;GO:0044306 neuron projection terminus",
        "go_biological_process": "GO:0023041 neuronal signal transduction;GO:0006935 chemotaxis;GO:0007420 brain development",
        "synthesized_glycan_count": 0,
        "hit_score": 21.8,
        "record_id": "Q8N5G2-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6P4D5-1",
        "uniprot_id": [
            {
                "id": "PBIR3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P4D5",
                "type": "external"
            }
        ],
        "mass": 22522.0,
        "length": 195,
        "protein_name": "PABIR family member 1",
        "gene_name": "PABIR3",
        "organism": "Human",
        "refseq_name": "PABIR family member 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001164250",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164250",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PABIR3; FAM122C",
        "gene_names_refseq": "FAM122C; PABIR3",
        "protein_names_uniprotkb": "PABIR family member 1",
        "protein_names_refseq": "PABIR family member 1 isoform 1; PABIR family member 1; family with sequence similarity 122C; protein FAM122C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:159091)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;28832583;29242379;29557506;29632711;30429286;30451992;32157095;32387766",
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        "secondary_ac_list": "F5H036;Q8WVK9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004865 protein serine/threonine phosphatase inhibitor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0032436 positive regulation of proteasomal ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q6P4D5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
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    },
    {
        "uniprot_canonical_ac": "Q8NFR9-1",
        "uniprot_id": [
            {
                "id": "I17RE_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NFR9",
                "type": "external"
            }
        ],
        "mass": 74810.0,
        "length": 667,
        "protein_name": "Interleukin-17 receptor E",
        "gene_name": "IL17RE",
        "organism": "Human",
        "refseq_name": "interleukin-17 receptor E isoform 6 precursor",
        "refseq_ac": [
            {
                "id": "NP_001180309",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180309",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL17RE; PRO9877",
        "gene_names_refseq": "IL17RE",
        "protein_names_uniprotkb": "Interleukin-17 receptor E; IL-17 receptor E; IL-17RE",
        "protein_names_refseq": "IL-17 receptor E; interleukin-17 receptor E isoform 6 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:132014);  (R-HSA-448424)",
        "pathway_count": 2,
        "publication_count": 19,
        "publication_id_list": "11237011;11574464;12975309;16310341;16397230;16785495;21993848;21993849;23834281;29557506;29632046;31905037;32174926;32387766;33968037;35051231;35553626;37235960;8777726",
        "class_list": "",
        "function": "Clinical significance of Interleukin 17 receptor E in diabetic nephropathy., [RefSeq, PubMed]; Evaluation of Interleukin 25 and Interleukin 25 Receptor Expression in Peripheral Blood Mononuclear Cells of Breast Cancer Patients and Normal Subjects., [RefSeq, PubMed]; IL-17C/IL-17RE: Emergence of a Unique Axis in TH17 Biology. Review article Publication Status: Online-Only, [RefSeq, PubMed]; IL-17RE as a receptor of IL-17C that regulates early innate immunity to intestinal pathogens. Publication Status: Online-Only, [RefSeq, PubMed]; Interleukin 17 receptor E identifies heterogeneous T helper 17 cells in peritoneal fluid of moderate and severe endometriosis patients., [RefSeq, PubMed]; Specific functional receptor for IL17C. May be signaling through the NF-kappa-B and MAPK pathways. May require TRAF3IP2 /ACT1 for signaling. May be a crucial regulator in innate immunity to bacterial pathogens. Isoform 2 and isoform 4 may be either cytoplasmic inactive or dominant active forms. Isoform 3 and isoform 5 may act as soluble decoy receptors., [UniProtKB, PubMed, PubMed]; This gene encodes a transmembrane protein that functions as the receptor for interleukin-17C. The encoded protein signals to downstream components of the mitogen activated protein kinase (MAPK) pathway. Activity of this protein is important in the immune response to bacterial pathogens. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2013]., [RefSeq]",
        "predicted_glycosites": 3,
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        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RB34;B2RNR1;B9EH65;Q6P532;Q8N8H7;Q8N8H8;Q8TEC2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030368 interleukin-17 receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0070534 protein K63-linked ubiquitination;GO:0072538 T-helper 17 type immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q8NFR9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7LGA3-1",
        "uniprot_id": [
            {
                "id": "HS2ST_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7LGA3",
                "type": "external"
            }
        ],
        "mass": 41881.0,
        "length": 356,
        "protein_name": "Heparan sulfate 2-O-sulfotransferase 1",
        "gene_name": "HS2ST1",
        "organism": "Human",
        "refseq_name": "heparan sulfate 2-O-sulfotransferase 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001127964",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001127964",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HS2ST1; HS2ST; KIAA0448",
        "gene_names_refseq": "2-OST; HS2ST1; NFSRA; dJ604K5.2",
        "protein_names_uniprotkb": "Heparan sulfate 2-O-sulfotransferase 1; 2-O-sulfotransferase; 2-OST; 2.8.2.-; 2OST; HS 2-O-sulfotransferase; Heparan sulfate 2-sulfotransferase",
        "protein_names_refseq": "2-O-sulfotransferase; 2OST; HS 2-O-sulfotransferase; heparan sulfate 2-O-sulfotransferase 1 isoform 2; heparan sulfate 2-sulfotransferase",
        "tax_id": 9606,
        "disease": "neurofacioskeletal syndrome with or without renal agenesis (MONDO:MONDO:0030966)",
        "pathway": " (hsa:9653);  (R-HSA-2022928)",
        "pathway_count": 2,
        "publication_count": 86,
        "publication_id_list": "10.1101/2023.09.13.557529;10318803;10639137;10644753;10677367;10716625;11087757;11169766;11237011;11274177;11279150;11390981;12138164;12492399;15082721;15607426;16343444;17227754;20554947;21048031;21700882;23090970;24190977;24714562;25502872;25576301;25594747;25892735;26154972;26811146;26992070;27397612;27543614;27846572;27920218;28132690;28148688;28467828;28510447;28649982;29242379;29314611;29632046;29741879;30315122;30410026;30429286;30471091;30573663;31154438;31844290;32157095;32350084;32387766;32502341;32573871;32938616;33043033;33159882;33298915;33392160;33537174;33592498;33717175;33912179;33936100;33968037;34171305;34185709;34357683;34561969;35051231;35154160;35251023;35561310;35580925;35676258;36581221;37074911;37938771;7601448;9346953;9463333;9535912;9915799;9988767",
        "class_list": "glycogene",
        "function": "Analysis of differences and similarities various residues play in the biological roles of the HS-2OST and CS-2OST enzymes, [RefSeq, PubMed]; Bi-allelic Pathogenic Variants in HS2ST1 Cause a Syndrome Characterized by Developmental Delay and Corpus Callosum, Skeletal, and Renal Abnormalities., [RefSeq, PubMed]; C5-epimerase and 2-O-sulfotransferase in association generate extended domains of consecutive GlcNS-IdoA2S Sequence., [RefSeq, PubMed]; Catalyzes the transfer of a sulfo group from 3'-phospho-5'-adenylyl sulfate (PAPS) to the 2-OH position of iduronic acid (IdoA) or glucuronic acid (GlcA) within the heparan sulfate (HS) chain and participates in HS biosynthesis (By similarity). Required for metanephric development of kidney formation, suggesting that 2-O-sulfation within HS is essential for signaling between ureteric bud and metanephric mesenchyme (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; HS2ST1-dependent signaling pathways determine breast cancer cell viability, matrix interactions, and invasive behavior., [RefSeq, PubMed]; Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. This gene encodes a member of the heparan sulfate biosynthetic enzyme family that transfers sulfate to the 2 position of the iduronic acid residue of heparan sulfate. The disruption of this gene resulted in no kidney formation in knockout embryonic mice, indicating that the absence of this enzyme may interfere with the signaling required for kidney formation. Two alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Aug 2008]., [RefSeq]; Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 374,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 33,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DT22;O75036;Q32NB5;Q8TAC5;Q9H441;Q9NUJ9",
        "ec_number_list": [
            {
                "id": "2.8.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004394 heparan sulfate 2-sulfotransferase activity;GO:0008146 sulfotransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.3,
        "record_id": "Q7LGA3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000000.100.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q08623-1",
        "uniprot_id": [
            {
                "id": "HDHD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q08623",
                "type": "external"
            }
        ],
        "mass": 25249.0,
        "length": 228,
        "protein_name": "Pseudouridine-5'-phosphatase",
        "gene_name": "PUDP",
        "organism": "Human",
        "refseq_name": "pseudouridine-5'-phosphatase isoform a",
        "refseq_ac": [
            {
                "id": "NP_001129037",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129037",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PUDP; DXF68S1E; FAM16AX; GS1; HDHD1A; HDHD1",
        "gene_names_refseq": "DXF68S1E; FAM16AX; GS1; HDHD1A; HDHD1; PUDP",
        "protein_names_uniprotkb": "Pseudouridine-5'-phosphatase; 3.1.3.96; 5'-PsiMPase; Haloacid dehalogenase-like hydrolase domain-containing protein 1A; Haloacid dehalogenase-like hydrolase domain-containing protein 1; Protein GS1; Pseudouridine-5'-monophosphatase",
        "protein_names_refseq": "5'-PsiMPase; family with sequence similarity 16, member A, X-linked; haloacid dehalogenase-like hydrolase domain containing 1A; haloacid dehalogenase-like hydrolase domain-containing protein 1A; haloacid dehalogenase-like hydrolase domain-containing protein 1; pseudouridine-5'-monophosphatase; pseudouridine-5'-phosphatase isoform a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8226);  (R-HSA-73614)",
        "pathway_count": 2,
        "publication_count": 44,
        "publication_id_list": "1063125;11237011;11306702;12199906;12429345;12808445;1284467;12849978;1406603;14609716;14725767;15130468;15689149;15733844;1590793;1597187;19291308;195585;1996353;20068231;2026611;20722631;2539852;2542307;2548513;27600516;27920218;28063628;2844225;29393594;31530632;31844290;32350084;32357974;33298915;3335503;3372530;37895274;7284378;7488099;7923172;8340387;9804782;9989599",
        "class_list": "",
        "function": "Dephosphorylates pseudouridine 5'-phosphate, a potential intermediate in rRNA degradation. Pseudouridine is then excreted intact in urine., [UniProtKB, PubMed]; HDHD1 is a phosphatase specifically involved in dephosphorylation of a modified nucleotide present in RNA., [RefSeq, PubMed]; STS and PUDP Deletion Identified by Targeted Panel Sequencing with CNV Analysis in X-Linked Ichthyosis: A Case Report and Literature Review. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the haloacid dehalogenase-like (HAD) hydrolase superfamily. The encoded protein has no known biological function. This gene has a pseudogene on chromosome 1. Multiple alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7X6;B4DV93;B7Z6Q3;E9PAV8;F5GWZ2;Q53F84;Q96EB8",
        "ec_number_list": [
            {
                "id": "3.1.3.96",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.96",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0016791 phosphatase activity;GO:1990738 pseudouridine 5'-phosphatase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0009117 nucleotide metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q08623-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P26927-1",
        "uniprot_id": [
            {
                "id": "HGFL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P26927",
                "type": "external"
            }
        ],
        "mass": 80320.0,
        "length": 711,
        "protein_name": "Hepatocyte growth factor-like protein",
        "gene_name": "MST1",
        "organism": "Human",
        "refseq_name": "hepatocyte growth factor-like protein isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_066278",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066278",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MST1; D3F15S2; DNF15S2; HGFL",
        "gene_names_refseq": "D3F15S2; DNF15S2; HGFL; MSP; MST1; NF15S2",
        "protein_names_uniprotkb": "Hepatocyte growth factor-like protein; MSP; Macrophage stimulatory protein; Macrophage-stimulating protein",
        "protein_names_refseq": "hepatocyte growth factor-like protein homolog; hepatocyte growth factor-like protein isoform 1 precursor; macrophage stimulating 1 (hepatocyte growth factor-like); macrophage-stimulating protein",
        "tax_id": 9606,
        "disease": "inflammatory bowel disease (Disease Ontology:DOID:0050589)",
        "pathway": " (hsa:4485);  (R-HSA-8852405)",
        "pathway_count": 2,
        "publication_count": 36,
        "publication_id_list": "37268159;10671200;11237011;15632155;15792801;16279944;16335952;1655021;1827141;1885621;19079170;19159218;20228799;20545605;20726546;21875933;22087277;24409221;25193665;29314611;29391424;29557506;29671580;29741879;30459171;30795621;33043033;35051231;35580925;36623453;37074911;37217939;8346233;8393443;9202013;9657372",
        "class_list": "",
        "function": "Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice., [RefSeq, PubMed]; The protein encoded by this gene contains four kringle domains and a serine protease domain, similar to that found in hepatic growth factor. Despite the presence of the serine protease domain, the encoded protein may not have any proteolytic activity. The receptor for this protein is RON tyrosine kinase, which upon activation stimulates ciliary motility of ciliated epithelial lung cells. This protein is secreted and cleaved to form an alpha chain and a beta chain bridged by disulfide bonds. [provided by RefSeq, Jan 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 21,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NLA3;A8MSX3;Q13350;Q14870;Q6GTN4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030971 receptor tyrosine kinase binding;GO:0004252 serine-type endopeptidase activity;GO:0035173 histone kinase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0046425 regulation of receptor signaling pathway via JAK-STAT;GO:0006508 proteolysis;GO:0045721 negative regulation of gluconeogenesis;GO:2000479 regulation of cAMP-dependent protein kinase activity;GO:0007283 spermatogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "P26927-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95256-1",
        "uniprot_id": [
            {
                "id": "I18RA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95256",
                "type": "external"
            }
        ],
        "mass": 68310.0,
        "length": 599,
        "protein_name": "Interleukin-18 receptor accessory protein",
        "gene_name": "IL18RAP",
        "organism": "Human",
        "refseq_name": "interleukin-18 receptor accessory protein isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_003844",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003844",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL18RAP; IL1R7",
        "gene_names_refseq": "ACPL; CD218b; CDw218b; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1R-7; IL-1R7; IL-1RAcPL; IL18RAP; IL18RB",
        "protein_names_uniprotkb": "Interleukin-18 receptor accessory protein; 3.2.2.6; AcPL; Accessory protein-like; CD218 antigen-like family member B; CDw218b; IL-18 receptor accessory protein; IL-18R-beta; IL-18RAcP; IL-18Rbeta; IL-1R accessory protein-like; IL-1R-7; IL-1R7; IL-1RAcPL; Interleukin-1 receptor 7; Interleukin-18 receptor accessory protein-like; Interleukin-18 receptor beta",
        "protein_names_refseq": "CD218 antigen-like family member B; IL-18 receptor accessory protein; IL-18 receptor beta; cluster of differentiation w218b; interleukin-1 receptor 7; interleukin-18 receptor accessory protein isoform 1 precursor; interleukin-18 receptor beta",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8807);  (R-HSA-9012546)",
        "pathway_count": 2,
        "publication_count": 21,
        "publication_id_list": "10023777;10653850;10925275;11046021;11237011;14528293;17897836;25500532;25892735;26992070;28832583;29557506;31092671;32938616;33141586;33823154;35051231;35361972;37698530;9325300;9792649",
        "class_list": "",
        "function": "A novel anti-human IL-1R7 antibody reduces IL-18-mediated inflammatory signaling., [RefSeq, PubMed]; Prognostic and immunological roles of IL18RAP in human cancers., [RefSeq, PubMed]; The protein encoded by this gene is an accessory subunit of the heterodimeric receptor for interleukin 18 (IL18), a proinflammatory cytokine involved in inducing cell-mediated immunity. This protein enhances the IL18-binding activity of the IL18 receptor and plays a role in signaling by IL18. Mutations in this gene are associated with Crohn's disease and inflammatory bowel disease, and susceptibility to celiac disease and leprosy. Alternatively spliced transcript variants of this gene have been described, but their full-length nature is not known. [provided by RefSeq, Feb 2014]., [RefSeq]; Truncated forms of IL-18RAP may be involved in the complex mechanism of IL-18 activity regulation., [RefSeq, PubMed]; Whole-genome sequencing reveals that variants in the Interleukin 18 Receptor Accessory Protein 3'UTR protect against ALS., [RefSeq, PubMed]; Within the IL18 receptor complex, does not mediate IL18-binding, but involved in IL18-dependent signal transduction, leading to NF-kappa-B and JNK activation (PubMed:14528293, PubMed:25500532, PubMed:9792649). May play a role in IL18-mediated IFNG synthesis from T-helper 1 (Th1) cells (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RPJ3;Q2QDE5;Q3KPE7;Q3KPE8;Q53TT4;Q53TU5",
        "ec_number_list": [
            {
                "id": "3.2.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.6",
                "type": "external"
            },
            {
                "id": "2.4.99.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.99.20",
                "type": "external"
            },
            {
                "id": "3.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0015026 coreceptor activity;GO:0061809 NAD+ nucleosidase activity, cyclic ADP-ribose generating;GO:0042008 interleukin-18 receptor activity",
        "go_cellular_component": "GO:0045092 interleukin-18 receptor complex;GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0045063 T-helper 1 cell differentiation;GO:0006954 inflammatory response;GO:0006955 immune response;GO:0050830 defense response to Gram-positive bacterium;GO:0071222 cellular response to lipopolysaccharide",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "O95256-1",
        "record_type": "protein",
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    },
    {
        "uniprot_canonical_ac": "P61296-1",
        "uniprot_id": [
            {
                "id": "HAND2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P61296",
                "type": "external"
            }
        ],
        "mass": 23666.0,
        "length": 217,
        "protein_name": "Heart- and neural crest derivatives-expressed protein 2",
        "gene_name": "HAND2",
        "organism": "Human",
        "refseq_name": "heart- and neural crest derivatives-expressed protein 2",
        "refseq_ac": [
            {
                "id": "NP_068808",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068808",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HAND2; BHLHA26; DHAND",
        "gene_names_refseq": "DHAND2; HAND2; Hed; Thing2; bHLHa26; dHand",
        "protein_names_uniprotkb": "Heart- and neural crest derivatives-expressed protein 2; Class A basic helix-loop-helix protein 26; Deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; bHLHa26; dHAND",
        "protein_names_refseq": "basic helix-loop-helix transcription factor HAND2; class A basic helix-loop-helix protein 26; deciduum, heart, autonomic nervous system and neural crest derivatives-expressed protein 2; heart- and neural crest derivatives-expressed protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9464);  (R-HSA-8878166);  (R-HSA-9733709)",
        "pathway_count": 3,
        "publication_count": 30,
        "publication_id_list": "11237011;11857736;12391164;12434152;12434156;15030764;15095414;16407259;17142326;17171635;18223689;19144722;19348682;19479054;21913213;22065775;22544321;24850862;25187301;26783251;29636455;33054971;36416237;36598365;37073844;38030295;38262560;9182764;9207800;9878849",
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        "function": "Essential for cardiac morphogenesis, particularly for the formation of the right ventricle and of the aortic arch arteries. Required for vascular development and regulation of angiogenesis, possibly through a VEGF signaling pathway. Also plays an important role in limb development, particularly in the establishment of anterior-posterior polarization, acting as an upstream regulator of sonic hedgehog (SHH) induction in the limb bud. Is involved in the development of branchial arches, which give rise to unique structures in the head and neck. Binds DNA on E-box consensus sequence 5'-CANNTG-3' (By similarity)., [UniProtKB]; HAND2 Assists MYCN Enhancer Invasion to Regulate a Noradrenergic Neuroblastoma Phenotype., [RefSeq, PubMed]; HAND2 suppresses favipiravir efficacy in treatment of Borna disease virus infection., [RefSeq, PubMed]; Molecular Genetic Study on HAND2 Gene Promoter in Ventricular Septal Defect., [RefSeq, PubMed]; NONO enhances mRNA processing of super-enhancer-associated GATA2 and HAND2 genes in neuroblastoma., [RefSeq, PubMed]; The protein encoded by this gene belongs to the basic helix-loop-helix family of transcription factors. This gene product is one of two closely related family members, the HAND proteins, which are asymmetrically expressed in the developing ventricular chambers and play an essential role in cardiac morphogenesis. Working in a complementary fashion, they function in the formation of the right ventricle and aortic arch arteries, implicating them as mediators of congenital heart disease. In addition, this transcription factor plays an important role in limb and branchial arch development. [provided by RefSeq, Jul 2008]., [RefSeq]; [Association of ventricular septal defect with rare variations of the HAND2 gene]., [RefSeq, PubMed]",
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        "secondary_ac_list": "B6ECG9;O95300;O95301;P97833;Q494T1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0042803 protein homodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development;GO:0010628 positive regulation of gene expression",
        "synthesized_glycan_count": 0,
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        "record_id": "P61296-1",
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    {
        "uniprot_canonical_ac": "P31268-1",
        "uniprot_id": [
            {
                "id": "HXA7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P31268",
                "type": "external"
            }
        ],
        "mass": 25355.0,
        "length": 230,
        "protein_name": "Homeobox protein Hox-A7",
        "gene_name": "HOXA7",
        "organism": "Human",
        "refseq_name": "homeobox protein Hox-A7",
        "refseq_ac": [
            {
                "id": "NP_008827",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008827",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HOXA7; HOX1A",
        "gene_names_refseq": "ANTP; HOX1.1; HOX1A; HOX1; HOXA7",
        "protein_names_uniprotkb": "Homeobox protein Hox-A7; Homeobox protein Hox 1.1; Homeobox protein Hox-1A",
        "protein_names_refseq": "homeo box A7; homeobox protein HOX-1A; homeobox protein Hox 1.1; homeobox protein Hox-A7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3204)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "10911612;11237011;11435435;25576301;2576652;30720179;30779550;31670914;32305054;33298915;33691108;33981976;34978042;36241641;9804983",
        "class_list": "",
        "function": "CircPAPPA Regulates the Proliferation, Migration, Invasion, Apoptosis, and Cell Cycle of Trophoblast Cells Through the miR-3127-5p/HOXA7 Axis., [RefSeq, PubMed]; Correlation of miR-181a and three HOXA genes as useful biomarkers in acute myeloid leukemia., [RefSeq, PubMed]; In vertebrates, the genes encoding the class of transcription factors called homeobox genes are found in clusters named A, B, C, and D on four separate chromosomes. Expression of these proteins is spatially and temporally regulated during embryonic development. This gene is part of the A cluster on chromosome 7 and encodes a DNA-binding transcription factor which may regulate gene expression, morphogenesis, and differentiation. For example, the encoded protein represses the transcription of differentiation-specific genes during keratinocyte proliferation, but this repression is then overcome by differentiation signals. This gene is highly similar to the antennapedia (Antp) gene of Drosophila. [provided by RefSeq, Jul 2008]., [RefSeq]; MiR-193a-5p suppresses cell proliferation and induces cell apoptosis by regulating HOXA7 in human ovarian cancer., [RefSeq, PubMed]; Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis., [UniProtKB]; Study found the miR-144-3p expression was reduced in neuroblastoma (NB) tissues and cell lines and resulted in the stimulation of cell proliferation, cell cycle progression, and cell migration in vitro. Homeobox protein A7 (HOXA7) was validated as a direct target of miR-144-3p. Results demonstrated the tumor suppressive role of miR-144-3p in NB., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
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        "secondary_ac_list": "A4D191;O43368;O43486;O95655;Q9NSC8;Q9UDM1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0045617 negative regulation of keratinocyte differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
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        "record_id": "P31268-1",
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    {
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                "id": "F180B_HUMAN",
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        ],
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        "protein_name": "Protein FAM180B",
        "gene_name": "FAM180B",
        "organism": "Human",
        "refseq_name": "protein FAM180B isoform 1 precursor",
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            {
                "id": "NP_001157851",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157851",
                "type": "external"
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        ],
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        "gene_names_refseq": "FAM180B",
        "protein_names_uniprotkb": "Protein FAM180B",
        "protein_names_refseq": "hypothetical gene supported by BC065704; protein FAM180B isoform 1 precursor; protein FAM180B",
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    {
        "uniprot_canonical_ac": "Q8WUF8-1",
        "uniprot_id": [
            {
                "id": "ARB2A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WUF8",
                "type": "external"
            }
        ],
        "mass": 47972.0,
        "length": 416,
        "protein_name": "Cotranscriptional regulator ARB2A",
        "gene_name": "ARB2A",
        "organism": "Human",
        "refseq_name": "cotranscriptional regulator ARB2A isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001156889",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001156889",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ARB2A; C5orf21; FAM172A",
        "gene_names_refseq": "ARB2A; C5orf21; FAM172A; Toupee",
        "protein_names_uniprotkb": "Cotranscriptional regulator ARB2A; ARB2 cotranscriptional regulator A; Cotranscriptional regulator FAM172A; Protein FAM172A",
        "protein_names_refseq": "cotranscriptional regulator ARB2A isoform 2; cotranscriptional regulator ARB2A; cotranscriptional regulator FAM172A; family with sequence similarity 172 member A; protein FAM172A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83989)",
        "pathway_count": 1,
        "publication_count": 44,
        "publication_id_list": "11230166;11237011;20112406;20137623;20818486;21092515;23481700;25576301;25645385;26573560;26992070;28218747;28904123;29311329;29393594;29437277;29557506;29632711;30410026;30429286;31844290;31915594;31988090;32157095;32265295;32387766;32502341;32897882;32938616;32983136;33095186;33592498;33968037;34171305;34357683;34405274;34932366;35051231;35580925;36010968;36241641;36284347;37221016;39534244",
        "class_list": "",
        "function": "FAM172 protein expression in human aortic smooth muscle cells was up-regulated by high glucose levels in a concentration-dependent and time-course manner., [RefSeq, PubMed]; FAM172A inhibits EMT in pancreatic cancer via ERK-MAPK signaling. Publication Status: Online-Only, [RefSeq, PubMed]; FAM172A promotes follicular thyroid carcinogenesis and may be a marker of FTC., [RefSeq, PubMed]; FAM172A protein is expressed at high levels in human papillary thyroid carcinoma, which may promote cell proliferation via activation of the p38 MAPK signaling pathway., [RefSeq, PubMed]; FAM172A protein promotes cell proliferation, inhibits cell apoptosis and facilitates S-phase entry in HEK293 cells., [RefSeq, PubMed]; FAM172A recombinant protein could induce proliferation of HepG2 cells, in which the MAPK/ERK and PI3K/Akt signaling pathways might be involved. The role of FAM172A in HepG2 cell proliferation also indicated its possible involvement in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Plays a role in the regulation of alternative splicing, by interacting with AGO2 and CHD7. Seems to be required for stabilizing protein-protein interactions at the chromatin-spliceosome interface. May have hydrolase activity., [UniProtKB, UniProtKB]; The CHARGE syndrome-associated protein FAM172A controls AGO2 nuclear import. Publication Status: Online-Only, [RefSeq, PubMed]; The changes of C5orf21 gene expression are correlated with diabetic macroangiopathy., [RefSeq, PubMed]",
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        "secondary_ac_list": "B2R7C6;B4DJ14;B4DLG5;Q9H0U8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0014032 neural crest cell development;GO:0031048 regulatory ncRNA-mediated heterochromatin formation;GO:0000381 regulation of alternative mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q8WUF8-1",
        "record_type": "protein",
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    },
    {
        "uniprot_canonical_ac": "Q86V87-1",
        "uniprot_id": [
            {
                "id": "FHI2B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86V87",
                "type": "external"
            }
        ],
        "mass": 82340.0,
        "length": 743,
        "protein_name": "FHF complex subunit HOOK-interacting protein 2B",
        "gene_name": "FHIP2B",
        "organism": "Human",
        "refseq_name": "FHF complex subunit HOOK-interacting protein 2B isoform 1",
        "refseq_ac": [
            {
                "id": "NP_073586",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073586",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FHIP2B; FAM160B2; FP13191; RAI16",
        "gene_names_refseq": "FAI16; FAM160B2; FHIP2B; RAI16; RAM160B2",
        "protein_names_uniprotkb": "FHF complex subunit HOOK-interacting protein 2B; FHIP2B; Retinoic acid-induced protein 16",
        "protein_names_refseq": "FHF complex subunit HOOK-interacting protein 2B isoform 1; family with sequence similarity 160 member B2; protein FAM160B2; retinoic acid induced 16; retinoic acid-induced protein 16",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64760)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "11237011;15498874;22971576;23481700;24714562;24715725;25418920;25576301;25892735;25900241;26154972;26992070;27862975;28228285;28832583;29242379;29557506;29769354;30315122;30429286;31353455;31844290;31862898;32014455;32157095;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33298915;33392160;33592498;33717175;33936100;33968037;33981976;34087483;34171305;34211107;34509645;34932366;35051231;35580925;36010968;36241641;36581221",
        "class_list": "",
        "function": "Able to activate MAPK/ERK and TGFB signaling pathways (PubMed:22971576). May regulate the activity of genes involved in intestinal barrier function and immunoprotective inflammation (By similarity). May play a role in cell proliferation (PubMed:22971576)., [UniProtKB, UniProtKB, PubMed]; FAM160B1 deficit associated with microcephaly, severe intellectual disability, ataxia, behavioral abnormalities and speech problems., [RefSeq, PubMed]; Identification of retinoid acid induced 16 as a novel androgen receptor target in prostate cancer cells., [RefSeq, PubMed]; RAI16 interacted with the type II regulatory subunit of protein kinase A(PKA-RIIalpha), acting as a novel protein kinase A anchoring protein (AKAP). In addition, RAI16 also interacted with heat shock protein 70 (HSP70) and 14-3-3theta;., [RefSeq, PubMed]; Retinoic acid induced 16 enhances tumorigenesis and serves as a novel tumor marker for hepatocellular carcinoma., [RefSeq, PubMed]; Retinoid acid induced 16 deficiency aggravates colitis and colitis-associated tumorigenesis in mice. Publication Status: Online-Only, [RefSeq, PubMed]",
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        "secondary_ac_list": "B2RDQ5;B3KNX1;Q2M211;Q71JB5;Q7L3J6;Q969T0;Q9H6W4",
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        "hit_score": 5.0,
        "record_id": "Q86V87-1",
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    },
    {
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            {
                "id": "GAK1A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UFP1",
                "type": "external"
            }
        ],
        "mass": 63637.0,
        "length": 575,
        "protein_name": "Golgi-associated kinase 1A",
        "gene_name": "GASK1A",
        "organism": "Human",
        "refseq_name": "Golgi-associated kinase 1A precursor",
        "refseq_ac": [
            {
                "id": "NP_001123380",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123380",
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            }
        ],
        "gene_names_uniprotkb": "GASK1A; C3orf41; FAM198A",
        "gene_names_refseq": "C3orf41; FAM198A; GASK1A",
        "protein_names_uniprotkb": "Golgi-associated kinase 1A; Protein FAM198A",
        "protein_names_refseq": "Golgi-associated kinase 1A precursor; family with sequence similarity 198 member A; protein FAM198A",
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        "disease": "",
        "pathway": " (hsa:729085)",
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        "publication_count": 15,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;11237011;22171320;23584533;30188967;30459171;30524438;31596135;32488085;32983136;33981976;35051231;36215666;36284347",
        "class_list": "",
        "function": "Results find that in the male newborns whose mother had preconception folic acid (FA) supplementation, five sites within FAM198A had a reduced methylation than appropriate for gestational age controls., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        ],
        "mass": 42387.0,
        "length": 369,
        "protein_name": "Protein FAM187B",
        "gene_name": "FAM187B",
        "organism": "Human",
        "refseq_name": "protein FAM187B precursor",
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            {
                "id": "NP_689694",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689694",
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            }
        ],
        "gene_names_uniprotkb": "FAM187B; TMEM162",
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        "protein_names_refseq": "protein FAM187B precursor; protein FAM187B; transmembrane protein 162",
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        "secondary_ac_list": "Q8N7G6",
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        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010000.101.00000",
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    },
    {
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            {
                "id": "F209A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5JX71",
                "type": "external"
            }
        ],
        "mass": 19603.0,
        "length": 171,
        "protein_name": "Protein FAM209A",
        "gene_name": "FAM209A",
        "organism": "Human",
        "refseq_name": "protein FAM209A precursor",
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            {
                "id": "NP_001012989",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012989",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM209A; C20orf106",
        "gene_names_refseq": "C20orf106; FAM209A; dJ1153D9.3",
        "protein_names_uniprotkb": "Protein FAM209A",
        "protein_names_refseq": "protein FAM209A precursor; protein FAM209A; uncharacterized protein C20orf106",
        "tax_id": 9606,
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        "function": "May play a role in sperm acrosome biogenesis., [UniProtKB, UniProtKB]",
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        "secondary_ac_list": "Q05C43",
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        "go_cellular_component": "GO:0005634 nucleus;GO:0070062 extracellular exosome;GO:0005637 nuclear inner membrane",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation",
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    {
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                "url": "https://www.uniprot.org/uniprot/Q5VUB5",
                "type": "external"
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        ],
        "mass": 97854.0,
        "length": 890,
        "protein_name": "Protein FAM171A1",
        "gene_name": "FAM171A1",
        "organism": "Human",
        "refseq_name": "protein FAM171A1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001010924",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010924",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM171A1; APCN; C10orf38",
        "gene_names_refseq": "APCN; C10orf38; FAM171A1",
        "protein_names_uniprotkb": "Protein FAM171A1; APCN; Astroprincin",
        "protein_names_refseq": "astroprincin; protein FAM171A1 precursor; protein FAM171A1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:221061)",
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        "publication_id_list": "11237011;18077418;18318008;18578522;19159218;19664994;22299025;23186163;24275569;28657654;29242379;29557506;29789417;30312582;31020640;32350084;32387766;33592498;33968037;34171305;35251023;35318648;35561310;37938771",
        "class_list": "",
        "function": "APCN regulates the dynamics of the actin cytoskeletal and, thereby, the cell shape and invasive growth potential of tumor cells., [RefSeq, PubMed]; Involved in the regulation of the cytoskeletal dynamics, plays a role in actin stress fiber formation., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
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        "secondary_ac_list": "D3DRT9;Q32M49;Q8N4I0",
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0008360 regulation of cell shape;GO:0043149 stress fiber assembly",
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    {
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        ],
        "mass": 16478.0,
        "length": 155,
        "protein_name": "Protein FAM201A",
        "gene_name": "FAM201A",
        "organism": "Human",
        "refseq_name": "",
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        "gene_names_uniprotkb": "FAM201A; C9orf122",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Protein FAM201A",
        "protein_names_refseq": "",
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        "hit_score": 0.4,
        "record_id": "Q5SY85-1",
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        "filter_code": "0000000.0000100.100000.000000000001000000.0100000000000.000.00000",
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    },
    {
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        "uniprot_id": [
            {
                "id": "FA83B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5T0W9",
                "type": "external"
            }
        ],
        "mass": 114799.0,
        "length": 1011,
        "protein_name": "Protein FAM83B",
        "gene_name": "FAM83B",
        "organism": "Human",
        "refseq_name": "protein FAM83B",
        "refseq_ac": [
            {
                "id": "NP_001010872",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010872",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM83B; C6orf143",
        "gene_names_refseq": "C6orf143; FAM83B; SACK1B",
        "protein_names_uniprotkb": "Protein FAM83B",
        "protein_names_refseq": "family with sequence similarity 83 member B; protein FAM83B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:222584);  (R-HSA-177929);  (R-HSA-9696264);  (R-HSA-9696270);  (R-HSA-9696273)",
        "pathway_count": 5,
        "publication_count": 51,
        "publication_id_list": "10.1101/2023.09.13.557529;10664463;11784792;11940653;12244061;12842009;14732713;15738000;16481321;1688559;18669648;18996843;19007248;19103606;19136556;19691289;20068231;2022652;20811643;22886302;23186163;23676467;23912460;24690281;2543678;25576301;25888806;26969432;29242379;29393594;29557506;29789297;30379171;30779550;31075398;31154438;31871319;32488085;33649801;33981976;34185709;35051231;35318648;35580925;35597845;36690987;38478170;8639530;8649376;8845374;9531558",
        "class_list": "",
        "function": "Ablation of FAM83B decreased p110alpha and AKT membrane localization, suppressed AKT phosphorylation, and diminished proliferation, AIG, and tumorigenicity in vivo., [RefSeq, PubMed]; FAM83B expression was significantly elevated in cancer and was associated with specific cancer subtypes, increased tumor grade, and decreased overall survival., [RefSeq, PubMed]; FAM83B is involved in thyroid cancer cell differentiation and migration. Publication Status: Online-Only, [RefSeq, PubMed]; FAM83B promotes the invasion of primary lung adenocarcinoma via PI3K/AKT/NF-kappaB pathway. Publication Status: Online-Only, [RefSeq, PubMed]; FAM83B regulates mitochondrial metabolism and anti-apoptotic activity in pulmonary adenocarcinoma., [RefSeq, PubMed]; MicroRNA199a/b5p inhibits endometrial cancer cell metastasis and invasion by targeting FAM83B in the epithelialtomesenchymal transition signaling pathway., [RefSeq, PubMed]; Probable proto-oncogene that functions in the epidermal growth factor receptor/EGFR signaling pathway. Activates both the EGFR itself and downstream RAS/MAPK and PI3K/AKT/TOR signaling cascades., [UniProtKB, PubMed, PubMed, PubMed]; Suppression of PLD1 activity prevents FAM83B-mediated transformation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "secondary_ac_list": "Q2M1P3;Q96DQ2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0005154 epidermal growth factor receptor binding;GO:0036312 phosphatidylinositol 3-kinase regulatory subunit binding;GO:0036313 phosphatidylinositol 3-kinase catalytic subunit binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0008283 cell population proliferation;GO:0045742 positive regulation of epidermal growth factor receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q5T0W9-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
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    {
        "uniprot_canonical_ac": "Q5U5X8-1",
        "uniprot_id": [
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        ],
        "mass": 46792.0,
        "length": 452,
        "protein_name": "Protein FAM222A",
        "gene_name": "FAM222A",
        "organism": "Human",
        "refseq_name": "protein FAM222A",
        "refseq_ac": [
            {
                "id": "NP_116218",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116218",
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            }
        ],
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        "gene_names_refseq": "C12orf34; FAM222A",
        "protein_names_uniprotkb": "Protein FAM222A",
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        "pathway": " (hsa:84915)",
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        "publication_count": 9,
        "publication_id_list": "29557506;29632711;31844290;31964863;32157095;33298915;35254053;35580925;37942611",
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        "function": "FAM222A, Part of the BET-Regulated Basal Endothelial Transcriptome, Is a Novel Determinant of Endothelial Biology and Angiogenesis-Brief Report., [RefSeq, PubMed]; Study reports FAM222A as a putative brain atrophy susceptibility gene. The protein encoded by FAM222A is predominantly expressed in the CNS and is increased in brains of patients with Alzheimer's disease (AD) and in an AD mouse model. It accumulates within amyloid deposits, physically interacts with amyloid-beta (Abeta) via its N-terminal Abeta binding domain and facilitates Abeta aggregation. Erratum:[Nat Commun. 2022 Jul 11;13(1):4006. doi: 10.1038/s41467-022-31711-8. PMID: 35817794] Publication Status: Online-Only, [RefSeq, PubMed]",
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        ],
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        "length": 115,
        "protein_name": "Protein VCF2",
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        "refseq_name": "protein VCF2 isoform 2",
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                "id": "NP_001160171",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001160171",
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        "function": "The FAM104 proteins VCF1/2 promote the nuclear localization of p97/VCP. Publication Status: Online-Only, [RefSeq, PubMed]",
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        "protein_name": "Protein FAM171B",
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_803237",
                "type": "external"
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        "protein_names_refseq": "protein FAM171B precursor; protein FAM171B",
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        "publication_id_list": "10.1101/2023.09.13.557529;17081983;18578522;22424782;22544926;24715725;25576301;25645385;26154972;26992070;27846572;29557506;30429286;30779550;30861353;31844290;31848261;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33392160;33537174;33912179;33968037;33981976;34052262;34357683;35051231;35561310;36010968;36215666;36241641;36284347;37915048;37938771",
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        "function": "FAM171B expression is up-regulated in oxaliplatin-resistant colorectal cancer cell line. Transfection of miR-483-3p mimics markedly decreases the levels of FAM171B and restores oxaliplatin responsiveness, and this alteration enhances cell apoptosis and weakens cell migration. Knockdown of FAM171B in oxaliplatin-resistant colorectal cancer cell line sensitizes its reaction of the treatment with oxaliplatin., [RefSeq, PubMed]; FAM171B is a novel polyglutamine protein widely expressed in the mammalian brain., [RefSeq, PubMed]; FAM171B stabilizes vimentin and enhances CCL2-mediated TAM infiltration to promote bladder cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]",
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        ],
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997201",
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        "protein_names_refseq": "ETS translocation variant 3-like protein; ETS variant 3 like; ets variant 3-like; ets variant gene 3-like",
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        "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
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        ],
        "mass": 19954.0,
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        "protein_name": "Membrane protein FAM174A",
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940909",
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        "protein_names_refseq": "HCV NS5A-transactivated protein 6; hepatitis C virus NS5A-transactivated protein 6; hepatitis C virus nonstructural protein 5A trans-activated protein 6; membrane protein FAM174A precursor; membrane protein FAM174A; transmembrane protein 157",
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        "function": "NS5ATP6 regulates the intracellular triglyceride level via FGF21, and independently of SIRT1 and SREBP1., [RefSeq, PubMed]",
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    {
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        ],
        "mass": 64756.0,
        "length": 605,
        "protein_name": "Golgi-associated RAB2 interactor protein 3",
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        ],
        "gene_names_uniprotkb": "GARIN3; FAM71B; HSD-51; HSD51",
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        "protein_names_refseq": "Golgi associated RAB2 interactor protein 3; Golgi-associated RAB2 interactor protein 3; family with sequence similarity 71 member B; golgi associated RAB2B interactor family member 3; protein FAM71B; testicular tissue protein Li 68",
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        "secondary_ac_list": "Q1EDD9;Q8TC64;Q96LY8",
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        ],
        "mass": 40728.0,
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        "protein_name": "Protein FAM110B",
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671722",
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            }
        ],
        "gene_names_uniprotkb": "FAM110B; C8orf72",
        "gene_names_refseq": "C8orf72; FAM110B",
        "protein_names_uniprotkb": "Protein FAM110B",
        "protein_names_refseq": "protein FAM110B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:90362)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "16959974;17499476;19240061;19651622;19664994;20068231;21406692;21919029;23186163;30429286;30779550;31154438;31844290;31848261;32161166;35051231;35580925",
        "class_list": "",
        "function": "FAM110B was able to regulate androgen receptor signaling in prostate cancer cells and FAM110B itself was regulated by androgens. FAM110B siRNA inhibited the growth of prostate cancer cells in vitro., [RefSeq, PubMed]; Localizes to centrosomes and accumulates at the microtubule organization center in interphase and at spindle poles in mitosis; ectopic expression impairs cell cycle progression in the G1 phase., [RefSeq, PubMed]; May be involved in tumor progression., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5BM08;Q9Y4K2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q8TC76-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WW52-1",
        "uniprot_id": [
            {
                "id": "F151A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WW52",
                "type": "external"
            }
        ],
        "mass": 64028.0,
        "length": 585,
        "protein_name": "Protein FAM151A",
        "gene_name": "FAM151A",
        "organism": "Human",
        "refseq_name": "protein FAM151A",
        "refseq_ac": [
            {
                "id": "NP_788954",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_788954",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM151A; C1orf179; PRO9836",
        "gene_names_refseq": "C1orf179; FAM151A",
        "protein_names_uniprotkb": "Protein FAM151A",
        "protein_names_refseq": "hyporthetical protein MGC27169; protein FAM151A",
        "tax_id": 9606,
        "disease": "colorectal adenocarcinoma (Disease Ontology:DOID:0050861)",
        "pathway": " (hsa:338094)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "10.1101/2023.09.13.557529;12975309;19913121;20628086;31844290;31848261;32350084;33392160;35051231;35251023;37074911;37340703",
        "class_list": "",
        "function": "Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 55,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VUG5;Q6DKH5;Q6UWV0;Q8NAX9;Q96KY5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q8WW52-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92935-1",
        "uniprot_id": [
            {
                "id": "EXTL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92935",
                "type": "external"
            }
        ],
        "mass": 74697.0,
        "length": 676,
        "protein_name": "Exostosin-like 1",
        "gene_name": "EXTL1",
        "organism": "Human",
        "refseq_name": "exostosin-like 1",
        "refseq_ac": [
            {
                "id": "NP_004446",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004446",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EXTL1; EXTL",
        "gene_names_refseq": "EXTL1; EXTL",
        "protein_names_uniprotkb": "Exostosin-like 1; 2.4.1.224; Exostosin-L; Glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase; Multiple exostosis-like protein",
        "protein_names_refseq": "alpha-N-acetylglucosaminyltransferase II; exostoses (multiple)-like 1; exostosin-L; exostosin-like 1; glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N- acetylglucosaminyltransferase; glucuronyl-N-acetylglucosaminylproteoglycan alpha-1,4-N- acetylglucosaminyltransferase; multiple exostosis-like protein",
        "tax_id": 9606,
        "disease": "hereditary multiple exostoses (Disease Ontology:DOID:206); germ cell cancer (Disease Ontology:DOID:2994)",
        "pathway": " (hsa:2134);  (R-HSA-381038)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "10480354;10575224;10601334;10827079;11390981;12204115;15110891;15466936;16461360;16539657;18664523;21282569;25645385;27600516;29242379;29557506;29769354;31844290;32157095;32488085;32938616;33141586;35051231;7590364;8666242;9037597;9450183;9473480",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Glycosyltransferase required for the biosynthesis of heparan-sulfate (HS) (PubMed:11390981). Transfers N-acetyl-alpha-D-glucosamine to the nascent HS chain (GlcNAcT-II activity) (PubMed:11390981). Appears to lack GlcNAcT I and GlcAT-II activities (PubMed:11390981)., [UniProtKB, PubMed]; This gene is a member of the multiple exostoses (EXT) family of glycosyltransferases, which function in the chain polymerization of heparan sulfate and heparin. The encoded protein harbors alpha 1,4- N-acetylglucosaminyltransferase activity, and is involved in chain elongation of heparan sulfate and possibly heparin. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 819,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6GSC1",
        "ec_number_list": [
            {
                "id": "2.4.1.224",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.224",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008375 acetylglucosaminyltransferase activity;GO:0015020 glucuronosyltransferase activity;GO:0050508 glucuronosyl-N-acetylglucosaminyl-proteoglycan 4-alpha-N-acetylglucosaminyltransferase activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0001501 skeletal system development;GO:0015012 heparan sulfate proteoglycan biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q92935-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96GL9-1",
        "uniprot_id": [
            {
                "id": "F163A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96GL9",
                "type": "external"
            }
        ],
        "mass": 17641.0,
        "length": 167,
        "protein_name": "Protein FAM163A",
        "gene_name": "FAM163A",
        "organism": "Human",
        "refseq_name": "protein FAM163A",
        "refseq_ac": [
            {
                "id": "NP_001316641",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316641",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM163A; C1orf76; NDSP",
        "gene_names_refseq": "C1orf76; FAM163A; NDSP",
        "protein_names_uniprotkb": "Protein FAM163A; Cebelin; Neuroblastoma-derived secretory protein",
        "protein_names_refseq": "cebelin; neuroblastoma derived secretory protein; protein FAM163A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:148753)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "17208556;19671756;37524447",
        "class_list": "",
        "function": "NDSP is specifically overexpressed in neuroblastoma and actively secreted from tumor cells. Furthermore, NDSP serves as a growth factor for neuroblastoma tumor cells through activation of the ERK-mediated proliferation pathway. Erratum:[Mol Cancer Ther. 2009 Sep;8(9):2771. Shang, Xiaoyi [corrected to Shang, Xiaoying]], [RefSeq, PubMed]; Novel loci for ocular axial length identified through extreme-phenotype genome-wide association study in Chinese populations. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8R7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q96GL9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96KN4-1",
        "uniprot_id": [
            {
                "id": "LRAT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96KN4",
                "type": "external"
            }
        ],
        "mass": 32491.0,
        "length": 292,
        "protein_name": "Protein LRATD1",
        "gene_name": "LRATD1",
        "organism": "Human",
        "refseq_name": "protein LRATD1",
        "refseq_ac": [
            {
                "id": "NP_660158",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_660158",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRATD1; FAM84A; NSE1",
        "gene_names_refseq": "FAM84A; LRATD1; NSE1; PP11517",
        "protein_names_uniprotkb": "Protein LRATD1; LRAT domain-containing 1; NSE1; Neurologic sensory protein 1; Protein FAM84A",
        "protein_names_refseq": "family with sequence similarity 84 member A; neurologic sensory protein 1; neurological/sensory 1; protein FAM84A; protein LRATD1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:151354)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "16820875;33751775",
        "class_list": "",
        "function": "May play a role in cell morphology and motility., [UniProtKB, PubMed]; The direct miR-874-3p-target FAM84A promotes tumor development in papillary thyroid cancer., [RefSeq, PubMed]; Up-regulation of FAM84A may play a critical role in progression of colon cancer, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NP76;Q86UZ2;Q8NAH7;Q8TAM5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0000902 cell morphogenesis;GO:0048870 cell motility",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q96KN4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H4H8-1",
        "uniprot_id": [
            {
                "id": "FA83D_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H4H8",
                "type": "external"
            }
        ],
        "mass": 64424.0,
        "length": 585,
        "protein_name": "Protein FAM83D",
        "gene_name": "FAM83D",
        "organism": "Human",
        "refseq_name": "protein FAM83D",
        "refseq_ac": [
            {
                "id": "NP_112181",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112181",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM83D; C20orf129",
        "gene_names_refseq": "C20orf129; CHICA; FAM83D; SACK1D; dJ616B8.3",
        "protein_names_uniprotkb": "Protein FAM83D; Spindle protein CHICA",
        "protein_names_refseq": "family with sequence similarity 83 member D; protein FAM83D; spindle protein CHICA",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81610);  (R-HSA-177929)",
        "pathway_count": 2,
        "publication_count": 88,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15561729;1688559;18220336;18445686;18485706;18691976;20068231;20112406;2022652;22965910;23186163;23481700;23912460;24344117;24397554;24715725;24736947;25418920;2543678;25576301;25646692;26154972;26375851;26811146;26992070;27600516;27846572;27920218;28063628;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29789417;30315122;30524438;31075398;31217245;31338967;31530632;31844290;31848261;31937595;32157095;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33214551;33298915;33537174;33592498;33691108;33912179;33936100;33968037;33981976;34171305;34211107;34405274;34509645;34932366;35489022;35580925;36010968;36215666;36241641;36284347;36710419;37217939;38043628;39260674;39894887;8639530;8845374",
        "class_list": "",
        "function": "FAM83D promotes the progression of 4NQO-induced esophageal carcinoma via inhibiting FBWX7., [RefSeq, PubMed]; Interaction partner of the chromokinesin Kid that is required for the generation of polar ejection forces and chromosome congression, [RefSeq, PubMed]; METTL3 regulates FAM83D m[6]A modification to accelerate tumorigenesis of triple-negative breast cancer via the Wnt/beta-catenin pathway., [RefSeq, PubMed]; MiRNA-142-3p functions as a potential tumor suppressor directly targeting FAM83D in the development of ovarian cancer., [RefSeq, PubMed]; Systematic analysis of the oncogenic role of FAM83D across cancers based on data mining., [RefSeq, PubMed]; Through the degradation of FBXW7, may act indirectly on the expression and downstream signaling of MTOR, JUN and MYC (PubMed:24344117). May play also a role in cell proliferation through activation of the ERK1/ERK2 signaling cascade (PubMed:25646692). May also be important for proper chromosome congression and alignment during mitosis through its interaction with KIF22 (PubMed:18485706)., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E1I7;Q5THR2;Q68EN1;Q6P457;Q7Z6H0;Q96DF5;Q96N89;Q9BVM8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0019894 kinesin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol;GO:0015630 microtubule cytoskeleton;GO:0097431 mitotic spindle pole",
        "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0007165 signal transduction;GO:0008283 cell population proliferation;GO:0016477 cell migration;GO:0051301 cell division",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "Q9H4H8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UBU6-1",
        "uniprot_id": [
            {
                "id": "FA8A1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UBU6",
                "type": "external"
            }
        ],
        "mass": 44123.0,
        "length": 413,
        "protein_name": "Protein FAM8A1",
        "gene_name": "FAM8A1",
        "organism": "Human",
        "refseq_name": "protein FAM8A1",
        "refseq_ac": [
            {
                "id": "NP_057339",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057339",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM8A1; AHCP",
        "gene_names_refseq": "AHCP; FAM8A1",
        "protein_names_uniprotkb": "Protein FAM8A1; Autosomal highly conserved protein",
        "protein_names_refseq": "Autosomal Highly Conserved Protein; protein FAM8A1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51439)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;11707071;15144186;18669648;18691976;23186163;26811146;26992070;28218747;28827405;29242379;29393594;29557506;30429286;31154438;31844290;31848261;32157095;32161166;32350084;32488085;32502341;32938616;35051231;35251023;37217939",
        "class_list": "",
        "function": "Plays a role in the assembly of the HRD1 complex, a complex involved in the ubiquitin-proteasome-dependent process of ER-associated degradation (ERAD)., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "reported_phosphosites": 1,
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        "reported_glycation": 0,
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        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R725",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000836 Hrd1p ubiquitin ligase complex",
        "go_biological_process": "GO:0036503 ERAD pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q9UBU6-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P04908-1",
        "uniprot_id": [
            {
                "id": "H2A1B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P04908",
                "type": "external"
            }
        ],
        "mass": 14135.0,
        "length": 130,
        "protein_name": "Histone H2A type 1-B/E",
        "gene_name": "H2AC4; H2AC8",
        "organism": "Human",
        "refseq_name": "histone H2A type 1-B/E",
        "refseq_ac": [
            {
                "id": "NP_003504",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003504",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2AC4; H2AC8; H2AFA; H2AFM; HIST1H2AB; HIST1H2AE",
        "gene_names_refseq": "H2A/m; H2AC4; H2AFM; HIST1H2AB",
        "protein_names_uniprotkb": "Histone H2A type 1-B/E; Histone H2A.2; Histone H2A/a; Histone H2A/m",
        "protein_names_refseq": "H2A histone family, member M; histone 1, H2ab; histone H2A type 1-B/E; histone H2A/m; histone cluster 1 H2A family member b; histone cluster 1, H2ab",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3012);  (hsa:8335);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-3214858);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-5689901);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 57,
        "publication_count": 1102,
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        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]., [RefSeq]; Inhibition of HIST1H2AB suppresses the proliferation of lung adenocarcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P28001;Q76P63",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0008285 negative regulation of cell population proliferation;GO:0006325 chromatin organization;GO:0031507 heterochromatin formation;GO:0061644 protein localization to CENP-A containing chromatin",
        "synthesized_glycan_count": 0,
        "hit_score": 110.8,
        "record_id": "P04908-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P06899-1",
        "uniprot_id": [
            {
                "id": "H2B1J_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P06899",
                "type": "external"
            }
        ],
        "mass": 13904.0,
        "length": 126,
        "protein_name": "Histone H2B type 1-J",
        "gene_name": "H2BC11",
        "organism": "Human",
        "refseq_name": "histone H2B type 1-J",
        "refseq_ac": [
            {
                "id": "NP_066402",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066402",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2BC11; H2BFR; HIST1H2BJ",
        "gene_names_refseq": "H2B/r; H2BC11; H2BFR; H2BJ; HIST1H2BJ",
        "protein_names_uniprotkb": "Histone H2B type 1-J; H2B/r; Histone H2B.1; Histone H2B.r",
        "protein_names_refseq": "H2B histone family, member R; histone 1, H2bj; histone H2B type 1-J; histone H2B.1; histone H2B.r; histone cluster 1 H2B family member j; histone cluster 1, H2bj",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8970);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5689880);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-69473);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8866654);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9821993);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 59,
        "publication_count": 1271,
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        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid., [UniProtKB]; Histone H2A and H2B antimicrobial peptides exhibit antibacterial activity and endotoxin-neutralizing activity in the placenta., [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the histone microcluster on chromosome 6p21.33. [provided by RefSeq, Aug 2015]., [RefSeq]",
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        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4J4;O60816",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0001530 lipopolysaccharide binding;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 127.4,
        "record_id": "P06899-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P16402-1",
        "uniprot_id": [
            {
                "id": "H13_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P16402",
                "type": "external"
            }
        ],
        "mass": 22350.0,
        "length": 221,
        "protein_name": "Histone H1.3",
        "gene_name": "H1-3",
        "organism": "Human",
        "refseq_name": "histone H1.3",
        "refseq_ac": [
            {
                "id": "NP_005311",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005311",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H1-3; H1F3; HIST1H1D",
        "gene_names_refseq": "H1-3; H1.3; H1D; H1F3; H1s-2; HIST1H1D",
        "protein_names_uniprotkb": "Histone H1.3; Histone H1c; Histone H1s-2",
        "protein_names_refseq": "H1 histone family, member 3; histone 1, H1d; histone H1.3; histone H1c; histone H1s-2; histone cluster 1 H1 family member d; histone cluster 1, H1d",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3007);  (R-HSA-140342);  (R-HSA-2559584)",
        "pathway_count": 3,
        "publication_count": 113,
        "publication_id_list": "10318789;10713148;10997781;11746507;11782012;12408966;12748178;15149602;15569692;15595731;15621527;15655109;15910001;15911621;16901784;17043054;17081983;17145369;17158953;17242198;17242207;17287340;17938174;18239742;18283539;18452278;18669648;19029251;1916825;19413330;19415658;20058876;20166139;20305658;21406692;21807893;22121020;22223895;22424782;23186163;23481700;23964094;24714562;24715725;25576301;25645385;25810538;2613692;26154972;27105115;27452731;27846572;28228285;28832583;29242379;29493099;29508533;29557506;29786170;29789417;30154464;30315122;30429286;30444036;31092671;31154438;31217245;31222486;31611695;31844290;31848261;31998317;32157095;32161166;32350084;32387766;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33592498;33691108;33936100;33968037;34019948;34171305;34211107;34433824;34509645;34545082;34561969;34932366;34961760;35051231;35083852;35154160;35251023;35318648;35580925;36241641;36284347;37217939;37922872;37938771;38665916;40240600;40516528;8003976;9108473",
        "class_list": "",
        "function": "Histone H1 protein binds to linker DNA between nucleosomes forming the macromolecular structure known as the chromatin fiber (PubMed:37922872). Histones H1 are necessary for the condensation of nucleosome chains into higher-order structured fibers and promote formation of the H3K27me3 mark by the PRC2/EED-EZH2 complex (PubMed:40516528). Together with histone H1-3, histone H1-3 acts as a regulator of splicing, most specifically exon skipping and intron retention events: histone H1-3 has a high affinity for introns and regulates splicing by affecting RNA polymerase II (RNAPII) elongation (PubMed:37922872). Also acts as a regulator of individual gene transcription through chromatin remodeling, nucleosome spacing and DNA methylation (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Histones are basic nuclear proteins responsible for nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H1 family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R751;Q2M2I2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding;GO:0031490 chromatin DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin;GO:0000791 euchromatin;GO:0000792 heterochromatin;GO:0000786 nucleosome",
        "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0045910 negative regulation of DNA recombination;GO:0048024 regulation of mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "P16402-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P20671-1",
        "uniprot_id": [
            {
                "id": "H2A1D_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P20671",
                "type": "external"
            }
        ],
        "mass": 14107.0,
        "length": 130,
        "protein_name": "Histone H2A type 1-D",
        "gene_name": "H2AC7",
        "organism": "Human",
        "refseq_name": "histone H2A type 1-D",
        "refseq_ac": [
            {
                "id": "NP_066409",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066409",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2AC7; H2AFG; HIST1H2AD",
        "gene_names_refseq": "H2A.3; H2A/g; H2AC7; H2AFG; HIST1H2AD",
        "protein_names_uniprotkb": "Histone H2A type 1-D; Histone H2A.3; Histone H2A/g",
        "protein_names_refseq": "H2A histone family, member G; histone 1, H2ad; histone H2A type 1-D; histone H2A.3; histone H2A/g; histone H2AD; histone cluster 1 H2A family member d; histone cluster 1, H2ad",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3013);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-3214858);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-5689901);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
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        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. This structure consists of approximately 146 bp of DNA wrapped around a nucleosome, an octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails; instead, they contain a palindromic termination element. This gene is found in the large histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0PK91;P57754;Q6FGY6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0031507 heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 107.6,
        "record_id": "P20671-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P57053-1",
        "uniprot_id": [
            {
                "id": "H2BFS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P57053",
                "type": "external"
            }
        ],
        "mass": 13944.0,
        "length": 126,
        "protein_name": "Histone H2B type F-S",
        "gene_name": "H2BC12L",
        "organism": "Human",
        "refseq_name": "histone H2B type F-S",
        "refseq_ac": [
            {
                "id": "NP_059141",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_059141",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2BC12L; H2BFS; H2BS1",
        "gene_names_refseq": "H2B/s; H2BC12L; H2BFS; H2BS1",
        "protein_names_uniprotkb": "Histone H2B type F-S; H2B-clustered histone 12 like; H2B.S histone 1; H2B/s; Histone H2B.s",
        "protein_names_refseq": "H2B histone family member S; H2B.S histone 1; histone H2B type F-S; histone H2B.s; histone protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:102724334);  (hsa:54145);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-69473);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9821993);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 53,
        "publication_count": 1091,
        "publication_id_list": 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        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Has broad antibacterial activity. May contribute to the formation of the functional antimicrobial barrier of the colonic epithelium, and to the bactericidal activity of amniotic fluid., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
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        "biomarker_type": "",
        "glycan_count": 1,
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        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVF9;Q5R2W0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0050830 defense response to Gram-positive bacterium;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0021762 substantia nigra development;GO:0006325 chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 109.4,
        "record_id": "P57053-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14469-1",
        "uniprot_id": [
            {
                "id": "HES1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14469",
                "type": "external"
            }
        ],
        "mass": 29541.0,
        "length": 280,
        "protein_name": "Transcription factor HES-1",
        "gene_name": "HES1",
        "organism": "Human",
        "refseq_name": "transcription factor HES-1",
        "refseq_ac": [
            {
                "id": "NP_005515",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005515",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HES1; BHLHB39; HL; HRY",
        "gene_names_refseq": "HES-1; HES1; HHL; HRY; bHLHb39",
        "protein_names_uniprotkb": "Transcription factor HES-1; Class B basic helix-loop-helix protein 39; Hairy and enhancer of split 1; Hairy homolog; Hairy-like protein; bHLHb39; hHL",
        "protein_names_refseq": "class B basic helix-loop-helix protein 39; hairy homolog; hairy-like protein; transcription factor HES-1",
        "tax_id": 9606,
        "disease": "brain cancer (Disease Ontology:DOID:1319); epilepsy (Disease Ontology:DOID:1826); hemangiopericytoma (Disease Ontology:DOID:264); acute kidney failure (Disease Ontology:DOID:3021); central nervous system cancer (Disease Ontology:DOID:3620); chronic myeloid leukemia (Disease Ontology:DOID:8552)",
        "pathway": " (hsa:3280);  (R-HSA-210744);  (R-HSA-2122947);  (R-HSA-2197563);  (R-HSA-2644606);  (R-HSA-2894862);  (R-HSA-8940973);  (R-HSA-8941856);  (R-HSA-9013508);  (R-HSA-9013695)",
        "pathway_count": 10,
        "publication_count": 172,
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        "class_list": "",
        "function": "Emergence of the ZNF675 Gene During Primate Evolution-Influenced Human Neurodevelopment Through Changing HES1 Autoregulation., [RefSeq, PubMed]; LINC MIR503HG Controls SC-beta Cell Differentiation and Insulin Production by Targeting CDH1 and HES1., [RefSeq, PubMed]; Loss of HES1 expression is associated with extracellular matrix remodeling and tumor immune suppression in KRAS mutant colon adenocarcinomas. Publication Status: Online-Only, [RefSeq, PubMed]; MLL1 inhibits the neurogenic potential of SCAPs by interacting with WDR5 and repressing HES1. Publication Status: Online-Only, [RefSeq, PubMed]; RIP140 regulates transcription factor HES1 oscillatory expression and mitogenic activity in colon cancer cells., [RefSeq, PubMed]; This protein belongs to the basic helix-loop-helix family of transcription factors. It is a transcriptional repressor of genes that require a bHLH protein for their transcription. The protein has a particular type of basic domain that contains a helix interrupting protein that binds to the N-box rather than the canonical E-box. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "Q6FHB2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0042803 protein homodimerization activity;GO:0051087 protein-folding chaperone binding;GO:0042826 histone deacetylase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix;GO:0000785 chromatin",
        "go_biological_process": "GO:0043279 response to alkaloid;GO:1904010 response to Aroclor 1254;GO:2000981 negative regulation of inner ear receptor cell differentiation;GO:0090281 negative regulation of calcium ion import;GO:0021861 forebrain radial glial cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 17.6,
        "record_id": "Q14469-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14CZ8-1",
        "uniprot_id": [
            {
                "id": "HECAM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14CZ8",
                "type": "external"
            }
        ],
        "mass": 46026.0,
        "length": 416,
        "protein_name": "Hepatic and glial cell adhesion molecule",
        "gene_name": "HEPACAM",
        "organism": "Human",
        "refseq_name": "hepatic and glial cell adhesion molecule isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_689935",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689935",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEPACAM",
        "gene_names_refseq": "GlialCAM; HEPACAM; MLC2A; MLC2B",
        "protein_names_uniprotkb": "Hepatic and glial cell adhesion molecule; Hepatocyte cell adhesion molecule; Protein hepaCAM; glialCAM",
        "protein_names_refseq": "hepatic and glial cell adhesion molecule isoform 1 precursor; hepatocyte cell adhesion molecule; protein hepaCAM",
        "tax_id": 9606,
        "disease": "megalencephalic leukoencephalopathy with subcortical cysts (Disease Ontology:DOID:0080315); megalencephalic leukoencephalopathy with subcortical cysts 2B (Disease Ontology:DOID:0080317); megalencephalic leukoencephalopathy with subcortical cysts 2A (Disease Ontology:DOID:0080318)",
        "pathway": " (hsa:220296)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "11237011;15885354;15917256;18082421;18293412;18510355;20166139;21419380;22328087;22405205;24715725;26621454;28657654;29557506;31154438;31960914;32335882;33024272;34592353;35051231;35073561;39531497",
        "class_list": "",
        "function": "Encodes an Ig-like transmembrane glycoprotein and is involved in cell adhesion and growth control, [RefSeq, PubMed]; GlialCAM, an immunoglobulin-like cell adhesion molecule is expressed in glial cells of the central nervous system., [RefSeq, PubMed]; Involved in regulating cell motility and cell-matrix interactions. May inhibit cell growth through suppression of cell proliferation (PubMed:15885354, PubMed:15917256). In glia, associates and targets CLCN2 at astrocytic processes and myelinated fiber tracts where it may regulate transcellular chloride flux involved in neuron excitability (PubMed:22405205)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Long noncoding RNA HOTAIR regulates the invasion and metastasis of prostate cancer by targeting hepaCAM., [RefSeq, PubMed]; Panobinostat reverses HepaCAM gene expression and suppresses proliferation by increasing histone acetylation in prostate cancer., [RefSeq, PubMed]; Structural basis for the dominant or recessive character of GLIALCAM mutations found in leukodystrophies., [RefSeq, PubMed]; Study examined the glycosylation of the GlialCAM (hepaCAM) extracellular domain expressed in HEK and CHO cells, [RefSeq, PubMed]; The cytoplasmic domain of hepaCAM is essential to its function on cell-matrix interaction and cell motility, [RefSeq, PubMed]; The heterozygous variant of the HEPACAM gene probably underlies the megalencephalic leukoencephalopathy with subcortical cyst in this child, [RefSeq, PubMed]; The protein encoded by this gene is a single-pass type I membrane protein that localizes to the cytoplasmic side of the cell membrane. The encoded protein acts as a homodimer and is involved in cell motility and cell-matrix interactions. The expression of this gene is downregulated or undetectable in many cancer cell lines, so this may be a tumor suppressor gene. [provided by RefSeq, Jul 2011]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q67IP8;Q6ZWL4;Q8N7I3;Q8ND35",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0097450 astrocyte end-foot",
        "go_biological_process": "GO:0150105 protein localization to cell-cell junction;GO:0006955 immune response;GO:0007155 cell adhesion;GO:0051726 regulation of cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q14CZ8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16777-1",
        "uniprot_id": [
            {
                "id": "H2A2C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16777",
                "type": "external"
            }
        ],
        "mass": 13988.0,
        "length": 129,
        "protein_name": "Histone H2A type 2-C",
        "gene_name": "H2AC20",
        "organism": "Human",
        "refseq_name": "histone H2A type 2-C",
        "refseq_ac": [
            {
                "id": "NP_003508",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003508",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2AC20; H2AFQ; HIST2H2AC",
        "gene_names_refseq": "H2A-GL101; H2A/q; H2AC20; H2AFQ; H2A; HIST2H2AC",
        "protein_names_uniprotkb": "Histone H2A type 2-C; H2A-clustered histone 20; Histone H2A-GL101; Histone H2A/q",
        "protein_names_refseq": "H2A histone family, member Q; histone 2, H2ac; histone H2A type 2-C; histone H2A-GL101; histone H2A/q; histone IIa; histone cluster 2 H2A family member c; histone cluster 2, H2ac",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8338);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-3214858);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-5689901);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 56,
        "publication_count": 1096,
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        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; HIV-Infected Patients: Cross Site-Specific Hydrolysis of H2a and H2b Histones and Myelin Basic Protein with Antibodies against These Three Proteins. Publication Status: Online-Only, [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. [provided by RefSeq, Aug 2015]., [RefSeq]; We found an excess of mutations in genes encoding histone H2A and H2B, as well as significant amplification of the segment of chromosome 6p harboring the histone gene cluster containing these genes.We also found frequent deletions of the genes TP53 and MBD3 (a member with CHD4 of the nucleosome remodeling deacetylase complex)., [RefSeq, PubMed]",
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        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
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        "hit_score": 109.9,
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    },
    {
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            {
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            }
        ],
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        "protein_name": "Hepatoma-derived growth factor-like protein 1",
        "gene_name": "HDGFL1",
        "organism": "Human",
        "refseq_name": "hepatoma-derived growth factor-like protein 1",
        "refseq_ac": [
            {
                "id": "NP_612641",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612641",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HDGFL1; PWWP1",
        "gene_names_refseq": "HDGFL1; HRP-1; Hdgfrp1; PWWP1; dJ309H15.1",
        "protein_names_uniprotkb": "Hepatoma-derived growth factor-like protein 1; PWWP domain-containing protein 1",
        "protein_names_refseq": "HDGF (hepatoma-derived growth factor) like; PWWP domain containing 1; PWWP domain-containing protein 1; hepatoma derived growth factor-like 1; hepatoma-derived growth factor-like protein 1; testicular tissue protein Li 84",
        "tax_id": 9606,
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        "pathway": " (hsa:154150)",
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        "class_list": "",
        "function": "The segment encompassed only one UCSC (University of California-Santa Cruz genome bioinformatics database) gene: HDGFL1 (Homo sapiens hepatoma derived growth factor like 1, GB #AL033539)., [RefSeq, PubMed]",
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    },
    {
        "uniprot_canonical_ac": "Q5VWC8-1",
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            {
                "id": "HACD4_HUMAN",
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                "type": "external"
            }
        ],
        "mass": 27520.0,
        "length": 232,
        "protein_name": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4",
        "gene_name": "HACD4",
        "organism": "Human",
        "refseq_name": "very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001010915",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010915",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HACD4; PTPLAD2",
        "gene_names_refseq": "HACD4; PTPLAD2",
        "protein_names_uniprotkb": "Very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4; 3-hydroxyacyl-CoA dehydratase 4; 4.2.1.134; HACD4; Protein-tyrosine phosphatase-like A domain-containing protein 2",
        "protein_names_refseq": "protein tyrosine phosphatase-like A domain containing 2; protein tyrosine phosphatase-like protein PTPLAD2; protein-tyrosine phosphatase-like A domain-containing protein 2; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4 isoform 1; very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase 4; very-long-chain (3R)-3-hydroxyacyl-[acyl-carrier protein] dehydratase 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:401494);  (R-HSA-75876)",
        "pathway_count": 2,
        "publication_count": 41,
        "publication_id_list": "10548543;10954726;11889465;12371743;12482854;12525535;12975357;15469937;16036915;16371355;17379924;17681178;17762044;18003621;18554506;18728184;19505953;19826053;20937905;21959040;24530685;24715725;25576301;25880248;26154972;27862975;28904123;29031776;29493099;29532408;29557506;31217245;31844290;32357974;32387766;32938616;35051231;35580925;36284347;37938771;8075637",
        "class_list": "",
        "function": "Association of HACD4 haplotypes with atherosclerotic phenotypes connotes a further validation and replication in larger cohorts as well as functional studies to enlighten the potential mechanism of its action in pathophysiology of atherosclerosis., [RefSeq, PubMed]; Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates in the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators., [UniProtKB, PubMed]; Inactivating Frameshift Mutations of HACD4 and TCP10L Tumor Suppressor Genes in Colorectal and Gastric Cancers., [RefSeq, PubMed]; PTPLAD2 is a potential tumor suppressor and prognostic indicator that reduces STAT3 phosphorylation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q7Z385",
        "ec_number_list": [
            {
                "id": "4.2.1.134",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.134",
                "type": "external"
            },
            {
                "id": "1.1.1.n12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.n12",
                "type": "external"
            },
            {
                "id": "4.2.1.107",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.107",
                "type": "external"
            },
            {
                "id": "4.2.1.119",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.119",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0018812 3-hydroxyacyl-CoA dehydratase activity;GO:0102158 very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0030148 sphingolipid biosynthetic process;GO:0030497 fatty acid elongation;GO:0042761 very long-chain fatty acid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q5VWC8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6DN03-1",
        "uniprot_id": [
            {
                "id": "H2B2C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6DN03",
                "type": "external"
            }
        ],
        "mass": 21472.0,
        "length": 193,
        "protein_name": "Putative histone H2B type 2-C",
        "gene_name": "H2BC20P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "H2BC20P; HIST2H2BC",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative histone H2B type 2-C; H2B-clustered histone 20 pseudogene; H2B/t; Histone H2B.t",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
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        "pathway_count": 0,
        "publication_count": 22,
        "publication_id_list": "12408966;12757711;15527963;16283522;18160138;21925322;22389435;23481700;24681537;24715725;27105113;27105115;28467828;30154464;31542297;31844290;32387766;33298915;33936100;34087483;34545082;34961760",
        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]",
        "predicted_glycosites": 1,
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        "secondary_ac_list": "B7Z677",
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        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0000786 nucleosome",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q6DN03-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6FI13-1",
        "uniprot_id": [
            {
                "id": "H2A2A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6FI13",
                "type": "external"
            }
        ],
        "mass": 14095.0,
        "length": 130,
        "protein_name": "Histone H2A type 2-A",
        "gene_name": "H2AC18; H2AC19",
        "organism": "Human",
        "refseq_name": "histone H2A type 2-A",
        "refseq_ac": [
            {
                "id": "NP_001035807",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035807",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2AC18; H2AC19; H2AFO; HIST2H2AA3; HIST2H2AA4; HIST2H2AA",
        "gene_names_refseq": "H2A/R; H2AC19; HIST2H2AA4",
        "protein_names_uniprotkb": "Histone H2A type 2-A; H2A-clustered histone 18; H2A-clustered histone 19; Histone H2A.2; Histone H2A/o",
        "protein_names_refseq": "histone 2, H2aa4; histone H2A type 2-A; histone H2A/r; histone cluster 2 H2A family member a4; histone cluster 2, H2aa4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:723790);  (hsa:8337);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-3214858);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-5689901);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 57,
        "publication_count": 1095,
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        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in a histone cluster on chromosome 1. This gene is one of four histone genes in the cluster that are duplicated; this record represents the telomeric copy. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5F0;P20670",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0031507 heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 109.8,
        "record_id": "Q6FI13-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7L7L0-1",
        "uniprot_id": [
            {
                "id": "H2A3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7L7L0",
                "type": "external"
            }
        ],
        "mass": 14121.0,
        "length": 130,
        "protein_name": "Histone H2A type 3",
        "gene_name": "H2AC25",
        "organism": "Human",
        "refseq_name": "histone H2A type 3",
        "refseq_ac": [
            {
                "id": "NP_254280",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_254280",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2AC25; H2AW; HIST3H2A",
        "gene_names_refseq": "H2AC25; H2AW; HIST3H2A",
        "protein_names_uniprotkb": "Histone H2A type 3; H2A-clustered histone 25",
        "protein_names_refseq": "H2A.W histone; histone 3, H2a; histone H2A type 3; histone cluster 3 H2A; histone cluster 3, H2a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92815);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-3214858);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-5689901);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9918481)",
        "pathway_count": 10,
        "publication_count": 183,
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        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; HIST3H2A promotes the progression of prostate cancer through inhibiting cell necroptosis. Publication Status: Online-Only, [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]; Overexpression of HIST3H2A reversed the anti-proliferation effects induced by miR-516a-5p in non-small cell lung cancer cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "reported_mutagensis": 1,
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        "reported_snv": 4,
        "reported_interactions": 0,
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        "biomarker_type": "",
        "glycan_count": 1,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4S4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0006337 nucleosome disassembly;GO:0070914 UV-damage excision repair;GO:0031507 heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 18.6,
        "record_id": "Q7L7L0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
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    },
    {
        "uniprot_canonical_ac": "Q8IUE6-1",
        "uniprot_id": [
            {
                "id": "H2A2B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IUE6",
                "type": "external"
            }
        ],
        "mass": 13995.0,
        "length": 130,
        "protein_name": "Histone H2A type 2-B",
        "gene_name": "H2AC21",
        "organism": "Human",
        "refseq_name": "histone H2A type 2-B",
        "refseq_ac": [
            {
                "id": "NP_778235",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778235",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2AC21; HIST2H2AB",
        "gene_names_refseq": "H2AB; H2AC21; HIST2H2AB",
        "protein_names_uniprotkb": "Histone H2A type 2-B; H2A-clustered histone 21",
        "protein_names_refseq": "histone 2, H2ab; histone H2A type 2-B; histone cluster 2 H2A family member b; histone cluster 2, H2ab",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:317772);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-3214858);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-5689901);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9918481)",
        "pathway_count": 10,
        "publication_count": 190,
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        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0031507 heterochromatin formation",
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        "hit_score": 19.3,
        "record_id": "Q8IUE6-1",
        "record_type": "protein",
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    {
        "uniprot_canonical_ac": "Q8IV16-1",
        "uniprot_id": [
            {
                "id": "HDBP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IV16",
                "type": "external"
            }
        ],
        "mass": 19850.0,
        "length": 184,
        "protein_name": "Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1",
        "gene_name": "GPIHBP1",
        "organism": "Human",
        "refseq_name": "glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001288701",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288701",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GPIHBP1; HBP1",
        "gene_names_refseq": "GPI-HBP1; GPIHBP1; HYPL1D",
        "protein_names_uniprotkb": "Glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1; GPI-HBP1; GPI-anchored HDL-binding protein 1; High density lipoprotein-binding protein 1",
        "protein_names_refseq": "GPI anchored high density lipoprotein binding protein 1; GPI-anchored HDL-binding protein 1; endothelial cell LPL transporter; glycosylphosphatidylinositol-anchored high density lipoprotein-binding protein 1 isoform 2 precursor",
        "tax_id": 9606,
        "disease": "familial GPIHBP1 deficiency (Disease Ontology:DOID:0111420)",
        "pathway": " (hsa:338328);  (R-HSA-163125);  (R-HSA-8963889);  (R-HSA-8963901);  (R-HSA-975634)",
        "pathway_count": 5,
        "publication_count": 94,
        "publication_id_list": "10052934;10769148;10900462;11060341;11072085;11181758;11274389;1279089;1301939;15284087;15358783;1542003;15583000;15800215;16109723;16200213;16939223;17088546;17525477;17644776;17883852;17994020;17997385;18087047;18295589;18460466;18507396;1856611;19014918;19139408;19304573;19361614;20026666;20356926;20581395;21106934;21314738;21518912;21666694;21719679;21816778;21844202;21851338;22008945;22239554;22262056;22569073;22740495;23020258;23150577;23831619;24106281;24397894;2443973;24909692;24960069;25387803;26725083;26933753;26934567;26934667;27578123;27811232;27929370;2793848;29899144;30559189;31154438;31848261;3422494;35101360;36037340;3714052;37871217;38622573;3942763;4345202;5057882;5675424;6420172;6961410;7592670;7683668;8017323;8020465;8300609;8384721;8485124;8728311;9136889;9379936;9888420;9920938;9925661",
        "class_list": "",
        "function": "A protein of capillary endothelial cells, GPIHBP1, is crucial for plasma triglyceride metabolism., [RefSeq, PubMed]; A very rare GPIHBP1 missense mutation appears to be associated with severe hypertriglyceridemia and chylomicronemia. Publication Status: Online-Only, [RefSeq, PubMed]; Analysis of a neonate with complete GPIHBP1 deficiency due to homozygosity for a deletion of GPIHBP1 [case report], [RefSeq, PubMed]; Circulating GPIHBP1 levels and microvascular complications in patients with type 2 diabetes: A cross-sectional study., [RefSeq, PubMed]; Data show that the G56R substitution did not affect the ability of GPIHBP1 to reach the cell surface, nor did the amino acid substitution have any discernible effect on the binding of lipoprotein lipase, chylomicrons, or apo-AV., [RefSeq, PubMed]; Familial chylomicronemia syndrome: case reports of siblings with deletions of the GPIHBP1 gene. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (By similarity). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (By similarity). Protects LPL against loss of activity, and against ANGPTL4-mediated unfolding (PubMed:27929370, PubMed:29899144). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:19304573, PubMed:21314738). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:17997385, PubMed:19304573). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Report that two LPL missense mutations initially identified in patients with chylomicronemia, C418Y and E421K, abolish LPL's ability to bind to GPIHBP1 without interfering with LPL catalytic activity or binding to heparin, [RefSeq, PubMed]; The lipoprotein lipase that is shuttled into capillaries by GPIHBP1 enters the glycocalyx where it mediates lipoprotein processing., [RefSeq, PubMed]; This gene encodes a capillary endothelial cell protein that facilitates the lipolytic processing of triglyceride-rich lipoproteins. The encoded protein is a glycosylphosphatidylinositol-anchored protein that is a member of the lymphocyte antigen 6 (Ly6) family. This protein plays a major role in transporting lipoprotein lipase (LPL) from the subendothelial spaces to the capillary lumen. Mutations in this gene are the cause of hyperlipoproteinemia, type 1D. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Sep 2014]., [RefSeq]",
        "predicted_glycosites": 0,
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        "total_reported_n_glycosites": 1,
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        "reported_mutagensis": 22,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6P3T2;Q86W15",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008289 lipid binding;GO:0035473 lipase binding;GO:0060230 lipoprotein lipase activator activity;GO:0071813 lipoprotein particle binding;GO:0035478 chylomicron binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042632 cholesterol homeostasis;GO:0050821 protein stabilization;GO:0019433 triglyceride catabolic process;GO:0045723 positive regulation of fatty acid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.6,
        "record_id": "Q8IV16-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000000000.100.00000",
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    },
    {
        "uniprot_canonical_ac": "Q8IZA3-1",
        "uniprot_id": [
            {
                "id": "H18_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IZA3",
                "type": "external"
            }
        ],
        "mass": 35813.0,
        "length": 346,
        "protein_name": "Histone H1.8",
        "gene_name": "H1-8",
        "organism": "Human",
        "refseq_name": "histone H1.8 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001295191",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295191",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H1-8; H1FOO; H1OO; OSH1",
        "gene_names_refseq": "H1-8; H1.8; H1FOO; H1oo; osH1",
        "protein_names_uniprotkb": "Histone H1.8; Histone H1oo; Oocyte-specific histone H1; Oocyte-specific linker histone H1; osH1",
        "protein_names_refseq": "H1 histone family member O oocyte specific; histone H1.8 isoform 2; histone H1.8; histone H1oo; oocyte-specific histone H1; oocyte-specific linker histone H1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:132243);  (R-HSA-9821993)",
        "pathway_count": 2,
        "publication_count": 5,
        "publication_id_list": "12711322;19147139;22362753;29786170;36215666",
        "class_list": "",
        "function": "After intracytoplasmic sperm injection, the assembly of H1FOO on sperm chromatin during decondensation seems to occur very quickly, and hH1FOO protein is localized in all oocytes from primordial to Graafian follicles., [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. The protein encoded is a replication-independent histone that is a member of the histone H1 family. This gene contains introns, unlike most histone genes. The related mouse gene is expressed only in oocytes. [provided by RefSeq, Oct 2015]., [RefSeq]; May play a key role in the control of gene expression during oogenesis and early embryogenesis, presumably through the perturbation of chromatin structure. Essential for meiotic maturation of germinal vesicle-stage oocytes. The somatic type linker histone H1c is rapidly replaced by H1oo in a donor nucleus transplanted into an oocyte. The greater mobility of H1oo as compared to H1c may contribute to this rapid replacement and increased instability of the embryonic chromatin structure. The rapid replacement of H1c with H1oo may play an important role in nuclear remodeling (By similarity)., [UniProtKB]; Structure and gene expression of osH1., [RefSeq, PubMed]",
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        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86WT7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003690 double-stranded DNA binding;GO:0031492 nucleosomal DNA binding;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0006334 nucleosome assembly;GO:0030261 chromosome condensation;GO:0040029 epigenetic regulation of gene expression;GO:0045910 negative regulation of DNA recombination;GO:0051321 meiotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q8IZA3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IZP7-1",
        "uniprot_id": [
            {
                "id": "H6ST3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IZP7",
                "type": "external"
            }
        ],
        "mass": 54844.0,
        "length": 471,
        "protein_name": "Heparan-sulfate 6-O-sulfotransferase 3",
        "gene_name": "HS6ST3",
        "organism": "Human",
        "refseq_name": "heparan-sulfate 6-O-sulfotransferase 3",
        "refseq_ac": [
            {
                "id": "NP_703157",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_703157",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HS6ST3",
        "gene_names_refseq": "HS6ST-3; HS6ST3",
        "protein_names_uniprotkb": "Heparan-sulfate 6-O-sulfotransferase 3; 2.8.2.-; HS6ST-3",
        "protein_names_refseq": "heparan-sulfate 6-O-sulfotransferase 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:266722);  (R-HSA-2022928)",
        "pathway_count": 2,
        "publication_count": 33,
        "publication_id_list": "10.1038/emboj.2013.79;10318803;10639137;10644753;10677367;10716625;11087757;11169766;11274177;11279150;11390981;12138164;12492399;15082721;15607426;16343444;20554947;21700882;23584533;24371161;25802875;28017727;28132690;28148688;30471091;33159882;35676258;7601448;9346953;9463333;9535912;9915799;9988767",
        "class_list": "glycogene",
        "function": "6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate., [UniProtKB]; Heparan sulfate (HS) sulfotransferases, such as HS6ST3, modify HS to generate structures required for interactions between HS and a variety of proteins. These interactions are implicated in proliferation and differentiation, adhesion, migration, inflammation, blood coagulation, and other diverse processes (Habuchi et al., 2000 [PubMed 10644753]).[supplied by OMIM, Mar 2008]., [RefSeq]; Silencing HS6ST3 diminished tumor cell growth and progression in breast cancer cells.  Silencing HS6ST3 down-regulated IGF1R and up-regulated XAF1., [RefSeq, PubMed]; Single-nucleotide polymorphisms within the HS6ST3 gene are associated with obesity and triglyceride levels. [Meta-analysis], [RefSeq, PubMed]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 633,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5W0L0;Q68CW6",
        "ec_number_list": [
            {
                "id": "2.8.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0017095 heparan sulfate 6-sulfotransferase activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane",
        "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q8IZP7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000011000.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N257-1",
        "uniprot_id": [
            {
                "id": "H2B3B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N257",
                "type": "external"
            }
        ],
        "mass": 13908.0,
        "length": 126,
        "protein_name": "Histone H2B type 3-B",
        "gene_name": "H2BC26",
        "organism": "Human",
        "refseq_name": "histone H2B type 3-B",
        "refseq_ac": [
            {
                "id": "NP_778225",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778225",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2BC26; H2BU1; HIST3H2BB",
        "gene_names_refseq": "H2BC26; H2BU1; H2Bb; HIST3H2BB",
        "protein_names_uniprotkb": "Histone H2B type 3-B; H2B type 12; H2B-clustered histone 26; H2B.U histone 1",
        "protein_names_refseq": "H2B type 12; H2B.U histone 1; histone 3, H2bb; histone H2B type 3-B; histone cluster 3 H2B family member b; histone cluster 3, H2bb",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:128312);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5689880);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-69473);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9821993);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 58,
        "publication_count": 1230,
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        "class_list": "",
        "function": "ATM-dependent monoubiquitylation of histone H2B is required for timely repair of DNA double-strand breaks, [RefSeq, PubMed]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]; Infertile men have a higher proportion of spermatozoa with diffuse histone H2B, [RefSeq, PubMed]; The present findings provide evidence indicating that the extrachromosomal histone H2B is engaged in the signaling pathway initiated by dsDNA to trigger antiviral innate immune responses., [RefSeq, PubMed]; USP7 can stimulate EBNA1-DNA interactions and EBNA1 can alter histone modification at oriP through recruitment of USP7., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
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        "total_reported_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4FU05;Q3ZCP6;Q5TA30",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000786 nucleosome",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0002227 innate immune response in mucosa",
        "synthesized_glycan_count": 0,
        "hit_score": 123.3,
        "record_id": "Q8N257-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96JB3-1",
        "uniprot_id": [
            {
                "id": "HIC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96JB3",
                "type": "external"
            }
        ],
        "mass": 66156.0,
        "length": 615,
        "protein_name": "Hypermethylated in cancer 2 protein",
        "gene_name": "HIC2",
        "organism": "Human",
        "refseq_name": "hypermethylated in cancer 2 protein",
        "refseq_ac": [
            {
                "id": "NP_055909",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055909",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HIC2; HRG22; KIAA1020; ZBTB30",
        "gene_names_refseq": "HIC2; HRG22; ZBTB30; ZNF907",
        "protein_names_uniprotkb": "Hypermethylated in cancer 2 protein; HIC1-related gene on chromosome 22 protein; Hic-2; Hic-3; Zinc finger and BTB domain-containing protein 30",
        "protein_names_refseq": "HIC1-related gene on chromosome 22 protein; hic-2; hic-3; hypermethylated in cancer 2 protein; zinc finger and BTB domain-containing protein 30",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23119)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "11554746;19651622;23186163;26992070;29242379;29632711;30315122;31127867;31844290;33592498;33912179;33936100;34357683;35941187;36650953;38364109",
        "class_list": "",
        "function": "HIC1 and HRG22 define a subgroup of BTB/POZ domains unable to recruit repressing complexes containing a histone deacetylase activity., [RefSeq, PubMed]; HIC2 controls developmental hemoglobin switching by repressing BCL11A transcription. Erratum:[Nat Genet. 2023 Sep;55(9):1608. doi: 10.1038/s41588-023-01488-7. PMID: 37524792], [RefSeq, PubMed]; HIC2 is a pivotal transcriptional activator of SIRT1, [RefSeq, PubMed]; Hypermethylation of HIC2 is a potential prognostic biomarker and tumor suppressor of glioma based on bioinformatics analysis and experiments., [RefSeq, PubMed]; Let-7 miRNAs repress HIC2 to regulate BCL11A transcription and hemoglobin switching., [RefSeq, PubMed]; Transcriptional repressor., [UniProtKB]",
        "predicted_glycosites": 1,
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        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
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        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q504T6;Q96KR3;Q9NSM9;Q9UPX9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0002682 regulation of immune system process;GO:0001817 regulation of cytokine production",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q96JB3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96QV6-1",
        "uniprot_id": [
            {
                "id": "H2A1A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96QV6",
                "type": "external"
            }
        ],
        "mass": 14234.0,
        "length": 131,
        "protein_name": "Histone H2A type 1-A",
        "gene_name": "H2AC1",
        "organism": "Human",
        "refseq_name": "histone H2A type 1-A",
        "refseq_ac": [
            {
                "id": "NP_734466",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_734466",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2AC1; H2AFR; HIST1H2AA",
        "gene_names_refseq": "H2AA; H2AC1; H2AFR; HIST1H2AA; HISTH2AA; TH2A; bA317E16.2",
        "protein_names_uniprotkb": "Histone H2A type 1-A; H2A-clustered histone 1; Histone H2A/r",
        "protein_names_refseq": "H2A histone family, member R; histone 1, H2aa; histone H2A type 1-A; histone H2A/r; histone cluster 1 H2A family member a; histone cluster 1, H2aa",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:221613);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-3214858);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-5689901);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9918481)",
        "pathway_count": 10,
        "publication_count": 191,
        "publication_id_list": "10.1101/2023.09.13.557529;10383417;10444327;10444591;10449787;10479050;10748112;10786633;10821277;10904264;10922406;10926844;10982817;11341840;11448779;11466336;11509652;11566882;11739383;11742974;11747608;11747826;11751582;11756452;11909966;11923872;12032298;12353037;12408966;12724404;12857923;12917689;12917691;14519844;14661020;14762106;15010469;15053880;15078818;15084397;15313887;15386022;15485929;15823041;15916963;16140760;16214042;16359901;16387653;16702407;16901786;16906146;16964248;17139257;17211407;17215844;17290220;17443180;17707232;17873522;17898714;17980597;17981138;18001824;18001825;18079182;18172164;18203656;18381289;18404153;18467330;18497827;18535146;18623064;18632802;18636086;18758443;19015242;19135894;19187765;19188362;19188440;19202061;19203578;19203579;19234465;19363159;19398555;19424180;19640981;19682613;19815555;19838211;19874889;19910467;20018852;20096447;20228808;20368735;20436459;20501646;20805357;20951943;21239494;21316606;21362556;21571647;21587264;21596315;21659512;21690215;21774791;21849505;21911577;21925322;21962518;22029577;22085928;22128162;22174689;22216260;22231400;22389435;22713238;22980979;23159851;23246432;23395819;23481700;23486064;23824326;23825189;24056413;24140421;24260525;24352239;24493797;24681537;24896179;25197364;25305019;2530630;25418920;25470042;25578727;25645385;26092250;26101246;26154972;26375851;26572645;26929215;27083998;27105115;27108190;27501258;27726376;27941757;28410146;28415052;29508533;29902443;30154464;30192525;30360396;30599162;30761409;31542297;31844290;33091337;33177556;33392160;33691108;33968037;34545082;34961760;35215846;36010968;37217939;40914422;7513682;7578059;9150135;9427644;9528852;9558366;9642256;9651585;9790534;9790970;9880483",
        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Data indicate that formalin-fixed, paraffin-embedded (FFPE) tissue processing may result in persistent chemical modifications of histones, which correspond in mass shift of important post-translational modifications (PTMs)., [RefSeq, PubMed]; Findings show that serine-threonine-tyrosine kinase 1 (NOK) mediates glycolysis and nuclear pyruvate dehydrogenase complex (PDC) associated histone acetylation. Publication Status: Online-Only, [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene contain a palindromic termination element. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000781 chromosome, telomeric region;GO:0000786 nucleosome",
        "go_biological_process": "GO:0031507 heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 19.6,
        "record_id": "Q96QV6-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99075-1",
        "uniprot_id": [
            {
                "id": "HBEGF_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99075",
                "type": "external"
            }
        ],
        "mass": 23067.0,
        "length": 208,
        "protein_name": "Proheparin-binding EGF-like growth factor",
        "gene_name": "HBEGF",
        "organism": "Human",
        "refseq_name": "proheparin-binding EGF-like growth factor precursor",
        "refseq_ac": [
            {
                "id": "NP_001936",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001936",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HBEGF; DTR; DTS; HEGFL",
        "gene_names_refseq": "DTR; DTSF; DTS; HBEGF; HEGFL",
        "protein_names_uniprotkb": "Proheparin-binding EGF-like growth factor; DT-R; Diphtheria toxin receptor",
        "protein_names_refseq": "diphtheria toxin receptor (heparin-binding EGF-like growth factor); diphtheria toxin receptor (heparin-binding epidermal growth factor-like growth factor); proheparin-binding EGF-like growth factor precursor; proheparin-binding EGF-like growth factor",
        "tax_id": 9606,
        "disease": "glomerulosclerosis (Disease Ontology:DOID:0050851); acute kidney failure (Disease Ontology:DOID:3021); perinatal necrotizing enterocolitis (Disease Ontology:DOID:8677)",
        "pathway": " (hsa:1839);  (R-HSA-1227986);  (R-HSA-1236394);  (R-HSA-1250196);  (R-HSA-1250342);  (R-HSA-1250347);  (R-HSA-1251985);  (R-HSA-1257604);  (R-HSA-177929);  (R-HSA-179812);  (R-HSA-180292);  (R-HSA-180336);  (R-HSA-182971);  (R-HSA-1963640);  (R-HSA-1963642);  (R-HSA-212718);  (R-HSA-2179392);  (R-HSA-2219530);  (R-HSA-5336415);  (R-HSA-5638303);  (R-HSA-5673001);  (R-HSA-6785631);  (R-HSA-6811558);  (R-HSA-8847993);  (R-HSA-8856825);  (R-HSA-8856828);  (R-HSA-8857538);  (R-HSA-8863795);  (R-HSA-9009391);  (R-HSA-9634638);  (R-HSA-9664565);  (R-HSA-9665686)",
        "pathway_count": 32,
        "publication_count": 621,
        "publication_id_list": 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        "class_list": "",
        "function": "Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor., [UniProtKB]; HBEGF-TNF induce a complex outer retinal pathology with photoreceptor cell extrusion in human organoids. Publication Status: Online-Only, [RefSeq, PubMed]; MicroRNA-194 is increased in polycystic ovary syndrome granulosa cell and induce KGN cells apoptosis by direct targeting heparin-binding EGF-like growth factor. Publication Status: Online-Only, [RefSeq, PubMed]; Spinal cord repair is modulated by the neurogenic factor Hb-egf under direction of a regeneration-associated enhancer. Publication Status: Online-Only, [RefSeq, PubMed]; The Multiple Functions of HB-EGF in Female Reproduction and Related Cancer: Molecular Mechanisms and Targeting Strategies. Review article, [RefSeq, PubMed]; The astrocyte-produced growth factor HB-EGF limits autoimmune CNS pathology., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 6,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 10,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 11,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 11,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 3,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R821",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008201 heparin binding;GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0030666 endocytic vesicle membrane",
        "go_biological_process": "GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation;GO:0030307 positive regulation of cell growth;GO:0030335 positive regulation of cell migration;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 63.9,
        "record_id": "Q99075-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100010000001.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99877-1",
        "uniprot_id": [
            {
                "id": "H2B1N_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99877",
                "type": "external"
            }
        ],
        "mass": 13922.0,
        "length": 126,
        "protein_name": "Histone H2B type 1-N",
        "gene_name": "H2BC15",
        "organism": "Human",
        "refseq_name": "histone H2B type 1-N",
        "refseq_ac": [
            {
                "id": "NP_003511",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003511",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2BC15; H2BFD; HIST1H2BN",
        "gene_names_refseq": "H2B/d; H2BC15; H2BFD; HIST1H2BN",
        "protein_names_uniprotkb": "Histone H2B type 1-N; H2B/d; Histone H2B.d",
        "protein_names_refseq": "H2B histone family, member D; histone 1, H2bn; histone H2B type 1-N; histone H2B.d; histone cluster 1 H2B family member n; histone cluster 1, H2bn",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8341);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5689880);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-69473);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8866654);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9821993);  (R-HSA-9833110);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 60,
        "publication_count": 1246,
        "publication_id_list": 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        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]., [RefSeq]; Hypomethylation of ATG4A and HIST1H2BN in ovarian tumor-initiating cells predicts a poor prognosis for ovarian cancer patients., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5L4;Q494S8;Q96FB7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0002227 innate immune response in mucosa",
        "synthesized_glycan_count": 0,
        "hit_score": 124.9,
        "record_id": "Q99877-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99878-1",
        "uniprot_id": [
            {
                "id": "H2A1J_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99878",
                "type": "external"
            }
        ],
        "mass": 13936.0,
        "length": 128,
        "protein_name": "Histone H2A type 1-J",
        "gene_name": "H2AC14",
        "organism": "Human",
        "refseq_name": "histone cluster 1, H2aj",
        "refseq_ac": [
            {
                "id": "NP_066544",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066544",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2AC14; H2AFE; HIST1H2AJ",
        "gene_names_refseq": "H2A/E; H2AC14; H2AFE; HIST1H2AJ; dJ160A22.4",
        "protein_names_uniprotkb": "Histone H2A type 1-J; Histone H2A/e",
        "protein_names_refseq": "H2A histone family, member E; histone 1, H2aj; histone cluster 1 H2A family member j; histone cluster 1, H2aj",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8331);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-3214858);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5689603);  (R-HSA-5689880);  (R-HSA-5689901);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 56,
        "publication_count": 1090,
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        "class_list": "",
        "function": "Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2A family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RUU6;Q5JXQ5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0031507 heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 109.3,
        "record_id": "Q99878-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99880-1",
        "uniprot_id": [
            {
                "id": "H2B1L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99880",
                "type": "external"
            }
        ],
        "mass": 13952.0,
        "length": 126,
        "protein_name": "Histone H2B type 1-L",
        "gene_name": "H2BC13",
        "organism": "Human",
        "refseq_name": "histone H2B type 1-L",
        "refseq_ac": [
            {
                "id": "NP_003510",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003510",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "H2BC13; H2BFC; HIST1H2BL",
        "gene_names_refseq": "H2B/c; H2BC13; H2BFC; HIST1H2BL; dJ97D16.4",
        "protein_names_uniprotkb": "Histone H2B type 1-L; H2B/c; Histone H2B.c",
        "protein_names_refseq": "H2B histone family, member C; histone 1, H2bl; histone H2B type 1-L; histone H2B.c; histone cluster 1 H2B family member l; histone cluster 1, H2bl",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8340);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-1221632);  (R-HSA-171306);  (R-HSA-1912408);  (R-HSA-201722);  (R-HSA-212300);  (R-HSA-2299718);  (R-HSA-2559580);  (R-HSA-2559582);  (R-HSA-2559586);  (R-HSA-3214815);  (R-HSA-3214847);  (R-HSA-427359);  (R-HSA-427389);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-5334118);  (R-HSA-5578749);  (R-HSA-5617472);  (R-HSA-5625886);  (R-HSA-5689880);  (R-HSA-5693565);  (R-HSA-5693571);  (R-HSA-5693607);  (R-HSA-606279);  (R-HSA-68616);  (R-HSA-69473);  (R-HSA-73728);  (R-HSA-73772);  (R-HSA-8866654);  (R-HSA-8936459);  (R-HSA-8939236);  (R-HSA-9018519);  (R-HSA-912446);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9616222);  (R-HSA-9670095);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-977225);  (R-HSA-9821002);  (R-HSA-9821993);  (R-HSA-9841922);  (R-HSA-9843940);  (R-HSA-9843970);  (R-HSA-9845323);  (R-HSA-9909649);  (R-HSA-9918481);  (R-HSA-9937850);  (R-HSA-9940465);  (R-HSA-9940951);  (R-HSA-9943411);  (R-HSA-9943962);  (R-HSA-9970672)",
        "pathway_count": 59,
        "publication_count": 1262,
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        "class_list": "",
        "function": "A protein encoded by this locus was found to be differentially expressed in postmortem brains from patients with atypical frontotemporal lobar degeneration., [RefSeq, PubMed]; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling., [UniProtKB]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Two molecules of each of the four core histones (H2A, H2B, H3, and H4) form an octamer, around which approximately 146 bp of DNA is wrapped in repeating units, called nucleosomes. The linker histone, H1, interacts with linker DNA between nucleosomes and functions in the compaction of chromatin into higher order structures. This gene is intronless and encodes a replication-dependent histone that is a member of the histone H2B family. Transcripts from this gene lack polyA tails but instead contain a palindromic termination element. This gene is found in the small histone gene cluster on chromosome 6p22-p21.3. [provided by RefSeq, Aug 2015]., [RefSeq]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5A3;Q52LW9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0030527 structural constituent of chromatin",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000786 nucleosome",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0061844 antimicrobial humoral immune response mediated by antimicrobial peptide;GO:0006325 chromatin organization;GO:0006334 nucleosome assembly;GO:0002227 innate immune response in mucosa",
        "synthesized_glycan_count": 0,
        "hit_score": 126.8,
        "record_id": "Q99880-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BXC0-1",
        "uniprot_id": [
            {
                "id": "HCAR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BXC0",
                "type": "external"
            }
        ],
        "mass": 39295.0,
        "length": 346,
        "protein_name": "Hydroxycarboxylic acid receptor 1",
        "gene_name": "HCAR1",
        "organism": "Human",
        "refseq_name": "hydroxycarboxylic acid receptor 1",
        "refseq_ac": [
            {
                "id": "NP_115943",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115943",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HCAR1; FKSG80; GPR104; GPR81; HCA1",
        "gene_names_refseq": "FKSG80; GPR104; GPR81; HCA1; HCAR1; LACR1; TA-GPCR; TAGPCR",
        "protein_names_uniprotkb": "Hydroxycarboxylic acid receptor 1; G protein-coupled receptor 104; G protein-coupled receptor 81",
        "protein_names_refseq": "G protein-coupled receptor 104; G-protein coupled receptor 81; T-cell activation G protein-coupled receptor; hydroxy-carboxylic acid receptor 1; hydroxycarboxylic acid receptor 1; lactate receptor 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27198);  (R-HSA-3296197);  (R-HSA-418594)",
        "pathway_count": 3,
        "publication_count": 26,
        "publication_id_list": "11007482;11574155;12044878;12120503;15951850;16634148;16923326;18434541;18577758;18952058;19047060;19561068;21454438;2534964;25576301;2748346;2834384;28832583;37698122;38334628;38427215;38909565;40233099;7937899;8015379;8406495",
        "class_list": "",
        "function": "Activation of GPR81 aggravated intestinal ischemia/reperfusion injury-induced acute lung injury via HMGB1-mediated neutrophil extracellular traps formation., [RefSeq, PubMed]; Acts as a receptor for L-lactate and mediates its anti-lipolytic effect through a G(i)-protein-mediated pathway., [UniProtKB, PubMed]; G protein-coupled receptors (GPCRs, or GPRs), such as GPR81, contain 7 transmembrane domains and transduce extracellular signals through heterotrimeric G proteins.[supplied by OMIM, Feb 2005]., [RefSeq]; GPR81 with relatively restricted expression in the adipose tissues functions as a receptor for lactate and can mediate an anti-lipolytic effect of lactate., [RefSeq, PubMed]; High Glucose Levels Promote Switch to Synthetic Vascular Smooth Muscle Cells via Lactate/GPR81. Publication Status: Online-Only, [RefSeq, PubMed]; Immunohistochemical localization of HCA1 receptor in placenta in presence of fetal growth restriction., [RefSeq, PubMed]; Lactate/Hydroxycarboxylic Acid Receptor 1 in Alzheimer's Disease: Mechanisms and Therapeutic Implications-Exercise Perspective. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9X4;Q3Y5J3;Q4VBN1;Q6NXU5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0050995 negative regulation of lipid catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q9BXC0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BYK8-1",
        "uniprot_id": [
            {
                "id": "HELZ2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BYK8",
                "type": "external"
            }
        ],
        "mass": 322316.0,
        "length": 2896,
        "protein_name": "3'-5' exoribonuclease HELZ2",
        "gene_name": "HELZ2",
        "organism": "Human",
        "refseq_name": "3'-5' exoribonuclease HELZ2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001032412",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032412",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HELZ2; KIAA1769; PRIC285",
        "gene_names_refseq": "HELZ2; PDIP-1; PRIC285",
        "protein_names_uniprotkb": "3'-5' exoribonuclease HELZ2; 3.1.13.1; 5.6.2.6; ATP-dependent RNA helicase PRIC285; Helicase with zinc finger 2, transcriptional coactivator; Helicase with zinc finger domain 2; PDIP1; PPAR-alpha-interacting complex protein 285; PPAR-gamma DBD-interacting protein 1; PPAR-gamma DNA-binding domain-interacting protein 1; Peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein",
        "protein_names_refseq": "3'-5' exoribonuclease HELZ2 isoform 1; 3'-5' exoribonuclease HELZ2; ATP-dependent RNA helicase PRIC285; ATP-dependent helicase PRIC285; PDIP1; PPAR gamma DBD-interacting protein 1; PPAR-alpha-interacting complex protein 285; PPAR-gamma DNA-binding domain-interacting protein 1; PPARG-DBD-interacting protein 1; PPARgamma-DNA-binding domain-interacting protein1; PRIC complex; helicase with zinc finger 2, transcriptional coactivator; helicase with zinc finger domain 2; peroxisomal proliferator-activated receptor A interacting complex 285; peroxisomal proliferator-activated receptor A-interacting complex 285 kDa protein; peroxisomal proliferator-activated receptor alpha-interacting cofactor complex, 285 kD subunit",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:85441);  (R-HSA-1368108);  (R-HSA-1989781);  (R-HSA-2151201);  (R-HSA-2426168);  (R-HSA-381340);  (R-HSA-400206);  (R-HSA-9707564);  (R-HSA-9707616);  (R-HSA-9931509);  (R-HSA-9933387)",
        "pathway_count": 11,
        "publication_count": 227,
        "publication_id_list": "10.1101/2023.09.13.557529;10075656;10198158;10381560;10400691;10412986;10425206;10494028;10529898;10643692;10713165;10759542;10777541;11018023;11095972;11162494;11226238;11237011;11241162;11267664;11330046;11340167;11387216;11414710;11779144;11809803;11872672;12083769;12118000;12130498;12130638;12177166;12189208;12213831;12356737;12374852;12377782;12406875;12505311;12511571;12563009;12582161;12738229;12745923;12764144;12829629;12969439;1377680;14672706;14980219;15067378;15130092;15175654;15273253;15500444;15560782;15635043;15665827;15684387;15761026;15850785;15919796;16079181;16079853;16239304;16380219;16476485;16503871;16568091;16788062;16857194;16890199;16908542;16911507;16972786;17007889;17011499;17031457;17264172;17306620;17437997;17449569;17715127;17923681;17925399;17980149;18006707;18037887;18215119;18288277;18292238;18343819;18540824;18559965;18587630;18654640;18669648;18680753;18682402;18719978;18726356;18848529;18931025;19001277;19043829;19088433;19115207;19172745;19289416;19356719;19417006;1968462;19690164;19710360;19710929;1971514;19934321;19951946;19968714;20101261;20110263;20138239;20450493;20581824;20719759;20817722;20929863;20937905;21479263;21628546;21889235;22381047;22427940;22446964;22634312;23186163;23239344;23481700;23525231;24129315;24196956;2539258;25645385;26375851;26728094;27071062;2713875;27543614;27600516;27754849;27920218;28111073;28218747;28228285;28698372;28832583;28834231;29242379;29331515;29393594;29508533;29632711;29786170;29789417;2991279;30315122;30779550;31748741;32354867;32695117;3345742;34052659;3427020;3475708;34761308;36639706;37602378;37938771;41446920;6094553;7567999;7592729;7629110;7685352;7732023;7799916;7892212;7909540;7981125;8020941;8060328;8108407;8156598;8325954;8333869;8386511;8402897;8415693;8618898;8619637;8622974;8626466;8626488;8643605;8647822;8663599;8706692;8770873;8798690;8887638;8970730;8976377;9012850;9062340;9065481;9079689;9099716;9144434;9171241;9178750;9286700;9454824;9604010;9634533;9748239;9748295;9836620",
        "class_list": "",
        "function": "Can degrade highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities. Shows a strong preference for pyrimidine over purine residues for its nuclease activity. Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA., [UniProtKB, UniProtKB]; Genetic polymorphisms in PRIC285 gene is associated with autoimmune disease. Publication Status: Online-Only, [RefSeq, PubMed]; HELZ2 promotes K63-linked polyubiquitination of c-Myc to induce retinoblastoma tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]; HELZ2: a new, interferon-regulated, human 3'-5' exoribonuclease of the RNB family is expressed from a non-canonical initiation codon., [RefSeq, PubMed]; Multifunctional nuclear protein involved in RNA surveillance, nuclear receptor-mediated transcriptional regulation, and the restriction of mobile genetic elements as part of the innate immune response (PubMed:37602378). Degrades highly structured RNAs through its concerted ATP-dependent RNA helicase and 3' to 5' exoribonuclease activities (PubMed:37602378). Shows a strong preference for pyrimidine over purine residues for its nuclease activity (PubMed:37602378). Acts as a transcriptional coactivator for a number of nuclear receptors including PPARA, PPARG, THRA, THRB and RXRA (PubMed:16239304, PubMed:23525231). In addition, regulates lipid metabolism independently of PPARs by controlling the stability of Apob mRNA, which encodes a protein essential for lipoprotein assembly and secretion (PubMed:41446920). Also contributes to adipocyte differentiation through interactions with the splicing factor proline- and glutamine-rich protein SFPQ and THRAP3 (PubMed:34052659, PubMed:23525231)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The interferon stimulated gene-encoded protein HELZ2 inhibits human LINE-1 retrotransposition and LINE-1 RNA-mediated type I interferon induction. Erratum:[Nat Commun. 2023 Jan 30;14(1):493. doi: 10.1038/s41467-023-36226-4. PMID: 36717557] Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a nuclear transcriptional co-activator for peroxisome proliferator activated receptor alpha. The encoded protein contains a zinc finger and is a helicase that appears to be part of the peroxisome proliferator activated receptor alpha interacting complex. This gene is a member of the DNA2/NAM7 helicase gene family. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Thrap3 could play indispensable roles in terminal differentiation of adipocytes by enhancing PPARgamma-mediated gene activation cooperatively with Helz2., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 1,
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        "total_reported_n_glycosites": 1,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3C2G2;Q4VXQ1;Q8TEF3;Q96ND3;Q9C094",
        "ec_number_list": [
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                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
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            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
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            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
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            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
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            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
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                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
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                "id": "2.1.1.319",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
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            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
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            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
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            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
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            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
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                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
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        ],
        "go_molecular_function": "GO:0008859 exoribonuclease II activity;GO:0003677 DNA binding;GO:0003713 transcription coactivator activity;GO:0003723 RNA binding;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0043186 P granule",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0035194 regulatory ncRNA-mediated post-transcriptional gene silencing",
        "synthesized_glycan_count": 0,
        "hit_score": 23.0,
        "record_id": "Q9BYK8-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
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                "id": "HEAS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H8Q6",
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            }
        ],
        "mass": 16103.0,
        "length": 139,
        "protein_name": "Putative uncharacterized protein encoded by HEXA-AS1",
        "gene_name": "HEXA-AS1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "HEXA-AS1; C15orf34",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein encoded by HEXA-AS1; HEXA antisense RNA 1; HEXA antisense gene protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
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        "record_id": "Q9H8Q6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9P1Z3-1",
        "uniprot_id": [
            {
                "id": "HCN3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9P1Z3",
                "type": "external"
            }
        ],
        "mass": 86032.0,
        "length": 774,
        "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3",
        "gene_name": "HCN3",
        "organism": "Human",
        "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3",
        "refseq_ac": [
            {
                "id": "NP_065948",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065948",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HCN3; KIAA1535",
        "gene_names_refseq": "HCN3",
        "protein_names_uniprotkb": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3",
        "protein_names_refseq": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 3",
        "tax_id": 9606,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:57657);  (R-HSA-1296061)",
        "pathway_count": 2,
        "publication_count": 15,
        "publication_id_list": "11328811;16043489;16387796;21615589;25987789;28904123;31324691;32157095;32265295;32502341;33298915;35051231;37217939;37733590;38636662",
        "class_list": "",
        "function": "Cryo-EM structure of human HCN3 channel and its regulation by cAMP., [RefSeq, PubMed]; Genetic analysis in 48 Sudden unexpected death in epilepsy cases identified six novel and three previously reported nonsynonymous (amino acid changing) variants in HCN1 , HCN2, HCN3 and HCN4., [RefSeq, PubMed]; Human HCN3 is not modulated by intracellular cAMP, in contrast to other HCN subtypes, [RefSeq, PubMed]; Hyperpolarization-activated cyclic nucleotide-gated cation channel 3 promotes HCC development in a female-biased manner., [RefSeq, PubMed]; Hyperpolarization-activated ion channel that are permeable to sodium and potassium ions, with an about 3:1 preference for potassium ions (PubMed:16043489). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih). In particular, plays a pivotal role in maintaining excitability and promoting rhythmic burst firing within hypothalamic nuclei. Exerts a significant influence on the configuration of the cardiac action potential waveform. Does not appear to play a prominent role in the processing of acute, neuropathic, or inflammatory pain (By similarity)., [UniProtKB, UniProtKB, PubMed]; Reduced HCN3 expression in aganglionic bowel suggests its potential role in Hirschsprung's disease pathophysiology., [RefSeq, PubMed]; This gene encodes a multi-pass membrane protein that functions as a voltage gated cation channel. The encoded protein is a member of a family of closely related cyclic adenosine monophosphate-binding channel proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]., [RefSeq]",
        "predicted_glycosites": 2,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DV90;Q4VX12;Q8N6W6;Q9BWQ2",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0030552 cAMP binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0098855 HCN channel complex",
        "go_biological_process": "GO:0042391 regulation of membrane potential;GO:0071320 cellular response to cAMP;GO:0086091 regulation of heart rate by cardiac conduction;GO:0035725 sodium ion transmembrane transport;GO:0098907 regulation of SA node cell action potential",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q9P1Z3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000011001.001.00000",
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    },
    {
        "uniprot_canonical_ac": "Q9UBI9-1",
        "uniprot_id": [
            {
                "id": "HDC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UBI9",
                "type": "external"
            }
        ],
        "mass": 58837.0,
        "length": 543,
        "protein_name": "Headcase protein homolog",
        "gene_name": "HECA",
        "organism": "Human",
        "refseq_name": "headcase protein homolog",
        "refseq_ac": [
            {
                "id": "NP_057301",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057301",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HECA; HDC",
        "gene_names_refseq": "HDCL; HDC; HECA; HHDC; dJ225E12.1",
        "protein_names_uniprotkb": "Headcase protein homolog; hHDC",
        "protein_names_refseq": "hdc homolog, cell cycle regulator; headcase homolog; headcase protein homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51696)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "11696983;16525680;17081983;18669648;19240061;19643820;19690332;22100912;25576301;26154972;26992070;27862975;28904123;29351928;29393594;29493099;29557506;30429286;31154438;31844290;31848261;32088090;32357974;32938616;32983136;33592498;33912179;33968037;35051231;35580925;35949005;36284347",
        "class_list": "",
        "function": "Data show that HECA may be an early-stage classifier of colorectal cancer that can discriminate between late- and early-stage disease., [RefSeq, PubMed]; Functional analysis of HECA variants identified in congenital heart disease in the Chinese population., [RefSeq, PubMed]; HECA expression is markedly decreased in oral squamous cell carcinoma (OSCC) compared to controls and is associated with decreased sensitivity to cisplatin in OSCC cell lines, [RefSeq, PubMed]; Human HECA slows down cell division of oral squamous cell carcinoma cells and may therefore act as a tumor suppressor in head and neck cancer., [RefSeq, PubMed]; May play an important role in some human cancers. May be part of the regulatory mechanism in the development of epithelial tube networks such as the circulatory system and lungs., [UniProtKB, PubMed]; Mutational and expressional alterations of a candidate tumor suppressor HECA gene in gastric and colorectal cancers., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes the homolog of the Drosophila headcase protein, a highly basic, cytoplasmic protein that regulates the re-entry of imaginal cells into the mitotic cycle during adult morphogenesis. In Drosophila, the encoded protein also inhibits terminal branching of neighboring cells during tracheal development. [provided by RefSeq, Jul 2008]., [RefSeq]",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016020 membrane;GO:0010494 cytoplasmic stress granule",
        "go_biological_process": "GO:0045930 negative regulation of mitotic cell cycle;GO:0034063 stress granule assembly;GO:0030323 respiratory tube development",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q9UBI9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y3Q4-1",
        "uniprot_id": [
            {
                "id": "HCN4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y3Q4",
                "type": "external"
            }
        ],
        "mass": 129042.0,
        "length": 1203,
        "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4",
        "gene_name": "HCN4",
        "organism": "Human",
        "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4",
        "refseq_ac": [
            {
                "id": "NP_005468",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005468",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HCN4",
        "gene_names_refseq": "BRGDA8; EIG18; HCN4; SSS2",
        "protein_names_uniprotkb": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4",
        "protein_names_refseq": "hyperpolarization activated cyclic nucleotide-gated cation channel 4; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 4",
        "tax_id": 9606,
        "disease": "Brugada syndrome 8 (Disease Ontology:DOID:0110225); Gilles de la Tourette syndrome (Disease Ontology:DOID:11119); sick sinus syndrome (Disease Ontology:DOID:13884); generalized epilepsy (Disease Ontology:DOID:1827); epilepsy, idiopathic generalized, susceptibility to, 18 (MONDO:MONDO:0030434)",
        "pathway": " (hsa:10021);  (R-HSA-1296061)",
        "pathway_count": 2,
        "publication_count": 34,
        "publication_id_list": "10228147;10430953;11328811;11675786;12194012;12928435;15123648;16387796;16407510;17977941;19165230;20662977;2071354;20829353;22006928;23103389;24776929;25645385;26546007;28904123;30127718;32157095;32387766;32938616;33298915;33912179;33981976;34509645;35051231;36241641;36244448;37217939;38032931;38432398",
        "class_list": "",
        "function": "A gain-of-function HCN4 mutant in the HCN domain is responsible for inappropriate sinus tachycardia in a Spanish family., [RefSeq, PubMed]; Channel HCN4 mutation R666Q associated with sporadic arrhythmia decreases channel electrophysiological function and increases protein degradation., [RefSeq, PubMed]; Coexistent HCN4 and GATA5 Rare Variants and Atrial Fibrillation in a Large Spanish Family., [RefSeq, PubMed]; HCN4 activates substantially slower than HCN2 and with a half-maximum activation voltage approximately equal 10 mV less negative, both isoforms activate more positively in myocytes suggesting cell-type specificity, [RefSeq, PubMed]; Hyperpolarization-activated ion channel that are permeable to Na(+) and K(+) ions with very slow activation and inactivation (PubMed:10228147, PubMed:10430953, PubMed:20829353). Exhibits higher selectivity for K(+) over Na(+) ions (PubMed:10228147). Contributes to the native pacemaker currents in heart (If) that regulate the rhythm of heart beat (Probable) (PubMed:10228147, PubMed:16407510, PubMed:19165230). Contributes to the native pacemaker currents in neurons (Ih) (Probable). May mediate responses to sour stimuli (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; The rat HCN1 and HCN4 were shown to mediate responses to sour stimuli, suggesting a potential new function for the related human proteins., [RefSeq, PubMed]; This gene encodes a member of the hyperpolarization-activated cyclic nucleotide-gated potassium channels. The encoded protein shows slow kinetics of activation and inactivation, and is necessary for the cardiac pacemaking process. This channel may also mediate responses to sour stimuli. Mutations in this gene have been linked to sick sinus syndrome 2, also known as atrial fibrillation with bradyarrhythmia or familial sinus bradycardia. Two pseudogenes have been identified on chromosome 15. [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 1,
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        "predicted_c_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 4,
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        "reported_snv": 43,
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        "biomarker_type": "",
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        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UMQ7",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005248 voltage-gated sodium channel activity;GO:0005222 intracellularly cAMP-activated cation channel activity;GO:0005249 voltage-gated potassium channel activity;GO:0030552 cAMP binding;GO:0086041 voltage-gated potassium channel activity involved in SA node cell action potential depolarization",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm;GO:0098855 HCN channel complex",
        "go_biological_process": "GO:0006936 muscle contraction;GO:0042391 regulation of membrane potential;GO:0071320 cellular response to cAMP;GO:0008015 blood circulation;GO:0086091 regulation of heart rate by cardiac conduction",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q9Y3Q4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y5Z7-1",
        "uniprot_id": [
            {
                "id": "HCFC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y5Z7",
                "type": "external"
            }
        ],
        "mass": 86779.0,
        "length": 792,
        "protein_name": "Host cell factor 2",
        "gene_name": "HCFC2",
        "organism": "Human",
        "refseq_name": "host cell factor 2",
        "refseq_ac": [
            {
                "id": "NP_037452",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037452",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HCFC2",
        "gene_names_refseq": "HCF-2; HCF2; HCFC2",
        "protein_names_uniprotkb": "Host cell factor 2; C2 factor; HCF-2",
        "protein_names_refseq": "C2 factor; host cell factor 2",
        "tax_id": 9606,
        "disease": "congenital heart disease (Disease Ontology:DOID:1682)",
        "pathway": " (hsa:29915);  (R-HSA-9772755)",
        "pathway_count": 2,
        "publication_count": 108,
        "publication_id_list": "10196288;11237011;12393701;12482972;12670868;14636557;14992727;15199122;16227571;16239140;16829959;16878130;16892064;17355966;17500065;17612494;17671196;17925232;17998332;18598942;18829457;18829459;18838386;18838538;19103755;19124460;19187761;19556245;20018852;20068231;20575550;20716525;20961854;21106533;21124902;21131905;21135039;21220120;22266653;22327296;22652693;22665483;23481700;23508102;23995757;24244196;24368734;24680668;24715725;25561738;25576301;25593305;25892735;26154972;26324722;26886794;26992070;27563068;27698142;27760318;27862975;28182322;28398509;28832583;28834231;28904123;29138278;29242379;29493099;29508533;29557506;29632711;29769354;29786170;29897600;29937342;30429286;31049581;31400120;31485071;31492838;31544921;31844290;32157095;32488085;32983136;33298915;33592498;33657400;33912179;34012049;34019948;34171305;34932366;34933446;35033534;35051231;35132862;35190547;35439434;35580925;36010968;36284347;37217939;37938771;38665916;39531497;40596516",
        "class_list": "",
        "function": "HCF-2 is broadly present in human and mouse cells, and possesses activities distinct from HCF-1, [RefSeq, PubMed]; This gene encodes one of two proteins which interact with VP16, a herpes simplex virus protein that initiates virus infection. Both the encoded protein and the original Herpes host cell factor interact with VP16 through a beta-propeller domain. The original Herpes host cell factor, however, is effective at initiating viral infection while the encoded protein is not. Transcripts of varying length due to alternative polyadenylation signals have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
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        "reported_fully_resolved_glycans": 1,
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        "reported_mutagensis": 0,
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        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8Q5;C0H5X3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003713 transcription coactivator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0035097 histone methyltransferase complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016032 viral process;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 11.2,
        "record_id": "Q9Y5Z7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NHT5-1",
        "uniprot_id": [
            {
                "id": "HMX3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NHT5",
                "type": "external"
            }
        ],
        "mass": 37825.0,
        "length": 357,
        "protein_name": "Homeobox protein HMX3",
        "gene_name": "HMX3",
        "organism": "Human",
        "refseq_name": "homeobox protein HMX3",
        "refseq_ac": [
            {
                "id": "NP_001099044",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099044",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HMX3; NKX-5.1; NKX5-1",
        "gene_names_refseq": "HMX3; NKX-5.1; NKX5.1; Nkx5-1",
        "protein_names_uniprotkb": "Homeobox protein HMX3; Homeobox protein H6 family member 3; Homeobox protein Nkx-5.1",
        "protein_names_refseq": "homeo box (H6 family) 3; homeobox (H6 family) 3; homeobox protein H6 family member 3; homeobox protein HMX3; homeobox protein Nkx-5.1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:340784)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "19253379;22779713;23186163;23481700;24366607;24715725;25892735;27846572;27920218;28228285;28832583;28855257;28904123;29242379;29557506;29769354;30315122;31217245;31530632;31844290;32357974;32387766;33048949;33298915;33392160;33912179;34932366;35051231;35132862;36204976;36241641;39531497;39534244",
        "class_list": "",
        "function": "Aberrant expression of NKL homeobox genes HMX2 and HMX3 interferes with cell differentiation in acute myeloid leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; One sequence alteration, heterozygous c.114C->T (conservative change without alteration of amino acid) in exon 1 of HMX3, was detected in 2 of 15 patients with superior semicircular dehiscence syndrome., [RefSeq, PubMed]; Propose that hemizygous deletions of HMX2 and HMX3 are responsible for inner ear malformations, vestibular dysfunction, and congenital sensorineural hearing loss, [RefSeq, PubMed]; Transcription factor involved in specification of neuronal cell types and which is required for inner ear and hypothalamus development. Binds to the 5'-CAAGTG-3' core sequence. Controls semicircular canal formation in the inner ear. Also required for hypothalamic/pituitary axis of the CNS (By similarity)., [UniProtKB]; USP38 inhibits colorectal cancer cell proliferation and migration via downregulating HMX3 ubiquitylation., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MU06",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007399 nervous system development;GO:0030154 cell differentiation;GO:0043583 ear development",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "A6NHT5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "B7ZW38-1",
        "uniprot_id": [
            {
                "id": "HNRC3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/B7ZW38",
                "type": "external"
            }
        ],
        "mass": 32029.0,
        "length": 293,
        "protein_name": "Heterogeneous nuclear ribonucleoprotein C-like 3",
        "gene_name": "HNRNPCL3",
        "organism": "Human",
        "refseq_name": "heterogeneous nuclear ribonucleoprotein C-like 4",
        "refseq_ac": [
            {
                "id": "NP_001289480",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289480",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HNRNPCL3",
        "gene_names_refseq": "HNRNPCL4",
        "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein C-like 3",
        "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein C-like 4",
        "tax_id": 9606,
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        "pathway": " (hsa:101060301);  (hsa:649330)",
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        "go_molecular_function": "GO:0003723 RNA binding",
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        "record_id": "B7ZW38-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "C9JL84-1",
        "uniprot_id": [
            {
                "id": "HHLA1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/C9JL84",
                "type": "external"
            }
        ],
        "mass": 58297.0,
        "length": 531,
        "protein_name": "HERV-H LTR-associating protein 1",
        "gene_name": "HHLA1",
        "organism": "Human",
        "refseq_name": "HERV-H LTR-associating protein 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001138567",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138567",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HHLA1",
        "gene_names_refseq": "HHLA1; PLA2L",
        "protein_names_uniprotkb": "HERV-H LTR-associating protein 1",
        "protein_names_refseq": "HERV-H LTR-associating 1; HERV-H LTR-associating protein 1 precursor; HERV-H LTR-associating protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10086)",
        "pathway_count": 1,
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        "publication_id_list": "10329003;11237011;31324691;32938616;34171305;35051231;8382789",
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        "predicted_glycosites": 3,
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        "go_cellular_component": "GO:0005576 extracellular region",
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        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "C9JL84-1",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P01893-1",
        "uniprot_id": [
            {
                "id": "HLAH_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P01893",
                "type": "external"
            }
        ],
        "mass": 40892.0,
        "length": 362,
        "protein_name": "Putative HLA class I histocompatibility antigen, alpha chain H",
        "gene_name": "HLA-H",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "HLA-H; HLAH",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative HLA class I histocompatibility antigen, alpha chain H; HLA-12.4; HLA-AR; MHC class I antigen H",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "graft-versus-host disease (Disease Ontology:DOID:0081267); myositis (Disease Ontology:DOID:633)",
        "pathway": " (R-HSA-1236974);  (R-HSA-1236977);  (R-HSA-198933);  (R-HSA-6798695);  (R-HSA-877300);  (R-HSA-909733);  (R-HSA-9705671);  (R-HSA-983170)",
        "pathway_count": 8,
        "publication_count": 306,
        "publication_id_list": "10064069;10067896;10395669;10468607;10499918;10542297;10600378;10746781;10777614;10825291;10982397;10982844;10986460;11092454;11160214;11163199;11247303;11265639;11337497;11377645;11404376;11489943;11513152;11514579;11556966;11585831;11807247;11857637;11858820;11861603;11955593;11955595;11955599;11972023;12019269;12029096;12040185;12213321;12436109;12436110;12438563;12446674;12483297;12588680;12645939;12692549;12759408;12766484;12842042;12915721;1396683;14586410;14681859;14718384;14719373;14722222;14769151;14970179;15034010;15047845;1508672;15136729;15143187;15155468;15187158;15208624;15286279;15304001;15312780;15322115;15388922;15449939;15530433;15534202;15541655;15580655;15607800;15778442;15778510;15781451;15800062;15851719;15864273;15927284;16009940;16014749;16091383;16129954;16171819;16237089;16339513;16380601;16465444;16467876;16473882;16551255;16737824;16754721;16893496;16904340;16928187;16987978;17045824;17056546;17057721;17088086;17125875;17237375;17251292;1730654;17316621;17337780;17351669;17656363;17969444;18031695;18035202;18037897;18055229;18209062;18234675;18268517;18362138;18575461;18591661;18593354;18692471;18802471;19119025;19149696;19193869;19217269;19261456;19342655;19359216;19361863;19426129;19498108;19575639;19592130;19851281;19918052;20049711;20130243;20304997;20363976;2038058;20605430;20643137;20730098;21050182;21241660;21800138;21841309;21877119;2211721;22153078;22396535;22941947;23061660;23121362;23613522;23650620;23695528;23929856;24305946;24417533;2450918;25083866;25371710;25703557;25716998;26284469;26300885;29557506;29786170;30485383;31844290;31850239;32032529;32113509;32350084;32353859;32357974;32387766;32428392;32488085;32502341;32511913;32561536;32574262;32589897;32661006;32726803;32728199;32758689;32862111;32953130;32979938;33024073;33060197;33097660;33110251;33117408;33189161;33193462;33239784;33349665;33360543;33372174;33372854;33396578;33396605;33440148;33479219;33495715;33514628;33567255;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33936100;33963333;33989516;33990585;34019948;34021074;34054808;34078123;34084167;34110168;34166398;34185709;34239064;34290717;34341353;34357683;34375313;34400613;34439781;34452305;34471099;34502139;34597346;35051231;35102342;35643212;36215666;36284347;37051252;37217939;40914422;6162102;6461010;6548414;688397;7510216;7514165;7526154;7530745;7531291;7537377;7540766;7542404;7615558;7617032;7642652;7657660;7673114;7690989;7796299;7876241;8156998;8176225;8178173;8197134;8232552;8342042;8483949;8530158;8550631;8605876;8621447;8631301;8692836;8702790;8995416;9096384;9111318;9121453;9143706;9242679;9285412;9314561;9334213;9605141;9660177;9700512;9730896;9847332;9861020",
        "class_list": "",
        "function": "Involved in the presentation of foreign antigens to the immune system., [UniProtKB]",
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        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0030881 beta-2-microglobulin binding;GO:0042605 peptide antigen binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0002476 antigen processing and presentation of endogenous peptide antigen via MHC class Ib;GO:0006955 immune response;GO:0002486 antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independent;GO:0001916 positive regulation of T cell mediated cytotoxicity",
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    },
    {
        "uniprot_canonical_ac": "P50135-1",
        "uniprot_id": [
            {
                "id": "HNMT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P50135",
                "type": "external"
            }
        ],
        "mass": 33295.0,
        "length": 292,
        "protein_name": "Histamine N-methyltransferase",
        "gene_name": "HNMT",
        "organism": "Human",
        "refseq_name": "histamine N-methyltransferase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001019245",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019245",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HNMT",
        "gene_names_refseq": "HMT; HNMT-S1; HNMT-S2; HNMT; MRT51",
        "protein_names_uniprotkb": "Histamine N-methyltransferase; 2.1.1.8; HMT",
        "protein_names_refseq": "histamine N-methyltransferase isoform 2",
        "tax_id": 9606,
        "disease": "autosomal recessive intellectual developmental disorder 51 (Disease Ontology:DOID:0081214); Pick's disease (Disease Ontology:DOID:11870); Huntington's disease (Disease Ontology:DOID:12858); Down syndrome (Disease Ontology:DOID:14250); Parkinson's disease (Disease Ontology:DOID:14330); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); brain infarction (Disease Ontology:DOID:3454); rhinitis (Disease Ontology:DOID:4483); essential tremor (Disease Ontology:DOID:4990); schizophrenia (Disease Ontology:DOID:5419); ulcerative colitis (Disease Ontology:DOID:8577)",
        "pathway": " (hsa:3176);  (R-HSA-2408508);  (R-HSA-70921)",
        "pathway_count": 3,
        "publication_count": 44,
        "publication_id_list": "10773664;10803682;11566133;11578145;12072962;12815595;1425659;14667820;1483038;15221005;15806399;16037612;16444005;1711890;17451884;18154359;19304569;20097752;20164179;20383543;2339986;26001783;26206890;29506638;29557506;29564728;30429286;30779550;31848261;32157095;33392160;34185709;34680041;35051231;35163585;35580925;36378841;6456763;7305945;7901203;7943261;8145732;8605025;9547362",
        "class_list": "",
        "function": "HNMT Upregulation Induces Cancer Stem Cell Formation and Confers Protection against Oxidative Stress through Interaction with HER2 in Non-Small-Cell Lung Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine., [UniProtKB, PubMed]; Inhibition of Astrocytic Histamine N-Methyltransferase as a Possible Target for the Treatment of Alzheimer's Disease. Review article Publication Status: Online-Only, [RefSeq, PubMed]; MiR-223 participates in the pathogenesis of atopic dermatitis through upregulating HNMT indirectly to degrade the excessive histamine. Publication Status: Online-Only, [RefSeq, PubMed]; NHMT polymorphisms are not associated with Parkinson's disease, ALS and multiple system atrophy in Chinese population., [RefSeq, PubMed]; The Thr105Ile Variant (rs11558538) of the Histamine N-methyltransferase Gene may be associated with Reduced Risk of Parkinson Disease: A Meta-analysis., [RefSeq, PubMed]",
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        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 12,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9J3;Q546Z6;Q7Z7I2;Q8IU56;Q8WW98;Q9BRW6",
        "ec_number_list": [
            {
                "id": "2.1.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.1",
                "type": "external"
            },
            {
                "id": "2.1.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.8",
                "type": "external"
            },
            {
                "id": "2.1.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.20",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046539 histamine N-methyltransferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0007585 respiratory gaseous exchange by respiratory system;GO:0032259 methylation;GO:0006548 L-histidine catabolic process;GO:0001695 histamine catabolic process;GO:0001692 histamine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "P50135-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P60008-1",
        "uniprot_id": [
            {
                "id": "HILS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P60008",
                "type": "external"
            }
        ],
        "mass": 25632.0,
        "length": 231,
        "protein_name": "Putative histone H1.9",
        "gene_name": "H1-9P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "H1-9P; H1-9; HILS1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative histone H1.9; H1.9 linker histone pseudogene; Putative spermatid-specific linker histone H1-like protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "12920187",
        "class_list": "",
        "function": "DNA-binding protein that may be implicated in chromatin remodeling and/or transcriptional regulation during spermiogenesis, the process of spermatid maturation into spermatozoa., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003676 nucleic acid binding;GO:0003690 double-stranded DNA binding;GO:0042393 histone binding;GO:0031492 nucleosomal DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0001673 male germ cell nucleus;GO:0000786 nucleosome",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0006355 regulation of DNA-templated transcription;GO:0006334 nucleosome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "P60008-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P78552-1",
        "uniprot_id": [
            {
                "id": "I13R1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P78552",
                "type": "external"
            }
        ],
        "mass": 48760.0,
        "length": 427,
        "protein_name": "Interleukin-13 receptor subunit alpha-1",
        "gene_name": "IL13RA1",
        "organism": "Human",
        "refseq_name": "interleukin-13 receptor subunit alpha-1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001551",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001551",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL13RA1; IL13RA; IL13R",
        "gene_names_refseq": "CD213A1; CT19; IL-13Ra; IL13RA1; NR4",
        "protein_names_uniprotkb": "Interleukin-13 receptor subunit alpha-1; CT19; Cancer/testis antigen 19; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL-13R-alpha-1; IL-13RA1",
        "protein_names_refseq": "CD213a1 antigen; IL-13 receptor subunit alpha-1; IL-13R subunit alpha-1; IL13 receptor alpha-1 chain; cancer/testis antigen 19; interleukin 13 receptor, alpha 1; interleukin-13 receptor subunit alpha-1 precursor",
        "tax_id": 9606,
        "disease": "asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); systemic scleroderma (Disease Ontology:DOID:418); pulmonary hypertension (Disease Ontology:DOID:6432); psoriasis (Disease Ontology:DOID:8893)",
        "pathway": " (hsa:3597);  (R-HSA-6785807)",
        "pathway_count": 2,
        "publication_count": 120,
        "publication_id_list": "10.1101/2023.09.13.557529;10023775;10219247;10369418;10510379;10586089;10791955;10867011;11058569;11084045;11104795;11120780;11237011;11278437;11278729;11356008;11404481;11463377;11960372;12223527;12242343;12600988;12832402;14634100;14712222;15116091;15261459;15584925;15805299;15869882;15950906;16007214;16048438;16107692;16205632;16236134;16397018;16451196;16510571;16540365;16606674;17427945;17458857;17572495;18243101;18353781;18447642;18644974;19124156;19185846;19397496;20493732;21102457;21252155;21689689;21730069;21937440;21994466;22046235;22205702;22383755;22693070;22851691;23086340;23124025;23172665;23455323;23555662;23967200;24097101;24743777;25234944;25502872;27600516;27862975;29242379;29557506;29671580;30107911;30429286;31844290;32157095;32350084;32502341;32983136;33123756;33592498;33638296;33912179;33936100;33968037;33981976;34357683;35051231;35251023;35409019;35580925;36284347;38609001;7510216;7512451;7529288;7795521;7796300;7898939;7907877;8085155;8602263;8621622;8663118;8668165;8797861;8816495;8910586;9013879;9651359;9723655;9736340;9822675;9874564",
        "class_list": "",
        "function": "Binds with low affinity to interleukin-13 (IL13). Together with IL4RA can form a functional receptor for IL13. Also serves as an alternate accessory protein to the common cytokine receptor gamma chain for interleukin-4 (IL4) signaling, but cannot replace the function of IL2RG in allowing enhanced interleukin-2 (IL2) binding activity., [UniProtKB, UniProtKB, UniProtKB]; IL-13 and IL-13Ralpha1 are overexpressed in extranodal natural killer/T cell lymphoma and mediate tumor cell proliferation., [RefSeq, PubMed]; Identification of serum interleukin-13 and interleukin-13 receptor subunit expressions: Rheumatoid arthritis-associated interstitial lung disease., [RefSeq, PubMed]; Loss of Interleukin-13-Receptor-Alpha-1 Induces Apoptosis and Promotes EMT in Pancreatic Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; MEF2D facilitates liver metastasis of gastric cancer cells through directly inducing H1X under IL-13 stimulation., [RefSeq, PubMed]; The protein encoded by this gene is a subunit of the interleukin 13 receptor. This subunit forms a receptor complex with IL4 receptor alpha, a subunit shared by IL13 and IL4 receptors. This subunit serves as a primary IL13-binding subunit of the IL13 receptor, and may also be a component of IL4 receptors. This protein has been shown to bind tyrosine kinase TYK2, and thus may mediate the signaling processes that lead to the activation of JAK1, STAT3 and STAT6 induced by IL13 and IL4. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 8818,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 6,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95646;Q5JSL4;Q99656;Q9UDY5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019955 cytokine binding;GO:0004896 cytokine receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane;GO:0005898 interleukin-13 receptor complex;GO:0016020 membrane",
        "go_biological_process": "GO:0035771 interleukin-4-mediated signaling pathway;GO:0007166 cell surface receptor signaling pathway;GO:0042531 positive regulation of tyrosine phosphorylation of STAT protein;GO:0019221 cytokine-mediated signaling pathway;GO:0035772 interleukin-13-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 13.2,
        "record_id": "P78552-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14541-1",
        "uniprot_id": [
            {
                "id": "HNF4G_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14541",
                "type": "external"
            }
        ],
        "mass": 45877.0,
        "length": 408,
        "protein_name": "Hepatocyte nuclear factor 4-gamma",
        "gene_name": "HNF4G",
        "organism": "Human",
        "refseq_name": "hepatocyte nuclear factor 4-gamma isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001317490",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317490",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HNF4G; NR2A2",
        "gene_names_refseq": "HNF4G; NR2A2; NR2A3",
        "protein_names_uniprotkb": "Hepatocyte nuclear factor 4-gamma; HNF-4-gamma; Nuclear receptor subfamily 2 group A member 2",
        "protein_names_refseq": "HNF-4-gamma; hepatocyte nuclear factor 4-gamma isoform 2; nuclear receptor subfamily 2 group A member 2",
        "tax_id": 9606,
        "disease": "maturity-onset diabetes of the young (Disease Ontology:DOID:0050524); maturity-onset diabetes of the young type 1 (Disease Ontology:DOID:0111099); Fanconi syndrome (Disease Ontology:DOID:1062); alcohol use disorder (Disease Ontology:DOID:1574); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:3174);  (R-HSA-210745);  (R-HSA-383280)",
        "pathway_count": 3,
        "publication_count": 30,
        "publication_id_list": "10235266;10512380;10542397;11237011;11865025;12220494;12544512;15175151;15896744;16751179;24366607;25589627;29557506;31844290;32157095;32387766;32737864;33537174;33592498;33758932;33912179;33968037;34509645;34794218;34965388;35580925;36241641;36607591;8622695;9653119",
        "class_list": "",
        "function": "2.7 A X-ray crystalography results suggest that the HNF4s may be transcription factors that are constitutively bound to fatty acids, [RefSeq, PubMed]; HNF4G stimulates the development of pancreatic cancer by promoting IGF2BP2 transcription., [RefSeq, PubMed]; Hepatocyte nuclear factor 4 gamma (HNF4G) is correlated with poor prognosis and promotes tumor cell growth by inhibiting caspase-dependent intrinsic apoptosis in colorectal cancer., [RefSeq, PubMed]; Metformin inhibits pancreatic cancer metastasis caused by SMAD4 deficiency and consequent HNF4G upregulation., [RefSeq, PubMed]; MicroRNA-320b suppresses HNF4G and IGF2BP2 expression to inhibit angiogenesis and tumor growth of lung cancer., [RefSeq, PubMed]; Results suggest that the expression level of dihydrodiol dehydrogenase 4 mRNA is cooperatively regulated by the amounts of HNF-1 alpha, HNF-4 alpha and HNF-4 gamma, [RefSeq, PubMed]; Transcription factor. Has a lower transcription activation potential than HNF4-alpha., [UniProtKB]; [Expression of hepatocyte nuclear factor 4gamma in gastric carcinoma and its role in cell proliferation and stemness]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z2V9;Q9UH81;Q9UIS6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0004879 nuclear receptor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q14541-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q1KMD3-1",
        "uniprot_id": [
            {
                "id": "HNRL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q1KMD3",
                "type": "external"
            }
        ],
        "mass": 85105.0,
        "length": 747,
        "protein_name": "Heterogeneous nuclear ribonucleoprotein U-like protein 2",
        "gene_name": "HNRNPUL2",
        "organism": "Human",
        "refseq_name": "heterogeneous nuclear ribonucleoprotein U-like protein 2",
        "refseq_ac": [
            {
                "id": "NP_001073027",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073027",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HNRNPUL2; HNRPUL2",
        "gene_names_refseq": "HNRNPUL2; HNRPUL2; SAF-A2",
        "protein_names_uniprotkb": "Heterogeneous nuclear ribonucleoprotein U-like protein 2; SAF-A2; Scaffold-attachment factor A2",
        "protein_names_refseq": "heterogeneous nuclear ribonucleoprotein U-like protein 2; scaffold-attachment factor A2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:221092)",
        "pathway_count": 1,
        "publication_count": 81,
        "publication_id_list": "16964243;18212344;18452278;18510355;18566446;18669648;18691976;18707149;19007248;19117535;19413330;19651622;19664994;20058876;20068231;20112406;20166139;21872626;22365830;22544926;23301498;23576270;24129315;24714562;24715725;26154972;26992070;27397612;27846572;27862975;28510447;28594403;28904123;29351928;29437277;29493099;29557506;30379171;30410026;30429286;30484775;31844290;32157095;32387766;32488085;32502341;32938616;32983136;33043033;33141586;33214551;33298915;33392160;33465208;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34405274;34509645;34561969;34725712;35051231;35318648;35580925;36010968;36215666;36241641;36284347;37938771;38665916;40596516;40914422",
        "class_list": "",
        "function": "HnRNPUL1 and -2 function downstream of MRN and CtBP-interacting protein (CtIP) to promote recruitment of the BLM helicase to DNA breaks., [RefSeq, PubMed]; It was demonstrated that CRNDE could form a functional complex with heterogeneous nuclear ribonucleoprotein U-like 2 protein (hnRNPUL2) and direct the transport of hnRNPUL2 between the nucleus and cytoplasm. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N3B3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016020 membrane;GO:0045202 synapse",
        "go_biological_process": "GO:0000380 alternative mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 8.7,
        "record_id": "Q1KMD3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5VY09-1",
        "uniprot_id": [
            {
                "id": "IER5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5VY09",
                "type": "external"
            }
        ],
        "mass": 33704.0,
        "length": 327,
        "protein_name": "Immediate early response gene 5 protein",
        "gene_name": "IER5",
        "organism": "Human",
        "refseq_name": "immediate early response gene 5 protein",
        "refseq_ac": [
            {
                "id": "NP_057629",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057629",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IER5; PP4583; SBBI48",
        "gene_names_refseq": "IER5; SBBI48",
        "protein_names_uniprotkb": "Immediate early response gene 5 protein",
        "protein_names_refseq": "immediate early response gene 5 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51278)",
        "pathway_count": 1,
        "publication_count": 68,
        "publication_id_list": "11102586;15498874;19238419;21993680;22132193;23481700;24714562;24715725;25355627;25576301;25645385;25816751;26154972;26375851;26496226;26728094;26754925;26992070;27397612;27600516;27846572;28228285;28446606;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632711;29786170;30315122;30429286;30524438;30599213;30779550;30833945;31669744;31844290;31848261;31998317;32161166;32471508;32488085;32502341;32897882;32936072;32938616;32983136;33141586;33298915;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34932366;35051231;35561310;35580925;36047562;36284347",
        "class_list": "",
        "function": "IER5, a DNA damage response gene, is required for Notch-mediated induction of squamous cell differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; Novel role of PAF1 in attenuating radiosensitivity in cervical cancer by inhibiting IER5 transcription. Publication Status: Online-Only, [RefSeq, PubMed]; Nuclear localization signal at amino acids 217-244 mediates complex formation with importin-alpha and importin-beta. NLS is essential for HSF1 dephosphorylation and full activation by IER5., [RefSeq, PubMed]; PP2A-B55 and its adapter proteins IER2 and IER5 regulate the activity of RB family proteins and the expression of cell cycle-related genes., [RefSeq, PubMed]; Plays a role as a transcription factor (PubMed:22132193, PubMed:25355627). Mediates positive transcriptional regulation of several chaperone genes during the heat shock response in a HSF1-dependent manner (PubMed:25355627, PubMed:25816751). Mediates negative transcriptional regulation of CDC25B expression (PubMed:22132193). Plays a role in the dephosphorylation of the heat shock factor HSF1 and ribosomal protein S6 kinase (S6K) by the protein phosphatase PP2A (PubMed:25816751, PubMed:26496226). Involved in the regulation of cell proliferation and resistance to thermal stress (PubMed:22132193, PubMed:25355627, PubMed:26496226). Involved in the cell cycle checkpoint and survival in response to ionizing radiation (PubMed:19238419, PubMed:22132193). Associates with chromatin to the CDC25B promoter (PubMed:22132193)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Studies in rat found higher mRNA levels after waking and sleep deprivation for immediate early genes/transcription factors such as IER5, [RefSeq, PubMed]; The early radiation-induced expression of IER5 affects radiosensitivity via disturbing radiation-induced cell cycle checkpoints, [RefSeq, PubMed]; The results suggest that IER2, IER5, and IER5L proteins are target protein-specific regulators of PP2A (protein phosphatase 2A) activity and modulate cell proliferation through CDC25A (cell division cycle 25A protein) activity., [RefSeq, PubMed]; This gene encodes a protein that is similar to other immediate early response proteins. In the mouse, a similar gene may play an important role in mediating the cellular response to mitogenic signals. Studies in rats found the expression of a similar gene to be increased after waking and sleep deprivation. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional repression mediated by IER5 regulates Cdc25B expression levels via the release of NF-YB and p300 in acute myeloid leukemia., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBV3;Q8WY68;Q9NY49;Q9NZP9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0042127 regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034605 cellular response to heat;GO:1900036 positive regulation of cellular response to heat",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "Q5VY09-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZVW7-1",
        "uniprot_id": [
            {
                "id": "I17EL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZVW7",
                "type": "external"
            }
        ],
        "mass": 56555.0,
        "length": 507,
        "protein_name": "Interleukin-17 receptor E-like protein",
        "gene_name": "IL17REL",
        "organism": "Human",
        "refseq_name": "interleukin-17 receptor E-like protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001001694",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001694",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL17REL",
        "gene_names_refseq": "IL17REL",
        "protein_names_uniprotkb": "Interleukin-17 receptor E-like protein; IL-17 receptor E-like; IL-17RE-like",
        "protein_names_refseq": "IL-17 receptor E-like; IL-17RE-like; interleukin-17 receptor E-like protein isoform 1; interleukin-17 receptor E-like protein; putative interleukin-17 receptor E-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:400935)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;18477386;20228798;26480299;28063628;28218747;28405828;29393594;29632046;31154438",
        "class_list": "",
        "function": "Rare Il17REL Variants are associated with Familial and Sporadic Inflammatory Bowel Disease., [RefSeq, PubMed]; The high copy number variant in the ABCF1 gene was the strongest risk factor for gout (OR = 5.70), while a low copy number variant in the IL17REL gene was the strongest protective factor against gout (OR = 0.15), [RefSeq, PubMed]; We performed a genome-wide association analysis of ulcerative colitis and discovered new associations in il17rel GeneRIF: Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "predicted_o_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
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        "total_reported_c_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "A0A8Q3WKV1;A6NCN4;A6PVC1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030368 interleukin-17 receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q6ZVW7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z5L9-1",
        "uniprot_id": [
            {
                "id": "I2BP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z5L9",
                "type": "external"
            }
        ],
        "mass": 61025.0,
        "length": 587,
        "protein_name": "Interferon regulatory factor 2-binding protein 2",
        "gene_name": "IRF2BP2",
        "organism": "Human",
        "refseq_name": "interferon regulatory factor 2-binding protein 2 isoform B",
        "refseq_ac": [
            {
                "id": "NP_001070865",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070865",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IRF2BP2",
        "gene_names_refseq": "CVID14; IRF2BP2; LRIR2",
        "protein_names_uniprotkb": "Interferon regulatory factor 2-binding protein 2; IRF-2-binding protein 2; IRF-2BP2",
        "protein_names_refseq": "IRF-2-binding protein 2; interferon regulatory factor 2-binding protein 2 isoform B",
        "tax_id": 9606,
        "disease": "common variable immunodeficiency 14 (Disease Ontology:DOID:0081156); neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures (Disease Ontology:DOID:0081327); central nervous system disease (Disease Ontology:DOID:331)",
        "pathway": " (hsa:359948)",
        "pathway_count": 1,
        "publication_count": 104,
        "publication_id_list": "12799427;15302935;17081983;17924679;18212344;18220336;18452278;18669648;18707149;19190336;19413330;19415658;19651622;19664995;19690332;20058876;20068231;20166139;20702774;21406692;21576369;21887377;22645359;23186163;24275569;24714562;24715725;25260593;25576301;25755297;26154972;26992070;27016798;27846572;28510447;28904123;29237092;29351928;29493099;29557506;30059200;30379171;30410026;30429286;30620550;31217245;31373491;31492838;31844290;32119511;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32938750;32983136;33043033;33141586;33214551;33298915;33392160;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34019948;34171305;34211107;34509645;34561969;35051231;35132862;35251023;35254053;35318648;35513511;35561310;35580925;35705054;36002076;36010968;36215666;36284347;36448218;37340703;37541260;37876937;37938771;38665916;38838015;38864832;39059757;39302247;39531497;39534244;40307207;40596516",
        "class_list": "",
        "function": "A novel IRF2BP2::CDX2 Gene fusion in digital intravascular myoepithelioma of soft tissue: An enigma!, [RefSeq, PubMed]; Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities (PubMed:12799427). Represses the NFAT1-dependent transactivation of NFAT-responsive promoters (PubMed:21576369). Acts as a coactivator of VEGFA expression in cardiac and skeletal muscles (PubMed:20702774). Plays a role in immature B-cell differentiation (PubMed:27016798)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Identification of IRF-2 binding protein 1 and IRF-2 binding protein 2 as co-repressor molecules for interferon regulatory factor-2., [RefSeq, PubMed]; LncRNA ATP1A1-AS1 inhibits cell proliferation and promotes cell apoptosis in thyroid carcinoma by regulating the miR-620/IRF2BP2 axis., [RefSeq, PubMed]; Novel frameshift variants expand the map of the genetic defects in IRF2BP2. Publication Status: Online-Only, [RefSeq, PubMed]; Novel hypermorphic variants in IRF2BP2 identified in patients with common variable immunodeficiency and autoimmunity., [RefSeq, PubMed]; Results indicate that DIF-1 plays a key role in breast cancer cell survival, [RefSeq, PubMed]; Super-enhancer-driven IRF2BP2 enhances ALK activity and promotes neuroblastoma cell proliferation., [RefSeq, PubMed]; This gene encodes an interferon regulatory factor-2 (IRF2) binding protein that interacts with the C-terminal transcriptional repression domain of IRF2. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 19,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 19,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 19,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 22,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 43,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 20,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1AM35;B1AM36;Q6P083;Q7Z5L8;Q8N351;Q8WUH8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0002327 immature B cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "Q7Z5L9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IU81-1",
        "uniprot_id": [
            {
                "id": "I2BP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IU81",
                "type": "external"
            }
        ],
        "mass": 61688.0,
        "length": 584,
        "protein_name": "Interferon regulatory factor 2-binding protein 1",
        "gene_name": "IRF2BP1",
        "organism": "Human",
        "refseq_name": "interferon regulatory factor 2-binding protein 1",
        "refseq_ac": [
            {
                "id": "NP_056464",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056464",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IRF2BP1",
        "gene_names_refseq": "IRF2BP1",
        "protein_names_uniprotkb": "Interferon regulatory factor 2-binding protein 1; 2.3.2.27; IRF-2-binding protein 1; IRF-2BP1; Probable E3 ubiquitin-protein ligase IRF2BP1; Probable RING-type E3 ubiquitin transferase IRF2BP1",
        "protein_names_refseq": "IRF-2-binding protein 1; interferon regulatory factor 2-binding protein 1; probable E3 ubiquitin-protein ligase IRF2BP1; probable RING-type E3 ubiquitin transferase IRF2BP1",
        "tax_id": 9606,
        "disease": "neurodevelopmental disorder with regression, abnormal movements, loss of speech, and seizures (Disease Ontology:DOID:0081327); central nervous system disease (Disease Ontology:DOID:331)",
        "pathway": " (hsa:26145)",
        "pathway_count": 1,
        "publication_count": 78,
        "publication_id_list": "12799427;17081983;18212344;18220336;18452278;18511908;18669648;18671972;19651622;19664995;19690332;20068231;20112406;21406692;23186163;23301498;24129315;24275569;24715725;25418920;25576301;25645385;25810538;25880248;26154972;26375851;26811146;26929215;26992070;27862975;27920218;28063628;28228285;28514659;28832583;28834231;28904123;29242379;29351928;29393594;29493099;29557506;29632046;29786170;30059200;30315122;30379171;30429286;30524438;30833945;31154438;31217245;31530632;31844290;31848261;32157095;32265295;32574038;32938616;32983136;33141586;33298915;33480129;33592498;33912179;33936100;33968037;33981976;34171305;34211107;34725712;35051231;35132862;35154160;35513511;35580925;36284347;38838015",
        "class_list": "",
        "function": "Acts as a transcriptional corepressor in a IRF2-dependent manner; this repression is not mediated by histone deacetylase activities. May act as an E3 ligase towards JDP2, enhancing its polyubiquitination. Represses ATF2-dependent transcriptional activation., [UniProtKB, PubMed, PubMed]; IRF2-BP1 is a JDP2-binding protein enhancing the polyubiquitination of JDP2 and represses ATF2-mediated transcriptional activation from a CRE-containing promoter., [RefSeq, PubMed]; Identification of IRF-2 binding protein 1 and IRF-2 binding protein 2 as co-repressor molecules for interferon regulatory factor-2., [RefSeq, PubMed]; PCTA (IRF2BP1) defines a new component of the TGF-beta signalling pathway that functions to facilitate Smad2 phosphorylation through controlling the accumulation of cPML into the cytoplasm, and consequently, the assembly of Smad2-receptor complex., [RefSeq, PubMed]; Transient deSUMOylation of IRF2BP proteins controls early transcription in EGFR signaling., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
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        "predicted_o_glycosites": 2,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53EL7;Q6DC95;Q9BRZ9;Q9Y4P4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0000209 protein polyubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "Q8IU81-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BW71-1",
        "uniprot_id": [
            {
                "id": "HIRP3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BW71",
                "type": "external"
            }
        ],
        "mass": 61957.0,
        "length": 556,
        "protein_name": "HIRA-interacting protein 3",
        "gene_name": "HIRIP3",
        "organism": "Human",
        "refseq_name": "HIRA-interacting protein 3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001184252",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001184252",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HIRIP3",
        "gene_names_refseq": "HIRIP3",
        "protein_names_uniprotkb": "HIRA-interacting protein 3",
        "protein_names_refseq": "HIRA-interacting protein 3 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8479)",
        "pathway_count": 1,
        "publication_count": 60,
        "publication_id_list": "15302935;16083285;16964243;17081983;17287340;17322306;17391060;17693683;18212344;18452278;18669648;18767875;19367720;19413330;19415658;19651622;19664994;19664995;19690332;20068231;20112406;21406692;23186163;23481700;24275569;25576301;26992070;27846572;28832583;29242379;29393594;29557506;29632046;29632711;30379171;30429286;31154438;31217245;31492838;31844290;31848261;32157095;32265295;32387766;32488085;32502341;32938616;32983136;33592498;33912179;33968037;33981976;34561969;34932366;35051231;35154160;35580925;38334665;40914422;9710638",
        "class_list": "",
        "function": "Histone chaperone that carries a H2A-H2B histone complex and facilitates its deposition onto chromatin., [UniProtKB, PubMed, PubMed]; Identification and Characterization of HIRIP3 as a Histone H2A Chaperone. Publication Status: Online-Only, [RefSeq, PubMed]; The HIRA protein shares sequence similarity with Hir1p and Hir2p, the two corepressors of histone gene transcription characterized in the yeast, Saccharomyces cerevisiae. The structural features of the HIRA protein suggest that it may function as part of a multiprotein complex. Several cDNAs encoding HIRA-interacting proteins, or HIRIPs, have been identified. In vitro, the protein encoded by this gene binds HIRA, as well as H2B and H3 core histones, indicating that a complex containing HIRA-HIRIP3 could function in some aspects of chromatin and histone metabolism. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 41,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "H3BSR3;O75707;O75708",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000511 H2A-H2B histone complex chaperone activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus",
        "go_biological_process": "GO:0006325 chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q9BW71-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NRM6-1",
        "uniprot_id": [
            {
                "id": "I17RB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NRM6",
                "type": "external"
            }
        ],
        "mass": 55885.0,
        "length": 502,
        "protein_name": "Interleukin-17 receptor B",
        "gene_name": "IL17RB",
        "organism": "Human",
        "refseq_name": "interleukin-17 receptor B precursor",
        "refseq_ac": [
            {
                "id": "NP_061195",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061195",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IL17RB; CRL4; EVI27; IL17BR; PRO19612",
        "gene_names_refseq": "CRL4; EVI27; IL17BR; IL17RB; IL17RH1",
        "protein_names_uniprotkb": "Interleukin-17 receptor B; Cytokine receptor-like 4; IL-17 receptor B; IL-17 receptor homolog 1; IL-17B receptor; IL-17RB; IL-17Rh1; IL17Rh1; Interleukin-17B receptor",
        "protein_names_refseq": "IL-17 receptor B; IL-17 receptor homolog 1; IL-17B receptor; IL-17RB; IL-17Rh1; cytokine receptor CRL4; cytokine receptor-like 4; interleukin 17 receptor homolog 1; interleukin-17 receptor B precursor; interleukin-17B receptor",
        "tax_id": 9606,
        "disease": "interstitial lung disease (Disease Ontology:DOID:3082)",
        "pathway": " (hsa:55540);  (R-HSA-448424)",
        "pathway_count": 2,
        "publication_count": 41,
        "publication_id_list": "10.1101/2023.09.13.557529;10749887;10815801;11058597;11237011;11574464;12975309;14759258;15340161;16397230;16785495;21993848;21993849;22070932;22299025;23481700;23834281;24120361;24190977;25502872;26375851;28228285;28832583;29242379;29557506;30315122;31844290;32350084;32983136;33691108;35251023;35487060;35494241;35580925;36010968;36241641;37074911;37448179;38600236;39010112;8777726",
        "class_list": "",
        "function": "CRL4-DCAF8L2 E3 ligase promotes ubiquitination and degradation of BARD1., [RefSeq, PubMed]; Endometrial senescence is mediated by interleukin 17 receptor B signaling. Erratum:[Cell Commun Signal. 2024 Jul 22;22(1):370. doi: 10.1186/s12964-024-01754-z. PMID: 39039545] Publication Status: Online-Only, [RefSeq, PubMed]; IL17RB expression is associated with malignant cancer behaviors and poor prognosis in oral cancer., [RefSeq, PubMed]; Receptor for the pro-inflammatory cytokines IL17B and IL17E. May play a role in controlling the growth and/or differentiation of hematopoietic cells., [UniProtKB, PubMed]; The protein encoded by this gene is a cytokine receptor. This receptor specifically binds to IL17B and IL17E, but does not bind to IL17 and IL17C. This receptor has been shown to mediate the activation of NF-kappaB and the production of IL8 induced by IL17E. The expression of the rat counterpart of this gene was found to be significantly up-regulated during intestinal inflammation, which suggested the immunoregulatory activity of this receptor. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription-coupled DNA-protein crosslink repair by CSB and CRL4[CSA]-mediated degradation., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 9562,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BPZ0;Q9NRL4;Q9NRM5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004896 cytokine receptor activity;GO:0030368 interleukin-17 receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane",
        "go_biological_process": "GO:0032736 positive regulation of interleukin-13 production;GO:0032754 positive regulation of interleukin-5 production;GO:0006952 defense response;GO:0001558 regulation of cell growth;GO:0070534 protein K63-linked ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q9NRM6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y5N5-1",
        "uniprot_id": [
            {
                "id": "HEMK2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y5N5",
                "type": "external"
            }
        ],
        "mass": 22957.0,
        "length": 214,
        "protein_name": "Methyltransferase HEMK2",
        "gene_name": "HEMK2",
        "organism": "Human",
        "refseq_name": "methyltransferase HEMK2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_037372",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037372",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEMK2; C21orf127; KMT9; N6AMT1; PRED28",
        "gene_names_refseq": "C21orf127; HEMK2; KMT9; MTQ2; N6AMT1; N6AMT; PRED28; PrmC; m.HsaHemK2P",
        "protein_names_uniprotkb": "Methyltransferase HEMK2; 2.1.1.-; HemK methyltransferase family member 2; Lysine N-methyltransferase 9; M.HsaHemK2P; Methylarsonite methyltransferase N6AMT1; Methyltransferase N6AMT1; Protein N(5)-glutamine methyltransferase",
        "protein_names_refseq": "HemK methyltransferase family member 2; N-6 adenine-specific DNA methyltransferase 1 (putative); N6-DNA-methyltransferase; lysine N-methyltransferase 9; methylarsonite methyltransferase N6AMT1; methyltransferase HEMK2 isoform 1; methyltransferase HEMK2; protein N(5)-glutamine methyltransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29104);  (R-HSA-156581);  (R-HSA-72764)",
        "pathway_count": 3,
        "publication_count": 44,
        "publication_id_list": "10331075;10358005;10514445;10644686;10978155;11511179;12163696;12590576;13981612;15788214;16267626;16407288;18539146;1861871;2006156;20606008;21193388;23665909;24734162;25851604;25997655;27570878;29557506;30017583;30392959;31061526;31466382;31632689;31636962;31844290;32157095;32203414;32502341;32969463;34087483;34948388;35256595;36681142;38284488;7990965;8968737;9175157;9586999;9712840",
        "class_list": "",
        "function": "Arsenic metabolism, N6AMT1 and AS3MT single nucleotide polymorphisms, and their interaction on gestational diabetes mellitus in Chinese pregnant women., [RefSeq, PubMed]; Distinct specificities of the HEMK2 protein methyltransferase in methylation of glutamine and lysine residues., [RefSeq, PubMed]; Five N6AMT1 single nucleotide polymorphisms and two N6AMT1 haplotypes were significantly associated with the percentage of methylarsonic acid in urine, even after adjusting for arsenic (+3 oxidation state) methyltransferase haplotype., [RefSeq, PubMed]; Methyltransferase that can methylate proteins and, to a lower extent, arsenic (PubMed:18539146, PubMed:21193388, PubMed:30017583, PubMed:31061526, PubMed:31636962). Catalytic subunit of a heterodimer with TRMT112, which monomethylates 'Lys-12' of histone H4 (H4K12me1), a modification present at the promoters of numerous genes encoding cell cycle regulators (PubMed:31061526). Catalytic subunit of a heterodimer with TRMT112, which catalyzes N5-methylation of Glu residue of proteins with a Gly-Gln-Xaa-Xaa-Xaa-Arg motif (PubMed:18539146, PubMed:31632689, PubMed:31636962). Methylates ETF1 on 'Gln-185'; ETF1 needs to be complexed to ERF3 in its GTP-bound form to be efficiently methylated (PubMed:18539146, PubMed:20606008, PubMed:31061526, PubMed:31636962). May also play a role in the modulation of arsenic-induced toxicity by mediating the conversion of monomethylarsonous acid (3+) into the less toxic dimethylarsonic acid (PubMed:21193388, PubMed:25997655). It however only plays a limited role in arsenic metabolism compared with AS3MT (PubMed:25997655)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; N6AMT1 converted monomethylarsonous acid to dimethylarsonic acid when overexpressed in UROtsa human urothelial cells. It is expressed in many human tissues at variable levels, supporting a potential participation in arsenic metabolism in vivo., [RefSeq, PubMed]; Reducing N6AMT1-mediated 6mA DNA modification promotes breast tumor progression via transcriptional repressing cell cycle inhibitors. Publication Status: Online-Only, [RefSeq, PubMed]; The human HemK2 protein methylates human and yeast eRF1.eRF3.GTP in vitro, and that the methyltransferase catalytic subunit can complement the growth defect of yeast strains deleted for mtq2., [RefSeq, PubMed]; This gene encodes an N(6)-adenine-specific DNA methyltransferase. The encoded enzyme may be involved in the methylation of release factor I during translation termination. This enzyme is also involved in converting the arsenic metabolite monomethylarsonous acid to the less toxic dimethylarsonic acid. Alternative splicing of this gene results in multiple transcript variants. A related pseudogene has been identified on chromosome 11. [provided by RefSeq, Mar 2023]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 18,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RA97;Q96F73",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0009007 site-specific DNA-methyltransferase (adenine-specific) activity;GO:0003676 nucleic acid binding;GO:0008276 protein methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0030791 arsenite methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032991 protein-containing complex;GO:0035657 eRF1 methyltransferase complex",
        "go_biological_process": "GO:0030307 positive regulation of cell growth;GO:0045815 transcription initiation-coupled chromatin remodeling;GO:0009404 toxin metabolic process;GO:0045814 negative regulation of gene expression, epigenetic;GO:0018872 arsonoacetate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q9Y5N5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0DMV9-1",
        "uniprot_id": [
            {
                "id": "HS71B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0DMV9",
                "type": "external"
            }
        ],
        "mass": 70052.0,
        "length": 641,
        "protein_name": "Heat shock 70 kDa protein 1B",
        "gene_name": "HSPA1B",
        "organism": "Human",
        "refseq_name": "heat shock 70 kDa protein 1B",
        "refseq_ac": [
            {
                "id": "NP_005337",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005337",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HSPA1B; HSP72",
        "gene_names_refseq": "HSP70-1B; HSP70-1; HSP70-2; HSP70.1; HSP70.2; HSP72; HSPA1B; HSPA1; HSX70",
        "protein_names_uniprotkb": "Heat shock 70 kDa protein 1B; HSP70-2; HSP70.2; Heat shock 70 kDa protein 2; Heat shock protein family A member 1B",
        "protein_names_refseq": "HSP70-1/HSP70-2; HSP70.1/HSP70.2; Heat shock 70 kDa protein 1A; heat shock 70 kDa protein 1/2; heat shock 70 kDa protein 1A/1B; heat shock 70 kDa protein 1B; heat shock 70 kDa protein 2; heat shock 70kD protein 1B; heat shock 70kDa protein 1B; heat shock protein family A member 1B",
        "tax_id": 9606,
        "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stroke (Disease Ontology:DOID:0051061); congenital anomalies of the kidney and urinary tract (Disease Ontology:DOID:0080205); urinary tract infection (Disease Ontology:DOID:0080784); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); graft-versus-host disease (Disease Ontology:DOID:0081267); pneumoconiosis (Disease Ontology:DOID:10316); Alzheimer's disease (Disease Ontology:DOID:10652); toxic shock syndrome (Disease Ontology:DOID:14115); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung small cell carcinoma (Disease Ontology:DOID:5409); schizophrenia (Disease Ontology:DOID:5419); type 2 diabetes mellitus (Disease Ontology:DOID:9352); senile cataract (Disease Ontology:DOID:9669); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:3303);  (hsa:3304);  (R-HSA-3371453);  (R-HSA-3371497);  (R-HSA-3371568);  (R-HSA-3371571);  (R-HSA-6798695);  (R-HSA-9833482);  (R-HSA-9841251);  (R-HSA-9918487)",
        "pathway_count": 10,
        "publication_count": 313,
        "publication_id_list": "10082513;10216320;10348343;10400669;10620360;10626894;10648614;10747884;10848580;10866685;10954706;11096080;11134010;11139588;11152499;11156368;11238103;11238927;11274138;11278865;11313968;11337501;11350938;11438540;11447121;11500375;11583998;11589254;11701661;11747420;11751894;11781817;11909525;11939789;11985496;12231563;12397061;12781197;12853476;12882984;12917326;12974469;13486053;1373135;14585331;14656967;1493716;15158436;15159550;15229216;15270074;15299030;15364926;15381148;15383005;15591061;15737233;15752359;15760475;15802566;1586970;15907845;15963462;1607379;16179258;16179259;16278218;1628823;16373505;16403413;16431927;16537599;16600570;16717090;1695551;16982605;1700760;17079286;17081983;17182002;17196820;17216044;17233114;17289661;1754405;17591767;17804755;18096616;18215318;18235501;18235502;18243712;18254226;18369606;18550409;18620420;18635947;18691976;18835251;18957415;19229036;19229320;19359544;19416861;19608861;19710021;19733181;19804757;19838063;19914676;20006655;20038533;20053985;20068231;20072699;20179333;20223214;20305658;20395957;20519500;20685959;21072047;21081504;21123651;21158691;21183720;21294215;21376746;21518807;21608060;21636578;21700222;21796517;21937648;21978664;21994559;22011577;22214662;22266222;22318716;22433123;22465953;2247437;22528486;22541429;22735644;22768106;22791416;22905912;22940245;22967762;22986343;23084476;23229543;23271734;23349634;23349863;23650620;23665396;23732991;23921388;23973223;24012426;24129315;24270810;24318877;24347309;24613385;24623135;24659800;24694367;24753571;24790089;2538825;25653431;25848059;25940345;26073023;26203193;26313416;26432638;26446704;26488609;26716879;26735137;26817845;26865365;27133716;27137183;27208315;27269119;27423063;27426517;27462449;27566657;27663436;27708256;27974558;28069888;28083797;28167698;28281686;28301631;28510447;28755533;28765891;28919297;29117567;29170442;29175459;29231267;29348664;29394925;29395325;29440070;29493099;29501855;29741879;29790264;30174290;30197098;30397120;30770398;31031002;31110491;31141847;31373491;31731497;31826031;32016915;32093270;32119511;32302062;32320027;32448030;32544881;32716602;32801355;32890404;32982970;33043033;33214551;33298915;33592498;33717175;33808629;33911136;33912179;33936100;34019948;34087483;34171305;34174402;34292443;34357683;34405274;34433824;34696522;34725712;34974812;35083852;35138101;35585045;35685460;35947956;36291674;36345598;36553658;36712380;37127961;37217939;37283123;37938771;38177122;6645495;6891012;7491766;7515177;7545299;7565688;7585962;7693978;7737357;7903669;8157723;8282004;8455624;8560673;8576172;8576179;8661426;8692836;8721986;8810342;8910500;8946918;9034343;9079663;9222609;9305631;9442054;9464360;9464361;9499401;9521856;9528799;9649501;9667968;9687506;9737981;9819388;9873016;9920933",
        "class_list": "",
        "function": "(Microbial infection) In case of rotavirus A infection, serves as a post-attachment receptor for the virus to facilitate entry into the cell., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Analysis of HSPA1B (+1267A>G) Genetic Polymorphism in Patients with Vibration Disease in Combination with Metabolic Syndrome., [RefSeq, PubMed]; Analysis of the heat shock protein 70 (HSP70) genetic variants in nonsegmental vitiligo patients., [RefSeq, PubMed]; Diagnostic and Prognostic Risk Assessment of Heat Shock Protein HSPA1B rs2763979 Gene Variant in Asthma. Publication Status: Online-Only, [RefSeq, PubMed]; Interaction of HSP70-2 gene polymorphism with body mass index and alcohol consumption on the prognosis of Uyghur patients with ischemic heart failure., [RefSeq, PubMed]; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis and ADP release, mediated by co-chaperones. The co-chaperones have been shown to not only regulate different steps of the ATPase cycle, but they also have an individual specificity such that one co-chaperone may promote folding of a substrate while another may promote degradation. The affinity for polypeptides is regulated by its nucleotide bound state. In the ATP-bound form, it has a low affinity for substrate proteins. However, upon hydrolysis of the ATP to ADP, it undergoes a conformational change that increases its affinity for substrate proteins. It goes through repeated cycles of ATP hydrolysis and nucleotide exchange, which permits cycles of substrate binding and release. The co-chaperones are of three types: J-domain co-chaperones such as HSP40s (stimulate ATPase hydrolysis by HSP70), the nucleotide exchange factors (NEF) such as BAG1/2/3 (facilitate conversion of HSP70 from the ADP-bound to the ATP-bound state thereby promoting substrate release), and the TPR domain chaperones such as HOPX and STUB1 (PubMed:24012426, PubMed:24318877, PubMed:26865365). Maintains protein homeostasis during cellular stress through two opposing mechanisms: protein refolding and degradation. Its acetylation/deacetylation state determines whether it functions in protein refolding or protein degradation by controlling the competitive binding of co-chaperones HOPX and STUB1. During the early stress response, the acetylated form binds to HOPX which assists in chaperone-mediated protein refolding, thereafter, it is deacetylated and binds to ubiquitin ligase STUB1 that promotes ubiquitin-mediated protein degradation (PubMed:27708256). Regulates centrosome integrity during mitosis, and is required for the maintenance of a functional mitotic centrosome that supports the assembly of a bipolar mitotic spindle (PubMed:27137183). Enhances STUB1-mediated SMAD3 ubiquitination and degradation and facilitates STUB1-mediated inhibition of TGF-beta signaling (PubMed:24613385). Essential for STUB1-mediated ubiquitination and degradation of FOXP3 in regulatory T-cells (Treg) during inflammation (PubMed:23973223)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Next Generation Sequencing of Genotype Variants and Genetic Association between Heat Shock Proteins HSPA1B Single Nucleotide Polymorphism at the g.31829044 Locus and Heat Tolerance: A Pilot Quasi-Experimental Study. Publication Status: Online-Only, [RefSeq, PubMed]; This intronless gene encodes a 70kDa heat shock protein which is a member of the heat shock protein 70 family. In conjuction with other heat shock proteins, this protein stabilizes existing proteins against aggregation and mediates the folding of newly translated proteins in the cytosol and in organelles. It is also involved in the ubiquitin-proteasome pathway through interaction with the AU-rich element RNA-binding protein 1. The gene is located in the major histocompatibility complex class III region, in a cluster with two closely related genes which encode similar proteins. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
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        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 15,
        "glyco_site_count": 4,
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        "secondary_ac_list": "B4E3B6;P08107;P19790;Q5JQI4;Q5SP17;Q9UQL9;Q9UQM0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0055131 C3HC4-type RING finger domain binding;GO:0003723 RNA binding;GO:0005102 signaling receptor binding;GO:0005524 ATP binding;GO:0019899 enzyme binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0090084 negative regulation of inclusion body assembly;GO:0008285 negative regulation of cell population proliferation;GO:0010628 positive regulation of gene expression;GO:0043066 negative regulation of apoptotic process;GO:0034605 cellular response to heat",
        "synthesized_glycan_count": 0,
        "hit_score": 32.0,
        "record_id": "P0DMV9-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95757-1",
        "uniprot_id": [
            {
                "id": "HS74L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95757",
                "type": "external"
            }
        ],
        "mass": 94512.0,
        "length": 839,
        "protein_name": "Heat shock 70 kDa protein 4L",
        "gene_name": "HSPA4L",
        "organism": "Human",
        "refseq_name": "heat shock 70 kDa protein 4L isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001304310",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304310",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HSPA4L; APG1; HSPH3; OSP94",
        "gene_names_refseq": "APG-1; APG1; HSPA4L; HSPH3; Osp94",
        "protein_names_uniprotkb": "Heat shock 70 kDa protein 4L; HSPA4-like protein; Heat shock 70-related protein APG-1; Heat shock protein family H member 3; Heat-shock protein family A member 4-like protein; Osmotic stress protein 94",
        "protein_names_refseq": "HSPA4-like protein; heat shock 70 kDa protein 4-like protein; heat shock 70 kDa protein 4L isoform 2; heat shock 70 kDa protein 4L; heat shock 70-related protein APG-1; heat shock 70kDa protein 4-like; heat shock protein (hsp110 family); heat shock protein family H member 3; heat-shock protein family A member 4-like protein; osmotic stress protein 94; testis tissue sperm-binding protein Li 64n",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22824);  (R-HSA-3371453)",
        "pathway_count": 2,
        "publication_count": 111,
        "publication_id_list": "10524232;10954706;11237011;11747420;12853476;12917326;12952923;12974469;15364926;15802566;1586970;16278218;17525332;1754405;18212344;18235501;18235502;18550409;18663603;18669648;19169850;19229036;19914676;20068231;22424782;22465953;22541429;22544926;22735644;22940245;23186163;23301498;23349863;23481700;24091676;24714562;25418920;25576301;26154972;26375851;26486082;26728094;26768311;26811146;27600516;27846572;27920218;28228285;28467828;28510447;28514659;28832583;28834231;28860189;28904123;29242379;29351928;29393594;29508533;29557506;29632046;29786170;29789417;30315122;30379171;30484775;30524438;30637842;30779550;31217245;31844290;31899217;31937595;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32870666;32938616;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33912179;33968037;33981976;34019948;34087483;34171305;34357683;34405274;34509645;35051231;35138101;36010968;36215666;37938771;40596516;40914422;7585962;8721986;8946918;9305631;9873016;9920933",
        "class_list": "",
        "function": "A novel autocrine pathway of CD1d regulation by Hsp110., [RefSeq, PubMed]; Apg-1 knockdown sensitized myeloma cells to bortezomib treatment, which may provide a new approach in multiple myeloma treatment., [RefSeq, PubMed]; Decreased expression of HSPA4L in immature and asthenozoospermic spermatozoa was validated by western blot analysis. Functional analysis revealed a correlation between HSPA4L and sperm motility by Spearman correlation analysis and its involvement in sperm-oocyte penetration by the human sperm-hamster egg penetration test., [RefSeq, PubMed]; Findings indicate that miR-497 is a potent tumor suppressor that inhibits cancer phenotypes by targeting ANLN and HSPA4L in NPC., [RefSeq, PubMed]; HSP40 and HSP110 function together in protein homeostasis control. Publication Status: Online-Only, [RefSeq, PubMed]; Possesses chaperone activity in vitro where it inhibits aggregation of citrate synthase., [UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is heat shock inducible and may act as a chaperone. The encoded protein can protect the heat-shocked cell against the harmful effects of aggregated proteins. This gene is highly expressed in leukemia cells and may be a good target for therapeutic intervention. Several transcripts encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2ICT2;Q4W5M5;Q8IWA2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000774 adenyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006457 protein folding;GO:0006986 response to unfolded protein",
        "synthesized_glycan_count": 0,
        "hit_score": 11.4,
        "record_id": "O95757-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P22692-1",
        "uniprot_id": [
            {
                "id": "IBP4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P22692",
                "type": "external"
            }
        ],
        "mass": 27934.0,
        "length": 258,
        "protein_name": "Insulin-like growth factor-binding protein 4",
        "gene_name": "IGFBP4",
        "organism": "Human",
        "refseq_name": "insulin-like growth factor-binding protein 4 precursor",
        "refseq_ac": [
            {
                "id": "NP_001543",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001543",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IGFBP4; IBP4",
        "gene_names_refseq": "BP-4; HT29-IGFBP; IBP4; IGFBP-4; IGFBP4",
        "protein_names_uniprotkb": "Insulin-like growth factor-binding protein 4; IBP-4; IGF-binding protein 4; IGFBP-4",
        "protein_names_refseq": "IBP-4; IGF-binding protein 4; insulin-like growth factor-binding protein 4 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3487);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 3,
        "publication_count": 106,
        "publication_id_list": "10.1038/emboj.2013.79;10026136;10077652;10218588;10512690;10614670;10681634;10810289;10898936;10912521;10951195;10990447;11158056;11250653;11264294;11316783;11522292;11606061;11739083;11751371;11788658;12241545;12379487;12466191;12810533;12904166;1370451;1383255;15126567;15308688;15469690;15485880;15525596;15642270;16924115;1704481;17047378;1707125;1709161;1709585;17249697;1726835;17312271;17985932;22898188;23481700;23584533;2476804;2479552;25502872;25576301;26091039;26754738;28832583;28904123;29242379;29314611;29557506;29786170;30429286;30833945;31154438;31530632;31611695;31848261;32157095;32350084;32488085;32938616;32983136;33968037;34087483;34357683;34433824;35051231;35251023;35580925;37176126;37433992;37605556;37762544;37938771;38665916;39244846;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;8781553;8817670;8894645;8964575;9048882;9497324;9615225;9709957;9733769;9786878;9922210",
        "class_list": "",
        "function": "AKAP12 and IGFBP4 Are Prognostic Factors for Chronic Lymphocytic Leukemia., [RefSeq, PubMed]; IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors., [UniProtKB]; Increased Levels of Circulating IGFBP4 and ANGPTL8 with a Prospective Role in Diabetic Nephropathy. Publication Status: Online-Only, [RefSeq, PubMed]; PAPP-A-Specific IGFBP-4 Proteolysis in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Specific cleavage of IGFBP-4 by papp-a in nervous tissue., [RefSeq, PubMed]; The RNA binding protein MEX3A promotes tumor progression of breast cancer by post-transcriptional regulation of IGFBP4., [RefSeq, PubMed]; This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP domain and a thyroglobulin type-I domain. The protein binds both insulin-like growth factors (IGFs) I and II and circulates in the plasma in both glycosylated and non-glycosylated forms. Binding of this protein prolongs the half-life of the IGFs and alters their interaction with cell surface receptors. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 1,
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        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
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        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0N9W2;B4E351;Q5U012;Q9UCL6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0031994 insulin-like growth factor I binding;GO:0031995 insulin-like growth factor II binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0007165 signal transduction;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0043567 regulation of insulin-like growth factor receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "P22692-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P48723-1",
        "uniprot_id": [
            {
                "id": "HSP13_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P48723",
                "type": "external"
            }
        ],
        "mass": 51927.0,
        "length": 471,
        "protein_name": "Heat shock 70 kDa protein 13",
        "gene_name": "HSPA13",
        "organism": "Human",
        "refseq_name": "heat shock 70 kDa protein 13 precursor",
        "refseq_ac": [
            {
                "id": "NP_008879",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008879",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HSPA13; STCH",
        "gene_names_refseq": "HSPA13; STCH",
        "protein_names_uniprotkb": "Heat shock 70 kDa protein 13; Heat shock protein family A member 13; Microsomal stress-70 protein ATPase core; Stress-70 protein chaperone microsome-associated 60 kDa protein",
        "protein_names_refseq": "heat shock 70 kDa protein 13 precursor; heat shock 70 kDa protein 13; heat shock protein 70kDa family, member 13; heat shock protein family A member 13; microsomal stress 70 protein ATPase core; stress 70 protein chaperone, microsome-associated, 60kDa; stress-70 protein chaperone microsome-associated 60 kDa protein; testis secretory sperm-binding protein Li 199a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6782);  (R-HSA-3371453)",
        "pathway_count": 2,
        "publication_count": 99,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10675567;10954706;11319647;11747420;12853476;12917326;12974469;15364926;15802566;1586970;16278218;1754405;18235501;18235502;18292551;18512783;18550409;19229036;19914676;20068231;22465953;22541429;22735644;22940245;23090970;23349863;23584533;24190977;25502872;25505266;25645385;26375851;26992070;27726376;28063628;28467828;28514659;28832583;28834231;28855257;28904123;29242379;29314611;29557506;29632046;29632711;29741879;29789417;30429286;30573663;30626607;30779550;31217245;31844290;31848261;32157095;32161166;32350084;32488085;32547538;32938616;32983136;33392160;33592498;33672238;33717175;33936100;33968037;33981976;34019948;34087483;34357683;34433824;34725712;34932366;35051231;35154160;35251023;35254053;35289036;35580925;36215666;36241641;36244454;37074911;38665916;39531497;39894887;40596516;40914422;7585962;8131751;8721986;8946918;9305631;9873016;9920933",
        "class_list": "",
        "function": "Differential Effects of STCH and Stress-Inducible Hsp70 on the Stability and Maturation of NKCC2. Publication Status: Online-Only, [RefSeq, PubMed]; Has peptide-independent ATPase activity., [UniProtKB]; Heat shock protein Hspa13 regulates endoplasmic reticulum and cytosolic proteostasis through modulation of protein translocation., [RefSeq, PubMed]; Hspa13 Promotes Plasma Cell Production and Antibody Secretion. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The protein encoded by this gene is a member of the heat shock protein 70 family and is found associated with microsomes. Members of this protein family play a role in the processing of cytosolic and secretory proteins, as well as in the removal of denatured or incorrectly-folded proteins. The encoded protein contains an ATPase domain and has been shown to associate with a ubiquitin-like protein. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 2,
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        "total_n_glycosites": 3,
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        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 11,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R616;Q8NE40",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0031072 heat shock protein binding;GO:0044183 protein folding chaperone",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0042026 protein refolding",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "P48723-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q12988-1",
        "uniprot_id": [
            {
                "id": "HSPB3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q12988",
                "type": "external"
            }
        ],
        "mass": 16966.0,
        "length": 150,
        "protein_name": "Heat shock protein beta-3",
        "gene_name": "HSPB3",
        "organism": "Human",
        "refseq_name": "heat shock protein beta-3",
        "refseq_ac": [
            {
                "id": "NP_006299",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006299",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HSPB3; HSP27; HSPL27",
        "gene_names_refseq": "DHMN2C; HMN2C; HMND4; HSPB3; HSPL27",
        "protein_names_uniprotkb": "Heat shock protein beta-3; HSP 17; Heat shock 17 kDa protein; Heat shock protein family B member 3; HspB3; Protein 3",
        "protein_names_refseq": "HSP 17; heat shock 17 kDa protein; heat shock 27kDa protein 3; heat shock protein beta-3; heat shock protein family B member 3; protein 3",
        "tax_id": 9606,
        "disease": "autosomal dominant distal hereditary motor neuronopathy 4 (Disease Ontology:DOID:0111209)",
        "pathway": " (hsa:8988)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "16225851;19464326;20142617;29393594;31709619;33958580;36010968;36768927;37804589;8972725;9858786",
        "class_list": "",
        "function": "An HSPB3 mutation associated with an axonal motor neuropathy, [RefSeq, PubMed]; Evaluation of the Small Heat Shock Protein Family Members HSPB2 and HSPB3 in Bladder Cancer Prognosis and Progression. Publication Status: Online-Only, [RefSeq, PubMed]; High HSPB3 expression is associated with poor relapse-free survival (RFS) and overall survival (OS) of patients with colorectal adenocarcinoma., [RefSeq, PubMed]; Inhibitor of actin polymerization., [UniProtKB]; Our results suggest that a variety of oligomers composed of different proportions of different sHSPs may form in cell types expressing multiple sHSPs., [RefSeq, PubMed]; PINK1 and Parkin rescue motor defects and mitochondria dysfunction induced by a patient-derived HSPB3 mutant in Drosophila models., [RefSeq, PubMed]; Small heat-shock protein HSPB3 promotes myogenesis by regulating the lamin B receptor. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a muscle-specific small heat shock protein. A mutation in this gene is the cause of autosomal dominant distal hereditary motor neuropathy type 2C.[provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0006986 response to unfolded protein",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q12988-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q4G112-1",
        "uniprot_id": [
            {
                "id": "HSF5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q4G112",
                "type": "external"
            }
        ],
        "mass": 65265.0,
        "length": 596,
        "protein_name": "Heat shock factor protein 5",
        "gene_name": "HSF5",
        "organism": "Human",
        "refseq_name": "heat shock factor protein 5",
        "refseq_ac": [
            {
                "id": "NP_001073908",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073908",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HSF5; HSTF5",
        "gene_names_refseq": "HSF 5; HSF5; HSTF 5",
        "protein_names_uniprotkb": "Heat shock factor protein 5; HSF 5; HSTF 5; Heat shock transcription factor 5",
        "protein_names_refseq": "heat shock factor protein 5; heat shock transcription factor family member 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:124535)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "32387766;33390814",
        "class_list": "",
        "function": "DNA-binding transcription factor that is essential for male fertility, spermatogenesis and meiotic prophase progression in spermatocytes under non-stress conditions. Positvely and negatively regulates gene expression to ensure progression of meiotic prophase beyond pachytene stage in spermatocytes., [UniProtKB, UniProtKB]; Heat shock factor 5 correlated with immune infiltration serves as a prognostic biomarker in lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 0,
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        "total_s_glycosites": 0,
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        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q08EH7;Q8N7V2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding;GO:0001216 DNA-binding transcription activator activity;GO:0001217 DNA-binding transcription repressor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0001741 XY body",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0007140 male meiotic nuclear division",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q4G112-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q58FG0-1",
        "uniprot_id": [
            {
                "id": "HS905_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q58FG0",
                "type": "external"
            }
        ],
        "mass": 38738.0,
        "length": 334,
        "protein_name": "Putative heat shock protein HSP 90-alpha A5",
        "gene_name": "HSP90AA5P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "HSP90AA5P; HSP90AE",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative heat shock protein HSP 90-alpha A5; Heat shock protein 90-alpha E; Heat shock protein 90Ae",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 8,
        "publication_id_list": "16269234;24715725;25418920;29557506;31844290;32387766;35051231;37217939",
        "class_list": "",
        "function": "Putative molecular chaperone that may promote the maturation, structural maintenance and proper regulation of specific target proteins., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q58FG0-1",
        "record_type": "protein",
        "filter_code": "0000000.0000110.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NHY5-1",
        "uniprot_id": [
            {
                "id": "HUS1B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NHY5",
                "type": "external"
            }
        ],
        "mass": 30982.0,
        "length": 278,
        "protein_name": "Checkpoint protein HUS1B",
        "gene_name": "HUS1B",
        "organism": "Human",
        "refseq_name": "checkpoint protein HUS1B",
        "refseq_ac": [
            {
                "id": "NP_683762",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_683762",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HUS1B",
        "gene_names_refseq": "HUS1B",
        "protein_names_uniprotkb": "Checkpoint protein HUS1B; hHUS1B",
        "protein_names_refseq": "HUS1 checkpoint homolog b; checkpoint protein HUS1B; hHUS1B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:135458)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11944979;14500360;20453000;26911255;28228285;28904123;29393594;29557506;30315122;32663249;32938616;33968037;35051231",
        "class_list": "",
        "function": "HUS1B directly interacts with RAD1, but not RAD9 or HUS1, whereas HUS1 can bind RAD1, RAD9, and another molecule of HUS1, suggesting that HUS1B cannot simply substitute for HUS1 in the complex., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Potentially functional variants in nucleotide excision repair pathway genes predict platinum treatment response of Chinese ovarian cancer patients., [RefSeq, PubMed]; The HUS1B promoter is hypomethylated in the placentas of low-birth-weight infants., [RefSeq, PubMed]; The protein encoded by this gene is most closely related to HUS1, a component of a cell cycle checkpoint protein complex involved in cell cycle arrest in response to DNA damage. This protein can interact with the check point protein RAD1 but not with RAD9. Overexpression of this protein has been shown to induce cell death, which suggests a related but distinct role of this protein, as compared to the HUS1. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T4Z2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0035861 site of double-strand break;GO:0030896 checkpoint clamp complex",
        "go_biological_process": "GO:0000723 telomere maintenance;GO:0000724 double-strand break repair via homologous recombination;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:0006289 nucleotide-excision repair;GO:0033314 mitotic DNA replication checkpoint signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q8NHY5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O76014-1",
        "uniprot_id": [
            {
                "id": "KRT37_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O76014",
                "type": "external"
            }
        ],
        "mass": 49747.0,
        "length": 449,
        "protein_name": "Keratin, type I cuticular Ha7",
        "gene_name": "KRT37",
        "organism": "Human",
        "refseq_name": "keratin, type I cuticular Ha7",
        "refseq_ac": [
            {
                "id": "NP_003761",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003761",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KRT37; HHA7; HKA7; KRTHA7",
        "gene_names_refseq": "HA7; K37; KRT37; KRTHA7",
        "protein_names_uniprotkb": "Keratin, type I cuticular Ha7; Hair keratin, type I Ha7; K37; Keratin-37",
        "protein_names_refseq": "hair keratin, type I Ha7; keratin 37, type I; keratin, hair, acidic, 7; keratin, type I cuticular Ha7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8688);  (R-HSA-6805567);  (R-HSA-6809371)",
        "pathway_count": 3,
        "publication_count": 52,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11350120;11380615;11590230;12902340;15033990;15337775;15373777;15797384;15803139;16061697;16382671;16639001;1691188;1694855;1714783;17515931;17521629;17562024;17596512;18843291;19190773;19194479;20179351;20657595;20667819;20940292;21439340;21654840;21997417;23481192;23629652;2414304;25208914;25926655;26390218;27862975;31844290;35051231;41018975;7543090;8824274;8999895;9395522;9468612;9565599;9756910",
        "class_list": "",
        "function": "The protein encoded by this gene is a member of the keratin gene family. As a type I hair keratin, it is an acidic protein which heterodimerizes with type II keratins to form hair and nails. The type I hair keratins are clustered in a region of chromosome 17q12-q21 and have the same direction of transcription. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005198 structural molecule activity;GO:0030280 structural constituent of skin epidermis",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0070062 extracellular exosome;GO:0045095 keratin filament",
        "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "O76014-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15024-1",
        "uniprot_id": [
            {
                "id": "EXOS7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15024",
                "type": "external"
            }
        ],
        "mass": 31821.0,
        "length": 291,
        "protein_name": "Exosome complex component RRP42",
        "gene_name": "EXOSC7",
        "organism": "Human",
        "refseq_name": "exosome complex component RRP42",
        "refseq_ac": [
            {
                "id": "NP_055819",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055819",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EXOSC7; KIAA0116; RRP42",
        "gene_names_refseq": "EAP1; EXOSC7; RRP42; Rrp42p; hRrp42p; p8",
        "protein_names_uniprotkb": "Exosome complex component RRP42; Exosome component 7; Ribosomal RNA-processing protein 42; p8",
        "protein_names_refseq": "exosome complex component RRP42; exosome complex exonuclease RRP42; ribosomal RNA-processing protein 42",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23016);  (R-HSA-380994);  (R-HSA-429958);  (R-HSA-450385);  (R-HSA-450513);  (R-HSA-450604);  (R-HSA-6791226);  (R-HSA-9930044)",
        "pathway_count": 8,
        "publication_count": 184,
        "publication_id_list": "10330172;10958673;11283721;11719186;11812149;11922599;12068309;12150911;12198173;12324455;12419256;12639954;12646273;12705825;12748283;14688255;14742429;14749774;14976220;15014438;15068804;15117938;15175153;15231747;15273322;15385533;15475613;15514971;15538381;15687258;15769464;15944294;16037817;16043514;16141059;16262601;16364914;16648466;16687408;16738141;16912112;16931790;16989641;17030608;17133347;17174896;17189298;17245413;17353269;17369404;17412707;17545563;18065403;18285520;18326031;18367721;18438418;18441014;18481987;18684992;18840095;19060886;19106111;19141871;19198587;19225159;19239894;19332556;19564402;19608861;19651622;19729507;19801658;19854161;20022965;20038530;20056613;20068231;20361218;20531386;20531389;20798176;20805244;20819938;21036871;21063389;21097556;21136679;21705430;21855801;21876179;22072790;22190735;22195017;22223895;22424782;22544926;22802018;22819556;22916032;22978410;23186163;23223233;23269699;23301498;23439679;23481700;23482395;2388630;24366607;24424021;24550520;24715725;25525153;25576301;25578728;25880248;25969445;26154972;26237581;26375851;2663993;2664463;26992070;27434818;27543614;27600516;27846572;27862975;27871484;27920218;28218747;28228285;28510447;28832583;28834231;28904123;29242379;29298432;29413899;29437277;29632046;29632711;29786170;29906447;30315122;30429286;30524438;30779550;31222486;31530632;31844290;31848261;31950173;31998317;32157095;32357974;32387766;32488085;32502341;3260265;32938616;32983136;33141586;33392160;33537174;33717175;33767452;33913806;33936100;33968037;33981976;34087483;34171305;34405274;34509645;35318648;35561310;35580925;36010968;36241641;37875486;40914422;9482744",
        "class_list": "",
        "function": "Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. The catalytic inactive RNA exosome core complex of 9 subunits (Exo-9) is proposed to play a pivotal role in the binding and presentation of RNA for ribonucleolysis, and to serve as a scaffold for the association with catalytic subunits and accessory proteins or complexes., [UniProtKB]; The association of hCsl4p with the exosome is mediated by protein-protein interactions with hRrp42p and hRrp46p., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
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        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96E72",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0000175 3'-5'-RNA exonuclease activity;GO:0035925 mRNA 3'-UTR AU-rich region binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0071028 nuclear mRNA surveillance;GO:0034473 U1 snRNA 3'-end processing;GO:0034476 U5 snRNA 3'-end processing;GO:0006396 RNA processing;GO:0006364 rRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 18.7,
        "record_id": "Q15024-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UL51-1",
        "uniprot_id": [
            {
                "id": "HCN2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UL51",
                "type": "external"
            }
        ],
        "mass": 96950.0,
        "length": 889,
        "protein_name": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2",
        "gene_name": "HCN2",
        "organism": "Human",
        "refseq_name": "potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2",
        "refseq_ac": [
            {
                "id": "NP_001185",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HCN2; BCNG2",
        "gene_names_refseq": "BCNG-2; BCNG2; EIG17; FEB2; GEFSP11; HAC-1; HCN2",
        "protein_names_uniprotkb": "Potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2; BCNG-2; Brain cyclic nucleotide-gated channel 2",
        "protein_names_refseq": "brain cyclic nucleotide-gated channel 2; hyperpolarization activated cyclic nucleotide gated potassium channel 2; potassium/sodium hyperpolarization-activated cyclic nucleotide-gated channel 2",
        "tax_id": 9606,
        "disease": "familial febrile seizures 2 (Disease Ontology:DOID:0111310); dermatitis (Disease Ontology:DOID:2723); meningitis (Disease Ontology:DOID:9471)",
        "pathway": " (hsa:610);  (R-HSA-1296061)",
        "pathway_count": 2,
        "publication_count": 42,
        "publication_id_list": "10228147;10524219;11328811;16079136;16387796;18669648;21347269;22006928;22131395;24324597;25197093;25576301;26280531;26546007;26992070;28218747;28657654;28832583;28834231;29064616;29242379;29393594;29437277;29463886;29508533;30192525;31530632;31682955;31848261;31916853;32157095;32161166;32543742;33592498;33912179;33968037;34171305;35051231;35662339;36010968;37217939;9630217",
        "class_list": "",
        "function": "Downregulation of hyperpolarization-activated cyclic nucleotide-gated channels (HCN) in the hippocampus of patients with medial temporal lobe epilepsy and hippocampal sclerosis (MTLE-HS)., [RefSeq, PubMed]; Effects of HCN2 Mutations on Dendritic Excitability and Synaptic Plasticity: A Computational Study., [RefSeq, PubMed]; HCN2 channel-induced rescue of brain, eye, heart and gut teratogenesis caused by nicotine, ethanol and aberrant notch signalling., [RefSeq, PubMed]; Hyperpolarization-activated ion channel that is permeable to sodium and potassium ions. Displays lower selectivity for K(+) over Na(+) ions (PubMed:10228147, PubMed:22006928). Contributes to the native pacemaker currents in heart (If) and in neurons (Ih) (PubMed:10228147, PubMed:10524219). Can also transport ammonium in the distal nephron (By similarity). Involved in the initiation of neuropathic pain in sensory neurons (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Overexpression of TBX3 and HCN2 could reprogram human-induced pluripotent stem cells-derived cardiomyocytes into pacemaker-like cells, [RefSeq, PubMed]; The protein encoded by this gene is a hyperpolarization-activated cation channel involved in the generation of native pacemaker activity in the heart and in the brain. The encoded protein is activated by cAMP and can produce a fast, large current. Defects in this gene were noted as a possible cause of some forms of epilepsy. [provided by RefSeq, Jan 2017]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60742;O60743;O75267;Q9UBS2",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0030165 PDZ domain binding;GO:0005248 voltage-gated sodium channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body;GO:0043198 dendritic shaft",
        "go_biological_process": "GO:0007267 cell-cell signaling;GO:0042391 regulation of membrane potential;GO:0071320 cellular response to cAMP;GO:0035725 sodium ion transmembrane transport;GO:0009410 response to xenobiotic stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q9UL51-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WYK2-1",
        "uniprot_id": [
            {
                "id": "JDP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WYK2",
                "type": "external"
            }
        ],
        "mass": 18704.0,
        "length": 163,
        "protein_name": "Jun dimerization protein 2",
        "gene_name": "JDP2",
        "organism": "Human",
        "refseq_name": "jun dimerization protein 2 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001128519",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128519",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "JDP2",
        "gene_names_refseq": "JDP2; JUNDM2",
        "protein_names_uniprotkb": "Jun dimerization protein 2",
        "protein_names_refseq": "jun dimerization protein 2 isoform a; progesterone receptor co-activator",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:122953)",
        "pathway_count": 1,
        "publication_count": 42,
        "publication_id_list": "11237011;11602244;12225289;12707301;12903123;16026868;16518400;18307971;18671972;21463260;23186163;23481700;23530091;24715725;25218447;25576301;25755297;26154972;27862975;27920218;28832583;29508533;29557506;29632711;29786170;30429286;30877624;31434880;31844290;32150333;32502341;32938616;33108704;33123756;33141586;33298915;33936100;34211107;35051231;35318648;35580925;37179125",
        "class_list": "",
        "function": "Component of the AP-1 transcription factor that represses transactivation mediated by the Jun family of proteins. Involved in a variety of transcriptional responses associated with AP-1 such as UV-induced apoptosis, cell differentiation, tumorigenesis and antitumogeneris. Can also function as a repressor by recruiting histone deacetylase 3/HDAC3 to the promoter region of JUN. May control transcription via direct regulation of the modification of histones and the assembly of chromatin., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Down-regulated lncRNA AGAP2-AS1 contributes to pre-eclampsia as a competing endogenous RNA for JDP2 by impairing trophoblastic phenotype., [RefSeq, PubMed]; JDP2 is directly regulated by ATF4 and modulates TRAIL sensitivity by suppressing the ATF4-DR5 axis., [RefSeq, PubMed]; JDP2 is downregulated in HCC tissues and cells, and overexpressed JDP2 facilitated HCC cell invasion and EMT., [RefSeq, PubMed]; Palmitic acid-induced microRNA-143-5p expression promotes the epithelial-mesenchymal transition of retinal pigment epithelium via negatively regulating JDP2., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "J3KN58;O95430;Q9UIE4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0042826 histone deacetylase binding;GO:0043522 leucine zipper domain binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q8WYK2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75022-1",
        "uniprot_id": [
            {
                "id": "LIRB3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75022",
                "type": "external"
            }
        ],
        "mass": 69386.0,
        "length": 631,
        "protein_name": "Leukocyte immunoglobulin-like receptor subfamily B member 3",
        "gene_name": "LILRB3",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "LILRB3; ILT5; LIR3",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Leukocyte immunoglobulin-like receptor subfamily B member 3; CD85 antigen-like family member A; ILT-5; Immunoglobulin-like transcript 5; LIR-3; Leukocyte immunoglobulin-like receptor 3; Monocyte inhibitory receptor HL9",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:102725035);  (hsa:107987425);  (hsa:107987462);  (R-HSA-198933);  (R-HSA-6798695)",
        "pathway_count": 5,
        "publication_count": 107,
        "publication_id_list": "10499918;10746781;10941842;11237011;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12213321;12483297;12588680;14719373;14970179;15034010;15136729;15155468;15187158;15304001;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;16014749;16091383;16129954;16339513;16380601;16551255;16737824;16754721;16893496;16904340;16928187;17045824;17057721;17237375;17337780;18031695;18037897;18055229;18209062;18234675;18593354;19149696;19359216;19592130;20730098;21241660;21800138;21841309;21877119;22396535;23650620;23695528;23929856;24305946;24715725;25703557;25716998;26284469;26300885;28087737;28832583;28904123;29242379;29314611;29557506;30459171;31530632;31844290;32157095;32357974;32387766;32897882;32938616;32983136;33298915;33912179;34509645;34932366;35051231;35494241;35580925;36284347;7531291;7542404;8178173;8692836;8995416;9278324;9285412;9314561;9548455;9700512;9730896",
        "class_list": "",
        "function": "May act as receptor for class I MHC antigens. Becomes activated upon coligation of LILRB3 and immune receptors, such as FCGR2B and the B-cell receptor. Down-regulates antigen-induced B-cell activation by recruiting phosphatases to its immunoreceptor tyrosine-based inhibitor motifs (ITIM)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9J1P3;C9JIP1;O15471;Q86U49",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0038023 signaling receptor activity;GO:0032396 inhibitory MHC class I receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030667 secretory granule membrane",
        "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0006952 defense response;GO:0007166 cell surface receptor signaling pathway;GO:0002250 adaptive immune response;GO:0019221 cytokine-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 11.0,
        "record_id": "O75022-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6PI73-1",
        "uniprot_id": [
            {
                "id": "LIRA6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6PI73",
                "type": "external"
            }
        ],
        "mass": 52399.0,
        "length": 481,
        "protein_name": "Leukocyte immunoglobulin-like receptor subfamily A member 6",
        "gene_name": "LILRA6",
        "organism": "Human",
        "refseq_name": "leukocyte immunoglobulin-like receptor subfamily A member 6 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001347096",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001347096",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LILRA6; ILT8",
        "gene_names_refseq": "CD85b; ILT-8; ILT5; ILT8; LILRA6; LILRB6",
        "protein_names_uniprotkb": "Leukocyte immunoglobulin-like receptor subfamily A member 6; ILT-8; Immunoglobulin-like transcript 8; Leukocyte Ig-like receptor",
        "protein_names_refseq": "immunoglobulin-like transcript 5; immunoglobulin-like transcript 8; leucocyte Ig-like receptor A6; leukocyte Ig-like receptor; leukocyte immunoglobulin-like receptor subfamily A member 6 isoform 2 precursor; leukocyte immunoglobulin-like receptor, subfamily A (with TM domain), member 6; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79168);  (R-HSA-198933)",
        "pathway_count": 2,
        "publication_count": 91,
        "publication_id_list": "10499918;10746781;10941842;11237011;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12213321;12483297;12588680;14719373;14970179;15034010;15136729;15155468;15187158;15304001;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;16014749;16091383;16129954;16339513;16380601;16551255;16737824;16754721;16893496;16904340;16928187;17045824;17057721;17237375;17337780;18031695;18037897;18055229;18209062;18234675;18593354;19149696;19359216;19592130;19617579;20331378;20730098;21241660;21800138;21841309;21877119;22396535;23695528;23929856;24096970;24305946;25703557;25716998;26284469;26300885;27333811;27726376;29557506;32350084;32357974;32387766;32502341;33526815;36449053;7531291;7542404;8178173;8995416;9285412;9314561;9700512;9730896",
        "class_list": "",
        "function": "Allogeneic disparities in immunoglobulin-like transcript 5 induce potent antibody responses in hematopoietic stem cell transplant recipients, [RefSeq, PubMed]; Characterization of LILRB3 and LILRA6 allelic variants in the Japanese population., [RefSeq, PubMed]; Distinct frequency patterns of LILRB3 and LILRA6 allelic variants in Europeans., [RefSeq, PubMed]; LILRA6 copy number variation correlates with susceptibility to atopic dermatitis., [RefSeq, PubMed]; LILRA6 copy number variation may influence the level of the activating receptor on the cell surface, potentially affecting signaling upon LILRB3/A6 ligation, [RefSeq, PubMed]; May act as receptor for class I MHC antigens., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0032396 inhibitory MHC class I receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0002250 adaptive immune response;GO:0019221 cytokine-mediated signaling pathway;GO:0007166 cell surface receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 9.2,
        "record_id": "Q6PI73-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5VT66-1",
        "uniprot_id": [
            {
                "id": "MARC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5VT66",
                "type": "external"
            }
        ],
        "mass": 37499.0,
        "length": 337,
        "protein_name": "Mitochondrial amidoxime-reducing component 1",
        "gene_name": "MTARC1",
        "organism": "Human",
        "refseq_name": "mitochondrial amidoxime-reducing component 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_073583",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073583",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MTARC1; MARC1; MOSC1",
        "gene_names_refseq": "MARC1; MOSC1; MTARC1",
        "protein_names_uniprotkb": "Mitochondrial amidoxime-reducing component 1; 1.7.-.-; MOSC domain-containing protein 1; Moco sulfurase C-terminal domain-containing protein 1; Molybdenum cofactor sulfurase C-terminal domain-containing protein 1; mARC1",
        "protein_names_refseq": "MOCO sulphurase C-terminal domain containing 1; MOSC domain-containing protein 1, mitochondrial; mitochondrial amidoxime-reducing component 1 precursor; moco sulfurase C-terminal domain-containing protein 1; molybdenum cofactor sulfurase C-terminal domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64757);  (R-HSA-211945)",
        "pathway_count": 2,
        "publication_count": 77,
        "publication_id_list": "10445380;10945627;11154734;11237011;11422004;12725862;12732646;1351198;15350128;15492766;15523003;15535985;16614850;16765324;17400359;18254726;18256025;18285471;19053771;19588076;19764817;20007405;20068231;20177059;20422440;20542992;20861021;20877624;21029045;22700792;22813719;23086957;23616950;23953689;24423752;24677340;24900196;25144769;25255805;25425164;25446851;25576301;25807930;25923589;26768311;26992070;2897122;29314611;29557506;29786170;30397129;30484775;32152082;32171872;32187464;32205870;32210741;32387766;32983136;33968037;33981976;34087483;34171305;34509645;35051231;36215666;36241641;38340654;38375985;38437227;38619429;38723751;7980644;8985016;9169443;9367528;9653080",
        "class_list": "",
        "function": "Arc1(MOSC-1) and Arc2(MOSC-2) proteins are monomeric in their active forms., [RefSeq, PubMed]; Biochemical and functional characterization of the p.A165T missense variant of mitochondrial amidoxime-reducing component 1., [RefSeq, PubMed]; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:19053771, PubMed:21029045, PubMed:30397129). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:19053771). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:19053771, PubMed:21029045)., [UniProtKB, PubMed, PubMed, PubMed]; Divergent role of Mitochondrial Amidoxime Reducing Component 1 (MARC1) in human and mouse. Publication Status: Online-Only, [RefSeq, PubMed]; Fatty liver disease protective MTARC1 p.A165T variant reduces the protein stability of MTARC1., [RefSeq, PubMed]; MARC1 in MASLD: Modulation of lipid accumulation in human hepatocytes and adipocytes. Publication Status: Online-Only, [RefSeq, PubMed]; Mitochondrial amidoxime-reducing component 1 p.Ala165Thr increases protein degradation mediated by the proteasome., [RefSeq, PubMed]; Molybdoprotein mARC1 is involved in the activation of N-hydroxylated prodrugs., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K447;B2D078;Q5VVS9;Q5VVT0;Q5VVT1;Q8N9P5;Q96FN8;Q9H6C7",
        "ec_number_list": [
            {
                "id": "1.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2",
                "type": "external"
            },
            {
                "id": "1.7.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0008940 nitrate reductase activity;GO:0030170 pyridoxal phosphate binding;GO:0043546 molybdopterin cofactor binding;GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:1903958 nitric-oxide synthase complex",
        "go_biological_process": "GO:0006809 nitric oxide biosynthetic process;GO:0042126 nitrate metabolic process;GO:0051410 detoxification of nitrogen compound;GO:0070458 cellular detoxification of nitrogen compound",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q5VT66-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99706-1",
        "uniprot_id": [
            {
                "id": "KI2L4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99706",
                "type": "external"
            }
        ],
        "mass": 41487.0,
        "length": 377,
        "protein_name": "Killer cell immunoglobulin-like receptor 2DL4",
        "gene_name": "KIR2DL4",
        "organism": "Human",
        "refseq_name": "killer cell immunoglobulin-like receptor 2DL4 isoform c precursor",
        "refseq_ac": [
            {
                "id": "NP_001074239",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074239",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KIR2DL4; CD158D; KIR103AS; LOC112268354; LOC124900568",
        "gene_names_refseq": "CD158D; G9P; KIR-103AS; KIR-2DL4; KIR103AS; KIR103; KIR2DL4",
        "protein_names_uniprotkb": "Killer cell immunoglobulin-like receptor 2DL4; CD158 antigen-like family member D; G9P; KIR-103AS; Killer cell inhibitory receptor 103AS; MHC class I NK cell receptor KIR103AS",
        "protein_names_refseq": "CD158 antigen-like family member D; KIR2DL4 Killer-cell Immunoglobulin-like Receptor; KIR2DL4*00102; KIR2DL4*00103; KIR2DL4*00501; KIR2DL4*00801; KIR2DL4*00802; KIR2DL4*01101; KIR2DL4*021; KIR2DL4*022; KIR2DL4_00201 protein; KIR2DL4_00201; MHC class I NK cell receptor KIR103AS; killer cell immunoglobulin-like receptor 2DL4 isoform c precursor; killer cell immunoglobulin-like receptor 2DL4; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 4; killer cell inhibitory receptor 103AS",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3805);  (R-HSA-198933)",
        "pathway_count": 2,
        "publication_count": 99,
        "publication_id_list": "10190900;10499918;10746781;11237011;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12213321;12483297;12588680;14719373;14970179;15034010;15136729;15155468;15187158;15304001;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;16014749;16091383;16129954;16339513;16366734;16380601;16551255;16737824;16754721;16893496;16904340;16928187;17045824;17057721;17237375;17337780;18031695;18037897;18055229;18082267;18209062;18234675;18593354;18604210;19149696;19304799;19359216;19592130;20179272;20730098;21241660;21800138;21841309;21877119;22396535;23184984;23695528;23929856;24305946;25703557;25716998;26284469;26300885;29262349;29557506;31844290;32265295;35063466;35185887;35848898;36010968;36890645;37944995;7531291;7542404;8178173;8946682;8995416;9059894;9234477;9285412;9314561;9430220;9700512;9730896",
        "class_list": "",
        "function": "Clinical significance and immune landscape of KIR2DL4 and the senescence-based signature in cutaneous melanoma., [RefSeq, PubMed]; KIR2DL4 promotes the proliferation of RCC cell associated with PI3K/Akt signaling activation., [RefSeq, PubMed]; KIR2DL4/HLA-G polymorphisms were associated with HCV infection susceptibility among Chinese high-risk population., [RefSeq, PubMed]; Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. This gene is one of the 'framework' loci that is present on all haplotypes. Alternate alleles of this gene are represented on multiple alternate reference loci (ALT_REF_LOCs). Alternative splicing results in multiple transcript variants, some of which may not be annotated on the primary reference assembly. [provided by RefSeq, Jul 2016]., [RefSeq]; Receptor for non-classical major histocompatibility class Ib HLA-G molecules. Recognizes HLA-G in complex with B2M/beta-2 microglobulin and a nonamer self-peptide (peptide-bound HLA-G-B2M). In decidual NK cells, binds peptide-bound HLA-G-B2M complex and triggers NK cell senescence-associated secretory phenotype as a molecular switch to promote vascular remodeling and fetal growth in early pregnancy (PubMed:16366734, PubMed:23184984, PubMed:29262349). May play a role in balancing tolerance and antiviral-immunity at maternal-fetal interface by keeping in check the effector functions of NK, CD8+ T cells and B cells (PubMed:10190900, PubMed:16366734). Upon interaction with peptide-bound HLA-G-B2M, initiates signaling from the endosomal compartment leading to downstream activation of PRKDC-XRCC5 and AKT1, and ultimately triggering NF-kappa-B-dependent pro-inflammatory response (PubMed:20179272)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Roles of HLA-G/KIR2DL4 in Breast Cancer Immune Microenvironment. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Underrepresentation of activating KIR gene expression in single-cell RNA-seq data is due to KIR gene misassignment., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8W795;O14621;O14622;O14623;O14624;O43534;P78400;P78401;Q8N738;Q99559;Q99560;Q99561;Q99562;Q9UQJ7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0032394 MHC class Ib receptor activity;GO:0004888 transmembrane signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031901 early endosome membrane",
        "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0007165 signal transduction;GO:0006968 cellular defense response;GO:0045953 negative regulation of natural killer cell mediated cytotoxicity;GO:2000774 positive regulation of cellular senescence",
        "synthesized_glycan_count": 0,
        "hit_score": 10.1,
        "record_id": "Q99706-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1000000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZN17-1",
        "uniprot_id": [
            {
                "id": "LN28B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZN17",
                "type": "external"
            }
        ],
        "mass": 27084.0,
        "length": 250,
        "protein_name": "Protein lin-28 homolog B",
        "gene_name": "LIN28B",
        "organism": "Human",
        "refseq_name": "protein lin-28 homolog B isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001004317",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004317",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LIN28B; CSDD2",
        "gene_names_refseq": "CSDD2; LIN28B",
        "protein_names_uniprotkb": "Protein lin-28 homolog B; Lin-28B",
        "protein_names_refseq": "Lin-28.2; lin-28B; protein lin-28 homolog B isoform 1; protein lin-28 homolog B",
        "tax_id": 9606,
        "disease": "neuroblastoma (Disease Ontology:DOID:769)",
        "pathway": " (hsa:389421)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;16971064;18951094;19211792;19413330;19483683;19651622;19664994;19703396;22118463;22570413;23186163;30379171;33107691;35051231;37217939;38305285;38321106;38338881;38612395;38704454",
        "class_list": "",
        "function": "A Multi-Omics Approach Reveals Enrichment in Metabolites Involved in the Regulation of the Glutathione Pathway in LIN28B-Dependent Cancer Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Highlight an important role for Lin-28B in Myc-driven cellular phenotypes, [RefSeq, PubMed]; LIN28B promotes differentiation of fully transformed AML cells but is dispensable for fetal leukemia suppression., [RefSeq, PubMed]; MIR222HG/LIN28B/ATG5 Axis Drives M2 Macrophage Polarization and Proliferation of Hepatocellular Carcinoma Cells., [RefSeq, PubMed]; Regulating Protein-RNA Interactions: Advances in Targeting the LIN28/Let-7 Pathway. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA (PubMed:22118463). Does not act on pri-miR21 (PubMed:22118463). The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation (PubMed:19703396). This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent (PubMed:22118463). Interaction with target pre-miRNAs occurs via an 5'-GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let-7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; The protein encoded by this gene belongs to the lin-28 family, which is characterized by the presence of a cold-shock domain and a pair of CCHC zinc finger domains. This gene is highly expressed in testis, fetal liver, placenta, and in primary human tumors and cancer cell lines. It is negatively regulated by microRNAs that target sites in the 3' UTR, and overexpression of this gene in primary tumors is linked to the repression of let-7 family of microRNAs and derepression of let-7 targets, which facilitates cellular transformation. [provided by RefSeq, Jun 2012]., [RefSeq]; These findings strongly implicate a critical role of LIN28B during development and tumorigenesis and suggest a possible novel mechanism., [RefSeq, PubMed]; Transcriptional repression of the oncofetal LIN28B gene by the transcription factor SOX6. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 1,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L165;B2RPN6;Q5TCM4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0050779 RNA destabilization;GO:2000635 negative regulation of primary miRNA processing;GO:0031054 pre-miRNA processing;GO:2000627 positive regulation of miRNA catabolic process;GO:2000632 negative regulation of pre-miRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q6ZN17-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14662-1",
        "uniprot_id": [
            {
                "id": "STX16_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14662",
                "type": "external"
            }
        ],
        "mass": 37031.0,
        "length": 325,
        "protein_name": "Syntaxin-16",
        "gene_name": "STX16",
        "organism": "Human",
        "refseq_name": "syntaxin-16 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001001433",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001433",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "STX16",
        "gene_names_refseq": "STX16; SYN-16; SYN16",
        "protein_names_uniprotkb": "Syntaxin-16; Syn16",
        "protein_names_refseq": "syntaxin-16 isoform a",
        "tax_id": 9606,
        "disease": "pseudohypoparathyroidism type 1B (Disease Ontology:DOID:0080222)",
        "pathway": " (hsa:8675);  (R-HSA-6811438);  (R-HSA-6811440)",
        "pathway_count": 3,
        "publication_count": 158,
        "publication_id_list": "10189370;10209123;10445031;10559959;10637310;10652308;10652516;10865125;10990452;11237011;11303027;11346801;11359012;11689439;11718716;11748249;11827983;11839770;12011112;12070132;12377769;12383348;12429822;12620188;12620189;14561710;14580338;14718928;15029241;15037235;15077113;15077114;15128430;15269279;15483056;15504911;15654769;15718469;15728195;15758030;15800843;15870108;15878329;16042553;16129887;16571679;16885419;16912714;16936697;17274799;17451557;17488291;17562788;17684057;17698061;17852734;18086915;18195106;18243103;18256213;18367545;18451304;18578522;18664496;18946081;19164740;19490898;19536132;19620288;19715559;20068231;20163571;20166139;20685960;20874812;21183348;21421921;21436057;21689688;21807881;22013193;22188167;22299025;22335553;22354037;22581368;22717455;23091056;23239882;23378023;23437303;23462996;23839779;23936529;23940353;24119662;24794632;25343031;25576301;25708460;28467828;28626000;28649982;28832583;28834231;28855257;28904123;29242379;29314611;29393594;29557506;29632046;30315122;30573663;31020640;31844290;31848261;32157095;32350084;32357974;32387766;32938616;32983136;33043033;33091337;33141586;33298915;33592498;33912179;33936100;33968037;34357683;34477200;34509645;35051231;35132862;35154160;36010968;38095637;7909812;8221884;8440258;8620540;8636227;8670882;8945478;9050864;9177194;9230071;9244307;9464276;9476900;9510256;9587053;9590177;9653114;9707577;9915833",
        "class_list": "",
        "function": "Intrafamilial phenotypic heterogeneity in siblings with pseudohypoparathyroidism 1B due to maternal STX16 deletion. Publication Status: Online-Only, [RefSeq, PubMed]; Progression of PTH Resistance in Autosomal Dominant Pseudohypoparathyroidism Type Ib Due to Maternal STX16 Deletions., [RefSeq, PubMed]; SNARE involved in vesicular transport from the late endosomes to the trans-Golgi network., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Syntaxin 16 may thus play a role in neurite outgrowth and perhaps other specific dendritic anterograde/retrograde traffic., [RefSeq, PubMed]; This gene encodes a protein that is a member of the syntaxin or t-SNARE (target-SNAP receptor) family. These proteins are found on cell membranes and serve as the targets for V-SNARES (vesicle-SNAP receptors) permitting specific synaptic vesicle docking and fusion. A microdeletion in the region of chromosome 20 where this gene is located has been associated with pseudohypoparathyroidism type Ib. Multiple transcript variants have been found for this gene. Read-through transcription also exists between this gene and the neighboring downstream aminopeptidase-like 1 (NPEPL1) gene. [provided by RefSeq, Mar 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NK32;A6NN69;A8MPP0;B7ZBN1;B7ZBN2;B7ZBN3;E1P5M0;E1P607;O14661;O14663;O60517;Q5W084;Q5W086;Q5W087;Q5XKI6;Q6GMS8;Q9H0Z0;Q9H1T7;Q9H1T8;Q9UIX5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019905 syntaxin binding;GO:0000149 SNARE binding;GO:0005484 SNAP receptor activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0005925 focal adhesion",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling;GO:0006906 vesicle fusion;GO:0048278 vesicle docking",
        "synthesized_glycan_count": 0,
        "hit_score": 16.1,
        "record_id": "O14662-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N653-1",
        "uniprot_id": [
            {
                "id": "LZTR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N653",
                "type": "external"
            }
        ],
        "mass": 94719.0,
        "length": 840,
        "protein_name": "Leucine-zipper-like transcriptional regulator 1",
        "gene_name": "LZTR1",
        "organism": "Human",
        "refseq_name": "leucine-zipper-like transcriptional regulator 1",
        "refseq_ac": [
            {
                "id": "NP_006758",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006758",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LZTR1; TCFL2",
        "gene_names_refseq": "BTBD29; LZTR-1; LZTR1; NS10; NS2; SWNTS2",
        "protein_names_uniprotkb": "Leucine-zipper-like transcriptional regulator 1; LZTR-1",
        "protein_names_refseq": "epididymis secretory sperm binding protein; leucine zipper like transcription regulator 1; leucine-zipper-like transcriptional regulator 1",
        "tax_id": 9606,
        "disease": "Noonan syndrome 2 (Disease Ontology:DOID:0060580); Noonan syndrome 10 (Disease Ontology:DOID:0060588); schwannomatosis 2 (Disease Ontology:DOID:0070481); stomach cancer (Disease Ontology:DOID:10534); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); neurilemmoma (Disease Ontology:DOID:3192); schwannomatosis (Disease Ontology:DOID:3204); Noonan syndrome (Disease Ontology:DOID:3490); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:8216)",
        "pathway_count": 1,
        "publication_count": 72,
        "publication_id_list": "11237011;16356934;18477386;23481700;24362817;24715725;25335493;25480913;25576301;25645385;25795793;25880248;25892735;26154972;26992070;27846572;27862975;27920218;28218747;28649982;28832583;28834231;28904123;29242379;29393594;29437277;29469822;29493099;29557506;29632046;29769354;29786170;29789417;29959388;30315122;30368668;30429286;30442762;30442766;30481304;30779550;31154438;31217245;31844290;31848261;32157095;32161166;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33912179;33936100;33968037;33981976;34561969;34626534;34932366;35051231;35580925;36010968;37592023;37936555;37938771;38453365;39003740;40934300;7633402",
        "class_list": "",
        "function": "Exome sequencing identifies breast cancer susceptibility genes and defines the contribution of coding variants to breast cancer risk. Erratum:[Nat Genet. 2023 Nov;55(11):2009. doi: 10.1038/s41588-023-01549-x. PMID: 37752376], [RefSeq, PubMed]; LZTR-1 is the first BTB-kelch protein that exclusively localizes to the Golgi network, [RefSeq, PubMed]; Mutation-induced LZTR1 polymerization provokes cardiac pathology in recessive Noonan syndrome., [RefSeq, PubMed]; Oncogenic mutations of KRAS modulate its turnover by the CUL3/LZTR1 E3 ligase complex. Publication Status: Online-Only, [RefSeq, PubMed]; Prenatal diagnosis of autosomal recessive Noonan syndrome associated with biallelic LZTR1 variants presented with thick nuchal translucency and cardiac abnormalities., [RefSeq, PubMed]; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin-protein ligase complex that mediates ubiquitination of Ras (K-Ras/KRAS, N-Ras/NRAS and H-Ras/HRAS). Is a negative regulator of RAS-MAPK signaling that acts by controlling Ras levels and decreasing Ras association with membranes., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of the BTB-kelch superfamily. Initially described as a putative transcriptional regulator based on weak homology to members of the basic leucine zipper-like family, the encoded protein subsequently has been shown to localize exclusively to the Golgi network where it may help stabilize the Gogli complex. Deletion of this gene may be associated with DiGeorge syndrome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 11,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14776;Q20WK0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0031267 small GTPase binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0012505 endomembrane system;GO:0055038 recycling endosome membrane;GO:0031463 Cul3-RING ubiquitin ligase complex;GO:0055037 recycling endosome",
        "go_biological_process": "GO:0046580 negative regulation of Ras protein signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "Q8N653-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WXG6-1",
        "uniprot_id": [
            {
                "id": "MADD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WXG6",
                "type": "external"
            }
        ],
        "mass": 183303.0,
        "length": 1647,
        "protein_name": "MAP kinase-activating death domain protein",
        "gene_name": "MADD",
        "organism": "Human",
        "refseq_name": "MAP kinase-activating death domain protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_569826",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_569826",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MADD; DENN; IG20; KIAA0358",
        "gene_names_refseq": "DEEAH; DENN; IG20; MADD; NEDDISH; RAB3GEP; RabGEF",
        "protein_names_uniprotkb": "MAP kinase-activating death domain protein; Differentially expressed in normal and neoplastic cells; Insulinoma glucagonoma clone 20; Rab3 GDP/GTP exchange factor; Rab3 GDP/GTP exchange protein; Rab3GEP; RabGEF",
        "protein_names_refseq": "Insuloma-Glucagonoma protein 20; MAP kinase-activating death domain protein isoform 1; MAP kinase-activating death domain protein; Rab3 GDP/GTP exchange factor; differentially expressed in normal and neoplastic cells; insulinoma glucagonoma clone 20; rab3 GDP/GTP exchange protein",
        "tax_id": 9606,
        "disease": "alcohol use disorder (Disease Ontology:DOID:1574); transient cerebral ischemia (Disease Ontology:DOID:224); type 2 diabetes mellitus (Disease Ontology:DOID:9352); deeah syndrome (MONDO:MONDO:0033561); neurodevelopmental disorder with dysmorphic facies, impaired speech, and hypotonia (MONDO:MONDO:0033562)",
        "pathway": " (hsa:8567)",
        "pathway_count": 1,
        "publication_count": 108,
        "publication_id_list": "10.1101/2023.09.13.557529;10825539;11237011;11577081;14716293;16959763;18452278;18559336;18669648;18691976;19415658;19651622;19664994;20058876;20068231;20937701;22424782;22898188;23186163;23481700;24715725;25576301;25645385;25880248;25892735;26154972;26992070;27543614;27600516;27862975;28121444;28218747;28228285;28514659;28649982;28657654;28832583;28834231;28904123;28940097;29242379;29288388;29351928;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30429286;30524438;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32761064;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33592498;33633747;33691108;33717175;33723354;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34405274;34509645;34551092;34561969;34932366;35051231;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37932938;37938771;38459224;38506245;38838015;39534244;40914422;8988362;9115275;9796103",
        "class_list": "",
        "function": "Calloso-adreno-scrotal agenesis associated with biallelic MAPK-activating death domain protein (MADD) variant: Further phenotypic delineation of MADD deficiency., [RefSeq, PubMed]; GDP/GTP exchange factor MADD drives activation and recruitment of secretory Rab GTPases to Weibel-Palade bodies., [RefSeq, PubMed]; Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms (PubMed:18559336, PubMed:20937701). Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion (By similarity). Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction (By similarity). Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses (By similarity). Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals (By similarity). Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2 (PubMed:32761064). May link TNFRSF1A with MAP kinase activation (PubMed:9115275). May be involved in the regulation of TNFA-induced apoptosis (PubMed:11577081, PubMed:32761064)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Guanyl-nucleotide exchange factor that regulates small GTPases of the Rab family. Converts GDP-bound inactive form of RAB27A and RAB27B to the GTP-bound active forms. Converts GDP-bound inactive form of RAB3A, RAB3C and RAB3D to the GTP-bound active forms, GTPases involved in synaptic vesicle exocytosis and vesicle secretion. Plays a role in synaptic vesicle formation and in vesicle trafficking at the neuromuscular junction. Involved in up-regulating a post-docking step of synaptic exocytosis in central synapses. Probably by binding to the motor proteins KIF1B and KIF1A, mediates motor-dependent transport of GTP-RAB3A-positive vesicles to the presynaptic nerve terminals. Plays a role in TNFA-mediated activation of the MAPK pathway, including ERK1/2. May link TNFRSF1A with MAP kinase activation. May be involved in the regulation of TNFA-induced apoptosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Homozygous variant in MADD, encoding a Rab guanine nucleotide exchange factor, results in pleiotropic effects and a multisystemic disorder., [RefSeq, PubMed]; MADD regulates natural killer cell degranulation through Rab27a activation., [RefSeq, PubMed]; New insights into the clinical and molecular spectrum of the MADD-related neurodevelopmental disorder., [RefSeq, PubMed]; Tumor necrosis factor alpha (TNF-alpha) is a signaling molecule that interacts with one of two receptors on cells targeted for apoptosis. The apoptotic signal is transduced inside these cells by cytoplasmic adaptor proteins. The protein encoded by this gene is a death domain-containing adaptor protein that interacts with the death domain of TNF-alpha receptor 1 to activate mitogen-activated protein kinase (MAPK) and propagate the apoptotic signal. It is membrane-bound and expressed at a higher level in neoplastic cells than in normal cells. Several transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 2,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 25,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 53,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 5,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8S7;B5MEE5;D3DQR4;O15065;O15293;Q15732;Q15741;Q8IWD7;Q8WXG3;Q8WXG4;Q8WXG5;Q8WZ63",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0005123 death receptor binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon",
        "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0007166 cell surface receptor signaling pathway;GO:0043410 positive regulation of MAPK cascade;GO:0097194 execution phase of apoptosis;GO:2001236 regulation of extrinsic apoptotic signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "Q8WXG6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6DN14-1",
        "uniprot_id": [
            {
                "id": "MCTP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6DN14",
                "type": "external"
            }
        ],
        "mass": 111624.0,
        "length": 999,
        "protein_name": "Multiple C2 and transmembrane domain-containing protein 1",
        "gene_name": "MCTP1",
        "organism": "Human",
        "refseq_name": "multiple C2 and transmembrane domain-containing protein 1 isoform S",
        "refseq_ac": [
            {
                "id": "NP_001002796",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002796",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MCTP1",
        "gene_names_refseq": "MCTP1",
        "protein_names_uniprotkb": "Multiple C2 and transmembrane domain-containing protein 1",
        "protein_names_refseq": "multiple C2 and transmembrane domain-containing protein 1 isoform S; multiple C2 and transmembrane domain-containing protein 1; multiple C2 domains, transmembrane 1; multiple C2-domains with two transmembrane regions 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79772)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "11237011;15528213;18510355;20934997;22424782;22544926;23481700;24366607;24715725;26154972;26195140;27600516;27846572;27920218;28040410;28228285;28832583;28834231;28904123;29242379;29393594;29557506;29786170;31844290;32357974;32387766;32502341;33141586;33392160;33571139;33826368;38861615",
        "class_list": "",
        "function": "Calcium sensor which is essential for the stabilization of normal baseline neurotransmitter release and for the induction and long-term maintenance of presynaptic homeostatic plasticity., [UniProtKB, UniProtKB]; MCTP1 increases the malignancy of androgen-deprived prostate cancer cells by inducing neuroendocrine differentiation and EMT., [RefSeq, PubMed]; MCTP1 was observed on synaptic vesicles in neuronal cell bodies and pre-synaptic axon terminals., [RefSeq, PubMed]; MCTPs are evolutionarily conserved C2 domain proteins that are unusual in that the C2 domains are anchored in the membrane by two closely spaced transmembrane regions and represent Ca(2+)-binding but not phospholipid-binding modules, [RefSeq, PubMed]; Multiple C2 domain-containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains., [RefSeq, PubMed]; The DNA methylation-regulated MCTP1 activates the drug-resistance of esophageal cancer cells., [RefSeq, PubMed]; This Gene-based tests suggest evidence of association with related genes, ZEB2, RND3, MCTP1, CTBP2, and beta EEG., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6DN13;Q8N2W1;Q8NBA2;Q96LX0;Q9H6E8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0016020 membrane;GO:0055037 recycling endosome;GO:0005789 endoplasmic reticulum membrane;GO:0030672 synaptic vesicle membrane",
        "go_biological_process": "GO:0045806 negative regulation of endocytosis;GO:0019722 calcium-mediated signaling;GO:0030336 negative regulation of cell migration;GO:0046928 regulation of neurotransmitter secretion;GO:0048168 regulation of neuronal synaptic plasticity",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q6DN14-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99638-1",
        "uniprot_id": [
            {
                "id": "RAD9A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99638",
                "type": "external"
            }
        ],
        "mass": 42547.0,
        "length": 391,
        "protein_name": "Cell cycle checkpoint control protein RAD9A",
        "gene_name": "RAD9A",
        "organism": "Human",
        "refseq_name": "cell cycle checkpoint control protein RAD9A isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001230153",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230153",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAD9A",
        "gene_names_refseq": "RAD9A; RAD9",
        "protein_names_uniprotkb": "Cell cycle checkpoint control protein RAD9A; 3.1.11.2; DNA repair exonuclease rad9 homolog A; hRAD9",
        "protein_names_refseq": "DNA repair exonuclease rad9 homolog A; RAD9 homolog A; cell cycle checkpoint control protein RAD9A isoform 2; cell cycle checkpoint control protein RAD9A; hRAD9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5883);  (R-HSA-176187);  (R-HSA-5685938);  (R-HSA-5693607);  (R-HSA-5693616);  (R-HSA-6804756);  (R-HSA-69473);  (R-HSA-9709570)",
        "pathway_count": 8,
        "publication_count": 235,
        "publication_id_list": "10051570;10212258;10359610;10373362;10373512;10435622;10438626;10500146;10551859;10570149;10570174;10604467;10673500;10673501;10710310;10713044;10733923;10744977;10777662;10827953;10846170;10859164;10884347;10884395;10921897;11080452;11139606;11237011;11239457;11278446;11301010;11376695;11390642;11447225;11511362;11546806;11551919;11551930;11571269;11573955;11698410;11740489;11751635;11780126;11832208;11971963;12064478;12139939;12152085;12191481;12226092;12228710;12370410;12379650;12393879;12399544;12545175;12578958;12628935;12676583;12676925;12702766;12709442;12734188;12750383;12759351;12791985;12851404;12914926;12963847;14500360;14576433;14603323;14605214;14624239;14702041;14734547;15053879;15189136;15190204;15226314;15314187;15359272;15485900;15556996;15665856;15703751;15707391;15743907;15833913;15866171;15871698;15897895;16148040;16153896;16216273;16322561;16327781;16360315;16407120;16530042;16885023;17081983;17108107;17322306;17349958;17511890;17515903;17575048;17591690;17928296;17962301;17965729;18171670;18317453;18480045;18490454;18539610;18541667;18669648;18757400;18769057;18805091;18923075;18940270;18971343;19121998;19357644;19413330;19419957;19651622;19690332;19965871;20068231;20154705;20233725;20545769;20724438;20729832;20729858;20729859;20858457;20959462;20965415;21052091;21240188;21263215;21317932;21325134;21335604;21406692;21565612;21659603;21680713;21777809;21804533;22021381;22024395;22194698;22231403;22635276;22661229;22661230;22792074;22925454;22977173;23000554;23028682;23149936;23186163;23345434;23468639;23485397;23676219;23810717;23946870;24013206;24098381;24145406;24376897;24715725;24874608;25091155;25113031;25122754;25558984;25576301;25645385;25659039;26145171;26658951;26860083;27188607;28228285;28904123;29242379;29254517;29557506;29786170;30295604;30779550;31135337;31776186;31844290;32157095;32161166;32357974;32387766;32897882;32938616;33298915;33392160;33912179;33968037;33978741;34087483;34440403;34509645;35051231;36010968;36172813;36241641;36580660;36841485;38354779;39116498;39894887;8196638;8702565;8943031;9278511;9278512;9705271;9837724;9925639",
        "class_list": "",
        "function": "Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair (PubMed:10713044, PubMed:17575048, PubMed:20545769, PubMed:21659603, PubMed:31135337). The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex (PubMed:21659603). Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER) (PubMed:21659603). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates (PubMed:21659603). The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase (PubMed:21659603). RAD9A possesses 3'->5' double stranded DNA exonuclease activity (PubMed:10713044)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Component of the 9-1-1 cell-cycle checkpoint response complex that plays a major role in DNA repair. The 9-1-1 complex is recruited to DNA lesion upon damage by the RAD17-replication factor C (RFC) clamp loader complex. Acts then as a sliding clamp platform on DNA for several proteins involved in long-patch base excision repair (LP-BER). The 9-1-1 complex stimulates DNA polymerase beta (POLB) activity by increasing its affinity for the 3'-OH end of the primer-template and stabilizes POLB to those sites where LP-BER proceeds; endonuclease FEN1 cleavage activity on substrates with double, nick, or gap flaps of distinct sequences and lengths; and DNA ligase I (LIG1) on long-patch base excision repair substrates. The 9-1-1 complex is necessary for the recruitment of RHNO1 to sites of double-stranded breaks (DSB) occurring during the S phase. RAD9A possesses 3'->5' double stranded DNA exonuclease activity., [UniProtKB, UniProtKB, UniProtKB]; Structural basis for intra- and intermolecular interactions on RAD9 subunit of 9-1-1 checkpoint clamp implies functional 9-1-1 regulation by RHINO., [RefSeq, PubMed]; This gene product is highly similar to Schizosaccharomyces pombe rad9, a cell cycle checkpoint protein required for cell cycle arrest and DNA damage repair. This protein possesses 3' to 5' exonuclease activity, which may contribute to its role in sensing and repairing DNA damage. It forms a checkpoint protein complex with RAD1 and HUS1. This complex is recruited by checkpoint protein RAD17 to the sites of DNA damage, which is thought to be important for triggering the checkpoint-signaling cascade. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]., [RefSeq]; Unveiling an anoikis-related risk model and the role of RAD9A in colon cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
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        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 25,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCZ8;Q6FI29;Q96C41",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "6.5.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "5.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.1",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.11.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.2",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008296 3'-5'-DNA exonuclease activity;GO:0017124 SH3 domain binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0042826 histone deacetylase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0030896 checkpoint clamp complex",
        "go_biological_process": "GO:0000076 DNA replication checkpoint signaling;GO:0006281 DNA repair;GO:0006974 DNA damage response;GO:0071479 cellular response to ionizing radiation;GO:0031573 mitotic intra-S DNA damage checkpoint signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 23.8,
        "record_id": "Q99638-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43896-1",
        "uniprot_id": [
            {
                "id": "KIF1C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43896",
                "type": "external"
            }
        ],
        "mass": 122947.0,
        "length": 1103,
        "protein_name": "Kinesin-like protein KIF1C",
        "gene_name": "KIF1C",
        "organism": "Human",
        "refseq_name": "kinesin-like protein KIF1C",
        "refseq_ac": [
            {
                "id": "NP_006603",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006603",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KIF1C; KIAA0706",
        "gene_names_refseq": "KIF1C; LTXS1; SATX2; SAX2; SPAX2; SPG58",
        "protein_names_uniprotkb": "Kinesin-like protein KIF1C",
        "protein_names_refseq": "kinesin-like protein KIF1C; spastic ataxia 2 (autosomal recessive)",
        "tax_id": 9606,
        "disease": "spastic ataxia 2 (Disease Ontology:DOID:0050941); nervous system disease (Disease Ontology:DOID:863)",
        "pathway": " (hsa:10749);  (R-HSA-6811434);  (R-HSA-983189)",
        "pathway_count": 3,
        "publication_count": 174,
        "publication_id_list": "10052452;10318838;10445031;10559254;10559959;10761932;10921873;11172815;11237011;11493604;11689559;11703931;11726511;11739780;11748249;11782313;12047556;12070132;12368902;1406973;14504276;14654841;15029241;15037235;15272311;15326200;15616190;15632110;15813748;16030262;1607388;16262723;1631136;16554367;16571679;16633337;1680566;16912714;16926190;16940185;16964243;17081983;17113389;17253781;17346968;17360540;17429068;17451557;17538014;17760859;17927562;17956946;18182008;18287528;18342609;18524849;18669648;18809720;1898986;19015319;19109418;19116309;19151722;19164740;19338388;19369418;19413330;1957170;19631211;19651622;19664994;19690332;19758564;20005805;20068231;20136777;20357002;20427317;20462495;20534429;20637885;21219331;21406692;2142332;21550981;21689688;21844168;22013193;22094269;22304919;23186163;23396477;23481700;24129315;24275569;24319291;24482476;2521221;2522352;25364732;25436559;25492864;25576301;25645385;27846572;27862975;27920218;28218747;28832583;28904123;29242379;29393594;29557506;29632046;30429286;30779550;31092671;31154438;3130248;3134048;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32350084;32387766;32488085;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33968037;34171305;34932366;35051231;35318648;35580925;35961316;36010968;36099894;36215666;36241641;36284347;38253038;38726004;7528108;7539720;7822426;7844144;7929562;8001155;8128252;8132710;8221884;8253837;8505331;8548803;8599929;8602245;8620540;9114004;9177194;9244307;9288971;9405360;9685376;9751720;9990005",
        "class_list": "",
        "function": "Force generation of KIF1C is impaired by pathogenic mutations., [RefSeq, PubMed]; Hairpin RNA-based depletion of KIF1C resulted in decreased podosome dynamics and ultimately in podosome deficiency., [RefSeq, PubMed]; Intracellular transport: KIF1C produces force along with a few slips., [RefSeq, PubMed]; KIF1C and new Huntingtin-interacting protein 1 binding proteins regulate rheumatoid arthritis fibroblast-like synoviocytes' phenotypes. Publication Status: Online-Only, [RefSeq, PubMed]; Motor required for the retrograde transport of Golgi vesicles to the endoplasmic reticulum. Has a microtubule plus end-directed motility., [UniProtKB, PubMed]; The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. Mutations in this gene are a cause of spastic ataxia 2, autosomal recessive. [provided by RefSeq, May 2014]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DTL6;O75186;Q5U618",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0008574 plus-end-directed microtubule motor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005874 microtubule;GO:0030424 axon",
        "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:1990048 anterograde neuronal dense core vesicle transport;GO:1990049 retrograde neuronal dense core vesicle transport;GO:0007018 microtubule-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 17.7,
        "record_id": "O43896-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16849-1",
        "uniprot_id": [
            {
                "id": "PTPRN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16849",
                "type": "external"
            }
        ],
        "mass": 105848.0,
        "length": 979,
        "protein_name": "Receptor-type tyrosine-protein phosphatase-like N",
        "gene_name": "PTPRN",
        "organism": "Human",
        "refseq_name": "receptor-type tyrosine-protein phosphatase-like N isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001186692",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186692",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTPRN; ICA3; ICA512",
        "gene_names_refseq": "IA-2/PTP; IA-2; IA2; ICA512; PTPRN; R-PTP-N",
        "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase-like N; ICA 512; Islet cell antigen 512; Islet cell autoantigen 3; PTP IA-2; R-PTP-N",
        "protein_names_refseq": "ICA 512; PTP IA-2; insulinoma-associated tyrosine-phosphatase-like protein; islet cell antigen 2; islet cell antigen 512; islet cell autoantigen 3; protein tyrosine phosphatase-like N; receptor-type tyrosine-protein phosphatase-like N isoform 2 precursor",
        "tax_id": 9606,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:5798)",
        "pathway_count": 1,
        "publication_count": 61,
        "publication_id_list": "10457160;10562307;10867713;11091269;11237011;11358432;11483505;15596545;16273344;16503116;16622421;17065344;17513797;18048354;18058037;18178618;18305140;18390725;18824546;20083660;20886068;22171320;23234360;23803704;24714562;24715725;24843546;25249579;25561468;25992863;26718497;26836020;26944932;28794283;28904123;29196783;29429978;29557506;29851415;30078552;30428974;30626607;31154438;31457096;31844290;32157095;32157332;32928873;33298915;33592498;35040477;35051231;35263538;36010968;36284347;37074911;37938771;38253038;8024693;8144912;8641276",
        "class_list": "",
        "function": "Glutamic Acid Decarboxylase and Tyrosine Phosphatase-Related Islet Antigen-2 Positivity among Children and Adolescents with Diabetes in Korea., [RefSeq, PubMed]; ICA512-CCF translocated to the nucleus promotes expression of insulin and other granule-related genes; the function implicates binding to and regulating activity of STAT5B probably by preventing its dephosphorylation and potentially by inducing its sumoylation by recruiting PIAS4 (PubMed:15596545, PubMed:16622421, PubMed:18178618). Enhances pancreatic beta-cell proliferation by converging with signaling by STAT5B and STAT3 (PubMed:15596545, PubMed:16622421, PubMed:18178618). ICA512-CCF located in the cytoplasm regulates dynamics and exocytosis of insulin secretory granules (SGs) by dimerizing with ICA512-TMF and displacing SNTB2 thus enhancing SGs mobility and exocytosis (PubMed:18824546, PubMed:20886068)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; ICA512-TMF regulates dynamics and exocytosis of insulin secretory granules (SGs); binding of ICA512-TMF to SNTB2/beta-2-syntrophin is proposed to restrain SGs mobility and exocytosis by tethering them to the actin cytoskeleton depending on UTRN; the function is inhibited by cytoplasmic ICA512-CFF dimerizing with ICA512-TMF and displacing SNTB2., [UniProtKB, PubMed, PubMed]; Plays a role in vesicle-mediated secretory processes (PubMed:24843546). Required for normal accumulation of secretory vesicles in hippocampus, pituitary and pancreatic islets (By similarity). Required for the accumulation of normal levels of insulin-containing vesicles and preventing their degradation (PubMed:24843546). Plays a role in insulin secretion in response to glucose stimuli (PubMed:24843546). Required for normal accumulation of the neurotransmitters norepinephrine, dopamine and serotonin in the brain (By similarity). In females, but not in males, required for normal accumulation and secretion of pituitary hormones, such as luteinizing hormone (LH) and follicle-stimulating hormone (FSH) (By similarity). Required to maintain normal levels of renin expression and renin release (By similarity). Seems to lack intrinsic enzyme activity (By similarity). May regulate catalytic active protein-tyrosine phosphatases such as PTPRA through dimerization (By similarity)., [UniProtKB, UniProtKB, PubMed]; Seroreactivity Against Tyrosine Phosphatase PTPRN Links Type 2 Diabetes and Colorectal Cancer and Identifies a Potential Diagnostic and Therapeutic Target., [RefSeq, PubMed]; The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus (IDDM) patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 2,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 4,
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        "total_n_glycosites": 2,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 11,
        "disease_count": 3,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DK12;F5GZS3;Q08319;Q53QD6;Q6NSL1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008134 transcription factor binding;GO:0030507 spectrin binding;GO:0044389 ubiquitin-like protein ligase binding;GO:0004725 protein tyrosine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0030141 secretory granule",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0000302 response to reactive oxygen species;GO:0030073 insulin secretion;GO:0051046 regulation of secretion",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "Q16849-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P10620-1",
        "uniprot_id": [
            {
                "id": "MGST1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P10620",
                "type": "external"
            }
        ],
        "mass": 17599.0,
        "length": 155,
        "protein_name": "Microsomal glutathione S-transferase 1",
        "gene_name": "MGST1",
        "organism": "Human",
        "refseq_name": "microsomal glutathione S-transferase 1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001247440",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001247440",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MGST1; GST12; MGST",
        "gene_names_refseq": "GST12; MGST-I; MGST1; MGST; PMAN",
        "protein_names_uniprotkb": "Microsomal glutathione S-transferase 1; 2.5.1.18; Microsomal GST-1; Microsomal GST-I",
        "protein_names_refseq": "glutathione S-transferase 12; microsomal GST-1; microsomal GST-I; microsomal glutathione S-transferase 1 isoform a; peritoneal metastasis associated long noncoding RNA",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4257);  (R-HSA-156590);  (R-HSA-5423646);  (R-HSA-6798695)",
        "pathway_count": 4,
        "publication_count": 100,
        "publication_id_list": "10329152;10524215;10587441;10783391;11237011;11327815;11409944;11904223;12042665;12144777;12211029;12627223;12727802;12933810;14742434;1504254;16081649;16298388;16385575;1643250;16548513;16970545;18357469;18416522;19463;19615748;20083122;20085333;20112406;21106529;21668448;22522127;22645359;23162467;23650620;25418920;25469497;25576301;2573352;26992070;27846572;27862975;28510447;29557506;30484775;31217245;31844290;32157095;32325220;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33537174;33539732;33592498;3372534;33936100;33968037;33981976;34087483;34171305;34171541;34185709;34405274;34509645;34561969;35051231;35083852;35251023;35318648;35580925;36215666;36241641;36284347;37161854;37321450;3770744;37938771;38665916;3931076;4768551;7764673;7766804;8182750;8203914;8331657;8431482;8439558;8692836;8703034;8812420;8975785;9278457;9551553;9576847;9839448",
        "class_list": "",
        "function": "A role for microsomal glutathione transferase 1 in melanin biosynthesis and melanoma progression., [RefSeq, PubMed]; Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; MGST1 is a redox-sensitive repressor of ferroptosis in pancreatic cancer cells., [RefSeq, PubMed]; MiR-379-5p targets microsomal glutathione transferase 1 (MGST1) to regulate human glioma in cell proliferation, migration and invasion and epithelial-mesenchymal transition (EMT)., [RefSeq, PubMed]; Microsomal glutathione S-transferase 1 targets the autophagy signaling pathway to suppress ferroptosis in gastric carcinoma cells., [RefSeq, PubMed]; The MAPEG (Membrane Associated Proteins in Eicosanoid and Glutathione metabolism) family consists of six human proteins, two of which are involved in the production of leukotrienes and prostaglandin E, important mediators of inflammation. Other family members, demonstrating glutathione S-transferase and peroxidase activities, are involved in cellular defense against toxic, carcinogenic, and pharmacologically active electrophilic compounds. This gene encodes a protein that catalyzes the conjugation of glutathione to electrophiles and the reduction of lipid hydroperoxides. This protein is localized to the endoplasmic reticulum and outer mitochondrial membrane where it is thought to protect these membranes from oxidative stress. Several transcript variants, some non-protein coding and some protein coding, have been found for this gene. [provided by RefSeq, May 2012]., [RefSeq]",
        "predicted_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K533;G5EA53",
        "ec_number_list": [
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            },
            {
                "id": "3.2.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25",
                "type": "external"
            },
            {
                "id": "1.11.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-",
                "type": "external"
            },
            {
                "id": "4.4.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.4.1.20",
                "type": "external"
            },
            {
                "id": "2.5.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-",
                "type": "external"
            },
            {
                "id": "5.2.1.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.2",
                "type": "external"
            },
            {
                "id": "5.3.99.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.2",
                "type": "external"
            },
            {
                "id": "3.5.1.92",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "5.3.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.-",
                "type": "external"
            },
            {
                "id": "3.2.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20",
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            },
            {
                "id": "2.4.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-",
                "type": "external"
            },
            {
                "id": "2.4.1.275",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275",
                "type": "external"
            },
            {
                "id": "2.4.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22",
                "type": "external"
            },
            {
                "id": "2.4.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38",
                "type": "external"
            },
            {
                "id": "2.4.1.90",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.4.16.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2",
                "type": "external"
            },
            {
                "id": "3.4.23.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-",
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            },
            {
                "id": "1.20.4.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.20.4.2",
                "type": "external"
            },
            {
                "id": "1.8.5.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1",
                "type": "external"
            },
            {
                "id": "7.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67",
                "type": "external"
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            {
                "id": "2.3.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25",
                "type": "external"
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            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
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        ],
        "go_molecular_function": "GO:0004364 glutathione transferase activity;GO:0004602 glutathione peroxidase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005778 peroxisomal membrane;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0034635 glutathione transport;GO:0071449 cellular response to lipid hydroperoxide",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "P10620-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IUZ0-1",
        "uniprot_id": [
            {
                "id": "LRC49_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IUZ0",
                "type": "external"
            }
        ],
        "mass": 78894.0,
        "length": 686,
        "protein_name": "Leucine-rich repeat-containing protein 49",
        "gene_name": "LRRC49",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 49 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001185946",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185946",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC49; CSTPP2",
        "gene_names_refseq": "CSTPP2; LRRC49; PGs4",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 49; Centriolar satellite-associated tubulin polyglutamylase complex regulator 2; PGs4; Tubulin polyglutamylase complex subunit 4",
        "protein_names_refseq": "centriolar satellite-associated tubulin polyglutamylase complex regulator 2; centriolar satellite-associated tubulin polyglutamylation protein 2; leucine-rich repeat-containing protein 49 isoform 1; leucine-rich repeat-containing protein 49; polyglutamylase subunit 4; tubulin polyglutamylase complex subunit 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54839);  (R-HSA-8955332)",
        "pathway_count": 2,
        "publication_count": 33,
        "publication_id_list": "11237011;1520276;15890843;16901895;17244817;17244818;17360631;17499049;18331838;18575747;19524510;19531357;20519502;21074048;23358242;25103237;25468068;25957412;28218747;28832583;28834231;29146868;29437277;30315122;30429286;31844290;33592498;33691108;33912179;33968037;34782749;36215666;7452228",
        "class_list": "",
        "function": "Subunit of the tubulin polyglutamylase complex (TPGC). The complex mediates cilia and flagella polyglutamylation which is essential for their biogenesis and motility., [UniProtKB, PubMed]; Transcripts of LRRC49/THAP10 bidirectional gene pair are co-regulated by estrogen and that hypermethylation of the bidirectional promoter region simultaneously silences both genes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVX1;B7Z366;F5H1J4;G5E9T5;H0YLN4;Q9NXM6",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005874 microtubule;GO:0034451 centriolar satellite",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q8IUZ0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A5PL33-1",
        "uniprot_id": [
            {
                "id": "KRBD3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A5PL33",
                "type": "external"
            }
        ],
        "mass": 107498.0,
        "length": 1030,
        "protein_name": "KRAB domain-containing protein 3",
        "gene_name": "KRABD3",
        "organism": "Human",
        "refseq_name": "KRAB domain-containing protein 3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001277116",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001277116",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KRABD3; KIAA1862; KRBA1",
        "gene_names_refseq": "KRABD3; KRBA1",
        "protein_names_uniprotkb": "KRAB domain-containing protein 3; KRABD3",
        "protein_names_refseq": "KRAB domain-containing protein 3 isoform 2; KRAB domain-containing protein 3; KRAB-A domain containing 1; protein KRBA1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84626);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 38,
        "publication_id_list": "10235266;10330177;11237011;11395415;14519192;15175151;15896744;16606702;16719718;19664994;19690332;2163759;23186163;23481700;26811146;26992070;27846572;27920218;28228285;29242379;30315122;31844290;32157095;32387766;32938616;33392160;33592498;33912179;33968037;34171305;34509645;35051231;35580925;36010968;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
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        "total_reported_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7E2F5;E7ENE9;Q8N4X0;Q96JG5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "A5PL33-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H2W1-1",
        "uniprot_id": [
            {
                "id": "M4A6A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H2W1",
                "type": "external"
            }
        ],
        "mass": 26943.0,
        "length": 248,
        "protein_name": "Membrane-spanning 4-domains subfamily A member 6A",
        "gene_name": "MS4A6A",
        "organism": "Human",
        "refseq_name": "membrane-spanning 4-domains subfamily A member 6A isoform 4",
        "refseq_ac": [
            {
                "id": "NP_001234928",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001234928",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MS4A6A; 4SPAN3; CD20L3; CDA01; MS4A6; MSTP090",
        "gene_names_refseq": "4SPAN3.2; 4SPAN3; CD20L3; CDA01; MS4A6A; MS4A6; MST090; MSTP090",
        "protein_names_uniprotkb": "Membrane-spanning 4-domains subfamily A member 6A; CD20 antigen-like 3; Four-span transmembrane protein 3",
        "protein_names_refseq": "CD20 antigen-like 3; CD20-like precusor; HAIRB-iso; MS4A6A-polymorph; four-span transmembrane protein 3.1; four-span transmembrane protein 3.2; membrane-spanning 4-domains subfamily A member 6A isoform 4; membrane-spanning 4-domains subfamily A member 6A; membrane-spanning 4-domains, subfamily A, member 6A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64231)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;11245982;11401424;11486273;21460840;22382309;23481700;27452731;29242379;29504051;29557506;31154438;32387766;32983136;33392160;35051231;35580925;36284347;36424895;37938771;38488530",
        "class_list": "",
        "function": "ABCA7 and the MS4A6A/MS4A4E gene cluster are new Alzheimer's disease susceptibility loci., [RefSeq, PubMed]; Data revealed the allele (T) of the rs3865444 polymorphism of the CD33 gene and the allele (C) of the rs610932 polymorphism of the MS4A6A gene may contribute to Alzheimer's disease risk in the Chinese Han population, [RefSeq, PubMed]; Identification of redundancy between human FcepsilonRIbeta and MS4A6A proteins points toward additional complex mechanisms for FcepsilonRI trafficking and signaling., [RefSeq, PubMed]; Involvement of microglia-expressed MS4A6A in the onset of glioblastoma., [RefSeq, PubMed]; May be involved in signal transduction as a component of a multimeric receptor complex., [UniProtKB]; Meta analysis validated the Alzheimer disease protective association for MS4A6A (rs610932) variants., [RefSeq, PubMed]; This gene encodes a member of the membrane-spanning 4A gene family. Members of this nascent protein family are characterized by common structural features and similar intron/exon splice boundaries and display unique expression patterns among hematopoietic cells and nonlymphoid tissues. The gene encoding this protein is localized to 11q12.1, among a cluster of family members. Alternative splicing of this gene results in several transcript variants that encode different protein isoforms. [provided by RefSeq, Oct 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "total_reported_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K755;F8W9K1;Q7Z4E8;Q8TBV7;Q8TEZ4;Q8TEZ5;Q96PG6;Q9H2L1;Q9H2N3;Q9H3V1;Q9HC76",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005802 trans-Golgi network;GO:0016020 membrane",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q9H2W1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y448-1",
        "uniprot_id": [
            {
                "id": "SKAP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y448",
                "type": "external"
            }
        ],
        "mass": 35438.0,
        "length": 316,
        "protein_name": "Small kinetochore-associated protein",
        "gene_name": "KNSTRN",
        "organism": "Human",
        "refseq_name": "small kinetochore-associated protein isoform b",
        "refseq_ac": [
            {
                "id": "NP_001136233",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136233",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KNSTRN; C15orf23; HSD11; SKAP; TRAF4AF1",
        "gene_names_refseq": "C15orf23; HSD11; KNSTRN; ROCHIS; SKAP; TRAF4AF1",
        "protein_names_uniprotkb": "Small kinetochore-associated protein; Kinastrin; Kinetochore-localized astrin-binding protein; Kinetochore-localized astrin/SPAG5-binding protein; SKAP; TRAF4-associated factor 1",
        "protein_names_refseq": "TRAF4 associated factor 1; kinastrin; kinetochore-localized astrin-binding protein; putative TRAF4-associated factor 1; small kinetochore associated protein; small kinetochore-associated protein isoform b; small kinetochore-associated protein, kinetochore-localized astrin-binding protein, TRAF4 associated factor 1",
        "tax_id": 9606,
        "disease": "skin squamous cell carcinoma (Disease Ontology:DOID:3151); actinic keratosis (Disease Ontology:DOID:8866); combined immunodeficiency with faciooculoskeletal anomalies (MONDO:MONDO:0013226)",
        "pathway": " (hsa:90417)",
        "pathway_count": 1,
        "publication_count": 69,
        "publication_id_list": "11237011;15855057;18691976;19667759;20068231;21402792;22110139;22965910;23035123;24366607;24714562;24715725;24718257;25194279;25418920;25576301;25892735;26154972;26728094;26992070;27600516;27846572;27920218;27982129;28218747;28832583;28834231;28904123;29180244;29242379;29393594;29508533;29557506;29671580;29786170;30315122;30833945;31222486;31530632;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33510346;33537174;33592498;33691108;33717175;33936100;33968037;34078123;34211107;34509645;34554241;34932366;35051231;35201967;35580925;36284347",
        "class_list": "",
        "function": "Essential component of the mitotic spindle required for faithful chromosome segregation and progression into anaphase (PubMed:19667759). Promotes the metaphase-to-anaphase transition and is required for chromosome alignment, normal timing of sister chromatid segregation, and maintenance of spindle pole architecture (PubMed:19667759, PubMed:22110139). The astrin (SPAG5)-kinastrin (SKAP) complex promotes stable microtubule-kinetochore attachments (PubMed:21402792). Required for kinetochore oscillations and dynamics of microtubule plus-ends during live cell mitosis, possibly by forming a link between spindle microtubule plus-ends and mitotic chromosomes to achieve faithful cell division (PubMed:23035123). May be involved in UV-induced apoptosis via its interaction with PRPF19; however, these results need additional evidences (PubMed:24718257)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Phosphorylation of small kinetochore-associated protein induced by GSK3beta promotes cell migration and invasion in esophageal cancer., [RefSeq, PubMed]; SKAP interacts with Aurora B to guide end-on capture of spindle microtubules via phase separation., [RefSeq, PubMed]; Src-mediated tyrosine phosphorylation of PRC1 and kinastrin/SKAP on the mitotic spindle. Publication Status: Online-Only, [RefSeq, PubMed]; This paper identifies role of gene product of FLJ14502, named SKAP in the paper, in mitosis. SKAP promotes metaphase-to-anaphase transition by mediating seperase activation after spindle assembly checkpoint is satisfied in mitosis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "predicted_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 8836,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DXA7;Q147U5;Q32Q57;Q5ISJ0;Q6P2S5;Q6PJM0;Q86XB4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0051010 microtubule plus-end binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005634 nucleus;GO:0005815 microtubule organizing center;GO:0000776 kinetochore;GO:0001726 ruffle",
        "go_biological_process": "GO:0007059 chromosome segregation;GO:0016477 cell migration;GO:0051301 cell division;GO:0051988 regulation of attachment of spindle microtubules to kinetochore;GO:0000226 microtubule cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "Q9Y448-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95232-1",
        "uniprot_id": [
            {
                "id": "LC7L3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95232",
                "type": "external"
            }
        ],
        "mass": 51466.0,
        "length": 432,
        "protein_name": "Luc7-like protein 3",
        "gene_name": "LUC7L3",
        "organism": "Human",
        "refseq_name": "luc7-like protein 3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_006098",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006098",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LUC7L3; CREAP1; CROP; O48",
        "gene_names_refseq": "CRA; CREAP-1; CROP; LUC7A; LUC7L3; OA48-18; hLuc7A",
        "protein_names_uniprotkb": "Luc7-like protein 3; CRE-associated protein 1; CREAP-1; Cisplatin resistance-associated-overexpressed protein; Luc7A; Okadaic acid-inducible phosphoprotein OA48-18; cAMP regulatory element-associated protein 1",
        "protein_names_refseq": "CRE-associated protein 1; LUC7-like 3; cAMP regulatory element-associated protein 1; cisplatin resistance-associated-overexpressed protein; luc7-like protein 3 isoform 1; luc7-like protein 3; okadaic acid-inducible phosphoprotein OA48-18",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51747);  (R-HSA-72163)",
        "pathway_count": 2,
        "publication_count": 142,
        "publication_id_list": "10631324;10754390;10882114;11014198;11101529;11233976;11237011;11991638;12176931;12411573;12414731;12477934;12565863;14625303;14713954;15798186;16314458;16462885;16809785;17095540;17322306;17332742;17525332;17606899;18077418;18322460;18452278;18593880;18663000;18669648;19103666;19165350;19413330;19415658;19536130;19574390;19608861;19651622;19664995;19690332;20068231;20423332;20980672;21406692;21536652;2176635;22110043;22223895;22365833;22959432;22961380;23186163;23222130;23236153;23345524;23604122;24196718;24304693;24448447;24715725;24737827;24914973;25114211;25555158;25576301;2558966;26154972;26385511;26420826;26969736;26992070;27377154;27459055;27683217;27846572;27920218;28062851;28076346;28502770;28510447;28589370;28781166;28832583;29242379;29301961;29360106;29361316;29393594;29493099;29512856;29557506;2963332;29786170;30315277;30429286;30705154;30728453;30765414;30975767;31409651;31844290;31848261;32119511;32157095;32179686;32329775;32387766;32488085;32494006;33141586;33214551;33243851;33298915;33446560;33465208;33852859;33968037;34019948;34211107;34301950;34509645;34725712;34822310;35051231;35385551;35561310;35580925;37217939;3757028;38665916;40596516;40914422;8566756;8608946;9016565;9242493;9512519;9524131;9539711;9671485;9701291;9731529",
        "class_list": "",
        "function": "Binds cAMP regulatory element DNA sequence. May play a role in RNA splicing., [UniProtKB, PubMed]; Binds cAMP regulatory element DNA sequence. Plays a role in RNA splicing., [UniProtKB, UniProtKB]; Functional analyses of human LUC7-like proteins involved in splicing regulation and myeloid neoplasms., [RefSeq, PubMed]; In our present RNA-Seq experiment, we demonstrated that the LUC7L3 and SFRS18 splicing factors contribute to the regulation of several well-known psoriasis-associated pathways, including the IFN signalling pathway, antiviral immunity and ubiquitination., [RefSeq, PubMed]; Results indicate that LUC7L3, PPIG, and SFRS18 are not only implicated in EDA+ fibronectin formation, but also that they could possess multiple roles in psoriasis-associated molecular abnormalities. Erratum:[Mol Cell Biochem. 2017 Dec;436(1-2):201. doi: 10.1007/s11010-017-3105-y. PMID: 28770468], [RefSeq, PubMed]; These results suggest that cisplatin affects RNA splicing by changing the subnuclear distribution of proteins including cisplatin resistance-associated overexpressed protein (CROP)., [RefSeq, PubMed]; This gene encodes a protein with an N-terminal half that contains cysteine/histidine motifs and leucine zipper-like repeats, and the C-terminal half is rich in arginine and glutamate residues (RE domain) and arginine and serine residues (RS domain). This protein localizes with a speckled pattern in the nucleus, and could be involved in the formation of splicesome via the RE and RS domains. Two alternatively spliced transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Aug 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
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        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
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        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KN54;D3DTY1;Q6PHR9;Q9NUY0;Q9P2S7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding",
        "go_cellular_component": "GO:0005685 U1 snRNP;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0071004 U2-type prespliceosome",
        "go_biological_process": "GO:0008380 RNA splicing;GO:0006376 mRNA splice site recognition",
        "synthesized_glycan_count": 0,
        "hit_score": 14.9,
        "record_id": "O95232-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P12270-1",
        "uniprot_id": [
            {
                "id": "TPR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P12270",
                "type": "external"
            }
        ],
        "mass": 267293.0,
        "length": 2363,
        "protein_name": "Nucleoprotein TPR",
        "gene_name": "TPR",
        "organism": "Human",
        "refseq_name": "nucleoprotein TPR",
        "refseq_ac": [
            {
                "id": "NP_003283",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003283",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TPR",
        "gene_names_refseq": "MRT79; TPR",
        "protein_names_uniprotkb": "Nucleoprotein TPR; Megator; NPC-associated intranuclear protein; Translocated promoter region protein",
        "protein_names_refseq": "NPC-associated intranuclear protein; megator; nuclear pore complex-associated protein TPR; nucleoprotein TPR; translocated promoter region (to activated MET oncogene); translocated promoter region protein; tumor potentiating region",
        "tax_id": 9606,
        "disease": "autosomal recessive intellectual developmental disorder (Disease Ontology:DOID:0060308); lung cancer (Disease Ontology:DOID:1324); intellectual developmental disorder, autosomal recessive 79 (MONDO:MONDO:0957288)",
        "pathway": " (hsa:7175);  (R-HSA-1169408);  (R-HSA-159227);  (R-HSA-159230);  (R-HSA-159231);  (R-HSA-159236);  (R-HSA-165054);  (R-HSA-168271);  (R-HSA-168276);  (R-HSA-168325);  (R-HSA-168333);  (R-HSA-170822);  (R-HSA-180746);  (R-HSA-180910);  (R-HSA-1855170);  (R-HSA-1855196);  (R-HSA-1855229);  (R-HSA-191859);  (R-HSA-3108214);  (R-HSA-3232142);  (R-HSA-3301854);  (R-HSA-3371453);  (R-HSA-4085377);  (R-HSA-4551638);  (R-HSA-4570464);  (R-HSA-4615885);  (R-HSA-5619107);  (R-HSA-6784531);  (R-HSA-9609690);  (R-HSA-9610379);  (R-HSA-9705671);  (R-HSA-9725370)",
        "pathway_count": 32,
        "publication_count": 661,
        "publication_id_list": 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        "class_list": "",
        "function": "Cancer-related SRCAP and TPR mutations in colon cancers., [RefSeq, PubMed]; Component of the nuclear pore complex (NPC), a complex required for the trafficking across the nuclear envelope. Functions as a scaffolding element in the nuclear phase of the NPC essential for normal nucleocytoplasmic transport of proteins and mRNAs, plays a role in the establishment of nuclear-peripheral chromatin compartmentalization in interphase, and in the mitotic spindle checkpoint signaling during mitosis. Involved in the quality control and retention of unspliced mRNAs in the nucleus; in association with NUP153, regulates the nuclear export of unspliced mRNA species bearing constitutive transport element (CTE) in a NXF1- and KHDRBS1-independent manner. Negatively regulates both the association of CTE-containing mRNA with large polyribosomes and translation initiation. Does not play any role in Rev response element (RRE)-mediated export of unspliced mRNAs. Implicated in nuclear export of mRNAs transcribed from heat shock gene promoters; associates both with chromatin in the HSP70 promoter and with mRNAs transcribed from this promoter under stress-induced conditions. Modulates the nucleocytoplasmic transport of activated MAPK1/ERK2 and huntingtin/HTT and may serve as a docking site for the XPO1/CRM1-mediated nuclear export complex. According to some authors, plays a limited role in the regulation of nuclear protein export (PubMed:11952838, PubMed:22253824). Also plays a role as a structural and functional element of the perinuclear chromatin distribution; involved in the formation and/or maintenance of NPC-associated perinuclear heterochromatin exclusion zones (HEZs). Finally, acts as a spatial regulator of the spindle-assembly checkpoint (SAC) response ensuring a timely and effective recruitment of spindle checkpoint proteins like MAD1L1 and MAD2L1 to unattached kinetochore during the metaphase-anaphase transition before chromosome congression. Its N-terminus is involved in activation of oncogenic kinases., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Identification of MKI67, TPR , and TCHH Mutations as Prognostic Biomarkers for Patients With Defective Mismatch Repair Colon Cancer Stage II/III., [RefSeq, PubMed]; Nucleoporin TPR promotes tRNA nuclear export and protein synthesis in lung cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; The human nucleoporin Tpr protects cells from RNA-mediated replication stress. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a large coiled-coil protein that forms intranuclear filaments attached to the inner surface of nuclear pore complexes (NPCs). The protein directly interacts with several components of the NPC. It is required for the nuclear export of mRNAs and some proteins. Oncogenic fusions of the 5' end of this gene with several different kinase genes occur in some neoplasias. [provided by RefSeq, Jul 2008]., [RefSeq]; ZC3HC1 Is a Novel Inherent Component of the Nuclear Basket, Resident in a State of Reciprocal Dependence with TPR. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 27,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 27,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 27,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 60,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 91,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 3,
        "glyco_site_count": 30,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15624;Q15655;Q5SWY0;Q99968",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0042803 protein homodimerization activity;GO:0031072 heat shock protein binding",
        "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0042307 positive regulation of protein import into nucleus;GO:0046832 negative regulation of RNA export from nucleus;GO:0035457 cellular response to interferon-alpha;GO:0006999 nuclear pore organization;GO:0000122 negative regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 69.3,
        "record_id": "P12270-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A2A368-1",
        "uniprot_id": [
            {
                "id": "MAGBG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A2A368",
                "type": "external"
            }
        ],
        "mass": 36178.0,
        "length": 324,
        "protein_name": "Melanoma-associated antigen B16",
        "gene_name": "MAGEB16",
        "organism": "Human",
        "refseq_name": "melanoma-associated antigen B16 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001093391",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093391",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAGEB16",
        "gene_names_refseq": "MAGEB16",
        "protein_names_uniprotkb": "Melanoma-associated antigen B16; MAGE-B16 antigen",
        "protein_names_refseq": "MAGE-B16 antigen; melanoma antigen family B, 16 (pseudogene); melanoma antigen family B16; melanoma-associated antigen B16 isoform 1; melanoma-associated antigen B16",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:139604)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;24219866;31154438",
        "class_list": "",
        "function": "The testis-specific expression of MAGEB16 and Mageb16 is regulated by the methylation status of their promoter regions., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MU30",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "A2A368-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NHJ6-1",
        "uniprot_id": [
            {
                "id": "LIRB4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NHJ6",
                "type": "external"
            }
        ],
        "mass": 49356.0,
        "length": 448,
        "protein_name": "Leukocyte immunoglobulin-like receptor subfamily B member 4",
        "gene_name": "LILRB4",
        "organism": "Human",
        "refseq_name": "leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001265356",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265356",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LILRB4; ILT3; LIR5",
        "gene_names_refseq": "B4; CD85K; ILT-3; ILT3; LILRB4; LIR-5; LIR5",
        "protein_names_uniprotkb": "Leukocyte immunoglobulin-like receptor subfamily B member 4; B4; CD85 antigen-like family member K; ILT-3; Immunoglobulin-like transcript 3; LIR-5; Leukocyte immunoglobulin-like receptor 5; Monocyte inhibitory receptor HM18",
        "protein_names_refseq": "CD85 antigen-like family member K; immunoglobulin-like transcript 3; leucocyte Ig-like receptor B4; leukocyte immunoglobulin-like receptor 5; leukocyte immunoglobulin-like receptor subfamily B member 4 isoform 2 precursor; leukocyte immunoglobulin-like receptor, subfamily B (with TM and ITIM domains), member 4; monocyte inhibitory receptor HM18",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11006);  (R-HSA-198933)",
        "pathway_count": 2,
        "publication_count": 137,
        "publication_id_list": "10499918;10746781;10941837;11237011;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11875462;11955593;11955595;11955599;12213321;12483297;12588680;14719373;14970179;15034010;15136729;15155468;15187158;15304001;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;16014749;16091383;16129954;16339513;16380601;16493035;16551255;16737824;16754721;16893496;16904340;16928187;17045824;17057721;17237375;17337780;18031695;18037897;18055229;18209062;18234675;18593354;19149696;19359216;19592130;19833736;19860908;20730098;21241660;21454581;21800138;21841309;21877119;22396535;23695528;23929856;24275569;24305946;25502872;25703557;25716998;26154972;26284469;26300885;26992070;27893789;28218747;28228285;28446606;28467828;28832583;28834231;28871256;28904123;29242379;29263213;29314611;29393594;29437277;29557506;29786170;30315122;30333625;30429286;30459171;30573663;31092671;31154438;31844290;31848261;32350084;32357974;32387766;32983136;33043033;33298915;33392160;33737684;33912179;33936100;34089617;34357683;35051231;35251023;35580925;36284347;37461040;38324114;38397424;38951916;39025844;7531291;7542404;8178173;8995416;9151699;9278324;9285412;9314561;9548455;9700512;9730896",
        "class_list": "",
        "function": "Downregulation of LILRB4 Promotes Human Aortic Smooth Muscle Cell Contractile Phenotypic Switch and Apoptosis in Aortic Dissection., [RefSeq, PubMed]; Inhibitory receptor involved in the down-regulation of the immune response and the development of immune tolerance (PubMed:11875462). Receptor for FN1 (PubMed:34089617). Receptor for apolipoprotein APOE (PubMed:30333625). Receptor for ALCAM/CD166 (PubMed:29263213). Inhibits receptor-mediated phosphorylation of cellular proteins and mobilization of intracellular calcium ions (PubMed:9151699). Inhibits FCGR1A/CD64-mediated monocyte activation by inducing phosphatase-mediated down-regulation of the phosphorylation of multiple proteins including LCK, SYK, LAT and ERK, leading to a reduction in TNF production (PubMed:19833736). This inhibition of monocyte activation occurs at least in part via binding to FN1 (PubMed:34089617). Inhibits T cell proliferation, inducing anergy, suppressing the differentiation of IFNG-producing CD8+ cytotoxic T cells and enhancing the generation of CD8+ T suppressor cells (PubMed:16493035, PubMed:19833736, PubMed:29263213). Induces up-regulation of CD86 on dendritic cells (PubMed:19860908). Interferes with TNFRSF5-signaling and NF-kappa-B up-regulation (PubMed:11875462)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; LILRB4 Checkpoint for Immunotherapy: Structure, Mechanism and Disease Targets. Review article Publication Status: Online-Only, [RefSeq, PubMed]; LILRB4 on multiple myeloma cells promotes bone lesion by p-SHP2/NF-kappaB/RELT signal pathway. Publication Status: Online-Only, [RefSeq, PubMed]; LILRB4 regulates multiple myeloma development through STAT3-PFKFB1 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; LILRB4 regulates the function of decidual MDSCs via the SHP-2/STAT6 pathway during Toxoplasma gondii infection. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the leukocyte immunoglobulin-like receptor (LIR) family, which is found in a gene cluster at chromosomal region 19q13.4. The encoded protein belongs to the subfamily B class of LIR receptors which contain two or four extracellular immunoglobulin domains, a transmembrane domain, and two to four cytoplasmic immunoreceptor tyrosine-based inhibitory motifs (ITIMs). The receptor is expressed on immune cells where it binds to MHC class I molecules on antigen-presenting cells and transduces a negative signal that inhibits stimulation of an immune response. The receptor can also function in antigen capture and presentation. It is thought to control inflammatory responses and cytotoxicity to help focus the immune response and limit autoreactivity. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 35,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 3939,
        "biomarker_type": "prognostic",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MVL8;O15468;O75021;Q6FGQ9;Q8N1C7;Q8NHL5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030547 signaling receptor inhibitor activity;GO:0034185 apolipoprotein binding;GO:0019903 protein phosphatase binding;GO:0001968 fibronectin binding;GO:0030292 protein tyrosine kinase inhibitor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0070062 extracellular exosome;GO:0009898 cytoplasmic side of plasma membrane",
        "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:1902532 negative regulation of intracellular signal transduction;GO:0032693 negative regulation of interleukin-10 production;GO:0002725 negative regulation of T cell cytokine production;GO:0032703 negative regulation of interleukin-2 production",
        "synthesized_glycan_count": 0,
        "hit_score": 14.3,
        "record_id": "Q8NHJ6-1",
        "record_type": "protein",
        "filter_code": "0001000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75391-1",
        "uniprot_id": [
            {
                "id": "SPAG7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75391",
                "type": "external"
            }
        ],
        "mass": 26034.0,
        "length": 227,
        "protein_name": "Sperm-associated antigen 7",
        "gene_name": "SPAG7",
        "organism": "Human",
        "refseq_name": "sperm-associated antigen 7",
        "refseq_ac": [
            {
                "id": "NP_004881",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004881",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SPAG7",
        "gene_names_refseq": "ACRP; FSA-1; SPAG7",
        "protein_names_uniprotkb": "Sperm-associated antigen 7",
        "protein_names_refseq": "sperm-associated antigen 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9552)",
        "pathway_count": 1,
        "publication_count": 70,
        "publication_id_list": "11237011;17693683;18669648;18767875;19413330;19651622;19664994;20068231;22223895;22424782;23186163;23301498;23783831;24452265;24715725;25576301;25645385;26154972;26992070;27600516;28228285;28832583;29242379;29393594;29493099;29557506;29786170;30410026;30524438;30620550;30833945;31154438;31222486;31373491;31530632;31844290;31848261;31937595;31998317;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33691108;33968037;33981976;34019948;34087483;34171305;34211107;34509645;34932366;35051231;35132862;35580925;35705054;36241641;36284347;38665916;40307207;40596516;7624517;9653160",
        "class_list": "",
        "function": "SPAG7 is a candidate gene for the periodic fever, aphthous stomatitis, pharyngitis and adenopathy (PFAPA) syndrome., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96EU5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005654 nucleoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "O75391-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P11150-1",
        "uniprot_id": [
            {
                "id": "LIPC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P11150",
                "type": "external"
            }
        ],
        "mass": 55914.0,
        "length": 499,
        "protein_name": "Hepatic triacylglycerol lipase",
        "gene_name": "LIPC",
        "organism": "Human",
        "refseq_name": "hepatic triacylglycerol lipase precursor",
        "refseq_ac": [
            {
                "id": "NP_000227",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000227",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LIPC; HTGL",
        "gene_names_refseq": "HDLCQ12; HL; HTGL; LIPC",
        "protein_names_uniprotkb": "Hepatic triacylglycerol lipase; 3.1.1.32; 3.1.1.3; 3.1.1.5; HL; Hepatic lipase; Lipase member C; Lysophospholipase; Phospholipase A1",
        "protein_names_refseq": "Triacylglycerol lipase; hepatic lipase; hepatic triacylglycerol lipase precursor; hepatic triacylglycerol lipase; lipase member C; lipase, hepatic; lysophospholipase; phospholipase A1",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); familial hyperlipidemia (Disease Ontology:DOID:1168); protein-energy malnutrition (Disease Ontology:DOID:11801); nephrotic syndrome (Disease Ontology:DOID:1184); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); familial combined hyperlipidemia (Disease Ontology:DOID:13809); hypothyroidism (Disease Ontology:DOID:1459); hyperinsulinism (Disease Ontology:DOID:2018); hepatitis (Disease Ontology:DOID:2237); ischemia (Disease Ontology:DOID:326); coronary artery disease (Disease Ontology:DOID:3393); peripheral vascular disease (Disease Ontology:DOID:341); kidney disease (Disease Ontology:DOID:557); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970); hyperlipidemia due to hepatic triglyceride lipase deficiency (MONDO:MONDO:0013533)",
        "pathway": " (hsa:3990);  (R-HSA-8963889);  (R-HSA-8964026)",
        "pathway_count": 3,
        "publication_count": 59,
        "publication_id_list": "10391209;10660332;10900462;11237011;12032167;12966036;1301939;15126514;15284087;15342690;15800215;16109723;17088546;17883852;17994020;17997385;18364377;19304573;19361614;20356926;20581395;21666694;21719679;21844202;22262056;22569073;22740495;23020258;23150577;2324091;24397894;2447084;24909692;24960069;25387803;2605236;26193433;26933753;26934567;26934667;2828141;2839510;32983136;33499410;33592498;33673789;35899625;36274132;37074911;37460425;7592670;7592706;8020465;8300609;8485124;8798474;8865180;9136889;9379936",
        "class_list": "",
        "function": "Association between Endothelial nitric oxide synthase and Hepatic lipase gene polymorphisms with the risk of coronary artery disease in Southern Iran population - A case control study., [RefSeq, PubMed]; Catalyzes the hydrolysis of triglycerides and phospholipids present in circulating plasma lipoproteins, including chylomicrons, intermediate density lipoproteins (IDL), low density lipoproteins (LDL) of large size and high density lipoproteins (HDL), releasing free fatty acids (FFA) and smaller lipoprotein particles. Also exhibits lysophospholipase activity. Can hydrolyze both neutral lipid and phospholipid substrates but shows a greater binding affinity for neutral lipid substrates than phospholipid substrates. In native LDL, preferentially hydrolyzes the phosphatidylcholine species containing polyunsaturated fatty acids at sn-2 position., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Downregulation of TUSC3 promotes EMT and hepatocellular carcinoma progression through LIPC/AKT axis. Publication Status: Online-Only, [RefSeq, PubMed]; Functional Haplotype of LIPC Induces Triglyceride-Mediated Suppression of HDL-C Levels According to Genome-Wide Association Studies. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of a Gain-of-Function LIPC Variant as a Novel Cause of Familial Combined Hypocholesterolemia., [RefSeq, PubMed]; [Identification and 3D architecture analysis of the LIPC gene mutation in a pedigree with familial hypercholesterolemia-like phenotype]., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 9393,
        "biomarker_type": "",
        "glycan_count": 27,
        "disease_count": 18,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RUB4;A8K9B6;O43571;P78529;Q99465",
        "ec_number_list": [
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.2.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22",
                "type": "external"
            },
            {
                "id": "3.1.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "3.1.1.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34",
                "type": "external"
            },
            {
                "id": "3.1.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23",
                "type": "external"
            },
            {
                "id": "3.1.1.79",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.79",
                "type": "external"
            },
            {
                "id": "3.1.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6",
                "type": "external"
            },
            {
                "id": "3.1.1.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.26",
                "type": "external"
            },
            {
                "id": "3.1.1.111",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.5.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1",
                "type": "external"
            },
            {
                "id": "3.1.1.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.1.1.116",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.116",
                "type": "external"
            },
            {
                "id": "3.1.1.118",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008201 heparin binding;GO:0034185 apolipoprotein binding;GO:0004620 phospholipase activity;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008970 phospholipase A1 activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0034364 high-density lipoprotein particle",
        "go_biological_process": "GO:0034638 phosphatidylcholine catabolic process;GO:0006633 fatty acid biosynthetic process;GO:0034374 low-density lipoprotein particle remodeling;GO:0034375 high-density lipoprotein particle remodeling;GO:0042632 cholesterol homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 8.9,
        "record_id": "P11150-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000100010000.111.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NA19-1",
        "uniprot_id": [
            {
                "id": "LMBL4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NA19",
                "type": "external"
            }
        ],
        "mass": 71122.0,
        "length": 623,
        "protein_name": "Lethal(3)malignant brain tumor-like protein 4",
        "gene_name": "L3MBTL4",
        "organism": "Human",
        "refseq_name": "lethal(3)malignant brain tumor-like protein 4 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_775735",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_775735",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "L3MBTL4",
        "gene_names_refseq": "HsT1031; L3MBTL4",
        "protein_names_uniprotkb": "Lethal(3)malignant brain tumor-like protein 4; H-l(3)mbt-like protein 4; L(3)mbt-like protein 4; L3mbt-like 4",
        "protein_names_refseq": "H-l(3)mbt-like protein 4; L3MBTL4, histone methyl-lysine binding protein; lethal(3)malignant brain tumor-like protein 4 isoform 1; lethal(3)malignant brain tumor-like protein 4",
        "tax_id": 9606,
        "disease": "brain cancer (Disease Ontology:DOID:1319)",
        "pathway": " (hsa:91133)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;20698951;27480026;28411811;28832583;31844290;33912179;38253038",
        "class_list": "",
        "function": "Findings pinpointed L3MBTL4 as a critical contributor to the development and progression of hypertension. Publication Status: Online-Only, [RefSeq, PubMed]; Identified L3MBTL4 as a potential tumor suppressor gene of chromosome arm 18p. The gene is targeted by deletion, breakage and mutations and its mRNA is downregulated in breast tumors Publication Status: Online-Only, [RefSeq, PubMed]; Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity)., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MTL8;Q8IXS3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0042393 histone binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q8NA19-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q12912-1",
        "uniprot_id": [
            {
                "id": "IRAG2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q12912",
                "type": "external"
            }
        ],
        "mass": 62122.0,
        "length": 555,
        "protein_name": "Inositol 1,4,5-triphosphate receptor associated 2",
        "gene_name": "IRAG2",
        "organism": "Human",
        "refseq_name": "inositol 1,4,5-triphosphate receptor associated 2 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001191055",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191055",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IRAG2; JAW1; LRMP",
        "gene_names_refseq": "IRAG2; JAW1; LRMP",
        "protein_names_uniprotkb": "Inositol 1,4,5-triphosphate receptor associated 2; Lymphoid-restricted membrane protein; Protein Jaw1",
        "protein_names_refseq": "inositol 1,4,5-triphosphate receptor associated 2 isoform a; lymphoid restricted membrane protein; protein Jaw1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4033);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 59,
        "publication_id_list": "11237011;16410263;16739114;18299280;21850230;23186163;23481700;23650620;24275569;24366607;24714562;24715725;25576301;26154972;26375851;26728094;26992070;27846572;27920218;28514659;28832583;29242379;29314611;29557506;29632046;29632711;30524438;30620550;30784271;31154438;31530632;31694064;31844290;31848261;31998317;32350084;32387766;32502341;32897882;32983136;33141586;33298915;33691108;33717175;33936100;34211107;34357683;34433824;34509645;34561969;34932366;35051231;35251023;35561310;35676525;36689741;40307207;8021504;8692836",
        "class_list": "",
        "function": "Clinical variability and probable founder effect in oculocutaneous albinism type 7., [RefSeq, PubMed]; Jaw1/LRMP increases Ca(2+) influx upon GPCR stimulation with heterogeneous effect on the activity of each ITPR subtype. Publication Status: Online-Only, [RefSeq, PubMed]; Jaw1/LRMP is associated with the maintenance of Golgi ribbon structure., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Plays a role in the delivery of peptides to major histocompatibility complex (MHC) class I molecules; this occurs in a transporter associated with antigen processing (TAP)-independent manner. May play a role in taste signal transduction via ITPR3. May play a role during fertilization in pronucleus congression and fusion. Plays a role in maintaining nuclear shape, maybe as a component of the LINC complex and through interaction with microtubules. Plays a role in the regulation of cellular excitability by regulating the hyperpolarization-activated cyclic nucleotide-gated HCN4 channel activity (By similarity)., [UniProtKB, UniProtKB]; The protein encode dby this gene is expressed in a developmentally regulated manner in lymphoid cell lines and tissues. The protein is localized to the cytoplasmic face of the endoplasmic reticulum. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 2,
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        "reported_phosphosites": 4,
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        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVM2;B4E077;Q8N301",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005635 nuclear envelope;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007338 single fertilization;GO:0006903 vesicle targeting;GO:0002376 immune system process;GO:0006997 nucleus organization;GO:0006906 vesicle fusion",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q12912-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96A59-1",
        "uniprot_id": [
            {
                "id": "MALD3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96A59",
                "type": "external"
            }
        ],
        "mass": 44911.0,
        "length": 401,
        "protein_name": "MARVEL domain-containing protein 3",
        "gene_name": "MARVELD3",
        "organism": "Human",
        "refseq_name": "MARVEL domain-containing protein 3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001017967",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017967",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MARVELD3; MRVLDC3",
        "gene_names_refseq": "MARVD3; MARVELD3; MRVLDC3",
        "protein_names_uniprotkb": "MARVEL domain-containing protein 3",
        "protein_names_refseq": "MARVEL (membrane-associating) domain containing 3; MARVEL domain-containing protein 3 isoform 1; MARVEL domain-containing protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:91862)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;20028514;20164257;21763689;24567356;33981976;34338154;36924014",
        "class_list": "",
        "function": "As a component of tight junctions, plays a role in paracellular ion conductivity., [UniProtKB, PubMed]; MARVELD3 inhibits the epithelial-mesenchymal transition and cell migration by suppressing the Wnt/beta-catenin signaling pathway in non-small cell lung cancer cells., [RefSeq, PubMed]; MarvelD3 co-localises with occludin at tight junctions in intestinal and corneal epithelial cells. Publication Status: Online-Only, [RefSeq, PubMed]; MarvelD3 couples tight junctions to the MEKK1-JNK pathway to regulate cell behavior and survival., [RefSeq, PubMed]; MarvelD3 is transcriptionally downregulated in Snail-induced epithelial-mesenchymal transition during the progression for the pancreatic cancer., [RefSeq, PubMed]; MarvelD3, occludin, and tricellulin define the tight junction-associated MARVEL protein family, [RefSeq, PubMed]; Role of tight junction-associated MARVEL protein marvelD3 in migration and epithelial-mesenchymal transition of hepatocellular carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K820;H3BQM5;Q96MJ4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0031435 mitogen-activated protein kinase kinase kinase binding",
        "go_cellular_component": "GO:0005923 bicellular tight junction;GO:0016020 membrane;GO:0031410 cytoplasmic vesicle",
        "go_biological_process": "GO:0010633 negative regulation of epithelial cell migration;GO:0006970 response to osmotic stress;GO:0050680 negative regulation of epithelial cell proliferation;GO:0070830 bicellular tight junction assembly;GO:0046329 negative regulation of JNK cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q96A59-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5JUW0-1",
        "uniprot_id": [
            {
                "id": "KRBD4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5JUW0",
                "type": "external"
            }
        ],
        "mass": 20100.0,
        "length": 171,
        "protein_name": "KRAB domain-containing protein 4",
        "gene_name": "KRABD4",
        "organism": "Human",
        "refseq_name": "KRAB domain-containing protein 4 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001123370",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123370",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KRABD4; KRBOX4; ZNF673",
        "gene_names_refseq": "KRABD4; KRBOX4; ZNF673",
        "protein_names_uniprotkb": "KRAB domain-containing protein 4; KRAB box domain-containing protein 4",
        "protein_names_refseq": "KRAB box domain containing 4; KRAB box domain-containing protein 4; KRAB domain-containing protein 4 isoform 1; KRAB domain-containing protein 4; putative zinc finger transcription factor; zinc finger family member 673; zinc finger protein 673",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55634);  (R-HSA-212436)",
        "pathway_count": 2,
        "publication_count": 52,
        "publication_id_list": "10235266;10330177;11237011;11395415;11944989;14519192;15175151;15896744;16606702;16719718;2163759;25418920;25576301;25880248;25892735;26375851;27600516;27846572;27862975;28218747;28228285;28514659;28832583;29242379;29437277;29493099;29508533;29557506;29769354;30315122;30429286;30779550;31154438;31530632;31844290;31848261;32157095;32357974;32502341;32983136;33123756;33592498;33717175;33981976;34932366;35051231;35580925;36581221;8183939;8769649;9637681;9653119",
        "class_list": "",
        "function": "This encodes a zinc finger protein with an N-terminal KRAB (Kruppel-associated) domain found in transcriptional repressors. This gene is located in a region of the X chromosome thought to be involved in nonsyndromic X-linked cognitive disability. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "A8K0Y8;B3KU22;Q96EA3;Q9NXB1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q5JUW0-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q06413-1",
        "uniprot_id": [
            {
                "id": "MEF2C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q06413",
                "type": "external"
            }
        ],
        "mass": 51221.0,
        "length": 473,
        "protein_name": "Myocyte-specific enhancer factor 2C",
        "gene_name": "MEF2C",
        "organism": "Human",
        "refseq_name": "myocyte-specific enhancer factor 2C isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001124477",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124477",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MEF2C",
        "gene_names_refseq": "C5DELq14.3; DEL5q14.3; MEF2C; NEDHSIL",
        "protein_names_uniprotkb": "Myocyte-specific enhancer factor 2C; Myocyte enhancer factor 2C",
        "protein_names_refseq": "MADS box transcription enhancer factor 2, polypeptide C; myocyte-specific enhancer factor 2C isoform 2; myocyte-specific enhancer factor 2C",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); neurodevelopmental disorder with hypotonia, stereotypic hand movements, and impaired language (Disease Ontology:DOID:0070050); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094); status epilepticus (Disease Ontology:DOID:1824); myocardial infarction (Disease Ontology:DOID:5844)",
        "pathway": " (hsa:4208);  (R-HSA-198753);  (R-HSA-2151201);  (R-HSA-525793);  (R-HSA-9022707);  (R-HSA-9707616);  (R-HSA-9733709);  (R-HSA-9931509)",
        "pathway_count": 8,
        "publication_count": 173,
        "publication_id_list": "10198158;10203015;10330143;10381560;10412986;10523670;10601328;10643692;10713165;10805738;10849446;11237011;11340167;11387216;11535832;11782431;11809803;11904443;12130498;12356737;12374852;12377782;12511571;12563009;12634428;12745923;15095414;15175654;15340086;15561718;15665827;15684387;15735306;15743823;15761026;15831463;15834131;15862299;16079181;16079853;16456541;16478538;16788062;16890199;16908542;16911507;17031457;17437997;17630987;17715127;17923681;18006707;18037887;18215119;18343819;18680753;19001277;19356719;19417006;19479054;19564926;19592390;19651622;19710360;19951946;20160094;20581824;20817722;21479263;21556048;21628546;23186163;23481700;23708187;24196956;24366607;24715725;25187301;2539258;25576301;25880248;25892735;26280087;26375851;26783251;27754849;27846572;27862975;27864847;27869121;27920218;28111073;28218747;28314751;28514659;28649982;28657654;28832583;28855257;28904123;29242379;29393594;29431698;29508533;29557506;29602958;29605689;29632046;29636455;30410026;30429286;30524438;31154438;31217245;31530632;31748741;31844290;31848261;31998317;32157095;32354867;32357974;32387766;32502341;32695117;32897882;32983136;33054971;33141586;33298915;33392160;3345742;33717175;33912179;33936100;33968037;33981976;34211107;34509645;34561969;34925382;35051231;35251023;35254053;35561310;35580925;36010968;36284347;38665916;38710877;39259737;7629110;7679508;7799916;8108407;8333869;8415693;8455629;8622974;8663403;8887638;9069290;9079689;9144434;9178750;9286700;9384584;9418854;9687510;9786951;9798649;9858528;9988769",
        "class_list": "",
        "function": "A conserved pattern of alternative splicing in vertebrate MEF2 (myocyte enhancer factor 2) genes generates an acidic activation domain in MEF2 proteins selectively in tissues where MEF2 target genes are highly expressed. (MEF2), [RefSeq, PubMed]; Aberrant ecotropic viral integration site-1 (EVI-1) and myocyte enhancer factor 2 C gene (MEF2C) in adult acute myeloid leukemia are associated with adverse t (9:22) & 11q23 rearrangements., [RefSeq, PubMed]; Direct targets of MEF2C are enriched for genes associated with schizophrenia and cognitive function and are involved in neuron development and mitochondrial function. Publication Status: Online-Only, [RefSeq, PubMed]; These results strongly suggest that haploinsufficiency of MEF2C is responsible for severe mental retardation with stereotypic movements, seizures and/or cerebral malformations., [RefSeq, PubMed]; This locus encodes a member of the MADS box transcription enhancer factor 2 (MEF2) family of proteins, which play a role in myogenesis. The encoded protein, MEF2 polypeptide C, has both trans-activating and DNA binding activities. This protein may play a role in maintaining the differentiated state of muscle cells. Mutations and deletions at this locus have been associated with severe cognitive disability, stereotypic movements, epilepsy, and cerebral malformation. Alternatively spliced transcript variants have been described. [provided by RefSeq, Jul 2010]., [RefSeq]; Transcription activator which binds specifically to the MEF2 element present in the regulatory regions of many muscle-specific genes. Controls cardiac morphogenesis and myogenesis, and is also involved in vascular development. Enhances transcriptional activation mediated by SOX18. Plays an essential role in hippocampal-dependent learning and memory by suppressing the number of excitatory synapses and thus regulating basal and evoked synaptic transmission. Crucial for normal neuronal development, distribution, and electrical activity in the neocortex. Necessary for proper development of megakaryocytes and platelets and for bone marrow B-lymphopoiesis. Required for B-cell survival and proliferation in response to BCR stimulation, efficient IgG1 antibody responses to T-cell-dependent antigens and for normal induction of germinal center B-cells. May also be involved in neurogenesis and in the development of cortical architecture (By similarity). Isoforms that lack the repressor domain are more active than isoform 1., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 26,
        "reported_mutagensis": 20,
        "reported_glycation": 0,
        "reported_snv": 24,
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        "missing_score": 0,
        "biomarker_type": "",
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        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JMZ0;D7F7N5;F8W7V7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003680 minor groove of adenine-thymine-rich DNA binding;GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0042826 histone deacetylase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0098989 NMDA selective glutamate receptor signaling pathway;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002931 response to ischemia;GO:0006351 DNA-templated transcription;GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 17.9,
        "record_id": "Q06413-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P53582-1",
        "uniprot_id": [
            {
                "id": "MAP11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P53582",
                "type": "external"
            }
        ],
        "mass": 43215.0,
        "length": 386,
        "protein_name": "Methionine aminopeptidase 1",
        "gene_name": "METAP1",
        "organism": "Human",
        "refseq_name": "methionine aminopeptidase 1",
        "refseq_ac": [
            {
                "id": "NP_055958",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055958",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METAP1; KIAA0094",
        "gene_names_refseq": "MAP1A; METAP1; MetAP1A",
        "protein_names_uniprotkb": "Methionine aminopeptidase 1; 3.4.11.18; MAP 1; MetAP 1; Peptidase M 1",
        "protein_names_refseq": "MAP 1; metAP 1; methionine aminopeptidase 1; peptidase M 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23173);  (R-HSA-2514859)",
        "pathway_count": 2,
        "publication_count": 142,
        "publication_id_list": "10037746;10051575;10564809;10676965;11237011;11292825;11601986;11687658;11713293;11754336;12036349;12119397;12144506;12499365;12825937;1356371;1379636;1387789;1436039;14702087;15592455;15946941;16274222;16724298;16823043;16895762;16908407;17114291;17636946;18803695;19818506;1999465;20068231;20430952;20975703;22645359;22658984;22706990;23767698;24714562;2540796;2550422;25505266;25576301;2558719;25645385;25880248;25892735;26154972;26375851;26728094;26824387;26992070;27542228;27846572;27862975;27920218;28218747;28228285;28510447;28832583;28834231;28904123;29242379;29314611;29331515;29393594;29437277;29493099;29508533;29557506;29632711;29786170;29789417;3006923;30315122;30410026;30429286;30779550;30833945;31154438;31530632;3164688;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32764695;32938616;32983136;33298915;33592498;33633747;33691108;33717175;33912179;33968037;33981976;34019948;34087483;34171305;34229054;34357683;34509645;34561969;34725712;34932366;35051231;35154160;35251023;35318648;35561310;35580925;36010968;36241641;36284347;36581221;38665916;4772407;6264430;7525588;7526403;7644482;7670478;7678445;7682292;7777544;7983048;8494894;8626439;8706659;8812493;9119368;9353336;9430683;9459445;9506952",
        "class_list": "",
        "function": "A comparison of the structual differences between Type I and Type II methionine aminopeptidases., [RefSeq, PubMed]; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Required for normal progression through the cell cycle., [UniProtKB, PubMed, PubMed]; Data indicate that pyridinylpyrimidine-based molecules displayed species specificity behavior against methionine aminopeptidases (MetAPs)., [RefSeq, PubMed]; Data show that human methionine aminopeptidase 1 (MetAP1) fully rescued the slow growth phenotype associated with deletion of yeast MetAP1, suggesting that the yeast and human proteins may have similar roles in vivo., [RefSeq, PubMed]; METAP1 mutation is a novel candidate for autosomal recessive intellectual disability., [RefSeq, PubMed]; MetAP1 and MetAP2 have roles in driving cell selectivity for a potent anti-cancer agent in synergy, by controlling glutathione redox state, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "biomarker_type": "",
        "glycan_count": 1,
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        "secondary_ac_list": "B4E2E6",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.4.11.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.18",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006417 regulation of translation;GO:0006508 proteolysis;GO:0070527 platelet aggregation;GO:0051604 protein maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 14.5,
        "record_id": "P53582-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "MAOM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P23368",
                "type": "external"
            }
        ],
        "mass": 65444.0,
        "length": 584,
        "protein_name": "NAD-dependent malic enzyme, mitochondrial",
        "gene_name": "ME2",
        "organism": "Human",
        "refseq_name": "NAD-dependent malic enzyme, mitochondrial isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001161807",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161807",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ME2",
        "gene_names_refseq": "ME2; ODS1",
        "protein_names_uniprotkb": "NAD-dependent malic enzyme, mitochondrial; 1.1.1.38; Malic enzyme 2; NAD-ME",
        "protein_names_refseq": "NAD-ME; NAD-dependent malic enzyme, mitochondrial isoform 2 precursor; malate dehydrogenase (oxaloacetate-decarboxylating); malic enzyme 2, NAD(+)-dependent, mitochondrial; pyruvic-malic carboxylase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4200);  (R-HSA-70268);  (R-HSA-9837999)",
        "pathway_count": 3,
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        "class_list": "",
        "function": "Expression levels of SIX1, ME2, and AP2M1 in adenoid cystic carcinoma and mucoepidermoid carcinoma., [RefSeq, PubMed]; Influences susceptibility to adolescent-onset genetic generalized epilepsy, [RefSeq, PubMed]; Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate., [RefSeq, PubMed]; NAD-dependent mitochondrial malic enzyme that catalyzes the oxidative decarboxylation of malate to pyruvate., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; SIRT5-mediated ME2 desuccinylation promotes cancer growth by enhancing mitochondrial respiration., [RefSeq, PubMed]; This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. [provided by RefSeq, Dec 2009]., [RefSeq]",
        "predicted_glycosites": 0,
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        "reported_mutagensis": 2,
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        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8J2;Q9BWL6;Q9BYG1;Q9H4B2",
        "ec_number_list": [
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                "id": "2.3.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.3.1",
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            {
                "id": "7.1.1.2",
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                "id": "2.3.1.168",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168",
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            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
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                "id": "2.3.1.37",
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            {
                "id": "1.1.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38",
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            {
                "id": "2.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9",
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                "id": "1.2.1.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.36",
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            {
                "id": "1.7.1.-",
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                "id": "3.4.21.53",
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                "id": "1.1.1.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.37",
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            {
                "id": "1.3.8.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.1",
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            {
                "id": "1.3.8.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.8.5",
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                "id": "1.1.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.40",
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                "id": "1.1.1.41",
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                "id": "1.2.4.2",
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                "id": "1.1.1.30",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30",
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            {
                "id": "5.3.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.3.21",
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                "id": "2.7.11.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.2",
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            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
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                "id": "3.4.21.92",
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                "id": "4.1.1.112",
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                "id": "6.2.1.-",
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                "id": "6.2.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.4",
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            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
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                "id": "1.1.1.62",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.62",
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            {
                "id": "1.1.1.239",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.239",
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            {
                "id": "1.1.1.178",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.178",
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            {
                "id": "1.1.1.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.53",
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            },
            {
                "id": "1.1.1.159",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.159",
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            },
            {
                "id": "4.2.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.3",
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            {
                "id": "6.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.1.1.5",
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            },
            {
                "id": "2.3.1.41",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41",
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            }
        ],
        "go_molecular_function": "GO:0008948 oxaloacetate decarboxylase activity;GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051287 NAD binding;GO:0004471 malate dehydrogenase (decarboxylating) (NAD+) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006108 malate metabolic process;GO:1902031 regulation of NADP metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.4,
        "record_id": "P23368-1",
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    },
    {
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            {
                "id": "LRC23_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q53EV4",
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            }
        ],
        "mass": 39761.0,
        "length": 343,
        "protein_name": "Leucine-rich repeat-containing protein 23",
        "gene_name": "LRRC23",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 23 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001128689",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128689",
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            }
        ],
        "gene_names_uniprotkb": "LRRC23; LRPB7",
        "gene_names_refseq": "LRPB7; LRRC23; SPGF92",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 23; Leucine-rich protein B7",
        "protein_names_refseq": "leucine-rich protein B7; leucine-rich repeat-containing protein 23 isoform a; leucine-rich repeat-containing protein 23",
        "tax_id": 9606,
        "disease": "spermatogenic failure 92 (Disease Ontology:DOID:0070591)",
        "pathway": " (hsa:10233)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;28649982;28904123;29557506;31429579;31844290;32157095;32357974;32938616;37804054;38091523;39054792;39894887;9074930",
        "class_list": "",
        "function": "Essential for sperm motility and male fertility. Plays an important role in the proper assembly of the third radial spoke (RS3) head and the bridge structure between RS2 and RS3 in the sperm flagella., [UniProtKB, PubMed, PubMed]; LRRC23 deficiency causes male infertility with idiopathic asthenozoospermia by disrupting the assembly of radial spokes., [RefSeq, PubMed]; LRRC23 truncation impairs radial spoke 3 head assembly and sperm motility underlying male infertility. Publication Status: Online-Only, [RefSeq, PubMed]; Novel mutations in LRRC23 cause asthenozoospermia in a nonconsanguineous family., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8C6;D3DUT1;Q8N6K6;Q92977;Q99620",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0036126 sperm flagellum",
        "go_biological_process": "GO:0030317 flagellated sperm motility;GO:0062177 radial spoke assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q53EV4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96KN8-1",
        "uniprot_id": [
            {
                "id": "PLAT5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96KN8",
                "type": "external"
            }
        ],
        "mass": 30312.0,
        "length": 279,
        "protein_name": "Phospholipase A and acyltransferase 5",
        "gene_name": "PLAAT5",
        "organism": "Human",
        "refseq_name": "phospholipase A and acyltransferase 5 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001140200",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001140200",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLAAT5; HRASLS5; HRLP5",
        "gene_names_refseq": "HRASLS5; HRLP5; HRSL5; PLAAT-5; PLAAT5; RLP1; iNAT",
        "protein_names_uniprotkb": "Phospholipase A and acyltransferase 5; 2.3.1.-; 3.1.1.32; 3.1.1.4; Ca(2+)-independent N-acyltransferase; H-rev107-like protein 5; HRAS-like suppressor 5; HRSL5; iNAT",
        "protein_names_refseq": "Ca(2+)-independent N-acyltransferase; H-rev107-like protein 5; HRAS like suppressor family member 5; HRAS-like suppressor 5; calcium-independent phosphatidylethanolamine N-acyltransferase; lecithin-retinol acyltransferase (LRAT)-like protein-1; phospholipase A and acyltransferase 5 isoform 3; phospholipase A/acyltransferase-5; testicular tissue protein Li 90",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:117245);  (R-HSA-1482839)",
        "pathway_count": 2,
        "publication_count": 36,
        "publication_id_list": "10092647;10336645;10455175;10681567;11031251;11112443;11237011;11830583;12161451;12359733;12522102;15695510;15863501;15944408;16617059;16818490;18195019;18287005;18458083;18614531;18772128;18781350;19000777;19019078;19351971;19501189;20705608;22605381;22825852;26503625;2925608;2925633;7060561;8300559;9188469;9417066",
        "class_list": "",
        "function": "Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:22825852). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19000777, PubMed:22825852)., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
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        "reported_o_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 0,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7X6T1;F5GZ87;F5H4Y9",
        "ec_number_list": [
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "3.1.1.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.111",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111",
                "type": "external"
            },
            {
                "id": "3.1.1.118",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0016410 N-acyltransferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0070292 N-acylphosphatidylethanolamine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q96KN8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UHV8-1",
        "uniprot_id": [
            {
                "id": "PP13_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UHV8",
                "type": "external"
            }
        ],
        "mass": 16119.0,
        "length": 139,
        "protein_name": "Galactoside-binding soluble lectin 13",
        "gene_name": "LGALS13",
        "organism": "Human",
        "refseq_name": "galactoside-binding soluble lectin 13",
        "refseq_ac": [
            {
                "id": "NP_037400",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037400",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LGALS13; PLAC8",
        "gene_names_refseq": "GAL13; LGALS13; PLAC8; PP13",
        "protein_names_uniprotkb": "Galactoside-binding soluble lectin 13; Gal-13; Galectin-13; PP13; Placental protein 13; Placental tissue protein 13",
        "protein_names_refseq": "beta-galactoside-binding lectin; gal-13; galactoside-binding soluble lectin 13; lectin, galactoside-binding, soluble, 13; placental protein 13; placental tissue protein 13",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29124)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "10527825;11237011;11742106;19497882;29343868;30413611;31584064;37569423;37641375;38186168;39064506;40246981;6856484",
        "class_list": "glycogene",
        "function": "Augmented Placental Protein 13 in Placental-Associated Extracellular Vesicles in Term and Preterm Preeclampsia Is Further Elevated by Corticosteroids. Publication Status: Online-Only, [RefSeq, PubMed]; Binds beta-galactoside and lactose. Strong inducer of T-cell apoptosis (PubMed:10527825, PubMed:19497882). Has hemagglutinating activity towards chicken erythrocytes (PubMed:29343868). Acts as an activator of ferroptosis: secreted by ferroptotic cells and acts by reducing localization of SLC7A11 at the plasma membrane (PubMed:40246981)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Intronic variants of LGALS13 gene encoding placental protein (PP13) are linked with increased risk of infection-associated spontaneous preterm birth., [RefSeq, PubMed]; Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. The protein encoded by this gene has lysophospholipase activity. It is composed of two identical subunits which are held together by disulfide bonds. This protein has structural similarity to several members of the beta-galactoside-binding S-type lectin family. [provided by RefSeq, Jul 2008]., [RefSeq]; Placental Protein 13 and Syncytiotrophoblast Basement Membrane Ultrastructures in Preeclampsia. Publication Status: Online-Only, [RefSeq, PubMed]; The primary structure of the newly sequence analysed placental tissue protein 13 (PP13) was highly homologous to several members of the beta-galactoside-binding S-type lectin (galectin) family, [RefSeq, PubMed]; [Predictive value of serum Gal-13, GLP-1 and VEGF levels in adverse pregnancy outcomes of gestational diabetes mellitus]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 214,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C5HZ15",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0030246 carbohydrate binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016363 nuclear matrix",
        "go_biological_process": "GO:0006915 apoptotic process;GO:1903077 negative regulation of protein localization to plasma membrane;GO:0006644 phospholipid metabolic process;GO:0160020 positive regulation of ferroptosis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q9UHV8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43934-1",
        "uniprot_id": [
            {
                "id": "MFS11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43934",
                "type": "external"
            }
        ],
        "mass": 49202.0,
        "length": 449,
        "protein_name": "UNC93-like protein MFSD11",
        "gene_name": "MFSD11",
        "organism": "Human",
        "refseq_name": "UNC93-like protein MFSD11 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001229461",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229461",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MFSD11; ET",
        "gene_names_refseq": "ET; MFSD11",
        "protein_names_uniprotkb": "UNC93-like protein MFSD11; Major facilitator superfamily domain-containing protein 11; Protein ET",
        "protein_names_refseq": "UNC93-like protein MFSD11 isoform 1; UNC93-like protein MFSD11; major facilitator superfamily domain-containing protein 11; protein ET",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79157)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "11237011;18691976;26288249;27846572;28218747;28904123;28940097;29242379;29288388;29314611;29437277;29769354;29786170;30192525;30410026;31844290;32157095;32161166;32350084;32357974;32938616;32983136;33968037;33981976;34357683;35051231;35580925;36010968;9358160",
        "class_list": "",
        "function": "Results from a study on gene expression variability markers in early-stage human embryos shows that MFSD11 is a putative marker for the 3-day, 8-cell embryo stage. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O43442;Q9NXI5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "O43934-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IZK6-1",
        "uniprot_id": [
            {
                "id": "MCLN2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IZK6",
                "type": "external"
            }
        ],
        "mass": 65942.0,
        "length": 566,
        "protein_name": "Mucolipin-2",
        "gene_name": "MCOLN2",
        "organism": "Human",
        "refseq_name": "mucolipin-2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001317576",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317576",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MCOLN2",
        "gene_names_refseq": "MCOLN2; TRP-ML2; TRPML2",
        "protein_names_uniprotkb": "Mucolipin-2; TRPML2; Transient receptor potential channel mucolipin 2",
        "protein_names_refseq": "mucolipin-2 isoform 2; transient receptor potential channel mucolipin 2",
        "tax_id": 9606,
        "disease": "mucolipidosis type IV (Disease Ontology:DOID:0080490); glycoproteinosis (Disease Ontology:DOID:3343)",
        "pathway": " (hsa:255231);  (R-HSA-3295583)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "11050376;11226139;11237011;11243859;11301059;12015988;12403827;1422598;14634208;16606612;17662026;19763610;19885840;19940139;20025796;20716668;22299025;25130899;25389312;25418920;25502872;25765567;25855297;26811146;27248469;27846572;27920218;28063628;28218747;28228285;28467828;28514659;28649982;28904123;29242379;29314611;29382735;29393594;29437277;29493099;29557506;29632046;29632711;29769354;29774024;31178222;31844290;32265295;32350084;32357974;32387766;32983136;33392160;33717175;33936100;34078123;34357683;34433824;34548638;34932366;35054871;35154160;35580925",
        "class_list": "",
        "function": "Endolysosomal ion channel MCOLN2 (Mucolipin-2) promotes prostate cancer progression via IL-1beta/NF-kappaB pathway., [RefSeq, PubMed]; Functional In Vitro Assessment of VEGFA/NOTCH2 Signaling Pathway and pRB Proteasomal Degradation and the Clinical Relevance of Mucolipin TRPML2 Overexpression in Glioblastoma Patients. Publication Status: Online-Only, [RefSeq, PubMed]; High TRPML-2 expression in glioma cells resulted in increased survival and proliferation signaling, suggesting a pro-tumorigenic role played by TRPML-2 in glioma progression., [RefSeq, PubMed]; MCOLN2 traffics through the ADP-ribosylation factor 6 (Arf6)-associated pathway, colocalizing with major histocompatibility protein class I and CD59 in long recycling endosomes., [RefSeq, PubMed]; Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]).[supplied by OMIM, Sep 2009]., [RefSeq]; Nonselective cation channel probably playing a role in the regulation of membrane trafficking events. Acts as a Ca(2+)-permeable cation channel with inwardly rectifying activity (PubMed:19885840, PubMed:19940139). May activate ARF6 and be involved in the trafficking of GPI-anchored cargo proteins to the cell surface via the ARF6-regulated recycling pathway (PubMed:17662026). May play a role in immune processes. In adaptive immunity, TRPML2 and TRPML1 may play redundant roles in the function of the specialized lysosomes of B cells (By similarity). In the innate immune response, may play a role in the regulation of chemokine secretion and macrophage migration (By similarity). Through a possible and probably tissue-specific heteromerization with MCOLN1 may be at least in part involved in many lysosome-dependent cellular events (PubMed:19885840). Also functions as a Fe(2+) permeable channel (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; TRPML1 appears to play a novel role in the tissue-specific transcriptional regulation of TRPML2., [RefSeq, PubMed]; The acidic TRPML2 extracytosolic/lumenal domain (ELD) pre-pore loop exhibits a pH-dependent Ca2+ interaction, suggesting a mechanism for channel activity regulation in the endolysosomal system., [RefSeq, PubMed]; The authors show that MCOLN2 specifically promotes viral vesicular trafficking and subsequent escape from endosomal compartments. This mechanism requires channel activity, occurs independently of antiviral signaling, and broadly applies to enveloped RNA viruses that require transport to late endosomes for infection, including influenza A virus, yellow fever virus, and Zika virus. Publication Status: Online-Only, [RefSeq, PubMed]; There is a hierarchy controlling the subcellular distributions of the TRPMLs such that TRPML1 and TRPML2 dictate the localization of TRPML3 and not vice versa, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0072345 NAADP-sensitive calcium-release channel activity;GO:0005262 calcium channel activity;GO:0042802 identical protein binding;GO:0005381 iron ion transmembrane transporter activity;GO:0005261 monoatomic cation channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031902 late endosome membrane;GO:0055038 recycling endosome membrane",
        "go_biological_process": "GO:0015031 protein transport;GO:0045087 innate immune response;GO:0002250 adaptive immune response;GO:0070588 calcium ion transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 6.4,
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    },
    {
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            {
                "id": "KT222_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N1A0",
                "type": "external"
            }
        ],
        "mass": 34158.0,
        "length": 295,
        "protein_name": "Keratin-like protein KRT222",
        "gene_name": "KRT222",
        "organism": "Human",
        "refseq_name": "keratin-like protein KRT222",
        "refseq_ac": [
            {
                "id": "NP_689562",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689562",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KRT222; KA21; KRT222P",
        "gene_names_refseq": "KA21; KRT222P; KRT222",
        "protein_names_uniprotkb": "Keratin-like protein KRT222; Keratin-222 pseudogene; Keratin-222",
        "protein_names_refseq": "keratin 222, type II; keratin-222 pseudogene; keratin-like protein KRT222",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:125113)",
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        "publication_count": 6,
        "publication_id_list": "11237011;16831889;28657654;29393594;31844290;37376412",
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        "go_molecular_function": "GO:0005198 structural molecule activity",
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    },
    {
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            {
                "id": "RL15_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P61313",
                "type": "external"
            }
        ],
        "mass": 24146.0,
        "length": 204,
        "protein_name": "Large ribosomal subunit protein eL15",
        "gene_name": "RPL15",
        "organism": "Human",
        "refseq_name": "large ribosomal subunit protein eL15 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001240308",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240308",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RPL15; EC45; TCBAP0781",
        "gene_names_refseq": "DBA12; EC45; L15; RPL10; RPL15; RPLY10; RPYL10; eL15",
        "protein_names_uniprotkb": "Large ribosomal subunit protein eL15; 60S ribosomal protein L15",
        "protein_names_refseq": "60S ribosomal protein L15; large ribosomal subunit protein eL15 isoform 1; large ribosomal subunit protein eL15",
        "tax_id": 9606,
        "disease": "Diamond-Blackfan anemia 12 (Disease Ontology:DOID:0111882)",
        "pathway": " (hsa:6138);  (R-HSA-156827);  (R-HSA-156902);  (R-HSA-1799339);  (R-HSA-192823);  (R-HSA-2408557);  (R-HSA-6791226);  (R-HSA-72689);  (R-HSA-72706);  (R-HSA-72764);  (R-HSA-9010553);  (R-HSA-9633012);  (R-HSA-975956);  (R-HSA-975957);  (R-HSA-9954709);  (R-HSA-9954714);  (R-HSA-9954716)",
        "pathway_count": 17,
        "publication_count": 299,
        "publication_id_list": "10358005;10659855;1095581;10970870;10982836;11018020;11018027;11237011;11265756;11331269;11532962;11544179;11546874;11551508;11677247;11691921;11726970;11922599;11964406;12068309;12150911;12417715;12493757;12554878;12588972;12718880;12832468;12853463;1400365;1448153;14527413;14567916;14630918;14636577;14654843;14742663;14973490;15034551;15317934;15385533;15534230;15546618;15721257;15775988;15781252;15821744;16026328;16037817;16043514;16186820;16209946;16284618;16408927;16452507;16469117;16601204;16622410;16630668;16738141;16989641;17053788;17074750;17142313;17145369;17189298;17267404;17352659;17353269;17363904;17412707;17726049;17803942;17893241;18065403;18066079;18166647;18230761;18256688;18285520;18423202;18438418;18447580;18447585;18455985;18524595;18539146;1856230;1861871;18657639;18669648;18691976;18974281;19007248;19060897;19106111;19150429;19332556;19359157;19369195;19417104;19478851;19503078;19556969;19564402;19608919;19706539;19801658;19859661;19909264;20023408;20038530;20056613;2006156;20068231;20112406;20361218;20444697;20479275;20531386;20691628;20798176;20805244;20817927;20819938;20930030;21029861;21036871;21063389;21097556;21145460;21406692;21419344;21612406;22072790;22190735;22195017;22645359;22916032;23085078;23186163;23217742;23234702;23269699;23439679;23481700;23482395;23636399;23685075;23746841;23812780;2388630;24424021;24524803;24550520;24714562;24715725;25132172;25242263;25255805;25418920;25469497;25525153;25576301;25578875;25645385;25802875;25880248;25892735;25969445;26024233;26154972;26237581;26375851;26728094;26768311;26811146;26992070;27397612;27452731;27526673;27846572;27920218;28063628;28065601;28132843;28218747;28228285;28685749;28832583;28834231;28904123;29242379;29314611;29331515;29393594;29413899;29437277;29493099;29508533;29557506;29632046;29632312;29632711;29786170;29789417;30244831;30293783;30315122;30410026;30429286;30484775;30524438;30779550;30804176;30833945;31011209;31020640;31154438;31217245;31530632;31611695;31844290;31848261;31998317;32099016;32119511;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32579943;32669547;32897882;32938616;32983136;33043033;33091337;33141586;33214551;33298915;33392160;33406423;33537174;33592498;33633747;33691108;33717175;33909987;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34357683;34509645;34561969;34725712;35051231;35083852;35138101;35251023;35318648;35561310;35580925;35856393;36010968;36215666;36241641;36284347;36302773;36581221;37217939;37431269;37676773;37938771;38665916;39395807;429297;592398;592399;641056;6568109;6901506;7990965;8336711;8407925;8890909;9211906;9431993;9482744;9631292;9637248;9712840",
        "class_list": "",
        "function": "Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Decreased expression of RPL15 and RPL18 exacerbated the calcification of valve interstitial cells during aortic valve calcification., [RefSeq, PubMed]; Detection of mRNAs of Ribosomal Protein L15 and E-Cadherin in Living Circulating Tumor Cells at Single Cell Resolution To Study Tumor Heterogeneity., [RefSeq, PubMed]; Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of four RNA species and approximately 80 structurally distinct proteins. This gene encodes a member of the L15E family of ribosomal proteins and a component of the 60S subunit. This gene shares sequence similarity with the yeast ribosomal protein YL10 gene. Elevated expression of this gene has been observed in esophageal tumors and gastric cancer tissues, and deletion of this gene has been observed in a Diamond-Blackfan anemia (DBA) patient. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Mar 2017]., [RefSeq]",
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        "secondary_ac_list": "P39030;P41051;Q5U0C0;Q642I1;Q6IPX6;Q8WYP2;Q96C44;Q9H2E5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0045296 cadherin binding;GO:0003735 structural constituent of ribosome",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0045202 synapse;GO:0005840 ribosome",
        "go_biological_process": "GO:1901740 negative regulation of myoblast fusion;GO:0007283 spermatogenesis;GO:0006412 translation;GO:0006941 striated muscle contraction;GO:0002181 cytoplasmic translation",
        "synthesized_glycan_count": 0,
        "hit_score": 30.3,
        "record_id": "P61313-1",
        "record_type": "protein",
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    },
    {
        "uniprot_canonical_ac": "Q15048-1",
        "uniprot_id": [
            {
                "id": "LRC14_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15048",
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            }
        ],
        "mass": 54513.0,
        "length": 493,
        "protein_name": "Leucine-rich repeat-containing protein 14",
        "gene_name": "LRRC14",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 14",
        "refseq_ac": [
            {
                "id": "NP_001258965",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258965",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC14; KIAA0014",
        "gene_names_refseq": "LRRC14A; LRRC14",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 14",
        "protein_names_refseq": "leucine-rich repeat-containing protein 14",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9684);  (R-HSA-9758274)",
        "pathway_count": 2,
        "publication_count": 50,
        "publication_id_list": "11237011;15389287;20112406;20434986;21703539;22424782;23481700;24366607;24715725;25576301;25892735;26154972;26240016;26620909;26992070;27426725;27862975;27920218;28228285;28904123;29393594;29508533;29632046;29769354;29786170;30315122;30379171;30484775;30524438;31154438;31217245;31530632;31826938;31844290;31998317;32265295;32357974;32387766;32897882;32938616;33298915;33654074;33717175;33968037;33981976;34171305;34509645;35051231;36010968;36284347",
        "class_list": "",
        "function": "Negatively regulates Toll-like receptor-mediated NF-kappa-B signaling by disrupting IKK core complex formation through interaction with IKBKB., [UniProtKB, PubMed]; TLR signaling led to lower expression of LRRC14., [RefSeq, PubMed]; This gene encodes a leucine-rich repeat-containing protein. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Dec 2012]., [RefSeq]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "A8K0A8;D3DWM8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019900 kinase binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0034122 negative regulation of toll-like receptor signaling pathway",
        "synthesized_glycan_count": 0,
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TCA0-1",
        "uniprot_id": [
            {
                "id": "LRC20_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TCA0",
                "type": "external"
            }
        ],
        "mass": 20509.0,
        "length": 184,
        "protein_name": "Leucine-rich repeat-containing protein 20",
        "gene_name": "LRRC20",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 20 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001265140",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265140",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC20; PRO4989",
        "gene_names_refseq": "LRRC20",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 20",
        "protein_names_refseq": "leucine-rich repeat-containing protein 20 isoform 1; leucine-rich repeat-containing protein 20",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55222)",
        "pathway_count": 1,
        "publication_count": 55,
        "publication_id_list": "11237011;12975309;16385451;20659327;23186163;23481700;24366607;24714562;24715725;25418920;25576301;25810538;26154972;26375851;26728094;26992070;27397612;27600516;27846572;27862975;28218747;28228285;28832583;28834231;28904123;29242379;29437277;29557506;29789417;30315122;30410026;30429286;30779550;31092671;31217245;31844290;31998317;32157095;32161166;32357974;32502341;32983136;33141586;33298915;33392160;33717175;33936100;33968037;33981976;34211107;34357683;34932366;35051231;35580925;36241641",
        "class_list": "",
        "function": "Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q5T6D4;Q5T6D6;Q9NVA6;Q9NVG3",
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            {
                "id": "MAGIX_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H6Y5",
                "type": "external"
            }
        ],
        "mass": 35273.0,
        "length": 334,
        "protein_name": "PDZ domain-containing protein MAGIX",
        "gene_name": "MAGIX",
        "organism": "Human",
        "refseq_name": "PDZ domain-containing protein MAGIX isoform c",
        "refseq_ac": [
            {
                "id": "NP_001093151",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093151",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAGIX",
        "gene_names_refseq": "JM10; MAGIX; PDZX",
        "protein_names_uniprotkb": "PDZ domain-containing protein MAGIX",
        "protein_names_refseq": "PDZ domain containing, X chromosome; PDZ domain-containing protein MAGIX isoform c; PDZ domain-containing protein MAGIX",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79917)",
        "pathway_count": 1,
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        "publication_id_list": "11237011;32938616",
        "class_list": "",
        "function": "",
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        "secondary_ac_list": "A0A075B7A2;A6XND4;A8MSX9;B7WP26;Q14C81",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
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        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A8MSI8-1",
        "uniprot_id": [
            {
                "id": "LYRM9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A8MSI8",
                "type": "external"
            }
        ],
        "mass": 9374.0,
        "length": 78,
        "protein_name": "LYR motif-containing protein 9",
        "gene_name": "LYRM9",
        "organism": "Human",
        "refseq_name": "LYR motif-containing protein 9",
        "refseq_ac": [
            {
                "id": "NP_001070148",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070148",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LYRM9; C17orf108; HSD24",
        "gene_names_refseq": "C17orf108; HSD24; LYRM9",
        "protein_names_uniprotkb": "LYR motif-containing protein 9",
        "protein_names_refseq": "LYR motif-containing protein 9; UPF0631 protein C17orf108",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:201229)",
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        "publication_id_list": "11237011;24315451;39894887",
        "class_list": "",
        "function": "3 SNPs associated with the fraction of exhaled nitric oxide in childhood asthma are rs3751972 in LYRM9; rs944722 in NOS2; and rs8069176 near GSDMB; all at 17q12-q21., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "A6NJT7;Q6X7B8",
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion",
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        "record_id": "A8MSI8-1",
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    },
    {
        "uniprot_canonical_ac": "Q8NG27-1",
        "uniprot_id": [
            {
                "id": "PJA1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NG27",
                "type": "external"
            }
        ],
        "mass": 71002.0,
        "length": 643,
        "protein_name": "E3 ubiquitin-protein ligase Praja-1",
        "gene_name": "PJA1",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase Praja-1 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001027568",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027568",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PJA1; RNF70",
        "gene_names_refseq": "PJA1; PRAJA1; RNF70",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase Praja-1; 2.3.2.27; Praja1; RING finger protein 70; RING-type E3 ubiquitin transferase Praja-1",
        "protein_names_refseq": "E3 ubiquitin-protein ligase Praja-1 isoform b; E3 ubiquitin-protein ligase Praja-1; RING finger protein 70; RING-type E3 ubiquitin transferase Praja-1; praja 1; praja ring finger 1, E3 ubiquitin protein ligase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64219);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 87,
        "publication_id_list": "11062501;11237011;11350924;11959851;12036302;12646216;14734113;15224091;15224092;15571818;16595681;16849449;16954532;18662542;19028597;19352404;19452197;19489725;19664995;19690332;19851334;19874575;19940261;21406692;2261476;22898188;23186163;23481700;23783831;25505266;25576301;25892735;26758079;26992070;27920218;28218747;28228285;28514659;28832583;28904123;29242379;29331515;29508533;29632711;29769354;30192525;30315122;30379171;30429286;30524438;30620550;30779550;30833945;31154438;31217245;31222486;31530632;31844290;32157095;32161166;32488085;32686212;32897882;32938616;32983136;33091337;33298915;33592498;33691108;33717175;33839405;33912179;33968037;34087483;34161122;34405274;34509645;34932366;35051231;35318648;35580925;36010968;36241641;37938771;38906860;9380723;9668046",
        "class_list": "",
        "function": "A RING finger protein Praja1 regulates Dlx5-dependent transcription through its ubiquitin ligase activity for the Dlx/Msx-interacting MAGE/Necdin family protein, Dlxin-1., [RefSeq, PubMed]; E3 ubiquitin ligase PJA1 regulates lung adenocarcinoma apoptosis and invasion through promoting FOXR2 degradation., [RefSeq, PubMed]; Has E2-dependent E3 ubiquitin-protein ligase activity. Ubiquitinates MAGED1 antigen leading to its subsequent degradation by proteasome (By similarity). May be involved in protein sorting., [UniProtKB, PubMed]; Involved in protein ubiquitination in the brain. Candidate gene for X-linked mental retardation., [RefSeq, PubMed]; PJA1-mediated suppression of pyroptosis as a driver of docetaxel resistance in nasopharyngeal carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Praja1 RING-finger E3 ubiquitin ligase suppresses neuronal cytoplasmic TDP-43 aggregate formation., [RefSeq, PubMed]; Praja1 ubiquitin ligase facilitates degradation of polyglutamine proteins and suppresses polyglutamine-mediated toxicity., [RefSeq, PubMed]; This gene encodes an enzyme that has E2-dependent E3 ubiquitin-protein ligase activity. This enzyme belongs to a class of ubiquitin ligases that include a RING finger motif, and it can interact with the E2 ubiquitin-conjugating enzyme UbcH5B. This gene is located in an area of chromosome X where several X-linked cognitive disability disorders have been associated, and it has also been found as part of a contiguous gene deletion associated with craniofrontonasal syndrome, though a direct link to any disorder has yet to be demonstrated. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]., [RefSeq]",
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        "secondary_ac_list": "A2A322;Q5JUT8;Q5JUT9;Q8NG28;Q9HAC1",
        "ec_number_list": [
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
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            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
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            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
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        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0016567 protein ubiquitination",
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    },
    {
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            {
                "id": "SPDE2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q495Y8",
                "type": "external"
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        ],
        "mass": 48300.0,
        "length": 402,
        "protein_name": "Speedy protein E2",
        "gene_name": "SPDYE2",
        "organism": "Human",
        "refseq_name": "speedy protein E2",
        "refseq_ac": [
            {
                "id": "NP_001026789",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026789",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SPDYE2",
        "gene_names_refseq": "SPDYB2-L1; SPDYB2L1; SPDYE2",
        "protein_names_uniprotkb": "Speedy protein E2",
        "protein_names_refseq": "Speedy B2-like 1; putative Speedy protein E2; speedy homolog E2; speedy protein E2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:441273)",
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        "publication_count": 2,
        "publication_id_list": "25418920;34509645",
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        "secondary_ac_list": "B4DY11",
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        "go_molecular_function": "GO:0019901 protein kinase binding",
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        "record_id": "Q495Y8-1",
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    },
    {
        "uniprot_canonical_ac": "Q9H171-1",
        "uniprot_id": [
            {
                "id": "ZBP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H171",
                "type": "external"
            }
        ],
        "mass": 46343.0,
        "length": 429,
        "protein_name": "Z-DNA-binding protein 1",
        "gene_name": "ZBP1",
        "organism": "Human",
        "refseq_name": "Z-DNA-binding protein 1 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001153889",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153889",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZBP1; C20orf183; DLM1",
        "gene_names_refseq": "C20orf183; DAI; DLM-1; DLM1; ZBP1",
        "protein_names_uniprotkb": "Z-DNA-binding protein 1; DAI; DNA-dependent activator of IFN-regulatory factors; Tumor stroma and activated macrophage protein DLM-1",
        "protein_names_refseq": "DNA-dependent activator of IRFs; Z-DNA-binding protein 1 isoform b; tumor stroma and activated macrophage protein DLM-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81030);  (R-HSA-1606322);  (R-HSA-1606341);  (R-HSA-1810476);  (R-HSA-3134975);  (R-HSA-9679191)",
        "pathway_count": 6,
        "publication_count": 61,
        "publication_id_list": "10087012;10723127;11237011;11842111;12221085;12692549;15145317;16056267;16115318;16115877;16448869;16522641;16876127;16990255;17047224;17526488;17618271;17662961;18375758;18941233;19095800;19590578;19666475;20223979;20696886;21074459;21471454;21862588;22388039;22401777;22552008;22745133;22814904;23222971;23283962;23396211;23641311;24272870;24584101;25173411;25801024;26002965;26992070;27701768;28425720;28832583;29236673;29242379;29945920;30201761;31048504;32200799;32350084;33348174;33981976;34087483;38507125;38748877;38982083;39215796;9463386",
        "class_list": "",
        "function": "(Microbial infection) In case of herpes simplex virus 1/HHV-1 infection, forms hetero-amyloid structures with HHV-1 protein RIR1/ICP6 which may inhibit ZBP1-mediated necroptosis, thereby preventing host cell death pathway and allowing viral evasion., [UniProtKB, PubMed]; A ZBP1 isoform blocks ZBP1-mediated cell death., [RefSeq, PubMed]; Binding 2 DAIs to 1 dsDNA brings about dimerization of DAI that might facilitate DNA-mediated innate immune activation., [RefSeq, PubMed]; Highly Expressed Z-DNA Binding Protein 1 in Esophageal Cancer Promotes Tumor Growth., [RefSeq, PubMed]; Key innate sensor that recognizes and binds Z-RNA structures, which are produced by a number of viruses, such as herpesvirus, orthomyxovirus or flavivirus, and triggers different forms of cell death (PubMed:32200799). ZBP1 acts as an essential mediator of pyroptosis, necroptosis and apoptosis (PANoptosis), an integral part of host defense against pathogens, by activating RIPK3, caspase-8 (CASP8), and the NLRP3 inflammasome (By similarity). Key activator of necroptosis, a programmed cell death process in response to death-inducing TNF family members, via its ability to bind Z-RNA: once activated upon Z-RNA-binding, ZBP1 interacts and stimulates RIPK3 kinase, which phosphorylates and activates MLKL, triggering execution of programmed necrosis (By similarity). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: ZBP1 recognizes and binds Z-RNA structures that are produced in infected nuclei by orthomyxoviruses, such as the influenza A virus (IAV), leading to ZBP1 activation, RIPK3 stimulation and subsequent MLKL phosphorylation, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (PubMed:32200799). ZBP1-dependent cell death in response to IAV infection promotes interleukin-1 alpha (IL1A) induction in an NLRP3-inflammasome-independent manner: IL1A expression is required for the optimal interleukin-1 beta (IL1B) production, and together, these cytokines promote infiltration of inflammatory neutrophils to the lung, leading to the formation of neutrophil extracellular traps (By similarity). In addition to its direct role in driving necroptosis via its ability to sense Z-RNAs, also involved in PANoptosis triggered in response to bacterial infection: component of the AIM2 PANoptosome complex, a multiprotein complex that triggers PANoptosis (By similarity). Also acts as the apical sensor of fungal infection responsible for activating PANoptosis (By similarity). Involved in CASP8-mediated cell death via its interaction with RIPK1 but independently of its ability to sense Z-RNAs (By similarity). In some cell types, also able to restrict viral replication by promoting cell death-independent responses (By similarity). In response to Zika virus infection in neurons, promotes a cell death-independent pathway that restricts viral replication: together with RIPK3, promotes a death-independent transcriptional program that modifies the cellular metabolism via up-regulation expression of the enzyme ACOD1/IRG1 and production of the metabolite itaconate (By similarity). Itaconate inhibits the activity of succinate dehydrogenase, generating a metabolic state in neurons that suppresses replication of viral genomes (By similarity)., [UniProtKB, PubMed, UniProtKB]; Molecular cloning and structure analysis, [RefSeq, PubMed]; Solution NMR backbone assignment of the N-terminal tandem Zalpha1-Zalpha2 domains of Z-DNA binding protein 1., [RefSeq, PubMed]; This gene encodes a Z-DNA binding protein. The encoded protein plays a role in the innate immune response by binding to foreign DNA and inducing type-I interferon production. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Dec 2011]., [RefSeq]; Z-DNA binding activities of two Zalpha domains in the human ZBP1, hZalpha(ZBP1) and hZbeta(ZBP1)were characterized., [RefSeq, PubMed]; ZBP1 condensate formation synergizes Z-NAs recognition and signal transduction. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A2F7;B3KVA1;F5GYT1;Q5JY39;Q9BYW4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003692 left-handed Z-DNA binding;GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042802 identical protein binding;GO:0003725 double-stranded RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:2000659 regulation of interleukin-1-mediated signaling pathway;GO:0043065 positive regulation of apoptotic process;GO:0051607 defense response to virus;GO:0006915 apoptotic process;GO:0050727 regulation of inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q9H171-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BUT9-1",
        "uniprot_id": [
            {
                "id": "MCRI2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BUT9",
                "type": "external"
            }
        ],
        "mass": 17828.0,
        "length": 160,
        "protein_name": "MAPK regulated corepressor interacting protein 2",
        "gene_name": "MCRIP2",
        "organism": "Human",
        "refseq_name": "MAPK regulated corepressor interacting protein 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001318158",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001318158",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MCRIP2; C16orf14; FAM195A",
        "gene_names_refseq": "C16orf14; FAM195A; MCRIP2; c349E10.1",
        "protein_names_uniprotkb": "MAPK regulated corepressor interacting protein 2; Protein FAM195A",
        "protein_names_refseq": "MAPK regulated co-repressor interacting protein 2; MAPK regulated corepressor interacting protein 2 isoform 2; family with sequence similarity 195, member A; protein FAM195A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84331)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;18669648;19651622;20068231;23186163;24129315;24275569;24715725;26184334;26811146;26992070;27920218;28832583;28904123;29242379;29453251;29485866;29557506;30524438;31844290;32157095;32350084;32897882;34019948;35251023;35318648",
        "class_list": "",
        "function": "Novel adipokine, FAM19A5, was capable of inhibiting postinjury neointima formation via sphingosine-1-phosphate receptor 2-G12/13-RhoA signaling., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
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        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
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        "reported_snv": 0,
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        "missing_score": 0,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q969E9;Q96KV8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0010494 cytoplasmic stress granule",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q9BUT9-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P16109-1",
        "uniprot_id": [
            {
                "id": "LYAM3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P16109",
                "type": "external"
            }
        ],
        "mass": 90820.0,
        "length": 830,
        "protein_name": "P-selectin",
        "gene_name": "SELP",
        "organism": "Human",
        "refseq_name": "P-selectin precursor",
        "refseq_ac": [
            {
                "id": "NP_002996",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002996",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SELP; GMRP; GRMP",
        "gene_names_refseq": "CD62P; CD62; GMP140; GRMP; LECAM3; PADGEM; PSEL; SELP",
        "protein_names_uniprotkb": "P-selectin; CD62 antigen-like family member P; GMP-140; Granule membrane protein 140; LECAM3; Leukocyte-endothelial cell adhesion molecule 3; PADGEM; Platelet activation dependent granule-external membrane protein",
        "protein_names_refseq": "CD62 antigen-like family member P; GMP-140; P-selectin precursor; P-selectin; granule membrane protein 140; granulocyte membrane protein; leukocyte-endothelial cell adhesion molecule 3; platelet activation dependent granule-external membrane protein; platelet activation-dependent granule to external membrane protein; platelet alpha-granule membrane protein; selectin P (granule membrane protein 140kDa, antigen CD62)",
        "tax_id": 9606,
        "disease": "colitis (Disease Ontology:DOID:0060180); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); brain small vessel disease (Disease Ontology:DOID:0112313); Alzheimer's disease (Disease Ontology:DOID:10652); Sjogren's syndrome (Disease Ontology:DOID:12894); Kawasaki disease (Disease Ontology:DOID:13378); atherosclerosis (Disease Ontology:DOID:1936); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); ulcerative colitis (Disease Ontology:DOID:8577); intermediate coronary syndrome (Disease Ontology:DOID:8805); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:6403);  (R-HSA-114608);  (R-HSA-202733)",
        "pathway_count": 3,
        "publication_count": 113,
        "publication_id_list": "10391209;10606205;10764623;11081633;11207550;11237011;11237770;11256994;11564780;11779189;11812992;12070135;12208882;12469115;12782713;12929084;1375831;1377048;1435334;14529530;14615387;14630798;14681304;15000751;15297306;15528364;15681301;15721307;15769472;1591491;16258728;16263699;16297198;16585556;16691243;16710414;16737840;16783819;1694218;1701178;17064312;17099249;17116209;17167768;17172599;17322099;17379836;17442946;17452516;17505016;17525755;17563375;17580308;17600130;17615384;17625065;18606703;19279206;21193412;21659548;23090970;23640497;23945545;24043627;2466574;24764293;2538457;27726376;27893789;28011641;28832583;29314611;29391424;29632711;31848261;32619411;32757722;33232787;33259230;33805059;34015287;34399825;37074911;37184585;37759488;37926453;37938771;37978991;38243063;38497867;468991;6457647;7505680;7509040;7521878;7559387;7585949;7585950;7684381;8163559;8166770;8314844;8467233;8901515;9052782;9169774;9242610;9295288;9382878;9466983;9668170;9693095;9763524",
        "class_list": "glycogene",
        "function": "Association of the rs3917647 polymorphism of the SELP gene with malnutrition in gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Ca(2+)-dependent receptor for myeloid cells that binds to carbohydrates on neutrophils and monocytes. Mediates the interaction of activated endothelial cells or platelets with leukocytes. The ligand recognized is sialyl-Lewis X. Mediates rapid rolling of leukocyte rolling over vascular surfaces during the initial steps in inflammation through interaction with SELPLG. Mediates cell-cell interactions and cell adhesion via the interaction with integrin alpha-IIb/beta3 (ITGA2B:ITGB3) and integrin alpha-V/beta-3 (ITGAV:ITGB3) (PubMed:37184585)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Clinical significance of elevated soluble T-cell immunoglobulin and mucin domain 1 and soluble P-selectin in individuals with obstructive sleep apnea-hypopnea syndrome., [RefSeq, PubMed]; High expression of angiotensin-converting enzyme 2 receptor (ACE-2), transmembrane protease serine (TMPRSS), and P-selectin in platelets lead to thrombosis formation in COVID-19 patients., [RefSeq, PubMed]; PSGL-1 decorated with sialyl Lewis[a/x] promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a 140 kDa protein that is stored in the alpha-granules of platelets and Weibel-Palade bodies of endothelial cells. This protein redistributes to the plasma membrane during platelet activation and degranulation and mediates the interaction of activated endothelial cells or platelets with leukocytes. The membrane protein is a calcium-dependent receptor that binds to sialylated forms of Lewis blood group carbohydrate antigens on neutrophils and monocytes. Alternative splice variants may occur but are not well documented. [provided by RefSeq, Jul 2008]., [RefSeq]; Virtual Screening of Protein Data Bank via Docking Simulation Identified the Role of Integrins in Growth Factor Signaling, the Allosteric Activation of Integrins, and P-Selectin as a New Integrin Ligand. Review article Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 11,
        "predicted_n_glycosites": 9,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
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        "total_n_glycosites": 4,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 1351,
        "reported_interactions": 0,
        "missing_score": 8657,
        "biomarker_type": "prognostic",
        "glycan_count": 8,
        "disease_count": 18,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5R344;Q8IVD1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0070492 oligosaccharide binding;GO:0005178 integrin binding;GO:0008201 heparin binding;GO:0048306 calcium-dependent protein binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0031092 platelet alpha granule membrane;GO:0031088 platelet dense granule membrane",
        "go_biological_process": "GO:0033623 regulation of integrin activation;GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0007155 cell adhesion;GO:0032496 response to lipopolysaccharide;GO:0050829 defense response to Gram-negative bacterium",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "P16109-1",
        "record_type": "protein",
        "filter_code": "0001000.1100111.100000.000000000001000000.1000000011000.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UX40-1",
        "uniprot_id": [
            {
                "id": "TM107_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UX40",
                "type": "external"
            }
        ],
        "mass": 15503.0,
        "length": 140,
        "protein_name": "Transmembrane protein 107",
        "gene_name": "TMEM107",
        "organism": "Human",
        "refseq_name": "transmembrane protein 107 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_115730",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115730",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TMEM107; DC20; PRO1268",
        "gene_names_refseq": "GRVS638; JBTS29; MKS13; PRO1268; TMEM107",
        "protein_names_uniprotkb": "Transmembrane protein 107",
        "protein_names_refseq": "transmembrane protein 107 isoform 1",
        "tax_id": 9606,
        "disease": "Meckel syndrome 13 (Disease Ontology:DOID:0080253); orofaciodigital syndrome XVI (Disease Ontology:DOID:0080254)",
        "pathway": " (hsa:84314)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "11237011;12975309;19727342;20112406;24714562;25418920;25645385;26123494;26154972;26518474;26595381;26811146;26992070;27920218;28063628;28228285;28832583;28834231;29242379;29393594;29493099;29557506;29632046;31844290;32387766;33717175;35318648;35580925;37863656",
        "class_list": "",
        "function": "Plays a role in cilia formation and embryonic patterning. Requires for normal Sonic hedgehog (Shh) signaling in the neural tube and acts in combination with GLI2 and GLI3 to pattern ventral and intermediate neuronal cell types (By similarity). During ciliogenesis regulates the ciliary transition zone localization of some MKS complex proteins (PubMed:26518474)., [UniProtKB, UniProtKB, PubMed]; Role of ciliopathy protein TMEM107 in eye development: insights from a mouse model and retinal organoid. Publication Status: Online-Only, [RefSeq, PubMed]; TMEM107 (2810049P21Rik) is a strong candidate gene for central areolar choroidal dystrophy, CACD (human 17p13). Conclusion is based on a massive expression data set for mouse (103 strains in GeneNetwork.org) and joint analysis of RetNet database. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a transmembrane protein and component of the primary cilia transition zone. The encoded protein regulates ciliogenesis and ciliary protein composition. Human fibroblasts expressing a mutant allele of this gene exhibit reduced numbers of cilia, altered cilia length, and impaired sonic hedgehog signaling. In human patients, different mutations in this gene cause different ciliopathies, including Meckel-Gruber syndrome and orofaciodigital syndrome. [provided by RefSeq, May 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "reported_mutagensis": 0,
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        "reported_snv": 3,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0PJV7;Q6NSE3;Q6ZRX9;Q96T82",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane;GO:0036038 MKS complex;GO:0035869 ciliary transition zone",
        "go_biological_process": "GO:0060271 cilium assembly;GO:0042733 embryonic digit morphogenesis;GO:0021532 neural tube patterning;GO:1905515 non-motile cilium assembly;GO:1904491 protein localization to ciliary transition zone",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q6UX40-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H8J5-1",
        "uniprot_id": [
            {
                "id": "MANS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H8J5",
                "type": "external"
            }
        ],
        "mass": 46810.0,
        "length": 431,
        "protein_name": "MANSC domain-containing protein 1",
        "gene_name": "MANSC1",
        "organism": "Human",
        "refseq_name": "MANSC domain-containing protein 1 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_060520",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060520",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MANSC1; LOH12CR3; PRO361",
        "gene_names_refseq": "9130403P13Rik; LOH12CR3; MANSC1",
        "protein_names_uniprotkb": "MANSC domain-containing protein 1; Loss of heterozygosity 12 chromosomal region 3 protein",
        "protein_names_refseq": "MANSC domain-containing protein 1 isoform 1 precursor; MANSC domain-containing protein 1; loss of heterozygosity 12 chromosomal region 3 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54682)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;11237011;11896457;12975309;23584533;25813380;30459171;31611695;31844290;32157095;32350084;33392160;33592498;33968037;34087483;35051231;35251023;35705054",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 5,
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        "reported_o_glycosites_with_glycan": 17,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 24,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NEC1;Q9NW60",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q9H8J5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75112-1",
        "uniprot_id": [
            {
                "id": "LDB3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75112",
                "type": "external"
            }
        ],
        "mass": 77135.0,
        "length": 727,
        "protein_name": "LIM domain-binding protein 3",
        "gene_name": "LDB3",
        "organism": "Human",
        "refseq_name": "LIM domain-binding protein 3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001073583",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073583",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LDB3; KIAA0613; ZASP",
        "gene_names_refseq": "CMD1C; CMD2L; CMH24; CMPD3; CYPHER; LDB3Z1; LDB3Z4; LDB3; LVNC3; MFM4; ORACLE; PDLIM6; ZASP",
        "protein_names_uniprotkb": "LIM domain-binding protein 3; Protein cypher; Z-band alternatively spliced PDZ-motif protein",
        "protein_names_refseq": "LIM domain-binding protein 3 isoform 2; LIM domain-binding protein 3; PDZ and LIM domain 6; Z-band alternatively spliced PDZ-motif protein; cardiomyopathy, dilated 1C (autosomal dominant); protein cypher",
        "tax_id": 9606,
        "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myofibrillar myopathy 1 (Disease Ontology:DOID:0080092); myofibrillar myopathy 4 (Disease Ontology:DOID:0080095); congenital myopathy (Disease Ontology:DOID:0081337); dilated cardiomyopathy 1C (Disease Ontology:DOID:0110423); distal myopathy (Disease Ontology:DOID:11720); myotonic dystrophy type 1 (Disease Ontology:DOID:11722); dilated cardiomyopathy (Disease Ontology:DOID:12930); myopathy (Disease Ontology:DOID:423); cardiomyopathy, dilated, 2l (MONDO:MONDO:0979236)",
        "pathway": " (hsa:11155)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "10427098;11237011;11842093;14660611;14662268;15062084;15668942;16427346;17097056;23271734;25208129;25616123;26154972;27600516;28832583;28834231;29242379;29557506;31092671;32157095;32938616;33592498;33968037;34185709;34932366;35051231;35580925;36253531;38928252",
        "class_list": "",
        "function": "Association between ZASP/LDB3 Pro26Ser and Inclusion Body Myopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Biallelic loss of LDB3 leads to a lethal pediatric dilated cardiomyopathy., [RefSeq, PubMed]; May function as an adapter in striated muscle to couple protein kinase C-mediated signaling via its LIM domains to the cytoskeleton., [UniProtKB]; This gene encodes a PDZ domain-containing protein. PDZ motifs are modular protein-protein interaction domains consisting of 80-120 amino acid residues. PDZ domain-containing proteins interact with each other in cytoskeletal assembly or with other proteins involved in targeting and clustering of membrane proteins. The protein encoded by this gene interacts with alpha-actinin-2 through its N-terminal PDZ domain and with protein kinase C via its C-terminal LIM domains. The LIM domain is a cysteine-rich motif defined by 50-60 amino acids containing two zinc-binding modules. This protein also interacts with all three members of the myozenin family. Mutations in this gene have been associated with myofibrillar myopathy and dilated cardiomyopathy. Alternatively spliced transcript variants encoding different isoforms have been identified; all isoforms have N-terminal PDZ domains while only longer isoforms (1, 2 and 5) have C-terminal LIM domains. [provided by RefSeq, Jan 2010]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 10,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2TDB7;A6NIV4;B4E3K3;Q5K6N9;Q5K6P0;Q5K6P1;Q96FH2;Q9Y4Z3;Q9Y4Z4;Q9Y4Z5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding;GO:0005080 protein kinase C binding;GO:0008092 cytoskeletal protein binding",
        "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005912 adherens junction;GO:0048471 perinuclear region of cytoplasm;GO:0001725 stress fiber;GO:0030018 Z disc",
        "go_biological_process": "GO:0007507 heart development;GO:0030036 actin cytoskeleton organization;GO:0061061 muscle structure development",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "O75112-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q3ZCW2-1",
        "uniprot_id": [
            {
                "id": "LEGL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q3ZCW2",
                "type": "external"
            }
        ],
        "mass": 18986.0,
        "length": 172,
        "protein_name": "Galectin-related protein",
        "gene_name": "LGALSL",
        "organism": "Human",
        "refseq_name": "galectin-related protein",
        "refseq_ac": [
            {
                "id": "NP_054900",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054900",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LGALSL; GRP; HSPC159",
        "gene_names_refseq": "GRP; HSPC159; LGALSL",
        "protein_names_uniprotkb": "Galectin-related protein; Galectin-like protein; Lectin galactoside-binding-like protein",
        "protein_names_refseq": "galectin-like protein; galectin-related protein; lectin galactoside-binding-like protein; lectin, galactoside binding like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29094)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;16682780;18219197;18320588;18433051;18669648;20068231;24715725;26375851;28228285;28411811;29737572;30833945;31154438;31530632;31844290;32157095;33968037;36580660",
        "class_list": "glycogene",
        "function": "CCL13 and HSPC159 mRNA expressions in PBMC are up-regulated specifically in MCNS patients during the nephrosis phase., [RefSeq, PubMed]; Does not bind lactose, and may not bind carbohydrates., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Galectin-related protein is a novel protein that has a close similarity to galectin sequences but is not a member of the galectin family because of its lack of lactose-binding activity. The crystal structure has been solved., [RefSeq, PubMed]; Galectin-related protein named GRP comprises only one conserved carbohydrate-recognition domain with 38 additional N-terminal residues.  The crystals belong to the monoclinic space group C2., [RefSeq, PubMed]; Our findings showed that HSPC159 contributed to breast cancer progression through the PI3K/Akt pathway, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 185,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBG8;D6W5E8;Q6P5T6;Q9P005",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030246 carbohydrate binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q3ZCW2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000001.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y234-1",
        "uniprot_id": [
            {
                "id": "LIPT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y234",
                "type": "external"
            }
        ],
        "mass": 42479.0,
        "length": 373,
        "protein_name": "Lipoyl amidotransferase LIPT1, mitochondrial",
        "gene_name": "LIPT1",
        "organism": "Human",
        "refseq_name": "lipoyl amidotransferase LIPT1, mitochondrial precursor",
        "refseq_ac": [
            {
                "id": "NP_001191759",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191759",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LIPT1",
        "gene_names_refseq": "LIPT1D; LIPT1",
        "protein_names_uniprotkb": "Lipoyl amidotransferase LIPT1, mitochondrial; 2.3.1.-; 2.3.1.200; Lipoate biosynthesis protein; Lipoate-protein ligase; Lipoyl ligase; Lipoyltransferase 1",
        "protein_names_refseq": "lipoate biosynthesis protein; lipoyl amidotransferase LIPT1, mitochondrial precursor; lipoyl amidotransferase LIPT1, mitochondrial; lipoyl ligase; lipoyltransferase 1, mitochondrial",
        "tax_id": 9606,
        "disease": "Leigh disease (Disease Ontology:DOID:3652); lipoyl transferase 1 deficiency (MONDO:MONDO:0014576)",
        "pathway": " (hsa:51601);  (R-HSA-9857492)",
        "pathway_count": 2,
        "publication_count": 29,
        "publication_id_list": "10103005;11237011;11389890;19570983;20877624;21846720;22152680;24256811;24341803;26154972;28757203;28832583;28904123;29242379;29681092;29987032;30429286;31042466;31844290;31848261;32357974;32387766;32938616;34357683;36195876;37453661;37481209;37668796;38041690",
        "class_list": "",
        "function": "Aberrant expression of cuproptosis-related gene LIPT1 is associated with metabolic dysregulation of fatty acid and prognosis in hepatocellular carcinoma., [RefSeq, PubMed]; Cuproptosis-related gene LIPT1 as a prognostic indicator in non-small cell lung cancer: Functional involvement and regulation of ATOX1 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Lipoyl amidotransferase that catalyzes the transfer of lipoyl moieties from lipoyl-protein H of the glycine cleavage system (lipoyl-GCSH) to E2 subunits of the pyruvate dehydrogenase complex (PDCE2) (PubMed:29987032). Unable to catalyze the transfer of octanoyl from octanoyl-GCSH to PDCE2 (PubMed:29987032). In vitro, it is also able to catalyze the transfer of the lipoyl group from lipoyl-AMP to the specific lysine residue of lipoyl domains of lipoate-dependent enzymes but this reaction may not be physiologically relevant (Probable)., [UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; System analysis based on the cuproptosis-related genes identifies LIPT1 as a novel therapy target for liver hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The process of transferring lipoic acid to proteins is a two-step process. The first step is the activation of lipoic acid by lipoate-activating enzyme to form lipoyl-AMP. For the second step, the protein encoded by this gene transfers the lipoyl moiety to apoproteins. Alternative splicing results in multiple transcript variants. A related pseudogene has been identified on chromosome 13. Read-through transcription also exists between this gene and the neighboring downstream mitochondrial ribosomal protein L30 (MRPL30) gene. [provided by RefSeq, Mar 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4ZFZ1",
        "ec_number_list": [
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.12",
                "type": "external"
            },
            {
                "id": "2.3.1.168",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.168",
                "type": "external"
            },
            {
                "id": "2.3.1.61",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.61",
                "type": "external"
            },
            {
                "id": "2.3.1.200",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.200",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016410 N-acyltransferase activity;GO:0017118 lipoyltransferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0036211 protein modification process;GO:0006629 lipid metabolic process;GO:0009249 protein lipoylation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q9Y234-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NG13-1",
        "uniprot_id": [
            {
                "id": "MGT4D_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NG13",
                "type": "external"
            }
        ],
        "mass": 43743.0,
        "length": 374,
        "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D",
        "gene_name": "MGAT4D",
        "organism": "Human",
        "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D precursor",
        "refseq_ac": [
            {
                "id": "NP_001264282",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264282",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MGAT4D",
        "gene_names_refseq": "GnT1IP; MGAT4D",
        "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D; GlcNAcT-I inhibitory protein; GnT1IP; N-acetylglucosaminyltransferase MGAT1 inhibitory protein",
        "protein_names_refseq": "GlcNAcT-I Inhibitory Protein; N-acetylglucosaminyltransferase MGAT1 inhibitory protein; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D precursor; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase-like protein MGAT4D; glycosyltransferase 54 domain containing 1; glycosyltransferase 54 domain-containing protein; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase family, member D",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:152586)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;16773575;26371870;32763972;37217939;39302247",
        "class_list": "glycogene;glycosyltransferase",
        "function": "May play a role in male spermatogenesis. In vitro acts as inhibitor of MGAT1 activity causing cell surface proteins to carry mainly high mannose N-glycans. The function is mediated by its lumenal domain and occurs specifically in the Golgi. A catalytic glucosyltransferase activity is not detected. May be involved in regulation of Sertoli-germ cell interactions during specific stages of spermatogenesis., [UniProtKB, UniProtKB]; Point mutations that inactivate MGAT4D-L, an inhibitor of MGAT1 and complex N-glycan synthesis., [RefSeq, PubMed]; The authors show here that the luminal domain of GnT1IP-L contains its MGAT1 inhibitory activity. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 347,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008375 acetylglucosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0005795 Golgi stack;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0006487 protein N-linked glycosylation;GO:0010561 negative regulation of glycoprotein biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "A6NG13-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P06858-1",
        "uniprot_id": [
            {
                "id": "LIPL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P06858",
                "type": "external"
            }
        ],
        "mass": 53162.0,
        "length": 475,
        "protein_name": "Lipoprotein lipase",
        "gene_name": "LPL",
        "organism": "Human",
        "refseq_name": "lipoprotein lipase precursor",
        "refseq_ac": [
            {
                "id": "NP_000228",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000228",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LPL; LIPD",
        "gene_names_refseq": "HDLCQ11; LIPD; LPL",
        "protein_names_uniprotkb": "Lipoprotein lipase; 3.1.1.32; 3.1.1.34; LPL; Phospholipase A1",
        "protein_names_refseq": "lipoprotein lipase precursor; phospholipase A1",
        "tax_id": 9606,
        "disease": "alcohol-associated liver disease (Disease Ontology:DOID:0070658); muscular disease (Disease Ontology:DOID:0080000); metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); familial combined hyperlipidemia (Disease Ontology:DOID:13809); familial lipoprotein lipase deficiency (Disease Ontology:DOID:14118); abdominal obesity-metabolic syndrome 1 (Disease Ontology:DOID:14221); coronary artery disease (Disease Ontology:DOID:3393); myocardial infarction (Disease Ontology:DOID:5844); end stage renal disease (Disease Ontology:DOID:783); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:4023);  (R-HSA-381340);  (R-HSA-8963889);  (R-HSA-8963901);  (R-HSA-975634);  (R-HSA-9841922)",
        "pathway_count": 6,
        "publication_count": 221,
        "publication_id_list": "10.1101/2023.09.13.557529;10052934;10075656;10391209;10425206;10558993;10660334;10769148;10787434;10835357;10882139;10900462;11027271;11060341;11068186;11095972;11099402;11134145;11181758;11237011;11274389;11342582;11441134;11872672;11893776;12032167;12204001;12213831;12641539;1279089;12829629;12966036;1301939;1310260;1371284;1400331;1406652;1479292;14984478;15185149;1521525;15256764;15273253;15284087;15358783;1537564;1542003;15583000;15800215;15850785;15877202;15919796;1598907;16109723;16179346;1619366;16200213;16380219;1639392;1674945;16939223;17011499;1702428;17088546;1730727;17525477;1752947;17644776;17761950;17883852;17980149;17994020;17997385;18087047;18295589;18460466;18507396;1856611;18780401;18931025;19014918;19043829;1907278;19115207;19139408;19172745;19304573;19361614;1969408;1975597;20068231;20101261;2010533;20356926;2038366;20581395;21081667;2110364;21106934;2121025;21385844;21666694;21719679;21844202;21851338;22262056;2243796;22569073;22740495;23020258;23150577;23239344;2340307;24106281;24291057;24397894;24726386;24909692;24960069;25066055;25387803;26725083;26933753;26934567;26934667;26992070;2701938;27452731;27578112;27811232;27862975;2793848;28327359;29557506;29899144;30559189;31844290;32125861;32157095;32350084;32897882;32938616;32983136;33043033;33091337;33329381;33592498;33968037;34019948;35051231;35251023;35580925;36241641;3714052;37901192;37938771;38114521;3823907;38342095;38429792;38530959;3942763;4345202;5057882;5675424;6420172;6961410;7592670;7592706;7647785;7683668;7806969;7906986;7912254;7999071;8017323;8020465;8077845;8096693;8135797;8288243;8300609;8301230;8308035;8325954;8325986;8384721;8485124;8486765;8521497;8521498;8643605;8675619;8706692;8728311;8728326;8770873;8778602;8858123;8872057;8956048;8956052;8970730;8973094;9065481;9136889;9171241;9279761;9298816;9379936;9401010;9454824;9498099;9662394;9714430;9719626;9744270;9836620;9888420;9920938;9925661",
        "class_list": "",
        "function": "Association of lipoprotein lipase (LPL) gene variants with hyperlipidemic acute pancreatitis in southeastern Chinese population., [RefSeq, PubMed]; Developing a model to predict the early risk of hypertriglyceridemia based on inhibiting lipoprotein lipase (LPL): a translational study. Publication Status: Online-Only, [RefSeq, PubMed]; Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage (PubMed:11342582, PubMed:27578112, PubMed:8675619). Although it has both phospholipase and triglyceride lipase activities it is primarily a triglyceride lipase with low but detectable phospholipase activity (PubMed:12032167, PubMed:7592706). Mediates margination of triglyceride-rich lipoprotein particles in capillaries (PubMed:24726386). Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans (PubMed:11342582, PubMed:27811232)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; LPL encodes lipoprotein lipase, which is expressed in heart, muscle, and adipose tissue. LPL functions as a homodimer, and has the dual functions of triglyceride hydrolase and ligand/bridging factor for receptor-mediated lipoprotein uptake. Severe mutations that cause LPL deficiency result in type I hyperlipoproteinemia, while less extreme mutations in LPL are linked to many disorders of lipoprotein metabolism. [provided by RefSeq, Jul 2008]., [RefSeq]; Metabolic syndrome risk in adult coffee drinkers with the rs301 variant of the LPL gene. Publication Status: Online-Only, [RefSeq, PubMed]; Relationship between Lipoprotein Lipase Derived from Subcutaneous Adipose Tissue and Cardio-Ankle Vascular Index in Japanese Patients with Severe Obesity., [RefSeq, PubMed]; The Association of Adipokines and Myokines in the Blood of Obese Children and Adolescents with Lipoprotein Lipase rs328 Gene Variants. Publication Status: Online-Only, [RefSeq, PubMed]",
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        "reported_mutagensis": 18,
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        "biomarker_type": "",
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        "ec_number_list": [
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                "id": "2.1.1.364",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364",
                "type": "external"
            },
            {
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                "type": "external"
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
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                "id": "5.6.2.6",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
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        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008201 heparin binding;GO:0034185 apolipoprotein binding;GO:0042803 protein homodimerization activity;GO:0043395 heparan sulfate proteoglycan binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0034361 very-low-density lipoprotein particle",
        "go_biological_process": "GO:0031670 cellular response to nutrient;GO:1904179 positive regulation of adipose tissue development;GO:0001523 retinoid metabolic process;GO:0006631 fatty acid metabolic process;GO:0006641 triglyceride metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 25.1,
        "record_id": "P06858-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H063-1",
        "uniprot_id": [
            {
                "id": "MAF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H063",
                "type": "external"
            }
        ],
        "mass": 28771.0,
        "length": 256,
        "protein_name": "Repressor of RNA polymerase III transcription MAF1 homolog",
        "gene_name": "MAF1",
        "organism": "Human",
        "refseq_name": "repressor of RNA polymerase III transcription MAF1 homolog",
        "refseq_ac": [
            {
                "id": "NP_115648",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115648",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAF1",
        "gene_names_refseq": "MAF1",
        "protein_names_uniprotkb": "Repressor of RNA polymerase III transcription MAF1 homolog",
        "protein_names_refseq": "MAF1 homolog, negative regulator of RNA polymerase III; homolog of yeast MAF1; repressor of RNA polymerase III transcription MAF1 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84232);  (R-HSA-8943724)",
        "pathway_count": 2,
        "publication_count": 87,
        "publication_id_list": "11230166;11237011;11378386;11438659;11545734;11781575;11959846;12504022;16418168;16676006;16702404;17081983;17205138;17499043;17505538;17873065;17974977;18077418;18172008;18377933;18391013;18487508;18669648;19440552;19651622;19690332;19884659;20068231;20233713;20516213;20543138;20887893;21289308;21406692;22128185;23186163;23287862;23673667;24718924;25576301;25728608;26375851;26910647;26941251;26992070;27600516;27862975;27920218;28832583;28904123;29242379;29393594;29557506;29632711;29786170;30315122;30524438;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;32066962;32157095;32387766;32938616;32983136;33298915;33592498;33640883;33717175;33912179;33968037;34087483;34171305;34509645;34932366;35051231;35561310;35580925;36010968;36215666;36284347;37938771",
        "class_list": "",
        "function": "Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA., [UniProtKB, UniProtKB]; Functional studies of the yeast counterpart., [RefSeq, PubMed, PubMed]; Maf1 can be co-immunoprecipitated with pol III and associates in vitro with two pol III subunits, the largest subunit RPC1 and the alpha-like subunit RPAC2. Maf1 represses pol III transcription in vitro and in vivo. Publication Status: Online-Only, [RefSeq, PubMed]; Maf1 suppression of ATF5-dependent mitochondrial unfolded protein response contributes to rapamycin-induced radio-sensitivity in lung cancer cell line A549., [RefSeq, PubMed]; Plays a role in the repression of RNA polymerase III-mediated transcription in response to changing nutritional, environmental and cellular stress conditions to balance the production of highly abundant tRNAs, 5S rRNA, and other small non-coding RNAs with cell growth and maintenance (PubMed:18377933, PubMed:20233713, PubMed:20516213, PubMed:20543138). Also plays a key role in cell fate determination by promoting mesorderm induction and adipocyte differentiation (By similarity). Mechanistically, associates with the RNA polymerase III clamp and thereby impairs its recruitment to the complex made of the promoter DNA, TBP and the initiation factor TFIIIB (PubMed:17505538, PubMed:20887893). When nutrients are available and mTOR kinase is active, MAF1 is hyperphosphorylated and RNA polymerase III is engaged in transcription. Stress-induced MAF1 dephosphorylation results in nuclear localization, increased targeting of gene-bound RNA polymerase III and a decrease in the transcriptional readout (PubMed:26941251). Additionally, may also regulate RNA polymerase I and RNA polymerase II-dependent transcription through its ability to regulate expression of the central initiation factor TBP (PubMed:17499043)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Structural basis for RNA polymerase III transcription repression by Maf1 in humans and yeast has been uncovered., [RefSeq, PubMed]; The human Maf1 protein negatively regulates transcription by all three nuclear Pols. Changes in Maf1 expression affect Pol I- and Pol III-dependent transcription in human glioblastoma lines., [RefSeq, PubMed]; This gene encodes a protein that is similar to Maf1, a Saccharomyces cerevisiae protein highly conserved in eukaryotic cells. Yeast Maf1 is a negative effector of RNA polymerase III (Pol III). It responds to changes in the cellular environment and represses pol III transcription. Biochemical studies identified the initiation factor TFIIIB as a target for Maf1-dependent repression. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "D3DWL4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001002 RNA polymerase III type 1 promoter sequence-specific DNA binding;GO:0001003 RNA polymerase III type 2 promoter sequence-specific DNA binding;GO:0050811 GABA receptor binding;GO:0000994 RNA polymerase III core binding;GO:0001006 RNA polymerase III type 3 promoter sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0016479 negative regulation of transcription by RNA polymerase I;GO:0016480 negative regulation of transcription by RNA polymerase III",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "Q9H063-1",
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    },
    {
        "uniprot_canonical_ac": "Q5SRR4-1",
        "uniprot_id": [
            {
                "id": "LY65C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5SRR4",
                "type": "external"
            }
        ],
        "mass": 16650.0,
        "length": 150,
        "protein_name": "Lymphocyte antigen 6 complex locus protein G5c",
        "gene_name": "LY6G5C",
        "organism": "Human",
        "refseq_name": "lymphocyte antigen 6 complex locus protein G5c precursor",
        "refseq_ac": [
            {
                "id": "NP_079538",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079538",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LY6G5C; C6orf20; G5C; NG33",
        "gene_names_refseq": "C6orf20; G5C; LY6G5CA; LY6G5CB; LY6G5C; NG33",
        "protein_names_uniprotkb": "Lymphocyte antigen 6 complex locus protein G5c",
        "protein_names_refseq": "lymphocyte antigen 6 complex locus protein G5c precursor; lymphocyte antigen 6 complex locus protein G5c; lymphocyte antigen 6 complex, locus G5C; lymphocyte antigen-6 G5C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80741)",
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        "publication_count": 6,
        "publication_id_list": "11237011;12079290;14656967;17008713;18835879;19851445",
        "class_list": "",
        "function": "LY6G5C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]., [RefSeq]; May have a role in hematopoietic cell differentiation., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]",
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "secondary_ac_list": "A6NCW4;B0UXB3;B0UXB4;B0UZ69;B0UZQ0;B1B0L9;O95871;Q5SQ59;Q8NDY0;Q8NDY1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0009897 external side of plasma membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q5SRR4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P26572-1",
        "uniprot_id": [
            {
                "id": "MGAT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P26572",
                "type": "external"
            }
        ],
        "mass": 50878.0,
        "length": 445,
        "protein_name": "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase",
        "gene_name": "MGAT1",
        "organism": "Human",
        "refseq_name": "alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase",
        "refseq_ac": [
            {
                "id": "NP_001108089",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108089",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MGAT1; GGNT1; GLCT1; GLYT1; MGAT",
        "gene_names_refseq": "GLCNAC-TI; GLCT1; GLYT1; GNT-1; GNT-I; GnTI; MGAT1; MGAT",
        "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; 2.4.1.101; GNT-I; GlcNAc-T I; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I",
        "protein_names_refseq": "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase I; alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase; glcNAc-T I; mannosyl (alpha-1,3-)-glycoprotein beta-1,2-N-acetylglucosaminyltransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4245);  (R-HSA-964739);  (R-HSA-9683686);  (R-HSA-9694548)",
        "pathway_count": 4,
        "publication_count": 91,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;11237011;15677381;15760709;1702225;1827260;20129637;20378551;2165493;22915798;23481700;23584533;25348530;25418920;25502872;25576301;25813380;25892735;26154972;27600516;27846572;27920218;28218747;28228285;28467828;28832583;28871256;28904123;29242379;29314611;29393594;29437277;29557506;29632046;29632711;29769354;29786170;30315122;30429286;30459171;30833945;30983867;31154438;31494931;31611695;31844290;31848261;31998317;32157095;32161166;32350084;32357974;32363391;32366695;32387766;32488085;32518941;32676595;32763972;32938616;32983136;33043033;33123756;33310888;3346233;33592498;33717175;33912179;33936100;33968037;34117209;34171305;34357683;34428449;34433824;34528721;34599882;34932366;34961524;35051231;35154160;35251023;35580925;36280670;36284347;37938771;39081317;40307207;40914422;7986008",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Elucidating the multifaceted role of MGAT1 in hepatocellular carcinoma: integrative single-cell and spatial transcriptomics reveal novel therapeutic insights. Publication Status: Online-Only, [RefSeq, PubMed]; Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; MGAT1 promotes complex N-glycosylation of glucose transporter 1 (Glut1) and increases Glut1 protein levels. In summary, our findings indicate that MGAT1 is highly expressed in glioblastoma and promotes glioma cells at least partly through upregulation of Glut1 protein., [RefSeq, PubMed]; Point mutations that inactivate MGAT4D-L, an inhibitor of MGAT1 and complex N-glycan synthesis., [RefSeq, PubMed]; There are believed to be over 100 different glycosyltransferases involved in the synthesis of protein-bound and lipid-bound oligosaccharides. UDP-N-acetylglucosamine:alpha-3-D-mannoside beta-1,2-N-acetylglucosaminyltransferase I is a medial-Golgi enzyme essential for the synthesis of hybrid and complex N-glycans. The protein, encoded by a single exon, shows typical features of a type II transmembrane protein. The protein is believed to be essential for normal embryogenesis. Several variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 575,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K404;B3KRU8;D3DWR1;Q6IBE3",
        "ec_number_list": [
            {
                "id": "2.4.1.101",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.101",
                "type": "external"
            },
            {
                "id": "2.4.1.143",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.143",
                "type": "external"
            },
            {
                "id": "3.2.1.114",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.114",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0030145 manganese ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0003827 alpha-1,3-mannosylglycoprotein 2-beta-N-acetylglucosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0019082 viral protein processing;GO:0006487 protein N-linked glycosylation;GO:0009101 glycoprotein biosynthetic process",
        "synthesized_glycan_count": 9485,
        "hit_score": 10.3,
        "record_id": "P26572-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.100.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WVP7-1",
        "uniprot_id": [
            {
                "id": "LMBR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WVP7",
                "type": "external"
            }
        ],
        "mass": 55098.0,
        "length": 490,
        "protein_name": "Limb region 1 protein homolog",
        "gene_name": "LMBR1",
        "organism": "Human",
        "refseq_name": "limb region 1 protein homolog isoform b",
        "refseq_ac": [
            {
                "id": "NP_071903",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071903",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LMBR1; C7orf2; DIF14",
        "gene_names_refseq": "ACHP; C7orf2; DIF14; LMBR1; PPD2; THYP; TPTPS; TPT; ZRS",
        "protein_names_uniprotkb": "Limb region 1 protein homolog; Differentiation-related gene 14 protein",
        "protein_names_refseq": "differentiation-related gene 14 protein; limb region 1 homolog; limb region 1 protein homolog isoform b; limb region 1 protein homolog",
        "tax_id": 9606,
        "disease": "acheiropody (Disease Ontology:DOID:0050603); preaxial polydactyly II (Disease Ontology:DOID:0060986); bone development disease (Disease Ontology:DOID:0080006); Laurin-Sandrow syndrome (Disease Ontology:DOID:0111350); hypoplastic or aplastic tibia with polydactyly (Disease Ontology:DOID:0111564); syndactyly type 4 (Disease Ontology:DOID:0111818); triphalangeal thumb-polysyndactyly syndrome (MONDO:MONDO:0017454)",
        "pathway": " (hsa:64327)",
        "pathway_count": 1,
        "publication_count": 37,
        "publication_id_list": "10329000;11090342;11237011;12837695;18417549;19847792;24456159;24777739;24965254;26992070;28228285;28832583;28834231;28904123;29242379;29393594;30315122;31395945;31844290;32157095;32179704;32357974;32387766;32502341;32662247;32938616;33912179;33936100;33968037;34171305;34211107;34509645;35051231;35318648;35580925;36241641;39190381",
        "class_list": "",
        "function": "Large duplication in LMBR1 gene in a large Chinese pedigree with triphalangeal thumb polysyndactyly syndrome., [RefSeq, PubMed]; PAR1 Activation, via LMBR1/BMP Axis, Promotes the Osteogenesis of Periodontal Ligament Stem Cells (PDLSCs) and Alleviates the Inhibitory Effect of Sodium Butyrate on PDLSCs Osteogenesis., [RefSeq, PubMed]; Putative membrane receptor., [UniProtKB]; Results identify a novel g.101779T>A variant segregating with all individuals affected with preaxial polydactyly type 1(PPDI)., [RefSeq, PubMed]; This gene encodes a member of the LMBR1-like membrane protein family. Another member of this protein family has been shown to be a lipocalin transmembrane receptor. A highly conserved, cis-acting regulatory module for the sonic hedgehog gene is located within an intron of this gene. Consequently, disruption of this genic region can alter sonic hedgehog expression and affect limb patterning, but it is not known if this gene functions directly in limb development. Mutations and chromosomal deletions and rearrangements in this genic region are associated with acheiropody and preaxial polydactyly, which likely result from altered sonic hedgehog expression. [provided by RefSeq, Jul 2008]., [RefSeq]; Variable expression of subclinical phenotypes instead of reduced penetrance in families with mild triphalangeal thumb phenotypes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D242;Q8N3E3;Q96QZ5;Q9H5N0;Q9HAG9;Q9UDN5;Q9Y6U2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "Q8WVP7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z304-1",
        "uniprot_id": [
            {
                "id": "MAMC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z304",
                "type": "external"
            }
        ],
        "mass": 77556.0,
        "length": 686,
        "protein_name": "MAM domain-containing protein 2",
        "gene_name": "MAMDC2",
        "organism": "Human",
        "refseq_name": "MAM domain-containing protein 2 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_694999",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694999",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAMDC2",
        "gene_names_refseq": "MAMDC2",
        "protein_names_uniprotkb": "MAM domain-containing protein 2; MAM domain-containing proteoglycan; Mamcan",
        "protein_names_refseq": "MAM domain-containing protein 2 isoform 1 precursor; MAM domain-containing protein 2; MAM domain-containing proteoglycan; mamcan",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:256691)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;23481700;23584533;29557506;30429286;30779550;32157095;32387766;32707597;33968037;35051231;36241641;37503746",
        "class_list": "",
        "function": "Ablation of the carboxy-terminal end of MAMDC2 causes a distinct muscular dystrophy., [RefSeq, PubMed]; MAM domain containing 2 is a potential breast cancer biomarker that exhibits tumour-suppressive activity., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VW47;Q8WX43;Q96BM4",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q7Z304-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14807-1",
        "uniprot_id": [
            {
                "id": "KIF22_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14807",
                "type": "external"
            }
        ],
        "mass": 73262.0,
        "length": 665,
        "protein_name": "Kinesin-like protein KIF22",
        "gene_name": "KIF22",
        "organism": "Human",
        "refseq_name": "kinesin-like protein KIF22 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001243198",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243198",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KIF22; KID; KNSL4",
        "gene_names_refseq": "A-328A3.2; KID; KIF22; KNSL4; OBP-1; OBP-2; OBP; SEMDJL2",
        "protein_names_uniprotkb": "Kinesin-like protein KIF22; Kinesin-like DNA-binding protein; Kinesin-like protein 4",
        "protein_names_refseq": "kinesin-like DNA-binding protein pseudogene; kinesin-like protein 4; kinesin-like protein KIF22 isoform 2; oriP binding protein; origin of plasmid DNA replication-binding protein",
        "tax_id": 9606,
        "disease": "spondyloepiphyseal dysplasia with congenital joint dislocations (Disease Ontology:DOID:0050813); spondyloepimetaphyseal dysplasia with joint laxity type 2 (Disease Ontology:DOID:0112199)",
        "pathway": " (hsa:3835);  (R-HSA-2132295);  (R-HSA-6811434);  (R-HSA-983189)",
        "pathway_count": 4,
        "publication_count": 259,
        "publication_id_list": "10036229;10052452;10064083;10072072;10318838;10445031;10480952;10540230;10559959;10593899;10631941;10631952;10639150;10748235;10761932;10809954;10921873;11146551;11172815;11237011;11493604;11529500;11684289;11689559;11703931;11726511;11739780;11748249;11782313;11790530;11813165;11853874;12047556;12070132;12078484;12198549;12368902;12727876;12742663;12748383;1406973;14504276;14654841;14731593;15029241;15037235;15272311;15326200;15616190;15632110;15749704;15813748;15911768;16030262;1607388;16181339;16242130;16262723;1631136;16565220;16571679;16618111;16633337;1680566;16824007;16912714;16926190;16940185;17113389;17142755;17253781;17283181;17346968;17360540;17429068;17451557;17525332;17538014;17760859;17927562;17956946;18046453;18182008;18287528;18292509;18342609;18452278;18485706;18524849;18669648;18809720;1898986;19007248;19015319;19109418;19116309;19151722;19164740;19338388;19369418;1956401;19564404;1957170;19631211;19664995;19690332;19691289;19758564;20005805;20068231;20112406;20136777;20357002;20427317;20462495;20534429;20637885;21116285;2121367;21219331;2142332;21441454;21550981;21689688;21844168;2190094;22013193;22094269;22152677;22152678;22304919;22898188;23186163;23396477;23481700;2391366;24397554;24715725;2521221;2522352;25364732;25436559;25469497;25492864;25505266;25576301;25743205;25892735;26154972;26811146;26992070;27846572;27862975;27920218;28228285;28832583;28834231;28855257;28904123;29242379;29493099;29557506;29769354;29786170;30315122;30358852;30379171;30429286;31217245;3130248;3134048;31657617;31844290;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34509645;34932366;35051231;35154160;35318648;35561310;35578724;35580925;35730929;36010968;36215666;36241641;36284347;37944197;38713252;40596516;7481823;7528108;7539720;7592972;7650016;7667286;7822426;7844144;7929562;8001155;8046351;8128252;8132710;8134367;8145819;8148318;8221884;8253837;8313912;8397411;8415765;8505331;8548803;8599929;8602245;8620540;8642258;8687433;8849454;8909537;8939989;8947036;9075930;9114004;9177194;9202021;9244307;9288971;9311912;9312039;9405360;9497313;9539769;9545226;9606180;9751720;9790757;9990005",
        "class_list": "",
        "function": "KIF22 Promotes Development of Pancreatic Cancer by Regulating the MEK/ERK/P21 Signaling Axis. Publication Status: Online-Only, [RefSeq, PubMed]; KIF22 promotes multiple myeloma progression by regulating the CDC25C/CDK1/cyclinB1 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; KIF22 promotes the proliferation and glycolysis of melanoma by activating EGFR/STAT3 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Kinesin family member that is involved in spindle formation and the movements of chromosomes during mitosis and meiosis. Binds to microtubules and to DNA (By similarity). Plays a role in congression of laterally attached chromosomes in NDC80-depleted cells (PubMed:25743205)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Suppression of KIF22 Inhibits Cell Proliferation and Xenograft Tumor Growth in Colon Cancer., [RefSeq, PubMed]; The protein encoded by this gene is a member of the kinesin-like protein family. The family members are microtubule-dependent molecular motors that transport organelles within cells and move chromosomes during cell division. The C-terminal half of this protein has been shown to bind DNA. Studies with the Xenopus homolog suggests its essential role in metaphase chromosome alignment and maintenance. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2012]., [RefSeq]; We identified two candidate mutations in COL1A2 and MATN1, which might be affected by the main known mutation in B3GALT6.  Our finding replicated a previously identified mutation in KIF22 to be potentially associated with spondyloepimetaphyseal dysplasia with joint laxity. We also show that our identified candidate mutation genes, COL1A2, MATN1 and KIF22, are in a direct biological interaction with B3GALT6., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5M0;B7Z265;O60845;O94814;Q53F58;Q9BT46",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0003777 microtubule motor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0016607 nuclear speck",
        "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0000278 mitotic cell cycle;GO:0006281 DNA repair;GO:0007018 microtubule-based movement;GO:0007080 mitotic metaphase chromosome alignment",
        "synthesized_glycan_count": 0,
        "hit_score": 26.2,
        "record_id": "Q14807-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6P1A2-1",
        "uniprot_id": [
            {
                "id": "MBOA5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P1A2",
                "type": "external"
            }
        ],
        "mass": 56035.0,
        "length": 487,
        "protein_name": "Lysophospholipid acyltransferase 5",
        "gene_name": "LPCAT3",
        "organism": "Human",
        "refseq_name": "lysophospholipid acyltransferase 5",
        "refseq_ac": [
            {
                "id": "NP_005759",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005759",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LPCAT3; MBOAT5; OACT5",
        "gene_names_refseq": "C3F; LPCAT3; LPCAT; LPLAT 5; LPLAT12; LPSAT; MBOAT5; OACT5; nessy",
        "protein_names_uniprotkb": "Lysophospholipid acyltransferase 5; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase; 2.3.1.-; 2.3.1.23; 2.3.1.n6; 2.3.1.n7; LPCAT; LPLAT 5; LPSAT; Lyso-PC acyltransferase 3; Lyso-PC acyltransferase; Lyso-PS acyltransferase; Lysophosphatidylcholine acyltransferase 3; Lysophosphatidylcholine acyltransferase; Lysophosphatidylserine acyltransferase; Membrane-bound O-acyltransferase domain-containing protein 5; O-acyltransferase domain-containing protein 5",
        "protein_names_refseq": "1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase; O-acyltransferase (membrane bound) domain containing 5; O-acyltransferase domain-containing protein 5; lyso-PC acyltransferase 3; lyso-PS acyltransferase; lysophosphatidylserine acyltransferase; lysophospholipid acyltransferase 12; lysophospholipid acyltransferase 5; membrane bound O-acyltransferase domain containing 5; membrane-bound O-acyltransferase domain-containing protein 5; putative protein similar to nessy",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10162);  (R-HSA-1482788);  (R-HSA-1482801);  (R-HSA-1482839)",
        "pathway_count": 4,
        "publication_count": 125,
        "publication_id_list": "10085124;10092647;10196188;10336645;10358058;10455175;10681567;11031251;11112443;11237011;11830583;12150957;12161451;12359733;12522102;14709560;15695510;15863501;15944408;1618844;16243729;16617059;16704971;16818490;16864775;17101204;17182612;18195019;18287005;18458083;18614531;18772128;18781350;18782225;19019078;1904318;19351971;19501189;19554302;20068231;20705608;21220512;21515882;22605381;22825852;22906437;23481700;23934110;24715725;25576301;25645385;25892735;26154972;26206935;26375851;26463208;26503625;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28832583;28860189;28904123;29242379;2925608;2925633;29393594;29437277;29508533;29557506;29632046;29632711;29769354;29786170;30410026;30429286;30524438;31217245;31844290;32157095;32357974;32387766;32488085;32502341;32780898;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33912179;33968037;33981976;34087483;34211107;34357683;34405274;34509645;34561969;34725712;35051231;35154160;35286868;35580925;36010968;36215666;36241641;36284347;37166352;37938771;38073444;38519981;7060561;8083230;8300559;9074930;9188469;9417066;9705332",
        "class_list": "",
        "function": "Hyperuricemia induces lipid disturbances mediated by LPCAT3 upregulation in the liver., [RefSeq, PubMed]; Inhibition of the MALT1-LPCAT3 axis protects cartilage degeneration and osteoarthritis. Publication Status: Online-Only, [RefSeq, PubMed]; LPCAT3 Is Transcriptionally Regulated by YAP/ZEB/EP300 and Collaborates with ACSL4 and YAP to Determine Ferroptosis Sensitivity., [RefSeq, PubMed]; LPCAT3 is primarily responsible for hepatic LPCAT activity, [RefSeq, PubMed]; Lysophospholipid O-acyltransferase (LPLAT) that catalyzes the reacylation step of the phospholipid remodeling process also known as the Lands cycle (PubMed:18195019, PubMed:18772128, PubMed:18782225). Catalyzes transfer of the fatty acyl chain from fatty acyl-CoA to 1-acyl lysophospholipid to form various classes of phospholipids. Converts 1-acyl lysophosphatidylcholine (LPC) into phosphatidylcholine (PC) (LPCAT activity), 1-acyl lysophosphatidylserine (LPS) into phosphatidylserine (PS) (LPSAT activity) and 1-acyl lysophosphatidylethanolamine (LPE) into phosphatidylethanolamine (PE) (LPEAT activity) (PubMed:18195019, PubMed:18772128, PubMed:18782225). Favors polyunsaturated fatty acyl-CoAs as acyl donors compared to saturated fatty acyl-CoAs (PubMed:18195019, PubMed:18772128). Has higher activity for LPC acyl acceptors compared to LPEs and LPSs. Can also transfer the fatty acyl chain from fatty acyl-CoA to 1-O-alkyl lysophospholipid or 1-O-alkenyl lysophospholipid with lower efficiency (By similarity). Acts as a major LPC O-acyltransferase in liver and intestine. As a component of the liver X receptor/NR1H3 or NR1H2 signaling pathway, mainly catalyzes the incorporation of arachidonate into PCs of endoplasmic reticulum (ER) membranes, increasing membrane dynamics and enabling triacylglycerols transfer to nascent very low-density lipoprotein (VLDL) particles. Promotes processing of sterol regulatory protein SREBF1 in hepatocytes, likely by facilitating the translocation of SREBF1-SCAP complex from ER to the Golgi apparatus (By similarity). Participates in mechanisms by which the liver X receptor/NR1H3 or NR1H2 signaling pathway counteracts lipid-induced ER stress response and inflammation. Down-regulates hepatic inflammation by limiting arachidonic acid availability for synthesis of inflammatory eicosanoids, such as prostaglandins (By similarity). In enterocytes, acts as a component of a gut-brain feedback loop that coordinates dietary lipid absorption and food intake. Regulates the abundance of PCs containing linoleate and arachidonate in enterocyte membranes, enabling passive diffusion of fatty acids and cholesterol across the membrane for efficient chylomicron assembly (By similarity). In the intestinal crypt, acts as a component of dietary-responsive phospholipid-cholesterol axis, regulating the biosynthesis of cholesterol and its mitogenic effects on intestinal stem cells (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Methylation Regulation of LPCAT3 Improves Osteoarthritis by Regulating ACSL4 to Inhibit Chondrocyte Ferroptosis., [RefSeq, PubMed]; The regulation of LPCAT3 by miR-124-3p.1 in acute kidney injury suppresses cell proliferation by disrupting phospholipid metabolism., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDH0;B7Z3N3;Q7KZS1;Q92980;Q9BW40",
        "ec_number_list": [
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.121",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.121",
                "type": "external"
            },
            {
                "id": "2.3.1.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67",
                "type": "external"
            },
            {
                "id": "2.3.1.n6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6",
                "type": "external"
            },
            {
                "id": "2.3.1.n7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            },
            {
                "id": "2.3.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity;GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0071617 lysophospholipid acyltransferase activity;GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:0090158 endoplasmic reticulum membrane organization;GO:0045540 regulation of cholesterol biosynthetic process;GO:0050728 negative regulation of inflammatory response;GO:0006656 phosphatidylcholine biosynthetic process;GO:0034379 very-low-density lipoprotein particle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 12.8,
        "record_id": "Q6P1A2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NSB8-1",
        "uniprot_id": [
            {
                "id": "HOME2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NSB8",
                "type": "external"
            }
        ],
        "mass": 40627.0,
        "length": 354,
        "protein_name": "Homer protein homolog 2",
        "gene_name": "HOMER2",
        "organism": "Human",
        "refseq_name": "homer protein homolog 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_004830",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004830",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HOMER2",
        "gene_names_refseq": "ACPD; CPD; DFNA68; HOMER-2; HOMER2; VESL-2",
        "protein_names_uniprotkb": "Homer protein homolog 2; Cupidin; Homer-2",
        "protein_names_refseq": "cupidin; homer homolog 2; homer homolog 3; homer protein homolog 2 isoform 1; homer protein homolog 2; homer scaffolding protein 2; homer, neuronal immediate early gene, 2",
        "tax_id": 9606,
        "disease": "autosomal dominant nonsyndromic deafness 68 (Disease Ontology:DOID:0110589); alcohol use disorder (Disease Ontology:DOID:1574); temporal lobe epilepsy (Disease Ontology:DOID:3328); muscular atrophy (Disease Ontology:DOID:767); cocaine abuse (Disease Ontology:DOID:809); cocaine dependence (Disease Ontology:DOID:9975)",
        "pathway": " (hsa:9455);  (R-HSA-6794361)",
        "pathway_count": 2,
        "publication_count": 45,
        "publication_id_list": "10653696;11237011;11604393;15540461;16242404;16624946;16846852;17897391;18218901;18812509;18829961;20064387;20064388;20519524;21282647;25378172;25576301;25816005;28411811;28832583;29493099;29891190;30047143;30379171;31154438;31530632;31844290;32157095;32387766;32502341;32938616;32983136;33809266;34509645;35051231;35254053;36010968;37173411;7695896;7736595;8576240;9069287;9808458;9808459;9927700",
        "class_list": "",
        "function": "A Novel Truncating Mutation in HOMER2 Causes Nonsyndromic Progressive DFNA68 Hearing Loss in a Spanish Family. Publication Status: Online-Only, [RefSeq, PubMed]; Identification and in vivo functional investigation of a HOMER2 nonstop variant causing hearing loss., [RefSeq, PubMed]; Postsynaptic density scaffolding protein. Binds and cross-links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER-associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2. Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (PubMed:9808459). Required for normal hearing (PubMed:25816005). Negatively regulates T cell activation by inhibiting the calcineurin-NFAT pathway. Acts by competing with calcineurin/PPP3CA for NFAT protein binding, hence preventing NFAT activation by PPP3CA (PubMed:18218901)., [UniProtKB, PubMed, PubMed, PubMed]; That HOMER2 may be involved in tumourigenesis of endometrioid uterine tumours, [RefSeq, PubMed]; This gene encodes a member of the homer family of dendritic proteins. Members of this family regulate group 1 metabotrophic glutamate receptor function. The encoded protein is a postsynaptic density scaffolding protein. Alternative splicing results in multiple transcript variants. Two related pseudogenes have been identified on chromosome 14. [provided by RefSeq, Jun 2011]., [RefSeq]; We have identified a distinct, novel insertion variant in HOMER2, which provides validating evidence that HOMER2 is indeed required for normal hearing. Its sequence alteration is responsible for late-onset, autosomal dominant, non-syndromic, SNHL in humans., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 6,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95269;O95349;Q9NSB6;Q9NSB7;Q9UNT7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0035256 G protein-coupled glutamate receptor binding;GO:0003779 actin binding;GO:0030160 synaptic receptor adaptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0014069 postsynaptic density",
        "go_biological_process": "GO:0032703 negative regulation of interleukin-2 production;GO:0007605 sensory perception of sound;GO:0070885 negative regulation of calcineurin-NFAT signaling cascade;GO:0051966 regulation of synaptic transmission, glutamatergic;GO:2001256 regulation of store-operated calcium entry",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q9NSB8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00515-1",
        "uniprot_id": [
            {
                "id": "LAD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00515",
                "type": "external"
            }
        ],
        "mass": 57131.0,
        "length": 517,
        "protein_name": "Ladinin-1",
        "gene_name": "LAD1",
        "organism": "Human",
        "refseq_name": "ladinin-1",
        "refseq_ac": [
            {
                "id": "NP_005549",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005549",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LAD1; LAD",
        "gene_names_refseq": "LAD1; LadA",
        "protein_names_uniprotkb": "Ladinin-1; LADA; Lad-1; Linear IgA disease antigen",
        "protein_names_refseq": "lad-1; ladinin-1; linear IgA bullous dermatosis antigen; linear IgA disease antigen homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3898)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;16083285;19664995;20166139;21406692;24129315;24275569;25576301;29382783;29557506;31154438;33141586;34087483;34516317;35051231;35580925;36284347;36613882;36770773;39354061",
        "class_list": "",
        "function": "Anchoring filament protein which is a component of the basement membrane zone., [UniProtKB, UniProtKB, UniProtKB]; High abundance of LAD1 is associated with breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; High expression of ladinin-1 (LAD1) predicts adverse outcomes: a new candidate docetaxel resistance gene for prostatic cancer (PCa)., [RefSeq, PubMed]; Ladinin 1 Shortens Survival via Promoting Proliferation and Enhancing Invasiveness in Lung Adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Ladinin-1 in actin arcs of oral squamous cell carcinoma is involved in cell migration and epithelial phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; The Tumorigenic Effect of the High Expression of Ladinin-1 in Lung Adenocarcinoma and Its Potential as a Therapeutic Target. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene may be an anchoring filament that is a component of basement membranes. It may contribute to the stability of the association of the epithelial layers with the underlying mesenchyme. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95614;Q96GD8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005198 structural molecule activity;GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0015629 actin cytoskeleton;GO:0070062 extracellular exosome;GO:0005604 basement membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "O00515-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A8MXZ3-1",
        "uniprot_id": [
            {
                "id": "KRA91_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A8MXZ3",
                "type": "external"
            }
        ],
        "mass": 26333.0,
        "length": 250,
        "protein_name": "Keratin-associated protein 9-1",
        "gene_name": "KRTAP9-1",
        "organism": "Human",
        "refseq_name": "keratin-associated protein 9-1",
        "refseq_ac": [
            {
                "id": "NP_001177389",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001177389",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KRTAP9-1; KAP9.1; KRTAP9.1; KRTAP9L3",
        "gene_names_refseq": "KAP9.1; KRTAP9-1; KRTAP9L3",
        "protein_names_uniprotkb": "Keratin-associated protein 9-1; Keratin-associated protein 9-like 3",
        "protein_names_refseq": "keratin associated protein 9-like 3; keratin-associated protein 9-1; putative keratin-associated protein 9-2-like 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:728318);  (R-HSA-6805567)",
        "pathway_count": 2,
        "publication_count": 10,
        "publication_id_list": "15373777;16382671;1691188;1694855;1714783;17521629;23481192;2414304;25208914;9468612",
        "class_list": "",
        "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "record_id": "A8MXZ3-1",
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    },
    {
        "uniprot_canonical_ac": "Q9H1C4-1",
        "uniprot_id": [
            {
                "id": "UN93B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H1C4",
                "type": "external"
            }
        ],
        "mass": 66631.0,
        "length": 597,
        "protein_name": "Protein unc-93 homolog B1",
        "gene_name": "UNC93B1",
        "organism": "Human",
        "refseq_name": "protein unc-93 homolog B1",
        "refseq_ac": [
            {
                "id": "NP_112192",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112192",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UNC93B1; UNC93B; UNC93",
        "gene_names_refseq": "IIAE1; UNC-93B; UNC93B1; UNC93B; UNC93; Unc-93B1",
        "protein_names_uniprotkb": "Protein unc-93 homolog B1; Unc-93B1; hUNC93B1",
        "protein_names_refseq": "protein unc-93 homolog B1; unc-93 homolog B1, TLR signaling regulator; unc-93 related protein; unc93 homolog B1",
        "tax_id": 9606,
        "disease": "brain disease (Disease Ontology:DOID:936); herpes simplex encephalitis, susceptibility to, 1 (MONDO:MONDO:0024563)",
        "pathway": " (hsa:81622);  (R-HSA-1679131);  (R-HSA-5602415)",
        "pathway_count": 3,
        "publication_count": 103,
        "publication_id_list": "11237011;11867227;14716310;15226270;16111919;16415873;16857668;16973841;17081983;17275357;17452530;18082565;18166152;18305481;18509083;18669648;18820679;18931679;18991276;19006693;19079358;19369195;19415658;19451267;19651622;19965672;20855885;20865800;21398612;21402738;21604257;21642595;22164301;22223641;22544926;23103873;23186163;24190977;24715725;24778236;25502872;25505266;25576301;26154972;26992070;27846572;27862975;28904123;29437277;29493099;29557506;30315122;30429286;30779550;30833945;31154438;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33432245;33537174;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34357683;34405274;34433824;34509645;34932366;35051231;35154160;35318648;35577759;35580925;35874766;36010968;36241641;36284347;37938771;38207055;38780621;38831104;38869500;8344253;9799232",
        "class_list": "",
        "function": "Findings elucidate a genetic etiology for herpes simplex virus encephalitis in two children with autosomal recessive deficiency in the intracellular protein UNC-93B, resulting in impaired cellular interferon-alpha/beta and -lambda antiviral responses, [RefSeq, PubMed]; Gain-of-function human UNC93B1 variants cause systemic lupus erythematosus and chilblain lupus., [RefSeq, PubMed]; Genetic variants in UNC93B1 predispose to childhood-onset systemic lupus erythematosus. Erratum:[Nat Immunol. 2024 Oct;25(10):1977. doi: 10.1038/s41590-024-01969-9. PMID: 39251802], [RefSeq, PubMed]; Haplotype H3 of the hUNC-93B1 gene seems related to E/A-ratio in elderly men. The relationship between the hUNC-93B1 gene and the age at onset of heart failure and mortality support a view of a clinically relevant impact of the gene., [RefSeq, PubMed]; Large-scale mutational analysis identifies UNC93B1 variants that drive TLR-mediated autoimmunity in mice and humans., [RefSeq, PubMed]; Plays an important role in innate and adaptive immunity by regulating nucleotide-sensing Toll-like receptor (TLR) signaling. Required for the transport of a subset of TLRs (including TLR3, TLR7 and TLR9) from the endoplasmic reticulum to endolysosomes where they can engage pathogen nucleotides and activate signaling cascades. May play a role in autoreactive B-cells removal., [UniProtKB, PubMed]; Study confirms the function of UNC-93B for innate immunity in human beings, and extends the knowledge for this molecule to the analysis of its regulation and the subcellular localization of the endogenous protein, [RefSeq, PubMed]; This gene encodes a protein that is involved in innate and adaptive immune response by regulating toll-like receptor signaling. The encoded protein traffics nucleotide sensing toll-like receptors to the endolysosome from the endoplasmic reticulum. Deficiency of the encoded protein has been associated with herpes simplex encephalitis. [provided by RefSeq, Feb 2014]., [RefSeq]; UNC93B1 attenuates the cGAS-STING signaling pathway by targeting STING for autophagy-lysosome degradation., [RefSeq, PubMed]; UNC93B1 variants underlie TLR7-dependent autoimmunity., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "O95764;Q569H6;Q710D4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0035325 Toll-like receptor binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005783 endoplasmic reticulum;GO:0005764 lysosome;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0002250 adaptive immune response;GO:0002224 toll-like receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "Q9H1C4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000100010001.111.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H992-1",
        "uniprot_id": [
            {
                "id": "MARH7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H992",
                "type": "external"
            }
        ],
        "mass": 78051.0,
        "length": 704,
        "protein_name": "E3 ubiquitin-protein ligase MARCHF7",
        "gene_name": "MARCHF7",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase MARCHF7 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001269735",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269735",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MARCHF7; AXOT; MARCH7; RNF177",
        "gene_names_refseq": "AXOT; AXO; MARCH-VII; MARCH7; MARCHF7; RNF177",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF7; 2.3.2.27; Axotrophin; MARCH-VII; Membrane-associated RING finger protein 7; Membrane-associated RING-CH protein VII; RING finger protein 177; RING-type E3 ubiquitin transferase MARCHF7",
        "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH7; E3 ubiquitin-protein ligase MARCHF7 isoform b; E3 ubiquitin-protein ligase MARCHF7; RING finger protein 177; RING-type E3 ubiquitin transferase MARCH7; RING-type E3 ubiquitin transferase MARCHF7; axotrophin; membrane associated ring finger 7; membrane-associated RING finger protein 7; membrane-associated RING-CH protein VII; membrane-associated ring finger (C3HC4) 7, E3 ubiquitin protein ligase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64844)",
        "pathway_count": 1,
        "publication_count": 99,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15670816;16868077;17161353;18077418;18669648;19664994;21872626;23186163;23481700;23783831;24366607;24397554;24714562;24715725;25418920;25576301;25594175;25880248;25892735;26154972;26375851;26728094;26992070;27600516;27846572;27920218;28063628;28228285;28514659;28832583;28834231;28860189;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30315122;30379171;30410026;30429286;30484775;30779550;30833945;31154438;31217245;31270356;31530632;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33091337;33141586;33298915;33392160;33592498;33691108;33717175;33729124;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34509645;34561969;34725712;34932366;35051231;35318648;35561310;35580925;36010968;36241641;36284347;36583798;37217939;37632749;37915253;37938771",
        "class_list": "",
        "function": "Association of MARCH7 with tumor progression and T-cell infiltration in esophageal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Control of ATG14 solubility and autophagy by MARCHF7/MARCH7-mediated ubiquitination., [RefSeq, PubMed]; Data suggest that clinical auto-graft versus host disease inversely correlates with axotrophin transcript expression., [RefSeq, PubMed]; E3 ubiquitin-protein ligase which may specifically enhance the E2 activity of HIP2. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates (PubMed:16868077). May be involved in T-cell proliferation by regulating LIF secretion (By similarity). May play a role in lysosome homeostasis (PubMed:31270356). Promotes 'Lys-6', 'Lys-11' and 'Lys-63'-linked mixed polyubiquitination on ATG14 leading to the inhibition of autophagy by impairing the interaction between ATG14 and STX7 (PubMed:37632749). Participates in the dopamine-mediated negative regulation of the NLRP3 inflammasome by promoting its ubiquitination and subsequent degradation (PubMed:25594175)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Identification of novel interactions between host and non-structural protein 2C of foot-and-mouth disease virus., [RefSeq, PubMed]; MARCH7 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH proteins add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments (Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "A8K9X1;B7Z7P5;D3DPB0;Q53GQ1;Q9BTR9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0043130 ubiquitin binding;GO:0097371 MDM2/MDM4 family protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0008284 positive regulation of cell population proliferation;GO:0050821 protein stabilization;GO:0051865 protein autoubiquitination;GO:0043518 negative regulation of DNA damage response, signal transduction by p53 class mediator",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "Q9H992-1",
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    },
    {
        "uniprot_canonical_ac": "A4D2B0-1",
        "uniprot_id": [
            {
                "id": "MBLC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A4D2B0",
                "type": "external"
            }
        ],
        "mass": 27202.0,
        "length": 266,
        "protein_name": "Metallo-beta-lactamase domain-containing protein 1",
        "gene_name": "MBLAC1",
        "organism": "Human",
        "refseq_name": "metallo-beta-lactamase domain-containing protein 1",
        "refseq_ac": [
            {
                "id": "NP_981942",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_981942",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MBLAC1",
        "gene_names_refseq": "MBLAC1",
        "protein_names_uniprotkb": "Metallo-beta-lactamase domain-containing protein 1; 3.1.27.-; Endoribonuclease MBLAC1",
        "protein_names_refseq": "endoribonuclease MBLAC1; metallo-beta-lactamase domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:255374)",
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        "publication_count": 5,
        "publication_id_list": "11237011;20068231;30507380;31092671;33592498",
        "class_list": "",
        "function": "Endoribonuclease that catalyzes the hydrolysis of histone-coding pre-mRNA 3'-end. Involved in histone pre-mRNA processing during the S-phase of the cell cycle, which is required for entering/progressing through S-phase (PubMed:30507380). Cleaves histone pre-mRNA at a major and a minor cleavage site after the 5'-ACCCA-3' and the 5'-ACCCACA-3' sequence, respectively, and located downstream of the stem-loop (PubMed:30507380). May require the presence of the HDE element located at the histone pre-RNA 3'-end to avoid non-specific cleavage (PubMed:30507380)., [UniProtKB, PubMed]; The cellular, genetic, biochemical, substrate selectivity, and crystallographic studies have been reported providing evidence that endoribonuclease, MBLAC1, is selective for 3' processing of replication-dependent histone pre-mRNA during the S-phase of the cell cycle. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q8N5X8",
        "ec_number_list": [
            {
                "id": "3.1.27.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.27.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016787 hydrolase activity;GO:0046872 metal ion binding;GO:0004521 RNA endonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:1900087 positive regulation of G1/S transition of mitotic cell cycle;GO:0031124 mRNA 3'-end processing;GO:0008334 histone mRNA metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A4D2B0-1",
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    },
    {
        "uniprot_canonical_ac": "P27918-1",
        "uniprot_id": [
            {
                "id": "PROP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P27918",
                "type": "external"
            }
        ],
        "mass": 51276.0,
        "length": 469,
        "protein_name": "Properdin",
        "gene_name": "CFP",
        "organism": "Human",
        "refseq_name": "properdin precursor",
        "refseq_ac": [
            {
                "id": "NP_001138724",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138724",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CFP; PFC",
        "gene_names_refseq": "BFD; CFP; PFC; PFD; PROPERDIN",
        "protein_names_uniprotkb": "Properdin; Complement factor P",
        "protein_names_refseq": "complement factor P; properdin P factor, complement; properdin precursor",
        "tax_id": 9606,
        "disease": "X-linked properdin deficiency (Disease Ontology:DOID:0111768); factor VIII deficiency (Disease Ontology:DOID:12134)",
        "pathway": " (hsa:5199);  (R-HSA-173736);  (R-HSA-174577);  (R-HSA-5083635);  (R-HSA-5173214);  (R-HSA-6798695);  (R-HSA-977606)",
        "pathway_count": 7,
        "publication_count": 102,
        "publication_id_list": "10531307;1067618;10878002;10909851;11067851;11237011;11694537;11939578;12055245;12096136;12878586;1386357;1417780;1431505;15199963;15491616;16079145;16192651;16301317;16335952;16464858;16959974;16999828;17182573;17505110;17989688;18720094;19139490;19796186;2009915;20382442;21788512;22588082;22802338;23090970;23487775;23650620;23889335;2420889;2465906;2466593;2481448;25544610;268620;279011;28264884;29242379;293688;293746;29557506;2956252;29649283;2971659;301546;3052276;31507604;32065623;32350084;33240263;33298915;33494138;3421908;35031611;35051231;35580925;35843030;36127336;3848661;4098172;6214588;6219696;6222381;6230668;6238120;6334079;6454142;6607952;6707020;670886;6906228;6912277;702059;7391570;7542572;760802;761607;7690834;7691959;809512;82604;8345200;8495193;8530058;8692836;8786315;8871668;9038722;9171898;950465;9710744;9748277;978134",
        "class_list": "",
        "function": "A positive regulator of the alternate pathway (AP) of complement (PubMed:16301317, PubMed:20382442, PubMed:28264884, PubMed:9748277). It binds to and stabilizes the C3- and C5-convertase enzyme complexes (PubMed:16301317, PubMed:20382442, PubMed:28264884, PubMed:9748277). Inhibits CFI-CFH mediated degradation of Complement C3 beta chain (C3b) (PubMed:31507604)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Properdin Is a Modulator of Tumour Immunity in a Syngeneic Mouse Melanoma Model. Publication Status: Online-Only, [RefSeq, PubMed]; Properdin produced by dendritic cells contributes to the activation of T cells., [RefSeq, PubMed]; Structure and function of a family of tick-derived complement inhibitors targeting properdin. Publication Status: Online-Only, [RefSeq, PubMed]; The Role of Properdin in Killing of Non-Pathogenic Leptospira biflexa. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 4,
        "reported_c_glycosites": 16,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 15,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 16,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 4,
        "total_c_glycosites": 16,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 0,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 2,
        "glyco_site_count": 21,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15134;O15135;O15136;O75826",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0035580 specific granule lumen;GO:1904724 tertiary granule lumen",
        "go_biological_process": "GO:0006955 immune response;GO:0050821 protein stabilization;GO:0042742 defense response to bacterium;GO:0050778 positive regulation of immune response;GO:0006956 complement activation",
        "synthesized_glycan_count": 0,
        "hit_score": 12.8,
        "record_id": "P27918-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1110000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13477-1",
        "uniprot_id": [
            {
                "id": "MADCA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13477",
                "type": "external"
            }
        ],
        "mass": 40155.0,
        "length": 382,
        "protein_name": "Mucosal addressin cell adhesion molecule 1",
        "gene_name": "MADCAM1",
        "organism": "Human",
        "refseq_name": "mucosal addressin cell adhesion molecule 1 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_570116",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570116",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MADCAM1",
        "gene_names_refseq": "MACAM1; MADCAM1",
        "protein_names_uniprotkb": "Mucosal addressin cell adhesion molecule 1; MAdCAM-1; hMAdCAM-1",
        "protein_names_refseq": "MAdCAM-1; hMAdCAM-1; mucosal addressin cell adhesion molecule 1 isoform a precursor; mucosal addressin cell adhesion molecule 1",
        "tax_id": 9606,
        "disease": "food allergy (Disease Ontology:DOID:3044); Crohn's disease (Disease Ontology:DOID:8778)",
        "pathway": " (hsa:8174)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11807247;23297416;26124182;28832583;29557506;29789417;30620550;31866620;32293299;32938616;33828560;34194420;8609404;8989586;9162097;9655832",
        "class_list": "glycogene",
        "function": "Baseline levels of dynamic CD4(+) T cell adhesion to MAdCAM-1 correlate with clinical response to vedolizumab treatment in ulcerative colitis: a cohort study. Publication Status: Online-Only, [RefSeq, PubMed]; Cell adhesion leukocyte receptor expressed by mucosal venules, helps to direct lymphocyte traffic into mucosal tissues including the Peyer patches and the intestinal lamina propria. It can bind both integrin alpha-4/beta-7 and L-selectin, regulating both the passage and retention of leukocytes. Isoform 2, lacking the mucin-like domain, may be specialized in supporting integrin alpha-4/beta-7-dependent adhesion strengthening, independent of L-selectin binding., [UniProtKB]; Doxo-induced apoptosis has a role in inhibiting hepatocellular carcinoma by targeting Madcam1 and AKT and blocking protein translation initiation, [RefSeq, PubMed]; Frequency of Effector Memory Cells Expressing Integrin alpha4beta7 Is Associated With TGF-beta1 Levels in Therapy Naive HIV Infected Women With Low CD4(+) T Cell Count. Publication Status: Online-Only, [RefSeq, PubMed]; N the present study, mucosal addressin cell adhesion molecule-1 was selectively expressed on alpha-smooth muscle actin-positive reticular framework. The reticular framework may function in lymphocyte homing and segregation into the periarteriolar lymphoid sheath, lymph follicle and marginal zone., [RefSeq, PubMed]; SMAdCAM: IL-6 Ratio Influences Disease Progression and Anti-Viral Responses in SARS-CoV-2 Infection. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is an endothelial cell adhesion molecule that interacts preferentially with the leukocyte beta7 integrin LPAM-1 (alpha4beta7), L-selectin, and VLA-4 (alpha4beta1) on myeloid cells to direct leukocytes into mucosal and inflamed tissues. It is a member of the immunoglobulin family and is similar to ICAM1 and VCAM1. At least seven alternatively spliced transcripts encoding different protein isoforms have been found for this gene, but the full-length nature of some variants has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
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        "reported_phosphosites": 0,
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        "reported_snv": 579,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A5PKV4;B2RPL9;O60222;O75867;Q5UGI7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0098640 integrin binding involved in cell-matrix adhesion",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006955 immune response;GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0007229 integrin-mediated signaling pathway;GO:0007160 cell-matrix adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q13477-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000001000.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99661-1",
        "uniprot_id": [
            {
                "id": "KIF2C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99661",
                "type": "external"
            }
        ],
        "mass": 81313.0,
        "length": 725,
        "protein_name": "Kinesin-like protein KIF2C",
        "gene_name": "KIF2C",
        "organism": "Human",
        "refseq_name": "kinesin-like protein KIF2C isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001284584",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284584",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KIF2C; KNSL6",
        "gene_names_refseq": "CT139; KIF2C; KNSL6; MCAK",
        "protein_names_uniprotkb": "Kinesin-like protein KIF2C; Kinesin-like protein 6; MCAK; Mitotic centromere-associated kinesin",
        "protein_names_refseq": "kinesin-like protein 6; kinesin-like protein KIF2C isoform 2; kinesin-like protein KIF2C; mitotic centromere-associated kinesin; testis tissue sperm-binding protein Li 68n",
        "tax_id": 9606,
        "disease": "colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:11004);  (R-HSA-141430);  (R-HSA-141444);  (R-HSA-2132295);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-5663220);  (R-HSA-6811434);  (R-HSA-68877);  (R-HSA-9648025);  (R-HSA-983189)",
        "pathway_count": 11,
        "publication_count": 363,
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        "class_list": "",
        "function": "Identification as a candidate gene for the testis-specific KRPs and its specific expression in the testis was correlated with spermatogenesis and may be correlated with male infertility, [RefSeq, PubMed]; In complex with KIF18B, constitutes the major microtubule plus-end depolymerizing activity in mitotic cells (PubMed:21820309). Regulates the turnover of microtubules at the kinetochore and functions in chromosome segregation during mitosis (PubMed:19060894). Plays a role in chromosome congression and is required for the lateral to end-on conversion of the chromosome-microtubule attachment (PubMed:23891108)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; KIF2C promotes clear cell renal cell carcinoma progression via activating JAK2/STAT3 signaling pathway., [RefSeq, PubMed]; Knockdown of kinesin family member 2C restricts cell proliferation and induces cell cycle arrest in gastric cancer., [RefSeq, PubMed]; Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a kinesin-like protein that functions as a microtubule-dependent molecular motor. The encoded protein can depolymerize microtubules at the plus end, thereby promoting mitotic chromosome segregation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 35,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3ITR9;Q5JR88;Q6ICU1;Q96C18;Q96HB8;Q9BWV8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0008017 microtubule binding;GO:0016887 ATP hydrolysis activity;GO:0051010 microtubule plus-end binding;GO:0003777 microtubule motor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005819 spindle",
        "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0051315 attachment of mitotic spindle microtubules to kinetochore;GO:0051301 cell division;GO:0007018 microtubule-based movement;GO:0007080 mitotic metaphase chromosome alignment",
        "synthesized_glycan_count": 0,
        "hit_score": 36.7,
        "record_id": "Q99661-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N9Z9-1",
        "uniprot_id": [
            {
                "id": "LMTD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N9Z9",
                "type": "external"
            }
        ],
        "mass": 43408.0,
        "length": 388,
        "protein_name": "Lamin tail domain-containing protein 1",
        "gene_name": "LMNTD1",
        "organism": "Human",
        "refseq_name": "lamin tail domain-containing protein 1 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001139199",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139199",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LMNTD1; IFLTD1",
        "gene_names_refseq": "IFLTD1; LMNARS1; LMNTD1; PAS1C1",
        "protein_names_uniprotkb": "Lamin tail domain-containing protein 1; Intermediate filament tail domain-containing protein 1",
        "protein_names_refseq": "intermediate filament tail domain containing 1; intermediate filament tail domain-containing protein 1; lamin tail domain-containing protein 1 isoform 3; lamin tail domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:160492)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;38253038",
        "class_list": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DL27;B4DY70;Q8IY38",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005882 intermediate filament",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8N9Z9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q52LD8-1",
        "uniprot_id": [
            {
                "id": "RFTN2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q52LD8",
                "type": "external"
            }
        ],
        "mass": 55922.0,
        "length": 501,
        "protein_name": "Raftlin-2",
        "gene_name": "RFTN2",
        "organism": "Human",
        "refseq_name": "raftlin-2",
        "refseq_ac": [
            {
                "id": "NP_653230",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_653230",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RFTN2; C2orf11",
        "gene_names_refseq": "C2orf11; RFTN2; Raftlin-2",
        "protein_names_uniprotkb": "Raftlin-2; Raft-linking protein 2",
        "protein_names_refseq": "raft-linking protein 2; raftlin-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:130132)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;17287340;25645385;27600516;29557506;30429286;31154438;31844290;31848261;32157095;32938616;33392160;33537174;34171305;35051231;35580925;36010968;37938771",
        "class_list": "",
        "function": "Upon bacterial lipopolysaccharide stimulation, mediates clathrin-dependent internalization of TLR4 in dendritic cells, resulting in activation of TICAM1-mediated signaling and subsequent IFNB1 production. May regulate B-cell antigen receptor-mediated signaling., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14DH4;Q2TA69;Q53QE0;Q53SE1;Q96NM3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q52LD8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q494X3-1",
        "uniprot_id": [
            {
                "id": "ZN404_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q494X3",
                "type": "external"
            }
        ],
        "mass": 65425.0,
        "length": 552,
        "protein_name": "Zinc finger protein 404",
        "gene_name": "ZNF404",
        "organism": "Human",
        "refseq_name": "zinc finger protein 404",
        "refseq_ac": [
            {
                "id": "NP_001028891",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028891",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZNF404",
        "gene_names_refseq": "ZNF404",
        "protein_names_uniprotkb": "Zinc finger protein 404",
        "protein_names_refseq": "zinc finger protein 404",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:342908)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "25892735;28422318;28957321;30379171;32157095;35051231",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]; The deleterious SNPs localized in STXBP4 and ZNF404 genes were identified which might play a role in breast cancer development by dysregulating its gene expression., [RefSeq, PubMed]; We used The Cancer Genome Atlas breast cancer patient data to identify ANKLE1 and ZNF404 as the target genes of candidate TF binding site SNPs in the 19p13.11 and 19q13.31 GWAS-identified loci. These SNPs are associated with the expression of ZNF404 and ANKLE1 in breast tissue. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4FU30;K7ELF2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q494X3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95372-1",
        "uniprot_id": [
            {
                "id": "LYPA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95372",
                "type": "external"
            }
        ],
        "mass": 24737.0,
        "length": 231,
        "protein_name": "Acyl-protein thioesterase 2",
        "gene_name": "LYPLA2",
        "organism": "Human",
        "refseq_name": "acyl-protein thioesterase 2",
        "refseq_ac": [
            {
                "id": "NP_009191",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009191",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LYPLA2; APT2",
        "gene_names_refseq": "APT-2; APT2; DJ886K2.4; LYPLA2",
        "protein_names_uniprotkb": "Acyl-protein thioesterase 2; 3.1.2.-; 3.1.2.22; APT-2; LPL-II; LysoPLA II; Lysophospholipase II; Palmitoyl-protein hydrolase",
        "protein_names_refseq": "LPL-II; acyl-protein thioesterase 2; lysoPLA II; lysophospholipase II; palmitoyl-protein hydrolase; testicular tissue protein Li 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11313);  (R-HSA-373760)",
        "pathway_count": 2,
        "publication_count": 76,
        "publication_id_list": "11237011;14978216;16000162;17074750;21152083;21209280;22223895;23396970;23481700;24714562;24715725;25301951;25418920;25645385;26154972;26375851;26768311;26811146;27846572;27920218;28218747;28228285;28467828;28826475;28832583;28855257;28860189;28904123;29242379;29314611;29437277;29493099;29508533;29557506;29632711;29786170;29789417;30410026;30482805;30524438;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33707782;33912179;33936100;33968037;34019948;34087483;34171305;34211107;34357683;34405274;34509645;35051231;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37938771",
        "class_list": "",
        "function": "Acts as an acyl-protein thioesterase hydrolyzing fatty acids from S-acylated cysteine residues in proteins such as trimeric G alpha proteins, GSDMD, GAP43, ZDHHC6 or HRAS (PubMed:21152083, PubMed:28826475). Deacylates GAP43 (PubMed:21152083). Mediates depalmitoylation of ZDHHC6 (PubMed:28826475). Has lysophospholipase activity (PubMed:25301951). Hydrolyzes prostaglandin glycerol esters (PG-Gs) in the following order prostaglandin D2-glycerol ester (PGD2-G) > prostaglandin E2 glycerol ester (PGE2-G) > prostaglandin F2-alpha-glycerol ester (PGF2-alpha-G) (PubMed:25301951). Hydrolyzes 1-arachidonoylglycerol but not 2-arachidonoylglycerol or arachidonoylethanolamide (PubMed:25301951)., [UniProtKB, PubMed, PubMed, PubMed]; Dynamic palmitoylation links cytosol-membrane shuttling of acyl-protein thioesterase-1 and acyl-protein thioesterase-2 with that of proto-oncogene H-ras product and growth-associated protein-43, [RefSeq, PubMed]; LYPLA1 and LYPLA2 are each able to account for the loss of the other to maintain lipid homeostasis in cells Erratum:[J Lipid Res. 2019 Jul;60(7):1345. doi: 10.1194/jlr.ERR119000139. PMID: 31262966], [RefSeq, PubMed]; Lysophospholipases are enzymes that act on biological membranes to regulate the multifunctional lysophospholipids. There are alternatively spliced transcript variants described for this gene but the full length nature is not known yet. [provided by RefSeq, Jul 2008]., [RefSeq]; Palmitoylated acyl protein thioesterase APT2 deforms membranes to extract substrate acyl chains., [RefSeq, PubMed]; Results demonstrate that APT-2 is the protein thioesterase involved in the acylation/deacylation cycle operating in GAP-43 subcellular distribution. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z4Z2",
        "ec_number_list": [
            {
                "id": "3.1.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.1",
                "type": "external"
            },
            {
                "id": "3.1.1.56",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.56",
                "type": "external"
            },
            {
                "id": "3.1.1.84",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.84",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.2.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.1.1.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.13",
                "type": "external"
            },
            {
                "id": "3.1.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.6",
                "type": "external"
            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.5.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.1",
                "type": "external"
            },
            {
                "id": "3.1.1.47",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.47",
                "type": "external"
            },
            {
                "id": "3.1.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.23",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "3.1.1.93",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.93",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0045296 cadherin binding;GO:0004622 phosphatidylcholine lysophospholipase activity;GO:0008474 palmitoyl-(protein) hydrolase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0005795 Golgi stack",
        "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0046464 acylglycerol catabolic process;GO:1905344 prostaglandin catabolic process;GO:0007411 axon guidance",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "O95372-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BWF2-1",
        "uniprot_id": [
            {
                "id": "TRAIP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BWF2",
                "type": "external"
            }
        ],
        "mass": 53294.0,
        "length": 469,
        "protein_name": "E3 ubiquitin-protein ligase TRAIP",
        "gene_name": "TRAIP",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase TRAIP",
        "refseq_ac": [
            {
                "id": "NP_005870",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005870",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TRAIP; RNF206; TRIP",
        "gene_names_refseq": "RNF206; SCKL9; TRAIP; TRIP",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase TRAIP; 2.3.2.27; RING finger protein 206; TRAF-interacting protein",
        "protein_names_refseq": "E3 ubiquitin-protein ligase TRAIP; RING-type E3 ubiquitin transferase TRAIP; ring finger protein 206",
        "tax_id": 9606,
        "disease": "Seckel syndrome 9 (Disease Ontology:DOID:0070005)",
        "pathway": " (hsa:10293);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 78,
        "publication_id_list": "11062501;11237011;11350924;12646216;14676304;14734113;15224091;15224092;15571818;16595681;16849449;16954532;17287340;17544371;18662542;19028597;19054851;19352404;19452197;19489725;19851334;19874575;19940261;2261476;22945920;23481700;24553286;24715725;25335891;25576301;26154972;26595769;26711499;26781088;26820530;26992070;27462463;28228285;28832583;28834231;28904123;29242379;29393594;29557506;30165463;30379171;30524438;30779550;31545170;31844290;31937595;32157095;32387766;32502341;32897882;32938616;33141586;33298915;33392160;33912179;33936100;33968037;33981976;34087483;34211107;34349117;34509645;34932366;35580925;36010968;36064576;36594163;37340703;37604812;38100027;9104814;9380723;9668046",
        "class_list": "",
        "function": "CYLD interacts with TRIP and regulates negatively nuclear factor kappaB activation by tumor necrosis factor., [RefSeq, PubMed]; E3 ubiquitin ligase required to protect genome stability in response to replication stress (PubMed:25335891, PubMed:26595769, PubMed:26711499, PubMed:26781088, PubMed:27462463, PubMed:31545170). Acts as a key regulator of interstrand cross-link repair, which takes place when both strands of duplex DNA are covalently tethered together, thereby blocking replication and transcription (By similarity). Controls the choice between the two pathways of replication-coupled interstrand-cross-link repair by mediating ubiquitination of MCM7 subunit of the CMG helicase complex (By similarity). Short ubiquitin chains on MCM7 promote recruitment of DNA glycosylase NEIL3 (By similarity). If the interstrand cross-link cannot be cleaved by NEIL3, the ubiquitin chains continue to grow on MCM7, promoting the unloading of the CMG helicase complex by the VCP/p97 ATPase, enabling the Fanconi anemia DNA repair pathway (By similarity). Only catalyzes ubiquitination of MCM7 when forks converge (By similarity). Also involved in the repair of covalent DNA-protein cross-links (DPCs) during DNA synthesis: promotes ubiquitination of DPCs, leading to their degradation by the proteasome (By similarity). Has also been proposed to play a role in promoting translesion synthesis by mediating the assembly of 'Lys-63'-linked poly-ubiquitin chains on the Y-family polymerase POLN in order to facilitate bypass of DNA lesions and preserve genomic integrity (PubMed:24553286). The function in translesion synthesis is however controversial (PubMed:26595769). Acts as a regulator of the spindle assembly checkpoint (PubMed:25335891). Also acts as a negative regulator of innate immune signaling by inhibiting activation of NF-kappa-B mediated by TNF (PubMed:22945920). Negatively regulates TLR3/4- and RIG-I-mediated IRF3 activation and subsequent IFNB1 production and cellular antiviral response by promoting 'Lys-48'-linked polyubiquitination of TNK1 leading to its proteasomal degradation (PubMed:22945920)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Silencing TRAIP suppresses cell proliferation and migration/invasion of triple negative breast cancer via RB-E2F signaling and EMT., [RefSeq, PubMed]; TRAIP modulates the IGFBP3/AKT pathway to enhance the invasion and proliferation of osteosarcoma by promoting KANK1 degradation. Publication Status: Online-Only, [RefSeq, PubMed]; TRAIP resolves DNA replication-transcription conflicts during the S-phase of unperturbed cells. Publication Status: Online-Only, [RefSeq, PubMed]; TRAIP suppressed apoptosis and cell cycle to promote prostate cancer proliferation via TRAF2-PI3K-AKT pathway activation., [RefSeq, PubMed]; This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]., [RefSeq]; ZNF212 promotes genomic integrity through direct interaction with TRAIP., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 1,
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
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            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
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            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
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            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
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            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
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            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
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            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
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            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
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            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
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            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
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            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
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        ],
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        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0007165 signal transduction;GO:0006915 apoptotic process;GO:0006974 DNA damage response;GO:0016567 protein ubiquitination;GO:0010804 negative regulation of tumor necrosis factor-mediated signaling pathway",
        "synthesized_glycan_count": 0,
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    {
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                "id": "LYPD5_HUMAN",
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        "mass": 26936.0,
        "length": 251,
        "protein_name": "Ly6/PLAUR domain-containing protein 5",
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        "refseq_ac": [
            {
                "id": "NP_001026919",
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        "gene_names_uniprotkb": "LYPD5; PRO4356",
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        "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 5",
        "protein_names_refseq": "human antigen with LU-domains expressed in skin; ly6/PLAUR domain-containing protein 5 isoform A precursor; ly6/PLAUR domain-containing protein 5; metastasis-associated protein",
        "tax_id": 9606,
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        "pathway": " (hsa:284348);  (R-HSA-163125)",
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        "publication_id_list": "11072085;11237011;12975309;15340161;19913121;20628086;23896969;2443973;24715725;25414274;29557506;33141586;3422494;35051231",
        "class_list": "",
        "function": "Expression of the Ly6/uPAR-domain proteins C4.4A and Haldisin in non-invasive and invasive skin lesions, [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The study identifies LYPD5 a novel differentiation marker of stratum granulosum in squamous epithelia., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
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        "secondary_ac_list": "Q6PEX9;Q96DR2",
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        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0098552 side of membrane",
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    {
        "uniprot_canonical_ac": "Q9NXJ0-1",
        "uniprot_id": [
            {
                "id": "M4A12_HUMAN",
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        ],
        "mass": 28069.0,
        "length": 267,
        "protein_name": "Membrane-spanning 4-domains subfamily A member 12",
        "gene_name": "MS4A12",
        "organism": "Human",
        "refseq_name": "membrane-spanning 4-domains subfamily A member 12 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001157942",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157942",
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        ],
        "gene_names_uniprotkb": "MS4A12",
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        "protein_names_uniprotkb": "Membrane-spanning 4-domains subfamily A member 12",
        "protein_names_refseq": "membrane-spanning 4-domains subfamily A member 12 isoform 2; membrane-spanning 4-domains subfamily A member 12",
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        "pathway": " (hsa:54860)",
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        "class_list": "",
        "function": "CLCA4 and MS4A12 as the significant gene biomarkers of primary colorectal cancer., [RefSeq, PubMed]; In early stage colon cancer, the patients with low MS4A12 expression had a poor survival, while in advanced stage colon cancer MS412 had little prognostic value., [RefSeq, PubMed]; MS4A12 is a colon-selective store-operated calcium channel promoting malignant cell processes. Erratum:[Cancer Res. 2008 Jun 15;68(12):4958], [RefSeq, PubMed]; May be involved in signal transduction as a component of a multimeric receptor complex., [UniProtKB]; RNA interference of CDX1 and CDX2 and chromatin immunoprecipitation in colon cancer cells revealed that MS4A12 transcript and protein expression is essentially dependent on the presence of endogenous CDX2. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a cell surface protein found primarily in the apical membrane of colonocytes. Silencing of this gene in colon cancer cells inhibits the proliferation, cell motility, and chemotactic invasion of cells. This gene is part of a cluster of similar genes found on chromosome 11. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Aug 2009]., [RefSeq]",
        "predicted_glycosites": 1,
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        "secondary_ac_list": "F5GX98;Q8N6L4",
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        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway",
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        "hit_score": 1.1,
        "record_id": "Q9NXJ0-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5VYS4-1",
        "uniprot_id": [
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                "id": "MEDAG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5VYS4",
                "type": "external"
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        ],
        "mass": 34190.0,
        "length": 303,
        "protein_name": "Mesenteric estrogen-dependent adipogenesis protein",
        "gene_name": "MEDAG",
        "organism": "Human",
        "refseq_name": "",
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        "gene_names_uniprotkb": "MEDAG; AWMS3; C13orf33; MEDA4",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Mesenteric estrogen-dependent adipogenesis protein; Activated in W/Wv mouse stomach 3 homolog; MEDA-4; Mesenteric estrogen-dependent adipose 4; hAWMS3",
        "protein_names_refseq": "",
        "tax_id": 9606,
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        "pathway": " (hsa:84935)",
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        "publication_count": 12,
        "publication_id_list": "11237011;18452278;22510272;27862975;29331515;29557506;29786170;30429286;31844290;31848261;35051231;35580925",
        "class_list": "",
        "function": "Involved in processes that promote adipocyte differentiation, lipid accumulation, and glucose uptake in mature adipocytes., [UniProtKB]",
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        "secondary_ac_list": "Q8IXF1;Q96K26;Q96NC8",
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        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0045600 positive regulation of fat cell differentiation",
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    {
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        ],
        "mass": 16372.0,
        "length": 150,
        "protein_name": "Putative solute carrier family 71 member 3",
        "gene_name": "SLC71A3P",
        "organism": "Human",
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        "refseq_ac": [],
        "gene_names_uniprotkb": "SLC71A3P; HIATL2; MFSD14CP; MFSD14C",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative solute carrier family 71 member 3; Hippocampus abundant transcript-like protein 2; Major facilitator superfamily domain-containing protein 14C; Solute carrier family 71 member 3, pseudogene",
        "protein_names_refseq": "",
        "tax_id": 9606,
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        "pathway_count": 0,
        "publication_count": 11,
        "publication_id_list": "29557506;32897882;32983136;33691108;33968037;34509645;35051231;35154160;35251023;36010968;36241641",
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        "secondary_ac_list": "Q9BSG7;R4GN14",
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        "go_molecular_function": "GO:0022857 transmembrane transporter activity",
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    {
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                "type": "external"
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        ],
        "mass": 107559.0,
        "length": 952,
        "protein_name": "Meiosis-specific coiled-coil domain-containing protein MEIOC",
        "gene_name": "MEIOC",
        "organism": "Human",
        "refseq_name": "meiosis-specific coiled-coil domain-containing protein MEIOC",
        "refseq_ac": [
            {
                "id": "NP_001138552",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138552",
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        ],
        "gene_names_uniprotkb": "MEIOC; C17orf104",
        "gene_names_refseq": "C17orf104; MEIOC",
        "protein_names_uniprotkb": "Meiosis-specific coiled-coil domain-containing protein MEIOC; Meiosis-specific with coiled-coil domain protein",
        "protein_names_refseq": "meiosis-specific coiled-coil domain-containing protein MEIOC; meiosis-specific with coiled-coil domain protein",
        "tax_id": 9606,
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        "pathway": " (hsa:284071)",
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        "publication_count": 13,
        "publication_id_list": "23481700;25576301;26742488;26992070;28380054;29242379;29557506;29769354;32387766;33592498;33981976;35580925;39534244",
        "class_list": "",
        "function": "Is required for meiosis completion in both male and female germ cells. Confers stability to numerous meiotic mRNAs in gonads allowing proper initiation and progression into meiosis prophase I. The function may involve YTHDC2 and is independent of induction by retinoic acid (RA). Maintains an extended meiotic prophase I by properly promoting the transition from a mitotic to a meiotic cell cycle program by binding transcripts through its interaction with YTHDC2 that regulate the mitotic cell cycle., [UniProtKB, UniProtKB]; Meioc is expressed in germ cells during meiotic prophase I. MEIOC prevents meiotic transcript degradation and interacts with an RNA helicase that binds numerous meiotic mRNAs. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "B4DXJ2;B5MD93;B9EGQ6;C4AM97;Q4G0Y1;Q8IVZ7;Q8NA45",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0051310 metaphase chromosome alignment;GO:0007144 female meiosis I;GO:0048255 mRNA stabilization;GO:0007286 spermatid development;GO:0006302 double-strand break repair",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "A2RUB1-4",
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        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
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                "type": "external"
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        ],
        "mass": 41109.0,
        "length": 364,
        "protein_name": "Lysophosphatidic acid receptor 1",
        "gene_name": "LPAR1",
        "organism": "Human",
        "refseq_name": "lysophosphatidic acid receptor 1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001392",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001392",
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        ],
        "gene_names_uniprotkb": "LPAR1; EDG2; LPA1",
        "gene_names_refseq": "EDG2; Gpcr26; LPA1; LPAR1; Mrec1.3; VZG1; edg-2; rec.1.3; vzg-1",
        "protein_names_uniprotkb": "Lysophosphatidic acid receptor 1; LPA receptor 1; LPA-1; Lysophosphatidic acid receptor Edg-2",
        "protein_names_refseq": "LPA receptor 1; LPA-1; endothelial differentiation, lysophosphatidic acid G-protein-coupled receptor, 2; lysophosphatidic acid receptor 1 isoform a; lysophosphatidic acid receptor Edg-2; ventricular zone gene 1",
        "tax_id": 9606,
        "disease": "developmental and epileptic encephalopathy 72 (Disease Ontology:DOID:0112208); transient cerebral ischemia (Disease Ontology:DOID:224); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:1902);  (R-HSA-416476);  (R-HSA-418594);  (R-HSA-419408)",
        "pathway_count": 4,
        "publication_count": 79,
        "publication_id_list": "10.1101/2023.09.13.557529;10191087;10488065;10488122;10567430;10617617;10727522;10727532;10753843;10799507;10861009;11007482;11015615;11093753;11237011;11742120;11753430;12120503;12427546;12730698;15951850;16182515;16268778;16339447;16634148;16754659;16923326;18066075;18434541;18501205;18515384;18577758;18936096;1905813;19306925;19366702;19656035;19733258;20061941;2160972;23388400;24275569;24900670;25025571;2534964;25645385;25732591;25892735;26091040;26990079;2748346;2834384;2841328;29393594;29735753;29769354;3086311;31154438;31204173;32350084;32983136;34932366;35580925;37749552;37938771;38712822;39009409;7937899;8015379;8406495;8626678;8664309;8878560;9069262;9070858;9305846;9525886;9770463;9804623",
        "class_list": "",
        "function": "CYRI-B-mediated macropinocytosis drives metastasis via lysophosphatidic acid receptor uptake. Publication Status: Online-Only, [RefSeq, PubMed]; LPA1-mediated inhibition of CXCR4 attenuates CXCL12-induced signaling and cell migration. Publication Status: Online-Only, [RefSeq, PubMed]; Lysophosphatidic acid receptor 1 inhibition: a potential treatment target for pulmonary fibrosis. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for lysophosphatidic acid (LPA) (PubMed:19306925, PubMed:25025571, PubMed:26091040, PubMed:9070858). Plays a role in the reorganization of the actin cytoskeleton, cell migration, differentiation and proliferation, and thereby contributes to the responses to tissue damage and infectious agents. Activates downstream signaling cascades via the G(i)/G(o), G(12)/G(13), and G(q) families of heteromeric G proteins. Signaling inhibits adenylyl cyclase activity and decreases cellular cAMP levels (PubMed:26091040). Signaling triggers an increase of cytoplasmic Ca(2+) levels (PubMed:19656035, PubMed:19733258, PubMed:26091040). Activates RALA; this leads to the activation of phospholipase C (PLC) and the formation of inositol 1,4,5-trisphosphate (PubMed:19306925). Signaling mediates activation of down-stream MAP kinases (By similarity). Contributes to the regulation of cell shape. Promotes Rho-dependent reorganization of the actin cytoskeleton in neuronal cells and neurite retraction (PubMed:26091040). Promotes the activation of Rho and the formation of actin stress fibers (PubMed:26091040). Promotes formation of lamellipodia at the leading edge of migrating cells via activation of RAC1 (By similarity). Through its function as LPA receptor, plays a role in chemotaxis and cell migration, including responses to injury and wounding (PubMed:18066075, PubMed:19656035, PubMed:19733258). Plays a role in triggering inflammation in response to bacterial lipopolysaccharide (LPS) via its interaction with CD14. Promotes cell proliferation in response to LPA (By similarity). Inhibits the intracellular ciliogenesis pathway in response to LPA and through AKT1 activation (PubMed:31204173). Required for normal skeleton development. May play a role in osteoblast differentiation. Required for normal brain development. Required for normal proliferation, survival and maturation of newly formed neurons in the adult dentate gyrus. Plays a role in pain perception and in the initiation of neuropathic pain (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The integral membrane protein encoded by this gene is a lysophosphatidic acid (LPA) receptor from a group known as EDG receptors. These receptors are members of the G protein-coupled receptor superfamily. Utilized by LPA for cell signaling, EDG receptors mediate diverse biologic functions, including proliferation, platelet aggregation, smooth muscle contraction, inhibition of neuroblastoma cell differentiation, chemotaxis, and tumor cell invasion. Many transcript variants encoding a few different isoforms have been identified for this gene. [provided by RefSeq, Oct 2020]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DK36;O00656;O00722;P78351",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0001965 G-protein alpha-subunit binding;GO:0030165 PDZ domain binding;GO:0070915 lysophosphatidic acid receptor activity;GO:0035727 lysophosphatidic acid binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane",
        "go_biological_process": "GO:1902018 negative regulation of cilium assembly;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "Q92633-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5T0T0-1",
        "uniprot_id": [
            {
                "id": "MARH8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5T0T0",
                "type": "external"
            }
        ],
        "mass": 32965.0,
        "length": 291,
        "protein_name": "E3 ubiquitin-protein ligase MARCHF8",
        "gene_name": "MARCHF8",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase MARCHF8 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001002266",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002266",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MARCHF8; MARCH8; MIR; RNF178",
        "gene_names_refseq": "CMIR; MARCH-VIII; MARCH8; MARCHF8; MIR; RNF178; c-MIR",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF8; 2.3.2.27; Cellular modulator of immune recognition; MARCH-VIII; Membrane-associated RING finger protein 8; Membrane-associated RING-CH protein VIII; RING finger protein 178; RING-type E3 ubiquitin transferase MARCHF8; c-MIR",
        "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH8; E3 ubiquitin-protein ligase MARCHF8 isoform a; E3 ubiquitin-protein ligase MARCHF8; RING finger protein 178; RING-type E3 ubiquitin transferase MARCH8; RING-type E3 ubiquitin transferase MARCHF8; c-mir, cellular modulator of immune recognition; cellular modulator of immune recognition (c-MIR); membrane associated ring finger 8; membrane-associated RING finger protein 8; membrane-associated RING-CH protein VIII; membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:220972)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "11237011;12582153;14722266;16385451;18389477;19117940;19566897;23186163;28320822;28832583;28904123;29242379;30759391;31217245;31844290;32157095;32934085;33912179;33968037;34183449;34285233;34433824;35019698;35051231;35503863;35580925;37747937;37772822;38226814;38299743;38944094;39311660",
        "class_list": "",
        "function": "(Microbial infection) Mediates 'Lys-63'-linked polyubiquitination of hepatitis C virus/HCV protein NS2 which allows its binding to HGS, an ESCRT-0 complex component, and this interaction is essential for HCV envelopment., [UniProtKB, PubMed]; C-MIR induced specific down-regulation of B7-2 surface expression through ubiquitination, rapid endocytosis, and lysosomal degradation, [RefSeq, PubMed]; E3 Ubiquitin Ligase MARCH8 Promotes Pancreatic Cancer Growth and Metastasis by Activating STAT3 via Degradation of PTPN4., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that plays several important roles in innate immunity and adaptive immunity (PubMed:34285233, PubMed:35019698, PubMed:35503863). Mediates ubiquitination of CD86 and MHC class II proteins, such as HLA-DR alpha and beta, and promotes their subsequent endocytosis and sorting to lysosomes via multivesicular bodies (PubMed:19117940, PubMed:19566897). Possesses a very broad antiviral activity by specifically inactivating different viral fusion proteins (PubMed:32934085). Targets and ubiquitinates cytoplasmic lysine residues of viral envelope glycoproteins with single transmembrane domains leading to their lysosomal degradation (PubMed:35019698). Therefore, shows broad-spectrum inhibition against many viruses including retroviruses, rhabdoviruses, arenaviruses, sarbecoviruses or influenzaviruses (PubMed:34285233, PubMed:35019698). Strongly blocks human immunodeficiency virus type 1 envelope glycoprotein incorporation into virions by down-regulating its cell surface expression. Also blocks ebola virus glycoprotein/GP incorporation via surface down-regulation (PubMed:32934085). Mediates 'Lys-63'-linked polyubiquitination of influenza M2 to target it to lysosome for degradation (PubMed:34285233). Mediates the regulation of constitutive ubiquitination and trafficking of the viral restriction factor BST2 within the endocytic pathway (PubMed:28320822). Plays a role in maintenance of immune tolerance to self by promoting the turnover and proteasomal degradation of PD-L1/CD274 via ubiquitination (PubMed:34183449). Catalyzes the 'Lys-63'-linked polyubiquitylation of cGAS thereby inhibiting its DNA binding ability and impairing its antiviral innate immunity (PubMed:35503863). Negatively regulates IL7-mediated T-cell homeostasis by mediating 'Lys-27'-linked polyubiquitination of IL7R, leading to its lysosomal degradation (PubMed:39311660)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; EGR1 functions as a new host restriction factor for SARS-CoV-2 to inhibit virus replication through the E3 ubiquitin ligase MARCH8., [RefSeq, PubMed]; Human MARCH1, 2, and 8 block Ebola virus envelope glycoprotein cleavage via targeting furin P domain., [RefSeq, PubMed]; MARCH8 inhibits pseudorabies virus replication by trapping the viral cell-to-cell fusion complex in the trans-Golgi network., [RefSeq, PubMed]; MARCH8 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH8 induces the internalization of several membrane glycoproteins (Goto et al., 2003 [PubMed 12582153]; Bartee et al., 2004 [PubMed 14722266]).[supplied by OMIM, Apr 2010]., [RefSeq]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The membrane-associated ubiquitin ligase MARCHF8 stabilizes the human papillomavirus oncoprotein E7 by degrading CUL1 and UBE2L3 in head and neck cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8E7;H0Y7C6;Q5T0S8;Q8TC72",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity;GO:0042287 MHC protein binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005764 lysosome;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0006955 immune response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0002250 adaptive immune response;GO:0000209 protein polyubiquitination;GO:0002495 antigen processing and presentation of peptide antigen via MHC class II",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q5T0T0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P83111-1",
        "uniprot_id": [
            {
                "id": "LACTB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P83111",
                "type": "external"
            }
        ],
        "mass": 60694.0,
        "length": 547,
        "protein_name": "Serine beta-lactamase-like protein LACTB, mitochondrial",
        "gene_name": "LACTB",
        "organism": "Human",
        "refseq_name": "serine beta-lactamase-like protein LACTB, mitochondrial isoform c precursor",
        "refseq_ac": [
            {
                "id": "NP_001275514",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001275514",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LACTB; MRPL56; PRO1781",
        "gene_names_refseq": "G24; LACTB; MRPL56",
        "protein_names_uniprotkb": "Serine beta-lactamase-like protein LACTB, mitochondrial; 3.4.-.-",
        "protein_names_refseq": "mitochondrial 39S ribosomal protein L56; serine beta-lactamase-like protein LACTB, mitochondrial isoform c precursor; serine beta-lactamase-like protein LACTB, mitochondrial; serine beta-lactamase-like protein, mitochondrial",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:114294)",
        "pathway_count": 1,
        "publication_count": 70,
        "publication_id_list": "11237011;11551941;11707067;12164938;12975309;17081983;19608861;19858488;20068231;25576301;25892735;26154972;26992070;27397612;27452731;27600516;27846572;27920218;28063628;28218747;28228285;28329758;28510447;28832583;28834231;28904123;29242379;29393594;29437277;29557506;29632046;29769354;30315122;30410026;30429286;30620550;30833945;31154438;31530632;31844290;31998317;32157095;32161166;32350084;32357974;32387766;32938616;32983136;33141586;33298915;33392160;33592498;33717175;33912179;33936100;34185709;34357683;34561969;34932366;35051231;35251023;35494241;35580925;36010968;36375842;36534696;37157950;38176415;39047638;40596516",
        "class_list": "",
        "function": "Differential expression of a novel gene, G24, in response to hsp27 and cell differentiation in human keratinocytes.(G24 PROTEIN), [RefSeq, PubMed]; LACTB exerts tumor suppressor properties in epithelial ovarian cancer through regulation of Slug. Erratum:[Life Sci Alliance. 2023 Dec 6;7(2):e202302497. doi: 10.26508/lsa.202302497. PMID: 38056910] Publication Status: Online-Only, [RefSeq, PubMed]; LACTB suppresses liver cancer progression through regulation of ferroptosis., [RefSeq, PubMed]; Mitochondrial serine protease that acts as a regulator of mitochondrial lipid metabolism (PubMed:28329758). Acts by decreasing protein levels of PISD, a mitochondrial enzyme that converts phosphatidylserine (PtdSer) to phosphatidylethanolamine (PtdEtn), thereby affecting mitochondrial lipid metabolism (PubMed:28329758). It is unclear whether it acts directly by mediating proteolysis of PISD or by mediating proteolysis of another lipid metabolism protein (PubMed:28329758). Acts as a tumor suppressor that has the ability to inhibit proliferation of multiple types of breast cancer cells: probably by promoting decreased levels of PISD, thereby affecting mitochondrial lipid metabolism (PubMed:28329758)., [UniProtKB, PubMed]; OXCT1 functions as a succinyltransferase, contributing to hepatocellular carcinoma via succinylating LACTB., [RefSeq, PubMed]; PCBP1 protects bladder cancer cells from mitochondria injury and ferroptosis by inducing LACTB mRNA degradation., [RefSeq, PubMed]; The structure of the human LACTB filament reveals the mechanisms of assembly and membrane binding. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a mitochondrially-localized protein that has sequence similarity to prokaryotic beta-lactamases. Many of the residues responsible for beta-lactamase activity are not conserved in this protein, suggesting it may have a different enzymatic function. Increased expression of the related mouse gene was found to be associated with obesity. Alternative splicing results in multiple transcript variants encoding different protein isoforms. [provided by RefSeq, Dec 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P83096",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0008233 peptidase activity",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006508 proteolysis;GO:0006629 lipid metabolic process;GO:0019216 regulation of lipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "P83111-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14728-1",
        "uniprot_id": [
            {
                "id": "S75A1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14728",
                "type": "external"
            }
        ],
        "mass": 48339.0,
        "length": 455,
        "protein_name": "Solute carrier family 75 member 1",
        "gene_name": "SLC75A1",
        "organism": "Human",
        "refseq_name": "solute carrier family 75 member 1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001111",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001111",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC75A1; MFSD10; TETRAN",
        "gene_names_refseq": "MFSD10; SLC75A1; TETRAN; TETTRAN",
        "protein_names_uniprotkb": "Solute carrier family 75 member 1; Major facilitator superfamily domain-containing protein 10; Tetracycline transporter-like protein",
        "protein_names_refseq": "major facilitator superfamily domain containing 10; major facilitator superfamily domain-containing protein 10; solute carrier family 75 member 1 isoform a; tetracycline transporter-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10227)",
        "pathway_count": 1,
        "publication_count": 56,
        "publication_id_list": "11237011;17362938;18638446;20112406;22869377;23481700;24715725;25418920;25469497;25576301;25645385;26154972;26375851;26811146;26929215;26992070;27600516;27846572;28063628;28218747;28228285;28514659;28832583;28855257;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29789417;30315122;30429286;31844290;32157095;32265295;32387766;32488085;32502341;32938616;32983136;33298915;33592498;33912179;33968037;34171305;34509645;34932366;35051231;35580925;36284347;37938771;8353488",
        "class_list": "",
        "function": "A BLAST search identified the possible human orthologue of Tpo1p, tetracycline transporter-like protein (TETRAN), whose overexpression in cultured human cells caused resistance to some NSAIDs, suggesting that TETRAN is an efflux pump for some NSAIDs., [RefSeq, PubMed]; Probable organic anion transporter which may serve as a transporter for some non-steroidal anti-inflammatory drugs (NSAIDs) as well as other organic anions across the luminal membranes of renal proximal tubules at the final excretion step into the urine., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; TETRAN is a novel human organic anion transporter, and that it serves as a transporter for some NSAIDs and various other organic anions at the final excretion step., [RefSeq, PubMed]; This gene encodes a member of the major facilitator superfamily of transporter proteins. The encoded protein likely functions in efflux of organic anions, including the non-steroidal anti-inflammatory drugs indomethacin and diclofenac. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q07706",
        "ec_number_list": [],
        "go_molecular_function": "GO:0022857 transmembrane transporter activity;GO:0008493 tetracycline transmembrane transporter activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0031526 brush border membrane;GO:0005637 nuclear inner membrane;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006915 apoptotic process;GO:0043252 sodium-independent organic anion transport",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q14728-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HDD0-1",
        "uniprot_id": [
            {
                "id": "PLAT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HDD0",
                "type": "external"
            }
        ],
        "mass": 18750.0,
        "length": 168,
        "protein_name": "Phospholipase A and acyltransferase 1",
        "gene_name": "PLAAT1",
        "organism": "Human",
        "refseq_name": "phospholipase A and acyltransferase 1",
        "refseq_ac": [
            {
                "id": "NP_001353041",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001353041",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLAAT1; HRASLS",
        "gene_names_refseq": "A-C1; H-REV107; HRASLS1; HRASLS; HRSL1; HSD28; PLA/AT1; PLAAT-1; PLAAT1",
        "protein_names_uniprotkb": "Phospholipase A and acyltransferase 1; 2.3.1.-; 3.1.1.32; 3.1.1.4; HRAS-like suppressor 1; HRSL1; Phospholipid-metabolizing enzyme A-C1",
        "protein_names_refseq": "H-REV107 protein-related protein; HRAS like suppressor; HRAS-like suppressor 1; phospholipase A and acyltransferase 1; phospholipase A/acyltransferase 1; phospholipid-metabolizing enzyme A-C1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57110);  (R-HSA-1482839)",
        "pathway_count": 2,
        "publication_count": 42,
        "publication_id_list": "10092647;10336645;10455175;10681567;11031251;11112443;11237011;11830583;12161451;12359733;12522102;15695510;15863501;15944408;16617059;16818490;18195019;18287005;18458083;18614531;18772128;18781350;19019078;19351971;19501189;20705608;20837014;21880860;22605381;22825852;26503625;27623847;28743497;2925608;2925633;34087483;35580925;36703911;7060561;8300559;9188469;9417066",
        "class_list": "",
        "function": "A novel molecular mechanism describing K-Ras and H-REV107 binding is suggested and insights into new K-Ras effector target drugs are provided., [RefSeq, PubMed]; A possible enzyme activity of A-C1, [RefSeq, PubMed]; Effects of Lipid Metabolism-Related Genes PTGIS and HRASLS on Phenotype, Prognosis, and Tumor Immunity in Lung Squamous Cell Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:21880860, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:21880860, PubMed:22825852, PubMed:27623847). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:21880860). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE) which serves as precursor for N-acylethanolamines (NAEs) (PubMed:21880860, PubMed:22825852, PubMed:27623847)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The HRASLS (PLA/AT) subfamily of enzymes. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The phospholipase active site possesses a structurally conserved Cys-His-His triad as found in NlpC/P60 peptidases, indicating H-REV107 should adopt a similar catalytic mechanism towards phospholipid substrates to that of NlpC/P60 peptidases., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D2KX19;Q6X7C0;Q86WS9;X6R3D1",
        "ec_number_list": [
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.32",
                "type": "external"
            },
            {
                "id": "3.1.1.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.34",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.1.111",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.111",
                "type": "external"
            },
            {
                "id": "3.1.1.118",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.118",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004623 phospholipase A2 activity;GO:0008970 phospholipase A1 activity;GO:0016410 N-acyltransferase activity;GO:0008374 O-acyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005641 nuclear envelope lumen;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:1903008 organelle disassembly;GO:0016042 lipid catabolic process;GO:0046470 phosphatidylcholine metabolic process;GO:0070306 lens fiber cell differentiation;GO:0070292 N-acylphosphatidylethanolamine metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q9HDD0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14242-1",
        "uniprot_id": [
            {
                "id": "SELPL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14242",
                "type": "external"
            }
        ],
        "mass": 43201.0,
        "length": 412,
        "protein_name": "P-selectin glycoprotein ligand 1",
        "gene_name": "SELPLG",
        "organism": "Human",
        "refseq_name": "P-selectin glycoprotein ligand 1 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001193538",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001193538",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SELPLG",
        "gene_names_refseq": "CD162; CLA; PSGL-1; PSGL1; SELPLG",
        "protein_names_uniprotkb": "P-selectin glycoprotein ligand 1; PSGL-1; Selectin P ligand",
        "protein_names_refseq": "P-selectin glycoprotein ligand 1 isoform 1 precursor; P-selectin glycoprotein ligand 1; cutaneous lymphocyte-associated associated antigen",
        "tax_id": 9606,
        "disease": "carotid artery disease (Disease Ontology:DOID:3407)",
        "pathway": " (hsa:6404);  (R-HSA-202733)",
        "pathway_count": 2,
        "publication_count": 111,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10606205;10713099;10764623;10978329;11081633;11207550;11237011;11256994;11564780;11566773;11779189;11812992;12070135;12208882;12387735;12403782;12469115;12736247;12782713;14529530;14615387;15000751;15528364;15681301;15721307;1591491;16258728;16297198;16585556;16691243;16737840;16783819;17064312;17099249;17116209;17132726;17167768;17172599;17322099;17379836;17442946;17452516;17505016;17525755;17563375;17580308;17600130;17615384;17625065;17868453;18045383;18196517;19279206;19543284;21193412;21659548;21850230;23186163;23584533;23945545;24043627;24703780;24764293;25102098;2538457;25502872;25813380;26768311;28228285;28649982;29242379;29557506;30315122;31092671;31844290;32350084;32357974;32387766;32983136;33968037;34433824;34509645;35051231;35251023;35580925;37819238;37854605;38243063;39148126;468991;7505206;7509040;7521878;7541799;7559387;7585949;7585950;8163559;8166770;8314844;8702529;9052782;9169774;9242610;9295288;9382878;9507018;9693095;9763524",
        "class_list": "glycogene",
        "function": "(Microbial infection) Acts as a receptor for enterovirus 71., [UniProtKB, PubMed]; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E-, P- and L-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture., [UniProtKB, PubMed, PubMed]; Correlations of PSGL-1 VNTR polymorphism with the susceptibility to severe HFMD associated with EV-71 and the immune status after infection. Publication Status: Online-Only, [RefSeq, PubMed]; PSGL-1 Blockade Induces Classical Activation of Human Tumor-associated Macrophages., [RefSeq, PubMed]; PSGL-1 decorated with sialyl Lewis[a/x] promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement. Publication Status: Online-Only, [RefSeq, PubMed]; PSGL-1: a novel immune checkpoint driving T-cell dysfunction in obstructive sleep apnea. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a glycoprotein that functions as a high affinity counter-receptor for the cell adhesion molecules P-, E- and L- selectin expressed on myeloid cells and stimulated T lymphocytes. As such, this protein plays a critical role in leukocyte trafficking during inflammation by tethering of leukocytes to activated platelets or endothelia expressing selectins. This protein requires two post-translational modifications, tyrosine sulfation and the addition of the sialyl Lewis x tetrasaccharide (sLex) to its O-linked glycans, for its high-affinity binding activity. Aberrant expression of this gene and polymorphisms in this gene are associated with defects in the innate and adaptive immune response. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Apr 2011]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
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        "mined_o_glycosites": 1,
        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 10,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 10,
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        "reported_fully_resolved_glycans": 6,
        "reported_phosphosites": 2,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 686,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 10,
        "disease_count": 1,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2Y0;B4DQC3;B7Z5C7;J3KMX6;Q12775;Q6GTW7;Q8N7J7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0001618 virus receptor activity;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0044853 plasma membrane raft;GO:0001931 uropod",
        "go_biological_process": "GO:0050902 leukocyte adhesive activation;GO:0007155 cell adhesion;GO:0050900 leukocyte migration;GO:0050901 leukocyte tethering or rolling;GO:0071354 cellular response to interleukin-6",
        "synthesized_glycan_count": 0,
        "hit_score": 13.2,
        "record_id": "Q14242-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100010010001.111.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A4QPB2-1",
        "uniprot_id": [
            {
                "id": "LRP5L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A4QPB2",
                "type": "external"
            }
        ],
        "mass": 28483.0,
        "length": 252,
        "protein_name": "Low-density lipoprotein receptor-related protein 5-like protein",
        "gene_name": "LRP5L",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "LRP5L",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 5-like protein; LRP-5-like",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 8,
        "publication_id_list": "19531498;29242379;30410026;32387766;32488085;32983136;33392160;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "B0QYF3;B0QYF4;B2RPI5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "A4QPB2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q08431-1",
        "uniprot_id": [
            {
                "id": "MFGM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q08431",
                "type": "external"
            }
        ],
        "mass": 43105.0,
        "length": 387,
        "protein_name": "Lactadherin",
        "gene_name": "MFGE8",
        "organism": "Human",
        "refseq_name": "lactadherin isoform b precursor",
        "refseq_ac": [
            {
                "id": "NP_001108086",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001108086",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MFGE8",
        "gene_names_refseq": "BA46; EDIL1; HMFG; HsT19888; MFG-E8; MFGE8; MFGM; OAcGD3S; SED1; SPAG10; hP47",
        "protein_names_uniprotkb": "Lactadherin; Breast epithelial antigen BA46; HMFG; MFG-E8; MFGM; Milk fat globule-EGF factor 8; SED1",
        "protein_names_refseq": "O-acetyl disialoganglioside synthase; breast epithelial antigen BA46; lactadherin isoform b precursor; lactadherin; medin; milk fat globule-EGF factor 8 protein; sperm associated antigen 10; sperm surface protein hP47",
        "tax_id": 9606,
        "disease": "temporal arteritis (Disease Ontology:DOID:13375)",
        "pathway": " (hsa:4240);  (R-HSA-381426);  (R-HSA-8957275);  (R-HSA-977225);  (R-HSA-9927426)",
        "pathway_count": 5,
        "publication_count": 180,
        "publication_id_list": "10.1101/2023.09.13.557529;10026136;10077652;10097139;10218588;10319874;10391242;10411933;10512690;10583407;10614670;10681634;10810289;10898936;10912521;10951195;10956649;10990447;11158056;11237011;11250653;11264294;11278841;11316783;11401442;11467836;11522292;11590439;11606061;11739083;11751371;11788658;118839;12241545;12379487;12454989;12466191;1270801;12810533;12904166;1370451;1383255;14506261;14567678;15064394;15126567;15308688;15469690;15485880;15525596;15642270;15962837;16174740;16799559;16912206;17047378;17249697;17312271;17425515;17985932;18065497;18070888;18077418;1837051;18449172;18484335;1849145;18780401;19011241;1909932;19204935;19658395;19828817;20166139;20676056;20807650;2118650;2195544;22065755;22131221;23090970;23813966;2409350;24190977;2476804;2479552;24833601;24893886;25523424;25892735;26018760;26091039;26375851;26417681;26668317;26686862;26807092;26992070;27600516;27862975;279930;28514659;2900981;29242379;29314611;29331515;29557506;29741879;29786170;3035556;30429286;3053705;30626607;3080684;3094007;31154438;3142462;31611695;31844290;32125861;32157095;32350084;32387766;32488085;32502341;32938616;33592498;33936100;33968037;34171305;34509645;35051231;35251023;35289036;35561310;35580925;35874702;36241641;36284347;3675579;37074911;37933040;38173019;38199575;38332689;38431242;40596516;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;8033412;8097946;8114934;8159701;8464497;8490014;8639264;8781553;8817670;8870004;8894645;8964575;9006323;9054935;9260929;9497324;9535276;9709957;9733769;9786878;9862427;9922210",
        "class_list": "",
        "function": "Expression and clinical association of MFG-E8 and TAM receptors in diabetic patients with different stages of microvascular complication: An experimental study., [RefSeq, PubMed]; Lactadherin immunoblockade in small extracellular vesicles inhibits sEV-mediated increase of pro-metastatic capacities. Publication Status: Online-Only, [RefSeq, PubMed]; MFG-E8 induces epithelial-mesenchymal transition and anoikis resistance to promote the metastasis of pancreatic cancer cells., [RefSeq, PubMed]; Main constituent of aortic medial amyloid., [UniProtKB, PubMed]; PTP1B mediates the inhibitory effect of MFGE8 on insulin signaling through the beta5 integrin., [RefSeq, PubMed]; Plays an important role in the maintenance of intestinal epithelial homeostasis and the promotion of mucosal healing. Promotes VEGF-dependent neovascularization (By similarity). Contributes to phagocytic removal of apoptotic cells in many tissues. Specific ligand for the alpha-v/beta-3 and alpha-v/beta-5 receptors. Also binds to phosphatidylserine-enriched cell surfaces in a receptor-independent manner. Zona pellucida-binding protein which may play a role in gamete interaction., [UniProtKB, PubMed]; Potent CTLs can be induced against tumor cells in an environment of lower levels of systemic MFG-E8., [RefSeq, PubMed]; This gene encodes a preproprotein that is proteolytically processed to form multiple protein products. The major encoded protein product, lactadherin, is a membrane glycoprotein that promotes phagocytosis of apoptotic cells. This protein has also been implicated in wound healing, autoimmune disease, and cancer. Lactadherin can be further processed to form a smaller cleavage product, medin, which comprises the major protein component of aortic medial amyloid (AMA). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 69,
        "disease_count": 1,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6M7;F5GZN3;Q53FU9;Q7Z3D2;Q9BTL9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding;GO:0001786 phosphatidylserine binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0016020 membrane;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0007155 cell adhesion;GO:0007338 single fertilization;GO:0043277 apoptotic cell clearance",
        "synthesized_glycan_count": 0,
        "hit_score": 25.7,
        "record_id": "Q08431-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9P2D3-1",
        "uniprot_id": [
            {
                "id": "HTR5B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9P2D3",
                "type": "external"
            }
        ],
        "mass": 224302.0,
        "length": 2071,
        "protein_name": "HEAT repeat-containing protein 5B",
        "gene_name": "HEATR5B",
        "organism": "Human",
        "refseq_name": "HEAT repeat-containing protein 5B",
        "refseq_ac": [
            {
                "id": "NP_061897",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061897",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HEATR5B; KIAA1414; p200a; p200",
        "gene_names_refseq": "HEATR5B; p200a; p200",
        "protein_names_uniprotkb": "HEAT repeat-containing protein 5B",
        "protein_names_refseq": "HEAT repeat-containing protein 5B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54497)",
        "pathway_count": 1,
        "publication_count": 78,
        "publication_id_list": "11237011;15758025;17975119;18691976;19023099;20058876;20068231;22544926;22898188;23186163;24714562;24715725;25505266;25576301;26154972;26811146;26992070;27600516;27862975;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30429286;30524438;31217245;31844290;32157095;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33592498;33691108;33824466;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34509645;34561969;34932366;35051231;35561310;35580925;36010968;36215666;36241641;36284347;38240799;38253038",
        "class_list": "",
        "function": "Biallelic hypomorphic mutations in HEATR5B, encoding HEAT repeat-containing protein 5B, in a neurological syndrome with pontocerebellar hypoplasia., [RefSeq, PubMed]; Component of clathrin-coated vesicles (PubMed:15758025). Component of the aftiphilin/p200/gamma-synergin complex, which plays roles in AP1G1/AP-1-mediated protein trafficking including the trafficking of transferrin from early to recycling endosomes, and the membrane trafficking of furin and the lysosomal enzyme cathepsin D between the trans-Golgi network (TGN) and endosomes (PubMed:15758025)., [UniProtKB, PubMed]; Fast-evolving cofactors regulate the role of HEATR5 complexes in intra-Golgi trafficking., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 39,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MDU8;Q7Z3B2;Q9NVL7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol;GO:0016020 membrane;GO:0048471 perinuclear region of cytoplasm;GO:0030136 clathrin-coated vesicle",
        "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0008104 intracellular protein localization;GO:0042147 retrograde transport, endosome to Golgi",
        "synthesized_glycan_count": 0,
        "hit_score": 8.1,
        "record_id": "Q9P2D3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96PB8-1",
        "uniprot_id": [
            {
                "id": "LRC3B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96PB8",
                "type": "external"
            }
        ],
        "mass": 29275.0,
        "length": 259,
        "protein_name": "Leucine-rich repeat-containing protein 3B",
        "gene_name": "LRRC3B",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 3B precursor",
        "refseq_ac": [
            {
                "id": "NP_001304737",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304737",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC3B; LRP15; PRO221",
        "gene_names_refseq": "LRP15; LRRC3B",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 3B; Leucine-rich repeat protein 15",
        "protein_names_refseq": "leucine-rich repeat protein 15; leucine-rich repeat protein LRP15; leucine-rich repeat-containing protein 3B precursor; leucine-rich repeat-containing protein 3B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:116135)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;12975309;18377727;18757430;18815942;22101383;22321817;24839112;26276358;27118644;32938616;36798137;37217939",
        "class_list": "",
        "function": "Data suggest that LRRC3B gene could be involved in the process of carcinogenesis as a tumor suppressor gene., [RefSeq, PubMed]; LRRC3B and its promoter hypomethylation status predicts response to anti-PD-1 based immunotherapy. Publication Status: Online-Only, [RefSeq, PubMed]; LRRC3B gene expression and promoter hypermethylation in breast carcinomas, [RefSeq, PubMed]; LRRC3B may be a novel methylation-sensitive tumor suppressor gene in CRC. LRRC3B methylation has significant tumor specificity and may be a biomarker of CRC., [RefSeq, PubMed]; LRRC3B may serve as an important tumor suppressor in non-small-cell lung cancer, [RefSeq, PubMed]; Suggest that LRRC3B is a putative tumor suppressor gene that is silenced in gastric cancers by epigenetic mechanisms and that LRRC3B silencing in cancer may play an important role in tumor escape from immune surveillance, [RefSeq, PubMed]; The LRRC3B gene promoter was methylated in 43% of clear cell renal carcinoma samples., [RefSeq, PubMed]; The expression of LRP15 is controlled by methylation in its promoter in HeLa cells, and LRP15 confers resistance to ultraviolet rays damage and accelerates the DNA repair rate., [RefSeq, PubMed]; The expression of LRRC3B is downregulated in non-small cell lung cancer compared with normal epithelial cells., [RefSeq, PubMed]; The protein encoded by this gene is a tumor suppressor, with lowered expression levels found in gastric, renal, colorectal, lung, and breast cancer tissues. The promoter of this gene is frequently hypermethylated in these cancer tissues, although the hypermethylation does not appear to be the cause of the reduced expression of this gene. Several transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Dec 2015]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5M8T0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q96PB8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P08254-1",
        "uniprot_id": [
            {
                "id": "MMP3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P08254",
                "type": "external"
            }
        ],
        "mass": 53977.0,
        "length": 477,
        "protein_name": "Stromelysin-1",
        "gene_name": "MMP3",
        "organism": "Human",
        "refseq_name": "stromelysin-1 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_002413",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002413",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MMP3; STMY1",
        "gene_names_refseq": "CHDS6; MMP-3; MMP3; SL-1; STMY1; STMY; STR1",
        "protein_names_uniprotkb": "Stromelysin-1; 3.4.24.17; MMP-3; Matrix metalloproteinase-3; SL-1; Transin-1",
        "protein_names_refseq": "matrix metalloproteinase 3 (stromelysin 1, progelatinase); proteoglycanase; stromelysin-1 preproprotein; stromelysin-1; transin-1",
        "tax_id": 9606,
        "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); stroke (Disease Ontology:DOID:0051061); atrial fibrillation (Disease Ontology:DOID:0060224); thrombosis (Disease Ontology:DOID:0060903); Parkinsonism (Disease Ontology:DOID:0080855); immunoglobulin light chain amyloidosis (Disease Ontology:DOID:0080933); gastric ulcer (Disease Ontology:DOID:10808); Alport syndrome (Disease Ontology:DOID:10983); cartilage disease (Disease Ontology:DOID:1222); primary biliary cholangitis (Disease Ontology:DOID:12236); Sjogren's syndrome (Disease Ontology:DOID:12894); carotid stenosis (Disease Ontology:DOID:13001); crescentic glomerulonephritis (Disease Ontology:DOID:13139); lung cancer (Disease Ontology:DOID:1324); von Hippel-Lindau disease (Disease Ontology:DOID:14175); cognitive disorder (Disease Ontology:DOID:1561); breast cancer (Disease Ontology:DOID:1612); colon cancer (Disease Ontology:DOID:219); arteriosclerosis (Disease Ontology:DOID:2349); Takayasu's arteritis (Disease Ontology:DOID:2508); glomerulonephritis (Disease Ontology:DOID:2921); allergic contact dermatitis (Disease Ontology:DOID:3042); coronary artery disease (Disease Ontology:DOID:3393); systemic scleroderma (Disease Ontology:DOID:418); conjunctivochalasis (Disease Ontology:DOID:4250); renal cell carcinoma (Disease Ontology:DOID:4450); esophagus adenocarcinoma (Disease Ontology:DOID:4914); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); periodontitis (Disease Ontology:DOID:824); cataract (Disease Ontology:DOID:83); osteoarthritis (Disease Ontology:DOID:8398); polymyalgia rheumatica (Disease Ontology:DOID:853); degenerative disc disease (Disease Ontology:DOID:90); psoriatic arthritis (Disease Ontology:DOID:9008); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); coronary heart disease, susceptibility to, 6 (MONDO:MONDO:0013765)",
        "pathway": " (hsa:4314);  (R-HSA-1442490);  (R-HSA-1474228);  (R-HSA-1592389);  (R-HSA-2022090);  (R-HSA-2179392);  (R-HSA-6785807);  (R-HSA-9009391)",
        "pathway_count": 8,
        "publication_count": 342,
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        "class_list": "",
        "function": "Association of MMP3, MMP14, and MMP25 gene polymorphisms with cerebral stroke risk: a case-control study. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic Variants in Matrix Metalloproteinases MMP3 (rs3025058) and MMP9 (rs3918242) Associated with Colonic Diverticulosis. Publication Status: Online-Only, [RefSeq, PubMed]; Growth Differentiation Factor 15 and Matrix Metalloproteinase 3 in Plasma as Biomarkers for Neuropathy and Nephropathy in Type 1 Diabetes. Publication Status: Online-Only, [RefSeq, PubMed]; Metalloproteinase with a rather broad substrate specificity that can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates different molecules including growth factors, plasminogen or other matrix metalloproteinases such as MMP9 (PubMed:11029580, PubMed:1371271). Once released into the extracellular matrix (ECM), the inactive pro-enzyme is activated by the plasmin cascade signaling pathway (PubMed:2383557). Also acts intracellularly (PubMed:22265821). For example, in dopaminergic neurons, gets activated by the serine protease HTRA2 upon stress and plays a pivotal role in DA neuronal degeneration by mediating microglial activation and alpha-synuclein/SNCA cleavage (PubMed:21330369). In addition, plays a role in immune response and possesses antiviral activity against various viruses such as vesicular stomatitis virus, influenza A virus (H1N1) and human herpes virus 1 (PubMed:35940311). Mechanistically, translocates from the cytoplasm into the cell nucleus upon virus infection to influence NF-kappa-B activities (PubMed:35940311)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. This gene encodes an enzyme which degrades fibronectin, laminin, collagens III, IV, IX, and X, and cartilage proteoglycans. The enzyme is thought to be involved in wound repair, progression of atherosclerosis, and tumor initiation. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008]., [RefSeq]; Smooth muscle cell-specific matrix metalloproteinase 3 deletion reduces osteogenic transformation and medial artery calcification., [RefSeq, PubMed]; Transcriptomic discovery of a theranostic signature (SERPINE1/MMP3/COL1A1/SPP1) for head and neck squamous cell carcinomas and identification of antrocinol as a candidate drug., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 41,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R8B8;Q3B7S0;Q6GRF8",
        "ec_number_list": [
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "3.4.22.43",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.43",
                "type": "external"
            },
            {
                "id": "3.4.21.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.34",
                "type": "external"
            },
            {
                "id": "3.4.24.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7",
                "type": "external"
            },
            {
                "id": "3.4.21.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4",
                "type": "external"
            },
            {
                "id": "3.4.22.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15",
                "type": "external"
            },
            {
                "id": "3.4.22.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.4.21.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37",
                "type": "external"
            },
            {
                "id": "3.4.24.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24",
                "type": "external"
            },
            {
                "id": "3.4.24.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17",
                "type": "external"
            },
            {
                "id": "3.4.24.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23",
                "type": "external"
            },
            {
                "id": "3.4.24.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22",
                "type": "external"
            },
            {
                "id": "3.4.24.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.19",
                "type": "external"
            },
            {
                "id": "3.4.24.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "3.4.21.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.1",
                "type": "external"
            },
            {
                "id": "3.4.24.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34",
                "type": "external"
            },
            {
                "id": "3.4.22.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27",
                "type": "external"
            },
            {
                "id": "3.4.24.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65",
                "type": "external"
            },
            {
                "id": "3.4.22.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0006508 proteolysis;GO:0022617 extracellular matrix disassembly;GO:0030198 extracellular matrix organization;GO:0045087 innate immune response;GO:1904645 response to amyloid-beta",
        "synthesized_glycan_count": 0,
        "hit_score": 34.6,
        "record_id": "P08254-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y663-1",
        "uniprot_id": [
            {
                "id": "HS3SA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y663",
                "type": "external"
            }
        ],
        "mass": 44900.0,
        "length": 406,
        "protein_name": "Heparan sulfate glucosamine 3-O-sulfotransferase 3A1",
        "gene_name": "HS3ST3A1",
        "organism": "Human",
        "refseq_name": "heparan sulfate glucosamine 3-O-sulfotransferase 3A1",
        "refseq_ac": [
            {
                "id": "NP_006033",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006033",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HS3ST3A1; 3OST3A1; HS3ST3A; PRO6180",
        "gene_names_refseq": "3-OST-3A; 3OST3A1; HS3ST3A1",
        "protein_names_uniprotkb": "Heparan sulfate glucosamine 3-O-sulfotransferase 3A1; 2.8.2.30; 3-OST-3A; Heparan sulfate 3-O-sulfotransferase 3A1; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1; h3-OST-3A",
        "protein_names_refseq": "heparan sulfate (glucosamine) 3-O-sulfotransferase 3A1; heparan sulfate 3-O-sulfotransferase 3A1; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3A1; heparan sulfate glucosamine 3-O-sulfotransferase 3A1; heparin-glucosamine 3-O-sulfotransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9955);  (R-HSA-2022928)",
        "pathway_count": 2,
        "publication_count": 48,
        "publication_id_list": "10318803;10520990;10608887;10639137;10644753;10677367;10716625;11087757;11169766;11237011;11274177;11279150;11390981;12138164;12492399;12975309;15082721;15304505;15607426;16343444;20554947;21700882;22475533;26410339;27041583;28132690;28148688;28618938;29493099;30471091;31611695;32350084;32983136;33159882;33592498;33968037;33981976;35051231;35251023;35676258;36010968;7601448;9346953;9463333;9535912;9915799;9988767;9988768",
        "class_list": "glycogene",
        "function": "Decreased in pre-eclamptic placental tissue, [RefSeq, PubMed]; Detection of MUC1 and HS3ST2 promoter methylation status appears to be useful molecular markers for assessing the progressive state of the disease and could be helpful in discriminating breast cancer molecular subtypes. These results validate the methylation-based microarray analysis, thus trust their output in the future., [RefSeq, PubMed]; Genetic variants of HS3ST3A1 and HS3ST3B1 are associated with Plasmodium falciparum parasitaemia. Publication Status: Online-Only, [RefSeq, PubMed]; Heparan sulfate biosynthetic enzymes are key components in generating a myriad of distinct heparan sulfate fine structures that carry out multiple biologic activities. The enzyme encoded by this gene is a member of the heparan sulfate biosynthetic enzyme family. It is a type II integral membrane protein and possesses heparan sulfate glucosaminyl 3-O-sulfotransferase activity. The sulfotransferase domain of this enzyme is highly similar to the same domain of heparan sulfate D-glucosaminyl 3-O-sulfotransferase 3B1, and these two enzymes sulfate an identical disaccharide. This gene is widely expressed, with the most abundant expression in liver and placenta. [provided by RefSeq, Dec 2014]., [RefSeq]; Our findings define 3-OST3A as a novel regulator of breast cancer pathogenicity, displaying tumor-suppressive or oncogenic activities in a cell- and tumor-dependent context, and demonstrate the clinical value of the HS-O-sulfotransferase 3-OST3A as a prognostic marker in HER2+ patients., [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to an N-unsubstituted glucosamine linked to a 2-O-sulfo iduronic acid unit on heparan sulfate (PubMed:10520990, PubMed:10608887, PubMed:15304505, PubMed:9988768). Catalyzes the O-sulfation of glucosamine in IdoUA2S-GlcNS and also in IdoUA2S-GlcNH2 (PubMed:10520990, PubMed:15304505, PubMed:9988768). The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry (PubMed:10520990). Unlike HS3ST1/3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate (PubMed:10520990)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 23,
        "reported_glycation": 0,
        "reported_snv": 676,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7N2",
        "ec_number_list": [
            {
                "id": "2.8.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.23",
                "type": "external"
            },
            {
                "id": "2.8.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-",
                "type": "external"
            },
            {
                "id": "2.8.2.29",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.29",
                "type": "external"
            },
            {
                "id": "2.8.2.30",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.30",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008146 sulfotransferase activity;GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0016020 membrane;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0006024 glycosaminoglycan biosynthetic process;GO:0001658 branching involved in ureteric bud morphogenesis;GO:0015012 heparan sulfate proteoglycan biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q9Y663-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000010000.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P33991-1",
        "uniprot_id": [
            {
                "id": "MCM4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P33991",
                "type": "external"
            }
        ],
        "mass": 96558.0,
        "length": 863,
        "protein_name": "DNA replication licensing factor MCM4",
        "gene_name": "MCM4",
        "organism": "Human",
        "refseq_name": "DNA replication licensing factor MCM4",
        "refseq_ac": [
            {
                "id": "NP_005905",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005905",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MCM4; CDC21",
        "gene_names_refseq": "CDC21; CDC54; IMD54; MCM4; NKCD; NKGCD; P1-CDC21; hCdc21",
        "protein_names_uniprotkb": "DNA replication licensing factor MCM4; 3.6.4.12; CDC21 homolog; P1-CDC21",
        "protein_names_refseq": "DNA replication licensing factor MCM4; homolog of S. pombe cell devision cycle 21; minichromosome maintenance deficient 4",
        "tax_id": 9606,
        "disease": "immunodeficiency 54 (Disease Ontology:DOID:0111967)",
        "pathway": " (hsa:4173);  (R-HSA-176187);  (R-HSA-176974);  (R-HSA-68867);  (R-HSA-68949);  (R-HSA-68962);  (R-HSA-69052)",
        "pathway_count": 7,
        "publication_count": 206,
        "publication_id_list": "10.1101/2023.09.13.557529;10051570;10373362;10373557;10501844;10518787;10523313;10757793;10777662;10827953;10846177;10859164;10882098;10884341;11095689;11125146;11237011;11248027;11390642;11454864;11562349;11739726;11931757;12045100;12364596;12399544;12578958;12676583;12676925;12714602;12759351;12791985;12963847;14500360;14603323;14605214;14624239;14672932;15190204;15226314;15302935;15707391;15743907;15833913;16327781;16407120;16517729;16519687;16824194;16899510;16964243;17005684;17081983;17234884;17296731;17417653;17485488;17924679;18220336;18452278;18480045;18669648;18691976;19608861;19651622;19664994;19690332;19896182;20068231;20934997;21406692;22354167;22354170;22424782;22499342;23186163;23481700;23603117;23851460;24366607;24714562;24715725;25231993;25418920;25505266;25576301;25645385;25661590;25892735;26154972;26222030;26375851;26728094;26811146;26992070;27249176;27401717;27600516;27846572;27862975;27920218;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29769354;29786170;29789417;30069701;30315122;30397120;30410026;30484775;30524438;30779550;30833945;31154438;31217245;31222486;31373491;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32453425;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33465208;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34561969;34694004;34700328;34725712;34932366;34961841;35051231;35138101;35154160;35251023;35318648;35561310;35580925;35585232;35830849;36010968;36215666;36241641;36284347;36581221;37938771;38216092;38665916;39276458;40596516;7601140;7734418;8196638;8265339;8943031;9278511;9278512;9284934;9305914;9465298;9635433;9660782",
        "class_list": "",
        "function": "Acts as a component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:34694004, PubMed:34700328, PubMed:35585232, PubMed:9305914). The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity (PubMed:16899510, PubMed:25661590, PubMed:32453425, PubMed:9305914)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Identification of MCM4 and PRKDC as new regulators of osteosarcoma cell dormancy based on 3D cell cultures., [RefSeq, PubMed]; Identification of MCM4 as a Prognostic Marker of Hepatocellular Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; MCM4 potentiates evasion of hepatocellular carcinoma from sorafenib-induced ferroptosis through Nrf2 signaling pathway., [RefSeq, PubMed]; Minichromosome Maintenance 4 Is Associated with Cancer Stemness and Poor Survival of Patients with Gastric Cancer., [RefSeq, PubMed]; The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 6 and 7 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. The phosphorylation of this protein by CDC2 kinase reduces the DNA helicase activity and chromatin binding of the MCM complex. This gene is mapped to a region on the chromosome 8 head-to-head next to the PRKDC/DNA-PK, a DNA-activated protein kinase involved in the repair of DNA double-strand breaks. Alternatively spliced transcript variants encoding the same protein have been reported. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
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        "total_reported_n_glycosites": 1,
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        "reported_mutagensis": 1,
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        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NEH1;Q99658",
        "ec_number_list": [
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
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            {
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            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
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                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
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                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
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                "id": "5.6.2.-",
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                "id": "2.3.2.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
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            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
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                "id": "3.1.13.1",
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                "id": "5.6.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
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        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0003697 single-stranded DNA binding;GO:0003678 DNA helicase activity;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016020 membrane;GO:0000781 chromosome, telomeric region;GO:0042555 MCM complex",
        "go_biological_process": "GO:0030174 regulation of DNA-templated DNA replication initiation;GO:0006271 DNA strand elongation involved in DNA replication;GO:0006260 DNA replication;GO:1902975 mitotic DNA replication initiation;GO:0000727 double-strand break repair via break-induced replication",
        "synthesized_glycan_count": 0,
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        "record_id": "P33991-1",
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    },
    {
        "uniprot_canonical_ac": "O15031-1",
        "uniprot_id": [
            {
                "id": "PLXB2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15031",
                "type": "external"
            }
        ],
        "mass": 205127.0,
        "length": 1838,
        "protein_name": "Plexin-B2",
        "gene_name": "PLXNB2",
        "organism": "Human",
        "refseq_name": "plexin-B2 isoform 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_036533",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036533",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLXNB2; KIAA0315",
        "gene_names_refseq": "MM1; Nbla00445; PLEXB2; PLXNB2; dJ402G11.3; lncFAL",
        "protein_names_uniprotkb": "Plexin-B2; MM1",
        "protein_names_refseq": "ferroptosis-associated lncRNA; plexin-B2 isoform 3 precursor",
        "tax_id": 9606,
        "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:23654)",
        "pathway_count": 1,
        "publication_count": 105,
        "publication_id_list": "10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;11237011;12183458;12533544;15184888;17074750;18477386;19159218;19349973;20068231;22424782;22544926;22661428;23090970;23481700;24190977;24715725;25502872;25576301;25645385;25813380;25892735;26154972;26375851;26992070;27452731;27543614;27600516;27726376;27846572;27920218;28228285;28832583;28834231;28904123;29100074;29242379;29314611;29391424;29393594;29493099;29557506;29632046;29741879;29786170;30315122;30429286;31217245;31611695;31844290;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32510170;32897882;32938616;32983136;33043033;33123756;33141586;33298915;33392160;33465208;33537174;33592498;33633747;33717175;33912179;33936100;33968037;34019948;34114565;34171305;34185709;34211107;34357683;34405274;34433824;34509645;34932366;35051231;35154160;35251023;35289036;35318648;35508657;35580925;36010968;36215666;36241641;36284347;36581221;37074911;37217939;37632633;37938771;38295715;38458752;38665916;39048831",
        "class_list": "",
        "function": "Biallelic variants in Plexin B2 (PLXNB2) cause amelogenesis imperfecta, hearing loss and intellectual disability. Publication Status: Online-Only, [RefSeq, PubMed]; Cell surface receptor for SEMA4C, SEMA4D and SEMA4G that plays an important role in cell-cell signaling (By similarity). Plays a role in glutamatergic synapse development and is required for SEMA4A-mediated excitatory synapse development (By similarity). Binding to class 4 semaphorins promotes downstream activation of RHOA and phosphorylation of ERBB2 at 'Tyr-1248' (By similarity). Also acts as a cell surface receptor for angiogenin (ANG); promoting ANG endocytosis and translocation to the cytoplasm or nucleus (PubMed:29100074, PubMed:32510170). Required for normal differentiation and migration of neuronal cells during brain corticogenesis and for normal embryonic brain development (By similarity). Regulates the migration of cerebellar granule cells in the developing brain (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12183458). Plays a role in axon guidance, invasive growth and cell migration (PubMed:15184888). May modulate the activity of RAC1 and CDC42 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Colorectal Cancer-Associated Myofibroblasts Exhibit Enhanced Angiogenin Expression and Signaling via the PLXNB2 Receptor., [RefSeq, PubMed]; Expression analysis, clinical significance and potential function of PLXNB2 in acute myeloid leukaemia., [RefSeq, PubMed]; In vivo interaction screening reveals liver-derived constraints to metastasis., [RefSeq, PubMed]; Members of the B class of plexins, such as PLXNB2 are transmembrane receptors that participate in axon guidance and cell migration in response to semaphorins (Perrot et al. (2002) [PubMed 12183458]).[supplied by OMIM, Mar 2008]., [RefSeq]; Plexin B2 associates directly with two members of a recently identified family of Dbl homology/pleckstrin homology containing guanine nucleotide exchange factors for Rho, PDZ-RhoGEF, and Leukemia-associated Rho GEF (LARG)., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
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        "reported_n_glycosites": 14,
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        "reported_n_glycosites_with_glycan": 13,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 14,
        "total_reported_o_glycosites": 5,
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        "total_n_glycosites": 14,
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        "reported_fully_resolved_glycans": 2,
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        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 61,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 161,
        "disease_count": 2,
        "glyco_site_count": 21,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6QRH0;Q7KZU3;Q9BSU7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0017154 semaphorin receptor activity;GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0002116 semaphorin receptor complex;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:1904861 excitatory synapse assembly;GO:0007162 negative regulation of cell adhesion;GO:0010976 positive regulation of neuron projection development;GO:0043087 regulation of GTPase activity;GO:0071526 semaphorin-plexin signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 28.6,
        "record_id": "O15031-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6DN12-1",
        "uniprot_id": [
            {
                "id": "MCTP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6DN12",
                "type": "external"
            }
        ],
        "mass": 99596.0,
        "length": 878,
        "protein_name": "Multiple C2 and transmembrane domain-containing protein 2",
        "gene_name": "MCTP2",
        "organism": "Human",
        "refseq_name": "multiple C2 and transmembrane domain-containing protein 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001153115",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153115",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MCTP2",
        "gene_names_refseq": "MCTP2",
        "protein_names_uniprotkb": "Multiple C2 and transmembrane domain-containing protein 2",
        "protein_names_refseq": "multiple C2 and transmembrane domain-containing protein 2 isoform 2; multiple C2 and transmembrane domain-containing protein 2; multiple C2 domains, transmembrane 2; multiple C2-domains with two transmembrane regions 2 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55784)",
        "pathway_count": 1,
        "publication_count": 41,
        "publication_id_list": "10.1074/mcp.M114.046862;11237011;15528213;17924679;18367154;18669648;19223264;23773997;25813380;25892735;26375851;26992070;27862975;28832583;28834231;29242379;29314611;29557506;29632711;29769354;30429286;30484775;31844290;32157095;32502341;32938616;32983136;33198772;33392160;33592498;33717175;33826368;33912179;33968037;35051231;35580925;36215666;36241641;36581221;38494582;38547502",
        "class_list": "",
        "function": "CircMCTP2 enhances the progression of bladder cancer by regulating the miR-99a-5p/FZD8 axis. Publication Status: Online-Only, [RefSeq, PubMed]; Circular RNA MCTP2 inhibits cisplatin resistance in gastric cancer by miR-99a-5p-mediated induction of MTMR3 expression. Publication Status: Online-Only, [RefSeq, PubMed]; Human genetics of face recognition: discovery of MCTP2 mutations in humans with face blindness (congenital prosopagnosia)., [RefSeq, PubMed]; MCTPs are evolutionarily conserved C2 domain proteins that are unusual in that the C2 domains are anchored in the membrane by two closely spaced transmembrane regions and represent Ca(2+)-binding but not phospholipid-binding modules, [RefSeq, PubMed]; Might play a role in the development of cardiac outflow tract., [UniProtKB, PubMed]; Multiple C2 domain-containing transmembrane proteins promote lipid droplet biogenesis and growth at specialized endoplasmic reticulum subdomains., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The present study suggested that MCPT2 gene as aputative susceptibility gene for schizophrenia of Scandinavian origin. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RRC2;C6G483;C6G484;Q49AB0;Q8TAX2;Q9NUS2;Q9NUW7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016020 membrane;GO:0030672 synaptic vesicle membrane",
        "go_biological_process": "GO:0019722 calcium-mediated signaling;GO:0046928 regulation of neurotransmitter secretion",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q6DN12-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H9H5-1",
        "uniprot_id": [
            {
                "id": "MA6D1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H9H5",
                "type": "external"
            }
        ],
        "mass": 21005.0,
        "length": 199,
        "protein_name": "MAP6 domain-containing protein 1",
        "gene_name": "MAP6D1",
        "organism": "Human",
        "refseq_name": "MAP6 domain-containing protein 1",
        "refseq_ac": [
            {
                "id": "NP_079147",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079147",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAP6D1",
        "gene_names_refseq": "MAP6D1; MAPO6D1; SL21",
        "protein_names_uniprotkb": "MAP6 domain-containing protein 1; 21 kDa STOP-like protein; SL21",
        "protein_names_refseq": "21 kDa STOP-like protein; MAP6 domain-containing protein 1; STOP-Like protein 21 kD",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79929)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;16837464;28657654;29331515;32157095;35051231;38538594",
        "class_list": "",
        "function": "May have microtubule-stabilizing activity., [UniProtKB]; This gene encodes a protein highly similar to the mouse MAP6 domain containing 1 protein, which is related to the STOP proteins. Based on the study of the mouse protein, the encoded protein may function as a calmodulin-regulated neuronal protein that binds and stabilizes microtubules but also associates with the Golgi membranes through N-terminal palmitoylation. [provided by RefSeq, Oct 2008]., [RefSeq]; This paper describes the conserved domains, localization and function of the mouse MAP6D1 protein. It also compared the sequences of the related proteins in mouse, human and other species., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "reported_phosphosites": 2,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005798 Golgi-associated vesicle;GO:0005874 microtubule;GO:0005801 cis-Golgi network",
        "go_biological_process": "GO:0000226 microtubule cytoskeleton organization;GO:0030705 cytoskeleton-dependent intracellular transport;GO:0070507 regulation of microtubule cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q9H9H5-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y5B9-1",
        "uniprot_id": [
            {
                "id": "SP16H_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y5B9",
                "type": "external"
            }
        ],
        "mass": 119914.0,
        "length": 1047,
        "protein_name": "FACT complex subunit SPT16",
        "gene_name": "SUPT16H",
        "organism": "Human",
        "refseq_name": "FACT complex subunit SPT16",
        "refseq_ac": [
            {
                "id": "NP_009123",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009123",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SUPT16H; FACT140; FACTP140",
        "gene_names_refseq": "CDC68; FACTP140; NEDDFAC; SPT16/CDC68; SPT16; SUPT16H",
        "protein_names_uniprotkb": "FACT complex subunit SPT16; Chromatin-specific transcription elongation factor 140 kDa subunit; FACT 140 kDa subunit; FACTp140; Facilitates chromatin transcription complex subunit SPT16; hSPT16",
        "protein_names_refseq": "FACT 140 kDa subunit; FACT complex subunit SPT16; chromatin-specific transcription elongation factor 140 kDa subunit; facilitates chromatin remodeling 140 kDa subunit; facilitates chromatin transcription complex subunit SPT16; hSPT16; suppressor of Ty 16 homolog",
        "tax_id": 9606,
        "disease": "neurodevelopmental disorder with dysmorphic facies and thin corpus callosum (Disease Ontology:DOID:0070469)",
        "pathway": " (hsa:11198);  (R-HSA-112382);  (R-HSA-167152);  (R-HSA-167200);  (R-HSA-167238);  (R-HSA-167243);  (R-HSA-167246);  (R-HSA-167287);  (R-HSA-167290);  (R-HSA-674695);  (R-HSA-6796648);  (R-HSA-6804756);  (R-HSA-75955);  (R-HSA-9943411)",
        "pathway_count": 14,
        "publication_count": 224,
        "publication_id_list": "10199401;10199952;10421373;10435622;10500146;10570149;10604467;10673500;10673501;10710310;10757782;10792464;10866664;10884347;10912001;10984493;11237011;11239457;11313498;11313499;11350971;11447225;11511362;11546806;11551930;11740489;11780126;11859374;11884399;11971958;11988847;12064478;12393879;12676794;12682017;12702766;12851404;12914926;12934006;14660563;14701750;14702041;15053879;15489290;15647753;15781865;15866171;16263726;16322561;16372014;16682447;16713563;17081983;17108107;17234882;17349958;17433364;17591690;17717186;18042460;18490454;18510355;18669648;18802091;18991276;19121998;1939271;19413330;19608861;19651622;19664994;19691289;19952111;19965871;20068231;20112406;20159561;20211137;20959462;21317932;21406692;22012619;22046413;22223895;22544926;22569126;22898188;22922743;22988298;23000554;23186163;23301498;23481700;23485397;23538671;23676219;23783831;24029068;24145406;24366607;2449431;24554720;24662513;24714562;24715725;24874608;25218447;25429106;25469497;25561469;25576301;25645385;25712099;25772364;25880248;25892735;26154972;26659056;26768311;26992070;27452731;27499292;27543614;27600516;27661449;27846572;27862975;27920218;28063628;28218747;28228285;28510447;28832583;28834231;28904123;29242379;29317506;29351928;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30379171;30410026;30429286;30484775;30524438;30779550;31020640;31217245;31844290;31924697;32119511;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32522876;32897882;32938616;32983136;33091337;33141586;33214551;33298915;33392160;33465208;33537174;33592498;33633747;33691108;33717175;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34561969;34725712;34932366;35051231;35138101;35318648;35561310;35580925;36010968;36215666;36241641;36255738;36284347;36577379;36769360;36801613;37217939;37938771;38665916;39990658;40596516;7660122;7660129;7660130;7853496;8370526;9063748;9450929;9489704;9836642;9925639",
        "class_list": "",
        "function": "Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II. The FACT complex is probably also involved in phosphorylation of 'Ser-392' of p53/TP53 via its association with CK2 (casein kinase II)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Human FACT subunits coordinate to catalyze both disassembly and reassembly of nucleosomes., [RefSeq, PubMed]; Structural basis for H2A-H2B recognitions by human Spt16., [RefSeq, PubMed]; Supt16 Haploinsufficiency Impairs PI3K/AKT/mTOR/Autophagy Pathway in Human Pluripotent Stem Cells Derived Neural Stem Cells. Publication Status: Online-Only, [RefSeq, PubMed]; The fly homolog of SUPT16H, a gene associated with neurodevelopmental disorders, is required in a cell-autonomous fashion for cell survival., [RefSeq, PubMed]; Transcription of protein-coding genes can be reconstituted on naked DNA with only the general transcription factors and RNA polymerase II. However, this minimal system cannot transcribe DNA packaged into chromatin, indicating that accessory factors may facilitate access to DNA. One such factor, FACT (facilitates chromatin transcription), interacts specifically with histones H2A/H2B to effect nucleosome disassembly and transcription elongation. FACT is composed of an 80 kDa subunit and a 140 kDa subunit; this gene encodes the 140 kDa subunit. [provided by RefSeq, Feb 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6GMT8;Q6P2F1;Q6PJM1;Q9NRX0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0031491 nucleosome binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035101 FACT complex",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006260 DNA replication;GO:0006366 transcription by RNA polymerase II;GO:0006334 nucleosome assembly;GO:0006337 nucleosome disassembly",
        "synthesized_glycan_count": 0,
        "hit_score": 23.3,
        "record_id": "Q9Y5B9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43157-1",
        "uniprot_id": [
            {
                "id": "PLXB1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43157",
                "type": "external"
            }
        ],
        "mass": 232298.0,
        "length": 2135,
        "protein_name": "Plexin-B1",
        "gene_name": "PLXNB1",
        "organism": "Human",
        "refseq_name": "plexin-B1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001123554",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123554",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLXNB1; KIAA0407; PLXN5; SEP",
        "gene_names_refseq": "PLEXIN-B1; PLXN5; PLXNB1; SEP",
        "protein_names_uniprotkb": "Plexin-B1; Semaphorin receptor SEP",
        "protein_names_refseq": "plexin 5; plexin-B1 precursor; semaphorin receptor SEP",
        "tax_id": 9606,
        "disease": "developmental disorder of mental health (Disease Ontology:DOID:0060037); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:5364);  (R-HSA-416482);  (R-HSA-416550);  (R-HSA-416572);  (R-HSA-9013405)",
        "pathway_count": 5,
        "publication_count": 111,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10520995;10652353;11018042;11035813;11283606;11294240;11313914;11742120;11784792;11937491;12101119;12123608;12185584;12196628;12198496;12220504;12433842;12515866;12533544;12577064;12730235;15184888;15210733;15699075;15749160;15951850;16188938;16212495;16219803;16335952;16702230;16799460;16923326;16959974;17064668;17151359;17916560;18025083;18275816;18374420;18411422;18577758;19159218;19212140;19349973;19843518;20877282;21912513;22661716;22665057;23087206;23090970;23096567;23584533;24102721;24190977;25414122;25746724;25813380;27072905;27481945;27852748;28486133;28947137;29242379;29391424;29393594;29557506;29632046;2966156;29671580;29776664;30007591;30418433;30459171;31844290;31848261;31871319;32157095;32350084;32387766;32502341;32938616;33392160;33912179;33936100;33968037;33981976;34171305;35051231;35154160;35170806;35251023;35580925;36215666;37032361;37074911;37901456;3839510;39443302;7937899;8570614;8617235;8702756;8816443;8945468;9308960;9796816",
        "class_list": "",
        "function": "Neurite outgrowth deficits caused by rare PLXNB1 mutation in pediatric bipolar disorder., [RefSeq, PubMed]; PLXNB1 mutations in the etiology of idiopathic hypogonadotropic hypogonadism., [RefSeq, PubMed]; PLXNB1/SEMA4D signals mediate interactions between malignant epithelial and immune cells to promote colorectal cancer liver metastasis., [RefSeq, PubMed]; Receptor for SEMA4D (PubMed:19843518, PubMed:20877282, PubMed:21912513). Plays a role in GABAergic synapse development (By similarity). Mediates SEMA4A- and SEMA4D-dependent inhibitory synapse development (By similarity). Plays a role in RHOA activation and subsequent changes of the actin cytoskeleton (PubMed:12196628, PubMed:15210733). Plays a role in axon guidance, invasive growth and cell migration (PubMed:12198496)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Semaphorin4A promotes lung cancer by activation of NF-kappaB pathway mediated by PlexinB1. Publication Status: Online-Only, [RefSeq, PubMed]; The plexin-B1/Rac interaction inhibits PAK activation and enhances Sema4D ligand binding, [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 9,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 58,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 29,
        "disease_count": 2,
        "glyco_site_count": 17,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8Y2;Q6NY20;Q9UIV7;Q9UJ92;Q9UJ93",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0005096 GTPase activator activity;GO:0030215 semaphorin receptor binding;GO:0032794 GTPase activating protein binding;GO:0017154 semaphorin receptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0002116 semaphorin receptor complex;GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0045211 postsynaptic membrane",
        "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0007162 negative regulation of cell adhesion;GO:0016477 cell migration;GO:0035556 intracellular signal transduction;GO:0043547 positive regulation of GTPase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 15.4,
        "record_id": "O43157-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IY26-1",
        "uniprot_id": [
            {
                "id": "PLPP6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IY26",
                "type": "external"
            }
        ],
        "mass": 32194.0,
        "length": 295,
        "protein_name": "Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6",
        "gene_name": "PLPP6",
        "organism": "Human",
        "refseq_name": "polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6",
        "refseq_ac": [
            {
                "id": "NP_982278",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_982278",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLPP6; PDP1; PPAPDC2",
        "gene_names_refseq": "LPRP-B; PA-PSP; PDP1; PLPP6; PPAPDC2; PSDP; bA6J24.6",
        "protein_names_uniprotkb": "Polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6; 3.1.3.-; 3.6.1.-; 3.6.1.68; LPRP-B; Lipid phosphatase-related protein-B; PA-PSP; PPAP2 domain-containing protein 2; Phosphatidic acid phosphatase type 2 domain-containing protein 2; Phospholipid phosphatase 6; Presqualene diphosphate phosphatase; Type 1 polyisoprenoid diphosphate phosphatase",
        "protein_names_refseq": "PPAP2 domain-containing protein 2; lipid phosphatase-related protein-B; phosphatidic acid phosphatase type 2 domain containing 2; phosphatidic acid phosphatase type 2 domain-containing protein 2; polyisoprenoid diphosphate phosphatase type 1; polyisoprenoid diphosphate/phosphate phosphohydrolase PLPP6; presqualene diphosphate phosphatase; type 1 polyisoprenoid diphosphate phosphatase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:403313);  (R-HSA-9969896)",
        "pathway_count": 2,
        "publication_count": 34,
        "publication_id_list": "10026212;10620343;10666321;10896663;11160603;1377680;14729858;14730012;14766201;16464866;16519518;16684881;17081983;18327899;18930839;18937434;19220020;20110354;20394422;21420384;23568778;24275569;26811146;30429286;32387766;33246356;35051231;5918048;7911016;7913309;8593458;8806705;9380443;9741684",
        "class_list": "",
        "function": "Data indicate that polyisoprenyl diphosphate phosphatase 1 (PDP1) serves an integral signaling role in neutrophil proinflammatory responses and as a target for counter-regulatory mediators., [RefSeq, PubMed]; Findings indicate that PPAPDC2 in human PMN is the first lipid phosphate phosphohydrolase identified for PSDP; regulation of this activity of the enzyme may have important roles for PMN activation in innate immunity, [RefSeq, PubMed]; Magnesium-independent polyisoprenoid diphosphatase that catalyzes the sequential dephosphorylation of presqualene, farnesyl, geranyl and geranylgeranyl diphosphates (PubMed:16464866, PubMed:19220020, PubMed:20110354). Functions in the innate immune response through the dephosphorylation of presqualene diphosphate which acts as a potent inhibitor of the signaling pathways contributing to polymorphonuclear neutrophils activation (PubMed:16464866, PubMed:23568778). May regulate the biosynthesis of cholesterol and related sterols by dephosphorylating presqualene and farnesyl diphosphate, two key intermediates in this biosynthetic pathway (PubMed:20110354). May also play a role in protein prenylation by acting on farnesyl diphosphate and its derivative geranylgeranyl diphosphate, two precursors for the addition of isoprenoid anchors to membrane proteins (PubMed:20110354). Has a lower activity towards phosphatidic acid (PA), but through phosphatidic acid dephosphorylation may participate in the biosynthesis of phospholipids and triacylglycerols (PubMed:18930839). May also act on ceramide-1-P, lysophosphatidic acid (LPA) and sphing-4-enine 1-phosphate/sphingosine-1-phosphate (PubMed:18930839, PubMed:20110354)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; PDP1 can serve as a new checkpoint for polyisoprenyl phosphate remodeling during cell activation.[PDP1], [RefSeq, PubMed]; PDP1/PPAPDC2 is a functional isoprenoid diphosphate phosphatase., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KY05;Q5JVJ6;Q8NCK9",
        "ec_number_list": [
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4",
                "type": "external"
            },
            {
                "id": "3.1.3.106",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106",
                "type": "external"
            },
            {
                "id": "3.6.1.75",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75",
                "type": "external"
            },
            {
                "id": "3.6.1.58",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.58",
                "type": "external"
            },
            {
                "id": "3.6.1.68",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68",
                "type": "external"
            },
            {
                "id": "3.6.1.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.76",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0016787 hydrolase activity;GO:0016829 lyase activity;GO:0008195 phosphatidate phosphatase activity;GO:0042577 lipid phosphatase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane",
        "go_biological_process": "GO:0045087 innate immune response;GO:0006695 cholesterol biosynthetic process;GO:0042632 cholesterol homeostasis;GO:0006720 isoprenoid metabolic process;GO:0018342 protein prenylation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q8IY26-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UQE7-1",
        "uniprot_id": [
            {
                "id": "SMC3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UQE7",
                "type": "external"
            }
        ],
        "mass": 141542.0,
        "length": 1217,
        "protein_name": "Structural maintenance of chromosomes protein 3",
        "gene_name": "SMC3",
        "organism": "Human",
        "refseq_name": "structural maintenance of chromosomes protein 3",
        "refseq_ac": [
            {
                "id": "NP_005436",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005436",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SMC3; BAM; BMH; CSPG6; SMC3L1",
        "gene_names_refseq": "BAM; BMH; CDLS3; CSPG6; HCAP; SMC3L1; SMC3",
        "protein_names_uniprotkb": "Structural maintenance of chromosomes protein 3; Bamacan; Basement membrane-associated chondroitin proteoglycan; Chondroitin sulfate proteoglycan 6; Chromosome-associated polypeptide; SMC protein 3; SMC-3; hCAP",
        "protein_names_refseq": "SMC protein 3; basement membrane-associated chondroitin proteoglycan; chondroitin sulfate proteoglycan 6 (bamacan); chromosome-associated polypeptide; structural maintenance of chromosomes protein 3",
        "tax_id": 9606,
        "disease": "Cornelia de Lange syndrome 3 (Disease Ontology:DOID:0080507); intellectual disability (Disease Ontology:DOID:1059); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:9126);  (R-HSA-1221632);  (R-HSA-2467813);  (R-HSA-2468052);  (R-HSA-2470946);  (R-HSA-2500257);  (R-HSA-3108214);  (R-HSA-9018519)",
        "pathway_count": 8,
        "publication_count": 350,
        "publication_id_list": "10411507;10500157;10574707;10828826;10873660;11010967;11034064;11076961;11081627;11103799;11136970;11165043;11345900;11371342;11410592;11452016;11509732;11581164;11590136;11673449;11682626;11792325;11889051;12194817;12198550;12498683;12612073;12959972;14631847;14675539;14730319;15001666;15125634;15175327;15235794;15276198;15282324;15302935;15339662;15343269;15345050;15355988;15514030;15608651;15656913;15723797;15737063;15821733;15823533;15829507;15837422;15940266;15958495;15959518;15986123;16009131;16030353;16046058;16087863;16113099;1630819;16478998;16541025;16608850;16626738;16682347;16688858;16810316;16980581;17013392;17105772;17112726;17113138;17273969;17277772;17463000;17495528;17510434;17525332;17637753;17666587;17690249;17693435;18077418;18097444;18187655;18219272;18256232;18322535;18358809;18411254;18442975;18452278;18476782;18533032;18614053;18625722;18669648;18691969;18691976;18708356;18716626;18762174;18805503;18996922;19001364;19020303;19098913;19146767;19274700;19287951;19295514;19321454;19367720;19383337;19596686;19608861;19622798;19629043;19696148;19706679;19718048;19748539;19779455;19907496;19956565;19965387;20016594;20016603;20068231;20190268;20219941;20220130;20498280;20501661;20570965;20634189;20682797;20705237;21098080;21106759;21111234;21147198;21151129;21284855;21406692;21445275;21550342;21573489;2181374;21835891;21878504;21878914;21934649;21940756;21987589;22056668;22101327;22265404;22346761;22424782;22492511;22508508;22544926;22545144;22628566;22635276;22661230;22704330;22751501;22885700;22898188;23145106;23172872;23186163;23192763;23303788;23403292;23435229;23481700;23723241;23750026;23871147;23906331;24027577;24167369;24275569;24366607;24371278;24714562;24715725;24735615;24782567;24854081;24885040;24973012;24998469;25114211;25125236;25218447;25296600;25365482;25418920;25433557;25542856;25576301;25633194;25645385;25655089;25663755;25674852;25728767;25802875;25810538;25892735;26056233;26153859;26154972;26204489;26375851;26462610;26479350;26728094;26758079;26811146;26992070;27062924;27397612;27600516;27846572;27862975;27886276;27920218;28063628;28218747;28228285;28510447;28539435;28649982;28832583;28834231;28860189;28904123;2919170;29242379;29314611;29331515;29351928;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30410026;30429286;3045126;30484775;30524438;30779550;31092671;31154438;31217245;31334757;31452512;31530632;31844290;31848261;32157095;32265295;32350084;32357974;32387766;32409525;32488085;32502341;3281094;32897882;32938616;32983136;33123756;33141586;33214551;33298915;33392160;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34229054;34260926;34405274;34509645;34561969;34725712;34932366;3498214;35051231;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;3677090;37641131;37938771;38017479;38297832;40307207;40596516;40914422;7559524;7935485;7937828;8195246;8197458;8291532;8419924;8794855;8876171;9008167;9201922;9285814;9338790;9388265;9412458;9452416;9506951;9611253;9649503;9671459;9731700;9756909;9885291;9892021",
        "class_list": "glycogene",
        "function": "Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement., [UniProtKB, PubMed, PubMed]; Heterozygous loss-of-function SMC3 variants are associated with variable growth and developmental features., [RefSeq, PubMed]; RIT1 regulates mitosis and promotes proliferation by interacting with SMC3 and PDS5 in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; This gene belongs to the SMC3 subfamily of SMC proteins. The encoded protein occurs in certain cell types as either an intracellular, nuclear protein or a secreted protein. The nuclear form, known as structural maintenance of chromosomes 3, is a component of the multimeric cohesin complex that holds together sister chromatids during mitosis, enabling proper chromosome segregation. Post-translational modification of the encoded protein by the addition of chondroitin sulfate chains gives rise to the secreted proteoglycan bamacan, an abundant basement membrane protein. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 903,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K156;O60464;Q5T482",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0046982 protein heterodimerization activity;GO:0016887 ATP hydrolysis activity;GO:0003690 double-stranded DNA binding",
        "go_cellular_component": "GO:0030892 mitotic cohesin complex;GO:0030893 meiotic cohesin complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006281 DNA repair;GO:0051301 cell division;GO:0090307 mitotic spindle assembly;GO:0006275 regulation of DNA replication",
        "synthesized_glycan_count": 0,
        "hit_score": 35.5,
        "record_id": "Q9UQE7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P48764-1",
        "uniprot_id": [
            {
                "id": "SL9A3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P48764",
                "type": "external"
            }
        ],
        "mass": 92855.0,
        "length": 834,
        "protein_name": "Sodium/hydrogen exchanger 3",
        "gene_name": "SLC9A3",
        "organism": "Human",
        "refseq_name": "sodium/hydrogen exchanger 3 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001271280",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001271280",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC9A3; NHE3",
        "gene_names_refseq": "DIAR8; NHE-3; NHE3; SLC9A3",
        "protein_names_uniprotkb": "Sodium/hydrogen exchanger 3; NHE-3; Na(+)/H(+) exchanger 3; Solute carrier family 9 member 3",
        "protein_names_refseq": "Na(+)/H(+) exchanger 3; sodium/hydrogen exchanger 3 isoform 2 precursor; solute carrier family 9 (sodium/hydrogen exchanger), member 3; solute carrier family 9, subfamily A (NHE3, cation proton antiporter 3), member 3",
        "tax_id": 9606,
        "disease": "sleep apnea (Disease Ontology:DOID:0050847); left ventricular failure (Disease Ontology:DOID:0051064); congenital secretory sodium diarrhea 8 (Disease Ontology:DOID:0060777); hypertension (Disease Ontology:DOID:10763); exocrine pancreatic insufficiency (Disease Ontology:DOID:13316); malignant renovascular hypertension (Disease Ontology:DOID:13730); cystic fibrosis (Disease Ontology:DOID:1485); renovascular hypertension (Disease Ontology:DOID:1591); nephrolithiasis (Disease Ontology:DOID:585); gastrointestinal system disease (Disease Ontology:DOID:77); chronic kidney disease (Disease Ontology:DOID:784); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:6550);  (R-HSA-425986)",
        "pathway_count": 2,
        "publication_count": 33,
        "publication_id_list": "10444453;11237011;11279194;11940519;15522866;15888551;18829453;19088451;20584908;24622516;2536298;25851603;25855080;26358773;27862975;29557506;30484775;31154438;31276831;32387766;32488085;32502341;32938616;34509645;35051231;35580925;35613257;36189974;38047302;38091065;38448727;7631746;9933641",
        "class_list": "",
        "function": "Downregulation of NHE-3 (SLC9A3) expression by MicroRNAs in intestinal epithelial cells., [RefSeq, PubMed]; New functions and roles of the Na[+]-H[+]-exchanger NHE3. Review article, [RefSeq, PubMed]; Plasma membrane Na(+)/H(+) antiporter (PubMed:18829453, PubMed:26358773, PubMed:35613257). Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis (By similarity). Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation (PubMed:24622516, PubMed:26358773)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Plasma membrane Na(+)/H(+) antiporter. Exchanges intracellular H(+) ions for extracellular Na(+) in 1:1 stoichiometry, playing a key role in salt and fluid absorption and pH homeostasis. Major apical Na(+)/H(+) exchanger in kidney and intestine playing an important role in renal and intestine Na(+) absorption and blood pressure regulation., [UniProtKB, UniProtKB]; Regulation of the intestinal Na[+]/H[+] exchanger NHE3 by AMP-activated kinase is dependent on phosphorylation of NHE3 at S555 and S563., [RefSeq, PubMed]; Revisiting the association of sudden infant death syndrome (SIDS) with polymorphisms of NHE3 and IL13., [RefSeq, PubMed]; The protein encoded by this gene is an epithelial brush border Na/H exchanger that uses an inward sodium ion gradient to expel acids from the cell. Defects in this gene are a cause of congenital secretory sodium diarrhea. Pseudogenes of this gene exist on chromosomes 10 and 22. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 12,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZKR2;E9PF67;Q3MIW3",
        "ec_number_list": [
            {
                "id": "1.1.1.30",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.30",
                "type": "external"
            },
            {
                "id": "1.1.1.104",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.104",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0015385 sodium:proton antiporter activity;GO:0015386 potassium:proton antiporter activity;GO:0042802 identical protein binding;GO:0030165 PDZ domain binding;GO:0035091 phosphatidylinositol binding",
        "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005903 brush border;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane",
        "go_biological_process": "GO:0006883 intracellular sodium ion homeostasis;GO:0035725 sodium ion transmembrane transport;GO:0051453 regulation of intracellular pH;GO:0071805 potassium ion transmembrane transport;GO:0098719 sodium ion import across plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "P48764-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75159-1",
        "uniprot_id": [
            {
                "id": "SOCS5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75159",
                "type": "external"
            }
        ],
        "mass": 61246.0,
        "length": 536,
        "protein_name": "Suppressor of cytokine signaling 5",
        "gene_name": "SOCS5",
        "organism": "Human",
        "refseq_name": "suppressor of cytokine signaling 5",
        "refseq_ac": [
            {
                "id": "NP_054730",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054730",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SOCS5; CIS6; CISH5; CISH6; KIAA0671",
        "gene_names_refseq": "CIS6; CISH6; Cish5; SOCS-5; SOCS5",
        "protein_names_uniprotkb": "Suppressor of cytokine signaling 5; CIS-6; Cytokine-inducible SH2 protein 6; Cytokine-inducible SH2-containing protein 5; SOCS-5",
        "protein_names_refseq": "CIS-6; cytokine-inducible SH2 protein 6; cytokine-inducible SH2-containing protein 5; suppressor of cytokine signaling 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9655);  (R-HSA-6785807);  (R-HSA-8951664)",
        "pathway_count": 3,
        "publication_count": 239,
        "publication_id_list": "10023775;10219247;10369418;10510379;10535940;10586089;10597293;10773671;10811609;10867011;10878807;10973499;11058569;11069780;11084045;11104795;11120780;11230166;11237011;11259415;11278437;11278729;11292861;11292862;11356008;11404481;11454738;11463377;11585840;11733065;11960372;11961546;12101228;12186903;12223527;12242343;12504025;12504026;12526791;12538644;12600988;12609982;12682069;12759363;12816948;12832402;14634100;14690597;14712222;14757770;15116091;15261459;15282312;15361859;15367669;15537541;15572695;15574592;15584925;15590694;15601839;15652483;15688063;15694336;15799966;15805299;15869882;15950906;16007214;16048438;16107692;16171779;16205632;16236134;16397018;16401342;16451196;16510571;16540365;16547496;16606674;16647857;16707496;16790436;16943200;17081101;17132228;17183367;17220875;17332328;17427945;17458857;17497243;17572495;17785452;18093314;18206966;18243101;18353781;18447642;18644974;18775313;18776931;18805092;18826954;18851830;18926707;19124156;19185846;19250909;19321346;19397496;19617556;19748355;20493732;21102457;21252155;21447816;21463634;21689689;21730069;21778237;21863050;21937440;21940857;21994466;22046235;22205702;22306028;22383755;22466964;22537386;22693070;22851691;22959436;23086340;23124025;23172665;23201271;23333871;23401859;23453757;23455323;23481700;23535662;23535663;23555662;23563313;23583660;23912815;23967200;23986495;24076655;24097101;24366543;24636985;24715725;24743777;24793695;24793696;25234944;25314029;25349211;25355947;25531226;25576301;25892735;26024233;26154972;26344709;26460955;26632597;26906416;26992070;27030794;27222660;27397612;27565346;27846572;28115426;28218747;28228285;28514659;28834231;29153394;29242379;29437277;29493099;29557506;29632711;29769354;29786170;30315122;30410026;30429286;30610225;31530632;31844290;31848261;31937595;32005965;32157095;32284348;32983136;33298915;33444648;33592498;34932366;35051231;35121374;35318648;35580925;37646261;37672963;37828534;37938771;7510216;7512451;7529288;7795521;7796300;7898939;7907877;8085155;8602263;8621622;8663118;8668165;8797861;8816495;9013879;9651359;9723655;9736340;9790970;9822675;9874564;9887101;9891082",
        "class_list": "",
        "function": "Evaluation of SOCS5 mRNA and its association with serum IL-12 levels and rs41379147 SNP in various subsets of allergic disorders: A case control study., [RefSeq, PubMed]; Inhibition of microRNA-448 suppresses CD4(+) T cell inflammatory activation via up-regulating suppressor of cytokine signaling 5 in systemic lupus erythematosus., [RefSeq, PubMed]; Resistin stimulates PC-3 prostate cancer cell growth through stimulation of SOCS3 and SOCS5 genes., [RefSeq, PubMed]; SOCS family proteins form part of a classical negative feedback system that regulates cytokine signal transduction. May be a substrate-recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Inhibits for instance EGF signaling by mediating the degradation of the EGF receptor/EGFR. Involved in the regulation of T-helper cell differentiation by inhibiting of the IL4 signaling pathway which promotes differentiation into the Th2 phenotype. Can also partially inhibit IL6 and LIF signaling., [UniProtKB, PubMed]; Sequential inspiratory muscle exercise-noninvasive positive pressure ventilation alleviates oxidative stress in COPD by mediating SOCS5/JAK2/STAT3 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "reported_mutagensis": 3,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53SD4;Q8IYZ4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0030971 receptor tyrosine kinase binding",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0032715 negative regulation of interleukin-6 production;GO:0050728 negative regulation of inflammatory response;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 24.0,
        "record_id": "O75159-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43543-1",
        "uniprot_id": [
            {
                "id": "XRCC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43543",
                "type": "external"
            }
        ],
        "mass": 31956.0,
        "length": 280,
        "protein_name": "DNA repair protein XRCC2",
        "gene_name": "XRCC2",
        "organism": "Human",
        "refseq_name": "DNA repair protein XRCC2",
        "refseq_ac": [
            {
                "id": "NP_005422",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005422",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "XRCC2",
        "gene_names_refseq": "FANCU; POF17; SPGF50; XRCC2",
        "protein_names_uniprotkb": "DNA repair protein XRCC2; X-ray repair cross-complementing protein 2",
        "protein_names_refseq": "DNA repair protein XRCC2; X-ray repair complementing defective repair in Chinese hamster cells 2; X-ray repair cross-complementing protein 2; epididymis secretory sperm binding protein",
        "tax_id": 9606,
        "disease": "primary ovarian insufficiency 17 (Disease Ontology:DOID:0080874); Fanconi anemia complementation group U (Disease Ontology:DOID:0111085); spermatogenic failure 50 (Disease Ontology:DOID:0112272); pancreatic cancer (Disease Ontology:DOID:1793)",
        "pathway": " (hsa:7516);  (R-HSA-5685942);  (R-HSA-5693537);  (R-HSA-5693554);  (R-HSA-5693568);  (R-HSA-5693579);  (R-HSA-5693616);  (R-HSA-9701192);  (R-HSA-9704331);  (R-HSA-9704646);  (R-HSA-9709603)",
        "pathway_count": 11,
        "publication_count": 138,
        "publication_id_list": "10373512;10570174;10733923;10801132;10856253;11006276;11237011;11459987;11744692;11751635;11832208;11834724;11842112;11842113;12023985;12228710;12686547;12721304;12912992;14527420;14578164;14704354;14716019;15359272;15665856;15703751;15916957;15924337;16195237;16337601;16793542;17114795;17200668;17200671;17200672;17289582;17420451;17525332;17557904;17986315;17996710;17996711;18317453;18957201;19064565;19074197;19268590;19369211;19584259;19596236;19609323;19690184;19941829;20127279;20207730;20729832;20729858;20729859;20871615;20871616;20965415;21104022;21276791;21290343;21520333;21701125;22194698;22232082;22464251;22487057;22593209;22611952;22645308;23054243;23149936;23186163;23509288;23539294;23686288;23731732;23754376;23810717;24013206;24076221;24141787;24371268;24377596;24485656;24509834;24714562;24728564;24831703;25556451;25576301;26145171;26629080;26728094;26801223;26893845;26992070;27233470;27600516;27899578;28089683;28158555;28228285;28240985;28319063;28834231;29165669;29242379;29608566;30042186;30237576;30289697;30311374;30489636;30566856;31586400;31636395;31757951;31844290;32157095;32502341;32732220;33195396;33592498;33978741;33981976;34440403;35580925;37344589;37522793;37774058;38285766;9126486;9628903;9660962",
        "class_list": "",
        "function": "Association between XRCC2 Arg188His Polymorphism and Breast Cancer Susceptibility: A Systematic Review and Meta-Analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Association of RAD51, XRCC1, XRCC2, and XRCC3 Polymorphisms with Risk of Breast Cancer., [RefSeq, PubMed]; Impact of Interaction between Single Nucleotide Polymorphism of XRCC1, XRCC2, XRCC3 with Tumor Suppressor Tp53 Gene Increases Risk of Breast Cancer: A Hospital Based Case-Control Study. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions. Part of the RAD51 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Structural insights into BCDX2 complex function in homologous recombination. Erratum:[Nature. 2026 Jan;649(8098):E12. doi: 10.1038/s41586-025-10081-3. PMID: 41507367], [RefSeq, PubMed]; This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
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        "reported_phosphosites": 3,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "B2R925",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0140664 ATP-dependent DNA damage sensor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005813 centrosome;GO:0005657 replication fork;GO:0033063 Rad51B-Rad51C-Rad51D-XRCC2 complex",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006281 DNA repair;GO:0000724 double-strand break repair via homologous recombination;GO:0007098 centrosome cycle;GO:0051321 meiotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 13.9,
        "record_id": "O43543-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5VYJ5-1",
        "uniprot_id": [
            {
                "id": "MALR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5VYJ5",
                "type": "external"
            }
        ],
        "mass": 241008.0,
        "length": 2156,
        "protein_name": "MAM and LDL-receptor class A domain-containing protein 1",
        "gene_name": "MALRD1",
        "organism": "Human",
        "refseq_name": "MAM and LDL-receptor class A domain-containing protein 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001135780",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135780",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MALRD1; C10orf112; DIET1",
        "gene_names_refseq": "C10orf112; DIET1; MALRD1; bA265G8.2",
        "protein_names_uniprotkb": "MAM and LDL-receptor class A domain-containing protein 1",
        "protein_names_refseq": "MAM and LDL-receptor class A domain-containing protein 1 precursor; MAM and LDL-receptor class A domain-containing protein 1; MAM and LDL-receptor class A domain-containing protein C10orf112; novel MAM domain containing protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:340895)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;19103277;19591129;23747249;26045262;27600516;29242379;29557506;31694064;32488085;33141586;35051231;35580925;37217939",
        "class_list": "",
        "function": "Clinical variability and probable founder effect in oculocutaneous albinism type 7., [RefSeq, PubMed]; Diet1 appears to be a control point for the production of fibroblast growth factor 15/19 in enterocytes, and thus a regulator of bile acid and lipid homeostasis., [RefSeq, PubMed]; Enhances production and/or transport of FGF19 and thus has a role in regulation of bile acid synthesis., [UniProtKB, PubMed]; Expression of these C10orf112 mRNA species was limited to a subset of brain regions and heart tissue, [RefSeq, PubMed]; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a conserved protein that features multiple MAM (meprin-A5-protein tyrosine phosphatase mu) and LDLR A2 (low density lipoprotein receptor A2) domains. Expression of this gene is enriched in the small intestine and is upregulated during differentiation of a human cell line that exhibits properties of intestinal epithelial cells. The encoded protein has been shown to modulate production of FGF19 in a human intestinal cell line and may regulate bile acid metabolism in the liver. A synergistic interaction between an allele of this gene and the APOE E4 allele is associated with an elevated risk of Alzheimer's disease in human patients. [provided by RefSeq, Jul 2017]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 2,
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        "total_reported_n_glycosites": 1,
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        "secondary_ac_list": "B7ZBP2;R9WAE9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0030659 cytoplasmic vesicle membrane;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q5VYJ5-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43325-1",
        "uniprot_id": [
            {
                "id": "LYRM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43325",
                "type": "external"
            }
        ],
        "mass": 14282.0,
        "length": 122,
        "protein_name": "LYR motif-containing protein 1",
        "gene_name": "LYRM1",
        "organism": "Human",
        "refseq_name": "LYR motif-containing protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001121773",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001121773",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LYRM1",
        "gene_names_refseq": "A211C6.1; LYRM1",
        "protein_names_uniprotkb": "LYR motif-containing protein 1",
        "protein_names_refseq": "LYR motif-containing protein 1 isoform 1; LYR motif-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57149)",
        "pathway_count": 1,
        "publication_count": 54,
        "publication_id_list": "11237011;18446792;19022914;20826099;20877624;20938407;22820890;23481700;24714562;24715725;25418920;25576301;25645385;26154972;26375851;26929215;27920218;28218747;28228285;28514659;28832583;29242379;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30315122;31092671;31154438;31844290;31848261;31998317;32157095;32161166;32265295;32357974;32387766;32502341;32897882;32983136;33298915;33691108;33912179;33936100;34171305;34211107;34357683;34932366;35051231;35580925;36284347",
        "class_list": "",
        "function": "Alpha-LA protects 3T3-L1 adipocytes from LYRM1-induced insulin resistance partially via its capacity to restore mitochondrial function and/or increase phosphorylation of IRS-1 and Akt., [RefSeq, PubMed]; By increasing cell proliferation and lowering the rate of apoptosis, LYRM1 has the potential to modulate the size of the preadipocyte pool and influence adipose tissue homeostasis, [RefSeq, PubMed]; Data suggest that LYRM1 might have the potential to modulate cell growth, apoptosis, and heart development. Publication Status: Online-Only, [RefSeq, PubMed]; May promote cell proliferation and inhibition of apoptosis of preadipocytes., [UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Overexpression of LYRM1 caused mitochondrial dysfunction in adipocytes, which might be responsible for the development of LYRM1-induced insulin resistance, [RefSeq, PubMed]; The protein encoded by this gene belongs to the mitochondrial leucine/tyrosine/arginine motif family of proteins. Proteins of this family are short polypeptides that contain a leucine/tyrosine/arginine motif near the N-terminus. This gene is widely expressed with high levels in omental adipose tissue of obese individuals. In adipose tissue, the protein is localized to the nucleus where it promotes preadipocyte proliferation and lowers the rate of apoptosis to regulate adipose tissue homeostasis. Overexpression of this gene in adipocytes causes abnormal mitochondrial morphology and mitochondrial dysfunction. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]., [RefSeq]",
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "B2R4M5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005739 mitochondrion",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "O43325-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "MAJIN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q3KP22",
                "type": "external"
            }
        ],
        "mass": 20078.0,
        "length": 176,
        "protein_name": "Membrane-anchored junction protein",
        "gene_name": "MAJIN",
        "organism": "Human",
        "refseq_name": "membrane-anchored junction protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001032302",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001032302",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAJIN; C11orf85",
        "gene_names_refseq": "C11orf85; MAJIN",
        "protein_names_uniprotkb": "Membrane-anchored junction protein",
        "protein_names_refseq": "membrane-anchored junction protein isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283129)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;30410026;30559341;30718482;33912179",
        "class_list": "",
        "function": "Complementary structured illumination microscopy studies and biochemical findings reveal a telomere attachment mechanism in which MAJIN-TERB2-TERB1 recruits telomere-bound TRF1, which is then displaced during pachytene, allowing MAJIN-TERB2-TERB1 to bind telomeric DNA and form a mature attachment plate. Publication Status: Online-Only, [RefSeq, PubMed]; Meiosis-specific telomere-associated protein involved in meiotic telomere attachment to the nucleus inner membrane, a crucial step for homologous pairing and synapsis. Component of the MAJIN-TERB1-TERB2 complex, which promotes telomere cap exchange by mediating attachment of telomeric DNA to the inner nuclear membrane and replacement of the protective cap of telomeric chromosomes: in early meiosis, the MAJIN-TERB1-TERB2 complex associates with telomeric DNA and the shelterin/telosome complex. During prophase, the complex matures and promotes release of the shelterin/telosome complex from telomeric DNA. In the complex, MAJIN acts as the anchoring subunit to the nucleus inner membrane. MAJIN shows DNA-binding activity, possibly for the stabilization of telomere attachment on the nucleus inner membrane., [UniProtKB, UniProtKB]; The meiotic TERB1-TERB2-MAJIN complex tethers telomeres to the nuclear envelope Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KS99;E9PPE5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding",
        "go_cellular_component": "GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane;GO:0000781 chromosome, telomeric region",
        "go_biological_process": "GO:0090435 protein localization to nuclear envelope;GO:0070197 meiotic attachment of telomere to nuclear envelope;GO:0007129 homologous chromosome pairing at meiosis;GO:0045141 meiotic telomere clustering",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q3KP22-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y2E5-1",
        "uniprot_id": [
            {
                "id": "MA2B2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y2E5",
                "type": "external"
            }
        ],
        "mass": 113979.0,
        "length": 1009,
        "protein_name": "Epididymis-specific alpha-mannosidase",
        "gene_name": "MAN2B2",
        "organism": "Human",
        "refseq_name": "epididymis-specific alpha-mannosidase isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001278967",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278967",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAN2B2; KIAA0935",
        "gene_names_refseq": "CDG1EE; EpMAN; MAN2B2",
        "protein_names_uniprotkb": "Epididymis-specific alpha-mannosidase; 3.2.1.24; Alpha-1,6-mannosidase; Core-specific lysosomal alpha-1,6-Mannosidase; Epman; Mannosidase alpha class 2B member 2",
        "protein_names_refseq": "alpha-1,6-mannosidase; core-specific lysosomal alpha-1,6-Mannosidase; epididymis secretory sperm binding protein; epididymis-specific alpha-mannosidase isoform 2 precursor; epididymis-specific alpha-mannosidase",
        "tax_id": 9606,
        "disease": "congenital disorder of glycosylation type 1EE with or without immunodeficiency (MONDO:MONDO:0976261)",
        "pathway": " (hsa:23324);  (R-HSA-8853383)",
        "pathway_count": 2,
        "publication_count": 84,
        "publication_id_list": "10.1101/2023.09.13.557529;10513892;11237011;11350179;1576208;1577805;16115860;16848760;17420068;19159218;19722277;20800603;23090970;23481700;24190977;24715725;25345101;25645385;25762455;25880248;25892735;26853435;26992070;27600516;27846572;28218747;28228285;28467828;28832583;28904123;29242379;29314611;29317506;29391424;29437277;29557506;29632046;29741879;29786170;30315122;30410026;30429286;30459171;30573663;31020640;31154438;31775018;31844290;31848261;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33592498;33717175;33912179;33968037;33981976;34171305;34185709;34357683;34433824;34509645;34561969;35051231;35154160;35251023;35580925;35637269;36010968;36215666;36241641;36284347;37074911;38622837;38665916;8910458;9384606",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "Expressed MAN2B1 and MAN2B2 in Drosophila S2 cells and functionally characterized them. MAN2B1 and MAN2B2 were significantly inhibited by the class II alpha-mannosidase inhibitors, swainsonine and mannostatin A., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Specifically cleaves terminal alpha 1,6-linked mannose residues on Man3GlcNAc and Man2GlcNAc core oligosaccharides generated by N-glycan degradation pathways, having little activity, if any, on larger mannose oligosaccharides (PubMed:1577805, PubMed:16115860). Does not cleave terminal alpha 1,6-linked mannose on Man3GlcNAc2, and is also unable to hydrolyze terminal alpha 1,3-mannose linkages (PubMed:1577805, PubMed:16115860)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 7,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 7,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1430,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 28,
        "disease_count": 1,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q66MP2;Q86T67",
        "ec_number_list": [
            {
                "id": "3.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.24",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity;GO:0008496 mannan endo-1,6-alpha-mannosidase activity;GO:0052767 mannosyl-oligosaccharide 1,6-alpha-mannosidase activity",
        "go_cellular_component": "GO:0070062 extracellular exosome;GO:0005764 lysosome;GO:0043202 lysosomal lumen;GO:0005576 extracellular region",
        "go_biological_process": "GO:0006013 mannose metabolic process;GO:0009313 oligosaccharide catabolic process;GO:0006516 glycoprotein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "Q9Y2E5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000011000.101.10100",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P16581-1",
        "uniprot_id": [
            {
                "id": "LYAM2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P16581",
                "type": "external"
            }
        ],
        "mass": 66655.0,
        "length": 610,
        "protein_name": "E-selectin",
        "gene_name": "SELE",
        "organism": "Human",
        "refseq_name": "E-selectin precursor",
        "refseq_ac": [
            {
                "id": "NP_000441",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000441",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SELE; ELAM1",
        "gene_names_refseq": "CD62E; ELAM1; ELAM; ESEL; LECAM2; SELE; selectin-e",
        "protein_names_uniprotkb": "E-selectin; CD62 antigen-like family member E; ELAM-1; Endothelial leukocyte adhesion molecule 1; LECAM2; Leukocyte-endothelial cell adhesion molecule 2",
        "protein_names_refseq": "CD62 antigen-like family member E; E-selectin precursor; E-selectin; ELAM-1; endothelial adhesion molecule 1; endothelial leukocyte adhesion molecule 1; leukocyte endothelial cell adhesion molecule 2",
        "tax_id": 9606,
        "disease": "COVID-19 (Disease Ontology:DOID:0080600); aortic atherosclerosis (Disease Ontology:DOID:10230); brain ischemia (Disease Ontology:DOID:2316); IgA glomerulonephritis (Disease Ontology:DOID:2986); coronary artery disease (Disease Ontology:DOID:3393); cerebrovascular disease (Disease Ontology:DOID:6713); rheumatic myocarditis (Disease Ontology:DOID:8481); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:6401);  (R-HSA-202733)",
        "pathway_count": 2,
        "publication_count": 100,
        "publication_id_list": "10391210;10606205;10764623;10982036;11081633;11207550;11237011;11256994;11564780;11602579;11779189;11812992;12070135;12208882;12469115;12649084;12782713;1375831;14529530;14615387;15000751;15489334;15528364;15681301;15721307;1591491;16258728;16297198;16585556;16691243;16710414;16737840;16783819;1689848;1694218;1701274;1703529;17064312;17099249;17116209;17167768;17172599;17322099;17379836;17442946;17452516;17505016;17525755;17563375;17580308;17600130;17615384;17625065;18606703;19279206;21193412;21659548;23945545;24043627;2466335;24688092;24764293;2538457;25787250;26117840;26828984;26992070;28011641;31844290;32458111;32814053;32901486;32983136;33167483;33285544;34262131;35051231;35580925;38243063;38428409;38493006;38650162;39409189;468991;7509040;7521878;7533025;7681016;8163559;8166770;8314844;8557254;9052782;9169774;9242610;9295288;9382878;9693095;9763524;9933738",
        "class_list": "glycogene",
        "function": "Analysis of ICAM-1 rs3093030, VCAM-1 rs3783605, and E-Selectin rs1805193 Polymorphisms in African Women Living with HIV and Preeclampsia. Publication Status: Online-Only, [RefSeq, PubMed]; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; E-selectin is associated with stable angina and myocardial infarction in a sample of Kurdish population. Publication Status: Online-Only, [RefSeq, PubMed]; PDGFRalpha[+]ITGA11[+] fibroblasts foster early-stage cancer lymphovascular invasion and lymphatic metastasis via ITGA11-SELE interplay., [RefSeq, PubMed]; PSGL-1 decorated with sialyl Lewis[a/x] promotes high affinity binding of myeloma cells to P-selectin but is dispensable for E-selectin engagement. Publication Status: Online-Only, [RefSeq, PubMed]; Targeting hematologic malignancies by inhibiting E-selectin: A sweet spot for AML therapy? Review article, [RefSeq, PubMed]; The protein encoded by this gene is found in cytokine-stimulated endothelial cells and is thought to be responsible for the accumulation of blood leukocytes at sites of inflammation by mediating the adhesion of cells to the vascular lining. It exhibits structural features such as the presence of lectin- and EGF-like domains followed by short consensus repeat (SCR) domains that contain 6 conserved cysteine residues. These proteins are part of the selectin family of cell adhesion molecules. Adhesion molecules participate in the interaction between leukocytes and the endothelium and appear to be involved in the pathogenesis of atherosclerosis. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 7,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 910,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "prognostic",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RRD6;P16111",
        "ec_number_list": [],
        "go_molecular_function": "GO:0070492 oligosaccharide binding;GO:0004888 transmembrane signaling receptor activity;GO:0046872 metal ion binding;GO:0033691 sialic acid binding;GO:0043274 phospholipase binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0045121 membrane raft;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:1903238 positive regulation of leukocyte tethering or rolling;GO:0006954 inflammatory response;GO:0019722 calcium-mediated signaling;GO:0032496 response to lipopolysaccharide;GO:0034612 response to tumor necrosis factor",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "P16581-1",
        "record_type": "protein",
        "filter_code": "0001000.1100111.100000.000000000001000000.1000000010001.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N135-1",
        "uniprot_id": [
            {
                "id": "LGI4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N135",
                "type": "external"
            }
        ],
        "mass": 59141.0,
        "length": 537,
        "protein_name": "Leucine-rich repeat LGI family member 4",
        "gene_name": "LGI4",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat LGI family member 4 precursor",
        "refseq_ac": [
            {
                "id": "NP_644813",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_644813",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LGI4; LGIL3; PRO21485",
        "gene_names_refseq": "AMC1; AMCNMY; LGI4; LGIL3",
        "protein_names_uniprotkb": "Leucine-rich repeat LGI family member 4; LGI1-like protein 3; Leucine-rich glioma-inactivated protein 4",
        "protein_names_refseq": "LGI1-like protein 3; leucine-rich glioma-inactivated gene 4; leucine-rich glioma-inactivated protein 4; leucine-rich repeat LGI family member 4 precursor",
        "tax_id": 9606,
        "disease": "arthrogryposis multiplex congenita (Disease Ontology:DOID:0080954); arthrogryposis multiplex congenita-1 (Disease Ontology:DOID:0080978); childhood absence epilepsy (Disease Ontology:DOID:1825)",
        "pathway": " (hsa:163175);  (R-HSA-5682910)",
        "pathway_count": 2,
        "publication_count": 26,
        "publication_id_list": "11237011;12023020;12095917;12217514;12975309;14505228;16990550;17387609;18628660;18974846;19815358;20162351;20220021;20461023;21829378;24662834;24715725;25645385;25892735;28318499;29351928;29557506;32387766;34288120;35051231;36228153",
        "class_list": "",
        "function": "Characterizing the molecular etiology of arthrogryposis multiplex congenita in patients with LGI4 mutations., [RefSeq, PubMed]; Component of Schwann cell signaling pathway(s) that controls axon segregation and myelin formation (By similarity)., [UniProtKB, UniProtKB]; Has seven copies of the EPTP repeat, a unifying protein sequence motif of a heterogenous group of proteins linked to epileptic diseases. The EPTP repeat probably forms a beta-propeller structure. Review article, [RefSeq, PubMed]; In four unrelated multiplex families presenting with severe arthrogryposis multiplex congenital, identified biallelic loss-of-function mutations in LGI4; functional tests showed these germline mutations caused aberrant splicing of the endogenous LGI4 transcript and in a cell-based assay impaired the secretion of truncated LGI4 protein, [RefSeq, PubMed]; Intratumoral heterogeneity of ADAM23 promotes tumor growth and metastasis through LGI4 and nitric oxide signals., [RefSeq, PubMed]; Schwann cells are the principal cellular source of Lgi4 in the developing nerve; transgenic Lgi4 binds directly to Adam22 without a requirement for additional membrane associated factors., [RefSeq, PubMed]; Screening of the LGI4 coding region in BFIC and childhood absence epilepsy (CAE) revealed several frequent exonic polymorphisms. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The positive genotypic association between benign familial infantile convulsions (BFIC)and c.1722G/A polymorphism suggests that LGI4 might contribute to the susceptibility to BFIC. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RN53;B9EGS7;Q5M8T1",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0022011 myelination in peripheral nervous system;GO:0031641 regulation of myelination;GO:0042551 neuron maturation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q8N135-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9ULX9-1",
        "uniprot_id": [
            {
                "id": "MAFF_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9ULX9",
                "type": "external"
            }
        ],
        "mass": 17760.0,
        "length": 164,
        "protein_name": "Transcription factor MafF",
        "gene_name": "MAFF",
        "organism": "Human",
        "refseq_name": "transcription factor MafF isoform a",
        "refseq_ac": [
            {
                "id": "NP_001155044",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001155044",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAFF",
        "gene_names_refseq": "MAFF; U-MAF; hMafF",
        "protein_names_uniprotkb": "Transcription factor MafF; U-Maf; V-maf musculoaponeurotic fibrosarcoma oncogene homolog F",
        "protein_names_refseq": "transcription factor MAFF; transcription factor MafF isoform a; v-maf avian musculoaponeurotic fibrosarcoma oncogene family protein F; v-maf avian musculoaponeurotic fibrosarcoma oncogene homolog F",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23764);  (R-HSA-983231)",
        "pathway_count": 2,
        "publication_count": 59,
        "publication_id_list": "10527846;11042108;11062261;11237011;11242053;11744692;11751636;11772409;11895428;11950885;12032298;12134158;12427746;15020713;15247287;15710388;16054028;1630448;16549056;17027967;17196961;18477386;19293402;20068231;20530532;20627800;218813;23481700;25645385;26845023;27600516;28446606;28832583;28904123;29242379;29493099;31092671;31844290;32157095;32161166;32488085;32938616;32983136;33633747;33968037;33980595;34019948;3409321;34262028;37217939;8662638;8816476;8932385;9065479;9230307;9326583;9331217;9422515;9927674",
        "class_list": "",
        "function": "MafF Is an Antiviral Host Factor That Suppresses Transcription from Hepatitis B Virus Core Promoter., [RefSeq, PubMed]; Since they lack a putative transactivation domain, the small Mafs behave as transcriptional repressors when they dimerize among themselves (PubMed:8932385). However, they seem to serve as transcriptional activators by dimerizing with other (usually larger) basic-zipper proteins, such as NFE2L1/NRF1, and recruiting them to specific DNA-binding sites. Interacts with the upstream promoter region of the oxytocin receptor gene (PubMed:16549056, PubMed:8932385). May be a transcriptional enhancer in the up-regulation of the oxytocin receptor gene at parturition (PubMed:10527846)., [UniProtKB, PubMed, PubMed, PubMed]; The HIF target MAFF promotes tumor invasion and metastasis through IL11 and STAT3 signaling. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a basic leucine zipper (bZIP) transcription factor that lacks a transactivation domain. It is known to bind the US-2 DNA element in the promoter of the oxytocin receptor (OTR) gene and most likely heterodimerizes with other leucine zipper-containing proteins to enhance expression of the OTR gene during term pregnancy. The encoded protein can also form homodimers, and since it lacks a transactivation domain, the homodimer may act as a repressor of transcription. This gene may also be involved in the cellular stress response. Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Jun 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DV49;Q9Y525",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0045604 regulation of epidermal cell differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q9ULX9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00462-1",
        "uniprot_id": [
            {
                "id": "MANBA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00462",
                "type": "external"
            }
        ],
        "mass": 100895.0,
        "length": 879,
        "protein_name": "Beta-mannosidase",
        "gene_name": "MANBA",
        "organism": "Human",
        "refseq_name": "beta-mannosidase precursor",
        "refseq_ac": [
            {
                "id": "NP_005899",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005899",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MANBA; MANB1",
        "gene_names_refseq": "MANB1; MANBA",
        "protein_names_uniprotkb": "Beta-mannosidase; 3.2.1.25; Lysosomal beta A mannosidase; Mannanase; Mannase",
        "protein_names_refseq": "beta-mannosidase A; beta-mannosidase precursor; lysosomal beta A mannosidase; mannanase; mannase; mannosidase, beta A, lysosomal",
        "tax_id": 9606,
        "disease": "beta-mannosidosis (Disease Ontology:DOID:3633)",
        "pathway": " (hsa:4126);  (R-HSA-6798695);  (R-HSA-8853383)",
        "pathway_count": 3,
        "publication_count": 79,
        "publication_id_list": "10.1101/2023.09.13.557529;10513892;11237011;11350179;12468273;12890191;1499588;1576208;16115860;1623631;16401745;16848760;16904924;17420068;17899454;18565776;19722277;23090970;23481700;23650620;24190977;24715725;25345101;25576301;25762455;25880248;27846572;27862975;28467828;28904123;29242379;29317506;29557506;29741879;30315122;30528300;30552791;30573663;30779550;31154438;31217245;31611695;31844290;31848261;31998317;32157095;32350084;32357974;32502341;32938616;32983136;33043033;33123756;33392160;33441424;33592498;33717175;33981976;34087483;34357683;34433824;34870556;34932366;35051231;35154160;35251023;35494241;35580925;35897697;36010968;36241641;36284347;37074911;3762648;38665916;39302247;8692836;8910458;9384606",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "A novel genetic variant potentially altering the expression of MANBA in the cerebellum associated with attention deficit hyperactivity disorder in Han Chinese children., [RefSeq, PubMed]; Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB]; Impact of Multiple Sclerosis Risk Polymorphism rs7665090 on MANBA Activity, Lysosomal Endocytosis, and Lymphocyte Activation. Publication Status: Online-Only, [RefSeq, PubMed]; Independent putative primary functional variants in NFKB1/MANBA and showed the distinct molecular mechanism by which each putative primary functional variant conferred susceptibility to Primary biliary cholangitis, were identified., [RefSeq, PubMed]; Kidney disease genetic risk variants alter lysosomal beta-mannosidase (MANBA) expression and disease severity., [RefSeq, PubMed]; The MANBA genotypes for a polymorphic CA repeat were related to colorectal cancer risk in a Swedish population but not a Chinese one. In the Swedish population, individuals with < 22 CAs/< 22 CAs had a significantly increased risk for CRC. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a member of the glycosyl hydrolase 2 family. The encoded protein localizes to the lysosome where it is the final exoglycosidase in the pathway for N-linked glycoprotein oligosaccharide catabolism. Mutations in this gene are associated with beta-mannosidosis, a lysosomal storage disease that has a wide spectrum of neurological involvement. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 1170,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 14,
        "disease_count": 1,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96BC3;Q9NYX9",
        "ec_number_list": [
            {
                "id": "3.2.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.25",
                "type": "external"
            },
            {
                "id": "3.5.1.92",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.92",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.2.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20",
                "type": "external"
            },
            {
                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
                "type": "external"
            },
            {
                "id": "2.4.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-",
                "type": "external"
            },
            {
                "id": "2.4.1.275",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275",
                "type": "external"
            },
            {
                "id": "2.4.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22",
                "type": "external"
            },
            {
                "id": "2.4.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38",
                "type": "external"
            },
            {
                "id": "2.4.1.90",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.4.16.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2",
                "type": "external"
            },
            {
                "id": "3.4.23.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-",
                "type": "external"
            },
            {
                "id": "7.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67",
                "type": "external"
            },
            {
                "id": "2.3.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25",
                "type": "external"
            },
            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004567 beta-mannosidase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0035577 azurophil granule membrane;GO:0043202 lysosomal lumen;GO:0005764 lysosome",
        "go_biological_process": "GO:0036211 protein modification process;GO:0009313 oligosaccharide catabolic process;GO:0006516 glycoprotein catabolic process;GO:0005975 carbohydrate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.7,
        "record_id": "O00462-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000010001.101.10100",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q02080-1",
        "uniprot_id": [
            {
                "id": "MEF2B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q02080",
                "type": "external"
            }
        ],
        "mass": 38639.0,
        "length": 365,
        "protein_name": "Myocyte-specific enhancer factor 2B",
        "gene_name": "MEF2B",
        "organism": "Human",
        "refseq_name": "myocyte-specific enhancer factor 2B isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001139257",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139257",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MEF2B; XMEF2",
        "gene_names_refseq": "MEF2B; RSRFR2",
        "protein_names_uniprotkb": "Myocyte-specific enhancer factor 2B; RSRFR2; Serum response factor-like protein 2",
        "protein_names_refseq": "MADS box transcription enhancer factor 2, polypeptide B (myocyte enhancer factor 2B); myocyte-specific enhancer factor 2B isoform 1; myocyte-specific enhancer factor 2B; serum response factor-like protein 2",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); intellectual disability (Disease Ontology:DOID:1059); attention deficit hyperactivity disorder (Disease Ontology:DOID:1094)",
        "pathway": " (hsa:100271849);  (hsa:4207);  (R-HSA-525793)",
        "pathway_count": 3,
        "publication_count": 43,
        "publication_id_list": "10330143;10601328;10805738;11237011;11782431;12634428;12700764;1516833;15567413;1748287;19564926;20160094;22424782;25880248;26631611;26992070;27846572;28063628;28832583;28904123;29393594;29632046;30379171;31844290;32357974;32387766;32502341;32738045;33141586;33298915;33691108;33912179;34418874;34509645;34932366;35051231;35528192;39179580;9069290;9418854;9786951;9858528;9988769",
        "class_list": "",
        "function": "Landscape of DNA binding signatures of myocyte enhancer factor-2B reveals a unique interplay of base and shape readout., [RefSeq, PubMed]; MEF2B C-terminal mutations enhance transcriptional activity and stability to drive B cell lymphomagenesis. Publication Status: Online-Only, [RefSeq, PubMed]; Systematic transition modeling analysis in the MEF2B-DNA binding interface due to Y69H and K4E variants., [RefSeq, PubMed]; The Genetic Landscape of Ocular Adnexa MALT Lymphoma Reveals Frequent Aberrations in NFAT and MEF2B Signaling Pathways. Erratum:[Cancer Res Commun. 2023 Aug 29;3(8):1688. doi: 10.1158/2767-9764.CRC-23-0371. PMID: 37649813], [RefSeq, PubMed]; The product of this gene is a member of the MADS/MEF2 family of DNA binding proteins. The protein is thought to regulate gene expression, including expression of the smooth muscle myosin heavy chain gene. This region undergoes considerable alternative splicing, with transcripts supporting two non-overlapping loci (GeneID 729991 and 100271849) as well as numerous read-through transcripts that span both loci (annotated as GeneID 4207). Several isoforms of this protein are expressed from either this locus or from some of the read-through transcripts annotated on GeneID 4207. [provided by RefSeq, Jan 2014]., [RefSeq]; Transcriptional activator which binds specifically to the MEF2 element, 5'-YTA[AT](4)TAR-3', found in numerous muscle-specific genes. Activates transcription via this element. May be involved in muscle-specific and/or growth factor-related transcription., [UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AV80;B4DVH7;B7ZVY1;G5E9M1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0042826 histone deacetylase binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005667 transcription regulator complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007507 heart development;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "Q02080-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZN01-1",
        "uniprot_id": [
            {
                "id": "MASTR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZN01",
                "type": "external"
            }
        ],
        "mass": 44632.0,
        "length": 415,
        "protein_name": "MEF2-activating motif and SAP domain-containing transcriptional regulator",
        "gene_name": "MAMSTR",
        "organism": "Human",
        "refseq_name": "MEF2-activating motif and SAP domain-containing transcriptional regulator isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001124387",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124387",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAMSTR; MASTR",
        "gene_names_refseq": "MAMSTR; MASTR",
        "protein_names_uniprotkb": "MEF2-activating motif and SAP domain-containing transcriptional regulator; MEF2-activating SAP transcriptional regulatory protein",
        "protein_names_refseq": "MEF2-activating SAP transcriptional regulatory protein; MEF2-activating motif and SAP domain-containing transcriptional regulator isoform 1; likely ortholog of MEF2-activating SAP transcriptional regulator",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284358)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;16818234;30379171;31217245",
        "class_list": "",
        "function": "Transcriptional coactivator. Stimulates the transcriptional activity of MEF2C. Stimulates MYOD1 activity in part via MEF2, resulting in an enhancement of skeletal muscle differentiation (By similarity)., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZKX4;Q3KQU9;Q8N9Y3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003712 transcription coregulator activity",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q6ZN01-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15243-1",
        "uniprot_id": [
            {
                "id": "OBRG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15243",
                "type": "external"
            }
        ],
        "mass": 14254.0,
        "length": 131,
        "protein_name": "Leptin receptor gene-related protein",
        "gene_name": "LEPROT",
        "organism": "Human",
        "refseq_name": "leptin receptor gene-related protein isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001185612",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185612",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LEPROT; LEPR; OBR",
        "gene_names_refseq": "LEPROT; OB-RGRP; OBRGRP; VPS55",
        "protein_names_uniprotkb": "Leptin receptor gene-related protein; Endospanin-1; Leptin receptor overlapping transcript protein; OB-R gene-related protein; OB-RGRP",
        "protein_names_refseq": "DnaJ (Hsp40) homolog, subfamily C, member 6; OB-R gene-related protein; endospanin-1; leptin receptor gene-related protein isoform 3; leptin receptor gene-related protein; leptin receptor overlapping transcript protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54741)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;16303743;18042720;19907080;19913121;20628086;21654843;25645385;28904123;29242379;29393594;29557506;29632711;30484775;30833945;31154438;31844290;33592498;34171305;34357683;35154160;35580925;36215666;36241641;38716728;9207021",
        "class_list": "",
        "function": "LEPROT is associated with the Golgi complex and endosomes and has a role in cell surface expression of growth hormone receptor (GHR; MIM 600946) and leptin receptor (OBR, or LEPR; MIM 601007), thereby altering receptor-mediated cell signaling (Couturier et al., 2007 [PubMed 18042720]; Touvier et al., 2009 [PubMed 19907080]).[supplied by OMIM, Jul 2010]., [RefSeq]; Negatively regulates leptin receptor (LEPR) cell surface expression, and thus decreases response to leptin. Negatively regulates growth hormone (GH) receptor cell surface expression in liver. May play a role in liver resistance to GH during periods of reduced nutrient availability., [UniProtKB, PubMed, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Transgenic mice expressing either human LEPROT or human LEPROTL1 displayed growth retardation, reduced plasma IGF1 levels, and impaired hepatic sensitivity to GH, as measured by STAT5 phosphorylation and Socs2 mRNA expression., [RefSeq, PubMed]; Whole-body deletion of Endospanin 1 protects from obesity-associated deleterious metabolic alterations. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6FHL5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0060400 negative regulation of growth hormone receptor signaling pathway;GO:1903955 positive regulation of protein targeting to mitochondrion;GO:2000009 negative regulation of protein localization to cell surface;GO:0046426 negative regulation of receptor signaling pathway via JAK-STAT;GO:0032511 late endosome to vacuole transport via multivesicular body sorting pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
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        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
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    },
    {
        "uniprot_canonical_ac": "Q96Q04-1",
        "uniprot_id": [
            {
                "id": "LMTK3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96Q04",
                "type": "external"
            }
        ],
        "mass": 153661.0,
        "length": 1460,
        "protein_name": "Serine/threonine-protein kinase LMTK3",
        "gene_name": "LMTK3",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase LMTK3 precursor",
        "refseq_ac": [
            {
                "id": "NP_001073903",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073903",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LMTK3; KIAA1883; TYKLM3",
        "gene_names_refseq": "AATYK3; LMR3; LMTK3; PPP1R101; TYKLM3",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase LMTK3; 2.7.11.1; Lemur tyrosine kinase 3",
        "protein_names_refseq": "protein phosphatase 1, regulatory subunit 101; serine/threonine-protein kinase LMTK3 precursor; serine/threonine-protein kinase LMTK3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:114783)",
        "pathway_count": 1,
        "publication_count": 31,
        "publication_id_list": "11237011;21602804;21671015;22869149;23481700;23918832;24715725;25892735;26154972;26992070;28218747;28657654;28834231;29437277;29540829;30192525;30242244;30944027;31092671;32161166;32387766;32865871;33141586;33298915;33981976;34087483;34211107;34509645;34516351;35051231;35580925",
        "class_list": "",
        "function": "Abundance and intronic polymorphism associated with breast cancer survival and response to endocrine therapies, [RefSeq, PubMed]; Harboring rs8108419 G/G genotype of the LMTK3 was associated with OS in the Japanese females (HR, 3.04; 95% CI, 1.08-8.56; P = 0.035) and the U.S. males (HR, 3.39; 95% CI, 1.31-8.80; P = 0.012)., [RefSeq, PubMed]; Higher LMTK3 expression is associated with more aggressive breast cancers., [RefSeq, PubMed]; LMTK3 expression and its role in the drug resistance in breast cancer., [RefSeq, PubMed]; LMTK3 promotes tumorigenesis in bladder cancer via the ERK/MAPK pathway. Erratum:[FEBS Open Bio. 2021 Apr;11(4):1277. doi: 10.1002/2211-5463.13116. PMID: 33794072], [RefSeq, PubMed]; Lemur tyrosine kinase-3 (LMTK3) induces chemoresistance to cetuximab in colorectal cancer via the ERK/MAPK pathway., [RefSeq, PubMed]; Our findings support a model in which the MIR2052HG regulates LMTK3 via EGR1, and LMTK3 regulates ERalpha stability via the PKC/MEK/ERK/RSK1 axis. These results reveal a direct role of MIR2052HG in LMTK3 regulation and raise the possibilities of targeting MIR2052HG or LMTK3 in ERalpha-positive breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Protein kinase which phosphorylates ESR1 (in vitro) and protects it against proteasomal degradation. May also regulate ESR1 levels indirectly via a PKC-AKT-FOXO3 pathway where it decreases the activity of PKC and the phosphorylation of AKT, thereby increasing binding of transcriptional activator FOXO3 to the ESR1 promoter and increasing ESR1 transcription (PubMed:21602804). Involved in endocytic trafficking of N-methyl-D-aspartate receptors (NMDAR) in neurons (By similarity)., [UniProtKB, UniProtKB, PubMed]; Role for LMTK3 in both innate (intrinsic) and acquired (adaptive) endocrine resistance in breast cancer, [RefSeq, PubMed]; Targeting of LMTK3 with siRNA delayed KIT-dependent GIST growth in a xenograft model. Our data suggest the potential of LMTK3 as a target for treatment of patients with KIT-mutant cancer, particularly after failure of KIT TKIs., [RefSeq, PubMed]",
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        "predicted_o_glycosites": 3,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4G0U1",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
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            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
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            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
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            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
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            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
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            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
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                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
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                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
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            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
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            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
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            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
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                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
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                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
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            {
                "id": "3.1.11.-",
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                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
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                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
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                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
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            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
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            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
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            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
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            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
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            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
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            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
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            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
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            {
                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
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            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004672 protein kinase activity;GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q96Q04-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q2VPJ9-1",
        "uniprot_id": [
            {
                "id": "LR75B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q2VPJ9",
                "type": "external"
            }
        ],
        "mass": 34740.0,
        "length": 315,
        "protein_name": "Leucine-rich repeat-containing protein 75B",
        "gene_name": "LRRC75B",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 75B",
        "refseq_ac": [
            {
                "id": "NP_997527",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997527",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC75B; C22orf36; FAM211B",
        "gene_names_refseq": "C22orf36; FAM211B; LRRC75B",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 75B; Leucine-rich repeat-containing protein FAM211B",
        "protein_names_refseq": "family with sequence similarity 211, member B; leucine-rich repeat-containing protein 75B; leucine-rich repeat-containing protein C22orf36; leucine-rich repeat-containing protein FAM211B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:388886)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;18477386;28904123;31492838;31844290",
        "class_list": "",
        "function": "May suppress myogenic differentiation by modulating MYOG expression and Erk1/2 signaling., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "secondary_ac_list": "Q8N0S9;Q8N8B1",
        "ec_number_list": [],
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        "go_biological_process": "",
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        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "SCMH1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96GD3",
                "type": "external"
            }
        ],
        "mass": 73354.0,
        "length": 660,
        "protein_name": "Polycomb protein SCMH1",
        "gene_name": "SCMH1",
        "organism": "Human",
        "refseq_name": "polycomb protein SCMH1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001026864",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026864",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SCMH1",
        "gene_names_refseq": "SCMH1; Scml3",
        "protein_names_uniprotkb": "Polycomb protein SCMH1; Sex comb on midleg homolog 1",
        "protein_names_refseq": "polycomb protein SCMH1 isoform a; polycomb protein SCMH1; sex comb on midleg homolog 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22955)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "10.1101/2023.09.13.557529;10524249;11237011;12167701;17081983;18491316;19266077;20546612;25576301;26992070;27846572;29557506;30379171;31844290;31848261;32157095;32387766;32938616;33592498;33912179;33968037;35051231",
        "class_list": "",
        "function": "Associates with Polycomb group (PcG) multiprotein complexes; the complex class is required to maintain the transcriptionally repressive state of some genes., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DRQ8;Q5VT76;Q6IAJ4;Q8WU48;Q9UKM5;Q9UKM6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0010369 chromocenter",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0031507 heterochromatin formation;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q96GD3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P47985-1",
        "uniprot_id": [
            {
                "id": "UCRI_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P47985",
                "type": "external"
            }
        ],
        "mass": 29668.0,
        "length": 274,
        "protein_name": "Cytochrome b-c1 complex subunit Rieske, mitochondrial",
        "gene_name": "UQCRFS1",
        "organism": "Human",
        "refseq_name": "cytochrome b-c1 complex subunit Rieske, mitochondrial",
        "refseq_ac": [
            {
                "id": "NP_005994",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005994",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UQCRFS1",
        "gene_names_refseq": "ISP; MC3DN10; RIP1; RIS1; RISP; UQCR5; UQCRFS1",
        "protein_names_uniprotkb": "Cytochrome b-c1 complex subunit Rieske, mitochondrial; 7.1.1.8; 8 kDa subunit 9; Complex III subunit 5; Complex III subunit IX; Cytochrome b-c1 complex subunit 11; Cytochrome b-c1 complex subunit 5; RISP; Rieske iron-sulfur protein; Rieske protein UQCRFS1; UQCRFS1 MTS; UQCRFS1 mitochondrial targeting sequence; Ubiquinol-cytochrome c reductase 8 kDa protein; Ubiquinol-cytochrome c reductase iron-sulfur subunit",
        "protein_names_refseq": "Complex III subunit 9; Rieske iron-sulfur protein; Rieske protein UQCRFS1; Subunit 9; complex III subunit 5; cytochrome b-c1 complex subunit 5; cytochrome b-c1 complex subunit Rieske, mitochondrial; epididymis secretory sperm binding protein; ubiquinol-cytochrome c reductase iron-sulfur subunit",
        "tax_id": 9606,
        "disease": "mitochondrial complex III deficiency (Disease Ontology:DOID:0111139); mitochondrial metabolism disease (Disease Ontology:DOID:700); mitochondrial complex III deficiency, nuclear type 10 (MONDO:MONDO:0032909)",
        "pathway": " (hsa:7386);  (R-HSA-611105);  (R-HSA-9865881)",
        "pathway_count": 3,
        "publication_count": 88,
        "publication_id_list": "10327278;11695836;12231006;12837546;1327877;14741580;15250827;16230336;17033964;186667;21278747;2158323;23150584;23168492;23270816;23564345;23747254;239860;24366607;24385928;25008109;25564869;25576301;25605331;25880248;26154972;26992070;27452731;27600516;27846572;27920218;28063628;28228285;28380382;28649982;28673544;28832583;28844695;29242379;29243944;29393594;29508533;29632046;29769354;29786170;30192525;30315122;30379171;30429286;30524438;30779550;31217245;31530632;31844290;31883641;31974161;31998317;32157095;32265295;32488085;32502341;32669538;32929120;32938616;32983136;33141586;33298915;33592498;33936100;33968037;34133725;34211107;34357683;34405274;34509645;34561969;34725712;34969438;35051231;35580925;36215666;36241641;40596516;40914422;4288886;7721092;9150947;9878551",
        "class_list": "",
        "function": "Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII). UQCRFS1 undergoes proteolytic processing once it is incorporated in the complex III dimer. One of the fragments, called subunit 9, corresponds to its mitochondrial targeting sequence (MTS). The proteolytic processing is necessary for the correct insertion of UQCRFS1 in the complex III dimer, but the persistence of UQCRFS1-derived fragments may prevent newly imported UQCRFS1 to be processed and assembled into complex III and is detrimental for the complex III structure and function., [UniProtKB, PubMed]; Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation (PubMed:31883641). The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c. The Rieske protein is a catalytic core subunit containing a [2Fe-2S] iron-sulfur cluster. It cycles between 2 conformational states during catalysis to transfer electrons from the quinol bound in the Q(0) site in cytochrome b to cytochrome c1 (By similarity). Incorporation of UQCRFS1 is the penultimate step in complex III assembly (PubMed:28673544)., [UniProtKB, PubMed, UniProtKB, PubMed]; Pulse-chase SILAC-based analyses reveal selective oversynthesis and rapid turnover of mitochondrial protein components of respiratory complexes., [RefSeq, PubMed]; Rieske iron-sulfur protein induces FKBP12.6/RyR2 complex remodeling and subsequent pulmonary hypertension through NF-kappaB/cyclin D1 pathway. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K519;Q6NVX5;Q9UPH2",
        "ec_number_list": [
            {
                "id": "7.1.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.1.1.8",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "1.16.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding;GO:0016491 oxidoreductase activity;GO:0008121 quinol-cytochrome-c reductase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0045275 respiratory chain complex III",
        "go_biological_process": "GO:0022904 respiratory electron transport chain;GO:0034551 mitochondrial respiratory chain complex III assembly;GO:0006122 mitochondrial electron transport, ubiquinol to cytochrome c",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "P47985-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75132-1",
        "uniprot_id": [
            {
                "id": "ZBED4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75132",
                "type": "external"
            }
        ],
        "mass": 130322.0,
        "length": 1171,
        "protein_name": "Zinc finger BED domain-containing protein 4",
        "gene_name": "ZBED4",
        "organism": "Human",
        "refseq_name": "zinc finger BED domain-containing protein 4",
        "refseq_ac": [
            {
                "id": "NP_055653",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055653",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZBED4; KIAA0637",
        "gene_names_refseq": "ZBED4",
        "protein_names_uniprotkb": "Zinc finger BED domain-containing protein 4",
        "protein_names_refseq": "zinc finger BED domain-containing protein 4; zinc finger, BED domain containing 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9889)",
        "pathway_count": 1,
        "publication_count": 61,
        "publication_id_list": "17209048;19369242;20238005;22693546;23186163;23481700;24397554;24715725;25576301;25645385;25880248;26154972;26375851;26811146;26992070;27600516;27862975;28228285;28832583;28904123;29242379;29393594;29557506;29632046;29794561;30315122;30379171;30410026;30524438;30779550;31154438;31217245;31530632;31844290;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33912179;33936100;33968037;33981976;34087483;34185709;34509645;34561969;34932366;35051231;35580925;36010968;36241641",
        "class_list": "",
        "function": "There was no association between SNPs in the BRD1 and ZBED4 genes and schizophrenia in the Chinese population., [RefSeq, PubMed]; Transcriptional regulator that binds to poly-guanine tracts in gene promoters and activates transcription (By similarity). Able to bind single- and double-stranded DNA and RNA (By similarity)., [UniProtKB, UniProtKB]; ZBED4 cellular/subcellular localization and domains suggest a regulatory role for this protein, which may exert its effects in cones and Muller cells through multiple ways of action., [RefSeq, PubMed]; ZBED4, a novel protein that in human retina is localized to cone photoreceptors and glial Muller cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 26,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RZH1;Q1ECU0;Q9UGG8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0001917 photoreceptor inner segment;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "O75132-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6XYB7-1",
        "uniprot_id": [
            {
                "id": "LBX2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6XYB7",
                "type": "external"
            }
        ],
        "mass": 21482.0,
        "length": 198,
        "protein_name": "Transcription factor LBX2",
        "gene_name": "LBX2",
        "organism": "Human",
        "refseq_name": "transcription factor LBX2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001009812",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009812",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LBX2; LP3727",
        "gene_names_refseq": "LBX2; LP3727",
        "protein_names_uniprotkb": "Transcription factor LBX2; Ladybird homeobox 2; Ladybird homeobox protein homolog 2",
        "protein_names_refseq": "ladybird homeobox protein homolog 2; ladybird-like homeobox 2; ladybird-like homeodomain protein 2; transcription factor LBX2 isoform 2; transcription factor LBX2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:85474)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "11237011;11386758;15498874;29393594;29669692;32559617;32567804;35580925;38520216",
        "class_list": "",
        "function": "Histone modification-linked prognostic model for ovarian cancer reveals LBX2 as a novel growth promoter., [RefSeq, PubMed]; Identification of LBX2 as a novel causal gene of lung adenocarcinoma., [RefSeq, PubMed]; LBX2 was identified as a pathogenic gene in Chinese patients with atrial septal defect., [RefSeq, PubMed]; LncRNA LBX2-AS1 facilitates abdominal aortic aneurysm through miR-4685-5p/LBX2 feedback loop., [RefSeq, PubMed]; Transcription factor., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z5Y8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0042692 muscle cell differentiation;GO:2000052 positive regulation of non-canonical Wnt signaling pathway;GO:1904105 positive regulation of convergent extension involved in gastrulation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q6XYB7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UJA3-1",
        "uniprot_id": [
            {
                "id": "MCM8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UJA3",
                "type": "external"
            }
        ],
        "mass": 93697.0,
        "length": 840,
        "protein_name": "DNA helicase MCM8",
        "gene_name": "MCM8",
        "organism": "Human",
        "refseq_name": "DNA helicase MCM8 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001268449",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268449",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MCM8; C20orf154",
        "gene_names_refseq": "C20orf154; MCM8; POF10; dJ967N21.5",
        "protein_names_uniprotkb": "DNA helicase MCM8; 5.6.2.4; DNA 3'-5' helicase MCM8; Minichromosome maintenance 8",
        "protein_names_refseq": "DNA 3'-5' helicase MCM8; DNA helicase MCM8 isoform 1; DNA helicase MCM8; DNA replication licensing factor MCM8; MCM8 minichromosome maintenance deficient 8; REC homolog; minichromosome maintenance complex component 8",
        "tax_id": 9606,
        "disease": "primary ovarian insufficiency 10 (Disease Ontology:DOID:0080867)",
        "pathway": " (hsa:84515);  (R-HSA-113507);  (R-HSA-176187);  (R-HSA-176974);  (R-HSA-68689);  (R-HSA-68949);  (R-HSA-68962)",
        "pathway_count": 7,
        "publication_count": 120,
        "publication_id_list": "10051570;10373362;10373557;10518787;10523313;10757793;10777662;10827953;10846177;10859164;10882098;11095689;11125146;11390642;11739726;11931757;12045100;12399544;12527764;12578958;12676583;12676925;12759351;12771218;12791985;12963847;14500360;14603323;14605214;14624239;15190204;15226314;15684404;15707391;15707891;15743907;15833913;16325355;16327781;16407120;17417653;18072282;18480045;19448619;22405012;23186163;23401855;23481700;23851460;25231993;25418920;25437880;25576301;25762138;25880248;25892735;26215093;26300262;26811146;26992070;27600516;28112645;28218747;28228285;28514659;28649982;28832583;28834231;28904123;29242379;29331515;29393594;29508533;29632046;29769354;29789417;29899147;30315122;31217245;31467087;31530632;31844290;32157095;32357974;32387766;32488085;32502341;32848132;32897882;32938616;33141586;33298915;33592498;33691108;33717175;33912179;33936100;33968037;34043945;34131285;34171305;34509645;34561969;34932366;35051231;36010968;36241641;36355348;37309874;37535404;38588931;38678026;38988047;39031896;39074937;8196638;8943031;9278511;9278512;9660782",
        "class_list": "",
        "function": "A novel cancer-germline gene DAZL promotes progression and cisplatin resistance of non-small cell lung cancer by upregulating JAK2 and MCM8., [RefSeq, PubMed]; Component of the MCM8-MCM9 complex, which is involved in the repair of double-stranded DNA breaks (DBSs) and DNA interstrand cross-links (ICLs) by homologous recombination (HR) (PubMed:23401855). The MCM8-MCM9 complex is a 3'-5' DNA helicase and single-stranded (ss)DNA-stimulated ATPase which binds ssDNA in the presence of nucleoside triphosphates (PubMed:37309874). Required for DNA resection by the MRE11-RAD50-NBN/NBS1 (MRN) complex by recruiting the MRN complex to the repair site and by promoting the complex nuclease activity (PubMed:26215093). Indirectly regulates the recruitment of downstream effector RAD51 to DNA damage sites including DBSs and ICLs, probably by regulating the localization of the MNR complex (PubMed:23401855). The MCM8-MCM9 complex is dispensable for DNA replication and S phase progression (PubMed:23401855). May play a non-essential for DNA replication: may be involved in the activation of the prereplicative complex (pre-RC) during G(1) phase by recruiting CDC6 to the origin recognition complex (ORC) (PubMed:15684404). Facilitates somatic mitochondrial (mt)DNA recombination (PubMed:36355348). Plays a key role during gametogenesis, probably by regulating HR (By similarity). Stabilizes MCM9 protein (PubMed:23401855, PubMed:26215093)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; MCM8 is a crucial component of the pre-RC and that the interaction between hMCM8 and hcdc6 is required for pre-RC assembly., [RefSeq, PubMed]; MCM8 promotes gastric cancer progression through RPS15A and predicts poor prognosis., [RefSeq, PubMed]; MCM8 promotes lung cancer progression through upregulating DNAJC10., [RefSeq, PubMed]; Mechanism of DNA unwinding by MCM8-9 in complex with HROB. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The MCM8 gene is located contrapodal to GCD10 at chromosome band 20p12.3-13., [RefSeq, PubMed]; The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2013]., [RefSeq]; Understanding the novel MCM8 gene mutation: primary ovarian insufficiency and uterine hypoplasia in siblings. Publication Status: Online-Only, [RefSeq, PubMed]; We find that MCM8, like MCM7, colocalizes on a specific DNA segment of the c-MYC replication initiation zone (c-MYC replicator) of DNA replications together with Cdc6 and cdk2, but differs with MCM7 in spatial relation to RPA70 during S phase., [RefSeq, PubMed]",
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        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBG7;D3DW08;E7EQU7;Q495R4;Q495R6;Q495R7;Q86US4;Q969I5",
        "ec_number_list": [
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        ],
        "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0019899 enzyme binding;GO:0016887 ATP hydrolysis activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005759 mitochondrial matrix;GO:0005694 chromosome;GO:0097362 MCM8-MCM9 complex",
        "go_biological_process": "GO:0006974 DNA damage response;GO:0050821 protein stabilization;GO:0000724 double-strand break repair via homologous recombination;GO:0007292 female gamete generation;GO:0071168 protein localization to chromatin",
        "synthesized_glycan_count": 0,
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        "record_id": "Q9UJA3-1",
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    },
    {
        "uniprot_canonical_ac": "P20783-1",
        "uniprot_id": [
            {
                "id": "NTF3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P20783",
                "type": "external"
            }
        ],
        "mass": 29355.0,
        "length": 257,
        "protein_name": "Neurotrophin-3",
        "gene_name": "NTF3",
        "organism": "Human",
        "refseq_name": "neurotrophin-3 isoform 1 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_001096124",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096124",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NTF3",
        "gene_names_refseq": "HDNF; NGF-2; NGF2; NT-3; NT3; NTF3",
        "protein_names_uniprotkb": "Neurotrophin-3; HDNF; NGF-2; NT-3; Nerve growth factor 2; Neurotrophic factor",
        "protein_names_refseq": "nerve growth factor 2; neurotrophic factor; neurotrophin-3 isoform 1 preproprotein",
        "tax_id": 9606,
        "disease": "atrial heart septal defect 1 (Disease Ontology:DOID:0110106); Alzheimer's disease (Disease Ontology:DOID:10652); hydrocephalus (Disease Ontology:DOID:10908); pulmonary sarcoidosis (Disease Ontology:DOID:13406); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); asthma (Disease Ontology:DOID:2841); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); borna disease (Disease Ontology:DOID:5154); tetralogy of Fallot (Disease Ontology:DOID:6419)",
        "pathway": " (hsa:4908);  (R-HSA-1257604);  (R-HSA-2219530);  (R-HSA-6811558);  (R-HSA-9025046);  (R-HSA-9034013);  (R-HSA-9034015);  (R-HSA-9034793);  (R-HSA-9034864);  (R-HSA-9603381)",
        "pathway_count": 10,
        "publication_count": 75,
        "publication_id_list": "10191262;10486198;10579907;11147812;11520916;11803464;12167717;12767043;1325671;15718470;15834429;16339315;16456541;16647110;17200115;17626883;17991742;18079394;18317450;18594509;18606717;18754654;18755892;18829560;1889806;18925875;19185485;19411071;19576174;19644473;19805105;19962665;20231295;2025430;20338997;20522708;20713702;21188471;21317208;21368164;21478295;21668414;21827948;21976531;21984976;22120714;22188813;2236018;22588880;22802530;2344409;2365067;25196463;29242379;29557506;31154438;31848261;32938616;34445205;34508100;36010968;36263167;37272057;37848983;7637810;7703225;7733919;7744773;7796806;7961713;8645157;8657148;8925252;9736715;9895304",
        "class_list": "",
        "function": "Adipose tissue-derived neurotrophic factor 3 regulates sympathetic innervation and thermogenesis in adipose tissue. Publication Status: Online-Only, [RefSeq, PubMed]; Expression and prognostic impact of NTF3 and TrkC in hepatocellular carcinoma., [RefSeq, PubMed]; Neurotrophin-3 promotes peripheral nerve regeneration by maintaining a repair state of Schwann cells after chronic denervation via the TrkC/ERK/c-Jun pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Neurotrophin3 promotes hepatocellular carcinoma apoptosis through the JNK and P38 MAPK pathways. Publication Status: Online-Only, [RefSeq, PubMed]; Seems to promote the survival of visceral and proprioceptive sensory neurons., [UniProtKB]; The Role of the Second Extracellular Loop of Norepinephrine Transporter, Neurotrophin-3 and Tropomyosin Receptor Kinase C in T Cells: A Peripheral Biomarker in the Etiology of Schizophrenia. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the neurotrophin family, that controls survival and differentiation of mammalian neurons. This protein is closely related to both nerve growth factor and brain-derived neurotrophic factor. It may be involved in the maintenance of the adult nervous system, and may affect development of neurons in the embryo when it is expressed in human placenta. NTF3-deficient mice generated by gene targeting display severe movement defects of the limbs. The mature peptide of this protein is identical in all mammals examined including human, pig, rat and mouse. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "disease_count": 10,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z1T5;Q6FH50",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042056 chemoattractant activity;GO:0008083 growth factor activity;GO:0005163 nerve growth factor receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0008021 synaptic vesicle",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007267 cell-cell signaling;GO:0007399 nervous system development;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.6,
        "record_id": "P20783-1",
        "record_type": "protein",
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    },
    {
        "uniprot_canonical_ac": "Q14582-1",
        "uniprot_id": [
            {
                "id": "MAD4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14582",
                "type": "external"
            }
        ],
        "mass": 23528.0,
        "length": 209,
        "protein_name": "Max dimerization protein 4",
        "gene_name": "MXD4",
        "organism": "Human",
        "refseq_name": "max dimerization protein 4",
        "refseq_ac": [
            {
                "id": "NP_006445",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006445",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MXD4; BHLHC12; MAD4",
        "gene_names_refseq": "MAD4; MST149; MSTP149; MXD4; bHLHc12",
        "protein_names_uniprotkb": "Max dimerization protein 4; Class C basic helix-loop-helix protein 12; Max dimerizer 4; Max-associated protein 4; Max-interacting transcriptional repressor MAD4; bHLHc12",
        "protein_names_refseq": "Mad4 homolog; class C basic helix-loop-helix protein 12; max dimerization protein 4; max dimerizer 4; max-associated protein 4; max-interacting transcriptional repressor MAD4",
        "tax_id": 9606,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:10608);  (R-HSA-1251985)",
        "pathway_count": 2,
        "publication_count": 56,
        "publication_id_list": "11237011;11679632;12418961;12807903;15023535;15469726;15534001;16061658;16912174;17018285;18653779;19047365;19596786;22895069;23230144;23481700;24308844;24715725;24829397;25418920;25576301;25880248;26154972;26375851;27846572;27920218;28063628;28228285;28514659;28832583;29242379;29493099;29508533;29557506;29632046;30315122;30429286;31154438;31844290;31848261;32157095;32265295;32387766;32502341;32983136;33298915;33714983;33968037;33981976;34211107;34509645;35051231;35580925;36007550;36302855;37938771",
        "class_list": "",
        "function": "Data suggest that the biological function of the interaction between T-complex protein 10-like and MAD4 may be to maintain the differentiation state in liver cells., [RefSeq, PubMed]; MXD4/MAD4 Regulates Human Keratinocyte Precursor Fate., [RefSeq, PubMed]; NUTM1-rearranged colorectal sarcoma: a clinicopathologically and genetically distinctive malignant neoplasm with a poor prognosis., [RefSeq, PubMed]; Regulation by a transcriptional repressor complex that contains Miz-1 and c-Myc, [RefSeq, PubMed]; Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia., [RefSeq, PubMed]; The E3 ligase activity of c-IAP1 was not required for downregulation of Mad4 expression., [RefSeq, PubMed]; This gene is a member of the MAD gene family . The MAD genes encode basic helix-loop-helix-leucine zipper proteins that heterodimerize with MAX protein, forming a transcriptional repression complex. The MAD proteins compete for MAX binding with MYC, which heterodimerizes with MAX forming a transcriptional activation complex. Studies in rodents suggest that the MAD genes are tumor suppressors and contribute to the regulation of cell growth in differentiating tissues. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional repressor. Binds with MAX to form a sequence-specific DNA-binding protein complex which recognizes the core sequence 5'-CAC[GA]TG-3'. Antagonizes MYC transcriptional activity by competing for MAX and suppresses MYC dependent cell transformation (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
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        "reported_snv": 1,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A335;Q5TZX4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q14582-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14CX5-1",
        "uniprot_id": [
            {
                "id": "S68A1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14CX5",
                "type": "external"
            }
        ],
        "mass": 57381.0,
        "length": 517,
        "protein_name": "Solute carrier family 68 member 1",
        "gene_name": "SLC68A1",
        "organism": "Human",
        "refseq_name": "solute carrier family 68 member 1",
        "refseq_ac": [
            {
                "id": "NP_079065",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079065",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC68A1; C10orf77; MFSD13A; TMEM180",
        "gene_names_refseq": "C10orf77; MFSD13A; SLC68A1; TMEM180; bA18I14.8",
        "protein_names_uniprotkb": "Solute carrier family 68 member 1; Major facilitator superfamily domain-containing 13A; Transmembrane protein 180",
        "protein_names_refseq": "major facilitator superfamily domain containing 13A; solute carrier family 68 member 1; transmembrane protein 180",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79847)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;24715725;25892735;28228285;29769354;30537002;31217245;31237042;31615651;31844290;32157095;32357974;32387766;33298915;33768244;33968037;33981976;35051231;35580925;36241641",
        "class_list": "",
        "function": "Integrative Analyses Followed by Functional Characterization Reveal TMEM180 as a Schizophrenia Risk Gene., [RefSeq, PubMed]; May act as a cation symporter., [UniProtKB, PubMed]; The allele G of rs2001389 weakened the binding activity with CTCF, and it was related to the lower expression of a putative antioncogene MFSD13A whose knockdown promoted proliferation of PC cells. By integrating analysis on multiomics data, association studies and functional assays, we proposed that the common variant rs2001389 and the gene MFSD13A might be genetic modifiers of PC tumorigenesis., [RefSeq, PubMed]; Using a homology model of TMEM180, we experimentally determined that the protein has 12 transmembrane domains, and that its N-terminal and C-termini are exposed extracellularly. Moreover, we found that the putative cation-binding site of TMEM180 is conserved among orthologs, and that its position is similar to that of melibiose transporter MelB., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 9781,
        "biomarker_type": "",
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        "disease_count": 0,
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        "secondary_ac_list": "Q6NWM8;Q6NWM9;Q6PEZ7;Q9H679",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q14CX5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16798-1",
        "uniprot_id": [
            {
                "id": "MAON_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16798",
                "type": "external"
            }
        ],
        "mass": 67068.0,
        "length": 604,
        "protein_name": "NADP-dependent malic enzyme, mitochondrial",
        "gene_name": "ME3",
        "organism": "Human",
        "refseq_name": "NADP-dependent malic enzyme, mitochondrial isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001014811",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014811",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ME3",
        "gene_names_refseq": "ME3; NADP-ME",
        "protein_names_uniprotkb": "NADP-dependent malic enzyme, mitochondrial; 1.1.1.40; Malic enzyme 3; NADP-ME",
        "protein_names_refseq": "NADP-dependent malic enzyme, mitochondrial isoform 1; NADP-dependent malic enzyme, mitochondrial; malate dehydrogenase (oxaloacetate-decarboxylating) (NADP(+)); malic enzyme 3, NADP(+)-dependent, mitochondrial; malic enzyme, NADP+-dependent, mitochondrial; mitochondrial NADP(+)-dependent malic enzyme 3; pyruvic-malic carboxylase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10873);  (R-HSA-70268)",
        "pathway_count": 2,
        "publication_count": 47,
        "publication_id_list": "11237011;11276087;11377399;11863375;11945601;12121650;12962632;14596586;15551868;15870898;18351441;18959763;19236308;1931970;1935931;19416979;19679512;1993674;1996957;21156174;22628558;23284632;2440048;24998673;25202825;25575590;25594249;27166188;27317664;29472561;29557506;30315122;31607129;32403431;33064660;33619771;3435492;34357683;36417180;36590518;39212717;4822737;7757881;7818469;8726225;9119391;9705294",
        "class_list": "",
        "function": "ATP inhibition is proposed to be determined by the electrostatic potential involving the positive charge on the side chain of Lys346, [RefSeq, PubMed]; Adaptive and Constitutive Activations of Malic Enzymes Confer Liver Cancer Multilayered Protection Against Reactive Oxygen Species., [RefSeq, PubMed]; Catalyzes the oxidative decarboxylation of (S)-malate to pyruvate using NADP(+), and is able to reverse the reaction but only with significantly lower efficiency (PubMed:7818469). Can also catalyze the decarboxylation of oxaloacetate into pyruvate (By similarity)., [UniProtKB, PubMed, UniProtKB]; Downregulation of malic enzyme 3 facilitates progression of gastric carcinoma via regulating intracellular oxidative stress and hypoxia-inducible factor-1alpha stabilization. Publication Status: Online-Only, [RefSeq, PubMed]; Human c-NADP-ME exists mainly as a tetramer, whereas human m-NAD(P)-ME exists as a mixture of dimers and tetramers, [RefSeq, PubMed]; ME3 is extensively involved in carcinogenesis of pancreatic cancer, [RefSeq, PubMed]; Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]; Studies demonstrate that the Lys57 residue plays dual functional roles in the structural integrity of the allosteric site and in the subunit-subunit interaction at the dimer interface of m-NAD(P)-ME. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "reported_s_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
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        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z6V0;Q8TBJ0",
        "ec_number_list": [
            {
                "id": "1.1.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.38",
                "type": "external"
            },
            {
                "id": "1.1.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.40",
                "type": "external"
            },
            {
                "id": "3.7.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.7.1.5",
                "type": "external"
            },
            {
                "id": "4.1.1.112",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.112",
                "type": "external"
            },
            {
                "id": "5.3.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.2.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008948 oxaloacetate decarboxylase activity;GO:0046872 metal ion binding;GO:0051287 NAD binding;GO:0070401 NADP+ binding;GO:0004470 malic enzyme activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0042866 pyruvate biosynthetic process;GO:0006108 malate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q16798-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WZA0-1",
        "uniprot_id": [
            {
                "id": "LZIC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WZA0",
                "type": "external"
            }
        ],
        "mass": 21495.0,
        "length": 190,
        "protein_name": "Protein LZIC",
        "gene_name": "LZIC",
        "organism": "Human",
        "refseq_name": "protein LZIC isoform a",
        "refseq_ac": [
            {
                "id": "NP_001303902",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001303902",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LZIC",
        "gene_names_refseq": "LZIC",
        "protein_names_uniprotkb": "Protein LZIC; Leucine zipper and CTNNBIP1 domain-containing protein; Leucine zipper and ICAT homologous domain-containing protein",
        "protein_names_refseq": "leucine zipper and CTNNBIP1 domain-containing protein; leucine zipper and ICAT homologous domain-containing protein; leucine zipper domain and ICAT homologous domain containing; protein LZIC isoform a; protein LZIC",
        "tax_id": 9606,
        "disease": "osteosarcoma (Disease Ontology:DOID:3347)",
        "pathway": " (hsa:84328)",
        "pathway_count": 1,
        "publication_count": 30,
        "publication_id_list": "11237011;11712074;19913121;20068231;20628086;26154972;26992070;28218747;28411811;28832583;29493099;29508533;29557506;29786170;30192525;30429286;30973299;31154438;31611695;31844290;31848261;32157095;32350084;32938616;32983136;33912179;34932366;35051231;35251023;35580925",
        "class_list": "",
        "function": "LZIC is functionally involved in cellular response to ionizing radiation, and its expression level could serve as a biomarker for patient stratification in clinical cancer practice., [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
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        "reported_mutagensis": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6F0;B4E2N0;Q96IU1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008013 beta-catenin binding",
        "go_cellular_component": "",
        "go_biological_process": "GO:0010212 response to ionizing radiation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q8WZA0-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60870-1",
        "uniprot_id": [
            {
                "id": "KIN17_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60870",
                "type": "external"
            }
        ],
        "mass": 45374.0,
        "length": 393,
        "protein_name": "DNA/RNA-binding protein KIN17",
        "gene_name": "KIN",
        "organism": "Human",
        "refseq_name": "DNA/RNA-binding protein KIN17",
        "refseq_ac": [
            {
                "id": "NP_036443",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036443",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KIN; BTCD; KIN17",
        "gene_names_refseq": "BTCD; KIN17; KIN; Rts2",
        "protein_names_uniprotkb": "DNA/RNA-binding protein KIN17; Binding to curved DNA; KIN, antigenic determinant of recA protein homolog",
        "protein_names_refseq": "DNA/RNA-binding protein KIN17; KIN, antigenic determinant of recA protein homolog; binding to curved DNA",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22944);  (R-HSA-8876725)",
        "pathway_count": 2,
        "publication_count": 78,
        "publication_id_list": "10964102;11237011;11880372;12359749;12525703;12754299;12853634;15831485;16118227;17045609;18029424;23349634;24129315;24714562;24715725;25144183;25231979;25416781;25576301;25645385;25892735;26154972;26375851;26545399;26728094;26811146;26992070;27600516;27846572;27862975;27920218;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632711;29786170;30429286;30484775;30779550;30833945;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33592498;33912179;33936100;33968037;34171305;34185709;34211107;34417717;34449532;34561969;35051231;35561310;35580925;36010968;36468848;38935235;40307207;9266022",
        "class_list": "",
        "function": "Interactome Analysis of KIN (Kin17) Shows New Functions of This Protein. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in DNA replication and the cellular response to DNA damage. May participate in DNA replication factories and create a bridge between DNA replication and repair mediated by high molecular weight complexes. May play a role in illegitimate recombination and regulation of gene expression. May participate in mRNA processing. Binds, in vitro, to double-stranded DNA. Also shown to bind preferentially to curved DNA in vitro and in vivo (By similarity). Binds via its C-terminal domain to RNA in vitro., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; KIN17 functions in DNA damage repair and chemosensitivity by modulating RAD51 in hepatocellular carcinoma., [RefSeq, PubMed]; KIN17 promotes cell migration and invasion through stimulating the TGF-beta/Smad2 pathway in hepatocellular carcinoma., [RefSeq, PubMed]; The protein encoded by this gene is a nuclear protein that forms intranuclear foci during proliferation and is redistributed in the nucleoplasm during the cell cycle. Short-wave ultraviolet light provokes the relocalization of the protein, suggesting its participation in the cellular response to DNA damage. Originally selected based on protein-binding with RecA antibodies, the mouse protein presents a limited similarity with a functional domain of the bacterial RecA protein, a characteristic shared by this human ortholog. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jan 2012]., [RefSeq]; [1]H, [15]N, and [13]C resonance assignments of the SH3-like tandem domain of human KIN protein., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DX32",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0003690 double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016363 nuclear matrix;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006310 DNA recombination;GO:0006397 mRNA processing;GO:0006260 DNA replication;GO:0006974 DNA damage response",
        "synthesized_glycan_count": 0,
        "hit_score": 8.1,
        "record_id": "O60870-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "LMOD2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P5Q4",
                "type": "external"
            }
        ],
        "mass": 61675.0,
        "length": 547,
        "protein_name": "Leiomodin-2",
        "gene_name": "LMOD2",
        "organism": "Human",
        "refseq_name": "leiomodin-2",
        "refseq_ac": [
            {
                "id": "NP_997046",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997046",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LMOD2",
        "gene_names_refseq": "C-LMOD; CLMOD; CMD2G; LMOD2",
        "protein_names_uniprotkb": "Leiomodin-2; C-LMOD; Cardiac leiomodin; Leiomodin",
        "protein_names_refseq": "cardiac leiomodin; leiomodin 2 (cardiac); leiomodin-2",
        "tax_id": 9606,
        "disease": "dilated cardiomyopathy 2G (Disease Ontology:DOID:0081163); dilated cardiomyopathy (Disease Ontology:DOID:12930)",
        "pathway": " (hsa:442721)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "11237011;11318603;16633140;18403713;20685966;25250574;26370058;26417072;26873245;28834725;29351928;30192525;30379171;31517052;31844290;32938616;33968037;34888509;35051231;35082396;35188328;35318648;36010968;37296576;38748723",
        "class_list": "",
        "function": "Crystal Structure of Leiomodin 2 in Complex with Actin, [RefSeq, PubMed]; Disruption of cardiac thin filament assembly arising from a mutation in LMOD2: A novel mechanism of neonatal dilated cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Human disease-causing mutations result in loss of leiomodin 2 through nonsense-mediated mRNA decay. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates nucleation of actin filaments and thereby promotes actin polymerization (PubMed:18403713, PubMed:25250574, PubMed:26370058, PubMed:26417072). Plays a role in the regulation of actin filament length (By similarity). Required for normal sarcomere organization in the heart, and for normal heart function (PubMed:18403713)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Study describes an actin-binding protein, leiomodin, that acted as a strong filament nucleator in muscle cells, [RefSeq, PubMed]; The mutation reduced binding affinity for both Lmod2 and Tmod1. The effect of the K15N mutation on Tpm1.1 binding to Lmod2 and Tmod1 provides a molecular rationale for the development of familial dilated cardiomyopathies ., [RefSeq, PubMed]; Whole-Exome Sequencing Identifies Homozygote Nonsense Variants in LMOD2 Gene Causing Infantile Dilated Cardiomyopathy. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D0W9;A4D0Y2;Q8WVJ8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0003785 actin monomer binding;GO:0005523 tropomyosin binding",
        "go_cellular_component": "GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0005865 striated muscle thin filament;GO:0030017 sarcomere;GO:0031430 M band",
        "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0030041 actin filament polymerization;GO:0045214 sarcomere organization;GO:0045010 actin nucleation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q6P5Q4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q969Z3-1",
        "uniprot_id": [
            {
                "id": "MARC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q969Z3",
                "type": "external"
            }
        ],
        "mass": 38023.0,
        "length": 335,
        "protein_name": "Mitochondrial amidoxime reducing component 2",
        "gene_name": "MTARC2",
        "organism": "Human",
        "refseq_name": "mitochondrial amidoxime reducing component 2 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001304267",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304267",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MTARC2; MARC2; MOSC2",
        "gene_names_refseq": "MARC2; MOSC2; MTARC2",
        "protein_names_uniprotkb": "Mitochondrial amidoxime reducing component 2; 1.7.-.-; MOSC domain-containing protein 2; Moco sulfurase C-terminal domain-containing protein 2; Molybdenum cofactor sulfurase C-terminal domain-containing protein 2; mARC2",
        "protein_names_refseq": "MOCO sulphurase C-terminal domain containing 2; MOSC domain-containing protein 2, mitochondrial; mitochondrial amidoxime reducing component 2 isoform a precursor; moco sulfurase C-terminal domain-containing protein 2; molybdenum cofactor sulfurase C-terminal domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54996);  (R-HSA-211945)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "10445380;10945627;11154734;11230166;11237011;11422004;12725862;12732646;1351198;15350128;15492766;15523003;15535985;16614850;16765324;17400359;18254726;18256025;18285471;19053771;19588076;19764817;20007405;20177059;20422440;20542992;20808825;20861021;21029045;22700792;22813719;23616950;23953689;24423752;24677340;24900196;25144769;25425164;25446851;25621951;25713076;25923589;26992070;2897122;29557506;29632046;30524438;31530632;31848261;32152082;32171872;32187464;32205870;32210741;32387766;32488085;32938616;38010085;7980644;8985016;9169443;9367528;9653080",
        "class_list": "",
        "function": "Arc1(MOSC-1) and Arc2(MOSC-2) proteins are monomeric in their active forms., [RefSeq, PubMed]; CIRC-MARC2 SILENCING PROTECTS HUMAN CARDIOMYOCYTES FROM HYPOXIA/REOXYGENATION-INDUCED INJURY BY MODULATING MIR-335-5P/TRPM7 AXIS., [RefSeq, PubMed]; Catalyzes the reduction of N-oxygenated molecules, acting as a counterpart of cytochrome P450 and flavin-containing monooxygenases in metabolic cycles (PubMed:21029045, PubMed:24423752). As a component of prodrug-converting system, reduces a multitude of N-hydroxylated prodrugs particularly amidoximes, leading to increased drug bioavailability (PubMed:21029045, PubMed:24423752). May be involved in mitochondrial N(omega)-hydroxy-L-arginine (NOHA) reduction, regulating endogenous nitric oxide levels and biosynthesis (PubMed:21029045). Postulated to cleave the N-OH bond of N-hydroxylated substrates in concert with electron transfer from NADH to cytochrome b5 reductase then to cytochrome b5, the ultimate electron donor that primes the active site for substrate reduction (PubMed:21029045)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; MARC2 has a pivotal role in protecting human cells against apoptotic effects of the base analog N6-hydroxylaminopurine., [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is an enzyme found in the outer mitochondrial membrane that reduces N-hydroxylated substrates. The encoded protein uses molybdenum as a cofactor and cytochrome b5 type B and NADH cytochrome b5 reductase as accessory proteins. One type of substrate used is N-hydroxylated nucleotide base analogues, which can be toxic to a cell. Other substrates include N(omega)-hydroxy-L-arginine (NOHA) and amidoxime prodrugs, which are activated by the encoded enzyme. Multiple transcript variants encoding the different isoforms have been found for this gene. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2D0R5;D3DTB3;Q0JSK7;Q5VT67;Q5VXC7;Q7L317;Q9H066;Q9NWU0",
        "ec_number_list": [
            {
                "id": "1.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2",
                "type": "external"
            },
            {
                "id": "1.7.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0008940 nitrate reductase activity;GO:0030170 pyridoxal phosphate binding;GO:0043546 molybdopterin cofactor binding;GO:0016661 oxidoreductase activity, acting on other nitrogenous compounds as donors",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome",
        "go_biological_process": "GO:0006809 nitric oxide biosynthetic process;GO:0042126 nitrate metabolic process;GO:0051410 detoxification of nitrogen compound;GO:0070458 cellular detoxification of nitrogen compound",
        "synthesized_glycan_count": 0,
        "hit_score": 6.4,
        "record_id": "Q969Z3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q641Q3-1",
        "uniprot_id": [
            {
                "id": "METRL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q641Q3",
                "type": "external"
            }
        ],
        "mass": 34398.0,
        "length": 311,
        "protein_name": "Meteorin-like protein",
        "gene_name": "METRNL",
        "organism": "Human",
        "refseq_name": "meteorin-like protein isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001004431",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004431",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METRNL",
        "gene_names_refseq": "METRNL",
        "protein_names_uniprotkb": "Meteorin-like protein; Subfatin",
        "protein_names_refseq": "cometin; meteorin, glial cell differentiation regulator-like; meteorin-like protein isoform 1 precursor; meteorin-like protein; subfatin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284207)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "10.1038/emboj.2013.79;11237011;23584533;24393292;24906147;26307585;27716826;27748745;30212581;32350084;35251023;36010968;36825397;36877355;38054817;38192243;39056787",
        "class_list": "",
        "function": "Betatrophin, elabela, asprosin, glucagon and subfatin peptides in breast tissue, blood and milk in gestational diabetes., [RefSeq, PubMed]; Data suggest that there is no correlation between serum Metrnl levels and BMI (body mass index) in humans., [RefSeq, PubMed]; Downregulation of METRNL during adipogenesis and functional induction of increased proliferation in stromal vascular fraction cells with concomitant inhibition of adipocyte differentiation may result in hypertrophic AT accumulation, [RefSeq, PubMed]; Hormone induced following exercise or cold exposure that promotes energy expenditure. Induced either in the skeletal muscle after exercise or in adipose tissue following cold exposure and is present in the circulation. Able to stimulate energy expenditure associated with the browning of the white fat depots and improves glucose tolerance. Does not promote an increase in a thermogenic gene program via direct action on adipocytes, but acts by stimulating several immune cell subtypes to enter the adipose tissue and activate their prothermogenic actions. Stimulates an eosinophil-dependent increase in IL4 expression and promotes alternative activation of adipose tissue macrophages, which are required for the increased expression of the thermogenic and anti-inflammatory gene programs in fat. Required for some cold-induced thermogenic responses, suggesting a role in metabolic adaptations to cold temperatures (By similarity)., [UniProtKB]; Is meteorin-like (Metrnl) a novel biomarker to distinguish patients with obstructive sleep apnea (OSA) and patients with OSA at vascular risk., [RefSeq, PubMed]; Lower serum levels of Metrnl in patients with coronary artery disease and type 2 diabetes mellitus are negatively associated with insulin resistance and inflammatory cytokines. Publication Status: Online-Only, [RefSeq, PubMed]; Meteorin-like protein elevation post-exercise improved vascular inflammation among coronary artery disease patients by downregulating NLRP3 inflammasome activity., [RefSeq, PubMed]; Overexpression of METRNL inhibited mineralized nodule formation. Publication Status: Online-Only, [RefSeq, PubMed]; Results show that Subfatin is a novel adipokine regulated by adipogenesis and obesity, with tissue distribution different from its homologue Meteorin, [RefSeq, PubMed]; Role of asprosin and meteorin-like peptide in progression of actinic keratosis to squamous cell carcinoma., [RefSeq, PubMed]; The Novel Cytokine Interleukin-41/Meteorin-like Is Reduced in Diffuse Systemic Sclerosis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KSJ5;Q86VM0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005179 hormone activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0070062 extracellular exosome;GO:0005576 extracellular region",
        "go_biological_process": "GO:0009409 response to cold;GO:0050873 brown fat cell differentiation;GO:0050728 negative regulation of inflammatory response;GO:0097009 energy homeostasis;GO:0045444 fat cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q641Q3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UHR6-1",
        "uniprot_id": [
            {
                "id": "ZNHI2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UHR6",
                "type": "external"
            }
        ],
        "mass": 42884.0,
        "length": 403,
        "protein_name": "Zinc finger HIT domain-containing protein 2",
        "gene_name": "ZNHIT2",
        "organism": "Human",
        "refseq_name": "zinc finger HIT domain-containing protein 2",
        "refseq_ac": [
            {
                "id": "NP_055020",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055020",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZNHIT2; C11orf5",
        "gene_names_refseq": "C11orf5; FON; ZNHIT2",
        "protein_names_uniprotkb": "Zinc finger HIT domain-containing protein 2; Protein FON",
        "protein_names_refseq": "zinc finger HIT domain-containing protein 2; zinc finger, HIT domain containing 2; zinc finger, HIT type 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:741)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "10602999;11237011;16959974;17656577;18669648;18691976;20068231;23186163;23481700;25645385;26992070;28218747;28561026;28832583;28834231;29242379;29437277;29557506;29632711;29769354;29786170;30315122;30410026;30429286;30833945;31217245;31844290;31848261;31937595;32488085;32938616;32983136;33141586;33298915;33717175;33936100;33968037;34171305;34932366;35051231",
        "class_list": "",
        "function": "May act as a bridging factor mediating the interaction between the R2TP/Prefoldin-like (R2TP/PFDL) complex and U5 small nuclear ribonucleoprotein (U5 snRNP) (PubMed:28561026). Required for the interaction of R2TP complex subunit RPAP3 and prefoldin-like subunit URI1 with U5 snRNP proteins EFTUD2 and PRPF8 (PubMed:28561026). May play a role in regulating the composition of the U5 snRNP complex (PubMed:28561026)., [UniProtKB, PubMed]; The interaction between RUVBL1/RUVBL2 and the U5 small nuclear ribonucleoprotein is mostly mediated by the previously uncharacterized factor ZNHIT2. Publication Status: Online-Only, [RefSeq, PubMed]; The unique three-dimensional structure of the zinc finger HIT domain revealed a novel zinc-binding fold, as a new member of the treble clef domain family, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3SY14;Q8IUV0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q9UHR6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13495-1",
        "uniprot_id": [
            {
                "id": "MAMD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13495",
                "type": "external"
            }
        ],
        "mass": 83231.0,
        "length": 774,
        "protein_name": "Mastermind-like domain-containing protein 1",
        "gene_name": "MAMLD1",
        "organism": "Human",
        "refseq_name": "mastermind-like domain-containing protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001170936",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170936",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAMLD1; CG1; CXorf6",
        "gene_names_refseq": "CG1; CXorf6; F18; HYSP2; MAMLD1",
        "protein_names_uniprotkb": "Mastermind-like domain-containing protein 1; F18; Protein CG1",
        "protein_names_refseq": "mastermind-like domain-containing protein 1 isoform 1; mastermind-like domain-containing protein 1",
        "tax_id": 9606,
        "disease": "hypospadias (Disease Ontology:DOID:10892)",
        "pathway": " (hsa:10046);  (R-HSA-1912408);  (R-HSA-210744);  (R-HSA-2122947);  (R-HSA-2197563);  (R-HSA-2644606);  (R-HSA-2894862);  (R-HSA-350054);  (R-HSA-8941856);  (R-HSA-9013508);  (R-HSA-9013695);  (R-HSA-9793380);  (R-HSA-9976102)",
        "pathway_count": 13,
        "publication_count": 145,
        "publication_id_list": "10206645;10713164;10879540;10882063;10964718;11006133;11044625;11101851;11112321;11237011;11461910;11585921;11740940;11866432;11986231;12050117;12209127;12354787;12374742;12386158;12391150;12530964;14672936;14980219;14991602;15107403;15472075;15531924;15546612;15574878;15684396;15760269;15824097;15829515;16093323;16256737;16530044;16530045;16612405;16738328;16751179;17003037;17086185;17114293;17157496;17284587;17344417;17401372;17540598;17540599;17554337;17646408;17646409;17685488;17823410;18043734;18077452;18094723;18162467;18239137;18296446;1831692;18374649;18724371;18824583;18824585;18974129;19150886;19151708;19524514;19714243;19723635;19726682;19773441;19800882;20068231;20080834;20090754;20351093;20442293;20442780;20495621;20801121;20804727;20805998;20972443;21280156;21402699;21551231;21602795;21637926;21875955;22110129;22396495;23186163;25417103;26387946;26801977;26977885;27749937;27841855;28178531;28904123;29101237;29146722;29557506;30059200;30620550;31154438;31492838;31844290;32161166;32387766;32938616;33392160;33424767;33968037;34487543;34517852;34695834;35051231;35289036;36898841;38665916;39302247;39531497;40136647;7566092;7588063;8001118;8640223;8649374;8687460;8789451;8878478;9169146;9244301;9315665;9462510;9604939;9620803;9651681;9693032;9694793;9819428",
        "class_list": "",
        "function": "Deletion of the F18 (MAMLD1) and MTM1 genes in two patients with congenital myopathy and hypospadias, [RefSeq, PubMed]; Disorders of Sex Development in Individuals Harbouring MAMLD1 Variants: WES and Interactome Evidence of Oligogenic Inheritance. Publication Status: Online-Only, [RefSeq, PubMed]; Identified three different nonsense mutations of CXorf6 in individuals with hypospadias Erratum:[Nat Genet. 2007 Jan;39(1):131. Nordenskjold, Agneta [added]], [RefSeq, PubMed]; MAMLD1 and Differences/Disorders of Sex Development: An Update. Review article, [RefSeq, PubMed]; Pathogenic variations in MAML2 and MAMLD1 contribute to congenital hypothyroidism due to dyshormonogenesis by regulating the Notch signalling pathway., [RefSeq, PubMed]; The genomic profiling and MAMLD1 expression in human and canines with Cushing's disease. Publication Status: Online-Only, [RefSeq, PubMed]; The identification and genomic characterization of the F18 (MAMLD1) gene in human, [RefSeq, PubMed]; This gene encodes a mastermind-like domain containing protein. This protein may function as a transcriptional co-activator. Mutations in this gene are the cause of X-linked hypospadias type 2. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]., [RefSeq]; Transactivates the HES3 promoter independently of NOTCH proteins. HES3 is a non-canonical NOTCH target gene which lacks binding sites for RBPJ., [UniProtKB, PubMed]; [Advance in research on the role of MAMLD1 gene in disorders of sex development]. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 14,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 14,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 14,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 17,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCQ4;B4DG93;B9EGA5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016604 nuclear body",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008584 male gonad development",
        "synthesized_glycan_count": 0,
        "hit_score": 16.1,
        "record_id": "Q13495-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NQ48-1",
        "uniprot_id": [
            {
                "id": "LZTL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NQ48",
                "type": "external"
            }
        ],
        "mass": 34592.0,
        "length": 299,
        "protein_name": "Leucine zipper transcription factor-like protein 1",
        "gene_name": "LZTFL1",
        "organism": "Human",
        "refseq_name": "leucine zipper transcription factor-like protein 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001263307",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263307",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LZTFL1",
        "gene_names_refseq": "BBS17; LZTFL1",
        "protein_names_uniprotkb": "Leucine zipper transcription factor-like protein 1",
        "protein_names_refseq": "leucine zipper transcription factor-like protein 1 isoform 2; leucine zipper transcription factor-like protein 1",
        "tax_id": 9606,
        "disease": "Bardet-Biedl syndrome 17 (Disease Ontology:DOID:0110139)",
        "pathway": " (hsa:54585);  (R-HSA-5620922)",
        "pathway_count": 2,
        "publication_count": 41,
        "publication_id_list": "11237011;11252952;11352561;15258860;15314642;17574030;19081074;19421068;19575670;20080638;20233871;20237496;20603001;21427764;22072986;22139371;22389062;22500027;22510444;23351793;23692385;24296415;25443296;25446516;25576301;26992070;27846572;29393594;31844290;32157095;32350084;32938616;33968037;34998241;35494241;35753602;36215666;36241641;36284347;36966254;37578643",
        "class_list": "",
        "function": "Association of 3p21.31 Locus (CXCR6 and LZTFL1) with COVID-19 Outcomes in Brazilian Hospitalyzed Subjects. Publication Status: Online-Only, [RefSeq, PubMed]; CRISPRi links COVID-19 GWAS loci to LZTFL1 and RAVER1., [RefSeq, PubMed]; Host genetic loci LZTFL1 and CCL2 associated with SARS-CoV-2 infection and severity of COVID-19., [RefSeq, PubMed]; LZTFL1 inhibits kidney tumor cell growth by destabilizing AKT through ZNRF1-mediated ubiquitin proteosome pathway., [RefSeq, PubMed]; LZTFL1 may inhibit tumorigenesis by stabilizing E-cadherin-mediated adherens junction formation and promoting epithelial cell differentiation., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Our findings suggest that LZTFL1 is an important regulator of BBSome ciliary trafficking and hedgehog signaling, [RefSeq, PubMed]; Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a ubiquitously expressed protein that localizes to the cytoplasm. This protein interacts with Bardet-Biedl Syndrome (BBS) proteins and, through its interaction with BBS protein complexes, regulates protein trafficking to the ciliary membrane. Nonsense mutations in this gene cause a form of Bardet-Biedl Syndrome; a ciliopathy characterized in part by polydactyly, obesity, cognitive impairment, hypogonadism, and kidney failure. This gene may also function as a tumor suppressor; possibly by interacting with E-cadherin and the actin cytoskeleton and thereby regulating the transition of epithelial cells to mesenchymal cells. [provided by RefSeq, Aug 2020]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_o_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KSI9;B4E0K7;Q8TC61;Q9NQ56",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005929 cilium;GO:0002177 manchette",
        "go_biological_process": "GO:0030317 flagellated sperm motility;GO:1903565 negative regulation of protein localization to cilium;GO:1903568 negative regulation of protein localization to ciliary membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q9NQ48-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IWC1-1",
        "uniprot_id": [
            {
                "id": "MA7D3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IWC1",
                "type": "external"
            }
        ],
        "mass": 98429.0,
        "length": 876,
        "protein_name": "MAP7 domain-containing protein 3",
        "gene_name": "MAP7D3",
        "organism": "Human",
        "refseq_name": "MAP7 domain-containing protein 3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001166987",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166987",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAP7D3; MDP3",
        "gene_names_refseq": "MAP7D3; MDP3",
        "protein_names_uniprotkb": "MAP7 domain-containing protein 3",
        "protein_names_refseq": "MAP7 domain-containing protein 3 isoform 2; MAP7 domain-containing protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79649)",
        "pathway_count": 1,
        "publication_count": 69,
        "publication_id_list": "11237011;15561729;17287340;17697703;18452278;18669648;19007248;19413330;19651622;19664995;19691289;20068231;22142902;23186163;23301498;24366607;24614595;24715725;24927501;25161703;25576301;25802875;26154972;26506222;26992070;27284004;27600516;27846572;27920218;28063628;28218747;28832583;28904123;29242379;29508533;29557506;30315122;30379171;30429286;30524438;30770434;31217245;31844290;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33592498;33912179;33968037;33981976;34087483;34171305;34561969;34932366;35051231;35318648;35580925;36010968;36215666;36284347;37938771;39302247;40136647",
        "class_list": "",
        "function": "A critical role for Mdp3 in the growth and metastasis of breast cancer. Erratum:[Theranostics. 2020 Apr 12;10(12):5527. doi: 10.7150/thno.45566. PMID: 32373226] Publication Status: Online-Only, [RefSeq, PubMed]; MAP7 proteins are microtubule-tethered kinesin-1 activators, with which the motor transiently interacts as it moves along microtubules., [RefSeq, PubMed]; Mdp3 (also known as MAP7D3) forms a complex with DDA3 (also known as PSRC1) and controls spindle dynamics at the minus end of Microtubuless by inhibiting DDA3-mediated Kif2a recruitment to the spindle., [RefSeq, PubMed]; Mdp3 is a novel microtubule-binding protein that regulates microtubule assembly and stability., [RefSeq, PubMed]; Promotes the assembly and stability of microtubules., [UniProtKB, PubMed, PubMed]; Results have identified a new microtubule binding region in MAP7D3, formed by the conserved MAP7 domain and the C-terminal tail, which can bind to microtubules and promote their assembly and stability. Publication Status: Online-Only, [RefSeq, PubMed]; The amino-terminal region mediated the interaction of Mdp3 with histone deacetylase 6 (HDAC6), in addition to its association with tubulin and microtubules. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to the MAP7 (microtubule-associated protein 7) family. Alternatively spliced transcript variants encoding different isoforms have been found. [provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A2J0;A6NCZ7;A6NHR4;B4DWD2;H7BY77;Q5JXI5;Q5JXI6;Q6P2S1;Q9H9M8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008017 microtubule binding;GO:0015631 tubulin binding",
        "go_cellular_component": "GO:0005819 spindle;GO:0016020 membrane;GO:0015630 microtubule cytoskeleton",
        "go_biological_process": "GO:0046785 microtubule polymerization;GO:0000226 microtubule cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q8IWC1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5TIA1-1",
        "uniprot_id": [
            {
                "id": "MEI1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5TIA1",
                "type": "external"
            }
        ],
        "mass": 141161.0,
        "length": 1274,
        "protein_name": "Meiosis inhibitor protein 1",
        "gene_name": "MEI1",
        "organism": "Human",
        "refseq_name": "meiosis inhibitor protein 1",
        "refseq_ac": [
            {
                "id": "NP_689726",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689726",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MEI1",
        "gene_names_refseq": "HYDM3; MEI1; SPATA38",
        "protein_names_uniprotkb": "Meiosis inhibitor protein 1; Meiosis defective protein 1",
        "protein_names_refseq": "meiosis defective 1; meiosis defective protein 1; meiosis inhibitor 1; meiosis inhibitor protein 1; spermatogenesis associated 38",
        "tax_id": 9606,
        "disease": "gestational trophoblastic neoplasm (Disease Ontology:DOID:3590); hydatidiform mole, recurrent, 3 (MONDO:MONDO:0032746)",
        "pathway": " (hsa:150365)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "11237011;16683055;18477386;28218747;28718531;29437277;29557506;29659827;30379171;30388401;30410026;31844290;32357974;32387766;32741963;33912179;34037756;34509645;35051231;35580925;36010968;36241641;36759719;38416203",
        "class_list": "",
        "function": "Bi-allelic MEI1 variants cause meiosis arrest and non-obstructive azoospermia., [RefSeq, PubMed]; MEI1 may play a role in meiosis during spermatogenesis, especially in European Americans., [RefSeq, PubMed]; Novel MEI1 mutations cause chromosomal and DNA methylation abnormalities leading to embryonic arrest and implantation failure. Publication Status: Online-Only, [RefSeq, PubMed]; Novel biallelic mutations in MEI1: expanding the phenotypic spectrum to human embryonic arrest and recurrent implantation failure., [RefSeq, PubMed]; Required for normal meiotic chromosome synapsis. May be involved in the formation of meiotic double-strand breaks (DSBs) in spermatocytes (By similarity)., [UniProtKB, UniProtKB]; We report on a homozygous missense mutation in the gene coding for meiotic double-stranded break formation protein 1 observed in two brothers with non-obstructive azoospermia and meiotic arrest. A fertile brother was heterozygous for the mutation. All the queried databases predicted that this mutation is damaging, and it has previously been reported that Mei1 knock-out is associated with meiotic arrest in a murine model., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z745;Q1XAP1;Q1XAP2;Q8IYJ5;Q8N5K5;Q8N9H3;Q8TC68",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0007127 meiosis I",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q5TIA1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BYQ8-1",
        "uniprot_id": [
            {
                "id": "KRA49_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BYQ8",
                "type": "external"
            }
        ],
        "mass": 22405.0,
        "length": 210,
        "protein_name": "Keratin-associated protein 4-9",
        "gene_name": "KRTAP4-9",
        "organism": "Human",
        "refseq_name": "keratin-associated protein 4-9",
        "refseq_ac": [
            {
                "id": "NP_001139513",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139513",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KRTAP4-9; KAP4.9; KRTAP4.9",
        "gene_names_refseq": "KAP4.9; KRTAP4-9",
        "protein_names_uniprotkb": "Keratin-associated protein 4-9; Keratin-associated protein 4.9; Ultrahigh sulfur keratin-associated protein 4.9",
        "protein_names_refseq": "keratin-associated protein 4-9; keratin-associated protein 4.9; ultrahigh sulfur keratin-associated protein 4.9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100132386);  (R-HSA-6805567)",
        "pathway_count": 2,
        "publication_count": 12,
        "publication_id_list": "11279113;15373777;15955084;16382671;1691188;1694855;1714783;17521629;23481192;2414304;25208914;9468612",
        "class_list": "",
        "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "predicted_c_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0045095 keratin filament",
        "go_biological_process": "GO:0042633 hair cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9BYQ8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P16150-1",
        "uniprot_id": [
            {
                "id": "LEUK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P16150",
                "type": "external"
            }
        ],
        "mass": 40322.0,
        "length": 400,
        "protein_name": "Leukosialin",
        "gene_name": "SPN",
        "organism": "Human",
        "refseq_name": "leukosialin precursor",
        "refseq_ac": [
            {
                "id": "NP_001025459",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025459",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SPN; CD43",
        "gene_names_refseq": "CD43; GALGP; GPL115; LEU-22; LSN; SPN",
        "protein_names_uniprotkb": "Leukosialin; GALGP; GPL115; Galactoglycoprotein; Leukocyte sialoglycoprotein; Sialophorin",
        "protein_names_refseq": "galactoglycoprotein; leukocyte sialoglycoprotein; leukosialin precursor; sialophorin (gpL115, leukosialin, CD43)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6693);  (R-HSA-202733);  (R-HSA-210991)",
        "pathway_count": 3,
        "publication_count": 139,
        "publication_id_list": "10.1038/emboj.2013.79;10606205;10764623;10880960;10921872;11207550;11237011;11256994;11564780;11719518;11779189;11812992;11943775;12070135;12208882;12469115;12558975;12782713;14529530;14615387;14707126;15000751;15003504;15528364;15540986;15681301;15721307;15901826;1591491;15946952;16258728;16260747;16297198;16585556;16691243;16737840;16783819;17064312;17099249;17116209;17167768;17172599;1731338;17322099;17379836;17442946;17452516;17505016;17525755;17563375;17580308;17600130;17615384;17625065;17996943;18036228;18088087;1827122;18586676;1872812;19279206;19367720;19651622;19690332;20058876;20166139;2033371;21193412;21659548;2241892;23186163;23584533;23945545;24043627;24328034;24714562;24764293;2521952;2530225;2538457;25502872;25548167;25576301;26728094;26811146;2784859;28218747;28832583;28855257;28904123;29242379;29314611;29351928;29393594;2943741;29508533;29557506;2971663;30459171;31020640;31154438;31217245;31611695;31844290;31998317;32157095;32265295;32350084;32502341;32983136;33043033;33249940;33392160;33533043;33640457;34357683;34433824;34932366;35051231;35154160;35251023;35494241;3711098;40307207;468991;6725284;7509040;7521878;8163559;8166770;8314844;9052782;9169774;9242610;9295288;9360995;9382878;9693095;9763524",
        "class_list": "",
        "function": "CD43 (sialophorin) is involved in the induction of extracellular matrix remodeling and angiogenesis by lung cancer cells., [RefSeq, PubMed]; CD43 in the malignant flow cytometry laboratory in 2020., [RefSeq, PubMed]; Identification and functional characterization of a Siglec-7 counter-receptor on K562 cells., [RefSeq, PubMed]; Predominant cell surface sialoprotein of leukocytes which regulates multiple T-cell functions, including T-cell activation, proliferation, differentiation, trafficking and migration. Positively regulates T-cell trafficking to lymph-nodes via its association with ERM proteins (EZR, RDX and MSN) (By similarity). Negatively regulates Th2 cell differentiation and predisposes the differentiation of T-cells towards a Th1 lineage commitment. Promotes the expression of IFN-gamma by T-cells during T-cell receptor (TCR) activation of naive cells and induces the expression of IFN-gamma by CD4(+) T-cells and to a lesser extent by CD8(+) T-cells (PubMed:18036228). Plays a role in preparing T-cells for cytokine sensing and differentiation into effector cells by inducing the expression of cytokine receptors IFNGR and IL4R, promoting IFNGR and IL4R signaling and by mediating the clustering of IFNGR with TCR (PubMed:24328034). Acts as a major E-selectin ligand responsible for Th17 cell rolling on activated vasculature and recruitment during inflammation. Mediates Th17 cells, but not Th1 cells, adhesion to E-selectin. Acts as a T-cell counter-receptor for SIGLEC1 (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Protects cells from apoptotic signals, promoting cell survival., [UniProtKB, UniProtKB]; This gene encodes a highly sialylated glycoprotein that functions in antigen-specific activation of T cells, and is found on the surface of thymocytes, T lymphocytes, monocytes, granulocytes, and some B lymphocytes. It contains a mucin-like extracellular domain, a transmembrane region and a carboxy-terminal intracellular region. The extracellular domain has a high proportion of serine and threonine residues, allowing extensive O-glycosylation, and has one potential N-glycosylation site, while the carboxy-terminal region has potential phosphorylation sites that may mediate transduction of activation signals. Different glycoforms of this protein have been described. In stimulated immune cells, proteolytic cleavage of the extracellular domain occurs in some cell types, releasing a soluble extracellular fragment. Defects in expression of this gene are associated with Wiskott-Aldrich syndrome. [provided by RefSeq, Sep 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 25,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 34,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 34,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 34,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 9,
        "reported_phosphosites": 7,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 46,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 16,
        "disease_count": 0,
        "glyco_site_count": 35,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9B1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0031072 heat shock protein binding;GO:0030544 Hsp70 protein binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0002296 T-helper 1 cell lineage commitment;GO:0006935 chemotaxis;GO:0006955 immune response;GO:0007162 negative regulation of cell adhesion;GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 19.1,
        "record_id": "P16150-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H2X8-1",
        "uniprot_id": [
            {
                "id": "I27L2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H2X8",
                "type": "external"
            }
        ],
        "mass": 12410.0,
        "length": 130,
        "protein_name": "Interferon alpha-inducible protein 27-like protein 2",
        "gene_name": "IFI27L2",
        "organism": "Human",
        "refseq_name": "interferon alpha-inducible protein 27-like protein 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_114425",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_114425",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFI27L2; FAM14A; TLH29",
        "gene_names_refseq": "FAM14A; IFI27L2; ISG12B; TLH29",
        "protein_names_uniprotkb": "Interferon alpha-inducible protein 27-like protein 2; ISG12(b); ISG12B; Interferon-stimulated gene 12b protein; Protein TLH29; pIFI27-like protein",
        "protein_names_refseq": "ISG12(b) protein; family with sequence similarity 14, member A; interferon alpha-inducible protein 27-like protein 2 precursor; interferon alpha-inducible protein 27-like protein 2; interferon-stimulated gene 12b protein; pIFI27-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83982)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;14728724;24715725;25576301;27673746;27777077;27846572;28832583;29242379;29786170;30192525;30429286;31154438;31217245;31844290;31937595;32387766;32983136;33141586;35051231;35561310;35580925;36010968",
        "class_list": "",
        "function": "Plays a role in the apoptotic process and has a pro-apoptotic activity., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8TBD7;Q9NYL0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0031966 mitochondrial membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006915 apoptotic process;GO:0097193 intrinsic apoptotic signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q9H2X8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96QI5-1",
        "uniprot_id": [
            {
                "id": "HS3S6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96QI5",
                "type": "external"
            }
        ],
        "mass": 37186.0,
        "length": 342,
        "protein_name": "Heparan sulfate glucosamine 3-O-sulfotransferase 6",
        "gene_name": "HS3ST6",
        "organism": "Human",
        "refseq_name": "heparan sulfate glucosamine 3-O-sulfotransferase 6",
        "refseq_ac": [
            {
                "id": "NP_001009606",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009606",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HS3ST6; HS3ST5",
        "gene_names_refseq": "3-OST-6; 3OST6; HAE8; HS3ST5; HS3ST6",
        "protein_names_uniprotkb": "Heparan sulfate glucosamine 3-O-sulfotransferase 6; 2.8.2.23; 3-OST-6; Heparan sulfate 3-O-sulfotransferase 6; Heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6; h3-OST-6",
        "protein_names_refseq": "heparan sulfate (glucosamine) 3-O-sulfotransferase 5; heparan sulfate (glucosamine) 3-O-sulfotransferase 6; heparan sulfate D-glucosaminyl 3-O-sulfotransferase 6; heparan sulfate glucosamine 3-O-sulfotransferase 6; heparan sulphate D-glucosaminyl 3-O-sulfotransferase-3B like",
        "tax_id": 9606,
        "disease": "hereditary angioedema (Disease Ontology:DOID:14735); angioedema, hereditary, 8 (MONDO:MONDO:0030298)",
        "pathway": " (hsa:64711);  (R-HSA-2022928)",
        "pathway_count": 2,
        "publication_count": 34,
        "publication_id_list": "10318803;10639137;10644753;10677367;10716625;11087757;11169766;11274177;11279150;11390981;12138164;12492399;15082721;15303968;15607426;16343444;20554947;21700882;23481700;28132690;28148688;29557506;29632046;30471091;33159882;33508266;35051231;35676258;7601448;9346953;9463333;9535912;9915799;9988767",
        "class_list": "glycogene",
        "function": "(Microbial infection) Acts as a binding receptor to Herpes simplex virus-1 (HSV-1) and permits its entry., [UniProtKB, PubMed]; Generates both an antithrombin-binding site and an entry receptor for herpes simplex virus, type 1, [RefSeq, PubMed]; Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) to catalyze the transfer of a sulfo group to heparan sulfate. The substrate-specific O-sulfation generates an enzyme-modified heparan sulfate which Unlike 3-OST-1, does not convert non-anticoagulant heparan sulfate to anticoagulant heparan sulfate., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 529,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96RX7",
        "ec_number_list": [
            {
                "id": "2.8.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.23",
                "type": "external"
            },
            {
                "id": "2.8.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.-",
                "type": "external"
            },
            {
                "id": "2.8.2.29",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.29",
                "type": "external"
            },
            {
                "id": "2.8.2.30",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.2.30",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008467 [heparan sulfate]-glucosamine 3-sulfotransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane",
        "go_biological_process": "GO:0015012 heparan sulfate proteoglycan biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q96QI5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NWW9-1",
        "uniprot_id": [
            {
                "id": "PLAT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NWW9",
                "type": "external"
            }
        ],
        "mass": 17394.0,
        "length": 162,
        "protein_name": "Phospholipase A and acyltransferase 2",
        "gene_name": "PLAAT2",
        "organism": "Human",
        "refseq_name": "phospholipase A and acyltransferase 2",
        "refseq_ac": [
            {
                "id": "NP_060348",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060348",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PLAAT2; HRASLS2",
        "gene_names_refseq": "HRASLS2; PLA1/2-2; PLAAT-2; PLAAT2",
        "protein_names_uniprotkb": "Phospholipase A and acyltransferase 2; 2.3.1.-; 3.1.1.32; 3.1.1.4; HRAS-like suppressor 2",
        "protein_names_refseq": "HRAS like suppressor 2; phospholipase A and acyltransferase 2; phospholipase A/acyltransferase-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54979);  (R-HSA-1482839)",
        "pathway_count": 2,
        "publication_count": 48,
        "publication_id_list": "10092647;10336645;10455175;10681567;11031251;11112443;11830583;12161451;12359733;12522102;15695510;15863501;15944408;16617059;16818490;18163183;18195019;18287005;18458083;18614531;18772128;18781350;19019078;19351971;19501189;19615464;20705608;22605381;22825852;24029068;25802875;26375851;26503625;27920218;28228285;28904123;2925608;2925633;29557506;30315122;31154438;31844290;33912179;35580925;7060561;8300559;9188469;9417066",
        "class_list": "",
        "function": "Data show that acyl-modified forms of HRAS-like tumor suppressors HRASLS2 and HRASLS3 mimicking lipolytic activity of lecithin retinol acyltransferase LRAT., [RefSeq, PubMed]; Exhibits both phospholipase A1/2 and acyltransferase activities (PubMed:19615464, PubMed:22605381, PubMed:22825852, PubMed:26503625). Shows phospholipase A1 (PLA1) and A2 (PLA2) activity, catalyzing the calcium-independent release of fatty acids from the sn-1 or sn-2 position of glycerophospholipids (PubMed:19615464, PubMed:22605381, PubMed:22825852). For most substrates, PLA1 activity is much higher than PLA2 activity (PubMed:19615464). Shows O-acyltransferase activity, catalyzing the transfer of a fatty acyl group from glycerophospholipid to the hydroxyl group of lysophospholipid (PubMed:19615464). Shows N-acyltransferase activity, catalyzing the calcium-independent transfer of a fatty acyl group at the sn-1 position of phosphatidylcholine (PC) and other glycerophospholipids to the primary amine of phosphatidylethanolamine (PE), forming N-acylphosphatidylethanolamine (NAPE), which serves as precursor for N-acylethanolamines (NAEs) (PubMed:19615464, PubMed:22605381, PubMed:22825852). Catalyzes N-acylation of PE using both sn-1 and sn-2 palmitoyl groups of PC as acyl donor (PubMed:22605381). Exhibits high phospholipase A1/2 activity and low N-acyltransferase activity (PubMed:22825852)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; HRASLS2 protein suppressed growth and RAS activities of cancer cells, and the C-terminal hydrophobic domain appeared to be indispensable for both activities., [RefSeq, PubMed]; The protein encoded by this gene has both phospholipase and acyltransferase activities and acts as a tumor suppressor. The encoded protein can hydrolyze dipalmitoylated phosphatidylcholine (PC) to palmitic acid and lyso-PC. In addition, this protein can catalyze the N-acylation of phosphatidylethanolamine and can catalyze the O-acylation of lyso-PC to form PC. [provided by RefSeq, Jul 2016]., [RefSeq]; The tumor suppressors TIG3, HRASLS2 and H-rev107 are involved in the phospholipid metabolism with different physiological roles., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9A7L8",
        "ec_number_list": [
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.2.2",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
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        "publication_id_list": "11230166;19608861;24714562;25576301;25645385;26728094;26992070;27067600;27920218;28190768;28228285;28832583;29242379;29331515;29480802;29557506;29954836;30257210;30379171;30410026;30429286;31530632;31844290;31848261;32028527;32157095;32357974;32502341;32938616;32939087;32983136;33141820;33186521;33589610;33592498;33683197;33717175;33912179;33968037;34087483;34108479;34185709;34210965;34486521;34625544;34732825;34795260;34874266;34932366;35580925;36010968;37541786;37938771;39162207;40596516;40914422",
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        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0019814 immunoglobulin complex",
        "go_biological_process": "GO:0006955 immune response;GO:0002250 adaptive immune response",
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        "record_id": "A0A0C4DH73-1",
        "record_type": "protein",
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    {
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        "uniprot_id": [
            {
                "id": "LCE6A_HUMAN",
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                "type": "external"
            }
        ],
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        "length": 80,
        "protein_name": "Late cornified envelope protein 6A",
        "gene_name": "LCE6A",
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        "refseq_name": "late cornified envelope protein 6A",
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            {
                "id": "NP_001122072",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122072",
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            }
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        "gene_names_refseq": "C1orf44; LCE6A",
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        "protein_names_refseq": "late cornified envelope protein 6A",
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        "pathway": " (hsa:448835);  (R-HSA-6809371)",
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        "class_list": "",
        "function": "Describes neighboring LCE family members that are present in the same cluster on chromosome 1q21., [RefSeq, PubMed]; Precursors of the cornified envelope of the stratum corneum., [UniProtKB]",
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        "uniprot_canonical_ac": "A2NJV5-1",
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            {
                "id": "KV229_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A2NJV5",
                "type": "external"
            }
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        "length": 120,
        "protein_name": "Immunoglobulin kappa variable 2-29",
        "gene_name": "IGKV2-29",
        "organism": "Human",
        "refseq_name": "",
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        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin kappa variable 2-29",
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        "class_list": "immunoglobin",
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        "protein_name": "Killin",
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        "function": "19 of 20 advanced RCC showed somatic hypermethylation upstream of KILLIN, [RefSeq, PubMed]; Cowden syndrome patients have elevated risks of papillary thyroid cancer from KLLN alterations., [RefSeq, PubMed]; DNA-binding protein involved in S phase checkpoint control-coupled apoptosis by mediating p53/TP53-induced apoptosis. Has the ability to inhibit DNA synthesis and S phase arrest coupled to apoptosis. Has affinity to both double- and single-stranded DNA., [UniProtKB, PubMed]; EBF2 Links KMT2D-Mediated H3K4me1 to Suppress Pancreatic Cancer Progression via Upregulating KLLN., [RefSeq, PubMed]; Germline KILLIN methylation is common among patients with Cowden syndrome or Cowden-like syndrome and is associated with increased risks of breast and renal cancer over PTEN mutation-positive individuals, [RefSeq, PubMed]; MiR-744-3p regulates the proliferation and differentiation of keratinocytes through targeting KLLN in psoriasis, [RefSeq, PubMed]; New evidence on tumor suppressor activity of PTEN and KLLN in papillary thyroid carcinoma., [RefSeq, PubMed]; Pathogenic mutations in KLLN are rare in breast cancer families and the c.339_340delAG variant does not represent a high-penetrance breast cancer risk allele., [RefSeq, PubMed]; Results support Killin as a missing link between p53 activation and S phase checkpoint control designed to eliminate replicating precancerous cells, should they escape G(1) blockade mediated by p21. GeneRIF: Killin is a p53-regulated nuclear inhibitor of DNA synthesis with high affinity of DNA binding., [RefSeq, PubMed]; The protein encoded by this intronless gene is found in the nucleus, where it can inhibit DNA synthesis and promote S phase arrest coupled to apoptosis. The expression of this DNA binding protein is upregulated by transcription factor p53. [provided by RefSeq, Dec 2012]., [RefSeq]",
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        "protein_names_refseq": "S-LAM beta; S-laminin subunit beta; laminin B1s chain; laminin S; laminin subunit beta-2 precursor; laminin, beta 2 (laminin S)",
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        "disease": "Pierson syndrome (Disease Ontology:DOID:0060852); nephrotic syndrome type 5 (Disease Ontology:DOID:0080380); primary open angle glaucoma (Disease Ontology:DOID:1070); nephrosis (Disease Ontology:DOID:2527); proteinuria (Disease Ontology:DOID:576)",
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        "publication_count": 222,
        "publication_id_list": "10.1101/2023.09.13.557529;10022829;10026136;10077652;10189375;10218588;10339611;10441321;10512690;10521801;10545507;10614670;10673326;10681634;10810289;10893187;10898936;10912521;10932245;10942431;10951195;10990447;11054877;11084047;11158056;11237011;11250653;11259413;11264294;11316783;11352924;11430802;11495720;11522292;11606061;11739083;11739641;11751371;11788658;11847221;11964076;12189167;12225811;12237301;12241545;12379487;12466191;12810533;12904166;1319059;1370451;1376317;1383255;14715956;15075323;15126567;15175026;15296743;15308688;15367484;1544908;15469690;15485880;15525596;15642270;16293224;16413178;16493581;16524571;16581764;16782899;16806867;16912710;17047378;17249697;17312271;17574028;17588949;17905726;17985932;18764929;19159218;19346169;19946898;20044576;2059554;20798252;20802513;21236492;21642437;21789315;22134916;22159078;22223806;22493504;23090970;23481700;23595123;2364322;2412224;24190977;2420006;2430969;24480479;2476804;2479552;25576301;26091039;26992070;27862975;28657654;29242379;29393594;29557506;29741879;29786170;29789417;30410026;30429286;30459171;30484775;30833945;31154438;31611695;31844290;31848261;32157095;32161166;32350084;32488085;3282674;32938616;32983136;33392160;33554690;33592498;33749661;33968037;33981976;34019948;34087483;34171305;35051231;35251023;35289036;35318648;35580925;36010968;36215666;36284347;37074911;37678612;37938771;38665916;38723581;3997977;6193777;6439184;7499434;7509446;7519608;7523391;7525263;7525634;7525824;7527058;7527330;7527495;7538844;7542669;7543116;7547961;7559467;7588299;7592992;7683646;7685013;7689487;7693733;7698745;7795887;7844150;7852349;7925941;8002934;8043271;8054685;8268918;8349731;8440685;8576247;8607994;8627307;8781553;8798547;8798654;8817670;8845841;8894645;8943283;8964575;9214383;9245798;9252349;9294172;9341124;9346959;9405466;9412493;9417118;9497324;9645947;9652404;9659899;9659900;9685393;9709957;9733769;9786878;9864373;9922210;9949188",
        "class_list": "",
        "function": "Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components., [UniProtKB]; Development of neovascular glaucoma after intraocular surgery in Pierson syndrome., [RefSeq, PubMed]; Early-Onset Myopia and Retinal Detachment without Typical Microcoria or Severe Proteinuria due to a Novel LAMB2 Variant., [RefSeq, PubMed]; Expanding the spectrum of LAMB2: Pierson syndrome associated with neuromuscular junction disorder in two patients., [RefSeq, PubMed]; Laminin beta2 variants associated with isolated nephropathy that impact matrix regulation. Publication Status: Online-Only, [RefSeq, PubMed]; Laminins, a family of extracellular matrix glycoproteins, are the major noncollagenous constituent of basement membranes. They have been implicated in a wide variety of biological processes including cell adhesion, differentiation, migration, signaling, neurite outgrowth and metastasis. Laminins, composed of 3 non identical chains: laminin alpha, beta and gamma (formerly A, B1, and B2, respectively), form a cruciform structure consisting of 3 short arms, each formed by a different chain, and a long arm composed of all 3 chains. Each laminin chain is a multidomain protein encoded by a distinct gene. Several isoforms of each chain have been described. Different alpha, beta and gamma chain isomers combine to give rise to different heterotrimeric laminin isoforms which are designated by Arabic numerals in the order of their discovery, i.e. alpha1beta1gamma1 heterotrimer is laminin 1. The biological functions of the different chains and trimer molecules are largely unknown, but some of the chains have been shown to differ with respect to their tissue distribution, presumably reflecting diverse functions in vivo. This gene encodes the beta chain isoform laminin, beta 2. The beta 2 chain contains the 7 structural domains typical of beta chains of laminin, including the short alpha region. However, unlike beta 1 chain, beta 2 has a more restricted tissue distribution. It is enriched in the basement membrane of muscles at the neuromuscular junctions, kidney glomerulus and vascular smooth muscle. Transgenic mice in which the beta 2 chain gene was inactivated by homologous recombination, showed defects in the maturation of neuromuscular junctions and impairment of glomerular filtration. Alternative splicing involving a non consensus 5' splice site (gc) in the 5' UTR of this gene has been reported. It was suggested that inefficient splicing of this first intron, which does not change the protein sequence, results in a greater abundance of the unspliced form of the transcript than the spliced form. The full-length nature of the spliced transcript is not known. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 53,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 61,
        "disease_count": 5,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16321",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding;GO:0005198 structural molecule activity;GO:0005201 extracellular matrix structural constituent;GO:0150043 structural constituent of synapse-associated extracellular matrix",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0031012 extracellular matrix;GO:0031594 neuromuscular junction",
        "go_biological_process": "GO:0045785 positive regulation of cell adhesion;GO:0034446 substrate adhesion-dependent cell spreading;GO:0051149 positive regulation of muscle cell differentiation;GO:2001046 positive regulation of integrin-mediated signaling pathway;GO:0110011 regulation of basement membrane organization",
        "synthesized_glycan_count": 0,
        "hit_score": 29.3,
        "record_id": "P55268-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N9N7-1",
        "uniprot_id": [
            {
                "id": "LRC57_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N9N7",
                "type": "external"
            }
        ],
        "mass": 26754.0,
        "length": 239,
        "protein_name": "Leucine-rich repeat-containing protein 57",
        "gene_name": "LRRC57",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 57",
        "refseq_ac": [
            {
                "id": "NP_694992",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694992",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC57",
        "gene_names_refseq": "LRRC57",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 57",
        "protein_names_refseq": "leucine-rich repeat-containing protein 57",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:255252)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "11237011;20068231;25255805;25576301;27600516;28218747;28467828;28834231;28904123;29242379;29393594;29557506;30419947;30573663;30833945;31217245;31844290;31848261;32157095;32350084;33592498;33912179;33968037;34171305;34357683;34932366;35251023",
        "class_list": "",
        "function": "Increased expression of LRRC57 is associated with genetic risk for bipolar disorder. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z2Z6;Q8N1T6",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q8N9N7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q08397-1",
        "uniprot_id": [
            {
                "id": "LOXL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q08397",
                "type": "external"
            }
        ],
        "mass": 63110.0,
        "length": 574,
        "protein_name": "Lysyl oxidase homolog 1",
        "gene_name": "LOXL1",
        "organism": "Human",
        "refseq_name": "lysyl oxidase homolog 1 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_005567",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005567",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LOXL1; LOXL",
        "gene_names_refseq": "LOL; LOXL1; LOXL",
        "protein_names_uniprotkb": "Lysyl oxidase homolog 1; 1.4.3.13; LOL; Lysyl oxidase-like protein 1",
        "protein_names_refseq": "lysyl oxidase homolog 1 preproprotein; lysyl oxidase homolog 1; lysyl oxidase-like protein 1",
        "tax_id": 9606,
        "disease": "primary open angle glaucoma (Disease Ontology:DOID:1070); Kuhnt-Junius degeneration (Disease Ontology:DOID:10873); angle-closure glaucoma (Disease Ontology:DOID:13550); exfoliation syndrome (Disease Ontology:DOID:13641)",
        "pathway": " (hsa:4016);  (R-HSA-1566948);  (R-HSA-2243919)",
        "pathway_count": 3,
        "publication_count": 51,
        "publication_id_list": "10198291;10936461;11237011;11313359;11481325;12211432;1237296;12577300;1348714;1484505;1567360;16906757;17690259;18037624;19343041;19729652;22842973;25275910;25576301;27339457;27846572;29242379;29557506;30459171;31611695;32157095;32350084;32938616;33592498;33968037;34561969;35051231;35328709;35580925;3595596;36010968;36241641;38217541;38267662;38466882;3992061;41816;5246001;5723342;6123066;6129847;641035;7689553;8617364;8636146;9470928",
        "class_list": "",
        "function": "Catalyzes the oxidative deamination of lysine and hydroxylysine residues in collagen and elastin, resulting in the formation of covalent cross-linkages, and the stabilization of collagen and elastin fibers (By similarity). Essential for the elastic fiber homeostasis and for their maintenance at adult age (By similarity)., [UniProtKB, UniProtKB]; Collectively, these results suggest that dysregulation of LOXL1 expression is a contributing factor to exfoliation disease development. Review article, [RefSeq, PubMed]; Comparison and aa sequence alignment of human and rat lysyl oxidase and human LOXL1 Review article, [RefSeq, PubMed]; Crosstalk of lysyl oxidase-like 1 and lysyl oxidase prolongs their half-lives and regulates liver fibrosis through Notch signal. Publication Status: Online-Only, [RefSeq, PubMed]; LOXL1 promotes tumor cell malignancy and restricts CD8 + T cell infiltration in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Mechanism of lysine oxidase-like 1 promoting synovial inflammation mediating rheumatoid arthritis development., [RefSeq, PubMed]; This gene encodes a member of the lysyl oxidase family of proteins. The prototypic member of the family is essential to the biogenesis of connective tissue, encoding an extracellular copper-dependent amine oxidase that catalyzes the first step in the formation of crosslinks in collagen and elastin. The encoded preproprotein is proteolytically processed to generate the mature enzyme. A highly conserved amino acid sequence at the C-terminus end appears to be sufficient for amine oxidase activity, suggesting that each family member may retain this function. The N-terminus is poorly conserved and may impart additional roles in developmental regulation, senescence, tumor suppression, cell growth control, and chemotaxis to each member of the family. Mutations in this gene are associated with exfoliation syndrome. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NUL3;Q96BW7",
        "ec_number_list": [
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "3.4.24.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.19",
                "type": "external"
            },
            {
                "id": "1.4.3.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.13",
                "type": "external"
            },
            {
                "id": "1.4.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.4.3.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005507 copper ion binding;GO:0004720 protein-lysine 6-oxidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0001669 acrosomal vesicle;GO:0005604 basement membrane",
        "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0030199 collagen fibril organization;GO:0035904 aorta development;GO:0018277 protein deamination",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q08397-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P01594-1",
        "uniprot_id": [
            {
                "id": "KV133_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P01594",
                "type": "external"
            }
        ],
        "mass": 12848.0,
        "length": 117,
        "protein_name": "Immunoglobulin kappa variable 1-33",
        "gene_name": "IGKV1-33",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGKV1-33",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin kappa variable 1-33; Ig kappa chain V-I region AU; Ig kappa chain V-I region Ka",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (R-HSA-166663);  (R-HSA-173623);  (R-HSA-198933);  (R-HSA-202733);  (R-HSA-2029481);  (R-HSA-2029482);  (R-HSA-2029485);  (R-HSA-2168880);  (R-HSA-2454202);  (R-HSA-2730905);  (R-HSA-2871796);  (R-HSA-2871809);  (R-HSA-2871837);  (R-HSA-5690714);  (R-HSA-9664323);  (R-HSA-9664422);  (R-HSA-9679191);  (R-HSA-977606);  (R-HSA-983695)",
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        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
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        "go_molecular_function": "GO:0042802 identical protein binding;GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0072562 blood microparticle;GO:0019814 immunoglobulin complex",
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        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P04430-1",
        "uniprot_id": [
            {
                "id": "KV116_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P04430",
                "type": "external"
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        "protein_name": "Immunoglobulin kappa variable 1-16",
        "gene_name": "IGKV1-16",
        "organism": "Human",
        "refseq_name": "",
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        "gene_names_uniprotkb": "IGKV1-16",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin kappa variable 1-16; Ig kappa chain V-I region BAN",
        "protein_names_refseq": "",
        "tax_id": 9606,
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        "pathway": " (R-HSA-166663);  (R-HSA-173623);  (R-HSA-198933);  (R-HSA-202733);  (R-HSA-2029481);  (R-HSA-2029482);  (R-HSA-2029485);  (R-HSA-2168880);  (R-HSA-2454202);  (R-HSA-2730905);  (R-HSA-2871796);  (R-HSA-2871809);  (R-HSA-2871837);  (R-HSA-5690714);  (R-HSA-9664323);  (R-HSA-9664422);  (R-HSA-9679191);  (R-HSA-977606);  (R-HSA-983695)",
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        "class_list": "immunoglobin",
        "function": "V region of the variable domain of immunoglobulin light chains that participates in the antigen recognition (PubMed:24600447). Immunoglobulins, also known as antibodies, are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound immunoglobulins serve as receptors which, upon binding of a specific antigen, trigger the clonal expansion and differentiation of B lymphocytes into immunoglobulins-secreting plasma cells. Secreted immunoglobulins mediate the effector phase of humoral immunity, which results in the elimination of bound antigens (PubMed:20176268, PubMed:22158414). The antigen binding site is formed by the variable domain of one heavy chain, together with that of its associated light chain. Thus, each immunoglobulin has two antigen binding sites with remarkable affinity for a particular antigen. The variable domains are assembled by a process called V-(D)-J rearrangement and can then be subjected to somatic hypermutations which, after exposure to antigen and selection, allow affinity maturation for a particular antigen (PubMed:17576170, PubMed:20176268)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]",
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        "secondary_ac_list": "A0A0A0MT74",
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        "go_molecular_function": "GO:0003823 antigen binding",
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    },
    {
        "uniprot_canonical_ac": "P29536-1",
        "uniprot_id": [
            {
                "id": "LMOD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P29536",
                "type": "external"
            }
        ],
        "mass": 67030.0,
        "length": 600,
        "protein_name": "Leiomodin-1",
        "gene_name": "LMOD1",
        "organism": "Human",
        "refseq_name": "leiomodin-1",
        "refseq_ac": [
            {
                "id": "NP_036266",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036266",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LMOD1",
        "gene_names_refseq": "1D; 64kD; D1; LMOD1; MMIHS3; SM-LMOD; SMLMOD",
        "protein_names_uniprotkb": "Leiomodin-1; 64 kDa autoantigen 1D3; 64 kDa autoantigen 1D; 64 kDa autoantigen D1; Leiomodin, muscle form; SM-Lmod; Smooth muscle leiomodin; Thyroid-associated ophthalmopathy autoantigen",
        "protein_names_refseq": "64 kDa autoantigen 1D3; 64 kDa autoantigen 1D; 64 kDa autoantigen D1; leimodin 1 (smooth muscle); leiomodin 1 (smooth muscle); leiomodin, muscle form; leiomodin-1; smooth muscle leiomodin; thyroid and eye muscle autoantigen D1 (64kD); thyroid-associated ophthalmopathy autoantigen",
        "tax_id": 9606,
        "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); megacystis-microcolon-intestinal hypoperistalsis syndrome 3 (MONDO:MONDO:0030294)",
        "pathway": " (hsa:25802);  (R-HSA-445355)",
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        "class_list": "",
        "function": "LMOD1, an oncogene associated with Lauren classification, regulates the metastasis of gastric cancer cells through the FAK-AKT/mTOR pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Lmod1 is a member of the Tropomodulin family of actin binding proteins, and is most highly expressed in smooth muscle., [RefSeq, PubMed]; Lmod1, formerly the 64kD human autoantigen D1, is expressed in smooth muscle and striated extraocular slow muscle fibers, colocalized with myosin in the contractile apparatus. Protein levels are unaltered by hyperthyroidism., [RefSeq, PubMed]; Loss of LMOD1 results in a reduction of filamentous actin, elongated cytoskeletal dense bodies, and impaired intestinal smooth muscle contractility., [RefSeq, PubMed]; Loss-of-function variants within LMOD1 actin-binding site 2 cause pediatric intestinal pseudo-obstruction by impairing protein stability and actin nucleation., [RefSeq, PubMed]; Required for proper contractility of visceral smooth muscle cells (PubMed:28292896). Mediates nucleation of actin filaments., [UniProtKB, PubMed, PubMed]; Rs34091558 is the top regulatory variant for LMOD1 in vascular tissues. This genetic variation is associated with dysregulated LMOD1 expression/function in smooth muscle cells, contributing to the heritable risk for coronary artery disease. Publication Status: Online-Only, [RefSeq, PubMed]; Spatiotemporal heterogeneity of LMOD1 expression summarizes two modes of cell communication in colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The leiomodin 1 protein has a putative membrane-spanning region and 2 types of tandemly repeated blocks.  The transcript is expressed in all tissues tested, with the highest levels in thyroid, eye muscle, skeletal muscle, and ovary. Increased expression of leiomodin 1 may be linked to Graves' disease and thyroid-associated ophthalmopathy. [provided by RefSeq, Jul 2008]., [RefSeq]",
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        "secondary_ac_list": "B1APV6;C4AMB1;Q68EN2",
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        "go_molecular_function": "GO:0003779 actin binding;GO:0005523 tropomyosin binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0005884 actin filament;GO:0016020 membrane;GO:0005865 striated muscle thin filament",
        "go_biological_process": "GO:0006936 muscle contraction;GO:0007015 actin filament organization;GO:0045010 actin nucleation;GO:0030838 positive regulation of actin filament polymerization;GO:0051694 pointed-end actin filament capping",
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    },
    {
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            {
                "id": "KRR1_HUMAN",
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                "type": "external"
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        ],
        "mass": 43665.0,
        "length": 381,
        "protein_name": "KRR1 small subunit processome component homolog",
        "gene_name": "KRR1",
        "organism": "Human",
        "refseq_name": "KRR1 small subunit processome component homolog",
        "refseq_ac": [
            {
                "id": "NP_008974",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008974",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KRR1; HRB2",
        "gene_names_refseq": "HRB2; KRR1; RIP-1",
        "protein_names_uniprotkb": "KRR1 small subunit processome component homolog; HIV-1 Rev-binding protein 2; KRR-R motif-containing protein 1; Rev-interacting protein 1; Rip-1",
        "protein_names_refseq": "HIV-1 Rev-binding protein 2; HIV-1 rev binding protein 2; KRR-R motif-containing protein 1; KRR1 small subunit processome component homolog; KRR1, small subunit (SSU) processome component, homolog; Rev interacting protein; rev-interacting protein 1",
        "tax_id": 9606,
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        "pathway": " (hsa:11103);  (R-HSA-6790901);  (R-HSA-6791226)",
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        "publication_id_list": "10606270;11081632;11922599;11935223;11978965;12068309;12150911;12417735;12429849;15199136;16037817;16043514;16362076;16381836;16738141;16782898;17081983;17189298;17353269;17412707;17636026;18065403;18438418;19007248;19033376;19106111;19332556;19413330;19463982;19562805;19564402;19651622;19691289;19801658;20038530;20047967;20056613;20068231;20531386;20798176;20805244;20819938;21036871;21063389;21097556;21406692;22072790;22190735;22195017;22916032;23186163;23391857;23439679;23481700;23482395;2388630;24086612;24424021;24550520;24715725;25411247;25525153;25576301;25645385;25653167;25851604;25892735;25969445;26085946;26154972;26196125;26237581;26375851;26992070;27084949;27846572;27862975;27920218;28063628;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30484775;31154438;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32357974;32387766;32502341;32938616;32983136;33123756;33141586;33298915;33691108;33717175;33936100;33968037;34087483;34171305;34211107;34516797;34932366;35051231;35494241;35580925;36241641;36284347;36581221;7724608;9211966;9482744;9512526",
        "class_list": "",
        "function": "Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, PubMed]",
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        "go_molecular_function": "GO:0003723 RNA binding",
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        "go_biological_process": "GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA",
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    {
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                "type": "external"
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        ],
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        "protein_name": "Putative apolipoprotein(a)-like protein 2",
        "gene_name": "LPAL2",
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    {
        "uniprot_canonical_ac": "Q1L5Z9-1",
        "uniprot_id": [
            {
                "id": "LONF2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q1L5Z9",
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        ],
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        "length": 754,
        "protein_name": "LON peptidase N-terminal domain and RING finger protein 2",
        "gene_name": "LONRF2",
        "organism": "Human",
        "refseq_name": "LON peptidase N-terminal domain and RING finger protein 2 isoform 1",
        "refseq_ac": [
            {
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        "gene_names_uniprotkb": "LONRF2; RNF192",
        "gene_names_refseq": "LONRF2; RNF192",
        "protein_names_uniprotkb": "LON peptidase N-terminal domain and RING finger protein 2; Neuroblastoma apoptosis-related protease; RING finger protein 192",
        "protein_names_refseq": "LON peptidase N-terminal domain and RING finger protein 2 isoform 1; LON peptidase N-terminal domain and RING finger protein 2; RING finger protein 192; neuroblastoma apoptosis-related protease",
        "tax_id": 9606,
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        ],
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        "length": 128,
        "protein_name": "KHDC1-like protein",
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        "protein_names_refseq": "KH homology domain containing 1-like; KHDC1-like protein; RP11-257K9.7; putative KHDC1-like protein",
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        "function": "Upregulation of KHDC1L promotes the proliferation and inhibits apoptosis in head and neck squamous cell carcinoma., [RefSeq, PubMed]",
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        ],
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        "protein_name": "Leukemia-associated protein 7",
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        "refseq_name": "leukemia-associated protein 7 isoform 1",
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            {
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        "protein_names_refseq": "leukemia-associated protein 7 isoform 1; leukemia-associated protein 7",
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        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "LRP10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z4F1",
                "type": "external"
            }
        ],
        "mass": 76193.0,
        "length": 713,
        "protein_name": "Low-density lipoprotein receptor-related protein 10",
        "gene_name": "LRP10",
        "organism": "Human",
        "refseq_name": "low-density lipoprotein receptor-related protein 10 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001316155",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316155",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRP10; MSTP087; PRO724; SP220",
        "gene_names_refseq": "LRP-10; LRP10; LRP9; MST087; MSTP087",
        "protein_names_uniprotkb": "Low-density lipoprotein receptor-related protein 10; LRP-10",
        "protein_names_refseq": "low-density lipoprotein receptor-related protein 10 isoform 2 precursor; low-density lipoprotein receptor-related protein 10",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26020);  (R-HSA-975634)",
        "pathway_count": 2,
        "publication_count": 92,
        "publication_id_list": "10.1101/2023.09.13.557529;10052934;10769148;11060341;11123907;11181758;11237011;11274389;1279089;12975309;15358783;1542003;15498874;15583000;16200213;16939223;17525477;17644776;18087047;18295589;18460466;18507396;1856611;18669648;18691976;19014918;19139408;20068231;21106934;21851338;24106281;24190977;25502872;25576301;26154972;26992070;27726376;2793848;28446606;28467828;28871256;28904123;29242379;29314611;29393594;29557506;29741879;30573663;31611695;31844290;32157095;32161166;32350084;32488085;32897882;32938616;32983136;33043033;33592498;33912179;33968037;34078123;34211107;34216936;34246039;34357683;34433824;35051231;35154160;35251023;35318648;36010968;36215666;36434476;37074911;3714052;38315424;38956225;3942763;41018975;4345202;5057882;5675424;6420172;6961410;7683668;8017323;8384721;8728311;9888420;9920938;9925661",
        "class_list": "",
        "function": "Genetic analysis of the LRP10 gene in Chinese patients with Parkinson's disease., [RefSeq, PubMed]; LRP10 and alpha-synuclein transmission in Lewy body diseases. Publication Status: Online-Only, [RefSeq, PubMed]; Lrp10 suppresses IL7R limiting CD8 T cell homeostatic expansion and anti-tumor immunity., [RefSeq, PubMed]; Probable receptor, which is involved in the internalization of lipophilic molecules and/or signal transduction. May be involved in the uptake of lipoprotein APOE in liver (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Role of LRP10 in Parkinson's disease in a Taiwanese cohort., [RefSeq, PubMed]; Screening of LRP10 mutations in Parkinson's disease patients from Italy., [RefSeq, PubMed]; This gene encodes a low density lipoprotein receptor family protein. A similar protein in mouse is thought to play a role in the uptake of apolipoprotein E-containing lipoproteins. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 4,
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        "secondary_ac_list": "A8K4R5;D3DS31;O95882;Q14CK7;Q86T02;Q8NCZ4;Q9HC42;Q9UG33",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005041 low-density lipoprotein particle receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0016020 membrane",
        "go_biological_process": "GO:0006897 endocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "Q7Z4F1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IUC3-1",
        "uniprot_id": [
            {
                "id": "KRA71_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IUC3",
                "type": "external"
            }
        ],
        "mass": 9288.0,
        "length": 87,
        "protein_name": "Keratin-associated protein 7-1",
        "gene_name": "KRTAP7-1",
        "organism": "Human",
        "refseq_name": "keratin-associated protein 7-1",
        "refseq_ac": [
            {
                "id": "NP_853637",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_853637",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KRTAP7-1; KAP7.1; KRTAP7.1",
        "gene_names_refseq": "KAP7.1; KRTAP7-1",
        "protein_names_uniprotkb": "Keratin-associated protein 7-1; High tyrosine-glycine keratin-associated protein 7.1",
        "protein_names_refseq": "high tyrosine-glycine keratin-associated protein 7.1; keratin-associated protein 7-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:337878)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "12359730;33123756",
        "class_list": "",
        "function": "In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins., [UniProtKB]",
        "predicted_glycosites": 0,
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        "missing_score": 10000,
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        "secondary_ac_list": "Q3LI56",
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0005882 intermediate filament",
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        "record_id": "Q8IUC3-1",
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        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IVB5-1",
        "uniprot_id": [
            {
                "id": "LIX1L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IVB5",
                "type": "external"
            }
        ],
        "mass": 36563.0,
        "length": 337,
        "protein_name": "LIX1-like protein",
        "gene_name": "LIX1L",
        "organism": "Human",
        "refseq_name": "LIX1-like protein",
        "refseq_ac": [
            {
                "id": "NP_714924",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_714924",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LIX1L",
        "gene_names_refseq": "LIX1L",
        "protein_names_uniprotkb": "LIX1-like protein",
        "protein_names_refseq": "LIX1-like protein; Lix1 homolog-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:128077)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "15944288;20112406;24714562;26154972;26310847;26811146;26992070;27846572;28228285;28904123;29437277;29493099;29557506;30429286;30484775;31217245;31844290;32157095;32265295;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33592498;33691108;33912179;33968037;33981976;34171305;34509645;34932366;35051231;35561310;35580925;36010968;36284347;37938771",
        "class_list": "",
        "function": "LIX1L is an RNA-binding protein, with implications for therapeutic approaches for targeting LIX1L in LIX1L-expressing cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q6AI36",
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        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0097352 autophagosome maturation",
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        "record_id": "Q8IVB5-1",
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        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "LRC34_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IZ02",
                "type": "external"
            }
        ],
        "mass": 51277.0,
        "length": 464,
        "protein_name": "Leucine-rich repeat-containing protein 34",
        "gene_name": "LRRC34",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 34 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001166250",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001166250",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC34",
        "gene_names_refseq": "LRRC34",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 34",
        "protein_names_refseq": "leucine-rich repeat-containing protein 34 isoform 2; leucine-rich repeat-containing protein 34",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:151827)",
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        "publication_count": 4,
        "publication_id_list": "24991885;26992070;32051256;32387766",
        "class_list": "",
        "function": "Highly expressed in stem cells where it may be involved in regulation of pluripotency. In embryonic stem cells (ESCs), important for normal expression of the pluripotency regulators POU5F1/OCT4 and KLF4. Also important for expression of the ectodermal marker gene NES and the endodermal marker gene GATA4. Promotes stem cell proliferation in vitro., [UniProtKB, UniProtKB]; LRRC34 is a novel nucleolar protein that is predominantly expressed in pluripotent stem cells., [RefSeq, PubMed]; Variants in LRRC34 reveal distinct mechanisms for predisposition to papillary thyroid carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "B4DEJ7;E9PBH2;G5E9T7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8IZ02-2",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N109-1",
        "uniprot_id": [
            {
                "id": "KI2LA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N109",
                "type": "external"
            }
        ],
        "mass": 40678.0,
        "length": 375,
        "protein_name": "Killer cell immunoglobulin-like receptor 2DL5A",
        "gene_name": "KIR2DL5A",
        "organism": "Human",
        "refseq_name": "killer cell immunoglobulin-like receptor 2DL5A precursor",
        "refseq_ac": [
            {
                "id": "NP_065396",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065396",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KIR2DL5A; CD158F1; CD158F; KIR2DL5",
        "gene_names_refseq": "CD158F; KIR2DL5.1; KIR2DL5.3; KIR2DL5A; KIR2DL5",
        "protein_names_uniprotkb": "Killer cell immunoglobulin-like receptor 2DL5A",
        "protein_names_refseq": "killer cell immunoglobulin-like receptor 2DL5A precursor; killer cell immunoglobulin-like receptor 2DL5A; killer cell immunoglobulin-like receptor KIR2DL5A; killer cell immunoglobulin-like receptor, two domains, long cytoplasmic tail, 5A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57292)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "12121272;12185535;15140215;28548933;28993188;36720995",
        "class_list": "",
        "function": "Association of KIR2DL5, KIR2DS5, and KIR2DS1 allelic variation and atopic dermatitis. Publication Status: Online-Only, [RefSeq, PubMed]; Human KIR2DL5 has at least 4 gene variants, whose exons differ by 2 to 8 nucleotides. These structurally similar variants are encoded by alleles of 2 different loci, KIR2DL5A and KIR2DL5B, which map to different regions of the KIR-gene cluster., [RefSeq, PubMed]; KIR 2DL5 was associated with decreased CMV infection and better platelets engraftment after hematopoietic stem cell transplantation from matched sibling, [RefSeq, PubMed]; Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several 'framework' genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]., [RefSeq]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Receptor on natural killer (NK) cells for HLA-C alleles. Inhibits the activity of NK cells thus preventing cell lysis., [UniProtKB]; The frequencies of KIR2DS1 and KIR2DL5 were significantly increased in psoriasis vulgaris cases compared with controls GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; These findings establish KIR2DL5 as a new Schwann cell growth regulator relevant to sp-DNF pathogenesis, which links sporadic and NF1-associated DNFs through RAS pathway hyperactivation., [RefSeq, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0140375 immune receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8N109-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N456-1",
        "uniprot_id": [
            {
                "id": "LRC18_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N456",
                "type": "external"
            }
        ],
        "mass": 29737.0,
        "length": 261,
        "protein_name": "Leucine-rich repeat-containing protein 18",
        "gene_name": "LRRC18",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 18",
        "refseq_ac": [
            {
                "id": "NP_001006940",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006940",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC18; PRO34010",
        "gene_names_refseq": "LRRC18; UNQ9338; UNQ933; VKGE9338",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 18",
        "protein_names_refseq": "leucine-rich repeat-containing protein 18",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:474354)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "12975309;28832583;33686958",
        "class_list": "",
        "function": "Identification of key genes in coronary artery disease: an integrative approach based on weighted gene co-expression network analysis and their correlation with immune infiltration., [RefSeq, PubMed]; May be involved in the regulation of spermatogenesis and sperm maturation., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6UY02",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0035556 intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q8N456-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N7Y1-1",
        "uniprot_id": [
            {
                "id": "KIAS3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N7Y1",
                "type": "external"
            }
        ],
        "mass": 25772.0,
        "length": 241,
        "protein_name": "Putative uncharacterized protein KIRREL3-AS3",
        "gene_name": "KIRREL3-AS3",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "KIRREL3-AS3; NCRNA00288; PRR10",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein KIRREL3-AS3; KIRREL3 antisense RNA 1; KIRREL3 antisense gene protein 1; Proline-rich protein 10",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
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        "biomarker_type": "",
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        "secondary_ac_list": "Q14CX1",
        "ec_number_list": [],
        "go_molecular_function": "",
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        "synthesized_glycan_count": 0,
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        "record_id": "Q8N7Y1-1",
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        "filter_code": "0000000.0000000.100000.000000000001000000.0000000001000.001.00000",
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    },
    {
        "uniprot_canonical_ac": "Q8NBH2-4",
        "uniprot_id": [
            {
                "id": "KY_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NBH2",
                "type": "external"
            }
        ],
        "mass": 75153.0,
        "length": 661,
        "protein_name": "Kyphoscoliosis peptidase",
        "gene_name": "KY",
        "organism": "Human",
        "refseq_name": "kyphoscoliosis peptidase isoform 1",
        "refseq_ac": [
            {
                "id": "NP_848649",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848649",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KY",
        "gene_names_refseq": "KY; MFM7",
        "protein_names_uniprotkb": "Kyphoscoliosis peptidase; 3.4.-.-",
        "protein_names_refseq": "kyphoscoliosis peptidase isoform 1",
        "tax_id": 9606,
        "disease": "myofibrillar myopathy 7 (Disease Ontology:DOID:0080098)",
        "pathway": " (hsa:339855)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "15385448;27484770;27485408;28005267;28488683;30379171;32818658",
        "class_list": "",
        "function": "A novel homozygous KY variant causing a complex neurological disorder., [RefSeq, PubMed]; Homozygous KY mutation was identified as a cause of progressive hereditary spastic paraplegia.  High KY transcript levels were demonstrated in muscular organs and lower expression in the CNS., [RefSeq, PubMed]; Homozygous c.1071delG, p.(Thr358Leufs*3) variant of KY causes neuromuscular disorder by introducing a premature stop codon., [RefSeq, PubMed]; KY expression is significantly downregulated in human masticatory mucosa during wound healing, [RefSeq, PubMed]; Probable cytoskeleton-associated protease required for normal muscle growth. Involved in function, maturation and stabilization of the neuromuscular junction. May act by cleaving muscle-specific proteins such as FLNC (By similarity)., [UniProtKB]; The protein encoded by this gene belongs to the transglutaminase-like superfamily. The protein is involved in the function, maturation and stabilization of the neuromuscular junction and may be required for normal muscle growth. Mutations in this gene are associated with myopathy, myofibrillar, 7. [provided by RefSeq, Apr 2017]., [RefSeq]; This study shown Kyphoscoliosis peptidase (KY) mutation causes a novel congenital myopathy with core targetoid defects in two bother., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "B7Z1S4;Q6ZT15",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008233 peptidase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0030018 Z disc",
        "go_biological_process": "GO:0006508 proteolysis;GO:0007528 neuromuscular junction development;GO:0007517 muscle organ development",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q8NBH2-4",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TF66-1",
        "uniprot_id": [
            {
                "id": "LRC15_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TF66",
                "type": "external"
            }
        ],
        "mass": 64366.0,
        "length": 581,
        "protein_name": "Leucine-rich repeat-containing protein 15",
        "gene_name": "LRRC15",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 15 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001128529",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128529",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC15; LIB",
        "gene_names_refseq": "LIB; LRRC15",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 15; Leucine-rich repeat protein induced by beta-amyloid homolog; hLib",
        "protein_names_refseq": "hLib; leucine-rich repeat protein induced by beta amyloid; leucine-rich repeat protein induced by beta-amyloid homolog; leucine-rich repeat-containing protein 15 isoform a precursor; leucine-rich repeat-containing protein 15",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:131578)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "11785964;12923058;16098915;18385238;27600516;29557506;29741879;30484775;31844290;32161166;32938616;33592498;34211107;34702854;35051231;36010968;36228039;36735681;36757924;38051601;38566328;38763774",
        "class_list": "",
        "function": "(Microbial infection) Modulates the ability of SARS-CoV-2 to infect host cells through interaction with the spike protein (PubMed:36228039, PubMed:36735681, PubMed:36757924). Does not act as a SARS-CoV-2 entry receptor but sequesters virions and antagonizes in trans SARS-CoV-2 infection of ACE2(+) cells when expressed on nearby cells (PubMed:36228039, PubMed:36757924)., [UniProtKB, PubMed, PubMed, PubMed]; Effect of LRRC15 on autophagy in A549 cells., [RefSeq, PubMed]; Fibroblast-expressed LRRC15 is a receptor for SARS-CoV-2 spike and controls antiviral and antifibrotic transcriptional programs. Publication Status: Online-Only, [RefSeq, PubMed]; Integrated bioinformatics analysis identified leucine rich repeat containing 15 and secreted phosphoprotein 1 as hub genes for calcific aortic valve disease and osteoarthritis., [RefSeq, PubMed]; LRRC15 is induced by EWS-WT1(+KTS) in the tumor DSRCT and may play a role in cellular invasion., [RefSeq, PubMed]; Leucine-Rich Repeat Containing 15-Mediated Cell Adhesion Is Essential for Integrin Signaling in TGF-beta1-Induced PDL Fibroblastic Differentiation., [RefSeq, PubMed]; Lib may contribute to regulation of cell-matrix adhesion interactions with respect to astrocyte recruitment around senile plaques in Alzheimer's disease brain, [RefSeq, PubMed]; Tumor antigen LRRC15 impedes adenoviral infection: implications for virus-based cancer therapy are presented., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
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        "missing_score": 8657,
        "biomarker_type": "",
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        "secondary_ac_list": "Q495Q6;Q7RTN7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005518 collagen binding;GO:0043236 laminin binding;GO:0001968 fibronectin binding;GO:0038023 signaling receptor activity;GO:0140311 protein sequestering activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0030335 positive regulation of cell migration;GO:0051965 positive regulation of synapse assembly;GO:0046813 receptor-mediated virion attachment to host cell;GO:1903077 negative regulation of protein localization to plasma membrane;GO:0046597 host-mediated suppression of symbiont invasion",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q8TF66-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96JA1-1",
        "uniprot_id": [
            {
                "id": "LRIG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96JA1",
                "type": "external"
            }
        ],
        "mass": 119113.0,
        "length": 1093,
        "protein_name": "Leucine-rich repeats and immunoglobulin-like domains protein 1",
        "gene_name": "LRIG1",
        "organism": "Human",
        "refseq_name": "leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_056356",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056356",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRIG1; LIG1",
        "gene_names_refseq": "LIG-1; LIG1; LRIG1",
        "protein_names_uniprotkb": "Leucine-rich repeats and immunoglobulin-like domains protein 1; LIG-1",
        "protein_names_refseq": "leucine-rich repeat protein LRIG1; leucine-rich repeats and immunoglobulin-like domains protein 1 isoform 1 precursor; leucine-rich repeats and immunoglobulin-like domains protein 1; ortholog of mouse integral membrane glycoprotein LIG-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26018);  (R-HSA-177929);  (R-HSA-6807004);  (R-HSA-9725554)",
        "pathway_count": 4,
        "publication_count": 80,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;11414704;11741535;11894096;12067728;12234026;12244174;12475979;12551915;12624109;12684867;12686592;15123609;15140226;15234001;15282549;15556625;15675955;15780751;15828871;16113677;16227611;16297201;1688559;17178829;17330888;18819921;19109251;19924134;2022652;22735594;23090970;23208509;23283814;23584533;23629652;23912460;24190977;24794495;24828152;2543678;25576301;25765764;25813380;25892735;26340985;26992070;27862975;27893789;28228285;29242379;29314611;29393594;29557506;29769354;30905808;31075398;31399284;31844290;32350084;32938616;33592498;33936100;34087483;34171305;34357683;34576152;34932366;35051231;35154160;35440669;36010968;38253038;38376291;38454507;38758807;8639530;8845374",
        "class_list": "",
        "function": "Aberrant promoter methylation contributes to LRIG1 silencing in basal/triple-negative breast cancer., [RefSeq, PubMed]; Acts as a feedback negative regulator of signaling by receptor tyrosine kinases, through a mechanism that involves enhancement of receptor ubiquitination and accelerated intracellular degradation., [UniProtKB, PubMed]; Aryl Hydrocarbon Receptor Defect Attenuates Mitogen-Activated Signaling through Leucine-Rich Repeats and Immunoglobulin-like Domains 1 (LRIG1)-Dependent EGFR Degradation. Publication Status: Online-Only, [RefSeq, PubMed]; Down-regulation of LIG-1 is associated with cancer, [RefSeq, PubMed]; Dysregulation and antimetastatic function of circLRIG1 modulated by miR-214-3p/LRIG1 axis in bladder carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; LRIG1 engages ligand VISTA and impairs tumor-specific CD8[+] T cell responses., [RefSeq, PubMed]; Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1) is downregulated in Invasive ductal carcinoma and potential prognostic marker of breast cancer., [RefSeq, PubMed]; Results demonstrate that LRIG1 is an integral cell-surface membrane protein that is expressed by specific cells in various human tissues and that its 143-kDa form might be cleaved into 111-kDa and 32-kDa fragments., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
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        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 7,
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        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 3,
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        "total_n_glycosites": 7,
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        "secondary_ac_list": "Q6IQ51;Q96CF9;Q9BYB8;Q9UFI4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007605 sensory perception of sound",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q96JA1-1",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96QS6-1",
        "uniprot_id": [
            {
                "id": "PSKH2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96QS6",
                "type": "external"
            }
        ],
        "mass": 43027.0,
        "length": 385,
        "protein_name": "Serine/threonine-protein kinase H2",
        "gene_name": "PSKH2",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase H2",
        "refseq_ac": [
            {
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_149117",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PSKH2",
        "gene_names_refseq": "PSKH2",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase H2; 2.7.11.1; PSK-H2; Protein serine kinase H2",
        "protein_names_refseq": "serine/threonine kinase PSKH2; serine/threonine-protein kinase H2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:85481)",
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        "publication_id_list": "12471243;17344846;29242379;33968037;35051231",
        "class_list": "",
        "function": "First description of PSKH2, predicted as a catalytically-active protein kinase homolog of PSKH1. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "protein_name": "Protein lin-28 homolog A",
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        "publication_id_list": "12787505;12798299;14688391;15003116;15108323;15277698;15342930;15493035;15513931;15582778;15614775;15625129;15695770;15722555;15743839;15860457;15983365;15988017;16153702;16227573;16978057;17068183;17204602;17267691;17506876;17567999;17572666;17617744;17628018;18029452;18035408;18212089;18824471;18951094;19151334;19483683;19489980;19522013;19604364;19664995;19688839;19703396;19755485;19829295;19966271;20027182;20505756;20505821;20837710;20953172;21247876;21406692;21630377;21924763;22118463;22157959;22210884;22215994;22223895;22327294;22898984;22988117;23178592;23827706;23827708;29351928;29540527;34171305;37217939;38636252;38729326;38745302;39148295;9000051",
        "class_list": "",
        "function": "GNAI3 mediated by Lin28A regulates lipopolysaccharide-induced inflammation and osteogenic differentiation in periodontal stem cells by mediating the NF-kappaB/NLRP3 inflammasome pathway., [RefSeq, PubMed]; Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury., [RefSeq, PubMed]; MiR-92a-3p Knockdown Attenuates Transforming Growth Factor-beta1-induced Tubulointerstitial Fibrosis by Targeting LIN28A-mediated EMT Pathway., [RefSeq, PubMed]; MicroRNA regulation is a conserved feature of the Lin-28 gene in diverse animals. Erratum:[Dev Biol. 2003 Oct 15;262(2):361], [RefSeq, PubMed]; Proto-oncogene c-Myb potentiates cisplatin resistance of ovarian cancer cells by downregulating lncRNA NKILA and modulating cancer stemness and LIN28A-let7 axis. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein that inhibits processing of pre-let-7 miRNAs and regulates translation of mRNAs that control developmental timing, pluripotency and metabolism (PubMed:21247876). Seems to recognize a common structural G-quartet (G4) feature in its miRNA and mRNA targets (Probable). 'Translational enhancer' that drives specific mRNAs to polysomes and increases the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in mRNA stabilization. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Suppressor of microRNA (miRNA) biogenesis, including that of let-7, miR107, miR-143 and miR-200c. Specifically binds the miRNA precursors (pre-miRNAs), recognizing an 5'-GGAG-3' motif found in pre-miRNA terminal loop, and recruits TUT4 and TUT7 uridylyltransferases (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). This results in the terminal uridylation of target pre-miRNAs (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Uridylated pre-miRNAs fail to be processed by Dicer and undergo degradation. The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state by preventing let-7-mediated differentiation of embryonic stem cells (PubMed:18951094, PubMed:19703396, PubMed:22118463, PubMed:22898984). Localized to the periendoplasmic reticulum area, binds to a large number of spliced mRNAs and inhibits the translation of mRNAs destined for the ER, reducing the synthesis of transmembrane proteins, ER or Golgi lumen proteins, and secretory proteins. Binds to and enhances the translation of mRNAs for several metabolic enzymes, such as PFKP, PDHA1 or SDHA, increasing glycolysis and oxidative phosphorylation. Which, with the let-7 repression may enhance tissue repair in adult tissue (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Study shows that LIN28 and LIN28B are overexpressed in primary human tumors and human cancer cell lines (overall frequency approximately 15%), and that overexpression is linked to repression of let-7 family miRNAs and derepression of let-7 targets., [RefSeq, PubMed]; This gene encodes a LIN-28 family RNA-binding protein that acts as a posttranscriptional regulator of genes involved in developmental timing and self-renewal in embryonic stem cells. The encoded protein functions through direct interaction with target mRNAs and by disrupting the maturation of certain miRNAs involved in embryonic development. This protein prevents the terminal processing of the LET7 family of microRNAs which are major regulators of cellular growth and differentiation. Aberrant expression of this gene is associated with cancer progression in multiple tissues. [provided by RefSeq, Sep 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990825 sequence-specific mRNA binding;GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0008270 zinc ion binding;GO:0035198 miRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol",
        "go_biological_process": "GO:2000767 positive regulation of cytoplasmic translation;GO:0048863 stem cell differentiation;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0071333 cellular response to glucose stimulus;GO:0032008 positive regulation of TOR signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q9H9Z2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NVR5-1",
        "uniprot_id": [
            {
                "id": "KTU_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NVR5",
                "type": "external"
            }
        ],
        "mass": 91114.0,
        "length": 837,
        "protein_name": "Protein kintoun",
        "gene_name": "DNAAF2",
        "organism": "Human",
        "refseq_name": "protein kintoun isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001077377",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077377",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "DNAAF2; C14orf104; KTU",
        "gene_names_refseq": "C14orf104; CILD10; DNAAF2; KTU; PF13",
        "protein_names_uniprotkb": "Protein kintoun; Dynein assembly factor 2, axonemal",
        "protein_names_refseq": "dynein assembly factor 2, axonemal; kintoun; protein kintoun isoform 2; protein kintoun",
        "tax_id": 9606,
        "disease": "primary ciliary dyskinesia 10 (Disease Ontology:DOID:0110612)",
        "pathway": " (hsa:55172)",
        "pathway_count": 1,
        "publication_count": 58,
        "publication_id_list": "18669648;18691976;19052621;19651622;20068231;22544926;23186163;23301498;23481700;23872636;24714562;24715725;25186273;25576301;25645385;26154972;26728094;26811146;26992070;27846572;28041644;28228285;28832583;28904123;29242379;29508533;29557506;29632711;29643231;29727693;29786170;29789417;30315122;30379171;30429286;31092671;31530632;31844290;31848261;31937595;32157095;32350084;32387766;32488085;32502341;32638265;32938616;33141586;33298915;33936100;33968037;34171305;34211107;34509645;34932366;35051231;37938771;38053031",
        "class_list": "",
        "function": "Clinical and genetic analysis of two patients with primary ciliary dyskinesia caused by a novel variant of DNAAF2. Publication Status: Online-Only, [RefSeq, PubMed]; Ktu/PF13 is one of the long-sought proteins involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment., [RefSeq, PubMed]; Novel compound heterozygous DNAAF2 mutations cause primary ciliary dyskinesia in a Han Chinese family., [RefSeq, PubMed]; Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment., [UniProtKB, HAMAP]; This gene encodes a highly conserved protein involved in the preassembly of dynein arm complexes which power cilia. These complexes are found in some cilia and are assembled in the cytoplasm prior to transport for cilia formation. Mutations in this gene have been associated with primary ciliary dyskinesia. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B9WS54;C0JAP7;Q86TR1;Q86TY8;Q969Z5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0120293 dynein axonemal particle",
        "go_biological_process": "GO:0003351 epithelial cilium movement involved in extracellular fluid movement;GO:0050821 protein stabilization;GO:0060285 cilium-dependent cell motility;GO:0070286 axonemal dynein complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q9NVR5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NDP7-1",
        "uniprot_id": [
            {
                "id": "MADL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NDP7",
                "type": "external"
            }
        ],
        "mass": 32967.0,
        "length": 307,
        "protein_name": "Myeloid-associated differentiation marker-like protein 2",
        "gene_name": "MYADML2",
        "organism": "Human",
        "refseq_name": "myeloid-associated differentiation marker-like protein 2",
        "refseq_ac": [
            {
                "id": "NP_001138585",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138585",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYADML2",
        "gene_names_refseq": "MYADML2",
        "protein_names_uniprotkb": "Myeloid-associated differentiation marker-like protein 2",
        "protein_names_refseq": "myeloid-associated differentiation marker-like protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:255275)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "25892735;32778762",
        "class_list": "",
        "function": "Homozygous deletion of MYADML2 in cranial asymmetry, reduced bone maturation, multiple dislocations, lumbar lordosis, and prominent clavicles., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "A6NDP7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NNE9-1",
        "uniprot_id": [
            {
                "id": "MARHB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NNE9",
                "type": "external"
            }
        ],
        "mass": 43878.0,
        "length": 402,
        "protein_name": "E3 ubiquitin-protein ligase MARCHF11",
        "gene_name": "MARCHF11",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase MARCHF11",
        "refseq_ac": [
            {
                "id": "NP_001096032",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096032",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MARCHF11; MARCH11",
        "gene_names_refseq": "MARCH-XI; MARCH11; MARCHF11; RNF226",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF11; 2.3.2.27; MARCH-XI; Membrane-associated RING finger protein 11; Membrane-associated RING-CH protein XI; RING-type E3 ubiquitin transferase MARCHF11",
        "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH11; E3 ubiquitin-protein ligase MARCHF11; RING-type E3 ubiquitin transferase MARCH11; RING-type E3 ubiquitin transferase MARCHF11; membrane associated ring finger 11; membrane-associated RING finger protein 11; membrane-associated RING-CH protein XI; membrane-associated ring finger (C3HC4) 11; ring finger protein 226",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:441061)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;29557506;30379171;30418433;32357974;32387766;33968037;35051231;36010968;36215666;38858548",
        "class_list": "",
        "function": "Anaplastic Lymphoma Kinase signaling stabilizes SLC3A2 expression via MARCH11 to promote neuroblastoma cell growth., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that mediates polyubiquitination of CD4. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates. May play a role in ubuquitin-dependent protein sorting in developmenting spermatids., [UniProtKB, UniProtKB]; MARCH11 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). These enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their intracellular transport. March11 appears to have a role in ubiquitin-mediated protein sorting in the trans-Golgi network (TGN)-multivesicular body (MVB) transport pathway (Morokuma et al., 2007 [PubMed 17604280]).[supplied by OMIM, Apr 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7E2S6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0030659 cytoplasmic vesicle membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "A6NNE9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14392-1",
        "uniprot_id": [
            {
                "id": "LRC32_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14392",
                "type": "external"
            }
        ],
        "mass": 71979.0,
        "length": 662,
        "protein_name": "Transforming growth factor beta activator LRRC32",
        "gene_name": "LRRC32",
        "organism": "Human",
        "refseq_name": "transforming growth factor beta activator LRRC32 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001122394",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001122394",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC32; D11S833E",
        "gene_names_refseq": "CPPRDD; D11S833E; GARP; LRRC32",
        "protein_names_uniprotkb": "Transforming growth factor beta activator LRRC32; GARP; Garpin; Glycoprotein A repetitions predominant; Leucine-rich repeat-containing protein 32",
        "protein_names_refseq": "garpin; glycoprotein A repetitions predominant; leucine-rich repeat-containing protein 32; transforming growth factor beta activator LRRC32 isoform a precursor; transforming growth factor beta activator LRRC32",
        "tax_id": 9606,
        "disease": "cleft palate, proliferative retinopathy, and developmental delay (MONDO:MONDO:0033641)",
        "pathway": " (hsa:2615)",
        "pathway_count": 1,
        "publication_count": 37,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;18628982;19159218;19651619;19750484;21615933;21654843;22278742;23481700;24190977;24715725;26126825;27846572;29557506;29632046;29632711;29786170;30429286;30573663;30976112;31844290;32387766;32938616;32983136;33141586;34357683;35051231;35580925;36284347;36460874;36683084;37074911;37348791;38253038;38698265;8180135",
        "class_list": "",
        "function": "Analysis of LAP[+] and GARP[+] Treg subsets in peripheral blood of patients with neuromyelitis optica spectrum disorders., [RefSeq, PubMed]; GARP on hepatic stellate cells is essential for the development of liver fibrosis., [RefSeq, PubMed]; Key regulator of transforming growth factor beta (TGFB1, TGFB2 and TGFB3) that controls TGF-beta activation by maintaining it in a latent state during storage in extracellular space (PubMed:19651619, PubMed:19750484, PubMed:22278742). Associates specifically via disulfide bonds with the Latency-associated peptide (LAP), which is the regulatory chain of TGF-beta, and regulates integrin-dependent activation of TGF-beta (PubMed:22278742). Able to outcompete LTBP1 for binding to LAP regulatory chain of TGF-beta (PubMed:22278742). Controls activation of TGF-beta-1 (TGFB1) on the surface of activated regulatory T-cells (Tregs) (PubMed:19651619, PubMed:19750484). Required for epithelial fusion during palate development by regulating activation of TGF-beta-3 (TGFB3) (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; New insight into GARP striking role in cancer progression: application for cancer therapy. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Suppression of lysosome metabolism-meditated GARP/TGF-beta1 complexes specifically depletes regulatory T cells to inhibit breast cancer metastasis., [RefSeq, PubMed]; This gene encodes a type I membrane protein which contains 20 leucine-rich repeats. Alterations in the chromosomal region 11q13-11q14 are involved in several pathologies. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
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        "biomarker_type": "",
        "glycan_count": 9,
        "disease_count": 1,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86V06",
        "ec_number_list": [],
        "go_molecular_function": "GO:0050431 transforming growth factor beta binding;GO:0038023 signaling receptor activity;GO:0141069 receptor ligand inhibitor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0007179 transforming growth factor beta receptor signaling pathway;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0062009 secondary palate development;GO:0035592 establishment of protein localization to extracellular region",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q14392-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HCJ2-1",
        "uniprot_id": [
            {
                "id": "LRC4C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HCJ2",
                "type": "external"
            }
        ],
        "mass": 71950.0,
        "length": 640,
        "protein_name": "Leucine-rich repeat-containing protein 4C",
        "gene_name": "LRRC4C",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 4C precursor",
        "refseq_ac": [
            {
                "id": "NP_001245348",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245348",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC4C; KIAA1580; NGL1; PRO331",
        "gene_names_refseq": "LRRC4C; NGL-1; NGL1",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 4C; NGL-1; Netrin-G1 ligand",
        "protein_names_refseq": "leucine-rich repeat-containing protein 4C precursor; leucine-rich repeat-containing protein 4C; netrin-G ligand-1; netrin-G1 ligand",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57689)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12975309;14595443;20029409;21946559;22922712;27759917;29557506;32387766;35051231;35580925;39894887",
        "class_list": "",
        "function": "May promote neurite outgrowth of developing thalamic neurons., [UniProtKB, PubMed]; NGL-1 is most abundant in the striatum and the cerebral cortex--the intermediate and final targets, of thalamocortical axons; surface-bound NGL-1 stimulates, but soluble NGL-1 disrupts, the growth of embryonic thalamic axons. GeneRIF: netrin-G1 functions as an important component of the NGL-1 receptor to promote TCA outgrowth and that membrane-bound netrins can participate in receiving axonal signaling pathways., [RefSeq, PubMed]; NGL1 is a specific binding partner for netrin G1 (NTNG1; MIM 608818), which is a member of the netrin family of axon guidance molecules (Lin et al., 2003 [PubMed 14595443]).[supplied by OMIM, Mar 2008]., [RefSeq]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; These data suggest that the proband's autism may be due to the inheritance of disruptions in both DPP6 and LRRC4C, and may highlight the importance of the netrin G family and potassium channel interacting molecules in neurodevelopmental disorders., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
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        "reported_mutagensis": 0,
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        "reported_snv": 43,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K0T1;Q7L0N3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0050839 cell adhesion molecule binding;GO:0098632 cell-cell adhesion mediator activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0098839 postsynaptic density membrane",
        "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0050804 modulation of chemical synaptic transmission;GO:0099560 synaptic membrane adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q9HCJ2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95867-1",
        "uniprot_id": [
            {
                "id": "LY66C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95867",
                "type": "external"
            }
        ],
        "mass": 13821.0,
        "length": 125,
        "protein_name": "Lymphocyte antigen 6 complex locus protein G6c",
        "gene_name": "LY6G6C",
        "organism": "Human",
        "refseq_name": "lymphocyte antigen 6 complex locus protein G6c precursor",
        "refseq_ac": [
            {
                "id": "NP_079537",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079537",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LY6G6C; C6orf24; G6C; NG24; PRO4430",
        "gene_names_refseq": "C6orf24; G6c; LY6G6C; NG24",
        "protein_names_uniprotkb": "Lymphocyte antigen 6 complex locus protein G6c",
        "protein_names_refseq": "lymphocyte antigen 6 complex locus protein G6c precursor; lymphocyte antigen 6 complex locus protein G6c; lymphocyte antigen 6 complex, locus G6C; lymphocyte antigen-6 G6C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80740);  (R-HSA-163125)",
        "pathway_count": 2,
        "publication_count": 14,
        "publication_id_list": "10384126;11072085;11237011;12079290;12975309;14656967;17008713;19851445;19913121;20628086;2443973;24715725;31844290;3422494",
        "class_list": "",
        "function": "LY6G6C belongs to a cluster of leukocyte antigen-6 (LY6) genes located in the major histocompatibility complex (MHC) class III region on chromosome 6. Members of the LY6 superfamily typically contain 70 to 80 amino acids, including 8 to 10 cysteines. Most LY6 proteins are attached to the cell surface by a glycosylphosphatidylinositol (GPI) anchor that is directly involved in signal transduction (Mallya et al., 2002 [PubMed 12079290]).[supplied by OMIM, Mar 2008]., [RefSeq]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
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        "missing_score": 10000,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5SRS8;Q8IY94",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0032991 protein-containing complex;GO:0098552 side of membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "O95867-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NT99-1",
        "uniprot_id": [
            {
                "id": "LRC4B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NT99",
                "type": "external"
            }
        ],
        "mass": 76434.0,
        "length": 713,
        "protein_name": "Leucine-rich repeat-containing protein 4B",
        "gene_name": "LRRC4B",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 4B precursor",
        "refseq_ac": [
            {
                "id": "NP_001073926",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073926",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC4B; LRIG4",
        "gene_names_refseq": "HSM; LRIG4; LRRC4B; NGL-3",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 4B; NGL-3; Netrin-G3 ligand",
        "protein_names_refseq": "leucine-rich repeat-containing protein 4B precursor; leucine-rich repeat-containing protein 4B; leucine-rich repeats and immunoglobulin-like domains 4; netrin-G ligand-3; netrin-G3 ligand",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:94030);  (R-HSA-388844)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15750591;19252495;19413330;20139422;21262467;21940441;22286174;22357843;23345436;25385546;25908590;28228285;29557506;30459171;31154438;32350084;32983136;33936100;34087483;34357683;35051231;35251023;36010968;38253038;7796809;9624153",
        "class_list": "",
        "function": "Synaptic adhesion protein. Regulates the formation of excitatory synapses. The trans-synaptic adhesion between LRRC4B and PTPRF regulates the formation of excitatory synapses in a bidirectional manner (By similarity)., [UniProtKB]",
        "predicted_glycosites": 8,
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        "biomarker_type": "",
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        "secondary_ac_list": "Q3ZCQ4;Q58F20",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0098632 cell-cell adhesion mediator activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0042734 presynaptic membrane;GO:0044300 cerebellar mossy fiber;GO:0098839 postsynaptic density membrane",
        "go_biological_process": "GO:0051965 positive regulation of synapse assembly;GO:0099560 synaptic membrane adhesion;GO:1905606 regulation of presynapse assembly;GO:0099151 regulation of postsynaptic density assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q9NT99-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60299-1",
        "uniprot_id": [
            {
                "id": "LZTS3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60299",
                "type": "external"
            }
        ],
        "mass": 71791.0,
        "length": 673,
        "protein_name": "Leucine zipper putative tumor suppressor 3",
        "gene_name": "LZTS3",
        "organism": "Human",
        "refseq_name": "leucine zipper putative tumor suppressor 3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001269462",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269462",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LZTS3; KIAA0552; PROSAPIP1",
        "gene_names_refseq": "LZTS3; PROSAPIP1",
        "protein_names_uniprotkb": "Leucine zipper putative tumor suppressor 3; ProSAP-interacting protein 1; ProSAPiP1",
        "protein_names_refseq": "ProSAP/Shank-interacting protein 1; leucine zipper putative tumor suppressor 3 isoform 2; leucine zipper, putative tumor suppressor family member 3; proline rich synapse associated protein interacting protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9762)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "21840719;30379171;31154438;31844290;32157095;33315502;33592498;33968037;34405274;35051231;36010968;37806182",
        "class_list": "",
        "function": "LZTS3/TAGLN Suppresses Cancer Progression in Human Colorectal Adenocarcinoma Through Regulating Cell Proliferation, Migration, and Actin Cytoskeleton., [RefSeq, PubMed]; Long non-coding RNA (lncRNA) PGM5P4-AS1 inhibits lung cancer progression by up-regulating leucine zipper tumor suppressor (LZTS3) through sponging microRNA miR-1275., [RefSeq, PubMed]; May be involved in promoting the maturation of dendritic spines, probably via regulating SIPA1L1 levels at the postsynaptic density of synapses., [UniProtKB, UniProtKB]; We thus propose a model where ProSAP/Shank proteins are in the center of a postsynaptic signaling pathway that is disrupted in several neuropsychiatric disorders. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
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        "secondary_ac_list": "A2A2Q7;D3DVX6;Q8IXX8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0043197 dendritic spine;GO:0045202 synapse",
        "go_biological_process": "GO:0061001 regulation of dendritic spine morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "O60299-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60942-1",
        "uniprot_id": [
            {
                "id": "MCE1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60942",
                "type": "external"
            }
        ],
        "mass": 68557.0,
        "length": 597,
        "protein_name": "mRNA-capping enzyme",
        "gene_name": "RNGTT",
        "organism": "Human",
        "refseq_name": "mRNA-capping enzyme isoform b",
        "refseq_ac": [
            {
                "id": "NP_001273355",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273355",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RNGTT; CAP1A",
        "gene_names_refseq": "CAP1A; HCE1; HCE; RNGTT; hCAP",
        "protein_names_uniprotkb": "mRNA-capping enzyme; GTP--RNA guanylyltransferase; GTase; HCAP1; HCE; mRNA 5'-phosphatase",
        "protein_names_refseq": "HCAP1; mRNA 5'-triphosphate monophosphatase; mRNA guanylyltransferase; mRNA-capping enzyme isoform b; mRNA-capping enzyme",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8732);  (R-HSA-167160);  (R-HSA-72086);  (R-HSA-77075)",
        "pathway_count": 4,
        "publication_count": 77,
        "publication_id_list": "10421630;11278368;15989964;17499042;18157150;19729311;19941815;20068231;21636784;22982363;23481700;24354960;25137142;25418920;25576301;25892735;26992070;27600516;27756891;27846572;27862975;27920218;28063628;28218747;28228285;28297668;28510447;28514659;28649982;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29605689;29632711;29786170;30410026;30429286;30524438;31217245;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33592498;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34509645;34561969;34932366;35051231;35580925;36010968;36241641;36284347;9371772;9473487;9512541;9705270;9790902",
        "class_list": "",
        "function": "Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate., [UniProtKB, PubMed, PubMed, PubMed]; C-Myc deregulation induces mRNA capping enzyme dependency in tumor cells., [RefSeq, PubMed]; These results identify a new domain of CE that is specific to its function in cytoplasmic capping, and a new role for Nck1 in regulating gene expression through its role as the scaffold for assembly of the cytoplasmic capping complex. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "E1P513;E1P514;O43483;O60257;O60351;Q5TCW8;Q8WUM8",
        "ec_number_list": [
            {
                "id": "2.7.7.50",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.50",
                "type": "external"
            },
            {
                "id": "3.6.1.74",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.74",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0005525 GTP binding;GO:0004721 phosphoprotein phosphatase activity;GO:0004651 polynucleotide 5'-phosphatase activity;GO:0004484 mRNA guanylyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006396 RNA processing;GO:0006370 7-methylguanosine mRNA capping",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "O60942-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95274-1",
        "uniprot_id": [
            {
                "id": "LYPD3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95274",
                "type": "external"
            }
        ],
        "mass": 35971.0,
        "length": 346,
        "protein_name": "Ly6/PLAUR domain-containing protein 3",
        "gene_name": "LYPD3",
        "organism": "Human",
        "refseq_name": "ly6/PLAUR domain-containing protein 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_055215",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055215",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LYPD3; C4.4A; PRO1007",
        "gene_names_refseq": "C4.4A; LYPD3",
        "protein_names_uniprotkb": "Ly6/PLAUR domain-containing protein 3; GPI-anchored metastasis-associated protein C4.4A homolog; MIG-C4; Matrigel-induced gene C4 protein",
        "protein_names_refseq": "2310061G07Rik; GPI-anchored metastasis-associated protein C4.4A homolog; GPI-anchored metastasis-associated protein homolog; MIG-C4; ly6/PLAUR domain-containing protein 3 precursor; ly6/PLAUR domain-containing protein 3; matrigel-induced gene C4 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27076);  (R-HSA-163125)",
        "pathway_count": 2,
        "publication_count": 24,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;11072085;11179665;11245483;12592373;12975309;15012588;20068231;23090970;23584533;24190977;2443973;24715725;25576301;29393594;29741879;31154438;32040344;32157095;33214551;3422494;37924160;39009906",
        "class_list": "",
        "function": "HAG-2 and hAG-3, human homologues of genes involved in differentiation, are associated with oestrogen receptor-positive breast tumours and interact with metastasis gene C4.4a and dystroglycan, [RefSeq, PubMed]; LY6/PLAUR domain containing 3 (LYPD3) maintains melanoma cell stemness and mediates an immunosuppressive microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]; M6A-dependent mature miR-151-5p accelerates the malignant process of HNSCC by targeting LYPD3. Publication Status: Online-Only, [RefSeq, PubMed]; Supports cell migration. May be involved in urothelial cell-matrix interactions. May be involved in tumor progression., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The authors explored the related pathways through which LYPD3 affects the pathogenesis and prognosis of lung adenocarcinoma by gene set enrichment analysis, and found that LYPD3 might affect the clinical manifestations of lung adenocarcinoma by regulating the P53 signaling pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 0,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UJ74",
        "ec_number_list": [],
        "go_molecular_function": "GO:0043236 laminin binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0098552 side of membrane",
        "go_biological_process": "GO:0034392 negative regulation of smooth muscle cell apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "O95274-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P08235-1",
        "uniprot_id": [
            {
                "id": "MCR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P08235",
                "type": "external"
            }
        ],
        "mass": 107082.0,
        "length": 984,
        "protein_name": "Mineralocorticoid receptor",
        "gene_name": "NR3C2",
        "organism": "Human",
        "refseq_name": "mineralocorticoid receptor isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000892",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000892",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NR3C2; MCR; MLR",
        "gene_names_refseq": "MCR; MLR; MR; NR3C2VIT; NR3C2",
        "protein_names_uniprotkb": "Mineralocorticoid receptor; MR; Nuclear receptor subfamily 3 group C member 2",
        "protein_names_refseq": "aldosterone receptor; mineralocorticoid receptor 1; mineralocorticoid receptor 2; mineralocorticoid receptor delta; mineralocorticoid receptor isoform 1",
        "tax_id": 9606,
        "disease": "fetal alcohol spectrum disorder (Disease Ontology:DOID:0050696); alcohol dependence (Disease Ontology:DOID:0050741); autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal dominant pseudohypoaldosteronism type 1 (Disease Ontology:DOID:0060855); opioid abuse (Disease Ontology:DOID:11206); polycystic ovary syndrome (Disease Ontology:DOID:11612); alcohol use disorder (Disease Ontology:DOID:1574); morphine dependence (Disease Ontology:DOID:2560); pseudohypoaldosteronism (Disease Ontology:DOID:4479); steatotic liver disease (Disease Ontology:DOID:9452); obesity (Disease Ontology:DOID:9970); pseudohyperaldosteronism type 2 (MONDO:MONDO:0011517)",
        "pathway": " (hsa:4306);  (R-HSA-3371497);  (R-HSA-4090294)",
        "pathway_count": 3,
        "publication_count": 138,
        "publication_id_list": "10391210;10747884;10760050;10884226;10935545;11121022;11134129;11350956;11518808;11589254;11701661;11751894;12077349;12144530;12177000;12483305;12781197;12788847;13486053;14500761;1493716;15159550;15192080;15192092;15381148;15456308;15591061;15908963;15923626;15961505;15967794;16061183;16403413;1655735;16912044;16954160;16959974;16972228;17020914;17105732;17218271;17314004;17591767;17717077;17804755;18215318;18243712;18254226;18635947;19029984;19041634;19211567;19359544;1939532;19692572;19850744;19864602;19955185;20006655;20038533;20072699;20159957;20357208;20719936;21158691;21183720;21376746;21467194;21700222;21796517;22011577;22266222;22318716;22433123;22791416;22930759;23546875;24012426;24206662;24694367;25114211;25188500;26073023;26203193;26313416;26992070;27462449;27663436;27862975;28083797;28301631;28755533;28832583;28834231;28919297;29127314;29242379;29557506;29789417;30197098;3037703;31110491;31141847;31731497;31826031;32016915;32157095;32320027;32448030;32544881;32938616;32982970;33141586;33968037;35051231;35254053;35318648;35580925;36229526;37130784;37175424;37541260;38054065;38127122;38255827;6645495;6891012;7495694;8157723;8282004;8560673;9141514;9392437;9464360;9464361;9662404;9667968;9724527",
        "class_list": "",
        "function": "Down-Regulation of the Mineralocorticoid Receptor (MR) and Up-Regulation of Hydroxysteroid 11-Beta Dehydrogenase Type 2 (HSD11B2) Isoenzyme in Critically Ill Patients., [RefSeq, PubMed]; Effects of environmental and genetic interactions on job burnout in coal miners: interactions between occupational stress, coping styles, and NR3C2 gene polymorphisms. Publication Status: Online-Only, [RefSeq, PubMed]; First Evidence of Mineralocorticoid Receptor Gene and Protein Expression in Rat and Human Thyroid Tissues and Cell Cultures. Publication Status: Online-Only, [RefSeq, PubMed]; Mineralocorticoid Receptor Antagonists for Preventing Chronic Kidney Disease Progression: Current Evidence and Future Challenges. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Mineralocorticoid receptor overactivation: targeting systemic impact with non-steroidal mineralocorticoid receptor antagonists. Review article, [RefSeq, PubMed]; Receptor for both mineralocorticoids (MC) such as aldosterone and glucocorticoids (GC) such as corticosterone or cortisol. Binds to mineralocorticoid response elements (MRE) and transactivates target genes. The effect of MC is to increase ion and water transport and thus raise extracellular fluid volume and blood pressure and lower potassium levels., [UniProtKB, PubMed]; This gene encodes the mineralocorticoid receptor, which mediates aldosterone actions on salt and water balance within restricted target cells. The protein functions as a ligand-dependent transcription factor that binds to mineralocorticoid response elements in order to transactivate target genes. Mutations in this gene cause autosomal dominant pseudohypoaldosteronism type I, a disorder characterized by urinary salt wasting. Defects in this gene are also associated with early onset hypertension with severe exacerbation in pregnancy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 23,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 12,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0ZBF5;B0ZBF7;Q2NKL1;Q96KQ8;Q96KQ9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0034056 estrogen response element binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0003707 nuclear steroid receptor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0043235 receptor complex;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0030518 nuclear receptor-mediated steroid hormone signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 14.5,
        "record_id": "P08235-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P14151-1",
        "uniprot_id": [
            {
                "id": "LYAM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P14151",
                "type": "external"
            }
        ],
        "mass": 42187.0,
        "length": 372,
        "protein_name": "L-selectin",
        "gene_name": "SELL",
        "organism": "Human",
        "refseq_name": "L-selectin precursor",
        "refseq_ac": [
            {
                "id": "NP_000646",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000646",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SELL; LNHR; LYAM1",
        "gene_names_refseq": "CD62L; LAM1; LECAM1; LEU8; LNHR; LSEL; LYAM1; PLNHR; SELL; TQ1",
        "protein_names_uniprotkb": "L-selectin; CD62 antigen-like family member L; LAM-1; LECAM1; Leukocyte adhesion molecule 1; Leukocyte surface antigen Leu-8; Leukocyte-endothelial cell adhesion molecule 1; Lymph node homing receptor; TQ1; gp90-MEL",
        "protein_names_refseq": "CD62 antigen-like family member L; L-selectin precursor; gp90-MEL; leukocyte surface antigen Leu-8; leukocyte-endothelial cell adhesion molecule 1; lymph node homing receptor; lymphocyte adhesion molecule 1; pln homing receptor",
        "tax_id": 9606,
        "disease": "stroke (Disease Ontology:DOID:0051061); colitis (Disease Ontology:DOID:0060180); graft-versus-host disease (Disease Ontology:DOID:0081267); Alzheimer's disease (Disease Ontology:DOID:10652); primary biliary cholangitis (Disease Ontology:DOID:12236); alcoholic hepatitis (Disease Ontology:DOID:12351); toxic shock syndrome (Disease Ontology:DOID:14115); alcohol use disorder (Disease Ontology:DOID:1574); hepatitis (Disease Ontology:DOID:2237); endometriosis (Disease Ontology:DOID:289); IgA glomerulonephritis (Disease Ontology:DOID:2986); peripheral vascular disease (Disease Ontology:DOID:341); pancreatitis (Disease Ontology:DOID:4989); ureteral obstruction (Disease Ontology:DOID:5199); abdominal aortic aneurysm (Disease Ontology:DOID:7693); end stage renal disease (Disease Ontology:DOID:783); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); systemic lupus erythematosus (Disease Ontology:DOID:9074); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:6402);  (R-HSA-198933);  (R-HSA-202733);  (R-HSA-6798695)",
        "pathway_count": 4,
        "publication_count": 205,
        "publication_id_list": "10499918;10606205;10746781;10764623;10918037;11207550;11237011;11256994;11265639;11489943;11513152;11556966;11564780;11779189;11807247;11812992;11857637;11858820;11861603;11955593;11955595;11955599;12070135;12208882;12213321;12403782;12469115;12483297;12588680;12736247;12782713;1375831;1376638;14529530;14615387;14702039;14719373;14970179;15000751;15034010;15136729;15155468;15187158;15304001;15528364;15534202;15541655;15580655;15607800;15681301;15721307;15778510;15781451;15800062;15851719;15864273;1591491;16014749;16091383;16129954;16258728;16297198;16335952;16339513;16380601;16551255;16585556;16691243;16710414;16737824;16737840;16754721;16783819;16893496;16904340;1692315;16928187;17045824;17057721;17064312;17099249;17116209;17167768;1717161;17172599;17237375;17322099;17337780;17379836;17442946;17452516;17505016;17525755;17563375;17580308;17600130;17615384;17625065;18031695;18037897;18055229;18209062;18234675;18593354;18606703;19149696;19279206;19349973;19359216;19592130;20730098;21193412;21241660;21659548;21800138;21841309;21850230;21877119;22299025;22396535;23650620;23695528;23929856;23945545;24043627;24190977;24305946;2473156;24764293;2509939;2538457;25418920;25576301;25703557;25716998;25775539;26154972;26284469;26300885;2663882;2664786;28011641;28218747;28228285;28489325;28904123;29242379;29314611;29437277;29493099;29557506;29632046;29632711;29741879;30315122;30429286;31154438;31217245;31608057;31844290;31998317;32350084;32433445;32983136;33091337;33408247;33482019;33537175;33633747;33728641;33936100;34357683;35154160;35458548;35580925;35702258;36828746;37074911;38060451;38065859;468991;7488174;7509040;7521878;7531291;7542404;7687382;8163559;8166770;8178173;8314844;8692836;8995416;9052782;9169774;9242610;9285412;9295288;9314561;9382878;9466983;9693095;9700512;9730896;9763524",
        "class_list": "glycogene",
        "function": "CD62L expression marks a functionally distinct subset of memory B cells., [RefSeq, PubMed]; Calcium-dependent lectin that mediates cell adhesion by binding to glycoproteins on neighboring cells (PubMed:12403782, PubMed:28011641, PubMed:28489325). Mediates the adherence of lymphocytes to endothelial cells of high endothelial venules in peripheral lymph nodes. Promotes initial tethering and rolling of leukocytes in endothelia (PubMed:12403782, PubMed:28011641)., [UniProtKB, PubMed, PubMed, PubMed]; Intercellular adhesion molecule 1 and selectin l play crucial roles in ulcerative colitis., [RefSeq, PubMed]; Intermediate Monocytes with PD-L1 and CD62L Expression as a Possible Player in Active SARS-CoV-2 Infection. Publication Status: Online-Only, [RefSeq, PubMed]; Sex-specific association of SELL gene polymorphisms with pattern hair loss in the Thai population: A candidate gene association study and in silico functional characterization., [RefSeq, PubMed]; The LINC00261/MiR105-5p/SELL axis is involved in dysfunction of B cell and is associated with overall survival in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a cell surface adhesion molecule that belongs to a family of adhesion/homing receptors. The encoded protein contains a C-type lectin-like domain, a calcium-binding epidermal growth factor-like domain, and two short complement-like repeats. The gene product is required for binding and subsequent rolling of leucocytes on endothelial cells, facilitating their migration into secondary lymphoid organs and inflammation sites. Single-nucleotide polymorphisms in this gene have been associated with various diseases including immunoglobulin A nephropathy. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 9,
        "reported_phosphosites": 2,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 424,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 52,
        "disease_count": 21,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A024R8Z0;B2R6Q8;P15023;Q9UJ43",
        "ec_number_list": [],
        "go_molecular_function": "GO:0043208 glycosphingolipid binding;GO:0070492 oligosaccharide binding;GO:0002020 protease binding;GO:0008201 heparin binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0030667 secretory granule membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007159 leukocyte cell-cell adhesion;GO:0034097 response to cytokine;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0050901 leukocyte tethering or rolling",
        "synthesized_glycan_count": 0,
        "hit_score": 26.2,
        "record_id": "P14151-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000010001.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P29966-1",
        "uniprot_id": [
            {
                "id": "MARCS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P29966",
                "type": "external"
            }
        ],
        "mass": 31555.0,
        "length": 332,
        "protein_name": "Myristoylated alanine-rich C-kinase substrate",
        "gene_name": "MARCKS",
        "organism": "Human",
        "refseq_name": "myristoylated alanine-rich C-kinase substrate",
        "refseq_ac": [
            {
                "id": "NP_002347",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002347",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MARCKS; MACS; PRKCSL",
        "gene_names_refseq": "80K-L; MACS; MARCKS; PKCSL; PRKCSL",
        "protein_names_uniprotkb": "Myristoylated alanine-rich C-kinase substrate; 80K-L protein; MARCKS; PKCSL; Protein kinase C substrate, 80 kDa protein, light chain",
        "protein_names_refseq": "myristoylated alanine-rich C-kinase substrate; myristoylated alanine-rich protein kinase C substrate (MARCKS, 80K-L); phosphomyristin; protein kinase C substrate, 80 kDa protein, light chain",
        "tax_id": 9606,
        "disease": "Lynch syndrome (Disease Ontology:DOID:3883)",
        "pathway": " (hsa:4082);  (R-HSA-399997)",
        "pathway_count": 2,
        "publication_count": 143,
        "publication_id_list": "10513815;11120772;11162562;11588141;11930178;12194018;1396720;1427823;14501149;14727513;15104674;1527003;15345747;15708490;16116087;16677610;16753580;16871065;17081983;17287340;17322306;17900700;17919190;17924679;18212344;18383439;18452278;18491316;18510355;18578522;1860846;18669648;18707149;18767875;19413330;19651622;19664994;19664995;20058876;20068231;20166139;2034276;2116001;21406692;21448919;22706990;23186163;23301498;23704996;23783831;24275569;24366607;24616531;2473066;25255805;25418920;25502872;25576301;25645385;26154972;26811146;26992070;27452731;27600516;27846572;27862975;27869121;27920218;28063628;28218747;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29557506;29632046;29632711;29786170;30225354;30315122;30410026;30429286;30444036;30779550;30833945;31154438;31530632;31611695;31844290;31848261;32033033;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33043033;33123756;33298915;33477989;33592498;33717175;33754052;33912179;33936100;33968037;33981976;34087483;34279157;34357683;34433824;34509657;34561969;35051231;35251023;35318648;35494241;35561310;35580925;36009319;36010968;36241641;36284347;36581221;37938771;37949888;38665916;38755678;39413095;7588787;7989336;8034575;8132675;8190105;8557118;9808756",
        "class_list": "",
        "function": "CircTRIM1 encodes TRIM1-269aa to promote chemoresistance and metastasis of TNBC via enhancing CaM-dependent MARCKS translocation and PI3K/AKT/mTOR activation. Publication Status: Online-Only, [RefSeq, PubMed]; MARCKS cooperates with NKAP to activate NF-kB signaling in smoke-related lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; MARCKS on Tumor-Associated Macrophages is Correlated with Immune Infiltrates and Poor Prognosis in Hepatocellular Carcinoma., [RefSeq, PubMed]; Membrane-associated protein that plays a role in the structural modulation of the actin cytoskeleton, chemotaxis, motility, cell adhesion, phagocytosis, and exocytosis through lipid sequestering and/or protein docking to membranes (PubMed:23704996, PubMed:36009319). Thus, exerts an influence on a plethora of physiological processes, such as embryonic development, tissue regeneration, neuronal plasticity, and inflammation. Sequesters phosphatidylinositol 4,5-bisphosphate (PIP2) at lipid rafts in the plasma membrane of quiescent cells, an action reversed by protein kinase C, ultimately inhibiting exocytosis (PubMed:23704996). During inflammation, promotes the migration and adhesion of inflammatory cells and the secretion of cytokines such as tumor necrosis factor (TNF), particularly in macrophages (PubMed:37949888). Plays an essential role in bacteria-induced intracellular reactive oxygen species (ROS) formation in the monocytic cell type. Participates in the regulation of neurite initiation and outgrowth by interacting with components of cellular machinery including CDC42 that regulates cell shape and process extension through modulation of the cytoskeleton (By similarity). Plays also a role in axon development by mediating docking and fusion of RAB10-positive vesicles with the plasma membrane (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Mycobacterium avium inhibits protein kinase C and MARCKS phosphorylation in human cystic fibrosis and non-cystic fibrosis cells. Publication Status: Online-Only, [RefSeq, PubMed]; The myristoylated alanine-rich C-kinase substrates (MARCKS): A membrane-anchored mediator of the cell function. Review article, [RefSeq, PubMed]; The protein encoded by this gene is a substrate for protein kinase C. It is localized to the plasma membrane and is an actin filament crosslinking protein. Phosphorylation by protein kinase C or binding to calcium-calmodulin inhibits its association with actin and with the plasma membrane, leading to its presence in the cytoplasm. The protein is thought to be involved in cell motility, phagocytosis, membrane trafficking and mitogenesis. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 42,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P560;Q2LA83;Q5TDB7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0005080 protein kinase C binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005886 plasma membrane;GO:0005925 focal adhesion;GO:0005938 cell cortex",
        "go_biological_process": "GO:0007015 actin filament organization;GO:0006915 apoptotic process;GO:0007417 central nervous system development;GO:0051017 actin filament bundle assembly;GO:0021915 neural tube development",
        "synthesized_glycan_count": 0,
        "hit_score": 14.6,
        "record_id": "P29966-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P43359-1",
        "uniprot_id": [
            {
                "id": "MAGA5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P43359",
                "type": "external"
            }
        ],
        "mass": 13016.0,
        "length": 124,
        "protein_name": "Putative melanoma-associated antigen 5P",
        "gene_name": "MAGEA5P",
        "organism": "Human",
        "refseq_name": "putative melanoma-associated antigen 5P",
        "refseq_ac": [
            {
                "id": "NP_001191740",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191740",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAGEA5P; MAGE5; MAGEA5",
        "gene_names_refseq": "LOC100533997; MAGEA10-MAGEA5",
        "protein_names_uniprotkb": "Putative melanoma-associated antigen 5P; CT1.5; Cancer/testis antigen 1.5; MAGE family member A5 pseudogene; MAGE-5 antigen",
        "protein_names_refseq": "putative melanoma-associated antigen 5P",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100533997)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "17942928;27893789;30484775;31844290;34290406;7927540",
        "class_list": "",
        "function": "May negatively regulates apoptosis., [UniProtKB, PubMed]; This locus represents naturally occurring read-through transcription between the neighboring MAGEA10 (melanoma antigen family A, 10) and MAGEA5 (melanoma antigen family A, 5) genes on chromosome X. The read-through transcript is predicted to encode the downstream gene product. [provided by RefSeq, Mar 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q32MD0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0051983 regulation of chromosome segregation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "P43359-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16655-1",
        "uniprot_id": [
            {
                "id": "MAR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16655",
                "type": "external"
            }
        ],
        "mass": 13157.0,
        "length": 118,
        "protein_name": "Melanoma antigen recognized by T-cells 1",
        "gene_name": "MLANA",
        "organism": "Human",
        "refseq_name": "melanoma antigen recognized by T-cells 1",
        "refseq_ac": [
            {
                "id": "NP_005502",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005502",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MLANA; MART1",
        "gene_names_refseq": "MART-1; MART1; MLANA",
        "protein_names_uniprotkb": "Melanoma antigen recognized by T-cells 1; Antigen LB39-AA; Antigen SK29-AA; MART-1; Protein Melan-A",
        "protein_names_refseq": "antigen LB39-AA; antigen SK29-AA; epididymis secretory sperm binding protein; melanoma antigen recognized by T-cells 1; protein Melan-A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2315);  (R-HSA-9824585)",
        "pathway_count": 2,
        "publication_count": 124,
        "publication_id_list": "10540322;10587587;10916751;10958352;11532965;11551907;11684128;11854361;11856727;11886495;11964381;12062444;12072203;12119345;12191019;12394191;1321344;14609574;15336780;1537333;1537334;15543135;15695408;15695812;15723046;15729346;16197958;16303920;16455990;16462803;17056587;17182843;17559180;17719062;17952075;18424733;18483556;18697795;18812475;18942640;19389701;19717472;19786555;20417641;20639478;21093097;21795600;21937447;22952231;23954306;24267888;24550723;24987109;25311806;25471691;25525252;25645385;25875651;25992863;26002978;26079729;26500235;26694611;26808500;27317354;27504122;27600516;27869121;27872103;28489076;28536308;28724801;29305520;29485866;29933102;30008714;30219821;30515787;30617019;30700902;30700903;30778347;30850685;30930889;31015344;31091334;31324690;31555299;31969886;32157095;32184297;32241816;32314731;32363124;32488085;32582212;32913893;32983136;33100333;34290406;35132961;35508657;35580127;35874702;36032094;36593398;36608422;36669074;37280206;37300490;37490916;37586765;37989630;38205829;38653798;39394480;7813420;8006593;8170938;8306979;8921401;9185691;9545200;9758418",
        "class_list": "",
        "function": "Expression of Melan-A in cutaneous granular cell tumours: a diagnostic pitfall., [RefSeq, PubMed]; Involved in melanosome biogenesis by ensuring the stability of GPR143. Plays a vital role in the expression, stability, trafficking, and processing of melanocyte protein PMEL, which is critical to the formation of stage II melanosomes., [UniProtKB, PubMed, PubMed]; Melan-A expression in non-melanocytic carcinoma: A potential diagnostic pitfall., [RefSeq, PubMed]; Melanosomes from an Achilles tendon clear-cell sarcoma showed expression of the Melan-A gene., [RefSeq, PubMed]; Staged Excision of Lentigo Maligna of the Head and Neck: Assessing Surgical Excision Margins With Melan A, SOX10, and PRAME Immunohistochemistry., [RefSeq, PubMed]; The high frequency of Melan-A multimer(+) T cells can be explained by the existence of largely cross-reactive subsets of naive CD8(+) T cells displaying multiple specificities., [RefSeq, PubMed]; Unexpected high frequency of T cells specific for the self-antigen Melan-A/MART-1 in CD8 single-positive thymocytes from human histocompatibility leukocyte antigen-A2 healthy individuals, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ICU4",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0042470 melanosome;GO:0005802 trans-Golgi network",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 12.7,
        "record_id": "Q16655-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16706-1",
        "uniprot_id": [
            {
                "id": "MA2A1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16706",
                "type": "external"
            }
        ],
        "mass": 131141.0,
        "length": 1144,
        "protein_name": "Alpha-mannosidase 2",
        "gene_name": "MAN2A1",
        "organism": "Human",
        "refseq_name": "alpha-mannosidase 2",
        "refseq_ac": [
            {
                "id": "NP_002363",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002363",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAN2A1; MANA2",
        "gene_names_refseq": "AMan II; GOLIM7; MAN2A1; MANA2; MANII",
        "protein_names_uniprotkb": "Alpha-mannosidase 2; 3.2.1.114; AMan II; Golgi alpha-mannosidase II; Man II; Mannosidase alpha class 2A member 1; Mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase",
        "protein_names_refseq": "Golgi alpha-mannosidase II; alpha-mannosidase 2; golgi integral membrane protein 7; mannosidase, alpha type II; mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase",
        "tax_id": 9606,
        "disease": "congenital dyserythropoietic anemia (Disease Ontology:DOID:1338); systemic lupus erythematosus (Disease Ontology:DOID:9074)",
        "pathway": " (hsa:4124);  (R-HSA-6811438);  (R-HSA-9694548);  (R-HSA-975578)",
        "pathway_count": 4,
        "publication_count": 132,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10094192;10189370;10343104;10464296;10652308;10652516;10814706;10988300;11445554;11718716;11748249;12011112;12383348;12417412;12429822;15504911;15718469;15728195;15758030;16335952;16754854;17175120;17274799;17466984;18086915;18256213;18431515;18451304;19164740;19536132;19715559;20163571;20166139;20874812;21807881;22013193;22188167;22915798;23091056;23239882;23378023;23462996;23584533;23839779;23936529;23940353;24119662;24190977;24275569;25502872;25576301;25708460;25787250;25813380;25880248;26375851;26758079;26992070;27035259;27846572;28245430;28467828;28904123;29317506;29391424;29437277;29557506;30315122;30429286;30573663;30833945;31020640;31154438;31217245;31611695;31844290;31848261;32157095;32161166;32350084;32357974;32363391;32366695;32387766;32403105;32518941;32676595;32723834;32938616;32983136;33298915;33310888;33592498;33912179;33936100;33968037;33981976;34087483;34117209;34357683;34428449;34528721;34599882;34932366;34961524;35051231;35154160;35251023;35580925;36010968;36241641;36280670;37074911;37340703;7635144;7650030;7986008;8524845;8636227;8808595;8945478;9244307;9476900;9478973;9510256;9653114;9707577;9915833;9949196",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "Catalyzes the first committed step in the biosynthesis of complex N-glycans. It controls conversion of high mannose to complex N-glycans; the final hydrolytic step in the N-glycan maturation pathway., [UniProtKB, UniProtKB, PubMed]; Golgi Alpha-Mannosidase II as a Novel Biomarker Predicts Prognosis in Clear Cell Renal Cell Carcinoma., [RefSeq, PubMed]; He QSAR models with the fragmented QM-DFT descriptors may find a useful application in structure-based drug design where pure empirical and force field methods reached their limits and where quantum mechanics effects are critical for ligand-receptor interactions. The optimized models will apply in lead optimization processes for GMII drug developments., [RefSeq, PubMed]; Inhibition of MAN2A1 Enhances the Immune Response to Anti-PD-L1 in Human Tumors., [RefSeq, PubMed]; Many human tumor types and cancer cell lines express the MAN2A1-FER fusion, which increases proliferation and invasiveness of cancer cell lines and has liver oncogenic activity in mice., [RefSeq, PubMed]; This gene encodes a glycosyl hydrolase that localizes to the Golgi and catalyzes the final hydrolytic step in the asparagine-linked oligosaccharide (N-glycan) maturation pathway. Mutations in the mouse homolog of this gene have been shown to cause a systemic autoimmune disease similar to human systemic lupus erythematosus. [provided by RefSeq, Dec 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1329,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 15,
        "disease_count": 2,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16767",
        "ec_number_list": [
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.113",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.113",
                "type": "external"
            },
            {
                "id": "2.4.1.101",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.101",
                "type": "external"
            },
            {
                "id": "3.2.1.114",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.114",
                "type": "external"
            },
            {
                "id": "2.4.1.143",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.143",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding;GO:0004559 alpha-mannosidase activity;GO:0016799 hydrolase activity, hydrolyzing N-glycosyl compounds;GO:0004572 mannosyl-oligosaccharide 1,3-1,6-alpha-mannosidase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0005797 Golgi medial cisterna",
        "go_biological_process": "GO:0019082 viral protein processing;GO:0006491 N-glycan processing;GO:0006013 mannose metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 15.5,
        "record_id": "Q16706-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000010001.101.10100",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5BKY1-1",
        "uniprot_id": [
            {
                "id": "LRC10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5BKY1",
                "type": "external"
            }
        ],
        "mass": 31642.0,
        "length": 277,
        "protein_name": "Leucine-rich repeat-containing protein 10",
        "gene_name": "LRRC10",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 10",
        "refseq_ac": [
            {
                "id": "NP_963844",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_963844",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC10",
        "gene_names_refseq": "HRLRRP; LRRC10A; LRRC10",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 10",
        "protein_names_refseq": "heart-restricted leucine-rich repeat protein; leucine-rich repeat-containing protein 10",
        "tax_id": 9606,
        "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930)",
        "pathway": " (hsa:376132)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "26017719;28032242;29431102;35051231;38762910",
        "class_list": "",
        "function": "Cardiac L-type calcium channel regulation by Leucine-Rich Repeat-Containing Protein 10. Review article, [RefSeq, PubMed]; Examination of a patient with dilated cardiomyopathy revealed homozygosity for a previously unreported LRRC10 variant: I195T. Wild-type and I195T LRRC10 function as cardiac-specific subunits of L-type Ca(2+) channels and exert dramatically different effects on channel gating, providing a potential link to DCM. Publication Status: Online-Only, [RefSeq, PubMed]; LRRC10 may be a new susceptible gene for Sudden unexplained nocturnal death syndrome, and LRRC10 variant was initially and genetically linked to Brugada syndrome associated arrhythmia., [RefSeq, PubMed]; May play important roles in cardiac development and/or cardiac function., [UniProtKB]; This study firstly reports the association of LRRC10 mutations with enhanced susceptibility to dilated cardiomyopathy in humans., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "total_o_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "missing_score": 10000,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ZVY4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0051393 alpha-actinin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005856 cytoskeleton;GO:0030017 sarcomere",
        "go_biological_process": "GO:0055013 cardiac muscle cell development",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q5BKY1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z4W2-1",
        "uniprot_id": [
            {
                "id": "LYZL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z4W2",
                "type": "external"
            }
        ],
        "mass": 16656.0,
        "length": 148,
        "protein_name": "Lysozyme-like protein 2",
        "gene_name": "LYZL2",
        "organism": "Human",
        "refseq_name": "lysozyme-like protein 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_898881",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_898881",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LYZL2",
        "gene_names_refseq": "LYZD2; LYZL2",
        "protein_names_uniprotkb": "Lysozyme-like protein 2; 3.2.1.17; Lysozyme-2",
        "protein_names_refseq": "lysozyme D2; lysozyme-2; lysozyme-like protein 2 precursor; lysozyme-like protein 2",
        "tax_id": 9606,
        "disease": "viral infectious disease (Disease Ontology:DOID:934)",
        "pathway": " (hsa:119180)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "16014814;18984674;23064961",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "Lysozymes (see LYZ; MIM 153450), especially C-type lysozymes, are well-recognized bacteriolytic factors widely distributed in the animal kingdom and play a mainly protective role in host defense. LYZL2 is a member of a family of lysozyme-like genes (Zhang et al., 2005 [PubMed 16014814]).[supplied by OMIM, Apr 2009]., [RefSeq]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; We identified a significant genetic association between dental caries of the anterior mandibular teeth and LYZL2 (p value = 9e-9), which codes a bacteriolytic agent thought to be involved in host defense., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_snv": 242,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NZ69",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003796 lysozyme activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q7Z4W2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.10100",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86YJ5-1",
        "uniprot_id": [
            {
                "id": "MARH9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86YJ5",
                "type": "external"
            }
        ],
        "mass": 37772.0,
        "length": 346,
        "protein_name": "E3 ubiquitin-protein ligase MARCHF9",
        "gene_name": "MARCHF9",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase MARCHF9",
        "refseq_ac": [
            {
                "id": "NP_612405",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612405",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MARCHF9; MARCH9; RNF179",
        "gene_names_refseq": "MARCH-IX; MARCH9; MARCHF9; RNF179",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF9; 2.3.2.27; MARCH-IX; Membrane-associated RING finger protein 9; Membrane-associated RING-CH protein IX; RING finger protein 179; RING-type E3 ubiquitin transferase MARCHF9",
        "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH9; E3 ubiquitin-protein ligase MARCHF9; RING finger protein 179; RING-type E3 ubiquitin transferase MARCH9; RING-type E3 ubiquitin transferase MARCHF9; membrane associated ring finger 9; membrane-associated RING finger protein 9; membrane-associated RING-CH protein IX; membrane-associated ring finger (C3HC4) 9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92979)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "14722266;17174307;19913121;20628086;20870941;25502872;28832583;29921698;30278450;30554144;31844290;32157095;32983136;33912179;34087483;34357683;34561969;35051231;35154160;35561310;39185021",
        "class_list": "",
        "function": "Analysis of glioblastoma alterations such as IDH mutation, NF1 inactivation, and CDK4-MARCH9 locus amplification, [RefSeq, PubMed]; Biochemical and structural findings demonstrate that specific sequences in the alpha-helical MARCH9 TM domains make crucial contributions to its ability to down-regulate its protein substrates., [RefSeq, PubMed]; Downregulation of Mult1 by MARCH9 was reversed by heat-shock treatment, which resulted in the dissociation of the two proteins and increased the amount of Mult1 at the cell surface., [RefSeq, PubMed]; E3 ubiquitin-protein ligase that may mediate ubiquitination of MHC-I, CD4 and ICAM1, and promote their subsequent endocytosis and sorting to lysosomes via multivesicular bodies. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., [UniProtKB, PubMed, PubMed]; Investigating the Prognostic and Oncogenic Roles of Membrane-Associated Ring-CH-Type Finger 9 in Colorectal Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; MARCH-IX expression causes ubiquitination and downregulation of ICAM-1, [RefSeq, PubMed]; MARCH9 is a member of the MARCH family of membrane-bound E3 ubiquitin ligases (EC 6.3.2.19). MARCH enzymes add ubiquitin (see MIM 191339) to target lysines in substrate proteins, thereby signaling their vesicular transport between membrane compartments. MARCH9 induces internalization of several membrane glycoproteins and directs them to the endosomal compartment (Bartee et al., 2004 [PubMed 14722266]; Hoer et al., 2007 [PubMed 17174307]).[supplied by OMIM, Apr 2010]., [RefSeq]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Overexpression of MARCH9 was found to attenuate the oncogenic effect of ICAM-1, suggesting that MARCH9 may inhibit tumor progression by downregulating ICAM-1 signaling., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9U9;Q86VN5;Q96GG2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005765 lysosomal membrane;GO:0005795 Golgi stack;GO:0005802 trans-Golgi network",
        "go_biological_process": "GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q86YJ5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TD90-1",
        "uniprot_id": [
            {
                "id": "MAGE2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TD90",
                "type": "external"
            }
        ],
        "mass": 60378.0,
        "length": 523,
        "protein_name": "Melanoma-associated antigen E2",
        "gene_name": "MAGEE2",
        "organism": "Human",
        "refseq_name": "melanoma-associated antigen E2",
        "refseq_ac": [
            {
                "id": "NP_619648",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619648",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAGEE2; HCA3",
        "gene_names_refseq": "HCA3; MAGEE2",
        "protein_names_uniprotkb": "Melanoma-associated antigen E2; Hepatocellular carcinoma-associated protein 3; MAGE-E2 antigen",
        "protein_names_refseq": "MAGE-E2 antigen; hepatocellular carcinoma-associated protein 3; hepatocellular carcinoma-associated protein HCA3; melanoma antigen family E, 2; melanoma antigen family E2; melanoma-associated antigen E2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:139599)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "29508533;30429286;35580925;37938771",
        "class_list": "",
        "function": "This gene encodes a member of the E subfamily of MAGE (melanoma antigen-encoding gene) gene family. The gene is intronless and the encoded protein has two of the MAGE domains which are characteristic of MAGE family proteins. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "Q5JSI5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q8TD90-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TD91-1",
        "uniprot_id": [
            {
                "id": "MAGC3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TD91",
                "type": "external"
            }
        ],
        "mass": 71909.0,
        "length": 643,
        "protein_name": "Melanoma-associated antigen C3",
        "gene_name": "MAGEC3",
        "organism": "Human",
        "refseq_name": "melanoma-associated antigen C3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_619647",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619647",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAGEC3; HCA2",
        "gene_names_refseq": "CT7.2; HCA2; MAGE-C3; MAGEC3; MAGEC4",
        "protein_names_uniprotkb": "Melanoma-associated antigen C3; CT7.2; Cancer/testis antigen 7.2; Hepatocellular carcinoma-associated antigen 2; MAGE-C3 antigen",
        "protein_names_refseq": "MAGE family testis and tumor-specific protein; MAGE-C3 antigen; cancer/testis antigen 7.2; cancer/testis antigen family 7, member 2; hepatocellular carcinoma-associated antigen 2; hepatocellular carcinoma-associated protein HCA2; melanoma antigen family C, 3; melanoma antigen family C3; melanoma-associated antigen C3 isoform 1; melanoma-associated antigen C3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:139081)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "10861452;18318008;26857816;31273921;32488085;32938616;35051231;37340703",
        "class_list": "",
        "function": "Nicotinic acid suppresses sebaceous lipogenesis of human sebocytes via activating hydroxycarboxylic acid receptor 2 (HCA2 )., [RefSeq, PubMed]; The data support an important role for prostaglandin activation of sAC and PKA in H2O2-induced barrier disruption. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the MAGEC gene family. The members of this family are not expressed in normal tissues, except for testis, and are expressed in tumors of various histological types. The MAGEC genes are clustered on chromosome Xq26-q27. Two transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
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        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
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        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3SYA7;Q5JZ43;Q9BZ80",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8TD91-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92585-1",
        "uniprot_id": [
            {
                "id": "MAML1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92585",
                "type": "external"
            }
        ],
        "mass": 108054.0,
        "length": 1016,
        "protein_name": "Mastermind-like protein 1",
        "gene_name": "MAML1",
        "organism": "Human",
        "refseq_name": "mastermind-like protein 1",
        "refseq_ac": [
            {
                "id": "NP_055572",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055572",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAML1; KIAA0200",
        "gene_names_refseq": "MAML1; Mam-1; Mam1",
        "protein_names_uniprotkb": "Mastermind-like protein 1; Mam-1",
        "protein_names_refseq": "mastermind homolog; mastermind-like 1; mastermind-like protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9794);  (R-HSA-1912408);  (R-HSA-210744);  (R-HSA-2122947);  (R-HSA-2197563);  (R-HSA-2644606);  (R-HSA-2894862);  (R-HSA-350054);  (R-HSA-8941856);  (R-HSA-9013508);  (R-HSA-9013695);  (R-HSA-9793380);  (R-HSA-9976102)",
        "pathway_count": 13,
        "publication_count": 184,
        "publication_id_list": "10206645;10713164;10879540;10882063;10964718;11006133;11044625;11101851;11112321;11390662;11461910;11585921;11740940;11866432;11986231;12050117;12209127;12354787;12374742;12386158;12391150;12530964;14672936;14980219;14991602;15107403;15472075;15531924;15546612;15574878;15684396;15760269;15824097;15829515;16093323;16256737;16530044;16530045;16612405;16738328;16751179;17003037;17114293;17157496;17284587;17317671;17344417;17401372;17540598;17540599;17554337;17646408;17646409;17685488;17823410;18043734;18077452;18094723;18239137;18296446;1831692;18374649;18724371;18824583;18824585;18974129;19150886;19151708;19524514;19608861;19664994;19690332;19714243;19723635;19726682;19773441;19800882;20080834;20090754;20351093;20442293;20442780;20495621;20801121;20804727;20805998;20972443;21280156;21402699;21551231;21602795;21637926;21875955;22110129;22396495;23186163;23301498;23481700;24366607;24715725;25417103;25505266;26154972;26387946;26801977;26977885;26992070;27749937;27841855;27846572;27920218;28178531;28218747;28446606;28649982;28832583;28834231;28904123;29101237;29146722;29242379;29393594;29437277;29508533;29557506;29632711;30059200;30429286;30524438;31092671;31492838;31844290;31998317;32157095;32180088;32357974;32387766;32482852;32488085;32502341;32897882;32938616;32983136;33214551;33298915;33592498;33691108;33936100;33968037;34019948;34087483;34171305;34509645;34818576;34932366;35051231;35132862;35138101;35254053;35513511;35580925;36010968;36155393;36241641;36284347;38253038;38665916;39531497;39534244;7566092;7588063;8001118;8649374;8687460;8878478;9244301;9315665;9462510;9604939;9620803;9651681;9693032;9694793;9819428",
        "class_list": "",
        "function": "Acts as a transcriptional coactivator for NOTCH proteins. Has been shown to amplify NOTCH-induced transcription of HES1. Enhances phosphorylation and proteolytic turnover of the NOTCH intracellular domain in the nucleus through interaction with CDK8. Binds to CREBBP/CBP which promotes nucleosome acetylation at NOTCH enhancers and activates transcription. Induces phosphorylation and localization of CREBBP to nuclear foci. Plays a role in hematopoietic development by regulating NOTCH-mediated lymphoid cell fate decisions., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Cottontail rabbit papillomavirus E6 proteins: Interaction with MAML1 and modulation of the Notch signaling pathway., [RefSeq, PubMed]; Elucidated tumorigenic role of MAML1 and TWIST1 in gastric cancer is associated with Helicobacter pylori infection., [RefSeq, PubMed]; MAML1 promotes ESCC aggressiveness through upregulation of EMT marker TWIST1., [RefSeq, PubMed]; MAML1/2 promote YAP/TAZ nuclear localization and tumorigenesis., [RefSeq, PubMed]; Mastermind mediates chromatin-specific transcription and turnover of the Notch enhancer complex, [RefSeq, PubMed]; This protein is the human homolog of mastermind, a Drosophila protein that plays a role in the Notch signaling pathway involved in cell-fate determination. There is in vitro evidence that the human homolog forms a complex with the intracellular portion of human Notch receptors and can increase expression of a Notch-induced gene. This evidence supports its proposed function as a transcriptional co-activator in the Notch signaling pathway. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 13,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 13,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 13,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 43,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NZ12",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0019901 protein kinase binding;GO:0042605 peptide antigen binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0002193 MAML1-RBP-Jkappa- ICN1 complex",
        "go_biological_process": "GO:0010831 positive regulation of myotube differentiation;GO:0006351 DNA-templated transcription;GO:0006468 protein phosphorylation;GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 19.9,
        "record_id": "Q92585-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q969V1-1",
        "uniprot_id": [
            {
                "id": "MCHR2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q969V1",
                "type": "external"
            }
        ],
        "mass": 38849.0,
        "length": 340,
        "protein_name": "Melanin-concentrating hormone receptor 2",
        "gene_name": "MCHR2",
        "organism": "Human",
        "refseq_name": "melanin-concentrating hormone receptor 2",
        "refseq_ac": [
            {
                "id": "NP_001035269",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035269",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MCHR2; GPR145; SLT",
        "gene_names_refseq": "GPR145; GPRv17; MCH-2R; MCH-R2; MCH2R; MCH2; MCHR-2; MCHR2; SLT",
        "protein_names_uniprotkb": "Melanin-concentrating hormone receptor 2; G protein-coupled receptor 145; GPRv17; MCH receptor 2; MCH-2R; MCH-R2; MCH2R; MCH2; MCHR-2",
        "protein_names_refseq": "G protein-coupled receptor slt; G-protein coupled receptor 145; MCH receptor 2; melanin-concentrating hormone 2; melanin-concentrating hormone receptor 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84539);  (R-HSA-375276);  (R-HSA-416476);  (R-HSA-418594)",
        "pathway_count": 4,
        "publication_count": 133,
        "publication_id_list": "10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10899166;11007482;11015615;11274220;11322507;11355873;11385580;11404457;11457843;11459838;11562423;11683476;11742120;11753430;11773063;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15340116;15539556;1567413;15947423;15951850;16182515;16268778;16339447;1655761;16634148;16754659;16923326;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18515384;18577758;18936096;1905813;23446738;23690594;24906252;2534964;26461262;2649896;27306922;2748346;27496565;2834384;2841328;29066024;3086311;3202875;3366244;3525564;3856870;38710677;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8015379;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8406495;8440682;8463333;8503909;8615752;8664309;8666380;8702752;873923;8823230;9171878;9305846;9521323;9530155;9593744;9607765;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "Evidence for the involvement of duplications in MCHR2 in alopecia areata pathogenesis in a Central European cohort, [RefSeq, PubMed]; G protein-coupled receptor for the neuropeptide melanin-concentrating hormone (MCH). Upon ligand binding, couples to G(q/11), leading to activation of phospholipase C and intracellular calcium mobilization (PubMed:11274220, PubMed:11404457, PubMed:11459838, PubMed:15340116, PubMed:38710677). The physiological roles mediated by this receptor remain unclear, and its contribution to specific biological processes has not been conclusively established (Probable). Expression of this receptor is restricted to the brain of non-rodent mammals; a functional MCHR2 gene is absent or pseudogenized in rodents (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Results are in line with some previously performed studies suggesting that MCHR2 is not a major contributor to human obesity and the Prader Willi Syndrome phenotype, [RefSeq, PubMed]; This study provides new insights on the possible influence of MCHR2 and/or MCHR2-AS1 on obesity in psychiatric patients and on the pathophysiology of atypical depression. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KVW4;E1P5D7;Q5VTV7;Q6Q377;Q9BXA8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004966 galanin receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007218 neuropeptide signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 13.4,
        "record_id": "Q969V1-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96CX6-1",
        "uniprot_id": [
            {
                "id": "LRC58_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96CX6",
                "type": "external"
            }
        ],
        "mass": 40586.0,
        "length": 371,
        "protein_name": "Leucine-rich repeat-containing protein 58",
        "gene_name": "LRRC58",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 58",
        "refseq_ac": [
            {
                "id": "NP_001093148",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093148",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC58",
        "gene_names_refseq": "LRRC58",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 58",
        "protein_names_refseq": "leucine-rich repeat-containing protein 58",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:116064)",
        "pathway_count": 1,
        "publication_count": 67,
        "publication_id_list": "18446792;19690332;22299025;23481700;24366607;24714562;24715725;25418920;25505266;25576301;25645385;26154972;26375851;26728094;26992070;27397612;27846572;27920218;28218747;28228285;28411811;28832583;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29786170;30315122;30429286;31154438;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33633747;33912179;33936100;33968037;33981976;34211107;34509645;34561969;34932366;35051231;35154160;35318648;36010968;36284347;40914422;40963025",
        "class_list": "",
        "function": "Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CDO1 (PubMed:40963025). The ECS(LRRC58) complex acts as a regulator of cysteine catabolism by mediating ubiquitination and degradation of CDO1, the rate-limiting enzyme of the cysteine catabolic process to taurine (PubMed:40963025). L-cysteine abundance regulates ECS(LRRC58)-mediated ubiquitination of CDO1: the complex promotes ubiquitination and degradation of CDO1 in presence of high level of cysteine, but not when cysteine abundance is low (PubMed:40963025)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0031466 Cul5-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0062089 regulation of taurine biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q96CX6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96DD0-1",
        "uniprot_id": [
            {
                "id": "LRC39_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96DD0",
                "type": "external"
            }
        ],
        "mass": 38793.0,
        "length": 335,
        "protein_name": "Leucine-rich repeat-containing protein 39",
        "gene_name": "LRRC39",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat-containing protein 39 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001243314",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243314",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRC39; PRO21368",
        "gene_names_refseq": "LRRC39",
        "protein_names_uniprotkb": "Leucine-rich repeat-containing protein 39; Myomasp; Myosin-interacting M-band-associated stress-responsive protein",
        "protein_names_refseq": "densin hlg; leucine-rich repeat-containing protein 39 isoform 1; leucine-rich repeat-containing protein 39; myomasp; myosin-interacting M-band-associated stress-responsive protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:127495)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "12975309;20847312;35051231;36241641",
        "class_list": "",
        "function": "Component of the sarcomeric M-band which plays a role in myocyte response to biomechanical stress. May regulate expression of other M-band proteins via an SRF-dependent pathway. Important for normal contractile function in heart., [UniProtKB, UniProtKB]; Reveal myomasp/LRRC39 as a previously unrecognized component of an M-band-associated signaling pathway that regulates cardiomyocyte gene expression in response to biomechanical stress., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
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        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KUD2;D3DT56;Q5VVK7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0031430 M band",
        "go_biological_process": "GO:0035556 intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q96DD0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96JE9-1",
        "uniprot_id": [
            {
                "id": "MAP6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96JE9",
                "type": "external"
            }
        ],
        "mass": 86505.0,
        "length": 813,
        "protein_name": "Microtubule-associated protein 6",
        "gene_name": "MAP6",
        "organism": "Human",
        "refseq_name": "microtubule-associated protein 6 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_149052",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_149052",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAP6; KIAA1878",
        "gene_names_refseq": "MAP6-N; MAP6; MTAP6; N-STOP; STOP",
        "protein_names_uniprotkb": "Microtubule-associated protein 6; MAP-6; STOP; Stable tubule-only polypeptide",
        "protein_names_refseq": "CTD-2530H12.7; MAP-6; microtubule-associated protein 6 isoform 1; stable tubule-only polypeptide",
        "tax_id": 9606,
        "disease": "schizophrenia (Disease Ontology:DOID:5419)",
        "pathway": " (hsa:4135)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "14692697;16624526;18510355;23831686;24357581;26198635;27541346;28657654;29557506;30379171;30429286;31844290;35051231;36010968;36088616",
        "class_list": "",
        "function": "Involved in microtubule stabilization in many cell types, including neuronal cells (By similarity). Specifically has microtubule cold stabilizing activity (By similarity). Involved in dendrite morphogenesis and maintenance by regulating lysosomal trafficking via its interaction with TMEM106B (PubMed:24357581). Regulates KIF5A-mediated axonal cargo transport (By similarity). Regulates axonal growth during neuron polarization (By similarity)., [UniProtKB, PubMed, UniProtKB]; SPOP Mutations as a Predictive Biomarker for Androgen Receptor Axis-Targeted Therapy in De Novo Metastatic Castration-Sensitive Prostate Cancer., [RefSeq, PubMed]; Structural basis for the association of MAP6 protein with microtubules and its regulation by calmodulin., [RefSeq, PubMed]; The concentration of STOP/MAP6 protein was significantly reduced in the plasma of autistic subjects than that in healthy controls., [RefSeq, PubMed]; These data show that TMEM106B/MAP6 interaction is crucial for controlling dendritic trafficking of lysosomes, presumably by acting as a molecular brake for retrograde transport., [RefSeq, PubMed]; This gene encodes a microtubule-associated protein. The encoded protein is a calmodulin-binding and calmodulin-regulated protein that is involved in microtubule stabilization. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "secondary_ac_list": "A7E2A1;Q6P3T0;Q6ZWB8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005798 Golgi-associated vesicle;GO:0005874 microtubule;GO:0030424 axon;GO:0030425 dendrite;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0048813 dendrite morphogenesis;GO:0000226 microtubule cytoskeleton organization;GO:0050772 positive regulation of axonogenesis;GO:0032418 lysosome localization;GO:0030705 cytoskeleton-dependent intracellular transport",
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        "record_id": "Q96JE9-1",
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    },
    {
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        "uniprot_id": [
            {
                "id": "LYZL5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96QH8",
                "type": "external"
            }
        ],
        "mass": 17896.0,
        "length": 159,
        "protein_name": "Sperm acrosome-associated protein 5",
        "gene_name": "SPACA5B; SPACA5",
        "organism": "Human",
        "refseq_name": "sperm acrosome-associated protein 5 precursor",
        "refseq_ac": [
            {
                "id": "NP_001073369",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073369",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SPACA5B; SPACA5; LYZL5; PRO20753; SPACA5A",
        "gene_names_refseq": "LYZL5B; SPACA5B",
        "protein_names_uniprotkb": "Sperm acrosome-associated protein 5; 3.2.1.17; Lysozyme-like protein 5; SLLP-X; Sperm-specific lysozyme-like protein X",
        "protein_names_refseq": "SLLP-X; lysozyme-like protein 5; sperm acrosome-associated protein 5 precursor; sperm acrosome-associated protein 5; sperm-specific lysozyme-like protein X",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:389852);  (hsa:729201)",
        "pathway_count": 2,
        "publication_count": 2,
        "publication_id_list": "12975309;16382448",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "",
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        "secondary_ac_list": "Q6UWD1",
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        "go_molecular_function": "GO:0003796 lysozyme activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0001669 acrosomal vesicle;GO:0036126 sperm flagellum",
        "go_biological_process": "GO:0007342 fusion of sperm to egg plasma membrane involved in single fertilization",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q96QH8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.10100",
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    },
    {
        "uniprot_canonical_ac": "Q9HAY2-1",
        "uniprot_id": [
            {
                "id": "MAGF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HAY2",
                "type": "external"
            }
        ],
        "mass": 35222.0,
        "length": 307,
        "protein_name": "Melanoma-associated antigen F1",
        "gene_name": "MAGEF1",
        "organism": "Human",
        "refseq_name": "melanoma-associated antigen F1",
        "refseq_ac": [
            {
                "id": "NP_071432",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071432",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAGEF1",
        "gene_names_refseq": "MAGE-F1; MAGEF1",
        "protein_names_uniprotkb": "Melanoma-associated antigen F1; MAGE-F1 antigen; MAGE-F1",
        "protein_names_refseq": "MAGE-F1 antigen; melanoma antigen family F, 1; melanoma antigen family F1; melanoma-associated antigen F1",
        "tax_id": 9606,
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        "pathway": " (hsa:64110)",
        "pathway_count": 1,
        "publication_count": 80,
        "publication_id_list": "11313144;11454705;20800603;20864041;22645359;22869377;23475216;23481700;24029068;24714562;24715725;25418920;25469497;25576301;25645385;26024233;26728094;26992070;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28832583;28855257;28904123;29225034;29242379;29393594;29437277;29493099;29557506;29632046;29786170;29789417;30315122;30410026;30429286;30484775;30524438;30568303;30779550;30833945;31154438;31217245;31844290;31848261;31998317;32157095;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33479501;33537174;33592498;33633747;33936100;33968037;33981976;34185709;34211107;34290406;34357683;34405274;34509645;34932366;35051231;35580925;36010968;36241641;36284347",
        "class_list": "",
        "function": "Enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin ligases. Proposed to act through recruitment and/or stabilization of the E2 ubiquitin-conjugating enzyme at the E3:substrate complex. MAGEF1-NSMCE1 ubiquitin ligase complex promotes proteasomal degradation of MMS19, a key component of the cytosolic iron-sulfur protein assembly (CIA) machinery. Down-regulation of MMS19 impairs the activity of several DNA repair and metabolism enzymes such as ERCC2/XPD, FANCJ, RTEL1 and POLD1 that require iron-sulfur clusters as cofactors. May negatively regulate genome integrity by inhibiting homologous recombination-mediated double-strand break DNA repair (PubMed:29225034)., [UniProtKB, PubMed, PubMed]; MAGE-F1 specifies the cytosolic iron-sulfur assembly pathway protein MMS19 for ubiquitination and degradation., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This intronless gene encodes a member of the MAGE superfamily. It is ubiquitously expressed in normal tissues and in tumor cells. This gene includes a microsatellite repeat in the coding region. [provided by RefSeq, Jul 2008]., [RefSeq]",
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        "secondary_ac_list": "Q9H215",
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        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process",
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    },
    {
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                "id": "MAN1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y2U8",
                "type": "external"
            }
        ],
        "mass": 99997.0,
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        "protein_name": "Inner nuclear membrane protein Man1",
        "gene_name": "LEMD3",
        "organism": "Human",
        "refseq_name": "inner nuclear membrane protein Man1 isoform 2",
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            {
                "id": "NP_001161086",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161086",
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            }
        ],
        "gene_names_uniprotkb": "LEMD3; MAN1",
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        "protein_names_refseq": "LEM domain-containing protein 3; LEMD3/MKX fusion; MAN antigen 1; inner nuclear membrane protein Man1 isoform 2; inner nuclear membrane protein Man1; integral inner nuclear membrane protein",
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        "pathway": " (hsa:23592);  (R-HSA-2980766);  (R-HSA-2995383);  (R-HSA-4419969);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013405);  (R-HSA-9013408);  (R-HSA-9013423);  (R-HSA-9696264);  (R-HSA-9696270);  (R-HSA-9696273)",
        "pathway_count": 12,
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        "class_list": "",
        "function": "Analysis of the structural basis for R-SMAD recognition by MAN1 using SMAD2-MAN1 and SMAD1-MAN1 complex structures, [RefSeq, PubMed]; Can function as a specific repressor of TGF-beta, activin, and BMP signaling through its interaction with the R-SMAD proteins. Antagonizes TGF-beta-induced cell proliferation arrest., [UniProtKB, PubMed, PubMed]; Data describe the direct binding of the nuclear membrane protein MAN1 to emerin in vitro., [RefSeq, PubMed]; Melorheostosis and Osteopoikilosis Clinical and Molecular Description of an Italian Case Series., [RefSeq, PubMed]; Overexpression results in inhibition of R-Smad phosphorylation, heterodimerization with Smad4, and nuclear translocation, [RefSeq, PubMed]; The C-terminal domain of human MAN1 binds to Smad2 and Smad3 and antagonizes signaling by transforming growth factor-beta GeneRIF: Binds to Smad2 and Smad3 and antagonizes signaling by transforming growth factor-beta, [RefSeq, PubMed]; This locus encodes a LEM domain-containing protein. The encoded protein functions to antagonize transforming growth factor-beta signaling at the inner nuclear membrane. Two transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with osteopoikilosis, Buschke-Ollendorff syndrome and melorheostosis.[provided by RefSeq, Nov 2009]., [RefSeq]",
        "predicted_glycosites": 0,
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        "glycan_count": 7,
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        "secondary_ac_list": "Q9NT47;Q9NYA5",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990446 U1 snRNP binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0016020 membrane;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane",
        "go_biological_process": "GO:0030514 negative regulation of BMP signaling pathway;GO:0032926 negative regulation of activin receptor signaling pathway;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway",
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        "record_type": "protein",
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    },
    {
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        "uniprot_id": [
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                "id": "MDFI2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A1B0GVS7",
                "type": "external"
            }
        ],
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        "length": 189,
        "protein_name": "MyoD family inhibitor domain-containing protein 2",
        "gene_name": "MDFIC2",
        "organism": "Human",
        "refseq_name": "myoD family inhibitor domain-containing protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001351605",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001351605",
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            }
        ],
        "gene_names_uniprotkb": "MDFIC2",
        "gene_names_refseq": "MDFIC2",
        "protein_names_uniprotkb": "MyoD family inhibitor domain-containing protein 2",
        "protein_names_refseq": "myoD family inhibitor domain-containing protein 2 isoform 1; myoD family inhibitor domain-containing protein 2",
        "tax_id": 9606,
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        "pathway": " (hsa:107986096)",
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        "biomarker_type": "",
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        "secondary_ac_list": "A0A0U1T9V0;A0A0U1WUY1",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0045892 negative regulation of DNA-templated transcription;GO:0030111 regulation of Wnt signaling pathway;GO:0046328 regulation of JNK cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A0A1B0GVS7-1",
        "record_type": "protein",
        "filter_code": "0000000.0000001.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A1B0GVZ6-1",
        "uniprot_id": [
            {
                "id": "MB3LB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A1B0GVZ6",
                "type": "external"
            }
        ],
        "mass": 22665.0,
        "length": 204,
        "protein_name": "Methyl-CpG-binding domain protein 3-like 2B",
        "gene_name": "MBD3L2B",
        "organism": "Human",
        "refseq_name": "methyl-CpG-binding domain protein 3-like 2B",
        "refseq_ac": [
            {
                "id": "NP_001351603",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001351603",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MBD3L2B",
        "gene_names_refseq": "MBD3L2B",
        "protein_names_uniprotkb": "Methyl-CpG-binding domain protein 3-like 2B",
        "protein_names_refseq": "methyl-CpG-binding domain protein 3-like 2B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:729458)",
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        "class_list": "",
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        "go_molecular_function": "GO:0008327 methyl-CpG binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006346 DNA methylation-dependent constitutive heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A0A1B0GVZ6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000001.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A8MW99-1",
        "uniprot_id": [
            {
                "id": "MEI4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A8MW99",
                "type": "external"
            }
        ],
        "mass": 44024.0,
        "length": 385,
        "protein_name": "Meiosis-specific protein MEI4",
        "gene_name": "MEI4",
        "organism": "Human",
        "refseq_name": "meiosis-specific protein MEI4",
        "refseq_ac": [
            {
                "id": "NP_001269065",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269065",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MEI4",
        "gene_names_refseq": "MEI4",
        "protein_names_uniprotkb": "Meiosis-specific protein MEI4",
        "protein_names_refseq": "meiosis-specific 4 homolog; meiosis-specific protein MEI4-like; meiosis-specific protein MEI4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:101928601)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "10.1101/2023.09.13.557529;29393594;31704776;35051231;36215666;38252283",
        "class_list": "",
        "function": "Bi-allelic missense variants in MEI4 cause preimplantation embryonic arrest and female infertility., [RefSeq, PubMed]; Required for DNA double-strand breaks (DSBs) formation in unsynapsed regions during meiotic recombination. Probably acts by forming a complex with IHO1 and REC114, which activates DSBs formation in unsynapsed regions, an essential step to ensure completion of synapsis., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "R4GMV8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005694 chromosome;GO:0000800 lateral element",
        "go_biological_process": "GO:0006310 DNA recombination;GO:0007283 spermatogenesis;GO:0048477 oogenesis;GO:0007129 homologous chromosome pairing at meiosis;GO:0042138 meiotic DNA double-strand break formation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "A8MW99-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60337-4",
        "uniprot_id": [
            {
                "id": "MARH6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60337",
                "type": "external"
            }
        ],
        "mass": 102545.0,
        "length": 910,
        "protein_name": "E3 ubiquitin-protein ligase MARCHF6",
        "gene_name": "MARCHF6",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase MARCHF6 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001257589",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257589",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MARCHF6; KIAA0597; MARCH6; RNF176; TEB4",
        "gene_names_refseq": "DOA10; FAME3; FCMTE3; MARCH-VI; MARCH6; MARCHF6; RNF176; TEB4",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF6; 2.3.2.27; Doa10 homolog; MARCH-VI; Membrane-associated RING finger protein 6; Membrane-associated RING-CH protein VI; Protein TEB-4; RING finger protein 176; RING-type E3 ubiquitin transferase MARCHF6",
        "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH6; E3 ubiquitin-protein ligase MARCHF6 isoform 2; E3 ubiquitin-protein ligase MARCHF6; RING finger protein 176; RING-type E3 ubiquitin transferase MARCH6; RING-type E3 ubiquitin transferase MARCHF6; doa10 homolog; membrane associated ring finger 6; membrane-associated RING finger protein 6; membrane-associated RING-CH finger protein 6; membrane-associated RING-CH protein VI; membrane-associated ring finger (C3HC4) 6, E3 ubiquitin protein ligase",
        "tax_id": 9606,
        "disease": "familial adult myoclonic epilepsy 3 (Disease Ontology:DOID:0111695)",
        "pathway": " (hsa:10299);  (R-HSA-901032)",
        "pathway_count": 2,
        "publication_count": 112,
        "publication_id_list": "10409699;10694380;11641273;12913004;15673284;15713668;16373356;16431915;18003979;18264092;18417469;18426978;19084021;19651899;21872626;21993680;22424782;22645359;23232094;23481700;24449766;24714562;24715725;25088257;25092655;25418920;25469497;25576301;25645385;25892735;26024233;26154972;26375851;26728094;26992070;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29519897;29557506;29632046;29632711;29769354;29786170;30315122;30410026;30425097;30429286;30484775;30524438;30779550;31217245;31664039;31844290;31904814;32157095;32350084;32357974;32387766;32488085;32502341;32755570;32897882;32938616;32983136;33049405;33141586;33298915;33392160;33537174;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34273954;34357683;34405274;34509645;34512155;34932366;35051231;35318648;35561310;35580925;35941365;36010968;36215666;36241641;36284347;36958722;37938771;39216628",
        "class_list": "",
        "function": "Analysis of yeast endoplasmic reticulum-localized ubiquitin ligase Doa10 and comparison with its human ortholog TEB4, [RefSeq, PubMed]; Endoplasmic reticulum membrane-associated E3 ubiquitin ligase that plays a critical role in mitigating endoplasmic reticulum stress, the regulation of cholesterol and lipid homeostasis, and ferroptosis (PubMed:25088257, PubMed:35941365, PubMed:39216628). Acts as a pivotal component of both the Ac/N-degron pathway (targeting the N-terminal acetyl group of substrates) and the ER-associated protein degradation-cytosol (ERAD-C) pathway (targeting misfolded substrates) (PubMed:30425097, PubMed:35941365). For instance, mediates the degradation of Ac/N-degron-bearing proteins such as the G protein regulator RGS2 and the lipid droplet protein PLIN2 (PubMed:39216628). Suppresses endoplasmic reticulum stress and ferroptosis through cytosolic POMC degradation (By similarity). Prevents ferroptosis by acting as a NADPH sensor during lipid peroxidation through its C-terminal regulatory region (PubMed:35941365). Facilitates also the degradation of selected endoplasmic reticulum proteins by associating with signal peptide peptidase for the turnover of endogenous tail-anchored proteins (PubMed:29519897). Promotes ubiquitination of DIO2, leading to its degradation (PubMed:19651899). By ubiquitinating and thereby modulating the stability of many proteins of the cholesterol pathway including SQLE, CYP51A1, CYP11A1 and HMGCR, acts as a crucial post-translational regulator of cholesterol synthesis (PubMed:24449766, PubMed:31904814, PubMed:36958722)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; MARCH6 promotes Papillary Thyroid Cancer development by destabilizing DHX9. Publication Status: Online-Only, [RefSeq, PubMed]; MARCH6 promotes hepatocellular carcinoma development through up-regulation of ATF2. Publication Status: Online-Only, [RefSeq, PubMed]; The E3 ubiquitin ligase MARCHF6 as a metabolic integrator in cholesterol synthesis and beyond. Review article, [RefSeq, PubMed]; The MARCH6-SQLE Axis Controls Endothelial Cholesterol Homeostasis and Angiogenic Sprouting., [RefSeq, PubMed]; This gene encodes a member of a family of membrane-associated E3 ubiquitin ligases containing RING-CH-type zinc finger motifs. Ubiquitination of type II deiodinase by the encoded protein is an important regulatory step in thyroid hormone signalling. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Jul 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_mutagensis": 4,
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        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "glyco_site_count": 0,
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        "secondary_ac_list": "A5PKZ4;B4DKJ2;B4DT33;D3DTC8;O14670;Q86X77",
        "ec_number_list": [
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0061630 ubiquitin protein ligase activity;GO:0031624 ubiquitin conjugating enzyme binding;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044322 endoplasmic reticulum quality control compartment;GO:0000835 ER ubiquitin ligase complex",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0010498 proteasomal protein catabolic process;GO:0036503 ERAD pathway;GO:0070936 protein K48-linked ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "O60337-4",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95568-1",
        "uniprot_id": [
            {
                "id": "MET18_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95568",
                "type": "external"
            }
        ],
        "mass": 42148.0,
        "length": 372,
        "protein_name": "Histidine protein methyltransferase 1 homolog",
        "gene_name": "METTL18",
        "organism": "Human",
        "refseq_name": "histidine protein methyltransferase 1 homolog",
        "refseq_ac": [
            {
                "id": "NP_001307128",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307128",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL18; ASTP2; C1orf156",
        "gene_names_refseq": "AsTP2; C1orf156; HPM1; METTL18",
        "protein_names_uniprotkb": "Histidine protein methyltransferase 1 homolog; 2.1.1.85; Arsenic-transactivated protein 2; AsTP2; Methyltransferase-like protein 18",
        "protein_names_refseq": "arsenic-transactivated protein 2; histidine protein methyltransferase 1 homolog; methyltransferase 18, RPL3 N3-histidine; methyltransferase like 18; methyltransferase-like protein 18",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:92342)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "11237011;17525332;18669648;19064610;19536175;19615748;23186163;23349634;25576301;25880248;26154972;28832583;29242379;29557506;31844290;32157095;32161166;32357974;32488085;32938616;33693809;33968037;35051231;35580925;35674491;36010968;36241641",
        "class_list": "",
        "function": "Human METTL18 is a histidine-specific methyltransferase that targets RPL3 and affects ribosome biogenesis and function., [RefSeq, PubMed]; METTL18-mediated histidine methylation of RPL3 modulates translation elongation for proteostasis maintenance. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Protein-L-histidine N-tele-methyltransferase that specifically monomethylates RPL3, thereby regulating translation elongation (PubMed:23349634, PubMed:33693809, PubMed:35674491). Histidine methylation of RPL3 regulates translation elongation by slowing ribosome traversal on tyrosine codons: slower elongation provides enough time for proper folding of synthesized proteins and prevents cellular aggregation of tyrosine-rich proteins (PubMed:35674491)., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
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        "reported_phosphosites": 2,
        "reported_mutagensis": 4,
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        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R9T5",
        "ec_number_list": [
            {
                "id": "2.1.1.85",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.85",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0018064 protein-L-histidine N-tele-methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:2000232 regulation of rRNA processing;GO:0006417 regulation of translation;GO:0006448 regulation of translational elongation;GO:0018026 peptidyl-lysine monomethylation;GO:0090069 regulation of ribosome biogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "O95568-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P55001-1",
        "uniprot_id": [
            {
                "id": "MFAP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P55001",
                "type": "external"
            }
        ],
        "mass": 20826.0,
        "length": 183,
        "protein_name": "Microfibrillar-associated protein 2",
        "gene_name": "MFAP2",
        "organism": "Human",
        "refseq_name": "microfibrillar-associated protein 2 isoform b precursor",
        "refseq_ac": [
            {
                "id": "NP_001128719",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001128719",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MFAP2; MAGP1",
        "gene_names_refseq": "MAGP-1; MAGP1; MAGP; MFAP2",
        "protein_names_uniprotkb": "Microfibrillar-associated protein 2; MAGP-1; MAGP; MFAP-2; Microfibril-associated glycoprotein 1",
        "protein_names_refseq": "microfibril-associated glycoprotein 1; microfibrillar associated protein 2; microfibrillar-associated protein 2 isoform b precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4237);  (R-HSA-1566948);  (R-HSA-2129379)",
        "pathway_count": 3,
        "publication_count": 34,
        "publication_id_list": "10025398;10198291;10424889;10544250;10646116;10930463;10936461;11102756;11481325;11970960;12358597;12415008;12429738;1400330;14701737;16906757;1708799;17324935;18339631;21646718;27726376;30459171;33592498;33758160;34445187;35546486;36645203;37592847;6123066;7500359;7534784;7759096;8617364;9725916",
        "class_list": "",
        "function": "Component of the elastin-associated microfibrils., [UniProtKB]; Decreased Levels of Microfibril-Associated Glycoprotein (MAGP)-1 in Patients with Colon Cancer and Obesity Are Associated with Changes in Extracellular Matrix Remodelling. Publication Status: Online-Only, [RefSeq, PubMed]; Genome-Scale Analysis Identified NID2, SPARC, and MFAP2 as Prognosis Markers of Overall Survival in Gastric Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; MAGP1 maintains tumorigenicity and angiogenesis of laryngeal cancer by activating Wnt/beta-catenin/MMP7 pathway., [RefSeq, PubMed]; MFAP2 aggravates tumor progression through activating FOXM1/beta-catenin-mediated glycolysis in ovarian cancer., [RefSeq, PubMed]; MFAP2 promotes the progression of oral squamous cell carcinoma by activating the Wnt/beta-catenin signaling pathway through autophagy., [RefSeq, PubMed]; Microfibrillar-associated protein 2 is a major antigen of elastin-associated microfibrils and a candidate for involvement in the etiology of inherited connective tissue diseases. Four transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Sep 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
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        "missing_score": 3939,
        "biomarker_type": "",
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        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53X60;Q5JXY0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001968 fibronectin binding;GO:0070051 fibrinogen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:0001527 microfibril",
        "go_biological_process": "GO:0048048 embryonic eye morphogenesis;GO:0048050 post-embryonic eye morphogenesis;GO:0120162 positive regulation of cold-induced thermogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "P55001-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P55083-1",
        "uniprot_id": [
            {
                "id": "MFAP4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P55083",
                "type": "external"
            }
        ],
        "mass": 28648.0,
        "length": 255,
        "protein_name": "Microfibril-associated glycoprotein 4",
        "gene_name": "MFAP4",
        "organism": "Human",
        "refseq_name": "microfibril-associated glycoprotein 4 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001185624",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185624",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MFAP4",
        "gene_names_refseq": "MFAP4",
        "protein_names_uniprotkb": "Microfibril-associated glycoprotein 4",
        "protein_names_refseq": "microfibril-associated glycoprotein 4 isoform 1 precursor; microfibrillar associated protein 4",
        "tax_id": 9606,
        "disease": "Smith-Magenis syndrome (Disease Ontology:DOID:0060768)",
        "pathway": " (hsa:4239);  (R-HSA-2129379)",
        "pathway_count": 2,
        "publication_count": 44,
        "publication_id_list": "37268159;10.1101/2023.09.13.557529;10025398;10424889;10544250;10646116;10930463;11237011;11970960;12358597;12415008;12429738;1400330;14701737;15340161;16335952;1708799;17324935;18339631;19159218;21081667;21646718;24190977;24715725;26601954;27726376;29557506;29741879;31020640;31848261;32157095;33043033;34210950;35051231;35644509;36647950;37074911;37880056;38740766;40930100;7500359;7534784;7633408;9725916",
        "class_list": "",
        "function": "Could be involved in calcium-dependent cell adhesion or intercellular interactions. May contribute to the elastic fiber assembly and/or maintenance (PubMed:26601954)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Exploration of the Important Role of Microfibril-Associated Protein 4 Gene in Oral Squamous Cell Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Microfibril-associated glycoprotein 4 forms octamers that mediate interactions with elastogenic proteins and cells. Publication Status: Online-Only, [RefSeq, PubMed]; Microfibrillar-associated protein 4 in health and disease. Review article, [RefSeq, PubMed]; Presence of microfibril associated glycoprotein 4 and type V collagen and the possible absence of fibrillin-1 in bead-like structures in elastofibroma., [RefSeq, PubMed]; This gene encodes a protein with similarity to a bovine microfibril-associated protein. The protein has binding specificities for both collagen and carbohydrate. It is thought to be an extracellular matrix protein which is involved in cell adhesion or intercellular interactions. The gene is located within the Smith-Magenis syndrome region. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2010]., [RefSeq]; Tumor-suppressive role of microfibrillar associated protein 4 and its clinical significance as prognostic factor and diagnostic biomarker in hepatocellular carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "glycan_count": 119,
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        "secondary_ac_list": "A8KAJ1;A8MVM2;B4E317;Q6P680",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0001527 microfibril;GO:0071953 elastic fiber",
        "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0007155 cell adhesion;GO:0048251 elastic fiber assembly;GO:0097435 supramolecular fiber organization;GO:0009650 UV protection",
        "synthesized_glycan_count": 0,
        "hit_score": 16.8,
        "record_id": "P55083-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P59942-1",
        "uniprot_id": [
            {
                "id": "MCCD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P59942",
                "type": "external"
            }
        ],
        "mass": 13259.0,
        "length": 119,
        "protein_name": "Mitochondrial coiled-coil domain protein 1",
        "gene_name": "MCCD1",
        "organism": "Human",
        "refseq_name": "mitochondrial coiled-coil domain protein 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001011700",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001011700",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MCCD1",
        "gene_names_refseq": "MCCD1",
        "protein_names_uniprotkb": "Mitochondrial coiled-coil domain protein 1",
        "protein_names_refseq": "mitochondrial coiled-coil domain protein 1 precursor; mitochondrial coiled-coil domain protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:401250)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "14527716;19851445;20854863;29557506;30379171",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "A2AB29;A2RUP7;B0UZB2;Q7RTY2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "P59942-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16819-1",
        "uniprot_id": [
            {
                "id": "MEP1A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16819",
                "type": "external"
            }
        ],
        "mass": 84419.0,
        "length": 746,
        "protein_name": "Meprin A subunit alpha",
        "gene_name": "MEP1A",
        "organism": "Human",
        "refseq_name": "meprin A subunit alpha precursor",
        "refseq_ac": [
            {
                "id": "NP_005579",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005579",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MEP1A",
        "gene_names_refseq": "MEP1A; PPHA",
        "protein_names_uniprotkb": "Meprin A subunit alpha; 3.4.24.18; Endopeptidase-2; N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha; PABA peptide hydrolase; PPH alpha",
        "protein_names_refseq": "N-benzoyl-L-tyrosyl-P-amino-benzoic acid hydrolase subunit alpha; PPH alpha; bA268F1.1 (meprin A alpha (PABA peptide hydrolase)); endopeptidase-2; meprin A subunit alpha precursor; meprin A, alpha (PABA peptide hydrolase)",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283)",
        "pathway": " (hsa:4224)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;17976009;23481700;24388959;24474695;27378469;27399812;27999200;28502593;29557506;30444036;31154438;32488085;34932366;35051231;35494241;37074911;8262185",
        "class_list": "",
        "function": "In this review we report on recent findings that summarize the complex molecular regulation of meprins, particular folding, activation and shedding. Dysregulation of meprin alpha and meprin beta is often associated with pathological conditions such as neurodegeneration, inflammatory bowel disease and fibrosis Review article, [RefSeq, PubMed]; Mep1A is overexpressed in most hepatocellular carcinomas and induces tumor cell migration and invasion. Mep1A expression is regulated by Reptin, and Mep1A mediates Reptin-induced migration., [RefSeq, PubMed]; Meprin metalloproteases A and B inactivate interleukin 6, [RefSeq, PubMed]; Results showed that MEP1A expression was elevated in colorectal cancer (CRC) tissues at both the mRNA and protein levels, and provided evidence for its functionally crucial role in CRC carcinogenesis as tumor proliferation and invasion. Erratum:[BMC Cancer. 2018 Jan 11;18(1):70. doi: 10.1186/s12885-017-3767-6. PMID: 29325540] Publication Status: Online-Only, [RefSeq, PubMed]; Variants rs17468190 (G/T) in the MEP1A gene are associated with glucose and insulin metabolism in overweight/obese central European women with polycystic ovary syndrome., [RefSeq, PubMed]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 1,
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        "total_reported_n_glycosites": 4,
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        "secondary_ac_list": "A2RRM4;B0AZP9;B2RCS2;Q8TDC9;Q9H1R1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0070573 metallodipeptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0017090 meprin A complex",
        "go_biological_process": "GO:0038004 epidermal growth factor receptor ligand maturation;GO:0140448 signaling receptor ligand precursor processing;GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q16819-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5SR56-1",
        "uniprot_id": [
            {
                "id": "S71A2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5SR56",
                "type": "external"
            }
        ],
        "mass": 54545.0,
        "length": 506,
        "protein_name": "Solute carrier family 71 member 2",
        "gene_name": "SLC71A2",
        "organism": "Human",
        "refseq_name": "solute carrier family 71 member 2",
        "refseq_ac": [
            {
                "id": "NP_115947",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115947",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC71A2; HIATL1; MFSD14B",
        "gene_names_refseq": "HIATL1; MFSD14B; SLC71A2",
        "protein_names_uniprotkb": "Solute carrier family 71 member 2; Hippocampus abundant transcript-like protein 1; Major facilitator superfamily domain-containing 14B",
        "protein_names_refseq": "hippocampus abundant transcript-like 1; hippocampus abundant transcript-like protein 1; major facilitator superfamily domain containing 14B; solute carrier family 71 member 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84641)",
        "pathway_count": 1,
        "publication_count": 47,
        "publication_id_list": "23481700;25502872;25576301;25645385;26154972;26811146;26992070;27600516;27723779;27846572;28228285;28467828;28832583;29242379;29314611;29393594;29437277;29508533;29557506;30315122;30429286;30484775;30779550;31844290;32157095;32350084;32387766;32488085;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33691108;33912179;33936100;33968037;34087483;34357683;35051231;35154160;35494241;36215666;36241641;37938771",
        "class_list": "",
        "function": "Probable membrane-bound transporter. May play a role in neuronal nutrient sensing and energy homeostasis., [UniProtKB, UniProtKB]; We identified interaction between CRC risk and alcohol consumption and variants in the 9q22.32/HIATL1 region. Compared to non-/occasional drinking light to moderate alcohol consumption was associated with a lower risk of colorectal cancer among individuals with rs9409565 CT genotype and TT genotypes Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
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        "missing_score": 10000,
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        "secondary_ac_list": "B4DUE6;E9PD58;Q3KQT4;Q53GU5;Q8WU95;Q96SM4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
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        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q68D91-1",
        "uniprot_id": [
            {
                "id": "MBLC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q68D91",
                "type": "external"
            }
        ],
        "mass": 31372.0,
        "length": 279,
        "protein_name": "Acyl-coenzyme A thioesterase MBLAC2",
        "gene_name": "MBLAC2",
        "organism": "Human",
        "refseq_name": "acyl-coenzyme A thioesterase MBLAC2",
        "refseq_ac": [
            {
                "id": "NP_981951",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_981951",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MBLAC2",
        "gene_names_refseq": "MBLAC2",
        "protein_names_uniprotkb": "Acyl-coenzyme A thioesterase MBLAC2; 3.1.2.2; 3.5.2.6; Acyl-CoA thioesterase MBLAC2; Beta-lactamase MBLAC2; Metallo-beta-lactamase domain-containing protein 2; Palmitoyl-coenzyme A thioesterase MBLAC2",
        "protein_names_refseq": "acyl-CoA thioesterase MBLAC2; acyl-coenzyme A thioesterase MBLAC2; beta-lactamase MBLAC2; metallo-beta-lactamase domain-containing protein 2; palmitoyl-coenzyme A thioesterase MBLAC2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:153364)",
        "pathway_count": 1,
        "publication_count": 38,
        "publication_id_list": "25502872;25880248;26154972;26992070;28228285;28832583;28904123;29242379;29557506;29632711;30410026;30573663;31154438;31217245;31434986;31844290;32157095;32350084;32357974;32387766;32488085;32938616;33219126;33392160;33537174;33592498;33912179;33968037;34185709;34357683;34509645;35051231;35154160;35251023;35580925;36010968;36215666;37938771",
        "class_list": "",
        "function": "Acyl-CoA thioesterases are a group of enzymes that catalyze the hydrolysis of acyl-CoAs to the free fatty acid and coenzyme A (CoASH), providing the potential to regulate intracellular levels of acyl-CoAs, free fatty acids and CoASH (PubMed:33219126). Has an acyl-CoA thioesterase activity towards the long chain fatty acyl-CoA thioester palmitoyl-CoA (hexadecanoyl-CoA; C16:0-CoA) (PubMed:33219126). Displays a substrate preference for fatty acyl-CoAs with chain-lengths C12-C18 (PubMed:33219126). Possesses beta-lactamase activity, catalyzing the hydrolysis of penicillin G and nitrocefin (PubMed:31434986). Exhibits no activity towards other beta-lactam antibiotic classes including cephalosporins (cefotaxime) and carbapenems (imipenem) (PubMed:31434986)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "predicted_c_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "D6RJI1;Q8IY16;Q8N8D8",
        "ec_number_list": [
            {
                "id": "3.1.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.2",
                "type": "external"
            },
            {
                "id": "3.1.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.27",
                "type": "external"
            },
            {
                "id": "3.1.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.1",
                "type": "external"
            },
            {
                "id": "3.1.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.11",
                "type": "external"
            },
            {
                "id": "3.1.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.3",
                "type": "external"
            },
            {
                "id": "3.1.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.5",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.5",
                "type": "external"
            },
            {
                "id": "3.4.13.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.13.19",
                "type": "external"
            },
            {
                "id": "3.5.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6",
                "type": "external"
            },
            {
                "id": "3.1.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.-",
                "type": "external"
            },
            {
                "id": "2.3.1.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16",
                "type": "external"
            },
            {
                "id": "2.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9",
                "type": "external"
            },
            {
                "id": "3.1.2.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.22",
                "type": "external"
            },
            {
                "id": "2.3.1.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.65",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.1.2.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0052816 long-chain fatty acyl-CoA hydrolase activity;GO:0008800 beta-lactamase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006631 fatty acid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "Q68D91-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y6G1-1",
        "uniprot_id": [
            {
                "id": "TM14A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y6G1",
                "type": "external"
            }
        ],
        "mass": 10712.0,
        "length": 99,
        "protein_name": "Transmembrane protein 14A",
        "gene_name": "TMEM14A",
        "organism": "Human",
        "refseq_name": "transmembrane protein 14A",
        "refseq_ac": [
            {
                "id": "NP_054770",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_054770",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TMEM14A; C6orf73; PTD011",
        "gene_names_refseq": "C6orf73; PTD011; TMEM14A",
        "protein_names_uniprotkb": "Transmembrane protein 14A",
        "protein_names_refseq": "transmembrane protein 14A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:28978)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "18991276;21723035;22609626;26811146;26896463;26992070;28834231;29557506;29632711;29769354;30429286;30853176;31844290;32265295;33592498;33968037;36010968;37839105;39894887",
        "class_list": "",
        "function": "AXL transcriptionally up-regulates TMEM14A expression to mediate cell proliferation in non-small-cell lung cancer cells., [RefSeq, PubMed]; Findings show for the first time that TMEM14A inhibits apoptosis by blocking the mitochondrial permeability transition and stabilizing mitochondrial membrane potential, [RefSeq, PubMed]; Inhibits apoptosis via negative regulation of the mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway., [UniProtKB, PubMed]; MiR-1179 is sponged by circular RNA circ_0003645 and TMEM14A is a target of miR-1179., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
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        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R552",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0031966 mitochondrial membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0006915 apoptotic process;GO:1901029 negative regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q9Y6G1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NC44-1",
        "uniprot_id": [
            {
                "id": "RETR2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NC44",
                "type": "external"
            }
        ],
        "mass": 57830.0,
        "length": 543,
        "protein_name": "Reticulophagy regulator 2",
        "gene_name": "RETREG2",
        "organism": "Human",
        "refseq_name": "reticulophagy regulator 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_077269",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077269",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RETREG2; C2orf17; FAM134A; MAG2",
        "gene_names_refseq": "C2orf17; FAM134A; MAG-2; RETREG2",
        "protein_names_uniprotkb": "Reticulophagy regulator 2",
        "protein_names_refseq": "family with sequence similarity 134 member A; metastasis associated gene-2; protein FAM134A; reticulophagy regulator 2 isoform 1; reticulophagy regulator 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79137)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "11230166;11237011;17081983;17322306;18088087;18318008;18452278;18578522;18669648;18767875;19007248;19212629;19415658;19651622;19690332;20068231;21406692;23186163;24275569;25892735;26040720;28218747;28832583;28904123;29097687;29242379;29557506;29769354;30315122;30429286;31217245;31611695;31844290;31848261;32157095;32350084;32387766;32488085;33392160;33592498;33968037;34171305;34338405;34561969;34854256;35051231;35251023;35580925;36010968",
        "class_list": "",
        "function": "Depleting the endoplasmic reticulum-localized protein FAM134A impairs mitotic progression by affecting metaphase plate alignment and pressure generation by delocalizing cortical myosin II. Publication Status: Online-Only, [RefSeq, PubMed]; Endoplasmic reticulum (ER)-anchored autophagy regulator which exists in an inactive state under basal conditions but is activated following cellular stress (PubMed:34338405). When activated, induces ER fragmentation and mediates ER delivery into lysosomes through sequestration into autophagosomes via interaction with ATG8 family proteins (PubMed:34338405). Required for collagen quality control in a LIR motif-independent manner (By similarity)., [UniProtKB, UniProtKB, PubMed]; MAG-2 may be a novel causal gene for lung cancer invasion and metastasis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 13,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6P1P5;Q9H0K7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0140506 endoplasmic reticulum-autophagosome adaptor activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q8NC44-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H1A3-1",
        "uniprot_id": [
            {
                "id": "METL9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H1A3",
                "type": "external"
            }
        ],
        "mass": 36536.0,
        "length": 318,
        "protein_name": "Protein-L-histidine N-pros-methyltransferase",
        "gene_name": "METTL9",
        "organism": "Human",
        "refseq_name": "protein-L-histidine N-pros-methyltransferase isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001070648",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001070648",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL9; CGI-81; DREV",
        "gene_names_refseq": "CGI-81; DREV1; DREV; METTL9; PAP1; hMETTL9",
        "protein_names_uniprotkb": "Protein-L-histidine N-pros-methyltransferase; 2.1.1.-; DORA reverse strand protein; DREV1; DREV; Methyltransferase-like protein 9; hMETTL9",
        "protein_names_refseq": "CTB-31N19.3; DORA reverse strand protein 1; methyltransferase 9, His-X-His N1-histidine; methyltransferase like 9; methyltransferase-like protein 9; p53 activated protein 1; protein-L-histidine N-pros-methyltransferase isoform 2 precursor; protein-L-histidine N-pros-methyltransferase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51108)",
        "pathway_count": 1,
        "publication_count": 62,
        "publication_id_list": "10.1101/2023.09.13.557529;11132146;11237011;16837177;17081983;23481700;24190977;24715725;25576301;26992070;27600516;27846572;28228285;28514659;28649982;28834231;28904123;29242379;29331515;29393594;29557506;30315122;30524438;31020640;31092671;31154438;31844290;31848261;31937595;32157095;32161166;32350084;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33563959;33691108;33912179;33936100;33968037;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34562450;35051231;35494241;35580925;36215666;36241641;37015930;37074911;37158456;37398635;37938771",
        "class_list": "",
        "function": "Cloned the PAP1 gene, a p53 activated protein, from a U251-pTet-p53 cell line which carried a wild-type p53 transgene., [RefSeq, PubMed]; METTL9 derived circular RNA circ-METTL9 sponges miR-551b-5p to accelerate colorectal cancer progression by upregulating CDK6., [RefSeq, PubMed]; Protein-histidine N-methyltransferase that specifically catalyzes 1-methylhistidine (pros-methylhistidine) methylation of target proteins (PubMed:33563959, PubMed:34562450, PubMed:37015930, PubMed:37398635). Specifically methylates the second His of proteins with a His-x-His (HxH) motif (where 'x' is preferably a small amino acid), while exploiting the first one as a recognition signature (PubMed:37398635). Catalyzes methylation of target proteins such as S100A9, NDUFB3, SLC39A5, SLC39A7, ARMC6 and DNAJB12; 1-methylhistidine modification may affect the binding of zinc and other metals to its target proteins (PubMed:33563959, PubMed:34562450, PubMed:37015930, PubMed:37398635). Constitutes the main methyltransferase for the 1-methylhistidine modification in cell (PubMed:33563959)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; SiRNA screening identifies METTL9 as a histidine Npi-methyltransferase that targets the proinflammatory protein S100A9., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 18,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 9641,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NBT8;Q9BWJ7;Q9H1A2;Q9Y390",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "2.1.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.22",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0106370 protein-L-histidine N-pros-methyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum",
        "go_biological_process": "GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q9H1A3-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1000000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WXI7-1",
        "uniprot_id": [
            {
                "id": "MUC16_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WXI7",
                "type": "external"
            }
        ],
        "mass": 1519175.0,
        "length": 14507,
        "protein_name": "Mucin-16",
        "gene_name": "MUC16",
        "organism": "Human",
        "refseq_name": "mucin-16 isoform 4",
        "refseq_ac": [
            {
                "id": "NP_078966",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078966",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MUC16; CA125",
        "gene_names_refseq": "CA125; MUC16",
        "protein_names_uniprotkb": "Mucin-16; CA-125; MUC-16; Ovarian cancer-related tumor marker CA125; Ovarian carcinoma antigen CA125",
        "protein_names_refseq": "CA125 ovarian cancer antigen; cancer antigen 125; mucin-16 isoform 4; mucin-16; ovarian cancer-related tumor marker CA125; ovarian carcinoma antigen CA125",
        "tax_id": 9606,
        "disease": "dry eye syndrome (Disease Ontology:DOID:10140); Sjogren's syndrome (Disease Ontology:DOID:12894); pancreatic cancer (Disease Ontology:DOID:1793); ovarian cancer (Disease Ontology:DOID:2394); ovarian carcinoma (Disease Ontology:DOID:4001); cholangiocarcinoma (Disease Ontology:DOID:4947); keratoconjunctivitis (Disease Ontology:DOID:9368)",
        "pathway": " (hsa:94025);  (R-HSA-5083625);  (R-HSA-5083632);  (R-HSA-5083636);  (R-HSA-5621480);  (R-HSA-913709);  (R-HSA-977068)",
        "pathway_count": 7,
        "publication_count": 122,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10330415;10430883;10504389;10742600;10753916;11042166;11062056;11110698;11237011;11283017;11304796;11369781;11606584;11786729;11821425;12218296;12464682;12734200;12855678;1329093;14656219;14676194;15466199;15486459;15560372;15599692;15620693;15687324;15788735;16151858;16251947;16319059;16384952;17050534;17081983;17113861;18452278;18490740;18491316;18537974;18776906;18818202;19617566;20068231;20112406;20934997;21683503;21880719;22041900;22183981;22461326;23053572;23507963;23584533;23602766;2373995;24190977;24643043;24674678;24715725;25153226;26374642;26992070;28121444;28411811;28904123;29093164;29351928;29557506;29786170;29958235;30429286;30484775;31217245;31324691;31844290;32157095;32347972;32357974;32387766;32488085;32938616;32983136;33091337;33912179;33936100;33968037;34087483;34171305;34509645;34561969;34696226;34932366;35289036;35494241;35580925;36215666;36241641;36284347;37074911;37217939;38253038;38285795;38920720;39024979;39240165;7655172;8333853;8598452;8611500;8920913;8972730;9042338;9276028;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "",
        "function": "Gender and melanoma subtype-based prognostic implications of MUC16 and TTN co-occurrent mutations in melanoma: A retrospective multi-study analysis., [RefSeq, PubMed]; Human Epididymis Protein 4 (HE4) and Cancer Antigen 125 (CA125) for Prediction of Optimal Primary Surgery in Non-Mucinous Epithelial Ovarian Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Ovarian carcinoma antigen CA125 may induce specific immunomodulatory effects by employing its carbohydrate sequences as functional groups, thereby promoting tumor progression, [RefSeq, PubMed]; TRPV4 activation in human corneal epithelial cells promotes membrane mucin production., [RefSeq, PubMed]; The CA 125 gene: a newly discovered extension of the glycosylated N-terminal domain doubles the size of this extracellular superstructure, [RefSeq, PubMed]; This gene encodes a protein that is a member of the mucin family. Mucins are high molecular weight, O-glycosylated proteins that play an important role in forming a protective mucous barrier, and are found on the apical surfaces of the epithelia. The encoded protein is a membrane-tethered mucin that contains an extracellular domain at its amino terminus, a large tandem repeat domain, and a transmembrane domain with a short cytoplasmic domain. The amino terminus is highly glycosylated, while the repeat region contains 156 amino acid repeats unit that are rich in serines, threonines, and prolines. Interspersed within the repeats are Sea urchin sperm protein Enterokinase and Agrin (SEA) modules, leucine-rich repeats and ankyrin (ANK) repeats. These regions together form the ectodomain, and there is a potential cleavage site found near an SEA module close to the transmembrane domain. This protein is thought to play a role in forming a barrier, protecting epithelial cells from pathogens. Products of this gene have been used as a marker for different cancers, with higher expression levels associated with poorer outcomes. [provided by RefSeq, May 2017]., [RefSeq]; Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces., [UniProtKB]",
        "predicted_glycosites": 116,
        "predicted_n_glycosites": 70,
        "predicted_o_glycosites": 46,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 32,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 33,
        "reported_o_glycosites_with_glycan": 131,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 33,
        "total_reported_o_glycosites": 131,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 33,
        "total_o_glycosites": 131,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1318,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "predictive; monitoring; prognostic",
        "glycan_count": 23,
        "disease_count": 7,
        "glyco_site_count": 280,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5ME49;Q6ZQW5;Q96RK2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane;GO:0031982 vesicle",
        "go_biological_process": "GO:0007155 cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 31.0,
        "record_id": "Q8WXI7-1",
        "record_type": "protein",
        "filter_code": "0111000.1000111.000010.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NRN9-1",
        "uniprot_id": [
            {
                "id": "METL5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NRN9",
                "type": "external"
            }
        ],
        "mass": 23719.0,
        "length": 209,
        "protein_name": "rRNA N(6)-adenosine-methyltransferase METTL5",
        "gene_name": "METTL5",
        "organism": "Human",
        "refseq_name": "rRNA N(6)-adenosine-methyltransferase METTL5",
        "refseq_ac": [
            {
                "id": "NP_001280115",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280115",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL5; DC3; HSPC133",
        "gene_names_refseq": "HSPC133; METTL5; MRT72",
        "protein_names_uniprotkb": "rRNA N(6)-adenosine-methyltransferase METTL5; 2.1.1.-; Methyltransferase-like protein 5",
        "protein_names_refseq": "methyltransferase like 5; methyltransferase-like protein 5; rRNA N(6)-adenosine-methyltransferase METTL5; rRNA N6-adenosine-methyltransferase METTL5",
        "tax_id": 9606,
        "disease": "autosomal recessive intellectual developmental disorder 72 (Disease Ontology:DOID:0080765)",
        "pathway": " (hsa:29081)",
        "pathway_count": 1,
        "publication_count": 61,
        "publication_id_list": "11237011;23481700;24366607;24397554;24714562;25418920;25505266;26154972;26375851;26728094;26929215;26992070;27846572;27920218;28063628;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29786170;30315122;30429286;31328227;31530632;31564433;31844290;31848261;32157095;32161166;32217665;32357974;32387766;32488085;32502341;32938616;32983136;33298915;33357433;33428944;33691108;33717175;33912179;33968037;34932366;34948388;35033535;35051231;35580925;36602428;38613157;38663914;39023781;39182664",
        "class_list": "",
        "function": "Biological significance of METTL5 in atherosclerosis: comprehensive analysis of single-cell and bulk RNA sequencing data., [RefSeq, PubMed]; Catalytic subunit of a heterodimer with TRMT112, which specifically methylates the 6th position of adenine in position 1832 of 18S rRNA (PubMed:31328227, PubMed:32217665, PubMed:33357433, PubMed:33428944, PubMed:35033535). N6-methylation of adenine(1832) in 18S rRNA resides in the decoding center of 18S rRNA and is required for translation and embryonic stem cells (ESCs) pluripotency and differentiation (PubMed:33357433)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; METTL5 enhances the mRNA stability of TPRKB through m[6]A modification to facilitate the aggressive phenotypes of hepatocellular carcinoma cell., [RefSeq, PubMed]; METTL5 stabilizes c-Myc by facilitating USP5 translation to reprogram glucose metabolism and promote hepatocellular carcinoma progression., [RefSeq, PubMed]; METTL5-TRMT112 partners act by extruding the adenosine to be modified from a double-stranded nucleic acid., [RefSeq, PubMed]; METTL5: A Potential Biomarker for Nonsmall Cell Lung Cancer That Promotes Cancer Cell Proliferation by Interacting with IGF2BP3., [RefSeq, PubMed]; The m6A methyltransferase METTL5 promotes neutrophil extracellular trap network release to regulate hepatocellular carcinoma progression., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DPC9;Q9NVX1",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003676 nucleic acid binding;GO:1904047 S-adenosyl-L-methionine binding;GO:0008988 rRNA (adenine-N6-)-methyltransferase activity;GO:0016740 transferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0001650 fibrillar center;GO:0098794 postsynapse",
        "go_biological_process": "GO:0031167 rRNA methylation;GO:0048863 stem cell differentiation;GO:0045727 positive regulation of translation;GO:0006364 rRNA processing;GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q9NRN9-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZSS7-1",
        "uniprot_id": [
            {
                "id": "MFSD6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZSS7",
                "type": "external"
            }
        ],
        "mass": 88088.0,
        "length": 791,
        "protein_name": "Major facilitator superfamily domain-containing protein 6",
        "gene_name": "MFSD6",
        "organism": "Human",
        "refseq_name": "major facilitator superfamily domain-containing protein 6 isoform a",
        "refseq_ac": [
            {
                "id": "NP_060164",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060164",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MFSD6; MMR2",
        "gene_names_refseq": "MFSD6; MMR2; SLC73A1; hMMR2",
        "protein_names_uniprotkb": "Major facilitator superfamily domain-containing protein 6; Macrophage MHC class I receptor 2 homolog",
        "protein_names_refseq": "macrophage MHC class I receptor 2 homolog; macrophage MHC receptor 2; major facilitator superfamily domain-containing protein 6 isoform a; major facilitator superfamily domain-containing protein 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54842)",
        "pathway_count": 1,
        "publication_count": 39,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;18578522;19401682;19651622;20123006;20978832;23186163;23481700;24366607;25418920;25502872;25880248;28228285;28514659;28832583;28904123;29242379;29741879;29769354;31092671;31154438;31217245;31844290;32157095;32350084;32502341;32938616;32983136;33392160;33912179;33936100;33968037;34171305;34357683;35051231;35251023;39798568;40132641",
        "class_list": "",
        "function": "(Microbial infection) Acts as a receptor for respiratory enterovirus D68 (PubMed:39798568, PubMed:40132641). Mechanistically, binds to viral particles and is required for viral cell entry while initial attachment to cells is mainly mediated by interactions with sialic acid (PubMed:40132641)., [UniProtKB, PubMed, PubMed]; Observational study of gene-disease association, gene-gene interaction, and gene-environment interaction. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3KSZ4;Q86TH2;Q9NXM3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q6ZSS7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZRQ5-1",
        "uniprot_id": [
            {
                "id": "MMS22_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZRQ5",
                "type": "external"
            }
        ],
        "mass": 142321.0,
        "length": 1243,
        "protein_name": "Protein MMS22-like",
        "gene_name": "MMS22L",
        "organism": "Human",
        "refseq_name": "protein MMS22-like isoform a",
        "refseq_ac": [
            {
                "id": "NP_940870",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940870",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MMS22L; C6orf167",
        "gene_names_refseq": "C6orf167; MMS22L; dJ39B17.2",
        "protein_names_uniprotkb": "Protein MMS22-like; Methyl methanesulfonate-sensitivity protein 22-like",
        "protein_names_refseq": "protein MMS22-like isoform a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:253714)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "11237011;21055983;21055984;21055985;21113133;23481700;24715725;25576301;25880248;26527279;26992070;27338793;27797818;27846572;28218747;28904123;29437277;29478807;29493099;29557506;30410026;31217245;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33392160;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34509645;35051231;35580925;36010968;36241641;36581221;36622344;39894887",
        "class_list": "",
        "function": "Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:21113133, PubMed:26527279, PubMed:27338793, PubMed:29478807). The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:27797818). It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:29478807). Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination (PubMed:27797818, PubMed:29478807). Within the complex, MMS22L acts by binding ssDNA (PubMed:27797818)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; MMS22L and TONSL are required for the maintenance of genome stability., [RefSeq, PubMed]; MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC. Publication Status: Online-Only, [RefSeq, PubMed]; Results strongly suggest that the Mms22L-Nfkbil2 complex contributes to genome stability by regulating the chromatin state at stalled replication forks., [RefSeq, PubMed]; The protein encoded by this gene forms a complex with tonsoku-like, DNA repair protein (TONSL), and this complex recognizes and repairs DNA double-strand breaks at sites of stalled or collapsed replication forks. The encoded protein also can bind with the histone-associated protein NFKBIL2 to help regulate the chromatin state at stalled replication forks. Finally, this gene appears to be overexpressed in most lung and esophageal cancers. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2017]., [RefSeq]; These results indicate that MMS22L and TONSL are genome caretakers that stimulate the recombination-dependent repair of stalled or collapsed replication forks., [RefSeq, PubMed]; This study identifies MMS22L-NFKBIL2 as components of the replication stress control pathway., [RefSeq, PubMed]; Uncovered DNA-PKcs-dependent DNA damage-induced ASF1A phosphorylation, which enhances chromatin assembly, promoting MMS22L-TONSL recruitment and, hence, Rad51 loading. Erratum:[Mol Cell. 2020 Mar 5;77(5):1153. doi: 10.1016/j.molcel.2020.02.019. PMID: 32142686], [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6R9Y8;D6RBQ4;E1P529;Q5THT2;Q68CQ6;Q68D32",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003697 single-stranded DNA binding",
        "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0035861 site of double-strand break;GO:0090734 site of DNA damage",
        "go_biological_process": "GO:0006325 chromatin organization;GO:0000724 double-strand break repair via homologous recombination;GO:0031297 replication fork processing;GO:0071168 protein localization to chromatin",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q6ZRQ5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BUU2-1",
        "uniprot_id": [
            {
                "id": "MET22_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BUU2",
                "type": "external"
            }
        ],
        "mass": 44486.0,
        "length": 404,
        "protein_name": "Methyltransferase-like protein 22",
        "gene_name": "METTL22",
        "organism": "Human",
        "refseq_name": "methyltransferase-like protein 22",
        "refseq_ac": [
            {
                "id": "NP_077014",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077014",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL22; C16orf68; LP8272",
        "gene_names_refseq": "C16orf68; METTL22",
        "protein_names_uniprotkb": "Methyltransferase-like protein 22; 2.1.1.-",
        "protein_names_refseq": "LP8272; methyltransferase like 22; methyltransferase-like protein 22",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79091);  (R-HSA-8876725)",
        "pathway_count": 2,
        "publication_count": 27,
        "publication_id_list": "11237011;15498874;16118227;23186163;23349634;24275569;25144183;25231979;25416781;25880248;25892735;26545399;28218747;28904123;29393594;29437277;29557506;29632711;29769354;31844290;32157095;32357974;33298915;33912179;34087483;35580925;36241641",
        "class_list": "",
        "function": "METTL22 trimethylates Lys-135 in Kin17, [RefSeq, PubMed]; Protein N-lysine methyltransferase. Trimethylates KIN at Lys-135 (in vitro)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RD29;D3DUF2;Q6XYB4;Q9HA03",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "2.1.1.359",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359",
                "type": "external"
            },
            {
                "id": "2.1.1.372",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0008276 protein methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0006479 protein methylation;GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q9BUU2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16653-1",
        "uniprot_id": [
            {
                "id": "MOG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16653",
                "type": "external"
            }
        ],
        "mass": 28193.0,
        "length": 247,
        "protein_name": "Myelin-oligodendrocyte glycoprotein",
        "gene_name": "MOG",
        "organism": "Human",
        "refseq_name": "myelin-oligodendrocyte glycoprotein isoform alpha3 precursor",
        "refseq_ac": [
            {
                "id": "NP_001008229",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008229",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MOG",
        "gene_names_refseq": "BTN6; BTNL11; MOGIG2; MOG; NRCLP7",
        "protein_names_uniprotkb": "Myelin-oligodendrocyte glycoprotein",
        "protein_names_refseq": "MOG AluA; MOG AluB; MOG Ig-AluB; MOG alpha-5; myelin-oligodendrocyte glycoprotein isoform alpha3 precursor",
        "tax_id": 9606,
        "disease": "optic neuritis (Disease Ontology:DOID:1210); multiple sclerosis (Disease Ontology:DOID:2377); neuromyelitis optica (Disease Ontology:DOID:8869); narcolepsy (Disease Ontology:DOID:8986)",
        "pathway": " (hsa:4340)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;12023398;12077287;16903876;17402967;17573820;17911594;21880773;21907016;21928277;32625206;35051231;38576611;7790876;7964757;8530032;8666381;8915905;9210466",
        "class_list": "",
        "function": "(Microbial infection) Acts as a receptor for rubella virus., [UniProtKB, PubMed]; Differentiated pattern of complement system activation between MOG-IgG-associated disease and AQP4-IgG-positive neuromyelitis optica spectrum disorder. Publication Status: Online-Only, [RefSeq, PubMed]; In human brain the splice variants of MOG appear at a late stage compared to the major isoform, coincidental with myelination and myelin maturation, unlike other myelin proteins., [RefSeq, PubMed]; Mediates homophilic cell-cell adhesion (By similarity). Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication., [UniProtKB]; Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Our findings highlight myelin oligodendrocyte glycoprotein splicing as a factor that could be critical to the phenotypic expression of multiple sclerosis., [RefSeq, PubMed]; The product of this gene is a membrane protein expressed on the oligodendrocyte cell surface and the outermost surface of myelin sheaths. Due to this localization, it is a primary target antigen involved in immune-mediated demyelination. This protein may be involved in completion and maintenance of the myelin sheath and in cell-cell communication. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]; This study represents the first evidence of alternative translation products from the MOG gene. To date, it is believed that alternative splicing of MOG is limited to primates., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
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        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
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        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NDR4;A6NNJ9;A8MY31;B0UZR9;E9PGF0;F8W9D5;O00713;O00714;O00715;Q13054;Q13055;Q14855;Q29ZN8;Q56UY0;Q5JNX7;Q5JNY1;Q5JNY2;Q5JNY4;Q5SSB5;Q5SSB6;Q5STL9;Q5STM0;Q5STM1;Q5STM2;Q5STM5;Q5SUK5;Q5SUK7;Q5SUK8;Q5SUK9;Q5SUL0;Q5SUL1;Q8IYG5;Q92891;Q92892;Q92893;Q92894;Q92895;Q93053;Q96KU9;Q96KV0;Q96KV1;Q99605",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0001618 virus receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0050852 T cell receptor signaling pathway;GO:0007417 central nervous system development;GO:0001817 regulation of cytokine production",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q16653-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9GZY8-1",
        "uniprot_id": [
            {
                "id": "MFF_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9GZY8",
                "type": "external"
            }
        ],
        "mass": 38465.0,
        "length": 342,
        "protein_name": "Mitochondrial fission factor",
        "gene_name": "MFF",
        "organism": "Human",
        "refseq_name": "mitochondrial fission factor isoform f",
        "refseq_ac": [
            {
                "id": "NP_001263996",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263996",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MFF; AD030; AD033; C2orf33; GL004",
        "gene_names_refseq": "C2orf33; EMPF2; GL004; MFF",
        "protein_names_uniprotkb": "Mitochondrial fission factor",
        "protein_names_refseq": "mitochondrial fission factor isoform f",
        "tax_id": 9606,
        "disease": "encephalopathy due to defective mitochondrial and peroxisomal fission 2 (Disease Ontology:DOID:0060994); transient cerebral ischemia (Disease Ontology:DOID:224)",
        "pathway": " (hsa:56947)",
        "pathway_count": 1,
        "publication_count": 64,
        "publication_id_list": "11237011;16959974;17081983;18212344;18220336;18353969;18669648;19651622;20068231;21406692;21509594;22869377;23186163;23481700;23530241;23783831;23921378;24196833;24715725;26783368;26816379;26992070;27600516;27726376;27846572;27920218;28063628;28467828;28832583;28904123;29242379;29314611;29317506;29493099;29557506;29725013;30059200;30379171;30429286;31112535;31217245;31492838;31844290;31848261;32157095;32350084;32387766;33298915;33592498;33912179;33936100;33968037;34357683;34460078;34561969;34750646;35051231;35154160;35251023;35561310;35580925;36010968;36241641;40596516",
        "class_list": "",
        "function": "Hypoxia-induced ROS promotes mitochondrial fission and cisplatin chemosensitivity via HIF-1alpha/Mff regulation in head and neck squamous cell carcinoma., [RefSeq, PubMed]; MFF gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma., [RefSeq, PubMed]; Mff is a novel component of a conserved membrane fission pathway used for constitutive and induced fission of mitochondria and peroxisomes., [RefSeq, PubMed]; Mitochondrial ''dysmorphology'' in variant classification., [RefSeq, PubMed]; Plays a role in mitochondrial and peroxisomal fission (PubMed:18353969, PubMed:23530241, PubMed:24196833). Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface (PubMed:23530241). May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This is a nuclear gene encoding a protein that functions in mitochondrial and peroxisomal fission. The encoded protein recruits dynamin-1-like protein (DNM1L) to mitochondria. There are multiple pseudogenes for this gene on chromosomes 1, 5, and X. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q567U1;Q658R6;Q9BVZ1;Q9H690;Q9NRG8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005777 peroxisome;GO:0031966 mitochondrial membrane;GO:0008021 synaptic vesicle",
        "go_biological_process": "GO:0016559 peroxisome fission;GO:0006626 protein targeting to mitochondrion;GO:0007005 mitochondrion organization;GO:0000266 mitochondrial fission;GO:0090141 positive regulation of mitochondrial fission",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q9GZY8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NJ78-1",
        "uniprot_id": [
            {
                "id": "MET15_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NJ78",
                "type": "external"
            }
        ],
        "mass": 46121.0,
        "length": 407,
        "protein_name": "12S rRNA N(4)-cytidine methyltransferase METTL15",
        "gene_name": "METTL15",
        "organism": "Human",
        "refseq_name": "12S rRNA N(4)-cytidine methyltransferase METTL15 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001107000",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001107000",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL15; METT5D1",
        "gene_names_refseq": "METT5D1; METTL15",
        "protein_names_uniprotkb": "12S rRNA N(4)-cytidine methyltransferase METTL15; 12S rRNA m4C methyltransferase; 2.1.1.-; Methyltransferase 5 domain-containing protein 1; Methyltransferase-like protein 15",
        "protein_names_refseq": "12S rRNA N(4)-cytidine methyltransferase METTL15 isoform 1; 12S rRNA N(4)-cytidine methyltransferase METTL15; 12S rRNA N4-methylcytidine (m4C) methyltransferase; 12S rRNA m4C methyltransferase; methyltransferase 5 domain containing 1; methyltransferase 5 domain-containing protein 1; methyltransferase like 15; probable S-adenosyl-L-methionine-dependent methyltransferase METT5D1; probable methyltransferase-like protein 15; putative S-adenosyl-L-methionine-dependent methyltransferase METT5D1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:196074)",
        "pathway_count": 1,
        "publication_count": 36,
        "publication_id_list": "11237011;23186163;23481700;25645385;26992070;27846572;28832583;29242379;29351928;29393594;29557506;29632046;30315122;30429286;31665743;31844290;32157095;32371392;32387766;32938616;32983136;33141586;33298915;33392160;33936100;34087483;34171305;34405274;34509645;34932366;35051231;36284347;37715994;38913872;39894887;40596516",
        "class_list": "",
        "function": "Circular RNA METTL15/miR-374a-5p/ESCO2 axis induces colorectal cancer development., [RefSeq, PubMed]; N4-methylcytidine (m4C) methyltransferase responsible for the methylation of position C839 in mitochondrial 12S rRNA (PubMed:31665743, PubMed:32371392). Involved in the stabilization of 12S rRNA folding, therefore facilitating the assembly of the mitochondrial small ribosomal subunits (PubMed:31665743, PubMed:32371392)., [UniProtKB, PubMed, PubMed]; The catalytic activity of methyltransferase METTL15 is dispensable for its role in mitochondrial ribosome biogenesis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MRS5;B7WNU2;Q3MHD3;Q8N601;Q8NBA7",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity;GO:0008168 methyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0070475 rRNA base methylation;GO:0180026 mitochondrial small ribosomal subunit assembly;GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "A6NJ78-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86XA0-1",
        "uniprot_id": [
            {
                "id": "MET23_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86XA0",
                "type": "external"
            }
        ],
        "mass": 21469.0,
        "length": 190,
        "protein_name": "Histone-arginine methyltransferase METTL23",
        "gene_name": "METTL23",
        "organism": "Human",
        "refseq_name": "histone-arginine methyltransferase METTL23 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001073979",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073979",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL23; C17orf95",
        "gene_names_refseq": "C17orf95; METTL23; MRT44",
        "protein_names_uniprotkb": "Histone-arginine methyltransferase METTL23; 2.1.1.319; Methyltransferase-like protein 23",
        "protein_names_refseq": "histone-arginine methyltransferase METTL23 isoform 1; histone-arginine methyltransferase METTL23; methyltransferase like 23; methyltransferase-like protein 23; probable methyltransferase-like protein 23; spike binding protein 1",
        "tax_id": 9606,
        "disease": "autosomal recessive intellectual developmental disorder 44 (Disease Ontology:DOID:0081208); glaucoma (Disease Ontology:DOID:1686)",
        "pathway": " (hsa:124512);  (R-HSA-9821002);  (R-HSA-9821993)",
        "pathway_count": 3,
        "publication_count": 22,
        "publication_id_list": "11237011;17320160;17320161;17320163;17363312;17713478;17851529;18003914;22362753;22420752;23349634;24501276;24626631;25576301;29789417;31844290;32067349;32357974;32439618;32878022;33981976;35314832",
        "class_list": "",
        "function": "Exome sequencing revealed a novel homozygous METTL23 gene mutation leading to familial mild intellectual disability with dysmorphic features., [RefSeq, PubMed]; Further delineation of METTL23-associated intellectual disability., [RefSeq, PubMed]; Histone methyltransferase that dimethylates histone H3 at 'Arg-17', forming asymmetric dimethylarginine (H3R17me2a), leading to activate transcription via chromatin remodeling (By similarity). Maternal factor involved in epigenetic chromatin reprogramming of the paternal genome in the zygote: mediates H3R17me2a, promoting histone H3.3 incorporation in the male pronucleus, leading to TET3 recruitment and subsequent DNA demethylation (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; METTL23 mutations cause mild nonsyndromic autosomal recessive intellectual disability in two unrelated families, one from Austria, the other from Pakistan., [RefSeq, PubMed]; METTL23, a transcriptional partner of GABPA, is essential for human cognition, [RefSeq, PubMed]; The protein encoded by this gene functions as a transcription factor regulator in the transcriptional pathway for human cognition. It is a partner of the alpha subunit of the GA-binding protein transcription factor. Mutations in this gene cause mild autosomal recessive intellectual disability. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]., [RefSeq]; Two Cases of Recessive Intellectual Disability Caused by NDST1 and METTL23 Variants. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "H9ZYJ0;K7EK32",
        "ec_number_list": [
            {
                "id": "1.14.11.80",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.80",
                "type": "external"
            },
            {
                "id": "2.1.1.319",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.319",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0031072 heat shock protein binding;GO:0035242 protein-arginine omega-N asymmetric methyltransferase activity;GO:0035642 histone H3R17 methyltransferase activity;GO:0140297 DNA-binding transcription factor binding;GO:0008168 methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0001939 female pronucleus;GO:0001940 male pronucleus;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0050890 cognition;GO:0032259 methylation;GO:0040029 epigenetic regulation of gene expression;GO:0044727 epigenetic programing of male pronucleus",
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    },
    {
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        "uniprot_id": [
            {
                "id": "PIAS3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y6X2",
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            }
        ],
        "mass": 68017.0,
        "length": 628,
        "protein_name": "E3 SUMO-protein ligase PIAS3",
        "gene_name": "PIAS3",
        "organism": "Human",
        "refseq_name": "E3 SUMO-protein ligase PIAS3",
        "refseq_ac": [
            {
                "id": "NP_006090",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006090",
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            }
        ],
        "gene_names_uniprotkb": "PIAS3",
        "gene_names_refseq": "PIAS3; ZMIZ5",
        "protein_names_uniprotkb": "E3 SUMO-protein ligase PIAS3; 2.3.2.-; E3 SUMO-protein transferase PIAS3; Protein inhibitor of activated STAT protein 3",
        "protein_names_refseq": "E3 SUMO-protein ligase PIAS3; E3 SUMO-protein transferase PIAS3; protein inhibitor of activated STAT protein 3; zinc finger, MIZ-type containing 5",
        "tax_id": 9606,
        "disease": "hematologic cancer (Disease Ontology:DOID:2531)",
        "pathway": " (hsa:10401);  (R-HSA-3232118);  (R-HSA-3899300);  (R-HSA-4090294);  (R-HSA-4615885);  (R-HSA-4755510);  (R-HSA-5696395)",
        "pathway_count": 7,
        "publication_count": 229,
        "publication_id_list": "10319586;10526214;10734143;10759568;10862613;11007478;11060035;11071847;11121022;11124955;11141066;11237011;11278856;11477070;11511374;11709553;11842083;12072434;12077349;12080057;12144530;12149243;12150977;12177000;12356736;12419227;12529333;12679040;12718889;12832072;14500761;14517266;14651848;14715251;15192080;15192092;15208321;15220921;15247228;15494207;15507434;15590680;15766567;15923626;15931174;15958389;15961505;15976810;15989970;16030353;16098147;16491090;16757475;16781829;16906147;16912044;17000769;17020914;17079232;17081986;17105732;17183683;17218271;17283066;17298944;17314004;17369852;17466625;17466626;17535915;17717077;17803295;17942393;17948053;18082607;18211901;18339323;18374648;18381449;18394993;18488044;18614043;18617891;18617892;18946085;19041634;19056823;19211567;19240082;19297320;19596686;19615980;19661379;19692572;19713942;19744555;19850744;19864602;19940136;19941824;19955185;19995069;20016603;20098713;20159957;20176810;20188669;20209145;20368362;20516148;20547755;20663916;20676127;20719936;20876134;21098080;21167178;21338522;21375726;21467194;21527249;21554500;21900752;21965678;22022399;22081108;22457066;22464730;22467880;22649547;22713328;22869377;22930759;23038248;23045548;23352696;23404503;23417673;23481700;23546875;23673342;23751493;24366607;24390485;24651376;24782567;24835590;25074923;25114211;25154395;25218447;25406032;25418920;25538220;25576301;25645385;25772364;25800734;25892735;26042670;26073453;26151477;26154972;26811146;26929215;26992070;27600516;27935866;28218747;28228285;28832583;28834231;28842558;28904123;29070839;29242379;29393594;29437277;29557506;29632046;29786170;30315122;30410026;30779550;31154438;31530632;31741759;31844290;31848261;31998317;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33912179;33968037;34030529;34087483;34171305;34185709;34509645;34837964;35051231;35318648;35580925;36010968;36284347;37938771;38665916;39223673;7559382;7700386;8692841;9130708;9388184;9699634;9716411;9734360;9771713",
        "class_list": "",
        "function": "Crosstalk between PKA and PIAS3 regulates cardiac Kv4 channel SUMOylation. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway and the steroid hormone signaling pathway. Involved in regulating STAT3 signaling via inhibiting STAT3 DNA-binding and suppressing cell growth. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation (PubMed:21965678, PubMed:9388184). Sumoylates CCAR2 which promotes its interaction with SIRT1 (PubMed:25406032). Diminishes the sumoylation of ZFHX3 by preventing the colocalization of ZFHX3 with SUMO1 in the nucleus (PubMed:24651376)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; LncRNA FOXD2-AS1 promotes cell proliferation and invasion of fibroblast-like synoviocytes by regulation of miR-331-3p/PIAS3 pathway in rheumatoid arthritis., [RefSeq, PubMed]; PIAS3 suppresses damage in an Alzheimer's disease cell model by inducing the STAT3-associated STAT3/Nestin/Nrf2/HO-1 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the PIAS [protein inhibitor of activated STAT (signal transducer and activator of transcription)] family of transcriptional modulators. The protein functions as a SUMO (small ubiquitin-like modifier)-E3 ligase which catalyzes the covalent attachment of a SUMO protein to specific target substrates. It directly binds to several transcription factors and either blocks or enhances their activity. Alternatively spliced transcript variants of this gene have been identified, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
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        "secondary_ac_list": "Q9UFI3",
        "ec_number_list": [
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                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
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            {
                "id": "2.4.2.-",
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            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.30",
                "type": "external"
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            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
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            {
                "id": "1.14.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
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            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
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            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
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        ],
        "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0008270 zinc ion binding;GO:0003712 transcription coregulator activity;GO:0019789 SUMO transferase activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0000785 chromatin;GO:0099523 presynaptic cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016925 protein sumoylation;GO:0033235 positive regulation of protein sumoylation;GO:0033234 negative regulation of protein sumoylation",
        "synthesized_glycan_count": 0,
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    },
    {
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        "uniprot_id": [
            {
                "id": "PAGE2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z2X7",
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        ],
        "mass": 12090.0,
        "length": 111,
        "protein_name": "P antigen family member 2",
        "gene_name": "PAGE2",
        "organism": "Human",
        "refseq_name": "P antigen family member 2",
        "refseq_ac": [
            {
                "id": "NP_997222",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997222",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PAGE2; GAGEC2; GAGEE2",
        "gene_names_refseq": "CT16.4; GAGEC2; GAGEE2; PAGE-2; PAGE2",
        "protein_names_uniprotkb": "P antigen family member 2; G antigen family C 2; PAGE-2; Prostate-associated gene 2 protein",
        "protein_names_refseq": "G antigen family C 2; G antigen, family E, 2; P antigen family member 2; P antigen family, member 2 (prostate associated); g antigen family E member 2; prostate-associated gene 2 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:203569)",
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        "publication_count": 4,
        "publication_id_list": "11237011;25229454;32157095;32938616",
        "class_list": "",
        "function": "Epigenetic mechanisms underlying the dynamic expression of cancer-testis genes, PAGE2, -2B and SPANX-B, during mesenchymal-to-epithelial transition Publication Status: Online-Only, [RefSeq, PubMed]",
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        "secondary_ac_list": "Q5JRK7;Q5JRK8",
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    {
        "uniprot_canonical_ac": "P04271-1",
        "uniprot_id": [
            {
                "id": "S100B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P04271",
                "type": "external"
            }
        ],
        "mass": 10713.0,
        "length": 92,
        "protein_name": "Protein S100-B",
        "gene_name": "S100B",
        "organism": "Human",
        "refseq_name": "protein S100-B",
        "refseq_ac": [
            {
                "id": "NP_006263",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006263",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "S100B",
        "gene_names_refseq": "NEF; S100-B; S100B; S100beta; S100",
        "protein_names_uniprotkb": "Protein S100-B; S-100 protein beta chain; S-100 protein subunit beta; S100 calcium-binding protein B",
        "protein_names_refseq": "S-100 calcium-binding protein, beta chain; S-100 protein subunit beta; S100 calcium-binding protein, beta (neural); protein S100-B",
        "tax_id": 9606,
        "disease": "sleep apnea (Disease Ontology:DOID:0050847); stroke (Disease Ontology:DOID:0051061); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); asphyxia neonatorum (Disease Ontology:DOID:11088); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); migraine without aura (Disease Ontology:DOID:12783); dilated cardiomyopathy (Disease Ontology:DOID:12930); aspergillosis (Disease Ontology:DOID:13564); Machado-Joseph disease (Disease Ontology:DOID:1440); depressive disorder (Disease Ontology:DOID:1596); brain ischemia (Disease Ontology:DOID:2316); West Nile fever (Disease Ontology:DOID:2366); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); demyelinating disease (Disease Ontology:DOID:3213); bipolar disorder (Disease Ontology:DOID:3312); middle cerebral artery infarction (Disease Ontology:DOID:3525); brain edema (Disease Ontology:DOID:4724); borna disease (Disease Ontology:DOID:5154); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844); neuromyelitis optica (Disease Ontology:DOID:8869); brain disease (Disease Ontology:DOID:936); bacterial meningitis (Disease Ontology:DOID:9470)",
        "pathway": " (hsa:6285);  (R-HSA-1251985);  (R-HSA-445989);  (R-HSA-879415);  (R-HSA-933542)",
        "pathway_count": 5,
        "publication_count": 56,
        "publication_id_list": "10531386;10723127;11237011;11679632;12221085;12470955;12480931;12807903;12935895;15023535;15145317;15534001;16056267;16061658;1651976;16912174;17018285;17047224;17728323;18462684;18653779;19047365;19531498;19596786;19666475;20351179;20943659;20950652;22399290;23230144;2394738;24308844;24829397;25516468;27600516;27618915;27701768;29557506;30429286;30817223;31844290;32157095;32488085;33831707;38160207;38255850;38357151;38485004;4031854;6487634;8529130;9008162;9519411;9689078;9865693;9925766",
        "class_list": "",
        "function": "Application value of serum S100B combined with glucose metabolism indexes in predicting adverse pregnancy outcomes of patients with severe preeclampsia., [RefSeq, PubMed]; Effects of interventional vascular embolization at different timing on prognosis and serum S100 calcium-binding protein B level of patients with aneurysmal subarachnoid hemorrhage., [RefSeq, PubMed]; Serum S100B protein and white matter changes in schizophrenia before and after medication., [RefSeq, PubMed]; Small zinc- and- and calcium-binding protein that is highly expressed in astrocytes and constitutes one of the most abundant soluble proteins in brain (PubMed:20950652, PubMed:6487634). Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer (PubMed:20950652, PubMed:6487634). Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites (By similarity). Acts as a neurotrophic factor that promotes astrocytosis and axonal proliferation (By similarity). Involved in innervation of thermogenic adipose tissue by acting as an adipocyte-derived neurotrophic factor that promotes sympathetic innervation of adipose tissue (By similarity). Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase (By similarity). Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling (By similarity). Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization (PubMed:20351179). May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity (PubMed:22399290)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; The Multifaceted S100B Protein: A Role in Obesity and Diabetes? Review article Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 21q22.3. This protein may function in Neurite extension, proliferation of melanoma cells, stimulation of Ca2+ fluxes, inhibition of PKC-mediated phosphorylation, astrocytosis and axonal proliferation, and inhibition of microtubule assembly. Chromosomal rearrangements and altered expression of this gene have been implicated in several neurological, neoplastic, and other types of diseases, including Alzheimer's disease, Down's syndrome, epilepsy, amyotrophic lateral sclerosis, melanoma, and type I diabetes. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "secondary_ac_list": "D3DSN6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0050786 RAGE receptor binding;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0048708 astrocyte differentiation;GO:0097490 sympathetic neuron projection extension;GO:0007155 cell adhesion;GO:0007409 axonogenesis;GO:0007611 learning or memory",
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        "hit_score": 5.7,
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        "uniprot_id": [
            {
                "id": "RS7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P62081",
                "type": "external"
            }
        ],
        "mass": 22127.0,
        "length": 194,
        "protein_name": "Small ribosomal subunit protein eS7",
        "gene_name": "RPS7",
        "organism": "Human",
        "refseq_name": "small ribosomal subunit protein eS7",
        "refseq_ac": [
            {
                "id": "NP_001002",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RPS7",
        "gene_names_refseq": "DBA8; RPS7; S7; eS7",
        "protein_names_uniprotkb": "Small ribosomal subunit protein eS7; 40S ribosomal protein S7",
        "protein_names_refseq": "40S ribosomal protein S7; small ribosomal subunit protein eS7",
        "tax_id": 9606,
        "disease": "Diamond-Blackfan anemia 8 (Disease Ontology:DOID:0111881)",
        "pathway": " (hsa:6201);  (R-HSA-156827);  (R-HSA-156902);  (R-HSA-1799339);  (R-HSA-192823);  (R-HSA-2408557);  (R-HSA-6790901);  (R-HSA-6791226);  (R-HSA-72649);  (R-HSA-72689);  (R-HSA-72695);  (R-HSA-72702);  (R-HSA-72706);  (R-HSA-72764);  (R-HSA-9010553);  (R-HSA-9633012);  (R-HSA-9735869);  (R-HSA-9754678);  (R-HSA-975956);  (R-HSA-975957);  (R-HSA-9954714);  (R-HSA-9954716)",
        "pathway_count": 22,
        "publication_count": 333,
        "publication_id_list": "10358005;10364207;10380706;10606270;10659855;1095581;10970870;10982836;11018020;11018027;1104615;11081632;11237011;11265756;11331269;11532962;11544179;11546874;11551508;11677247;11691921;11726970;11823430;11922599;11935223;11964406;11978965;12068309;12150911;12417715;12417735;12493757;12554878;12588972;12718880;12832468;12853463;1400365;14527413;14567916;14630918;14636577;14654843;14742663;14973490;14978097;15034551;15199136;15317934;15385533;15534230;15546618;15721257;15775988;15781252;15821744;16026328;16037817;16043514;16186820;16209946;16284618;16381836;16452507;16469117;16601204;16622410;16630668;16738141;16782898;16912115;16989641;17053788;17081983;17142313;17189298;17267404;17352659;17353269;17363904;17412707;17636026;17726049;17803942;17893241;18065403;18066079;18166647;18230761;18256688;18285520;18423202;18438418;18447580;18447585;18448518;18455985;18524595;18539146;1856230;1861871;18657639;18669648;18974281;19033376;19060897;19061985;19106111;19150429;19332556;19359157;19417104;19463982;19478851;19503078;19556969;19564402;19608861;19608919;19706539;19801658;19838190;19859661;19909264;20023408;20038530;20047967;20056613;2006156;20361218;20444697;20479275;20531386;20691628;20798176;20805244;20817927;20819938;20873783;20930030;21029861;21036871;21063389;21097556;21145460;21419344;21740066;22072790;22121020;22174690;22190735;22195017;22299025;22424782;22855488;22916032;23035226;23085078;23217742;23234702;23269699;23391857;23439679;23481700;23482395;23636399;23746841;2388630;24086612;24366607;24424021;24524803;24550520;24714562;24715725;25132172;25242263;25411247;25418920;25432065;25525153;25576301;25645385;25653167;25810538;25851604;25969445;26085946;26154972;26196125;26237581;26375851;26728094;26758079;26992070;27084949;27397612;27452731;27526673;27600516;27846572;27862975;27920218;28063628;28065601;28132843;28228285;28467828;28483520;28514659;28685749;28832583;28834231;29242379;29314611;29331515;29393594;29413899;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;29930882;30293783;30315122;30410026;30429286;30484775;30524438;30804176;31154438;31217245;31530632;31844290;32099016;32119511;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32579943;32680882;32897882;32908316;32938616;32983136;32995776;32995777;33043033;33080218;33091337;33141586;33188728;33214551;33268501;33298915;33392160;33479166;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34315815;34357683;34373319;34509645;34516797;34561969;34624207;34725712;34932366;35051231;35138101;35251023;35318648;35561310;35580925;35871033;36010968;36057918;36215666;36241641;36284347;36302773;36610391;37217939;37938771;38326908;38665916;40914422;40930100;429297;592398;592399;641056;6568109;6853548;6901506;7000367;7734418;7990965;8336711;8407925;8522193;8706699;8890909;8943342;9045610;9211906;9211966;9431993;9482744;9512526;9631292;9637248;9687515;9712840;9732867;9857202",
        "class_list": "",
        "function": "Component of the small ribosomal subunit (PubMed:23636399). The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:23636399). Required for rRNA maturation (PubMed:19061985). Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome (PubMed:34516797)., [UniProtKB, PubMed, PubMed, PubMed]; Missense mutation in RPS7 causes Diamond-Blackfan anemia via alteration of erythrocyte metabolism, protein translation and induction of ribosomal stress., [RefSeq, PubMed]; RNA-binding protein RPS7 promotes hepatocellular carcinoma progression via LOXL2-dependent activation of ITGB1/FAK/SRC signaling. Erratum:[J Exp Clin Cancer Res. 2024 Mar 14;43(1):80. doi: 10.1186/s13046-024-02999-9. PMID: 38481346] Publication Status: Online-Only, [RefSeq, PubMed]; Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 40S subunit. The protein belongs to the S7E family of ribosomal proteins. It is located in the cytoplasm. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome. [provided by RefSeq, Jul 2008]., [RefSeq]; Splice-site variant in the RPS7 5'-UTR leads to a decrease in the mRNA level and development of Diamond-Blackfan anemia., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P23821;P24818;Q57Z92;Q6IPH1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0019901 protein kinase binding;GO:0003730 mRNA 3'-UTR binding;GO:1990948 ubiquitin ligase inhibitor activity;GO:0048027 mRNA 5'-UTR binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005813 centrosome",
        "go_biological_process": "GO:0006412 translation;GO:0006364 rRNA processing;GO:2000059 negative regulation of ubiquitin-dependent protein catabolic process;GO:0002181 cytoplasmic translation;GO:1902255 positive regulation of intrinsic apoptotic signaling pathway by p53 class mediator",
        "synthesized_glycan_count": 0,
        "hit_score": 33.6,
        "record_id": "P62081-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NHS3-1",
        "uniprot_id": [
            {
                "id": "MFSD8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NHS3",
                "type": "external"
            }
        ],
        "mass": 57628.0,
        "length": 518,
        "protein_name": "Major facilitator superfamily domain-containing protein 8",
        "gene_name": "MFSD8",
        "organism": "Human",
        "refseq_name": "major facilitator superfamily domain-containing protein 8 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_689991",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689991",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MFSD8; CLN7",
        "gene_names_refseq": "CCMD; CLN7; MFSD8; SLC74A1",
        "protein_names_uniprotkb": "Major facilitator superfamily domain-containing protein 8; Ceroid-lipofuscinosis neuronal protein 7",
        "protein_names_refseq": "ceroid-lipofuscinosis, neuronal 7, late infantile; major facilitator superfamily domain-containing protein 8 isoform 1; major facilitator superfamily domain-containing protein 8",
        "tax_id": 9606,
        "disease": "neuronal ceroid lipofuscinosis 7 (Disease Ontology:DOID:0110722); macular dystrophy with central cone involvement (MONDO:MONDO:0014515)",
        "pathway": " (hsa:256471)",
        "pathway_count": 1,
        "publication_count": 55,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;17564970;17897319;18850119;19177532;19201763;19277732;20406422;21990111;22612257;23481700;25227500;25645385;26992070;27600516;28218747;28228285;28832583;29242379;29437277;29557506;30315122;30410026;30524438;31844290;32157095;32350084;32357974;32387766;32488085;32938616;32983136;33141586;33298915;33537174;33592498;33691108;33968037;33981976;34087483;34171305;34211107;34357683;34509645;34910516;35051231;35087090;35216386;35457110;35580925;36010968;36215666;38665916;39108195",
        "class_list": "",
        "function": "A Novel, Apparently Silent Variant in MFSD8 Causes Neuronal Ceroid Lipofuscinosis with Marked Intrafamilial Variability. Publication Status: Online-Only, [RefSeq, PubMed]; Aberrant upregulation of the glycolytic enzyme PFKFB3 in CLN7 neuronal ceroid lipofuscinosis. Publication Status: Online-Only, [RefSeq, PubMed]; Contribution of Whole-Genome Sequencing and Transcript Analysis to Decipher Retinal Diseases Associated with MFSD8 Variants. Publication Status: Online-Only, [RefSeq, PubMed]; MFSD8 gene is involved in late-infantile-onset neuronal ceroid lipofuscinose;it was mapped to chromosome 4q28.1-q28.2., [RefSeq, PubMed]; Maculopathy and adult-onset ataxia in patients with biallelic MFSD8 variants., [RefSeq, PubMed]; Outward-rectifying chloride channel involved in endolysosomal chloride homeostasis, membrane fusion and function. Conducts chloride currents up to hundreds of picoamperes. Regulates lysosomal calcium content by reducing the lysosomal membrane potential, thereby activating TRPML1 channel and further release of lysosomal calcium ions. Regulates the pH in endolysosomal compartments and may contribute to progressive acidification from endosome to lysosome. Permeable to other halides such as iodide and fluoride ions., [UniProtKB, PubMed]; This gene encodes a ubiquitous integral membrane protein that contains a transporter domain and a major facilitator superfamily (MFS) domain. Other members of the major facilitator superfamily transport small solutes through chemiosmotic ion gradients. The substrate transported by this protein is unknown. The protein likely localizes to lysosomal membranes. Mutations in this gene are correlated with a variant form of late infantile-onset neuronal ceroid lipofuscinoses (vLINCL). [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 2,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDM1;B7Z205;Q8N2P3",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            },
            {
                "id": "1.8.5.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.5.1",
                "type": "external"
            },
            {
                "id": "1.11.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005254 chloride channel activity;GO:0015111 iodide transmembrane transporter activity;GO:0062054 fluoride channel activity;GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005765 lysosomal membrane;GO:0010008 endosome membrane;GO:0034707 chloride channel complex;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0097352 autophagosome maturation;GO:0007040 lysosome organization",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q8NHS3-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100100000000.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13505-1",
        "uniprot_id": [
            {
                "id": "MTX1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13505",
                "type": "external"
            }
        ],
        "mass": 51463.0,
        "length": 466,
        "protein_name": "Metaxin-1",
        "gene_name": "MTX1",
        "organism": "Human",
        "refseq_name": "metaxin-1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_942584",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_942584",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MTX1; MTXN; MTX",
        "gene_names_refseq": "MTX1; MTXN; MTX",
        "protein_names_uniprotkb": "Metaxin-1; Mitochondrial outer membrane import complex protein 1",
        "protein_names_refseq": "metaxin-1 isoform 2; mitochondrial outer membrane import complex protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4580);  (R-HSA-1268020);  (R-HSA-8949613);  (R-HSA-9013404)",
        "pathway_count": 4,
        "publication_count": 151,
        "publication_id_list": "10381257;10847683;11145705;11149925;11237011;11704860;11919634;1464587;14675773;14726512;15023524;15169870;15254020;15542837;15644312;15683237;15814684;16081809;16185709;16243035;16243036;1660188;16777452;16849325;17060455;17121862;17158234;17214551;17269730;17510655;17624330;17698854;17765681;18056264;18174896;18191593;18323778;18662984;18678864;19409522;19453276;19767391;19962426;20112406;20593814;20833715;21151158;21378159;21750375;21836051;22114354;22252321;22864911;23041349;23255595;23481700;23597483;23757206;23811401;23870057;24098383;24623723;24687277;25285856;25315652;25418920;25621951;25645385;25764979;25781180;25862245;25997101;26016997;26416881;26477565;26530328;26697887;26968360;27479602;27481945;27485409;27623147;27845183;27920218;28063628;28218747;28228285;28832583;28834231;28855257;29242379;29393594;29493099;29508533;29557506;29632046;29786170;30315122;30410026;30524438;30779550;31154438;31222486;31389670;31530632;31644573;31844290;31848261;31871319;31937595;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34357683;34421355;34932366;35051231;35580925;36010968;36215666;36241641;36284347;37217939;37938771;7479768;8645157;8660965;9113980;9331372;9705280",
        "class_list": "",
        "function": "After the induction of apoptosis, Bak switches from its association with Mtx2 and VDAC2 to a closer association with Mtx1., [RefSeq, PubMed]; Genome-scale CRISPRa screening identifies MTX1 as a contributor for sorafenib resistance in hepatocellular carcinoma by augmenting autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in transport of proteins into the mitochondrion. Essential for embryonic development (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0A0MRK6;B1AVR9;B1AVS0;B2R9P4;Q9BUU3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0001401 SAM complex;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0016020 membrane;GO:0140275 MIB complex",
        "go_biological_process": "GO:0045040 protein insertion into mitochondrial outer membrane;GO:0015031 protein transport;GO:0007595 lactation;GO:0007007 inner mitochondrial membrane organization;GO:0070096 mitochondrial outer membrane translocase complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 15.4,
        "record_id": "Q13505-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UJH8-1",
        "uniprot_id": [
            {
                "id": "METRN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UJH8",
                "type": "external"
            }
        ],
        "mass": 31207.0,
        "length": 293,
        "protein_name": "Meteorin",
        "gene_name": "METRN",
        "organism": "Human",
        "refseq_name": "meteorin precursor",
        "refseq_ac": [
            {
                "id": "NP_076947",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076947",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METRN; C16orf23; RJD6",
        "gene_names_refseq": "C16orf23; METRN; c380A1.2",
        "protein_names_uniprotkb": "Meteorin",
        "protein_names_refseq": "meteorin precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79006)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "10.1038/emboj.2013.79;11237011;15085178;23584533;26121675;30524438;31844290;31859449;33141586;33867829",
        "class_list": "",
        "function": "Identification of low-dose radiation-induced exosomal circ-METRN and miR-4709-3p/GRB14/PDGFRalpha pathway as a key regulatory mechanism in Glioblastoma progression and radioresistance: Functional validation and clinical theranostic significance. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in both glial cell differentiation and axonal network formation during neurogenesis. Promotes astrocyte differentiation and transforms cerebellar astrocytes into radial glia. Also induces axonal extension in small and intermediate neurons of sensory ganglia by activating nearby satellite glia (By similarity)., [UniProtKB]; Meteorin plays important roles in both glial cell differentiation and axonal network formation during neurogenesis., [RefSeq, PubMed]; Meteorin regulates glial cell differentiation and promotes the formation of axonal networks during neurogenesis (Nishino et al., 2004 [PubMed 15085178]).[supplied by OMIM, Mar 2008]., [RefSeq]; Over expression of METRN predicts poor clinical prognosis in colorectal cancer., [RefSeq, PubMed]; The joint measurements of circulating METRN levels in the first trimester and systolic blood pressure and weight in the second trimester significantly increase the probabilities of predicting preeclampsia. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UJH9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005179 hormone activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005576 extracellular region",
        "go_biological_process": "GO:0050772 positive regulation of axonogenesis;GO:0010001 glial cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9UJH8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BTE0-1",
        "uniprot_id": [
            {
                "id": "NAT9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BTE0",
                "type": "external"
            }
        ],
        "mass": 23361.0,
        "length": 207,
        "protein_name": "Alpha/beta-tubulin-N-acetyltransferase 9",
        "gene_name": "NAT9",
        "organism": "Human",
        "refseq_name": "alpha/beta-tubulin-N-acetyltransferase 9 isoform 6",
        "refseq_ac": [
            {
                "id": "NP_001292011",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001292011",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAT9; EBS",
        "gene_names_refseq": "EBSP; NAT9; hNATL",
        "protein_names_uniprotkb": "Alpha/beta-tubulin-N-acetyltransferase 9; 2.3.1.308; Embryo brain-specific protein",
        "protein_names_refseq": "N-acetyltransferase 9 (GCN5-related, putative); N-acetyltransferase 9 (putative); alpha/beta-tubulin-N-acetyltransferase 9 isoform 6; alpha/beta-tubulin-N-acetyltransferase 9; embryo brain specific protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26151)",
        "pathway_count": 1,
        "publication_count": 42,
        "publication_id_list": "11237011;19139211;20031577;23481700;25418920;25576301;26154972;26929215;26992070;27600516;27846572;27920218;28218747;28904123;29242379;29393594;29437277;29493099;29557506;30410026;30484775;30833945;31844290;32157095;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33479178;33592498;33912179;33968037;34171305;34509645;36010968;36215666;36241641;37507384",
        "class_list": "",
        "function": "N-Acetyltransferase 9 ameliorates Abeta42-mediated neurodegeneration in the Drosophila eye. Publication Status: Online-Only, [RefSeq, PubMed]; N-acetyltransferase that mediates the acetylation of the N-terminal residues of alpha- and beta-tubulin., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; No evidence was found for association of SNPs mapping to the NAT9, SLC9A3R1 and RAPTOR loci with susceptibility to psoriatic arthritis, [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "B2R7F0;Q9BTD0;Q9Y3T3",
        "ec_number_list": [
            {
                "id": "2.3.1.308",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.308",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0120519 tubulin N-terminal-methionine acetyltransferase activity;GO:0008080 N-acetyltransferase activity",
        "go_cellular_component": "GO:0032991 protein-containing complex",
        "go_biological_process": "GO:1901673 regulation of mitotic spindle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q9BTE0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q49MG5-1",
        "uniprot_id": [
            {
                "id": "MAP9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q49MG5",
                "type": "external"
            }
        ],
        "mass": 74234.0,
        "length": 647,
        "protein_name": "Microtubule-associated protein 9",
        "gene_name": "MAP9",
        "organism": "Human",
        "refseq_name": "microtubule-associated protein 9",
        "refseq_ac": [
            {
                "id": "NP_001034669",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034669",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAP9; ASAP",
        "gene_names_refseq": "ASAP; MAP9",
        "protein_names_uniprotkb": "Microtubule-associated protein 9; Aster-associated protein",
        "protein_names_refseq": "aster-associated protein; microtubule-associated protein 9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79884)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "11237011;16049101;17525332;17925329;19413330;19690332;20615875;22672907;24715725;24876664;25576301;26992070;27846572;28649982;28832583;28834231;28904123;29242379;29557506;31217245;31662330;31844290;32151798;32157095;32268270;32357974;32387766;32938616;33309912;33392160;33592498;33912179;33936100;33968037;34171305;35051231;35494241;35580925;37938771;38159567",
        "class_list": "",
        "function": "ASAP is a human microtubule-associated protein required for bipolar spindle assembly and cytokinesis., [RefSeq, PubMed]; ASAP is a microtubule-associated protein required for spindle function, mitotic progression, and cytokinesis (Saffin et al., 2005 [PubMed 16049101]).[supplied by OMIM, Mar 2008]., [RefSeq]; ASAP stabilizes p53 both by alleviating MDM2-mediated p53 ubiquitination and by enhancing its p300-dependent acetylation., [RefSeq, PubMed]; Expression of MAP9 in Epstein-Barr virus-associated gastric carcinoma., [RefSeq, PubMed]; Involved in organization of the bipolar mitotic spindle. Required for bipolar spindle assembly, mitosis progression and cytokinesis. May act by stabilizing interphase microtubules., [UniProtKB, PubMed]; MAP9 Loss Triggers Chromosomal Instability, Initiates Colorectal Tumorigenesis, and Is Associated with Poor Survival of Patients with Colorectal Cancer., [RefSeq, PubMed]; MAP9 downregulation is associated with colorectal malignancy., [RefSeq, PubMed]; MAP9/ERCC3 signaling cascade: A new insight on understanding the chromosomal instability in hepatocellular carcinoma., [RefSeq, PubMed]; MAP9/MAPH-9 supports axonemal microtubule doublets and modulates motor movement., [RefSeq, PubMed]; Microtubule associated protein 9 inhibits liver tumorigenesis by suppressing ERCC3., [RefSeq, PubMed]; Results highlight dual ASAP regulation by Plk1 and further confirm the importance of ASAP for spindle pole organization, bipolar spindle assembly, and mitosis., [RefSeq, PubMed]; Study demonstrates that AurA-mediated phosphorylation of ASAP is essential to spindle formation and mitosis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 10,
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        "reported_snv": 4,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4W5I7;Q68DU1;Q9H781;Q9H7B6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0000235 astral microtubule;GO:0005737 cytoplasm;GO:0030424 axon;GO:0051233 spindle midzone;GO:0072686 mitotic spindle",
        "go_biological_process": "GO:0046602 regulation of mitotic centrosome separation;GO:0090307 mitotic spindle assembly;GO:0000281 mitotic cytokinesis;GO:0060236 regulation of mitotic spindle organization;GO:1902412 regulation of mitotic cytokinesis",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q49MG5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6BM72-1",
        "uniprot_id": [
            {
                "id": "MEG11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6BM72",
                "type": "external"
            }
        ],
        "mass": 110844.0,
        "length": 1044,
        "protein_name": "Multiple epidermal growth factor-like domains protein 11",
        "gene_name": "MEGF11",
        "organism": "Human",
        "refseq_name": "multiple epidermal growth factor-like domains protein 11 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_115821",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115821",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MEGF11; KIAA1781; PRO4432",
        "gene_names_refseq": "MEGF11",
        "protein_names_uniprotkb": "Multiple epidermal growth factor-like domains protein 11; Multiple EGF-like domains protein 11",
        "protein_names_refseq": "multiple EGF-like domains protein 11; multiple epidermal growth factor-like domains protein 11 isoform 2 precursor; multiple epidermal growth factor-like domains protein 11",
        "tax_id": 9606,
        "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); myopathy (Disease Ontology:DOID:423)",
        "pathway": " (hsa:84465)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;12975309;17498693;19851296;20198315;29393594;35398017;37120575",
        "class_list": "",
        "function": "May regulate the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Overexpression of multiple epidermal growth factor like domains 11 rescues anoikis survival through tumor cells-platelet interaction in triple negative breast Cancer cells., [RefSeq, PubMed]; Prenatal phthalate exposure and cord blood DNA methylation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
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        "reported_snv": 33,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q17R86;Q6UXS5;Q8ND91;Q96KG6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005201 extracellular matrix structural constituent",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0016323 basolateral plasma membrane;GO:0005604 basement membrane;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0034446 substrate adhesion-dependent cell spreading;GO:0010842 retina layer formation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "A6BM72-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5HYA8-1",
        "uniprot_id": [
            {
                "id": "MKS3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5HYA8",
                "type": "external"
            }
        ],
        "mass": 111745.0,
        "length": 995,
        "protein_name": "Meckelin",
        "gene_name": "TMEM67",
        "organism": "Human",
        "refseq_name": "meckelin isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001135773",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135773",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TMEM67; MKS3",
        "gene_names_refseq": "JBTS6; MECKELIN; MKS3; NPHP11; TMEM67; TNEM67",
        "protein_names_uniprotkb": "Meckelin; Meckel syndrome type 3 protein; Transmembrane protein 67",
        "protein_names_refseq": "meckel syndrome type 3 protein; meckelin isoform 2",
        "tax_id": 9606,
        "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); Meckel syndrome 3 (Disease Ontology:DOID:0070117); Bardet-Biedl syndrome 14 (Disease Ontology:DOID:0110136); autosomal recessive polycystic kidney disease (Disease Ontology:DOID:0110861); Joubert syndrome 6 (Disease Ontology:DOID:0111001); nephronophthisis 11 (Disease Ontology:DOID:0111118); COACH syndrome (Disease Ontology:DOID:0111589); portal hypertension (Disease Ontology:DOID:10762); meningocele (Disease Ontology:DOID:1088); hydrocephalus (Disease Ontology:DOID:10908); coloboma (Disease Ontology:DOID:12270); nephronophthisis (Disease Ontology:DOID:12712); communicating hydrocephalus (Disease Ontology:DOID:1573); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); cystic kidney disease (Disease Ontology:DOID:2975); proteinuria (Disease Ontology:DOID:576); RHYNS syndrome (MONDO:MONDO:0011202)",
        "pathway": " (hsa:91147);  (R-HSA-5620912)",
        "pathway_count": 2,
        "publication_count": 129,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12384791;16357211;16415887;17160906;17185389;17377820;17574030;17646400;17719545;18037885;18327255;18694559;18801063;19004860;19058225;19081074;19466712;19508969;19515853;19574260;19596800;19815549;19940019;20230748;20232449;20308558;20399632;20558667;21273506;21422230;21548880;21565611;21620453;21633164;21725307;21792235;22121117;22179047;22433857;22544926;22653444;23141531;23141541;23253480;23348840;23400999;23481700;23530209;23747070;23769972;23789104;24053599;24089205;24190977;24231678;24469809;24982133;25047611;25313408;25418920;25576301;25645385;25892735;26035863;26191240;26375851;26477546;26992070;27600516;27846572;27869121;28218747;28228285;28832583;28860541;28904123;29242379;29437277;29493099;29508533;29557506;29632711;29786170;29789417;29891882;30315122;30524438;31217245;31411728;31844290;32000717;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34357683;34405274;34509645;34731008;34932366;34964473;35051231;35154160;35580925;35621037;36010968;36241641;36284347;36334440;37074911;38844949",
        "class_list": "",
        "function": "Association of novel TMEM67 variants with mild phenotypes of high gamma-glutamyl transpeptidase cholestasis and congenital hepatic fibrosis., [RefSeq, PubMed]; Identified MKS3 mutations in four patients with JS, thus defining MKS3 as the sixth JS locus (JBTS6), [RefSeq, PubMed]; Mapping to chromosome 8 and possible role in Meckel-Gruber syndrome, [RefSeq, PubMed]; Positional cloning of the Wpk gene suggested a MKS3 candidate gene, TMEM67, for which we identified pathogenic mutations for five MKS3-linked consanguineous families., [RefSeq, PubMed]; Required for ciliary structure and function. Part of the tectonic-like complex which is required for tissue-specific ciliogenesis and may regulate ciliary membrane composition (By similarity). Involved in centrosome migration to the apical cell surface during early ciliogenesis. Involved in the regulation of cilia length and appropriate number through the control of centrosome duplication. Is a key regulator of stereociliary bundle orientation (By similarity). Required for epithelial cell branching morphology. Essential for endoplasmic reticulum-associated degradation (ERAD) of surfactant protein C (SFTPC). Involved in the negative regulation of canonical Wnt signaling, and activation of the non-canonical cascade stimulated by WNT5A (PubMed:26035863). In non-canonical Wnt signaling, it may act as ROR2 coreceptor (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; TMEM67 is required for the gating function of the transition zone that controls entry of membrane-associated proteins ARL13B and INPP5E into primary cilia., [RefSeq, PubMed]; The protein encoded by this gene localizes to the primary cilium and to the plasma membrane. The gene functions in centriole migration to the apical membrane and formation of the primary cilium. Multiple transcript variants encoding different isoforms have been found for this gene. Defects in this gene are a cause of Meckel syndrome type 3 (MKS3) and Joubert syndrome type 6 (JBTS6). [provided by RefSeq, Nov 2008]., [RefSeq]; Two novel TMEM67 variations in a Chinese family with recurrent pregnancy loss: a case report. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 19,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KRU5;B3KT47;G5E9H2;Q3ZCX3;Q7Z5T8;Q8IZ06",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051082 unfolded protein binding;GO:0031005 filamin binding",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005789 endoplasmic reticulum membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0036038 MKS complex;GO:0060170 ciliary membrane",
        "go_biological_process": "GO:0060271 cilium assembly;GO:0036503 ERAD pathway;GO:1904491 protein localization to ciliary transition zone;GO:0035567 non-canonical Wnt signaling pathway;GO:0010826 negative regulation of centrosome duplication",
        "synthesized_glycan_count": 0,
        "hit_score": 13.6,
        "record_id": "Q5HYA8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1000000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IW36-4",
        "uniprot_id": [
            {
                "id": "ZN695_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IW36",
                "type": "external"
            }
        ],
        "mass": 60149.0,
        "length": 515,
        "protein_name": "Zinc finger protein 695",
        "gene_name": "ZNF695",
        "organism": "Human",
        "refseq_name": "zinc finger protein 695 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001191150",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001191150",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZNF695",
        "gene_names_refseq": "SBZF3; ZNF695",
        "protein_names_uniprotkb": "Zinc finger protein 695; Zinc finger protein SBZF3",
        "protein_names_refseq": "zinc finger protein 695 isoform 2; zinc finger protein SBZF3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57116)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "23328677;25273507;26992070;28228285;31844290;33537174;35051231;36311753",
        "class_list": "",
        "function": "Identification of hub genes and their correlation with infiltration of immune cells in MYCN positive neuroblastoma based on WGCNA and LASSO algorithm. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]; ZNF695 methylation was associated with the response to definitive chemoradiotherapy in esophageal squamous cell carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T0N9;Q5T0P1;Q5T0P3;Q7Z2W8;Q7Z648",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q8IW36-4",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5SSG8-1",
        "uniprot_id": [
            {
                "id": "MUC21_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5SSG8",
                "type": "external"
            }
        ],
        "mass": 54228.0,
        "length": 566,
        "protein_name": "Mucin-21",
        "gene_name": "MUC21",
        "organism": "Human",
        "refseq_name": "mucin-21 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001309299",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309299",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MUC21; C6orf205; PRO1342",
        "gene_names_refseq": "C6orf205; KMQK697; MUC-21; MUC21",
        "protein_names_uniprotkb": "Mucin-21; Epiglycanin; MUC-21",
        "protein_names_refseq": "epiglycanin; mucin-21 isoform 2 precursor; mucin-21",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:394263);  (R-HSA-5083625);  (R-HSA-5083632);  (R-HSA-5083636);  (R-HSA-5621480);  (R-HSA-913709);  (R-HSA-977068)",
        "pathway_count": 7,
        "publication_count": 64,
        "publication_id_list": "10330415;10430883;10504389;10742600;10753916;11042166;11062056;11110698;11237011;11283017;11304796;11606584;11821425;12464682;12855678;12975309;1329093;14656219;15466199;15486459;15560372;15599692;15620693;15687324;16151858;16251947;16319059;17050534;17113861;17977904;18490740;18537974;18776906;18818202;19617566;20388707;21880719;22041900;22183981;22461326;23053572;23507963;23602766;2373995;24643043;25153226;30973916;35579188;35580925;37858248;38253038;7655172;8333853;8598452;8611500;8920913;8972730;9042338;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "",
        "function": "A CRISPR activation screen identifies MUC-21 as critical for resistance to NK and T cell-mediated cytotoxicity. Publication Status: Online-Only, [RefSeq, PubMed]; Identification and expression of human epiglycanin/MUC21: a novel transmembrane mucin, [RefSeq, PubMed]; MUC21 controls melanoma progression via regulating SLITRK5 and hedgehog signaling pathway., [RefSeq, PubMed]; MUC21 proteins with a specific glycosylation status may be involved in the progression of EGFR-mutated lung adenocarcinomas, particularly at the stage where tumors are transforming from pure lepidic to micropapillary through low papillary lepidic lesions. Publication Status: Online-Only, [RefSeq, PubMed]; Mucin 21/epiglycanin modulates cell adhesion, [RefSeq, PubMed]; This gene encodes a large membrane-bound glycoprotein which is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces. These proteins also play a role in intracellular signaling. The encoded protein contains an N-terminal signal sequence, an extracellular mucin domain, a stem domain, a transmembrane domain, and a C-terminal cytoplasmic tail domain. The mucin domain contains O-glycosylation sites and is polymorphic with isoforms containing a variable number of nonidentical proline-, threonine-, and serine-rich tandem repeats of 15 amino acids each. The aberrent expression of this gene is associated with lung adenocarcinoma. [provided by RefSeq, May 2017]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 49,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0UZT7;B4DQ55;C9JMK2;D9N007;Q0VGF1;Q3B7T2;Q5SS94;Q6UXC5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005796 Golgi lumen;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0022408 negative regulation of cell-cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q5SSG8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H825-1",
        "uniprot_id": [
            {
                "id": "METL8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H825",
                "type": "external"
            }
        ],
        "mass": 33387.0,
        "length": 291,
        "protein_name": "tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial",
        "gene_name": "METTL8",
        "organism": "Human",
        "refseq_name": "tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001308083",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308083",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL8",
        "gene_names_refseq": "METTL8; TIP",
        "protein_names_uniprotkb": "tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial; 2.1.1.-; Methyltransferase-like protein 8; mRNA N(3)-methylcytidine methyltransferase METTL8",
        "protein_names_refseq": "mRNA N(3)-methylcytidine methyltransferase METTL8; methyltransferase 8, methylcytidine; methyltransferase like 8; methyltransferase-like protein 8; tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial isoform 1; tRNA N(3)-cytidine methyltransferase METTL8, mitochondrial; tRNA N(3)-methylcytidine methyltransferase METTL8, mitochondrial; tension-induced/inhibited protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79828)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "11237011;17525332;25418920;25505266;25576301;27846572;28655767;28832583;28904123;29557506;31844290;32157095;32199293;32357974;33313824;33537174;33912179;34774131;35017528;35247384;35357504;36010968;36241641;37217939;37938771;38744809",
        "class_list": "",
        "function": "Data, including data from studies using mutant/knockout mice and cell lines from such mice, suggest that METTL2 and METTL6 (but not METTL8) contribute to post-transcriptional methylation of cytidine (formation of 3-methylcytidine) in tRNA; METTL2 methylates tRNA(Thr) and tRNA(Arg); METTL6 interacts with seryl-tRNA synthetase and methylates tRNA(Ser); METTL8 catalyzes post-transcriptional methylation of cytidine in mRNA., [RefSeq, PubMed]; METTL8 links mt-tRNA m[3]C modification to the HIF1alpha/RTK/Akt axis to sustain GBM stemness and tumorigenicity. Erratum:[Cell Death Dis. 2024 Jul 31;15(7):547. doi: 10.1038/s41419-024-06917-x. PMID: 39085240] Publication Status: Online-Only, [RefSeq, PubMed]; Methyltransferase METTL8 is required for 3-methylcytosine modification in human mitochondrial tRNAs., [RefSeq, PubMed]; Mitochondrial S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of mitochondrial tRNA(Ser)(UCN) and tRNA(Thr) (PubMed:34774131, PubMed:35017528). N(3)-methylcytidine methylation modification regulates mitochondrial translation efficiency and is required for activity of the respiratory chain (PubMed:34774131, PubMed:35017528). N(3)-methylcytidine methylation of mitochondrial tRNA(Ser)(UCN) requires the formation of N(6)-dimethylallyladenosine(37) (i6A37) by TRIT1 as prerequisite (PubMed:34774131, PubMed:35017528). May also mediate N(3)-methylcytidine modification of mRNAs (PubMed:28655767). The existence of N(3)-methylcytidine modification on mRNAs is however unclear, and additional evidences are required to confirm the role of the N(3)-methylcytidine-specific mRNA methyltransferase activity of METTL8 in vivo (PubMed:33313824, PubMed:34774131)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Molecular basis for human mitochondrial tRNA m3C modification by alternatively spliced METTL8., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent methyltransferase., [UniProtKB, UniProtKB]; The RNA methyltransferase METTL8 installs m(3)C32 in mitochondrial tRNAs(Thr/Ser(UCN)) to optimise tRNA structure and mitochondrial translation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53TM9;Q53TQ0",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008174 mRNA methyltransferase activity;GO:0052735 tRNA (cytidine-3-)-methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0004402 histone acetyltransferase activity;GO:0008173 RNA methyltransferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0005634 nucleus",
        "go_biological_process": "GO:0016071 mRNA metabolic process;GO:0070131 positive regulation of mitochondrial translation;GO:0070900 mitochondrial tRNA modification;GO:0106217 tRNA C3-cytosine methylation;GO:0008033 tRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q9H825-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UQ53-1",
        "uniprot_id": [
            {
                "id": "MGT4B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UQ53",
                "type": "external"
            }
        ],
        "mass": 63198.0,
        "length": 548,
        "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B",
        "gene_name": "MGAT4B",
        "organism": "Human",
        "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform 1",
        "refseq_ac": [
            {
                "id": "NP_055090",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055090",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MGAT4B; PRO1927",
        "gene_names_refseq": "GNT-IVB; GNT-IV; MGAT4B",
        "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B; 2.4.1.145; GlcNAc-T IVb; GnT-IVb; N-acetylglucosaminyltransferase IVb; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb",
        "protein_names_refseq": "N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVb; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVb; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase B isoform 1; alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; aminyltransferase; glcNAc-T IVb; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme B; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11282);  (R-HSA-9694548);  (R-HSA-975577)",
        "pathway_count": 3,
        "publication_count": 81,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10372966;10395745;10570912;10700233;10766765;11237011;11421344;11425186;11530204;11588157;11901181;12097641;12603328;12765789;12975309;15939404;16434023;16924681;17006639;17021253;1714903;17488527;18931531;19403558;19913121;20117844;20628086;22915798;23584533;25645385;25813380;25944901;26992070;27600516;27846572;27862975;27920218;28467828;28832583;28904123;29393594;29557506;29632711;29786170;30484775;31844290;32157095;32265295;32350084;32363391;32366695;32387766;32488085;32502341;32518941;32676595;32897882;32938616;33298915;33310888;33592498;33912179;33968037;34117209;34428449;34509645;34528721;34599882;34961524;34981577;35051231;35154160;35251023;35580925;36010968;7986008;9054414;9597550",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Analysis of expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer, [RefSeq, PubMed]; Glycosyltransferase that catalyzes the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (PubMed:10372966, PubMed:17006639). Prefers complex-type N-glycans over hybrid-types (PubMed:17006639). Has lower affinities for donors or acceptors than MGAT4A, suggesting that, under physiological conditions, it is not the main contributor in N-glycan biosynthesis (PubMed:17006639)., [UniProtKB, PubMed, PubMed]; GnT-IVa is more active than GnT-IVb under physiological conditions and it primarily contributes to the biosynthesis of N-glycans., [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme A, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1, 4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]., [RefSeq]; UDP-galactose (SLC35A2) and UDP-N-acetylglucosamine (SLC35A3) Transporters Form Glycosylation-related Complexes with Mannoside Acetylglucosaminyltransferases (Mgats)., [RefSeq, PubMed]; We investigated mRNA levels of glycosyltransferases, namely, N-acetylglucosaminyltransferase a (GnT)-IVb, and found that (GnT)-IVb expression was increased in HLE-cells Epirubicin resistant. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 622,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MPR0;Q86TF1;Q96GH4;Q9NSK6",
        "ec_number_list": [
            {
                "id": "2.4.1.155",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.155",
                "type": "external"
            },
            {
                "id": "2.4.1.68",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.68",
                "type": "external"
            },
            {
                "id": "2.4.1.145",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005783 endoplasmic reticulum;GO:0005795 Golgi stack;GO:0005793 endoplasmic reticulum-Golgi intermediate compartment",
        "go_biological_process": "GO:0019082 viral protein processing;GO:0009101 glycoprotein biosynthetic process;GO:0006487 protein N-linked glycosylation;GO:0006491 N-glycan processing",
        "synthesized_glycan_count": 3884,
        "hit_score": 9.0,
        "record_id": "Q9UQ53-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000010000.101.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UXD7-1",
        "uniprot_id": [
            {
                "id": "S49A3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UXD7",
                "type": "external"
            }
        ],
        "mass": 58427.0,
        "length": 560,
        "protein_name": "Solute carrier family 49 member A3",
        "gene_name": "SLC49A3",
        "organism": "Human",
        "refseq_name": "solute carrier family 49 member A3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001281270",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281270",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC49A3; LP2561; MFSD7; PRO717",
        "gene_names_refseq": "LP2561; MFSD7; SLC49A3",
        "protein_names_uniprotkb": "Solute carrier family 49 member A3; MYL5; Major facilitator superfamily domain-containing protein 7; Myosin light polypeptide 5 regulatory protein",
        "protein_names_refseq": "MYL5; major facilitator superfamily domain containing 7; major facilitator superfamily domain-containing protein 7; myosin light polypeptide 5 regulatory protein; solute carrier family 49 member A3 isoform 1; solute carrier family 49 member A3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84179)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;12975309;15498874;23481700;24715725;30620550;35051231;35580925",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 3,
        "predicted_c_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K7J5;Q6XYD4;Q8N6H1;Q9H6H6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q6UXD7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P22894-1",
        "uniprot_id": [
            {
                "id": "MMP8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P22894",
                "type": "external"
            }
        ],
        "mass": 53412.0,
        "length": 467,
        "protein_name": "Neutrophil collagenase",
        "gene_name": "MMP8",
        "organism": "Human",
        "refseq_name": "neutrophil collagenase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001291370",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291370",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MMP8; CLG1",
        "gene_names_refseq": "CLG1; HNC; MMP-8; MMP8; PMNL-CL",
        "protein_names_uniprotkb": "Neutrophil collagenase; 3.4.24.34; MMP-8; Matrix metalloproteinase-8; PMNL collagenase; PMNL-CL",
        "protein_names_refseq": "PMN leukocyte collagenase; PMNL collagenase; collagenase 2; matrix metalloproteinase 8 (neutrophil collagenase); matrix metalloproteinase-8; neutrophil collagenase isoform 2",
        "tax_id": 9606,
        "disease": "COVID-19 (Disease Ontology:DOID:0080600); thoracic aortic aneurysm (Disease Ontology:DOID:14004); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); endometrial carcinoma (Disease Ontology:DOID:2871); carotid artery disease (Disease Ontology:DOID:3407); brain infarction (Disease Ontology:DOID:3454); congestive heart failure (Disease Ontology:DOID:6000); rheumatoid arthritis (Disease Ontology:DOID:7148); abdominal aortic aneurysm (Disease Ontology:DOID:7693); osteoarthritis (Disease Ontology:DOID:8398)",
        "pathway": " (hsa:4317);  (R-HSA-1442490);  (R-HSA-1474228);  (R-HSA-1592389);  (R-HSA-6798695)",
        "pathway_count": 5,
        "publication_count": 155,
        "publication_id_list": "37639587;10049780;10229672;10386589;10551873;10706100;10809722;10986281;11013208;11119712;11237011;11375993;11577169;11830519;11872628;11927537;12579531;12727852;12843408;1311314;1330697;1371271;1390635;1480033;14973287;15005656;15234972;15257288;15591058;15950618;15958533;16133547;1649600;1662606;16631740;16825197;16825321;1698775;1704217;1707285;17088321;17332331;17354228;17608959;1783204;18434311;18622425;18658137;19010778;19571574;19657146;19714641;2005102;20142769;21030783;21297635;21441952;21593211;2159879;2164002;21670566;2169256;2169257;2169335;2176865;2176876;21784848;21864727;21935455;22159414;22241472;22382088;2253219;2269296;23035980;23650620;2383557;23845380;2537292;2546891;2548603;2551898;2557753;25645385;27600516;2834383;2845110;28668847;29557506;29599337;29769354;29808017;3038863;3058116;31154438;31222486;32157095;3223920;32488085;33254580;35051231;35580925;37074911;38419037;38433295;38937435;39197904;39361067;4216367;6258630;6263256;6270089;6694361;7075587;7547873;7656015;7669817;7746327;7780967;7826345;7890645;7890717;7896811;7981201;8015608;8137810;8194591;8226919;8307185;8314771;8463259;8530478;8576151;8621565;8626565;8645182;8663255;8692836;8804434;8920930;8999957;9065415;9092507;9115292;9148753;9249047;9261109;9346290;9422744;9461298;9578462;9632662;9651395;9655333;9852107",
        "class_list": "",
        "function": "Can degrade fibrillar type I, II, and III collagens., [UniProtKB]; Comparing the activity level of salivary matrix metalloproteinase-8 in patients with diabetes and moderate to severe chronic generalized periodontitis., [RefSeq, PubMed]; Impact of Matrix Metalloproteinase-8 Polymorphisms on Nasopharyngeal Carcinoma Risk., [RefSeq, PubMed]; Inhibition of MMP8 effectively alleviates manic-like behavior and reduces neuroinflammation by modulating astrocytic CEBPD. Publication Status: Online-Only, [RefSeq, PubMed]; Preliminary investigation of MMP8 (rs11225395) and MMP9 (rs3787268) polymorphisms association with breast cancer risk in pashtun women of Pakistan. Publication Status: Online-Only, [RefSeq, PubMed]; The adhesion-GPCR ADGRF5 fuels breast cancer progression by suppressing the MMP8-mediated antitumorigenic effects. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the matrix metalloproteinase (MMP) family of proteins. These proteins are involved in the breakdown of extracellular matrix in embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Proteolysis at different sites on this protein results in multiple active forms of the enzyme with distinct N-termini. This protein functions in the degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
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        "reported_n_glycosites": 2,
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        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
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        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 8030,
        "biomarker_type": "diagnostic; prognostic",
        "glycan_count": 3,
        "disease_count": 11,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q45F99",
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                "id": "1.8.3.2",
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            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.35",
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            {
                "id": "3.4.24.-",
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            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13",
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            {
                "id": "3.4.23.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.5",
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            {
                "id": "3.4.21.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.4",
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            {
                "id": "3.4.21.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.37",
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            {
                "id": "3.4.24.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17",
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                "id": "2.3.1.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.16",
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            {
                "id": "2.3.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.9",
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            {
                "id": "2.3.1.155",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.155",
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            {
                "id": "3.4.24.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23",
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            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22",
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            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.6",
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                "id": "3.4.11.4",
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            {
                "id": "3.4.24.35",
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                "id": "1.4.3.22",
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            {
                "id": "1.4.3.-",
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                "id": "3.4.21.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.35",
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                "id": "3.4.22.27",
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            {
                "id": "3.4.24.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65",
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            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "3.1.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-",
                "type": "external"
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            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.2.1.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.17",
                "type": "external"
            },
            {
                "id": "3.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.-",
                "type": "external"
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            {
                "id": "3.2.1.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.14",
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            {
                "id": "3.5.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.23",
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            {
                "id": "3.5.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-",
                "type": "external"
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            {
                "id": "3.5.1.109",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.109",
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            {
                "id": "2.3.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.5",
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            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
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            {
                "id": "3.4.19.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9",
                "type": "external"
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            {
                "id": "3.2.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.18",
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            {
                "id": "2.1.1.348",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348",
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            {
                "id": "2.1.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.9",
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            },
            {
                "id": "3.5.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.3",
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                "id": "3.4.18.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1",
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            {
                "id": "3.2.1.166",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.166",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0004222 metalloendopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008270 zinc ion binding;GO:0043120 tumor necrosis factor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0035580 specific granule lumen;GO:1904724 tertiary granule lumen",
        "go_biological_process": "GO:0006508 proteolysis;GO:0022617 extracellular matrix disassembly;GO:0030198 extracellular matrix organization;GO:1903980 positive regulation of microglial cell activation;GO:0071222 cellular response to lipopolysaccharide",
        "synthesized_glycan_count": 0,
        "hit_score": 16.1,
        "record_id": "P22894-1",
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        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "MRNIP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6NTE8",
                "type": "external"
            }
        ],
        "mass": 37743.0,
        "length": 343,
        "protein_name": "MRN complex-interacting protein",
        "gene_name": "MRNIP",
        "organism": "Human",
        "refseq_name": "MRN complex-interacting protein isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001017987",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001017987",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MRNIP; C5orf45",
        "gene_names_refseq": "C5orf45; MRNIP",
        "protein_names_uniprotkb": "MRN complex-interacting protein; MRN-interacting protein",
        "protein_names_refseq": "MRN complex-interacting protein isoform 2; MRN-interacting protein; UPF0544 protein C5orf45",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51149)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;25576301;26992070;27568553;28832583;28834231;28904123;29242379;29493099;30192525;30429286;31154438;31844290;31848261;32157095;33717175;33912179;34509645",
        "class_list": "",
        "function": "Plays a role in the cellular response to DNA damage and the maintenance of genome stability through its association with the MRN damage-sensing complex (PubMed:27568553). Promotes chromatin loading and activity of the MRN complex to facilitate subsequent ATM-mediated DNA damage response signaling and DNA repair (PubMed:27568553)., [UniProtKB]; These data reveal that MRNIP is an important component of the human DNA damage response., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MD09;E9PAK6;Q7Z3D8;Q9BUC1;Q9UN54",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006281 DNA repair;GO:0045860 positive regulation of protein kinase activity;GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0007095 mitotic G2 DNA damage checkpoint signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 1.9,
        "record_id": "Q6NTE8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6PCD5-1",
        "uniprot_id": [
            {
                "id": "RFWD3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6PCD5",
                "type": "external"
            }
        ],
        "mass": 85094.0,
        "length": 774,
        "protein_name": "E3 ubiquitin-protein ligase RFWD3",
        "gene_name": "RFWD3",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase RFWD3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_060594",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060594",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RFWD3; RNF201",
        "gene_names_refseq": "FANCW; RFWD3; RNF201",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase RFWD3; 2.3.2.27; RING finger and WD repeat domain-containing protein 3; RING finger protein 201",
        "protein_names_refseq": "E3 ubiquitin-protein ligase RFWD3 isoform 1; E3 ubiquitin-protein ligase RFWD3; RING finger and WD repeat domain-containing protein 3; RING finger protein 201; RING-type E3 ubiquitin transferase RFWD3",
        "tax_id": 9606,
        "disease": "Fanconi anemia complementation group W (Disease Ontology:DOID:0060978)",
        "pathway": " (hsa:55159)",
        "pathway_count": 1,
        "publication_count": 83,
        "publication_id_list": "11237011;17081983;17525332;18077418;18669648;19844255;20173098;21504906;21558276;22424782;22544926;22898188;23481700;24397554;24715725;25418920;25505266;25576301;25880248;26154972;26474068;26992070;27600516;27846572;27893789;27920218;28218747;28228285;28575657;28575658;28691929;28832583;28904123;29242379;29393594;29437277;29493099;29557506;29786170;30315122;30484775;30524438;30833945;31217245;31222486;31530632;31844290;31900333;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;33044890;33141586;33298915;33321094;33392160;33592498;33633747;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34509645;34561969;35051231;35561310;35580925;35830250;36010968;36215666;36241641;37036693;37938771",
        "class_list": "",
        "function": "E3 ubiquitin-protein ligase required for the repair of DNA interstrand cross-links (ICL) in response to DNA damage (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:33321094). Plays a key role in RPA-mediated DNA damage signaling and repair (PubMed:21504906, PubMed:21558276, PubMed:26474068, PubMed:28575657, PubMed:28575658, PubMed:28691929). Acts by mediating ubiquitination of the RPA complex (RPA1, RPA2 and RPA3 subunits) and RAD51 at stalled replication forks, leading to remove them from DNA damage sites and promote homologous recombination (PubMed:26474068, PubMed:28575657, PubMed:28575658). Also mediates the ubiquitination of p53/TP53 in the late response to DNA damage, and acts as a positive regulator of p53/TP53 stability, thereby regulating the G1/S DNA damage checkpoint (PubMed:20173098). May act by catalyzing the formation of short polyubiquitin chains on p53/TP53 that are not targeted to the proteasome (PubMed:20173098). In response to ionizing radiation, interacts with MDM2 and enhances p53/TP53 ubiquitination, possibly by restricting MDM2 from extending polyubiquitin chains on ubiquitinated p53/TP53 (PubMed:20173098). Required to translesion DNA synthesis across DNA-protein cross-link adducts by catalyzing ubiquitination of proteins on single-stranded DNA (ssDNA) (PubMed:33321094)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; RFWD3 promotes ZRANB3 recruitment to regulate the remodeling of stalled replication forks., [RefSeq, PubMed]; Systematic analysis on expression quantitative trait loci identifies a novel regulatory variant in ring finger and WD repeat domain 3 associated with prognosis of pancreatic cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The E3 ligase RFWD3 stabilizes ORC in a p53-dependent manner., [RefSeq, PubMed]; The ubiquitin ligase RFWD3 is required for translesion DNA synthesis., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K585;B2RE35;D3DUJ8;Q5XKR3;Q9H9Q3;Q9NVT4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0002039 p53 binding;GO:0097371 MDM2/MDM4 family protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0016605 PML body;GO:0090734 site of DNA damage",
        "go_biological_process": "GO:2000001 regulation of DNA damage checkpoint;GO:0006974 DNA damage response;GO:0010212 response to ionizing radiation;GO:0016567 protein ubiquitination;GO:0000724 double-strand break repair via homologous recombination",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "Q6PCD5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96QT6-1",
        "uniprot_id": [
            {
                "id": "PHF12_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96QT6",
                "type": "external"
            }
        ],
        "mass": 109698.0,
        "length": 1004,
        "protein_name": "PHD finger protein 12",
        "gene_name": "PHF12",
        "organism": "Human",
        "refseq_name": "PHD finger protein 12 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001028733",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028733",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHF12; KIAA1523",
        "gene_names_refseq": "PF1; PHF12",
        "protein_names_uniprotkb": "PHD finger protein 12; PHD factor 1; Pf1",
        "protein_names_refseq": "PHD factor 1; PHD finger protein 12 isoform 1; PHD zinc finger transcription factor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57649)",
        "pathway_count": 1,
        "publication_count": 68,
        "publication_id_list": "11237011;11390640;16565220;16893883;18452278;18669648;19413330;19664995;19690332;19691289;20068231;20305658;21041482;21406692;23186163;24275569;25218447;25418920;25755297;25772364;25880248;26992070;27543614;27862975;28218747;28411811;28832583;29242379;29393594;29437277;29786170;30315122;30397120;30429286;30484775;30779550;31154438;31530632;31844290;31848261;31998317;32157095;32350084;32357974;32387766;32488085;32502341;32938616;32938750;33592498;33968037;34019948;34171305;34846842;35051231;35251023;35254053;35289036;35580925;36010968;36241641;37137925;37340703;38253038;38665916;39075515;39302247;39531497",
        "class_list": "",
        "function": "PHF12 regulates HDAC1 to promote tumorigenesis via EGFR/AKT signaling pathway in non-small cell lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor acting as key scaffolding subunit of SIN3 complexes which contributes to complex assembly by contacting each core subunit domain, stabilizes the complex and constitutes the substrate receptor by recruiting the H3 histone tail (PubMed:37137925). SIN3 complexes are composed of a SIN3 scaffold subunit, one catalytic core (HDAC1 or HDAC2) and 2 chromatin targeting modules (PubMed:11390640, PubMed:37137925). SIN3B complex represses transcription and counteracts the histone acetyltransferase activity of EP300 through the recognition H3K27ac marks by PHF12 and the activity of the histone deacetylase HDAC2 (PubMed:37137925). SIN3B complex is recruited downstream of the constitutively active genes transcriptional start sites through interaction with histones and mitigates histone acetylation and RNA polymerase II progression within transcribed regions contributing to the regulation of transcription (PubMed:21041482). May also repress transcription in a SIN3A-independent manner through recruitment of functional TLE5 complexes to DNA (PubMed:11390640). May also play a role in ribosomal biogenesis (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 15,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 15,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 15,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 16,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0VAI5;Q2TAK2;Q6ZML2;Q9BV34;Q9H7U9;Q9P205",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0035091 phosphatidylinositol binding;GO:0001222 transcription corepressor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0070822 Sin3-type complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "Q96QT6-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99719-1",
        "uniprot_id": [
            {
                "id": "SEPT5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99719",
                "type": "external"
            }
        ],
        "mass": 42777.0,
        "length": 369,
        "protein_name": "Septin-5",
        "gene_name": "SEPTIN5",
        "organism": "Human",
        "refseq_name": "septin-5 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001009939",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009939",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SEPTIN5; PNUTL1; SEPT5",
        "gene_names_refseq": "CDCREL-1; CDCREL1; CDCREL; H5; HCDCREL-1; PNUTL1; SEPT5; SEPTIN5; Septin-5",
        "protein_names_uniprotkb": "Septin-5; CDCrel-1; Cell division control-related protein 1; Peanut-like protein 1",
        "protein_names_refseq": "cell division control related protein 1; peanut-like 1; platelet glycoprotein Ib beta chain; septin-5 isoform 2",
        "tax_id": 9606,
        "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)",
        "pathway": " (hsa:5413)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "11237011;11880646;12023038;14530399;15345747;15915442;18088087;18385322;18477386;19651622;19690332;20166139;20230923;23186163;28832583;29557506;30429286;31154438;31530632;31844290;31848261;32157095;32350084;32387766;33203136;33592498;33981976;34509645;35051231;35251023;9022087;9385360;9611266",
        "class_list": "",
        "function": "Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). May play a role in platelet secretion (By similarity)., [UniProtKB]; Filament-forming cytoskeletal GTPase., [UniProtKB, UniProtKB]; Presynaptic Vesicle Protein SEPTIN5 Regulates the Degradation of APP C-Terminal Fragments and the Levels of Abeta. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the septin gene family of nucleotide binding proteins, originally described in yeast as cell division cycle regulatory proteins. Septins are highly conserved in yeast, Drosophila, and mouse and appear to regulate cytoskeletal organization. Disruption of septin function disturbs cytokinesis and results in large multinucleate or polyploid cells. This gene is mapped to 22q11, the region frequently deleted in DiGeorge and velocardiofacial syndromes. A translocation involving the MLL gene and this gene has also been reported in patients with acute myeloid leukemia. Alternative splicing results in multiple transcript variants. The presence of a non-consensus polyA signal (AACAAT) in this gene also results in read-through transcription into the downstream neighboring gene (GP1BB; platelet glycoprotein Ib), whereby larger, non-coding transcripts are produced. [provided by RefSeq, Dec 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15251;Q96MY5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0042802 identical protein binding;GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0005940 septin ring;GO:0005886 plasma membrane;GO:0015630 microtubule cytoskeleton;GO:0008021 synaptic vesicle;GO:0031105 septin complex",
        "go_biological_process": "GO:0016080 synaptic vesicle targeting;GO:0030534 adult behavior;GO:0035176 social behavior;GO:0008104 intracellular protein localization;GO:0061640 cytoskeleton-dependent cytokinesis",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q99719-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7L5Y9-1",
        "uniprot_id": [
            {
                "id": "MAEA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7L5Y9",
                "type": "external"
            }
        ],
        "mass": 45287.0,
        "length": 396,
        "protein_name": "E3 ubiquitin-protein transferase MAEA",
        "gene_name": "MAEA",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein transferase MAEA isoform 4",
        "refseq_ac": [
            {
                "id": "NP_001284360",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284360",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAEA; EMP; HLC10; PIG5",
        "gene_names_refseq": "EMLP; EMP; GID9; HLC-10; MAEA; P44EMLP; PIG5",
        "protein_names_uniprotkb": "E3 ubiquitin-protein transferase MAEA; 2.3.2.27; Cell proliferation-inducing gene 5 protein; Erythroblast macrophage protein; HLC-10; Human lung cancer oncogene 10 protein; Macrophage erythroblast attacher; P44EMLP",
        "protein_names_refseq": "E3 ubiquitin-protein transferase MAEA isoform 4; E3 ubiquitin-protein transferase MAEA; GID complex subunit 9, FYV10 homolog; cell proliferation-inducing gene 5 protein; erythroblast macrophage protein; human lung cancer oncogene 10 protein; lung cancer-related protein 10",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10296);  (R-HSA-9861718)",
        "pathway_count": 2,
        "publication_count": 81,
        "publication_id_list": "11237011;16510120;17467196;18387606;20068231;21209280;22499340;23186163;23481700;24143168;24714562;24715725;25576301;25645385;25892735;26154972;26728094;26992070;27846572;27920218;28063628;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29911972;30315122;30410026;30484775;30779550;31154438;31217245;31530632;31735643;31844290;31937595;31998317;32157095;32357974;32387766;32488085;32897882;32938616;32983136;33141586;33298915;33462636;33537174;33592498;33633747;33691108;33912179;33936100;33968037;33981976;34087483;34185709;34211107;34405274;34509645;34932366;35051231;35318648;35580925;36010968;36215666;36241641;36284347;36882523;7757881;9763581",
        "class_list": "",
        "function": "Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). MAEA is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972). Plays a role in erythroblast enucleation during erythrocyte maturation and in the development of mature macrophages (By similarity). Mediates the attachment of erythroid cell to mature macrophages; this MAEA-mediated contact inhibits erythroid cell apoptosis (PubMed:9763581). Participates in erythroblastic island formation, which is the functional unit of definitive erythropoiesis. Associates with F-actin to regulate actin distribution in erythroblasts and macrophages (By similarity). May contribute to nuclear architecture and cells division events (Probable)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression., [RefSeq, PubMed]; RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells., [RefSeq, PubMed]; These results suggest that Emp undergoes dynamic rearrangements within the nuclear architecture that are correlated with cell division., [RefSeq, PubMed]; This gene encodes a protein that mediates the attachment of erythroblasts to macrophages. This attachment promotes terminal maturation and enucleation of erythroblasts, presumably by suppressing apoptosis. The encoded protein is an integral membrane protein with the N-terminus on the extracellular side and the C-terminus on the cytoplasmic side of the cell. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95285;Q5JB54;Q6ZRD6;Q9BQ11;Q9H9V6;Q9H9Z4;Q9NW84",
        "ec_number_list": [
            {
                "id": "1.1.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005819 spindle;GO:0005829 cytosol",
        "go_biological_process": "GO:0043249 erythrocyte maturation;GO:0007155 cell adhesion;GO:0051301 cell division;GO:0007346 regulation of mitotic cell cycle;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "Q7L5Y9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14D04-1",
        "uniprot_id": [
            {
                "id": "MELT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14D04",
                "type": "external"
            }
        ],
        "mass": 94745.0,
        "length": 833,
        "protein_name": "Ventricular zone-expressed PH domain-containing protein homolog 1",
        "gene_name": "VEPH1",
        "organism": "Human",
        "refseq_name": "ventricular zone-expressed PH domain-containing protein homolog 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001161383",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161383",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "VEPH1; KIAA1692; VEPH",
        "gene_names_refseq": "MELT; VEPH1; VEPH",
        "protein_names_uniprotkb": "Ventricular zone-expressed PH domain-containing protein homolog 1; Protein melted",
        "protein_names_refseq": "protein melted; ventricular zone expressed PH domain homolog 1; ventricular zone-expressed PH domain-containing protein homolog 1 isoform 2; ventricular zone-expressed PH domain-containing protein homolog 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79674)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;15388229;16054033;19913121;20237496;23481700;26039994;27600516;27869121;28411811;29557506;31614206;31844290;32157095;32342520;32488085;32610114;33592498;33968037;35051231;35580925;36828346;37244789",
        "class_list": "",
        "function": "A novel role of VEPH1 in regulating AoSMC phenotypic switching., [RefSeq, PubMed]; Dampened VEPH1 activates mTORC1 signaling by weakening the TSC1/TSC2 association in hepatocellular carcinoma., [RefSeq, PubMed]; Interacts with TGF-beta receptor type-1 (TGFBR1) and inhibits dissociation of activated SMAD2 from TGFBR1, impeding its nuclear accumulation and resulting in impaired TGF-beta signaling. May also affect FOXO, Hippo and Wnt signaling., [UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; The adaptor protein VEPH1 interacts with the kinase domain of ERBB2 and impacts EGF signaling in ovarian cancer cells., [RefSeq, PubMed]; VEPH1 acts to enhance Androgen Receptor (AR) activity in ovarian cancer cells by decreasing SMAD3 and pAKT levels, resulting in increased levels of AR protein., [RefSeq, PubMed]; VEPH1 suppresses the progression of gastric cancer by regulating the Hippo-YAP signalling pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DNL0;F5GZ91;Q2TAA9;Q3MIX2;Q6PEL3;Q86TL5;Q8TCR3;Q96SP7;Q9C0H1;Q9H9Q7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0010314 phosphatidylinositol-5-phosphate binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0009966 regulation of signal transduction;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0060392 negative regulation of SMAD protein signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q14D04-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H3L0-1",
        "uniprot_id": [
            {
                "id": "MMAD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H3L0",
                "type": "external"
            }
        ],
        "mass": 32940.0,
        "length": 296,
        "protein_name": "Cobalamin trafficking protein CblD",
        "gene_name": "MMADHC",
        "organism": "Human",
        "refseq_name": "cobalamin trafficking protein CblD",
        "refseq_ac": [
            {
                "id": "NP_056517",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056517",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MMADHC; C2orf25; CL25022; HSPC161; My011",
        "gene_names_refseq": "C2orf25; CL25022; HMAD; MACD; MAHCD; MMADHC; cblD",
        "protein_names_uniprotkb": "Cobalamin trafficking protein CblD; CblD; Methylmalonic aciduria and homocystinuria type D protein, mitochondrial",
        "protein_names_refseq": "cobalamin trafficking protein CblD; methylmalonic aciduria (cobalamin deficiency) cblD type, with homocystinuria; methylmalonic aciduria and homocystinuria type D protein, mitochondrial; protein C2orf25, mitochondrial",
        "tax_id": 9606,
        "disease": "methylmalonic aciduria and homocystinuria type cblD (Disease Ontology:DOID:0050716); homocystinuria-megaloblastic anemia cblD type (MONDO:MONDO:0700297); isolated methylmalonic aciduria cblD type (MONDO:MONDO:0700298)",
        "pathway": " (hsa:27249);  (R-HSA-3359473);  (R-HSA-9759218)",
        "pathway_count": 3,
        "publication_count": 88,
        "publication_id_list": "10.1101/2023.09.13.557529;10444342;10484769;10978155;11237011;12375236;12438653;12514191;15292234;15523652;15913339;16281286;16311595;17477549;17892308;18251506;18385497;18779575;19243433;19447654;19608861;19801555;19913121;20112406;20628086;20657474;21071249;21697092;22156578;22832074;23270877;23415655;24722857;25418920;25576301;2567699;26154972;26364851;26483544;26811146;26929215;26992070;27600516;27771510;27862975;28063628;28228285;28832583;28904123;28939051;29242379;29331515;29393594;29493099;29557506;29632046;29786170;30282455;30315122;30484775;31154438;31217245;31530632;31844290;32157095;32161166;32265295;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33691108;33797888;33912179;33936100;33968037;33981976;34171305;35051231;35580925;36215666;36241641;4390543;8968737",
        "class_list": "",
        "function": "Involved in cobalamin metabolism and trafficking (PubMed:18385497, PubMed:23415655, PubMed:24722857, PubMed:26364851). Plays a role in regulating the biosynthesis and the proportion of two coenzymes, methylcob(III)alamin (MeCbl) and 5'-deoxyadenosylcobalamin (AdoCbl) (PubMed:18385497, PubMed:23415655, PubMed:24722857). Promotes oxidation of cob(II)alamin bound to MMACHC (PubMed:26364851). The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR (methionine synthase) which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine (PubMed:27771510)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Mutations in a gene designated MMADHC (currently named C2orf25) are responsible for the cblD defect in vitamin B12 metabolism; various mutations are associated with each of the three biochemical phenotypes of the disorder, [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The study of genes involved in methylmalonic acidaemia with homocystinuria detected a homozygous mutation (c.748C>T) in the MMADHC gene (found in the DNA of both sisters), which generates a stop codon that results in a truncated protein, provoking the disease., [RefSeq, PubMed]; This gene encodes a mitochondrial protein that is involved in an early step of vitamin B12 metabolism. Vitamin B12 (cobalamin) is essential for normal development and survival in humans. Mutations in this gene cause methylmalonic aciduria and homocystinuria type cblD (MMADHC), a disorder of cobalamin metabolism that is characterized by decreased levels of the coenzymes adenosylcobalamin and methylcobalamin. Pseudogenes have been identified on chromosomes 11 and X.[provided by RefSeq, Nov 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 12,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R895;D3DP91;O95891",
        "ec_number_list": [],
        "go_molecular_function": "GO:0140104 molecular carrier activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0009235 cobalamin metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "Q9H3L0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6WCQ1-1",
        "uniprot_id": [
            {
                "id": "MPRIP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6WCQ1",
                "type": "external"
            }
        ],
        "mass": 116533.0,
        "length": 1025,
        "protein_name": "Myosin phosphatase Rho-interacting protein",
        "gene_name": "MPRIP",
        "organism": "Human",
        "refseq_name": "myosin phosphatase Rho-interacting protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_055949",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055949",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MPRIP; KIAA0864; MRIP; RHOIP3",
        "gene_names_refseq": "M-RIP; MPRIP; MRIP; RHOIP3; RIP3; p116Rip",
        "protein_names_uniprotkb": "Myosin phosphatase Rho-interacting protein; M-RIP; RIP3; Rho-interacting protein 3; p116Rip",
        "protein_names_refseq": "Rho interacting protein 3; myosin phosphatase Rho-interacting protein isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23164);  (R-HSA-6802952)",
        "pathway_count": 2,
        "publication_count": 85,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;14506264;15545284;15630448;16257966;17081983;18212344;18452278;18669648;18691976;18767875;18974108;19007248;19651622;19690332;19691289;20068231;20526349;21406692;21424530;22745804;23186163;23583981;24135138;24275569;24345920;24714562;24715725;25204415;25907612;26992070;27600516;27846572;27862975;27920218;28063628;28218747;28657654;28832583;28834231;28904123;29242379;29371260;29393594;29437277;29508533;29557506;29632046;29769354;29786170;30379171;30524438;31492838;31844290;32157095;32488085;32502341;32897882;32938616;32983136;33592498;33691108;33717175;33912179;33968037;33981976;34019948;34087483;34171305;34932366;35051231;35254053;35318648;35561310;35580925;36010968;36215666;36284347;36581221;36979361;37938771;38494770;38665916;40596516",
        "class_list": "",
        "function": "P116Rip is an important regulatory component that controls the RhoA signaling pathway, thus regulating MLCP activity and myosin phosphorylation in cells, [RefSeq, PubMed]; PIP2-Effector Protein MPRIP Regulates RNA Polymerase II Condensation and Transcription. Publication Status: Online-Only, [RefSeq, PubMed]; Targets myosin phosphatase to the actin cytoskeleton. Required for the regulation of the actin cytoskeleton by RhoA and ROCK1. Depletion leads to an increased number of stress fibers in smooth muscle cells through stabilization of actin fibers by phosphorylated myosin. Overexpression of MRIP as well as its F-actin-binding region leads to disassembly of stress fibers in neuronal cells., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; [circDDX17 targets miR-223-3p / RIP3 to regulate the proliferation and apoptosis of non-small cell lung cancer cells]., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 38,
        "reported_mutagensis": 0,
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        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3KQZ5;Q5FB94;Q6DHW2;Q7Z5Y2;Q8N390;Q96G40",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0051015 actin filament binding;GO:0045296 cadherin binding;GO:0003779 actin binding",
        "go_cellular_component": "GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "Q6WCQ1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P20645-1",
        "uniprot_id": [
            {
                "id": "MPRD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P20645",
                "type": "external"
            }
        ],
        "mass": 30993.0,
        "length": 277,
        "protein_name": "Cation-dependent mannose-6-phosphate receptor",
        "gene_name": "M6PR",
        "organism": "Human",
        "refseq_name": "cation-dependent mannose-6-phosphate receptor isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_002346",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002346",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "M6PR; MPR46; MPRD",
        "gene_names_refseq": "CD-M6PR; CD-MPR; M6PR; MPR 46; MPR-46; MPR46; SMPR",
        "protein_names_uniprotkb": "Cation-dependent mannose-6-phosphate receptor; 46 kDa mannose 6-phosphate receptor; CD Man-6-P receptor; CD-MPR; MPR 46",
        "protein_names_refseq": "46-kDa mannose 6-phosphate receptor; CD Man-6-P receptor; Mr 46,000 Man6PR; cation-dependent mannose-6-phosphate receptor isoform 1 precursor; cation-dependent mannose-6-phosphate receptor; small mannose 6-phosphate receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4074);  (R-HSA-432720);  (R-HSA-6811440);  (R-HSA-8856825);  (R-HSA-8856828);  (R-HSA-9840310)",
        "pathway_count": 6,
        "publication_count": 467,
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        "class_list": "glycogene",
        "function": "Association between genetic variants in oxidative stress-related genes and osteoporotic bone fracture. The Hortega follow-up study., [RefSeq, PubMed]; Gimap5 promoted RSV degradation through interaction with M6PR., [RefSeq, PubMed]; Loss of the batten disease protein CLN3 leads to mis-trafficking of M6PR and defective autophagic-lysosomal reformation. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the P-type lectin family. P-type lectins play a critical role in lysosome function through the specific transport of mannose-6-phosphate-containing acid hydrolases from the Golgi complex to lysosomes. The encoded protein functions as a homodimer and requires divalent cations for ligand binding. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. A pseudogene of this gene is located on the long arm of chromosome X. [provided by RefSeq, May 2011]., [RefSeq]; Transport of phosphorylated lysosomal enzymes from the Golgi complex and the cell surface to lysosomes. Lysosomal enzymes bearing phosphomannosyl residues bind specifically to mannose-6-phosphate receptors in the Golgi apparatus and the resulting receptor-ligand complex is transported to an acidic prelyosomal compartment where the low pH mediates the dissociation of the complex., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 275,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 82,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K528;D3DUV5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0019904 protein domain specific binding;GO:1905394 retromer complex binding;GO:0140318 protein transporter activity",
        "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0032588 trans-Golgi network membrane;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0008333 endosome to lysosome transport;GO:0006898 receptor-mediated endocytosis;GO:0006622 protein targeting to lysosome;GO:0046479 glycosphingolipid catabolic process;GO:0007041 lysosomal transport",
        "synthesized_glycan_count": 0,
        "hit_score": 55.7,
        "record_id": "P20645-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000001.100.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NXB0-1",
        "uniprot_id": [
            {
                "id": "MKS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NXB0",
                "type": "external"
            }
        ],
        "mass": 64528.0,
        "length": 559,
        "protein_name": "Tectonic-like complex member MKS1",
        "gene_name": "MKS1",
        "organism": "Human",
        "refseq_name": "tectonic-like complex member MKS1 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001308197",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308197",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MKS1",
        "gene_names_refseq": "BBS13; JBTS28; MES; MKS1; MKS; POC12",
        "protein_names_uniprotkb": "Tectonic-like complex member MKS1; Meckel syndrome type 1 protein",
        "protein_names_refseq": "POC12 centriolar protein homolog; meckel syndrome type 1 protein; tectonic-like complex member MKS1 isoform 3; tectonic-like complex member MKS1",
        "tax_id": 9606,
        "disease": "atrioventricular septal defect (Disease Ontology:DOID:0050651); Meckel syndrome (Disease Ontology:DOID:0050778); ciliopathy (Disease Ontology:DOID:0060340); Meckel syndrome 1 (Disease Ontology:DOID:0070115); Bardet-Biedl syndrome 13 (Disease Ontology:DOID:0110135); Joubert syndrome 28 (Disease Ontology:DOID:0110997); Bardet-Biedl syndrome (Disease Ontology:DOID:1935); tetralogy of Fallot (Disease Ontology:DOID:6419)",
        "pathway": " (hsa:54903);  (R-HSA-5610787);  (R-HSA-5620912)",
        "pathway_count": 3,
        "publication_count": 165,
        "publication_id_list": "10966113;11237011;11375483;12192414;12435627;14603322;15087129;15930098;16061793;16136078;16229832;16254602;16311594;16339192;16357211;16396903;16415886;16493421;16707575;17027958;17185389;17200122;17442700;17553904;17574030;17641202;17646400;17719545;17762891;17960137;18037885;18327255;18327258;18455992;18694559;18801063;18832070;19000668;19004860;19081074;19196978;19208769;19223390;19286674;19365551;19466712;19515853;19549984;19592253;19666503;19767740;19776033;19877275;19906846;19940019;19948480;19996169;20067783;20154143;20207148;20230748;20308558;20395968;20399632;20412786;20460306;20558667;20844016;20889716;20956384;2105456;21209331;21273506;21422230;21548880;21565611;21620453;21695114;21725307;21792235;21801010;22007132;22121117;22179047;22231273;22391300;22433857;22653444;23141531;23141541;23209152;23253480;23332756;23348840;23400999;23530209;23719536;23747070;23769972;23789104;24053599;24089205;24231678;24302888;24339784;24366607;24469809;24714562;24845016;24863049;24886560;24917297;24925320;24952464;24982133;25047611;25313408;25418920;25576301;25880248;25892735;26154972;26490104;26595381;26728094;26992070;27377014;27600516;27846572;27920218;28228285;28514659;28832583;28834231;29242379;29393594;29557506;29632046;29769354;30429286;31154438;31217245;31844290;32157095;32357974;32502341;32726168;32897882;32938616;32983136;33392160;33592498;33717175;33912179;33981976;34171305;34561969;34932366;35051231;35580925;36010968;36241641;36581221;37938771;39894887",
        "class_list": "",
        "function": "Component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Involved in centrosome migration to the apical cell surface during early ciliogenesis. Required for ciliary structure and function, including a role in regulating length and appropriate number through modulating centrosome duplication. Required for cell branching morphology., [UniProtKB, PubMed, PubMed, PubMed]; Formation of the B9-domain protein complex MKS1-B9D2-B9D1 is essential as a diffusion barrier for ciliary membrane proteins., [RefSeq, PubMed]; Identification of a gene, MKS1,(Meckel syndrome) mutated in MKS families linked to 17q., [RefSeq, PubMed]; The Meckel-Gruber Syndrome proteins MKS1 and meckelin interact and are required for primary cilium formation., [RefSeq, PubMed]; The protein encoded by this gene localizes to the basal body and is required for formation of the primary cilium in ciliated epithelial cells. Mutations in this gene result in Meckel syndrome type 1 and in Bardet-Biedl syndrome type 13. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7WNX4;F5H885;Q284T0;Q96G13",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0016020 membrane;GO:0005814 centriole",
        "go_biological_process": "GO:0060271 cilium assembly;GO:1904491 protein localization to ciliary transition zone;GO:0048754 branching morphogenesis of an epithelial tube;GO:0030030 cell projection organization",
        "synthesized_glycan_count": 0,
        "hit_score": 16.8,
        "record_id": "Q9NXB0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99542-1",
        "uniprot_id": [
            {
                "id": "MMP19_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99542",
                "type": "external"
            }
        ],
        "mass": 57357.0,
        "length": 508,
        "protein_name": "Matrix metalloproteinase-19",
        "gene_name": "MMP19",
        "organism": "Human",
        "refseq_name": "matrix metalloproteinase-19 isoform 3 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_001259030",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001259030",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MMP19; MMP18; RASI",
        "gene_names_refseq": "CODA; MMP18; MMP19; RASI-1",
        "protein_names_uniprotkb": "Matrix metalloproteinase-19; 3.4.24.-; MMP-18; MMP-19; Matrix metalloproteinase RASI; Matrix metalloproteinase-18",
        "protein_names_refseq": "matrix metalloproteinase RASI; matrix metalloproteinase-18; matrix metalloproteinase-19 isoform 3 preproprotein; matrix metalloproteinase-19; matrix metalloproteinase-beta19",
        "tax_id": 9606,
        "disease": "relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); familial cavitary optic disk anomaly (MONDO:MONDO:0012687)",
        "pathway": " (hsa:4327);  (R-HSA-1442490);  (R-HSA-1474228)",
        "pathway_count": 3,
        "publication_count": 106,
        "publication_id_list": "10049780;10229672;10386589;10551873;10706100;10809722;10922468;10986281;11013208;11119712;11237011;11375993;11577169;11872628;11927537;12579531;12727852;12843408;14973287;15005656;15234972;15257288;15591058;15950618;15958533;16133547;1649600;16631740;16825197;16825321;1698775;1704217;1707285;17088321;17332331;17354228;17608959;18434311;18622425;18658137;19010778;19571574;19657146;19714641;2005102;20142769;21030783;21297635;21441952;21593211;21670566;2169335;21784848;21864727;21935455;22159414;22241472;22382088;2253219;23035980;23845380;25171405;2537292;2548603;2551898;25576301;25581579;2834383;2845110;29557506;3038863;30459171;31154438;32157095;3223920;32938616;32983136;34932366;35051231;35352707;35580925;36915092;37971547;6258630;6270089;6694361;7075587;7547873;7890717;8226919;8463259;8576151;8626565;8920930;8920941;8999957;9020145;9065415;9092507;9115292;9148753;9232430;9461298;9562866;9651395;9852107",
        "class_list": "",
        "function": "Endopeptidase that degrades various components of the extracellular matrix, such as aggrecan and cartilage oligomeric matrix protein (comp), during development, haemostasis and pathological conditions (arthritic disease). May also play a role in neovascularization or angiogenesis. Hydrolyzes collagen type IV, laminin, nidogen, nascin-C isoform, fibronectin, and type I gelatin., [UniProtKB, PubMed, PubMed]; Endothelial cell-derived MMP19 promotes pulmonary fibrosis by inducing E(nd)MT and monocyte infiltration. Publication Status: Online-Only, [RefSeq, PubMed]; MMP19 Variants in Familial and Sporadic Idiopathic Pulmonary Fibrosis., [RefSeq, PubMed]; Potential novel markers in IBD and CRC diagnostics. Are MMP-19 and RAGE promising candidates?, [RefSeq, PubMed]; This gene encodes a member of a family of proteins that are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded protein is secreted as an inactive proprotein, which is activated upon cleavage by extracellular proteases. Alternative splicing results in multiple transcript variants for this gene. [provided by RefSeq, Jan 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E030;O15278;O95606;Q99580",
        "ec_number_list": [
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "3.4.24.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7",
                "type": "external"
            },
            {
                "id": "3.4.24.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24",
                "type": "external"
            },
            {
                "id": "3.4.24.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17",
                "type": "external"
            },
            {
                "id": "3.4.24.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23",
                "type": "external"
            },
            {
                "id": "3.4.24.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22",
                "type": "external"
            },
            {
                "id": "3.4.24.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.19",
                "type": "external"
            },
            {
                "id": "3.4.24.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35",
                "type": "external"
            },
            {
                "id": "3.4.24.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34",
                "type": "external"
            },
            {
                "id": "3.4.22.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27",
                "type": "external"
            },
            {
                "id": "3.4.24.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0004252 serine-type endopeptidase activity;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0022617 extracellular matrix disassembly;GO:0030154 cell differentiation;GO:0030198 extracellular matrix organization",
        "synthesized_glycan_count": 0,
        "hit_score": 10.9,
        "record_id": "Q99542-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WWC4-1",
        "uniprot_id": [
            {
                "id": "MAIP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WWC4",
                "type": "external"
            }
        ],
        "mass": 32545.0,
        "length": 291,
        "protein_name": "m-AAA protease-interacting protein 1, mitochondrial",
        "gene_name": "MAIP1",
        "organism": "Human",
        "refseq_name": "m-AAA protease-interacting protein 1, mitochondrial isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_078796",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078796",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAIP1; C2orf47",
        "gene_names_refseq": "C2orf47; MAIP1",
        "protein_names_uniprotkb": "m-AAA protease-interacting protein 1, mitochondrial; Matrix AAA peptidase-interacting protein 1",
        "protein_names_refseq": "m-AAA protease-interacting protein 1, mitochondrial isoform 1 precursor; m-AAA protease-interacting protein 1, mitochondrial",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79568);  (R-HSA-8949664)",
        "pathway_count": 2,
        "publication_count": 24,
        "publication_id_list": "11237011;20068231;20877624;27499296;27642048;27737933;27846572;28218747;28228285;29557506;29632046;31217245;31844290;32157095;32938616;32983136;33141586;33298915;33592498;33936100;34932366;35051231;36010968;37355744",
        "class_list": "",
        "function": "MiR-27b targets MAIP1 to mediate lipid accumulation in cultured human and mouse hepatic cells. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Promotes sorting of SMDT1/EMRE in mitochondria by ensuring its maturation (PubMed:27642048). Interacts with the transit peptide region of SMDT1/EMRE precursor protein in the mitochondrial matrix, leading to protect it against protein degradation by YME1L1, thereby ensuring SMDT1/EMRE maturation by the mitochondrial processing peptidase (PMPCA and PMPCB) (PubMed:27642048)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q658V9;Q9H671",
        "ec_number_list": [],
        "go_molecular_function": "GO:0043022 ribosome binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis;GO:0051204 protein insertion into mitochondrial membrane;GO:0032979 protein insertion into mitochondrial inner membrane from matrix",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q8WWC4-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96N66-1",
        "uniprot_id": [
            {
                "id": "MBOA7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96N66",
                "type": "external"
            }
        ],
        "mass": 52765.0,
        "length": 472,
        "protein_name": "Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7",
        "gene_name": "MBOAT7",
        "organism": "Human",
        "refseq_name": "membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001139528",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139528",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MBOAT7; BB1; LENG4; OACT7",
        "gene_names_refseq": "BB1; LENG4; LPIAT1; LPIAT; LPLAT11; LPLAT; LRC4; MBOA7; MBOAT7; MRT57; OACT7; hMBOA-7",
        "protein_names_uniprotkb": "Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7; 1-acylglycerophosphatidylinositol O-acyltransferase; 2.3.1.-; Bladder and breast carcinoma-overexpressed gene 1 protein; LPIAT; LPLAT 7; Leukocyte receptor cluster member 4; Lyso-PI acyltransferase; Lysophosphatidylinositol acyltransferase; Lysophospholipid acyltransferase 7; Membrane-bound O-acyltransferase domain-containing protein 7; O-acyltransferase domain-containing protein 7; h-mboa-7",
        "protein_names_refseq": "1-acylglycerophosphatidylinositol O-acyltransferase; LPLAT 7; bladder and breast carcinoma-overexpressed gene 1 protein; h-mboa-7; leukocyte receptor cluster (LRC) member 4; lyso-PI acyltransferase; lysophosphatidylinositol acyltransferase 1; lysophosphatidylinositol acyltransferase; lysophospholipid acyltransferase 11; lysophospholipid acyltransferase 7; malignant cell expression-enhanced gene/tumor progression-enhanced; membrane bound O-acyltransferase domain containing 7; membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7 isoform 2",
        "tax_id": 9606,
        "disease": "autosomal recessive intellectual developmental disorder 57 (Disease Ontology:DOID:0081219); hydrocephalus (Disease Ontology:DOID:10908)",
        "pathway": " (hsa:79143);  (R-HSA-1482922)",
        "pathway_count": 2,
        "publication_count": 86,
        "publication_id_list": "10455175;10681567;10941842;11031251;11112443;11237011;11830583;12161451;12359733;12522102;18094042;18614531;18669648;18772128;19019078;20068231;20705608;22645359;23510452;24715725;25576301;25892735;26154972;26992070;27543614;27600516;27616480;28218747;28228285;28832583;29242379;2925608;29331515;29393594;29437277;29493099;29557506;29769354;30315122;30410026;30429286;30524438;30959108;31217245;31575892;31611695;31844290;32157095;32253259;32387766;32488085;32502341;32938616;33141586;33392160;33592498;33633747;33936100;33968037;33981976;34087483;34171305;34357683;34405274;34509645;34561969;34725712;35051231;35083852;35318648;35561310;35580925;36010968;36215666;36241641;37691145;37938771;38088234;38183501;38648183;38665916;38682204;7060561;8300559;8702217;9188469",
        "class_list": "",
        "function": "A Cell Specific Effect of MBOAT7 MAFLD-risk Variant on Immune Cells., [RefSeq, PubMed]; Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA to a lysophosphatidylinositol (1-acylglycerophosphatidylinositol or LPI) leading to the production of a phosphatidylinositol (1,2-diacyl-sn-glycero-3-phosphoinositol or PI) and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18094042, PubMed:18772128). Prefers arachidonoyl-CoA as the acyl donor, thus contributing to the regulation of free levels arachidonic acid in cell (PubMed:18094042, PubMed:18772128). In liver, participates in the regulation of triglyceride metabolism through the phosphatidylinositol acyl-chain remodeling regulation (PubMed:32253259)., [UniProtKB, PubMed, PubMed, PubMed]; Describes the cloning of human MBOAT7, [RefSeq, PubMed]; Exome sequencing identifies homozygous variants in MBOAT7 associated with neurodevelopmental disorder., [RefSeq, PubMed]; LENG4 is located in the leukocyte receptor cluster on chromosome 19. Erratum:[Immunogenetics 2001;52(3-4):308], [RefSeq, PubMed]; MBOAT5 and MBOAT7 in arachidonate recycling, thus regulating free arachidonic acid levels and leukotriene synthesis in neutrophils, [RefSeq, PubMed]; MBOAT7 expression is associated with disease progression in COVID-19 patients. Publication Status: Online-Only, [RefSeq, PubMed]; MMD collaborates with ACSL4 and MBOAT7 to promote polyunsaturated phosphatidylinositol remodeling and susceptibility to ferroptosis., [RefSeq, PubMed]; Membrane-bound O-acyltransferase 7 (MBOAT7) shapes lysosomal lipid homeostasis and function to control alcohol-associated liver injury. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A9C4B6;B0V3I5;B4DQ87;Q05DF0;Q7L5N2;Q99908;Q9BPV2;Q9BRE9",
        "ec_number_list": [
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.n6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6",
                "type": "external"
            },
            {
                "id": "2.3.1.n7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity;GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0071617 lysophospholipid acyltransferase activity;GO:0008374 O-acyltransferase activity;GO:0016746 acyltransferase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0044233 mitochondria-associated endoplasmic reticulum membrane contact site",
        "go_biological_process": "GO:0036151 phosphatidylcholine acyl-chain remodeling;GO:0006661 phosphatidylinositol biosynthetic process;GO:0021819 layer formation in cerebral cortex;GO:0090207 regulation of triglyceride metabolic process;GO:0030258 lipid modification",
        "synthesized_glycan_count": 0,
        "hit_score": 8.9,
        "record_id": "Q96N66-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NZ43-1",
        "uniprot_id": [
            {
                "id": "USE1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZ43",
                "type": "external"
            }
        ],
        "mass": 29371.0,
        "length": 259,
        "protein_name": "Vesicle transport protein USE1",
        "gene_name": "USE1",
        "organism": "Human",
        "refseq_name": "vesicle transport protein USE1",
        "refseq_ac": [
            {
                "id": "NP_060937",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060937",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "USE1; MDS032; USE1L",
        "gene_names_refseq": "D12; MDS032; P31; SLT1; USE1",
        "protein_names_uniprotkb": "Vesicle transport protein USE1; Putative MAPK-activating protein PM26; USE1-like protein; p31",
        "protein_names_refseq": "Q-SNARE; SNARE-like tail-anchored protein 1 homolog; USE1-like protein; protein p31; putative MAPK activating protein PM26; unconventional SNARE in the ER 1 homolog; vesicle transport protein USE1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55850);  (R-HSA-6811434)",
        "pathway_count": 2,
        "publication_count": 119,
        "publication_id_list": "10.1101/2023.09.13.557529;10052452;10318838;10445031;10559959;10761932;10921873;11172815;11237011;11493604;11689559;11703931;11726511;11739780;11748249;12047556;12070132;12761501;14504276;14654841;15029241;15037235;15272311;15616190;15632110;15813748;16030262;1631136;16571679;16633337;1680566;16912714;16926190;16940185;17113389;17253781;17360540;17429068;17451557;17760859;17927562;17956946;18182008;18287528;18524849;18809720;1898986;19015319;19109418;19151722;19164740;19369418;1957170;19631211;19758564;20005805;20068231;20136777;20357002;20427317;20462495;20534429;20637885;21219331;21550981;21689688;21844168;22013193;22094269;22304919;23396477;25364732;25436559;25492864;25576301;25645385;26992070;27600516;28218747;28228285;28904123;29393594;29437277;29557506;29632711;30315122;31154438;31217245;31844290;32350084;32387766;32488085;32502341;32938616;33298915;33691108;33936100;33968037;34509645;35051231;35251023;35580925;36241641;37604583;7844144;8001155;8128252;8132710;8221884;8253837;8505331;8620540;9114004;9177194;9244307;9288971;9405360;9751720;9990005",
        "class_list": "",
        "function": "Results together suggest that NAG links between p31 and ZW10-RINT-1 and is involved in Golgi-to-ER transport., [RefSeq, PubMed]; SNARE that may be involved in targeting and fusion of Golgi-derived retrograde transport vesicles with the ER., [UniProtKB, PubMed]; Tumor necrosis factor mediates USE1-independent FAT10ylation under inflammatory conditions. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NCK1;Q9BRT4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005484 SNAP receptor activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:0030137 COPI-coated vesicle;GO:0031201 SNARE complex",
        "go_biological_process": "GO:0015031 protein transport;GO:0032940 secretion by cell;GO:0006890 retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum;GO:0030163 protein catabolic process;GO:0007041 lysosomal transport",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "Q9NZ43-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96EY5-1",
        "uniprot_id": [
            {
                "id": "MB12A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96EY5",
                "type": "external"
            }
        ],
        "mass": 28783.0,
        "length": 273,
        "protein_name": "Multivesicular body subunit 12A",
        "gene_name": "MVB12A",
        "organism": "Human",
        "refseq_name": "multivesicular body subunit 12A isoform 1",
        "refseq_ac": [
            {
                "id": "NP_612410",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_612410",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MVB12A; CFBP; FAM125A",
        "gene_names_refseq": "CFBP; FAM125A; MVB12A",
        "protein_names_uniprotkb": "Multivesicular body subunit 12A; CIN85/CD2AP family-binding protein; ESCRT-I complex subunit MVB12A; Protein FAM125A",
        "protein_names_refseq": "CIN85/CD2AP family binding protein; ESCRT-I complex subunit MVB12A; family with sequence similarity 125, member A; multivesicular body subunit 12A isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:93343);  (R-HSA-162588);  (R-HSA-174490);  (R-HSA-917729);  (R-HSA-9610379);  (R-HSA-9615710)",
        "pathway_count": 6,
        "publication_count": 75,
        "publication_id_list": "11112487;11237011;11527981;11563910;12663786;14624836;15075231;15218037;15473846;15509564;15613341;16371348;16775314;16895919;16964243;16973552;17853893;18005716;18669648;19527882;19640981;19690332;20068231;20654576;21238931;21289126;21757351;2204156;22762019;23186163;23266279;23305486;24715725;25645385;25961502;26154972;26992070;27397612;27600516;2799391;28218747;28832583;28834231;28904123;29242379;29331515;29493099;29557506;30429286;31217245;31611695;31844290;31848261;32157095;32350084;32387766;32424346;32488085;32938616;32983136;33141586;33298915;33392160;33592498;33912179;33936100;33968037;33981976;34171305;35051231;35251023;35580925;37938771;9506952;9525617",
        "class_list": "",
        "function": "A helical assembly of human ESCRT-I scaffolds reverse-topology membrane scission., [RefSeq, PubMed]; CFBP is a novel tyrosine-phosphorylated protein that might function as a regulator of CIN85/CD2AP, [RefSeq, PubMed]; Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in the ligand-mediated internalization and down-regulation of EGF receptor., [UniProtKB, PubMed, UniProtKB, UniProtKB]; These results suggest that the expression of MVB12B may be normally suppressed through the ubiquitin-proteasome pathway that simultaneously regulates the fate of MVB12A and the functions of ESCRT-I. Erratum:[Biochem Biophys Res Commun. 2011 Mar 4;406(1):158-9], [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96I18",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0008289 lipid binding;GO:0043130 ubiquitin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0031902 late endosome membrane",
        "go_biological_process": "GO:0036258 multivesicular body assembly;GO:0039702 viral budding via host ESCRT complex;GO:0043328 protein transport to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway;GO:0016236 macroautophagy;GO:0032801 receptor catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.6,
        "record_id": "Q96EY5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q2M296-1",
        "uniprot_id": [
            {
                "id": "MTHSD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q2M296",
                "type": "external"
            }
        ],
        "mass": 42173.0,
        "length": 383,
        "protein_name": "Methenyltetrahydrofolate synthase domain-containing protein",
        "gene_name": "MTHFSD",
        "organism": "Human",
        "refseq_name": "methenyltetrahydrofolate synthase domain-containing protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001152849",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001152849",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MTHFSD",
        "gene_names_refseq": "MTHFSD",
        "protein_names_uniprotkb": "Methenyltetrahydrofolate synthase domain-containing protein",
        "protein_names_refseq": "methenyltetrahydrofolate synthase domain-containing protein isoform 1; methenyltetrahydrofolate synthase domain-containing protein; methenyltetrahydrofolate synthetase domain-containing protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64779)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;19913121;20628086;26992070;28218747;28904123;29437277;29493099;30315122;30410026;31154438;31844290;31848261;32157095;32938616;32983136;33298915;33912179;33936100;33968037;34171305;35051231;39894887",
        "class_list": "",
        "function": "Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "secondary_ac_list": "A8MQ77;B7ZLC0;B7ZLC2;D3DUM9;E9PAM1;Q9H878;Q9H954",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
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        "hit_score": 2.6,
        "record_id": "Q2M296-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P50219-1",
        "uniprot_id": [
            {
                "id": "MNX1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P50219",
                "type": "external"
            }
        ],
        "mass": 40569.0,
        "length": 401,
        "protein_name": "Motor neuron and pancreas homeobox protein 1",
        "gene_name": "MNX1",
        "organism": "Human",
        "refseq_name": "motor neuron and pancreas homeobox protein 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001158727",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001158727",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MNX1; HLXB9",
        "gene_names_refseq": "HB9; HLXB9; HOXHB9; MNX1; SCRA1",
        "protein_names_uniprotkb": "Motor neuron and pancreas homeobox protein 1; Homeobox protein HB9",
        "protein_names_refseq": "homeobox HB9; homeobox protein HB9; motor neuron and pancreas homeobox protein 1 isoform 2; motor neuron and pancreas homeobox protein 1",
        "tax_id": 9606,
        "disease": "Currarino syndrome (Disease Ontology:DOID:0111546)",
        "pathway": " (hsa:3110)",
        "pathway_count": 1,
        "publication_count": 31,
        "publication_id_list": "10329000;10631160;10749657;11237011;18669648;19413330;19853743;22820079;23186163;24425879;25576301;25645385;28063628;28218747;28832583;29242379;29632046;31217245;31844290;32928873;32938616;33650152;33912179;34953915;35051231;35580925;35583991;36429006;37317878;38253038;7914194",
        "class_list": "",
        "function": "Aberrant MNX1 expression associated with t(7;12)(q36;p13) pediatric acute myeloid leukemia induces the disease through altering histone methylation. Publication Status: Online-Only, [RefSeq, PubMed]; An induced pluripotent stem cell t(7;12)(q36;p13) acute myeloid leukemia model shows high expression of MNX1 and a block in differentiation of the erythroid and megakaryocytic lineages., [RefSeq, PubMed]; MNX1-HNF1B Axis Is Indispensable for Intraductal Papillary Mucinous Neoplasm Lineages., [RefSeq, PubMed]; Pan-Cancer Analysis Identifies MNX1 and Associated Antisense Transcripts as Biomarkers for Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Presacral neuroendocrine tumors associated with the Currarino syndrome. Erratum:[Am J Med Genet A. 2022 Apr;188(4):1340. doi: 10.1002/ajmg.a.62618. PMID: 34964246], [RefSeq, PubMed]; This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]., [RefSeq]; Transcription factor (By similarity). Recognizes and binds to the regulatory elements of target genes, such as visual system homeobox CHX10, negatively modulating transcription (By similarity). Plays a role in establishing motor neuron identity, in concert with LIM domain transcription factor LMO4 (By similarity). Involved in negatively modulating transcription of interneuron genes in motor neurons, acting, at least in part, by blocking regulatory sequence interactions of the ISL1-LHX3 complex (By similarity). Involved in pancreas development and function; may play a role in pancreatic cell fate specification (By similarity)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 2,
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        "total_reported_o_glycosites": 2,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "F5H401;Q9Y648",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0021520 spinal cord motor neuron cell fate specification;GO:0006351 DNA-templated transcription;GO:0048812 neuron projection morphogenesis;GO:0007417 central nervous system development;GO:0031018 endocrine pancreas development",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "P50219-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q71UM5-1",
        "uniprot_id": [
            {
                "id": "RS27L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q71UM5",
                "type": "external"
            }
        ],
        "mass": 9477.0,
        "length": 84,
        "protein_name": "Ribosomal protein eS27-like",
        "gene_name": "RPS27L",
        "organism": "Human",
        "refseq_name": "ribosomal protein eS27-like",
        "refseq_ac": [
            {
                "id": "NP_057004",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057004",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RPS27L",
        "gene_names_refseq": "RPS27L",
        "protein_names_uniprotkb": "Ribosomal protein eS27-like; 40S ribosomal protein S27-like; Small ribosomal subunit protein eS27-like",
        "protein_names_refseq": "40S ribosomal protein S27-like; ribosomal protein eS27-like; small ribosomal subunit protein eS27-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51065);  (R-HSA-156827);  (R-HSA-156902);  (R-HSA-1799339);  (R-HSA-192823);  (R-HSA-2408557);  (R-HSA-6791226);  (R-HSA-72649);  (R-HSA-72689);  (R-HSA-72695);  (R-HSA-72702);  (R-HSA-72706);  (R-HSA-72764);  (R-HSA-9010553);  (R-HSA-9633012);  (R-HSA-9735869);  (R-HSA-9754678);  (R-HSA-975956);  (R-HSA-975957);  (R-HSA-9954714);  (R-HSA-9954716)",
        "pathway_count": 21,
        "publication_count": 259,
        "publication_id_list": "10358005;10364207;10659855;1095581;10970870;10982836;11018020;11018027;1104615;11237011;11265756;11331269;11532962;11544179;11546874;11551508;11677247;11691921;11726970;11922599;11964406;12068309;12150911;12417715;12493757;12554878;12588972;12718880;12832468;12853463;1400365;14527413;14567916;14630918;14636577;14742663;14973490;15034551;15317934;15385533;15534230;15546618;15721257;15775988;15781252;15821744;16026328;16037817;16043514;16186820;16209946;16284618;16452507;16469117;16601204;16622410;16630668;16738141;16912115;16989641;17053788;17142313;17189298;17267404;17352659;17353269;17363904;17412707;17726049;17803942;17893241;18065403;18066079;18166647;18230761;18256688;18285520;18423202;18438418;18447580;18447585;18448518;18455985;18524595;18539146;1856230;1861871;18657639;18767875;18974281;18991276;19060897;19106111;19150429;19332556;19359157;19417104;19478851;19503078;19556969;19564402;19608919;19706539;19801658;19838190;19859661;19909264;20023408;20038530;20056613;2006156;20361218;20444697;20479275;20531386;20691628;20798176;20805244;20817927;20819938;20930030;21029861;21036871;21063389;21097556;21145460;21419344;22072790;22174690;22190735;22195017;22424782;22855488;22916032;23035226;23085078;23217742;23234702;23269699;23439679;23481700;23482395;23746841;23826192;2388630;24424021;24550520;24714562;25132172;25242263;25418920;25432065;25525153;25576301;25969445;26237581;26375851;27526673;27600516;27846572;27920218;28063628;28065601;28132843;28218747;28228285;28514659;28649982;28685749;28832583;28834231;28904123;29242379;29393594;29413899;29437277;29508533;29557506;29632046;29632711;29786170;30192525;30293783;30315122;30410026;30425236;30429286;30484775;30804176;31154438;31217245;31844290;31998317;32099016;32157095;32161166;32350084;32387766;32502341;32579943;32680882;32779270;32897882;32908316;32938616;32983136;32995776;32995777;33051438;33080218;33141586;33188728;33214551;33268501;33298915;33392160;33479166;33592498;33691108;33717175;33936100;33968037;34087483;34171305;34211107;34315815;34373319;34624207;35051231;35561310;35580925;36010968;36241641;36302773;36610391;38665916;39395807;429297;592398;592399;641056;6568109;6853548;6901506;7000367;7990965;8336711;8407925;8890909;8943342;9045610;9211906;9431993;9482744;9631292;9637248;9712840;9732867;9857202",
        "class_list": "",
        "function": "Elevated RPS27L may improve the prognoses of certain colorectal cancer patients by enhancing the DNA repair capacity of their colonic cells. Publication Status: Online-Only, [RefSeq, PubMed]; Inactivation of ribosomal protein S27-like impairs DNA interstrand cross-link repair by destabilization of FANCD2 and FANCI. Publication Status: Online-Only, [RefSeq, PubMed]; Neddylation modification of ribosomal protein RPS27L or RPS27 by MDM2 or NEDP1 regulates cancer cell survival., [RefSeq, PubMed]; The study suggests that RPS27L reduction might play a promoting role during breast tumorigenesis by autophagy induction via the beta-TrCP-DEPTOR-mTORC1 axis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein sharing 96% amino acid similarity with ribosomal protein S27, which suggests the encoded protein may be a component of the 40S ribosomal subunit. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q9BTJ1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0008494 translation activator activity;GO:0003735 structural constituent of ribosome",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0022627 cytosolic small ribosomal subunit",
        "go_biological_process": "GO:0042771 intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator;GO:0006412 translation;GO:0045727 positive regulation of translation;GO:0030330 DNA damage response, signal transduction by p53 class mediator;GO:0031571 mitotic G1 DNA damage checkpoint signaling",
        "synthesized_glycan_count": 0,
        "hit_score": 26.2,
        "record_id": "Q71UM5-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NQ76-1",
        "uniprot_id": [
            {
                "id": "MEPE_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NQ76",
                "type": "external"
            }
        ],
        "mass": 58419.0,
        "length": 525,
        "protein_name": "Matrix extracellular phosphoglycoprotein",
        "gene_name": "MEPE",
        "organism": "Human",
        "refseq_name": "matrix extracellular phosphoglycoprotein isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001171623",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171623",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MEPE",
        "gene_names_refseq": "MEPE; OF45",
        "protein_names_uniprotkb": "Matrix extracellular phosphoglycoprotein; OF45; Osteoblast/osteocyte factor 45; Osteoregulin",
        "protein_names_refseq": "matrix extracellular phosphoglycoprotein isoform a precursor; matrix, extracellular phosphoglycoprotein with ASARM motif (bone); osteoblast/osteocyte factor 45; osteoregulin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56955);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 3,
        "publication_count": 87,
        "publication_id_list": "10026136;10077652;10218588;10512690;10614670;10681634;10810289;10898936;10912521;10945470;10951195;10990447;11158056;11237011;11250653;11264294;11316783;11414762;11522292;11606061;11739083;11751371;11788658;12220505;12241545;12379487;12421822;12466191;12489176;12791601;12810533;12904166;1370451;1383255;14962809;15040834;15108058;15126567;15153459;15308688;15329369;15469690;15485880;15525596;15642270;15664000;17047378;17249697;17312271;17985932;18162525;18547474;18597632;19005008;19998030;20581062;22341070;22582013;22766095;2476804;2479552;26091039;30287925;32712387;33097703;37453717;38253038;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;8781553;8817670;8894645;8964575;9497324;9709957;9733769;9786878;9922210",
        "class_list": "",
        "function": "Active sites of human MEPE-ASARM regulating bone matrix mineralization., [RefSeq, PubMed]; MEPE loss-of-function variant associates with decreased bone mineral density and increased fracture risk. Publication Status: Online-Only, [RefSeq, PubMed]; MEPE/OF45, a new dentin/bone matrix protein and candidate gene for dentin diseases mapping to chromosome 4q21. Expressed during odontogenesis., [RefSeq, PubMed]; Mice deficient in an ortholog of MEPE show increased bone mass and are resistant to aging-related bone loss., [RefSeq, PubMed]; Promotes renal phosphate excretion and inhibits intestinal phosphate absorption (PubMed:14962809, PubMed:19005008). Promotes bone mineralization by osteoblasts and cartilage mineralization by chondrocytes (PubMed:18162525, PubMed:19998030, PubMed:22766095). Regulates the mineralization of the extracellular matrix of the craniofacial complex, such as teeth, bone and cartilage (By similarity). Promotes dental pulp stem cell proliferation and differentiation (PubMed:22341070)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Sequencing identified a rare segregating heterozygous frameshift variant p.(Gln425Lysfs*38) in MEPE. We performed variant burden and variance components analyses in a large otosclerosis cohort and demonstrated that nonsense and frameshift MEPE variants were significantly enriched in affected subjects (p = 0.0006-0.0060)., [RefSeq, PubMed]; There is evidence for a hormone/enzyme/extracellular matrix protein cascade involving fibroblastic growth factor 23 (FGF23), a phosphate-regulating gene with homologies to (PHEX) and (MEPE)--REVIEW Review article, [RefSeq, PubMed]; This gene encodes a secreted calcium-binding phosphoprotein that belongs to the small integrin-binding ligand, N-linked glycoprotein (SIBLING) family of proteins. Members of this family are components of the extracellular matrix of bone and dentin and regulate bone mineralization. Deficiency of a similar protein in mouse results in increased bone mass. Mice lacking this gene are resistant to aging-related trabecular bone loss. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]., [RefSeq]",
        "predicted_glycosites": 2,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
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        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A4X9;A8MTA3;D2CFR4;F5H5C5",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990430 extracellular matrix protein binding;GO:0005201 extracellular matrix structural constituent",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005788 endoplasmic reticulum lumen;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0001501 skeletal system development;GO:0031214 biomineral tissue development",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "Q9NQ76-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WWZ8-1",
        "uniprot_id": [
            {
                "id": "OIT3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WWZ8",
                "type": "external"
            }
        ],
        "mass": 60022.0,
        "length": 545,
        "protein_name": "Oncoprotein-induced transcript 3 protein",
        "gene_name": "OIT3",
        "organism": "Human",
        "refseq_name": "oncoprotein-induced transcript 3 protein precursor",
        "refseq_ac": [
            {
                "id": "NP_689848",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689848",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OIT3; LZP; PRO1753",
        "gene_names_refseq": "LZP; OIT3",
        "protein_names_uniprotkb": "Oncoprotein-induced transcript 3 protein; Liver-specific zona pellucida domain-containing protein",
        "protein_names_refseq": "liver-specific ZP domain-containing protein; liver-specific zona pellucida domain-containing protein; oncoprotein-induced transcript 3 protein precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:170392)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "12939600;12975309;15589826;18830570;19159218;23090970;25824785;27862975;29391424;29671580;31154438;32569156;33592498;35051231;35353239;35580925;37201744",
        "class_list": "",
        "function": "D8C, a novel domain present in LZP, mutates in familial juvenile hyperuricemia., [RefSeq, PubMed]; Increased OIT3 in macrophages promotes PD-L1 expression and hepatocellular carcinogenesis via NF-kappaB signaling., [RefSeq, PubMed]; Liver-specific ZP domain-containing protein (LZP) is a liver-specific protein involved possibly in hepatocellular function and development. (liver-specific ZP domain-containing protein), [RefSeq, PubMed]; Loss of heterozygosity of OIT3 gene on chromosome 10q is associated with pancreatic cancer., [RefSeq, PubMed]; May be involved in hepatocellular function and development., [UniProtKB, PubMed]; OIT3 mediates macrophage polarization and facilitates hepatocellular carcinoma progression., [RefSeq, PubMed]; Rs554643826 (T439S) may have contributed to inheritance of gout in a Chinese family, [RefSeq, PubMed]; The finding that LZP might act as a new partner of THP would provide novel insights into renal functions related to THP and LZP, such as the urothelial permeability barrier and the host defense against the adhesion of pathogens., [RefSeq, PubMed]; This gene was identified due to its downregulation in hepatocarcinomas. The encoded protein may be involved in liver development and function. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 8593,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVP3;Q8N1M8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005635 nuclear envelope;GO:0009986 cell surface",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q8WWZ8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NWT1-1",
        "uniprot_id": [
            {
                "id": "PK1IP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NWT1",
                "type": "external"
            }
        ],
        "mass": 43964.0,
        "length": 392,
        "protein_name": "p21-activated protein kinase-interacting protein 1",
        "gene_name": "PAK1IP1",
        "organism": "Human",
        "refseq_name": "p21-activated protein kinase-interacting protein 1",
        "refseq_ac": [
            {
                "id": "NP_060376",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060376",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PAK1IP1; PIP1; WDR84",
        "gene_names_refseq": "MAK11; PAK1IP1; PIP1; WDR84; bA421M1.5; hPIP1",
        "protein_names_uniprotkb": "p21-activated protein kinase-interacting protein 1; PAK/PLC-interacting protein 1; PAK1-interacting protein 1; WD repeat-containing protein 84; hPIP1",
        "protein_names_refseq": "PAK/PLC-interacting protein 1; WD repeat-containing protein 84; p21-activated protein kinase-interacting protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55003)",
        "pathway_count": 1,
        "publication_count": 56,
        "publication_id_list": "11371639;12429849;17322306;18669648;19007248;19413330;19664995;19691289;20068231;21406692;22645359;23186163;23481700;23935987;24120868;24715725;25418920;25576301;26154972;26992070;27846572;28218747;28510447;28832583;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29786170;30315122;30524438;30779550;31154438;31844290;32157095;32265295;32387766;32488085;32502341;32897882;32938616;33392160;33592498;33912179;33968037;33981976;34087483;34509645;35051231;35318648;35580925;37217939;37938771",
        "class_list": "",
        "function": "A mutation in mouse Pak1ip1 causes orofacial clefting while human PAK1IP1 maps to 6p24 translocation breaking points associated with orofacial clefting. Publication Status: Online-Only, [RefSeq, PubMed]; Negatively regulates the PAK1 kinase. PAK1 is a member of the PAK kinase family, which has been shown to play a positive role in the regulation of signaling pathways involving MAPK8 and RELA. PAK1 exists as an inactive homodimer, which is activated by binding of small GTPases such as CDC42 to an N-terminal regulatory domain. PAK1IP1 also binds to the N-terminus of PAK1, and inhibits the specific activation of PAK1 by CDC42. May be involved in ribosomal large subunit assembly (PubMed:24120868)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
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        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T4J2;Q96QJ8;Q96T87",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004860 protein kinase inhibitor activity",
        "go_cellular_component": "GO:0005730 nucleolus",
        "go_biological_process": "GO:0042273 ribosomal large subunit biogenesis;GO:1901796 regulation of signal transduction by p53 class mediator;GO:0009968 negative regulation of signal transduction;GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "Q9NWT1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P20336-1",
        "uniprot_id": [
            {
                "id": "RAB3A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P20336",
                "type": "external"
            }
        ],
        "mass": 24984.0,
        "length": 220,
        "protein_name": "Ras-related protein Rab-3A",
        "gene_name": "RAB3A",
        "organism": "Human",
        "refseq_name": "ras-related protein Rab-3A",
        "refseq_ac": [
            {
                "id": "NP_002857",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002857",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAB3A",
        "gene_names_refseq": "RAB3A; SCA52",
        "protein_names_uniprotkb": "Ras-related protein Rab-3A; 3.6.5.2",
        "protein_names_refseq": "RAS-associated protein RAB3A; ras-related protein Rab-3A",
        "tax_id": 9606,
        "disease": "Smith-McCort dysplasia (Disease Ontology:DOID:0060247); Dyggve-Melchior-Clausen disease (Disease Ontology:DOID:0111167); alcohol use disorder (Disease Ontology:DOID:1574); epilepsy (Disease Ontology:DOID:1826)",
        "pathway": " (hsa:5864);  (R-HSA-181429);  (R-HSA-181430);  (R-HSA-210500);  (R-HSA-212676);  (R-HSA-264642);  (R-HSA-6798695);  (R-HSA-8873719);  (R-HSA-8876198);  (R-HSA-888590);  (R-HSA-9662360)",
        "pathway_count": 11,
        "publication_count": 270,
        "publication_id_list": "10025409;10440375;10574328;10620514;10818110;10859313;10990452;11001057;11015561;11017172;11027560;11038176;11068039;11141079;11163272;11179213;11237011;11242046;11389151;11447212;11516400;11675392;11689439;11703925;11746448;11756489;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12519779;12684051;12750892;12944476;12972505;1339386;15096524;15138286;1516130;15207266;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15935055;15958533;16116111;16207721;16373702;16401880;16410077;1648736;16525024;16525121;16571673;16616430;16641372;16722236;16754960;16880209;16950109;17043139;17114793;17132146;17189207;17208202;17239822;17287728;17301226;17411337;17478680;17488286;17562788;17574030;17646400;17671165;17678623;17766642;17891149;17989281;18076383;18094055;18215623;18354496;18367545;1845915;18477474;18532927;18559336;18585354;18617632;18664496;18701652;18779367;18804435;1900457;19077034;19109890;19345684;19375301;19403694;19490898;19603039;19620288;19656848;19725050;19729655;19745841;20008558;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22248876;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22694141;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23363473;23378591;23420520;23444368;23478338;23645161;23650620;23678941;23684622;23713133;23839779;24023390;24296415;24578174;24644286;24694596;24719330;24891604;24917561;24967941;2501306;25074980;25341920;25343031;25472813;25648148;25713415;25925668;26055712;26177209;26245486;26434594;26538022;26824392;26925400;26936971;26969162;26992070;27041585;27044746;27103185;27246931;27325790;27329675;28218747;28832583;2892215;29125462;29242379;29632711;29786170;30237463;30429286;30599141;31154438;31698103;31844290;3214421;32265295;33633747;35809645;35871249;36241641;38512027;7688123;7823026;7911226;7957092;7991565;8071310;8095030;8144603;8164745;8211186;8349690;8375503;8408203;8513495;8522602;8631982;8662963;8692836;8836150;8863739;9020086;9020161;9030515;9136770;9260930;9323142;9590177;9701566;9733780;9753324",
        "class_list": "",
        "function": "Molecular and functional interactions of alpha-synuclein with Rab3a., [RefSeq, PubMed]; RAB3 phosphorylation by pathogenic LRRK2 impairs trafficking of synaptic vesicle precursors., [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes (PubMed:2501306). Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:2501306). RAB3A plays a central role in regulated exocytosis and secretion. Controls the recruitment, tethering and docking of secretory vesicles to the plasma membrane (PubMed:2501306). Upon stimulation, switches to its active GTP-bound form, cycles to vesicles and recruits effectors such as RIMS1, RIMS2, Rabphilin-3A/RPH3A, RPH3AL or SYTL4 to help the docking of vesicules onto the plasma membrane (By similarity). Upon GTP hydrolysis by GTPase-activating protein, dissociates from the vesicle membrane allowing the exocytosis to proceed (By similarity). Stimulates insulin secretion through interaction with RIMS2 or RPH3AL effectors in pancreatic beta cells (By similarity). Regulates calcium-dependent lysosome exocytosis and plasma membrane repair (PMR) via the interaction with 2 effectors, SYTL4 and myosin-9/MYH9 (PubMed:27325790). Acts as a positive regulator of acrosome content secretion in sperm cells by interacting with RIMS1 (PubMed:22248876, PubMed:30599141). Also plays a role in the regulation of dopamine release by interacting with synaptotagmin I/SYT (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Unveiling the interaction between the molecular motor Myosin Vc and the small GTPase Rab3A., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "predicted_o_glycosites": 0,
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        "total_reported_o_glycosites": 1,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K0J4;Q9NYE1",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
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            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "3.4.24.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.11",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.4.11.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.2",
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            },
            {
                "id": "2.4.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-",
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            },
            {
                "id": "2.4.1.275",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.275",
                "type": "external"
            },
            {
                "id": "2.4.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22",
                "type": "external"
            },
            {
                "id": "2.4.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38",
                "type": "external"
            },
            {
                "id": "2.4.1.90",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "1.2.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5",
                "type": "external"
            },
            {
                "id": "1.2.1.28",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.28",
                "type": "external"
            },
            {
                "id": "1.2.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7",
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            },
            {
                "id": "1.2.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.48",
                "type": "external"
            },
            {
                "id": "2.5.1.60",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60",
                "type": "external"
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            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "4.1.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.15",
                "type": "external"
            },
            {
                "id": "7.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-",
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            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
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            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0046872 metal ion binding;GO:0030742 GTP-dependent protein binding",
        "go_cellular_component": "GO:0060201 clathrin-sculpted acetylcholine transport vesicle membrane;GO:0060203 clathrin-sculpted glutamate transport vesicle membrane;GO:0070083 clathrin-sculpted monoamine transport vesicle membrane;GO:0005768 endosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0001778 plasma membrane repair;GO:0097091 synaptic vesicle clustering;GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0045054 constitutive secretory pathway;GO:0061670 evoked neurotransmitter secretion",
        "synthesized_glycan_count": 0,
        "hit_score": 27.3,
        "record_id": "P20336-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P50579-1",
        "uniprot_id": [
            {
                "id": "MAP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P50579",
                "type": "external"
            }
        ],
        "mass": 52892.0,
        "length": 478,
        "protein_name": "Methionine aminopeptidase 2",
        "gene_name": "METAP2",
        "organism": "Human",
        "refseq_name": "methionine aminopeptidase 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001304111",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001304111",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METAP2; MNPEP; P67EIF2",
        "gene_names_refseq": "MAP2; METAP2; MNPEP; p67eIF2",
        "protein_names_uniprotkb": "Methionine aminopeptidase 2; 3.4.11.18; Initiation factor 2-associated 67 kDa glycoprotein; MAP 2; MetAP 2; Peptidase M; p67eIF2; p67",
        "protein_names_refseq": "eIF-2-associated p67 homolog; initiation factor 2-associated 67 kDa glycoprotein; methionine aminopeptidase 2 isoform 2; methionine aminopeptidase 2; peptidase M 2; testicular tissue protein Li 17",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10988);  (R-HSA-2514859)",
        "pathway_count": 2,
        "publication_count": 162,
        "publication_id_list": "10037746;10051575;10564809;10676965;11237011;11292825;11601986;11687658;11713293;11754336;12036349;12119397;12499365;12718546;12825937;1356371;1379636;1387789;1436039;14534293;14702087;15012983;15946941;16134930;16274222;16540317;16895762;16908407;17114291;17350258;17636946;18669648;18803695;19818506;1999465;20068231;20430952;20521764;20975703;21209280;21537465;21872626;22009320;22658984;23186163;23301498;24397554;24714562;24715725;2511207;2540796;2550422;25576301;2558719;25645385;25880248;26154972;26768311;26811146;26992070;27543614;27600516;27846572;27920218;28063628;28228285;28510447;28832583;28834231;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29769354;29786170;3006923;30315122;30410026;30484775;30524438;30779550;30833945;31154438;31217245;31222486;31530632;3164688;31844290;31848261;31937595;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32922205;32938616;32983136;33091337;33141586;33214551;33298915;33392160;33537174;33592498;33637565;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34405274;34509645;34561969;34932366;35051231;35251023;35254053;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37938771;38335281;38665916;40596516;4772407;6264430;7525588;7526403;7644482;7670478;7678445;7682292;7777544;7873610;7983048;8494894;8626439;8706659;8812493;9119368;9353336;9430683;9459445;9506952;9812898",
        "class_list": "",
        "function": "CHD1L promotes EOC cell invasiveness and metastasis via the regulation of METAP2. Publication Status: Online-Only, [RefSeq, PubMed]; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo., [UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB]; In Vivo Imaging of Methionine Aminopeptidase II for Prostate Cancer Risk Stratification., [RefSeq, PubMed]; Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis., [UniProtKB, UniProtKB, HAMAP, UniProtKB, UniProtKB]; Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons., [RefSeq, PubMed]; The protein encoded by this gene is a member of the methionyl aminopeptidase family. The encoded protein functions both by protecting the alpha subunit of eukaryotic initiation factor 2 from inhibitory phosphorylation and by removing the amino-terminal methionine residue from nascent proteins. Increased expression of this gene is associated with various forms of cancer, and the anti-cancer drugs fumagillin and ovalicin inhibit the protein by irreversibly binding to its active site. Inhibitors of this gene have also been shown to be effective for the treatment of obesity. A pseudogene of this gene is located on chromosome 2. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDI8;B4DUX5;G3XA91;Q8NB11",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.4.11.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.18",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0046872 metal ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity;GO:0070006 metalloaminopeptidase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0016485 protein processing;GO:0006446 regulation of translational initiation;GO:0006508 proteolysis",
        "synthesized_glycan_count": 0,
        "hit_score": 16.5,
        "record_id": "P50579-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NHP6-1",
        "uniprot_id": [
            {
                "id": "MSPD2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NHP6",
                "type": "external"
            }
        ],
        "mass": 59746.0,
        "length": 518,
        "protein_name": "Motile sperm domain-containing protein 2",
        "gene_name": "MOSPD2",
        "organism": "Human",
        "refseq_name": "motile sperm domain-containing protein 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001170946",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170946",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MOSPD2",
        "gene_names_refseq": "MOSPD2",
        "protein_names_uniprotkb": "Motile sperm domain-containing protein 2",
        "protein_names_refseq": "motile sperm domain-containing protein 2 isoform 2; motile sperm domain-containing protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:158747);  (R-HSA-6798695);  (R-HSA-9013405)",
        "pathway_count": 3,
        "publication_count": 73,
        "publication_id_list": "11237011;11784792;12577064;17064668;17081983;17916560;19413330;22665057;23087206;23096567;23650620;24102721;24714562;24715725;25418920;25576301;25645385;25746724;26154972;26929215;26992070;27481945;27600516;27846572;27852748;27862975;28137892;28218747;28486133;28510447;28832583;28834231;28947137;29242379;29437277;29493099;29557506;29632711;29776664;29786170;29789417;29858488;29978511;30315122;30410026;30429286;30784271;31020640;31154438;31530632;31844290;31848261;31871319;32157095;32161166;32350084;32357974;32897882;32938616;32983136;33124732;33592498;33717175;33968037;34357683;35051231;35389430;35580925;36010968;36284347;40307207;8692836;8945468",
        "class_list": "",
        "function": "Endoplasmic reticulum-anchored protein that mediates the formation of contact sites between the endoplasmic (ER) and endosomes, mitochondria or Golgi through interaction with conventional- and phosphorylated-FFAT-containing organelle-bound proteins (PubMed:29858488, PubMed:33124732, PubMed:35389430). In addition, forms endoplasmic reticulum (ER)-lipid droplets (LDs) contacts through a direct protein-membrane interaction and participates in LDs homeostasis (PubMed:35389430). The attachment mechanism involves an amphipathic helix that has an affinity for lipid packing defects present at the surface of LDs (PubMed:35389430). Promotes migration of primary monocytes and neutrophils, in response to various chemokines (PubMed:28137892)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Results indicate that motile sperm domain containing 2 (MOSPD2) plays a key role in the migration and metastasis of breast cancer cells and may be used to prevent the spreading of breast cancer cells and to mediate their death., [RefSeq, PubMed]; This study shows that silencing MOSPD2 inhibited signaling events following chemokine receptor ligation and monocyte migration induced by chemokines, [RefSeq, PubMed]; Thus, we characterized here MOSPD2, a novel tethering component related to VAP proteins(VAP-A and VAP-B), bridging the endoplasmic reticulum with a variety of distinct organelles., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N3H2;Q8NA83",
        "ec_number_list": [],
        "go_molecular_function": "GO:0033149 FFAT motif binding",
        "go_cellular_component": "GO:0044232 organelle membrane contact site;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0035579 specific granule membrane",
        "go_biological_process": "GO:0006935 chemotaxis;GO:0051260 protein homooligomerization;GO:0090026 positive regulation of monocyte chemotaxis;GO:0140042 lipid droplet formation;GO:0090023 positive regulation of neutrophil chemotaxis",
        "synthesized_glycan_count": 0,
        "hit_score": 7.6,
        "record_id": "Q8NHP6-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q12866-1",
        "uniprot_id": [
            {
                "id": "MERTK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q12866",
                "type": "external"
            }
        ],
        "mass": 110249.0,
        "length": 999,
        "protein_name": "Tyrosine-protein kinase Mer",
        "gene_name": "MERTK",
        "organism": "Human",
        "refseq_name": "tyrosine-protein kinase Mer precursor",
        "refseq_ac": [
            {
                "id": "NP_006334",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006334",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MERTK; MER",
        "gene_names_refseq": "MERTK; MER; RP38; Tyro12; c-Eyk; c-mer",
        "protein_names_uniprotkb": "Tyrosine-protein kinase Mer; 2.7.10.1; Proto-oncogene c-Mer; Receptor tyrosine kinase MerTK",
        "protein_names_refseq": "MER receptor tyrosine kinase; STK kinase; c-mer proto-oncogene tyrosine kinase; proto-oncogene c-Mer; receptor tyrosine kinase MerTK; tyrosine-protein kinase Mer precursor; tyrosine-protein kinase Mer",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa 38 (Disease Ontology:DOID:0110367); retinal degeneration (Disease Ontology:DOID:8466)",
        "pathway": " (hsa:10461);  (R-HSA-202733);  (R-HSA-9918485)",
        "pathway_count": 3,
        "publication_count": 123,
        "publication_id_list": "10.1101/2023.09.13.557529;10606205;10764623;11062461;11207550;11237011;11256994;11337487;11564780;11779189;11812992;12070135;12208882;12469115;12682107;12782713;12920122;14529530;14615387;15000751;15098107;15507651;15528364;15681301;15721307;15838506;1591491;16258728;16288044;16297198;16335952;16585556;16691243;16737840;16783819;17005688;17064312;17099249;17116209;17167768;17172599;17322099;17344846;17379836;17442946;17452516;17505016;17525755;17563375;17580308;17600130;17615384;17625065;18039660;18266465;18421305;19279206;19369195;19664995;21193412;21602930;21659548;21792939;23084921;23090970;23658209;23945545;24043627;24074594;24190977;24764293;2538457;26056282;26212330;26468529;27832191;29242379;29391424;29557506;29610346;29671580;29741879;29742433;30459171;30833945;31154438;31222486;31720911;31848261;32157095;32350084;32488085;32640697;33119085;33123756;33968037;34171305;35051231;35251023;35580925;37074911;38493215;38550672;38673989;38791148;39217874;468991;7509040;7521878;8086340;8163559;8166770;8314844;8702477;9052782;9160883;9169774;9242610;9295288;9382878;9693095;9763524;9931503",
        "class_list": "",
        "function": "Anti-inflammatory effects of MerTK by inducing M2 macrophage polarization via PI3K/Akt/GSK-3beta pathway in gout., [RefSeq, PubMed]; Axl and MerTK regulate synovial inflammation and are modulated by IL-6 inhibition in rheumatoid arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; MerTK Drives Proliferation and Metastatic Potential in Triple-Negative Breast Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment (PubMed:32640697). Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Also plays an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3., [UniProtKB, PubMed, PubMed]; Regulation of Mertk Surface Expression via ADAM17 and gamma-Secretase Proteolytic Processing. Publication Status: Online-Only, [RefSeq, PubMed]; The Important Role of Phosphatidylserine, ADAM17, TNF-Alpha, and Soluble MER on Efferocytosis Activity in Central Obesity. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the MER/AXL/TYRO3 receptor kinase family and encodes a transmembrane protein with two fibronectin type-III domains, two Ig-like C2-type (immunoglobulin-like) domains, and one tyrosine kinase domain. Mutations in this gene have been associated with disruption of the retinal pigment epithelium (RPE) phagocytosis pathway and onset of autosomal recessive retinitis pigmentosa (RP). [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 10,
        "predicted_n_glycosites": 8,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "reported_n_glycosites": 7,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 7,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 11,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 66,
        "reported_interactions": 0,
        "missing_score": 3939,
        "biomarker_type": "",
        "glycan_count": 28,
        "disease_count": 2,
        "glyco_site_count": 20,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9HBB4",
        "ec_number_list": [
            {
                "id": "6.2.1.45",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.45",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
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            },
            {
                "id": "3.4.21.75",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
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            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "6.2.1.64",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.64",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0004714 transmembrane receptor protein tyrosine kinase activity;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0001750 photoreceptor outer segment",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007166 cell surface receptor signaling pathway;GO:0007169 cell surface receptor protein tyrosine kinase signaling pathway;GO:0007267 cell-cell signaling;GO:0007399 nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 16.2,
        "record_id": "Q12866-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96BX8-1",
        "uniprot_id": [
            {
                "id": "MOB3A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96BX8",
                "type": "external"
            }
        ],
        "mass": 25464.0,
        "length": 217,
        "protein_name": "MOB kinase activator 3A",
        "gene_name": "MOB3A",
        "organism": "Human",
        "refseq_name": "MOB kinase activator 3A",
        "refseq_ac": [
            {
                "id": "NP_570719",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_570719",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MOB3A; MOBKL2A",
        "gene_names_refseq": "MOB-LAK; MOB1C; MOB3A; MOBKL2A; moblak",
        "protein_names_uniprotkb": "MOB kinase activator 3A; MOB-LAK; Mob1 homolog 2A; Mps one binder kinase activator-like 2A",
        "protein_names_refseq": "MOB LAK; MOB kinase activator 3A; MOB1, Mps One Binder kinase activator-like 2A; mob1 homolog 2A; mps one binder kinase activator-like 2A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:126308)",
        "pathway_count": 1,
        "publication_count": 67,
        "publication_id_list": "11237011;22424782;23481700;24029068;24366607;24714562;24715725;25418920;25576301;25802875;25892735;26154972;26375851;26728094;26811146;26992070;27846572;27920218;28063628;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30429286;30484775;31154438;31530632;31844290;31848261;32157095;32265295;32357974;32387766;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33717175;33912179;33936100;33968037;34185709;34357683;34509645;34932366;35046109;35051231;35318648;35580925;36215666;36241641;36581221",
        "class_list": "",
        "function": "MOB3A Bypasses BRAF and RAS Oncogene-Induced Senescence by Engaging the Hippo Pathway., [RefSeq, PubMed]; May regulate the activity of kinases., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KTF1;O75249;Q8TF69",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q96BX8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7L1V2-1",
        "uniprot_id": [
            {
                "id": "MON1B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7L1V2",
                "type": "external"
            }
        ],
        "mass": 59217.0,
        "length": 547,
        "protein_name": "Vacuolar fusion protein MON1 homolog B",
        "gene_name": "MON1B",
        "organism": "Human",
        "refseq_name": "vacuolar fusion protein MON1 homolog B isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001273568",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273568",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MON1B; HSRG1; KIAA0872; SAND2",
        "gene_names_refseq": "HSRG1; MON1B; SAND2; SRG1",
        "protein_names_uniprotkb": "Vacuolar fusion protein MON1 homolog B; HSV-1 stimulation-related gene 1 protein; HSV-I stimulating-related protein",
        "protein_names_refseq": "HSV-1 stimulation-related gene 1 protein; HSV-I stimulating-related protein; MON1 homolog B, secretory trafficking associated; MON1 secretory trafficking family member B; vacuolar fusion protein MON1 homolog B isoform 2; vacuolar fusion protein MON1 homolog B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22879);  (R-HSA-8876198)",
        "pathway_count": 2,
        "publication_count": 220,
        "publication_id_list": "10818110;10990452;11038176;11179213;11237011;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12828340;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17109635;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18701652;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19620288;19656848;19725050;19729655;19745841;19844255;19851296;20008558;20154091;20159109;20159556;20198315;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21509660;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23186163;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23645161;23678941;23684622;23713133;23839779;24296415;24644286;24694596;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25472813;25505266;25648148;25713415;25925668;26055712;26154972;26177209;26245486;26375851;26434594;26538022;26925400;26936971;26987402;26992070;27041585;27044746;27103185;27246931;27329675;27920218;28514659;28649982;28832583;28834231;28904123;29242379;29393594;29557506;29632046;30524438;31154438;31844290;31848261;32387766;32897882;32938616;33298915;33717175;33936100;33968037;34509645;34932366;35051231;35494241;35580925;7688123;7911226;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "HSRG1 interacts with SV40 large T antigen (LT) in yeast two-hybrid assay, [RefSeq, PubMed]; Identification of HSV-1 stimulation-related gene 1, a novel sand family protein, induced by herpes simplex virus 1 binding. (HSV-1 stimulation-related gene 1 (HSRG1), [RefSeq, PubMed]; Numb binds to another docking regulator, Mon1b, and is required for the recruitment of cytosolic Mon1b to the early endosomes membrane., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed, PubMed]; Plays an important role in membrane trafficking through the secretory apparatus., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DDZ0;O94949",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005770 late endosome;GO:0035658 Mon1-Ccz1 complex",
        "go_biological_process": "GO:0019085 early viral transcription;GO:0019086 late viral transcription;GO:0016192 vesicle-mediated transport;GO:0006623 protein targeting to vacuole",
        "synthesized_glycan_count": 0,
        "hit_score": 22.1,
        "record_id": "Q7L1V2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96EY8-1",
        "uniprot_id": [
            {
                "id": "MMAB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96EY8",
                "type": "external"
            }
        ],
        "mass": 27388.0,
        "length": 250,
        "protein_name": "Corrinoid adenosyltransferase MMAB",
        "gene_name": "MMAB",
        "organism": "Human",
        "refseq_name": "corrinoid adenosyltransferase MMAB precursor",
        "refseq_ac": [
            {
                "id": "NP_443077",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443077",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MMAB",
        "gene_names_refseq": "ATR; CFAP23; MMAB; cblB; cob",
        "protein_names_uniprotkb": "Corrinoid adenosyltransferase MMAB; 2.5.1.-; ATP:co(I)rrinoid adenosyltransferase MMAB; Methylmalonic aciduria type B protein",
        "protein_names_refseq": "ATP:co(I)rrinoid adenosyltransferase MMAB; ATP:cob(I)alamin adenosyltransferase; ATP:corrinoid adenosyltransferase; aquocob(I)alamin vitamin B12s adenosyltransferase; cilia and flagella associated protein 23; cob(I)yrinic acid a,c-diamide adenosyltransferase, mitochondrial; cob(II)alamin adenosyltransferase; cob(II)yrinic acid a,c-diamide adenosyltransferase; cobinamide/cobalamin adenosyltransferase; corrinoid adenosyltransferase MMAB precursor; corrinoid adenosyltransferase MMAB; methylmalonic aciduria (cobalamin deficiency) cblB type; methylmalonic aciduria type B protein",
        "tax_id": 9606,
        "disease": "methylmalonic acidemia cblB type (Disease Ontology:DOID:0060743); methylmalonic acidemia (Disease Ontology:DOID:14749); inherited metabolic disorder (Disease Ontology:DOID:655)",
        "pathway": " (hsa:326625);  (R-HSA-3359471);  (R-HSA-9759218)",
        "pathway_count": 3,
        "publication_count": 59,
        "publication_id_list": "10444342;10484769;10978155;11237011;12375236;12438653;12471062;12514191;15347655;15523652;15781192;15913339;16281286;16311595;17176040;17477549;17892308;17957493;18251506;18385497;18779575;19243433;19447654;19801555;20068230;20657474;21071249;21697092;22156578;22832074;23270877;23301498;24275569;2567699;25880248;27846572;28063628;28218747;28497574;28904123;29437277;29632046;29786170;30282455;31492838;31844290;32387766;32938616;33797888;33912179;33968037;34357683;34509645;34561969;34750386;36241641;40596516;4390543;8968737",
        "class_list": "",
        "function": "Converts cob(I)alamin to adenosylcobalamin (adenosylcob(III)alamin), a coenzyme for methylmalonyl-CoA mutase, therefore participates in the final step of the vitamin B12 conversion (PubMed:12514191). Generates adenosylcobalamin (AdoCbl) and directly delivers the cofactor to MUT in a transfer that is stimulated by ATP-binding to MMAB and gated by MMAA (Probable)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; MMAB promotes negative feedback control of cholesterol homeostasis. Publication Status: Online-Only, [RefSeq, PubMed]; Report the identification of ATR cDNA as well as the corresponding gene; ATR expression is altered in cell lines derived from cblB methylmalonyl aciduria patients; propose that inborn errors in the ATR gene identified here result in methylmalonyl aciduria, [RefSeq, PubMed]; Results describe two common polymorphic variants of ATP:cob(I)alamin adenosyltransferase that are found in normal individuals, and their interactions with methionine synthase reductase., [RefSeq, PubMed]; This gene encodes a protein that catalyzes the final step in the conversion of vitamin B(12) into adenosylcobalamin (AdoCbl), a vitamin B12-containing coenzyme for methylmalonyl-CoA mutase. Mutations in the gene are the cause of vitamin B12-dependent methylmalonic aciduria linked to the cblB complementation group. Alternatively spliced transcript variants have been found. [provided by RefSeq, Apr 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C5HU05;Q9BSH0",
        "ec_number_list": [
            {
                "id": "2.5.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0031419 cobalamin binding;GO:0016765 transferase activity, transferring alkyl or aryl (other than methyl) groups;GO:0008817 corrinoid adenosyltransferase activity;GO:0016740 transferase activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0009235 cobalamin metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q96EY8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N6Q8-1",
        "uniprot_id": [
            {
                "id": "MET25_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N6Q8",
                "type": "external"
            }
        ],
        "mass": 68213.0,
        "length": 603,
        "protein_name": "Probable methyltransferase-like protein 25",
        "gene_name": "METTL25",
        "organism": "Human",
        "refseq_name": "probable methyltransferase-like protein 25 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001306604",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001306604",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL25; C12orf26",
        "gene_names_refseq": "C12orf26; METTL25",
        "protein_names_uniprotkb": "Probable methyltransferase-like protein 25; 2.1.1.-",
        "protein_names_refseq": "methyltransferase-like protein 25; probable methyltransferase-like protein 25 isoform 2; probable methyltransferase-like protein 25",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84190)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;25880248;27600516;28063628;28832583;29242379;29393594;30315122;31844290;32357974;32387766;32488085;32502341;33968037",
        "class_list": "",
        "function": "Probable methyltransferase., [UniProtKB]",
        "predicted_glycosites": 1,
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        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9H5Y3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008168 methyltransferase activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q8N6Q8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96IZ6-1",
        "uniprot_id": [
            {
                "id": "MET2A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96IZ6",
                "type": "external"
            }
        ],
        "mass": 43537.0,
        "length": 378,
        "protein_name": "tRNA N(3)-cytidine methyltransferase METTL2A",
        "gene_name": "METTL2A",
        "organism": "Human",
        "refseq_name": "tRNA N(3)-cytidine methyltransferase METTL2A",
        "refseq_ac": [
            {
                "id": "NP_859076",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_859076",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL2A; HSPC266; METTL2",
        "gene_names_refseq": "METTL2A; METTL2",
        "protein_names_uniprotkb": "tRNA N(3)-cytidine methyltransferase METTL2A; 2.1.1.-; Methyltransferase-like protein 2A",
        "protein_names_refseq": "methyltransferase 2A, methylcytidine; methyltransferase like 2A; methyltransferase-like protein 2A; tRNA N(3)-cytidine methyltransferase METTL2A; tRNA N(3)-methylcytidine methyltransferase METTL2A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:339175)",
        "pathway_count": 1,
        "publication_count": 31,
        "publication_id_list": "11237011;20112406;25418920;25576301;25892735;26154972;26929215;26992070;27920218;28228285;28655767;28832583;28904123;29242379;29331515;29393594;29632046;30315122;30524438;31217245;31844290;32265295;32427860;32502341;33537174;33912179;34087483;34171305;34268557;35580925;36266694",
        "class_list": "",
        "function": "Data, including data from studies using mutant/knockout mice and cell lines from such mice, suggest that METTL2 and METTL6 (but not METTL8) contribute to post-transcriptional methylation of cytidine (formation of 3-methylcytidine) in tRNA; METTL2 methylates tRNA(Thr) and tRNA(Arg); METTL6 interacts with seryl-tRNA synthetase and methylates tRNA(Ser); METTL8 catalyzes post-transcriptional methylation of cytidine in mRNA., [RefSeq, PubMed]; Integrative analysis of m3C associated genes reveals METTL2A as a potential oncogene in breast Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU) (PubMed:28655767, PubMed:34268557). N(3)-methylcytidine methylation by METTL2A requires the N6-threonylcarbamoylation of tRNA (t6A37) by the EKC/KEOPS complex as prerequisite (PubMed:34268557)., [UniProtKB, PubMed, PubMed]; S-adenosyl-L-methionine-dependent methyltransferase., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NNC4;Q9H9G9;Q9NUI8;Q9P0B5",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0052735 tRNA (cytidine-3-)-methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0008173 RNA methyltransferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006399 tRNA metabolic process;GO:0006400 tRNA modification;GO:0030488 tRNA methylation;GO:0008033 tRNA processing;GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q96IZ6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86W50-1",
        "uniprot_id": [
            {
                "id": "MET16_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86W50",
                "type": "external"
            }
        ],
        "mass": 63621.0,
        "length": 562,
        "protein_name": "RNA N(6)-adenosine-methyltransferase METTL16",
        "gene_name": "METTL16",
        "organism": "Human",
        "refseq_name": "RNA N(6)-adenosine-methyltransferase METTL16",
        "refseq_ac": [
            {
                "id": "NP_076991",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_076991",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL16; METT10D",
        "gene_names_refseq": "METT10D; METTL16",
        "protein_names_uniprotkb": "RNA N(6)-adenosine-methyltransferase METTL16; 2.1.1.346; 2.1.1.348; Methyltransferase 10 domain-containing protein; Methyltransferase-like protein 16; U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase",
        "protein_names_refseq": "N6-adenosine-methyltransferase METTL16; N6-methyladenosine methyltransferase; RNA N(6)-adenosine-methyltransferase METTL16; RNA N6-adenosine-methyltransferase METTL16; U6 small nuclear RNA (adenine-(43)-N(6))-methyltransferase; U6 snRNA methyltransferase; methyltransferase 10 domain containing; methyltransferase 10 domain-containing protein; methyltransferase 16, N6-methyladenosine; methyltransferase like 16; methyltransferase-like protein 16; putative methyltransferase METT10D",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79066)",
        "pathway_count": 1,
        "publication_count": 52,
        "publication_id_list": "11237011;18077418;18669648;18691976;20602751;23186163;24715725;26154972;26375851;27846572;27862975;27872311;27920218;28228285;28514659;28525753;28832583;29051200;29242379;29393594;29508533;29557506;29593291;29632711;29789417;30197297;30197299;30315122;30429286;31154438;31844290;31940410;32157095;32266935;32357974;32502341;32938616;33298915;33428944;33537174;33968037;34019948;35051231;35561310;35580925;36010968;36284347;38334797;38385084;38605226;39218945;39247832",
        "class_list": "",
        "function": "A Mettl16/m[6]A/mybl2b/Igf2bp1 axis ensures cell cycle progression of embryonic hematopoietic stem and progenitor cells., [RefSeq, PubMed]; METTL16 Promotes Stability of SYNPO2L mRNA and leading to Cancer Cell Lung Metastasis by Secretion of COL10A1 and attract the Cancer-Associated Fibroblasts. Publication Status: Online-Only, [RefSeq, PubMed]; METTL16 inhibits papillary thyroid cancer tumorigenicity through m[6]A/YTHDC2/SCD1-regulated lipid metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; METTL16 suppressed the proliferation and cisplatin-chemoresistance of bladder cancer by degrading PMEPA1 mRNA in a m6A manner through autophagy pathway. Publication Status: Online-Only, [RefSeq, PubMed]; METTL16-SENP3-LTF axis confers ferroptosis resistance and facilitates tumorigenesis in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts (PubMed:28525753, PubMed:30197297, PubMed:30197299, PubMed:33428944, PubMed:33930289). Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs) (PubMed:28525753). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure (PubMed:28525753, PubMed:30197297, PubMed:30197299). Plays a key role in S-adenosyl-L-methionine homeostasis by mediating N6-methylation of MAT2A mRNAs, altering splicing of MAT2A transcripts: in presence of S-adenosyl-L-methionine, binds the 3'-UTR region of MAT2A mRNA and specifically N6-methylates the first hairpin of MAT2A mRNA, preventing recognition of their 3'-splice site by U2AF1/U2AF35, thereby inhibiting splicing and protein production of S-adenosylmethionine synthase (PubMed:28525753, PubMed:33930289). In S-adenosyl-L-methionine-limiting conditions, binds the 3'-UTR region of MAT2A mRNA but stalls due to the lack of a methyl donor, preventing N6-methylation and promoting expression of MAT2A (PubMed:28525753). In addition to mRNAs, also able to mediate N6-methylation of U6 small nuclear RNA (U6 snRNA): specifically N6-methylates adenine in position 43 of U6 snRNAs (PubMed:28525753, PubMed:29051200, PubMed:32266935). Also able to bind various lncRNAs, such as 7SK snRNA (7SK RNA) or 7SL RNA (PubMed:29051200). Specifically binds the 3'-end of the MALAT1 long non-coding RNA (PubMed:27872311)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 25,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DTI8;Q86TE5;Q96T16;Q9BVG7",
        "ec_number_list": [
            {
                "id": "1.13.11.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.11.27",
                "type": "external"
            },
            {
                "id": "2.1.1.348",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.348",
                "type": "external"
            },
            {
                "id": "2.1.1.346",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.346",
                "type": "external"
            },
            {
                "id": "2.1.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.9",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0001734 mRNA m(6)A methyltransferase activity;GO:0003723 RNA binding;GO:0035613 RNA stem-loop binding;GO:0030629 U6 snRNA 3'-end binding;GO:0052907 23S rRNA (adenine(1618)-N(6))-methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0010608 post-transcriptional regulation of gene expression;GO:0006402 mRNA catabolic process;GO:0006556 S-adenosylmethionine biosynthetic process;GO:0061157 mRNA destabilization",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q86W50-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N468-1",
        "uniprot_id": [
            {
                "id": "S60A1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N468",
                "type": "external"
            }
        ],
        "mass": 56265.0,
        "length": 514,
        "protein_name": "Solute carrier family 60 member 1",
        "gene_name": "SLC60A1",
        "organism": "Human",
        "refseq_name": "solute carrier family 60 member 1",
        "refseq_ac": [
            {
                "id": "NP_857595",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_857595",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC60A1; MFSD4A; MFSD4; PRO9894",
        "gene_names_refseq": "MFSD4A; MFSD4; SLC60A1; UNQ3064",
        "protein_names_uniprotkb": "Solute carrier family 60 member 1; Major facilitator superfamily domain-containing protein 4A; Major facilitator superfamily domain-containing protein 4",
        "protein_names_refseq": "major facilitator superfamily domain containing 4A; major facilitator superfamily domain containing 4; major facilitator superfamily domain-containing protein 4A; major facilitator superfamily domain-containing protein 4; solute carrier family 60 member 1",
        "tax_id": 9606,
        "disease": "cholangiocarcinoma (Disease Ontology:DOID:4947)",
        "pathway": " (hsa:148808)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;12975309;26872374;28228285;29049335;34087483;35051231",
        "class_list": "",
        "function": "Low MFSD4 expression is associated with hepatic metastasis in patients gastric cancer., [RefSeq, PubMed]; Propose MFSD4A and MFSD9 to be novel transporters, belonging to disparate SLC families. Both proteins were located to neurons in mouse brain, and their mRNA expression levels were affected by the diet Erratum:[PLoS One. 2018 May 10;13(5):e0197417. doi: 10.1371/journal.pone.0197417. PMID: 29746586] Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z8X3;Q6UY25;Q8NAY0;Q8TCP4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q8N468-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99583-1",
        "uniprot_id": [
            {
                "id": "MNT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99583",
                "type": "external"
            }
        ],
        "mass": 62300.0,
        "length": 582,
        "protein_name": "Max-binding protein MNT",
        "gene_name": "MNT",
        "organism": "Human",
        "refseq_name": "max-binding protein MNT",
        "refseq_ac": [
            {
                "id": "NP_064706",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064706",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MNT; BHLHD3; ROX",
        "gene_names_refseq": "MAD6; MNT; MXD6; ROX; bHLHd3; lncRNA-HAL",
        "protein_names_uniprotkb": "Max-binding protein MNT; Class D basic helix-loop-helix protein 3; Myc antagonist MNT; Protein ROX; bHLHd3",
        "protein_names_refseq": "MAX binding protein; MNT, MAX dimerization protein; Max-interacting protein; class D basic helix-loop-helix protein 3; max-binding protein MNT; myc antagonist MNT",
        "tax_id": 9606,
        "disease": "Miller-Dieker lissencephaly syndrome (Disease Ontology:DOID:0060469)",
        "pathway": " (hsa:4335)",
        "pathway_count": 1,
        "publication_count": 46,
        "publication_id_list": "11237011;18691976;19664995;20068231;23481700;24715725;25576301;25892735;26992070;27600516;28832583;28904123;29242379;29351928;29393594;29557506;29769354;30429286;30484775;31217245;31844290;31919096;32157095;32161166;32387766;32897882;32938616;33214551;33298915;33691108;33968037;34019948;34171305;34460331;34509645;35051231;35580925;36010968;36215666;36284347;38665916;38831092;39302247;39534244;9184233;9598315",
        "class_list": "",
        "function": "Binds DNA as a heterodimer with MAX and represses transcription. Binds to the canonical E box sequence 5'-CACGTG-3' and, with higher affinity, to 5'-CACGCG-3'., [UniProtKB]; MNT inhibits lung adenocarcinoma ferroptosis and chemosensitivity by suppressing SAT1. Publication Status: Online-Only, [RefSeq, PubMed]; Mnt Represses Epithelial Identity To Promote Epithelial-to-Mesenchymal Transition., [RefSeq, PubMed]; The MNT transcription factor autoregulates its expression and supports proliferation in MYC-associated factor X (MAX)-deficient cells., [RefSeq, PubMed]; The Myc/Max/Mad network comprises a group of transcription factors that co-interact to regulate gene-specific transcriptional activation or repression. This gene encodes a protein member of the Myc/Max/Mad network. This protein has a basic-Helix-Loop-Helix-zipper domain (bHLHzip) with which it binds the canonical DNA sequence CANNTG, known as the E box, following heterodimerization with Max proteins. This protein is likely a transcriptional repressor and an antagonist of Myc-dependent transcriptional activation and cell growth. This protein represses transcription by binding to DNA binding proteins at its N-terminal Sin3-interaction domain. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6D1;D3DTI7;Q1ED38",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q99583-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BUR5-1",
        "uniprot_id": [
            {
                "id": "MIC26_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BUR5",
                "type": "external"
            }
        ],
        "mass": 22285.0,
        "length": 198,
        "protein_name": "MICOS complex subunit MIC26",
        "gene_name": "APOO",
        "organism": "Human",
        "refseq_name": "MICOS complex subunit MIC26 precursor",
        "refseq_ac": [
            {
                "id": "NP_077027",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_077027",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "APOO; FAM121B; MIC23; MIC26; My025; PRO4302",
        "gene_names_refseq": "APOO; FAM121B; MIC26; MICOS26; Mic23; My025",
        "protein_names_uniprotkb": "MICOS complex subunit MIC26; Apolipoprotein O; MICOS complex subunit MIC23; Protein FAM121B",
        "protein_names_refseq": "MICOS complex subunit MIC23; MICOS complex subunit MIC26 precursor; MICOS complex subunit MIC26; brain my025; family with sequence similarity 121B; mitochondrial contact site and cristae organizing system subunit 26",
        "tax_id": 9606,
        "disease": "syndrome (Disease Ontology:DOID:225)",
        "pathway": " (hsa:79135);  (R-HSA-8949613)",
        "pathway_count": 2,
        "publication_count": 70,
        "publication_id_list": "11237011;12975309;16956892;17121862;17510655;17624330;18323778;19204726;19913121;20628086;20833715;21836051;22114354;22252321;22864911;23481700;24098383;24687277;24714562;24743151;25285856;25576301;25645385;25764979;25781180;25997101;26154972;26375851;26416881;26477565;26530328;26728094;26968360;26992070;27479602;27485409;27600516;27623147;27846572;28218747;28228285;28834231;28904123;29242379;29437277;29557506;30315122;30429286;30484775;31844290;32157095;32439808;32488085;32502341;32788226;32938616;33537174;33592498;33717175;33912179;34932366;35051231;35580925;35588578;36010968;36215666;36241641;37649161;37938771;39990658",
        "class_list": "glycogene",
        "function": "A X-linked nonsense APOO/MIC26 variant causes a lethal mitochondrial disease with progeria-like phenotypes., [RefSeq, PubMed]; Apolipoprotein O is the first chondroitin sulfate chain containing apolipoprotein, [RefSeq, PubMed]; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; MIC26 and MIC27 cooperate to regulate cardiolipin levels and the landscape of OXPHOS complexes. Publication Status: Online-Only, [RefSeq, PubMed]; Mutation in the MICOS subunit gene APOO (MIC26) associated with an X-linked recessive mitochondrial myopathy, lactic acidosis, cognitive impairment and autistic features., [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; Role of apolipoprotein O in autophagy via the p38 mitogen-activated protein kinase signaling pathway in myocardial infarction. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the apolipoprotein family. Members of this protein family are involved in the transport and metabolism of lipids. The encoded protein associates with HDL, LDL and VLDL lipoproteins and is characterized by chondroitin-sulfate glycosylation. This protein may be involved in preventing lipid accumulation in the myocardium in obese and diabetic patients. Alternative splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 4, 5, 12 and 16.[provided by RefSeq, Sep 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "reported_phosphosites": 0,
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        "reported_snv": 195,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R4K9;Q9H3J9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0001401 SAM complex;GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006869 lipid transport;GO:0042407 cristae formation;GO:0007007 inner mitochondrial membrane organization",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "Q9BUR5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001000.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NU22-1",
        "uniprot_id": [
            {
                "id": "MDN1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NU22",
                "type": "external"
            }
        ],
        "mass": 632820.0,
        "length": 5596,
        "protein_name": "Midasin",
        "gene_name": "MDN1",
        "organism": "Human",
        "refseq_name": "midasin",
        "refseq_ac": [
            {
                "id": "NP_055426",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055426",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MDN1; KIAA0301",
        "gene_names_refseq": "MDN1; Rea1",
        "protein_names_uniprotkb": "Midasin; Dynein-related AAA-ATPase MDN1; MIDAS-containing protein",
        "protein_names_refseq": "MDN1, midasin homolog; MIDAS-containing protein; dynein-related AAA-ATPase MDN1; midasin",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23195)",
        "pathway_count": 1,
        "publication_count": 138,
        "publication_id_list": "10.1101/2023.09.13.557529;12102729;15302935;17081983;17547437;18452278;18491316;18669648;18691976;18991276;19369195;19413330;19608861;19651622;19664994;19664995;19690332;19691289;20068231;21406692;21872626;22002106;22424782;22645359;22706990;22869377;22898188;23186163;23481700;24366607;24397554;24714562;24715725;25418920;25576301;25645385;25880248;25892735;26024233;26154972;26375851;26601951;26728094;26768311;26811146;26992070;27397612;27543614;27600516;27814492;27846572;27862975;27920218;28063628;28218747;28228285;28510447;28514659;28832583;28834231;28855257;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30192525;30237853;30315122;30379171;30410026;30429286;30484775;30524438;30620550;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34405274;34509645;34561969;34932366;35051231;35083852;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37217939;37938771;38253038;40596516",
        "class_list": "",
        "function": "Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits (PubMed:27814492). Functions at successive maturation steps to remove ribosomal factors at critical transition points, first driving the exit of early pre-60S particles from the nucleolus and then driving late pre-60S particles from the nucleus (By similarity). At an early stage in 60S maturation, mediates the dissociation of the PeBoW complex (PES1-BOP1-WDR12) from early pre-60S particles, rendering them competent for export from the nucleolus to the nucleoplasm (By similarity). Subsequently recruited to the nucleoplasmic particles through interaction with SUMO-conjugated PELP1 complex (PubMed:27814492). This binding is only possible if the 5S RNP at the central protuberance has undergone the rotation to complete its maturation (By similarity)., [UniProtKB, UniProtKB, PubMed]; The crystal structure of the UBL domain of the WDR12 homologue from S. cerevisiae at 1.7 A resolution is reported and demonstrated that human midasin binds to WDR12 as well as Nle1 through their respective UBL domains., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
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        "reported_o_glycosites_with_glycan": 3,
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        "biomarker_type": "",
        "glycan_count": 11,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "O15019;Q5T794",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "GO:0000027 ribosomal large subunit assembly;GO:0000448 cleavage in ITS2 between 5.8S rRNA and LSU-rRNA of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)",
        "synthesized_glycan_count": 0,
        "hit_score": 15.5,
        "record_id": "Q9NU22-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.000100.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H579-1",
        "uniprot_id": [
            {
                "id": "MROH8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H579",
                "type": "external"
            }
        ],
        "mass": 54816.0,
        "length": 483,
        "protein_name": "Protein MROH8",
        "gene_name": "MROH8",
        "organism": "Human",
        "refseq_name": "protein MROH8 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_689716",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689716",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MROH8; C20orf131; C20orf132",
        "gene_names_refseq": "C20orf131; C20orf132; MROH8",
        "protein_names_uniprotkb": "Protein MROH8; Maestro heat-like repeat-containing protein family member 8",
        "protein_names_refseq": "maestro heat-like repeat-containing protein family member 8; protein MROH8 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:140699)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;28228285;28832583;30192525;31154438;31217245;31844290;32157095;32357974;32387766;32938616;33392160;33936100;33968037;34509645;35051231;35580925;37217939;39894887",
        "class_list": "",
        "function": "The protein encoded by this gene belongs to the maestro heat-like repeat family. The exact function of this gene is not known, however, in a genome-wide association study using hippocampal atrophy as a quantitative trait, this gene has been associated with Alzheimer's disease (PMID:19668339). Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5JYQ6",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q9H579-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96LU7-1",
        "uniprot_id": [
            {
                "id": "MRFL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96LU7",
                "type": "external"
            }
        ],
        "mass": 101670.0,
        "length": 910,
        "protein_name": "Myelin regulatory factor-like protein",
        "gene_name": "MYRFL",
        "organism": "Human",
        "refseq_name": "myelin regulatory factor-like protein",
        "refseq_ac": [
            {
                "id": "NP_872336",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_872336",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYRFL; C12orf15; C12orf28",
        "gene_names_refseq": "C12orf15; C12orf28; MYRFL; bcm1377",
        "protein_names_uniprotkb": "Myelin regulatory factor-like protein",
        "protein_names_refseq": "myelin regulatory factor-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:196446)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;30379171;31828317;31844290;33592498;35051231;35254053",
        "class_list": "",
        "function": "By characterization of the exact DNA-binding requirements of Myrf, we furthermore show that cooperative activation is a consequence of joint binding of Sox10 and Myrf to the same regulatory regions., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "predicted_c_glycosites": 0,
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0043565 sequence-specific DNA binding;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0016540 protein autoprocessing",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q96LU7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P23297-1",
        "uniprot_id": [
            {
                "id": "S10A1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P23297",
                "type": "external"
            }
        ],
        "mass": 10546.0,
        "length": 94,
        "protein_name": "Protein S100-A1",
        "gene_name": "S100A1",
        "organism": "Human",
        "refseq_name": "protein S100-A1",
        "refseq_ac": [
            {
                "id": "NP_006262",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006262",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "S100A1; S100A",
        "gene_names_refseq": "S100-alpha; S100A1; S100A; S100",
        "protein_names_uniprotkb": "Protein S100-A1; S-100 protein alpha chain; S-100 protein subunit alpha; S100 calcium-binding protein A1",
        "protein_names_refseq": "S-100 protein alpha chain; S-100 protein subunit alpha; S100 alpha; S100 protein, alpha polypeptide; protein S100-A1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6271);  (R-HSA-1236974);  (R-HSA-166058);  (R-HSA-5602498);  (R-HSA-5603041);  (R-HSA-5686938)",
        "pathway_count": 6,
        "publication_count": 100,
        "publication_id_list": "10465784;11237011;11509636;11544529;11717446;11724772;11960013;12042313;12110890;12138165;12140561;12214235;12297423;12447441;12447442;12637671;12724322;12804600;12817025;1384693;14625308;15171681;15585605;15885104;15944945;16024789;16213021;16439361;16751103;16754682;16834340;16855214;16878026;17141195;17485511;17726518;17767165;17878161;17878374;17890055;17893200;18070880;18070982;18354232;18438411;18559343;18650434;18669862;18692471;18829464;18990700;19054851;19112167;19217269;19224918;19498957;19506249;19509286;19592493;19592497;20037584;20188096;20473308;20485341;20966070;21296671;21606490;21871094;22153078;22344226;22399290;22454496;22489132;22989881;23351007;23446148;23613522;24316379;24833748;24840642;25083866;25880347;27600516;27742543;28368280;30115681;31608988;31844290;32157095;32488085;35318648;35580925;37005977;37601265;37627239;37943051;7685021;8837778;9008162;9430229",
        "class_list": "",
        "function": "S-100 and MATH-1 Protein Expressions Can Be Useful for the Prediction of Clinical Outcome in Neuroblastoma Patients., [RefSeq, PubMed]; S100s and HMGB1 Crosstalk in Pancreatic Cancer Tumors. Publication Status: Online-Only, [RefSeq, PubMed]; Small calcium binding protein that plays important roles in several biological processes such as Ca(2+) homeostasis, chondrocyte biology and cardiomyocyte regulation (PubMed:12804600). In response to an increase in intracellular Ca(2+) levels, binds calcium which triggers conformational changes (PubMed:23351007). These changes allow interactions with specific target proteins and modulate their activity (PubMed:22399290). Regulates a network in cardiomyocytes controlling sarcoplasmic reticulum Ca(2+) cycling and mitochondrial function through interaction with the ryanodine receptors RYR1 and RYR2, sarcoplasmic reticulum Ca(2+)-ATPase/ATP2A2 and mitochondrial F1-ATPase (PubMed:12804600). Facilitates diastolic Ca(2+) dissociation and myofilament mechanics in order to improve relaxation during diastole (PubMed:11717446)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Tailored modulation of S100A1 and RASSF8 expression by butanediamide augments healing of rotator cuff tears. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in stimulation of Ca2+-induced Ca2+ release, inhibition of microtubule assembly, and inhibition of protein kinase C-mediated phosphorylation. Reduced expression of this protein has been implicated in cardiomyopathies. [provided by RefSeq, Jul 2008]., [RefSeq]; Up-Regulation of S100 Gene Family in Brain Samples of a Subgroup of Individuals with Schizophrenia: Meta-analysis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5D9;Q5T7Y3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0048306 calcium-dependent protein binding;GO:0051117 ATPase binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:1903672 positive regulation of sprouting angiogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0035556 intracellular signal transduction;GO:0021762 substantia nigra development;GO:0042311 vasodilation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.1,
        "record_id": "P23297-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P54278-1",
        "uniprot_id": [
            {
                "id": "PMS2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P54278",
                "type": "external"
            }
        ],
        "mass": 95797.0,
        "length": 862,
        "protein_name": "Mismatch repair endonuclease PMS2",
        "gene_name": "PMS2",
        "organism": "Human",
        "refseq_name": "mismatch repair endonuclease PMS2 isoform d",
        "refseq_ac": [
            {
                "id": "NP_001308936",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308936",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PMS2; PMSL2",
        "gene_names_refseq": "HNPCC4; LYNCH4; MLH4; MMRCS4; PMS-2; PMS2; PMSL2",
        "protein_names_uniprotkb": "Mismatch repair endonuclease PMS2; 3.1.-.-; DNA mismatch repair protein PMS2; PMS1 protein homolog 2",
        "protein_names_refseq": "DNA mismatch repair protein PMS2; PMS1 homolog 2, mismatch repair protein; PMS1 protein homolog 2; PMS2 postmeiotic segregation increased 2; mismatch repair endonuclease PMS2 isoform d; mismatch repair endonuclease PMS2",
        "tax_id": 9606,
        "disease": "hereditary nonpolyposis colorectal cancer type 4 (Disease Ontology:DOID:0070275); mismatch repair cancer syndrome (Disease Ontology:DOID:0112182); prostate cancer (Disease Ontology:DOID:10283); urinary bladder cancer (Disease Ontology:DOID:11054); breast cancer (Disease Ontology:DOID:1612); ovarian cancer (Disease Ontology:DOID:2394); Lynch syndrome (Disease Ontology:DOID:3883); mismatch repair cancer syndrome 4 (MONDO:MONDO:0030843)",
        "pathway": " (hsa:5395);  (R-HSA-5358565);  (R-HSA-5358606);  (R-HSA-5545483);  (R-HSA-5632987);  (R-HSA-6796648)",
        "pathway_count": 6,
        "publication_count": 141,
        "publication_id_list": "10078208;10473346;10480359;10660545;10783165;10938287;10984493;11005803;11237011;11274057;11350971;11441019;11574484;11698410;11793469;11809771;11809883;11884592;11971958;11988847;14636568;14676842;15077197;15225546;15781865;15887124;16143102;16188885;16464020;16472587;16619239;16793375;16855289;16873053;16873062;17426132;17531815;17557300;17984070;18157157;18178629;18206974;18326858;18602922;19228687;19479271;20068231;20154325;20160730;20186689;20205264;20571119;20603073;20713735;20970388;21496642;21561855;21937421;22012619;22118461;22179786;22277660;22988298;23065663;23186163;23391514;23622243;23709753;23840062;24027009;24554720;24662513;24715725;25418920;25429106;25561469;25712099;25892735;26768311;26811146;26992070;27435373;28063628;28218747;28228285;28411811;2842325;28494185;28510447;28832583;28834231;28904123;29175432;29242379;29437277;29557506;3004351;30315122;30410026;30484775;30653781;30833945;31217245;31844290;31998317;32157095;32357974;32387766;32488085;32938616;33298915;33592498;33691108;33717175;33912179;33968037;34171305;34357683;35051231;35189042;35561310;35580925;36010968;36215666;36284347;38654521;7661930;8072530;8128251;8505312;8805365;9063748;9099749;9294177;9419979;9428522;9430682;9469823;9677427;9822680;9882630",
        "class_list": "",
        "function": "Adenine nucleotides induce large asymmetric conformational changes in full-length human MutL alpha. These changes are associated with significant increases in secondary structure., [RefSeq, PubMed]; Component of the post-replicative DNA mismatch repair system (MMR) (PubMed:30653781, PubMed:35189042). Heterodimerizes with MLH1 to form MutL alpha. DNA repair is initiated by MutS alpha (MSH2-MSH6) or MutS beta (MSH2-MSH3) binding to a dsDNA mismatch, then MutL alpha is recruited to the heteroduplex. Assembly of the MutL-MutS-heteroduplex ternary complex in presence of RFC and PCNA is sufficient to activate endonuclease activity of PMS2. It introduces single-strand breaks near the mismatch and thus generates new entry points for the exonuclease EXO1 to degrade the strand containing the mismatch. DNA methylation would prevent cleavage and therefore assure that only the newly mutated DNA strand is going to be corrected. MutL alpha (MLH1-PMS2) interacts physically with the clamp loader subunits of DNA polymerase III, suggesting that it may play a role to recruit the DNA polymerase III to the site of the MMR. Also implicated in DNA damage signaling, a process which induces cell cycle arrest and can lead to apoptosis in case of major DNA damages. Possesses an ATPase activity, but in the absence of gross structural changes, ATP hydrolysis may not be necessary for proficient mismatch repair (PubMed:35189042)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; In vitro data suggest a role for PMS2 Kozak sequence mutations in Lynch syndrome risk., [RefSeq, PubMed]; The protein encoded by this gene is a key component of the mismatch repair system that functions to correct DNA mismatches and small insertions and deletions that can occur during DNA replication and homologous recombination. This protein forms heterodimers with the gene product of the mutL homolog 1 (MLH1) gene to form the MutL-alpha heterodimer. The MutL-alpha heterodimer possesses an endonucleolytic activity that is activated following recognition of mismatches and insertion/deletion loops by the MutS-alpha and MutS-beta heterodimers, and is necessary for removal of the mismatched DNA. There is a DQHA(X)2E(X)4E motif found at the C-terminus of the protein encoded by this gene that forms part of the active site of the nuclease. Mutations in this gene have been associated with hereditary nonpolyposis colorectal cancer (HNPCC; also known as Lynch syndrome) and Turcot syndrome. [provided by RefSeq, Apr 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R610;Q52LH6;Q5FBW9;Q5FBX1;Q5FBX2;Q75MR2",
        "ec_number_list": [
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "5.6.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
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            },
            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
                "type": "external"
            },
            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "3.1.13.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
                "type": "external"
            },
            {
                "id": "5.6.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
                "type": "external"
            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
                "type": "external"
            },
            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004519 endonuclease activity;GO:0032138 single base insertion or deletion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0032389 MutLalpha complex;GO:0032300 mismatch repair complex",
        "go_biological_process": "GO:0000710 meiotic mismatch repair;GO:0006298 mismatch repair;GO:0016446 somatic hypermutation of immunoglobulin genes;GO:0048304 positive regulation of isotype switching to IgG isotypes;GO:0048298 positive regulation of isotype switching to IgA isotypes",
        "synthesized_glycan_count": 0,
        "hit_score": 14.4,
        "record_id": "P54278-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96JG8-1",
        "uniprot_id": [
            {
                "id": "MAGD4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96JG8",
                "type": "external"
            }
        ],
        "mass": 81378.0,
        "length": 741,
        "protein_name": "Melanoma-associated antigen D4",
        "gene_name": "MAGED4B; MAGED4",
        "organism": "Human",
        "refseq_name": "melanoma-associated antigen D4 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001092270",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092270",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAGED4B; MAGED4; KIAA1859; MAGED4A; MAGEE1",
        "gene_names_refseq": "MAGE-D4; MAGE-E1; MAGE1; MAGED4",
        "protein_names_uniprotkb": "Melanoma-associated antigen D4; MAGE-D4 antigen; MAGE-E1 antigen",
        "protein_names_refseq": "MAGE-D4 antigen; MAGE-E1 antigen; melanoma antigen family D, 4; melanoma antigen family D4; melanoma-associated antigen D4 isoform 2; melanoma-associated antigen D4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:728239);  (hsa:81557)",
        "pathway_count": 2,
        "publication_count": 53,
        "publication_id_list": "11230166;11237011;11406556;11602350;16082191;20864041;23481700;24147998;24870746;25120768;25483651;25951896;26375851;26992070;27600516;27862975;28031124;28228285;28832583;28834231;29242379;29331515;29508533;29557506;29786170;30193086;30315122;30429286;30833945;31154438;31222486;31291378;31704827;31844290;31848261;31998317;32157095;32350084;32387766;32488085;32938616;32983136;33592498;33968037;34087483;34171305;34290406;34509645;34561969;35051231;35580925;36010968;36284347",
        "class_list": "",
        "function": "High MAGED4 expression is associated with Esophageal Squamous Cell Carcinoma., [RefSeq, PubMed]; MAGED4 (mRNA and protein) is frequently and highly expressed in glioma and is partly regulated by DNA methylation., [RefSeq, PubMed]; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex., [UniProtKB, PubMed]; Preoperative serum MAGED4 was significantly higher in esophageal squamous cell carcinoma patients than in controls., [RefSeq, PubMed]; Results suggest that MAGE-D4 overexpression influences tumor progression, and MADE-D4 can be a prognostic marker and a potential molecular target in squamous cell esophageal cancer., [RefSeq, PubMed]; The MAGE-D4 polyclonal antibody with high specificity and sensitivity has been successfully prepared., [RefSeq, PubMed]; These findings suggest MAGE-D4 may serve as a potentially prognostic biomarker and an attractive target of immunotherapy in colorectal cancer Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "reported_mutagensis": 0,
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        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K093;Q5HYN6;Q8WXW4;Q9BQ84;Q9BVH1;Q9BYH3;Q9BYH4;Q9H217",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q96JG8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75900-1",
        "uniprot_id": [
            {
                "id": "MMP23_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75900",
                "type": "external"
            }
        ],
        "mass": 43935.0,
        "length": 390,
        "protein_name": "Matrix metalloproteinase-23",
        "gene_name": "MMP23B",
        "organism": "Human",
        "refseq_name": "matrix metalloproteinase-23 precursor",
        "refseq_ac": [
            {
                "id": "NP_008914",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_008914",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MMP23B; MMP21; MMP22",
        "gene_names_refseq": "MIFR-1; MIFR; MMP22; MMP23B",
        "protein_names_uniprotkb": "Matrix metalloproteinase-23; 3.4.24.-; Femalysin; MIFR-1; MMP-21; MMP-22; MMP-23; Matrix metalloproteinase-21; Matrix metalloproteinase-22",
        "protein_names_refseq": "femalysin; matrix metalloproteinase 23B; matrix metalloproteinase in the female reproductive tract; matrix metalloproteinase-23 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8510)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "11237011;11328856;18669648;24715725;30052775;31092671;32897882;32938616;33968037;35051231;35251023;36241641;37217939;9740677;9988691",
        "class_list": "",
        "function": "Compares rat and human proteins, describes unique Type II membrane topology, and suggests a role in reproductive processes., [RefSeq, PubMed]; Protease. May regulate the surface expression of some potassium channels by retaining them in the endoplasmic reticulum (By similarity)., [UniProtKB]; There is evidence of MMP23B secretion in plasma and urine, suggesting a role of this poorly characterized metalloproteinase in urinary bladder cancer as a potential non-invasive biomarker for this cancer, [RefSeq, PubMed]; This gene (MMP23B) encodes a member of the matrix metalloproteinase (MMP) family, and it is part of a duplicated region of chromosome 1p36.3. Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. This gene belongs to the more telomeric copy of the duplicated region. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2AGN0;A2AGN1;O75894;O75895;Q5QPQ8;Q76P96;Q7LDM6;Q7LDM7;Q9UBR9;Q9UJK8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "O75900-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N7M0-1",
        "uniprot_id": [
            {
                "id": "DYLT5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N7M0",
                "type": "external"
            }
        ],
        "mass": 20730.0,
        "length": 179,
        "protein_name": "Dynein light chain Tctex-type 5",
        "gene_name": "DYNLT5",
        "organism": "Human",
        "refseq_name": "dynein light chain Tctex-type 5",
        "refseq_ac": [
            {
                "id": "NP_689878",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689878",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "DYNLT5; TCTEX1D1",
        "gene_names_refseq": "DYNLT5; TCTEX1D1",
        "protein_names_uniprotkb": "Dynein light chain Tctex-type 5; Tctex1 domain-containing protein 1",
        "protein_names_refseq": "Tctex1 domain containing 1; dynein light chain Tctex-type 5; tctex1 domain-containing protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:200132);  (R-HSA-5620924)",
        "pathway_count": 2,
        "publication_count": 60,
        "publication_id_list": "10069812;11237011;11285270;12795688;15231740;15269286;15489852;15523559;15955805;16049494;16435301;16492809;16775004;16782012;17312020;17314406;17574030;18180368;18304522;18364699;18369462;18852297;19112494;19147001;19253336;19384852;19450523;19720863;19805633;20435895;20526327;20526328;20530210;20889716;21427764;21936775;22118932;22922713;22992454;23945166;23990561;24140113;24296415;24596149;24616010;25205765;25349261;25443296;29557506;29601588;31896777;32387766;34509645;35051231;8516294;8522608;9114011;9585416;9585417;9852153",
        "class_list": "",
        "function": "TCTEX1D1 is a genetic modifier of disease progression in Duchenne muscular dystrophy., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q06YR9;Q5VYE1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0045505 dynein intermediate chain binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005868 cytoplasmic dynein complex",
        "go_biological_process": "GO:0007018 microtubule-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q8N7M0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6P1Q9-1",
        "uniprot_id": [
            {
                "id": "MET2B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P1Q9",
                "type": "external"
            }
        ],
        "mass": 43426.0,
        "length": 378,
        "protein_name": "tRNA N(3)-cytidine methyltransferase METTL2B",
        "gene_name": "METTL2B",
        "organism": "Human",
        "refseq_name": "tRNA N(3)-cytidine methyltransferase METTL2B",
        "refseq_ac": [
            {
                "id": "NP_060866",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060866",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL2B",
        "gene_names_refseq": "METL; METTL2B; METTL2; PSENIP1",
        "protein_names_uniprotkb": "tRNA N(3)-cytidine methyltransferase METTL2B; 2.1.1.-; Methyltransferase-like protein 2B",
        "protein_names_refseq": "methyltransferase 2B, methylcytidine; methyltransferase like 2B; methyltransferase-like protein 2B; tRNA N(3)-cytidine methyltransferase METTL2B; tRNA N(3)-methylcytidine methyltransferase METTL2B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55798)",
        "pathway_count": 1,
        "publication_count": 45,
        "publication_id_list": "11237011;18669648;19690332;20068231;21518805;23186163;23301498;24715725;25418920;26811146;26929215;27846572;28063628;28510447;28655767;28904123;29393594;29493099;29557506;29632046;29786170;30315122;31217245;31844290;32157095;32265295;32357974;32387766;32427860;32488085;32897882;32938616;33912179;33936100;33968037;33981976;34185709;34268557;34561969;34932366;35051231;35561310;35580925;36010968;36241641",
        "class_list": "",
        "function": "Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Thr)(UGU) and tRNA(Arg)(CCU)., [UniProtKB, PubMed]; This gene is a member of a family of methyltransferases that share homology with, but are distinct from, the UbiE family of methyltransferases. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DZ68;Q0IJ54;Q3B7J1",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016427 tRNA (cytidine) methyltransferase activity;GO:0052735 tRNA (cytidine-3-)-methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0008173 RNA methyltransferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006399 tRNA metabolic process;GO:0030488 tRNA methylation;GO:0008033 tRNA processing;GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q6P1Q9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15424-1",
        "uniprot_id": [
            {
                "id": "SAFB1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15424",
                "type": "external"
            }
        ],
        "mass": 102642.0,
        "length": 915,
        "protein_name": "Scaffold attachment factor B1",
        "gene_name": "SAFB",
        "organism": "Human",
        "refseq_name": "scaffold attachment factor B1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001188267",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001188267",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SAFB; HAP; HET; SAFB1",
        "gene_names_refseq": "HAP; HET; SAB-B1; SAF-B1; SAF-B; SAFB1; SAFB",
        "protein_names_uniprotkb": "Scaffold attachment factor B1; HSP27 ERE-TATA-binding protein; HSP27 estrogen response element-TATA box-binding protein; SAF-B1; SAF-B",
        "protein_names_refseq": "HSP27 ERE-TATA-binding protein; HSP27 estrogen response element-TATA box-binding protein; Hsp27 ERE-TATA binding protein; glutathione S-transferase fusion protein; heat-shock protein (HSP27) estrogen response element and TATA box-binding protein; scaffold attachment factor B1 isoform 1; scaffold attachment factor B1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6294);  (R-HSA-3899300)",
        "pathway_count": 2,
        "publication_count": 134,
        "publication_id_list": "11237011;11477070;11509566;11842083;12150977;12529333;12660241;12679040;12718889;15302935;15766567;15958389;15976810;16098147;16757475;16964243;17079232;17081983;17081986;17287340;17298944;17369852;17535915;17803295;17924679;17942393;18082607;18211901;18212344;18339323;18452278;18488044;18510355;18669648;18707149;19240082;19413330;19415658;19596686;19608861;19615980;19651622;19664994;19664995;19674106;19995069;20058876;20068231;20098713;20112406;20176810;20676127;21338522;21406692;21527249;22223895;22467880;22693546;22713328;23186163;23301498;23404503;23673342;24129315;24275569;24715725;25114211;25218447;25418920;25576301;25755297;25800734;26154972;26811146;26929215;26992070;27731383;27846572;27920218;28228285;28649982;28832583;28834231;28860189;28904123;29242379;29331515;29393594;29493099;29557506;29632046;29786170;30315122;30379171;30410026;30429286;30779550;31154438;31530632;31844290;31848261;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32938616;33214551;33298915;33592498;33633747;33912179;33968037;33981976;34019948;34087483;34129097;34171305;34561969;34932366;35051231;35251023;35318648;35580925;36241641;36427398;36462498;36577137;40914422;8600450;9328833;9671816",
        "class_list": "",
        "function": "Binds to scaffold/matrix attachment region (S/MAR) DNA and forms a molecular assembly point to allow the formation of a 'transcriptosomal' complex (consisting of SR proteins and RNA polymerase II) coupling transcription and RNA processing (PubMed:9671816). Functions as an estrogen receptor corepressor and can also bind to the HSP27 promoter and decrease its transcription (PubMed:12660241). Thereby acts as a negative regulator of cell proliferation (PubMed:12660241). When associated with RBMX, binds to and stimulates transcription from the SREBF1 promoter (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; HOXA9 forms a repressive complex with nuclear matrix-associated protein SAFB to maintain acute myeloid leukemia., [RefSeq, PubMed]; SKA1 promotes tumor metastasis via SAFB-mediated transcription repression of DUSP6 in clear cell renal cell carcinoma., [RefSeq, PubMed]; Short-term hypoxia triggers ROS and SAFB mediated nuclear matrix and mRNA splicing remodeling., [RefSeq, PubMed]; Subcellular dynamics of estrogen-related receptors involved in transrepression through interactions with scaffold attachment factor B1., [RefSeq, PubMed]; This gene encodes a DNA-binding protein which has high specificity for scaffold or matrix attachment region DNA elements (S/MAR DNA). This protein is thought to be involved in attaching the base of chromatin loops to the nuclear matrix but there is conflicting evidence as to whether this protein is a component of chromatin or a nuclear matrix protein. Scaffold attachment factors are a specific subset of nuclear matrix proteins (NMP) that specifically bind to S/MAR. The encoded protein is thought to serve as a molecular base to assemble a 'transcriptosome complex' in the vicinity of actively transcribed genes. It is involved in the regulation of heat shock protein 27 transcription, can act as an estrogen receptor co-repressor and is a candidate for breast tumorigenesis. This gene is arranged head-to-head with a similar gene whose product has the same functions. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Jan 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 51,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AV56;B7Z5B6;B7ZLP6;F5H0H3;O60406;Q59HH8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003723 RNA binding;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0030496 midbody",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006325 chromatin organization;GO:0030520 estrogen receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "Q15424-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P41217-1",
        "uniprot_id": [
            {
                "id": "OX2G_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P41217",
                "type": "external"
            }
        ],
        "mass": 31264.0,
        "length": 278,
        "protein_name": "OX-2 membrane glycoprotein",
        "gene_name": "CD200",
        "organism": "Human",
        "refseq_name": "OX-2 membrane glycoprotein isoform d",
        "refseq_ac": [
            {
                "id": "NP_001305757",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305757",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CD200; MOX1; MOX2; My033",
        "gene_names_refseq": "CD200; MOX1; MOX2; MRC; OX-2",
        "protein_names_uniprotkb": "OX-2 membrane glycoprotein",
        "protein_names_refseq": "CD200 antigen; OX-2 membrane glycoprotein isoform d; OX-2 membrane glycoprotein; antigen identified by monoclonal antibody MRC OX-2",
        "tax_id": 9606,
        "disease": "autoimmune disease (Disease Ontology:DOID:417)",
        "pathway": " (hsa:4345);  (R-HSA-198933)",
        "pathway_count": 2,
        "publication_count": 98,
        "publication_id_list": "10499918;10746781;11237011;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12213321;12483297;12588680;14719373;14970179;15034010;15136729;15155468;15187158;15304001;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;15955564;16014749;16091383;16129954;16303743;16339513;16380601;16551255;16737824;16754721;16893496;16904340;16928187;17045824;17057721;17237375;17337780;18031695;18037897;18055229;18209062;18234675;18593354;19149696;19359216;19592130;20730098;21241660;21800138;21841309;21877119;22396535;23695528;23929856;24190977;24305946;25502872;25703557;25716998;26284469;26300885;27600516;27920218;29632711;3032785;31844290;32157095;32350084;33936100;35051231;35154160;35580925;37616575;37801139;37894750;38455039;38619621;7531291;7542404;8178173;8995416;9285412;9314561;9700512;9730896",
        "class_list": "",
        "function": "CD200 genotype is associated with clinical outcome of patients with multiple myeloma. Publication Status: Online-Only, [RefSeq, PubMed]; CD200 is overexpressed in the pancreatic tumor microenvironment and predictive of overall survival. Publication Status: Online-Only, [RefSeq, PubMed]; Costimulates T-cell proliferation. May regulate myeloid cell activity in a variety of tissues., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Emerging Immune Checkpoint Molecules on Cancer Cells: CD24 and CD200. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy., [RefSeq, PubMed]; Integrating TSPO PET imaging and transcriptomics to unveil the role of neuroinflammation and amyloid-beta deposition in Alzheimer's disease., [RefSeq, PubMed]; Revealed a 169 bp region responsible for constitutive expression of CD200; positive regulatory domains were identified in the core promoter; and documented evidence for C/EBPbeta as being important in transcriptional regulation of CD200, [RefSeq, PubMed]; This gene encodes a type I membrane glycoprotein containing two extracellular immunoglobulin domains, a transmembrane and a cytoplasmic domain. This gene is expressed by various cell types, including B cells, a subset of T cells, thymocytes, endothelial cells, and neurons. The encoded protein plays an important role in immunosuppression and regulation of anti-tumor activity. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jan 2016]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KQI1;B4DLW9;D3DN65;Q6J2Q6;Q6PIQ4;Q8TB85;Q9H3J3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity;GO:0086080 protein binding involved in heterotypic cell-cell adhesion;GO:0140081 glycosylated region protein binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0030424 axon;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0043032 positive regulation of macrophage activation;GO:1904465 negative regulation of matrix metallopeptidase secretion;GO:0002695 negative regulation of leukocyte activation;GO:1905522 negative regulation of macrophage migration;GO:0008285 negative regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.3,
        "record_id": "P41217-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6Q8B3-1",
        "uniprot_id": [
            {
                "id": "MO2R2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6Q8B3",
                "type": "external"
            }
        ],
        "mass": 29920.0,
        "length": 271,
        "protein_name": "Cell surface glycoprotein CD200 receptor 2",
        "gene_name": "CD200R1L",
        "organism": "Human",
        "refseq_name": "cell surface glycoprotein CD200 receptor 2 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001008784",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008784",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CD200R1L; CD200R2",
        "gene_names_refseq": "CD200R1L; CD200R2; CD200RLa",
        "protein_names_uniprotkb": "Cell surface glycoprotein CD200 receptor 2; CD200 cell surface glycoprotein receptor-like 2; CD200 cell surface glycoprotein receptor-like a; CD200 receptor-like 2; CD200RLa; Cell surface glycoprotein CD200 receptor 1-like; Cell surface glycoprotein OX2 receptor 2; HuCD200R2",
        "protein_names_refseq": "CD200 cell surface glycoprotein receptor 2; CD200 cell surface glycoprotein receptor-like 2; CD200 cell surface glycoprotein receptor-like a; CD200 receptor 2; CD200 receptor-like 2; cell surface glycoprotein CD200 receptor 1-like; cell surface glycoprotein CD200 receptor 2 isoform 1 precursor; cell surface glycoprotein CD200 receptor 2; cell surface glycoprotein OX2 receptor 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:344807)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;12960329;15274657;29557506;35051231",
        "class_list": "",
        "function": "May be a receptor for the CD200/OX2 cell surface glycoprotein., [UniProtKB]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6WHB7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0150077 regulation of neuroinflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q6Q8B3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BQP7-1",
        "uniprot_id": [
            {
                "id": "MGME1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BQP7",
                "type": "external"
            }
        ],
        "mass": 39421.0,
        "length": 344,
        "protein_name": "Mitochondrial genome maintenance exonuclease 1",
        "gene_name": "MGME1",
        "organism": "Human",
        "refseq_name": "mitochondrial genome maintenance exonuclease 1 isoform 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_001297268",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297268",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MGME1; C20orf72; DDK1",
        "gene_names_refseq": "C20orf72; DDK1; MGME1; MTDPS11; bA504H3.4",
        "protein_names_uniprotkb": "Mitochondrial genome maintenance exonuclease 1; 3.1.-.-",
        "protein_names_refseq": "mitochondrial genome maintenance exonuclease 1 isoform 3 precursor",
        "tax_id": 9606,
        "disease": "mitochondrial DNA depletion syndrome 11 (Disease Ontology:DOID:0080129)",
        "pathway": " (hsa:92667);  (R-HSA-9913635)",
        "pathway_count": 2,
        "publication_count": 69,
        "publication_id_list": "10497183;10608893;10677218;11237011;15167897;18187503;18669648;18685103;19413330;19664994;19837034;20068231;20445207;20877624;21953457;22383523;23313956;23358826;25635099;25645385;26253742;26375851;26992070;27220468;27226550;27920218;28228285;28514659;28832583;28834231;28904123;29242379;29290614;29557506;29572490;29786170;30102370;30247721;30256971;30315122;30605451;30949702;31154438;31844290;32157095;32161166;32357974;32488085;32938616;33298915;33847964;33912179;33968037;34171305;34185709;34561969;34932366;35132862;35561310;35580925;35819194;35947649;36010968;36528058;36744436;37013609;37166417;37592734;37938771",
        "class_list": "",
        "function": "Besides the conserved two-cation-assisted catalytic mechanism, structural analysis of HsMGME1 and comparison with homologous proteins also clarified substrate binding and cleavage directionalities of the DNA double-strand break repair complexes RecBCD and AddAB., [RefSeq, PubMed]; Loss-of-function mutations in MGME1 impair mtDNA replication and cause multisystemic mitochondrial disease., [RefSeq, PubMed]; MGME1 associates with poor prognosis and is vital for cell proliferation in lower-grade glioma., [RefSeq, PubMed]; MGME1 is part of a termination complex acting at the end of the D-loop region where it modulates mtDNA replication and H-strand transcription termination Publication Status: Online-Only, [RefSeq, PubMed]; Metal-dependent single-stranded DNA (ssDNA) exonuclease involved in mitochondrial genome maintenance. Has preference for 5'-3' exonuclease activity but is also capable of endoduclease activity on linear substrates. Necessary for maintenance of proper 7S DNA levels. Probably involved in mitochondrial DNA (mtDNA) repair, possibly via the processing of displaced DNA containing Okazaki fragments during RNA-primed DNA synthesis on the lagging strand or via processing of DNA flaps during long-patch base excision repair., [UniProtKB, HAMAP, UniProtKB, UniProtKB, PubMed, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Overexperssion of Ddk1 decreases the levels of 7S DNA, suggesting an important role of the protein in 7S DNA regulation., [RefSeq, PubMed]; The protein encoded by this gene is a nuclear-encoded mitochondrial protein necessary for the maintenance of mitochondrial genome synthesis. The encoded protein is a RecB-type exonuclease and primarily cleaves single-stranded DNA. Defects in this gene have been associated with mitochondrial DNA depletion syndrome-11. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDG5;D3DW29;Q96SW3",
        "ec_number_list": [
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0045145 single-stranded DNA 5'-3' DNA exonuclease activity;GO:0017108 5'-flap endonuclease activity;GO:0008297 single-stranded DNA exodeoxyribonuclease activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006264 mitochondrial DNA replication;GO:0043504 mitochondrial DNA repair",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q9BQP7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TCB7-1",
        "uniprot_id": [
            {
                "id": "METL6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TCB7",
                "type": "external"
            }
        ],
        "mass": 33251.0,
        "length": 284,
        "protein_name": "tRNA N(3)-cytidine methyltransferase METTL6",
        "gene_name": "METTL6",
        "organism": "Human",
        "refseq_name": "tRNA N(3)-cytidine methyltransferase METTL6 isoform 4",
        "refseq_ac": [
            {
                "id": "NP_001288721",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288721",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL6",
        "gene_names_refseq": "METTL6; hMETTL6",
        "protein_names_uniprotkb": "tRNA N(3)-cytidine methyltransferase METTL6; 2.1.1.-; Methyltransferase-like protein 6; hMETTL6",
        "protein_names_refseq": "methyltransferase 6, RNA N3-cytidine; methyltransferase 6, methylcytidine; methyltransferase like 6; methyltransferase-like protein 6; tRNA N(3)-cytidine methyltransferase METTL6 isoform 4; tRNA N(3)-cytidine methyltransferase METTL6; tRNA N(3)-methylcytidine methyltransferase METTL6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:131965)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;25576301;27920218;28655767;28832583;29632046;30484775;30524438;31530632;31844290;32157095;32265295;32502341;32923617;32938616;33592498;33717175;33912179;33968037;33981976;34268557;34862464;34922197",
        "class_list": "",
        "function": "Crystal structure of human METTL6, the m(3)C methyltransferase. Publication Status: Online-Only, [RefSeq, PubMed]; Data, including data from studies using mutant/knockout mice and cell lines from such mice, suggest that METTL2 and METTL6 (but not METTL8) contribute to post-transcriptional methylation of cytidine (formation of 3-methylcytidine) in tRNA; METTL2 methylates tRNA(Thr) and tRNA(Arg); METTL6 interacts with seryl-tRNA synthetase and methylates tRNA(Ser); METTL8 catalyzes post-transcriptional methylation of cytidine in mRNA., [RefSeq, PubMed]; METTL6 is a tRNA m(3)C methyltransferase that regulates pluripotency and tumor cell growth. Publication Status: Online-Only, [RefSeq, PubMed]; Mutually exclusive substrate selection strategy by human m3C RNA transferases METTL2A and METTL6., [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent methyltransferase that mediates N(3)-methylcytidine modification of residue 32 of the tRNA anticodon loop of tRNA(Ser), including tRNA(Ser)(UGA) and tRNA(Ser)(GCU) (PubMed:32923617, PubMed:34268557, PubMed:34862464, PubMed:34922197). Interaction with SARS1/SerRS is required for N(3)-methylcytidine methylation (PubMed:34268557)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Structural basis for METTL6-mediated m3C RNA methylation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96LU4",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0052735 tRNA (cytidine-3-)-methyltransferase activity;GO:0008757 S-adenosylmethionine-dependent methyltransferase activity;GO:0008173 RNA methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006400 tRNA modification;GO:0030488 tRNA methylation;GO:0106217 tRNA C3-cytosine methylation;GO:0008033 tRNA processing;GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q8TCB7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86VX9-1",
        "uniprot_id": [
            {
                "id": "MON1A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86VX9",
                "type": "external"
            }
        ],
        "mass": 72895.0,
        "length": 652,
        "protein_name": "Vacuolar fusion protein MON1 homolog A",
        "gene_name": "MON1A",
        "organism": "Human",
        "refseq_name": "vacuolar fusion protein MON1 homolog A isoform b",
        "refseq_ac": [
            {
                "id": "NP_001135973",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135973",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MON1A; SAND1",
        "gene_names_refseq": "MON1A; SAND1",
        "protein_names_uniprotkb": "Vacuolar fusion protein MON1 homolog A",
        "protein_names_refseq": "MON1 homolog A, secretory trafficking associated; MON1 secretory trafficking family member A; vacuolar fusion protein MON1 homolog A isoform b; vacuolar fusion protein MON1 homolog A",
        "tax_id": 9606,
        "disease": "congenital diarrhea (Disease Ontology:DOID:0060774)",
        "pathway": " (hsa:84315);  (R-HSA-8876198)",
        "pathway_count": 2,
        "publication_count": 202,
        "publication_id_list": "10818110;10990452;11038176;11179213;11237011;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18354496;18367545;1845915;18477474;18559336;18585354;18664496;18669648;18701652;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19620288;19656848;19725050;19729655;19745841;20008558;20154091;20159109;20159556;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22665492;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23186163;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23645161;23678941;23684622;23713133;23839779;24296415;24644286;24694596;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25472813;25648148;25713415;25892735;25925668;26055712;26177209;26245486;26434594;26538022;26925400;26936971;27041585;27044746;27103185;27246931;27329675;29393594;29632046;29769354;30379171;31154438;31324691;31844290;32161166;32983136;33592498;33912179;34357683;34432599;34561969;37217939;40174224;7688123;7911226;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "A role for Mon1a in anterograde trafficking through the secretory apparatus., [RefSeq, PubMed]; Plays an important role in membrane trafficking through the secretory apparatus., [UniProtKB, UniProtKB]; Plays an important role in membrane trafficking through the secretory apparatus. Not involved in endocytic trafficking to lysosomes (By similarity). Acts in concert with CCZ1, as a guanine exchange factor (GEF) for RAB7, promotes the exchange of GDP to GTP, converting it from an inactive GDP-bound form into an active GTP-bound form (PubMed:23084991)., [UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDQ1;G5E9N1;Q8NAV7;Q9BRF3;X6R3V9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0035658 Mon1-Ccz1 complex",
        "go_biological_process": "GO:0016192 vesicle-mediated transport;GO:0009306 protein secretion;GO:0006623 protein targeting to vacuole",
        "synthesized_glycan_count": 0,
        "hit_score": 20.5,
        "record_id": "Q86VX9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NQG1-1",
        "uniprot_id": [
            {
                "id": "MANBL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NQG1",
                "type": "external"
            }
        ],
        "mass": 9467.0,
        "length": 85,
        "protein_name": "Protein MANBAL",
        "gene_name": "MANBAL",
        "organism": "Human",
        "refseq_name": "protein MANBAL isoform a",
        "refseq_ac": [
            {
                "id": "NP_001003897",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001003897",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MANBAL",
        "gene_names_refseq": "MANBAL",
        "protein_names_uniprotkb": "Protein MANBAL",
        "protein_names_refseq": "mannosidase beta A like; mannosidase, beta A, lysosomal-like; protein MANBAL isoform a; protein MANBAL",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:63905)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;25576301;28228285;29393594;29557506;30429286;31154438;31844290;31848261;32938616;33592498;33968037;35580925",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KAA6;E1P5V3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q9NQG1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q685J3-1",
        "uniprot_id": [
            {
                "id": "MUC17_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q685J3",
                "type": "external"
            }
        ],
        "mass": 451741.0,
        "length": 4493,
        "protein_name": "Mucin-17",
        "gene_name": "MUC17",
        "organism": "Human",
        "refseq_name": "mucin-17 precursor",
        "refseq_ac": [
            {
                "id": "NP_001035194",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035194",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MUC17; MUC3",
        "gene_names_refseq": "MUC-17; MUC-3; MUC17; MUC3",
        "protein_names_uniprotkb": "Mucin-17; MUC-17; MUC-3; Small intestinal mucin-3",
        "protein_names_refseq": "membrane mucin MUC17; mucin-17 precursor; secreted mucin MUC17; small intestinal mucin MUC3; small intestinal mucin-3",
        "tax_id": 9606,
        "disease": "colitis (Disease Ontology:DOID:0060180); otitis media (Disease Ontology:DOID:10754); liver cirrhosis (Disease Ontology:DOID:5082); cholangitis (Disease Ontology:DOID:9446)",
        "pathway": " (hsa:140453);  (R-HSA-5083625);  (R-HSA-5083632);  (R-HSA-5083636);  (R-HSA-5621480);  (R-HSA-913709);  (R-HSA-977068)",
        "pathway_count": 7,
        "publication_count": 84,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10330415;10430883;10504389;10742600;10753916;11042166;11062056;11110698;11237011;11283017;11304796;11606584;11821425;11855812;12464682;12855678;12888891;1329093;14656219;15466199;15486459;15560372;15599692;15620693;15687324;16151858;16251947;16319059;16737958;17050534;17113861;17990980;18490740;18537974;18776906;18818202;19617566;21880719;22041900;22183981;22461326;23053572;23507963;23584533;23602766;2373995;24643043;24715725;25153226;25813380;26758079;29557506;31154438;31262330;31387973;31530632;31844290;32387766;32488085;32938616;33912179;34087483;35051231;35580925;36010968;36215666;36778111;37562166;7655172;8333853;8598452;8611500;8920913;8972730;9042338;9295285;9299468;9394011;9417100;9435216;9915862;9988682",
        "class_list": "",
        "function": "Acquired resistance to EGFR-TKIs in NSCLC mediates epigenetic downregulation of MUC17 by facilitating NF-kappaB activity via UHRF1/DNMT1 complex. Publication Status: Online-Only, [RefSeq, PubMed]; MUC17 inactivated NFkappaB to inhibit gastric cancer cell proliferation in response to pro-inflammatory cytokines. The MUC17 function was dependent on its conserved epidermal growth factor domain and on downstream sequences to enable its interaction with myosin-9, resulting in a regulatory feedback loop between myosin-9, p53, and RhoA, and then activation of p38 to negatively regulate the NFkappaB pathway in gastric ca... Publication Status: Online-Only, [RefSeq, PubMed]; MUC17 mutations and methylation are associated with poor prognosis in adult-type diffuse glioma patients., [RefSeq, PubMed]; Overexpression and increased presentation at the plasma membrane of wild-type MUC17 and its phosphodeficient variant MUC17 S-4492A protected Caco-2 cells against adhesion of enteropathogenic Escherichia coli, indicating that C-terminal phosphorylation of MUC17 may play a functional role in epithelial cell protection. Publication Status: Online-Only, [RefSeq, PubMed]; Probably plays a role in maintaining homeostasis on mucosal surfaces., [UniProtKB, PubMed]; Sequence homology & chromosome mapping, [RefSeq, PubMed]; Surface localization of the smaller subunit of MUC17 is dependent on its N-glycosylation status, [RefSeq, PubMed]; The protein encoded by this gene is a membrane-bound mucin that provides protection to gut epithelial cells. The encoded protein contains about 60 tandem repeats, with each repeat being around 60 aa. N-glycosylation enables the encoded protein to localize on the cell surface, while the C-terminus interacts with the scaffold protein PDZ domain containing 1 (PDZK1). Two transcript variants, one protein-coding and the other non-protein coding, have been found for this gene. [provided by RefSeq, Nov 2015]., [RefSeq]",
        "predicted_glycosites": 26,
        "predicted_n_glycosites": 13,
        "predicted_o_glycosites": 13,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 420,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 32,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O14761;Q685J2;Q8TDH7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030165 PDZ domain binding;GO:0030197 extracellular matrix constituent, lubricant activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0019725 cellular homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 9.2,
        "record_id": "Q685J3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.001000.000000000001000000.0100000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "H3BPM6-1",
        "uniprot_id": [
            {
                "id": "MKROS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/H3BPM6",
                "type": "external"
            }
        ],
        "mass": 25451.0,
        "length": 223,
        "protein_name": "MKRN2 opposite strand protein",
        "gene_name": "MKRN2OS",
        "organism": "Human",
        "refseq_name": "MKRN2 opposite strand protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001182208",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182208",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MKRN2OS; C3orf83; MKRN2-AS1",
        "gene_names_refseq": "C3orf83; MKRN2-AS1; MKRN2OS",
        "protein_names_uniprotkb": "MKRN2 opposite strand protein; MKRN2 antisense RNA 1; MKRN2 antisense gene protein 1",
        "protein_names_refseq": "MKRN2 antisense RNA 1 (non-protein coding); MKRN2 antisense gene protein 1; MKRN2 opposite strand protein isoform 1; MKRN2 opposite strand protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100129480)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "predicted_o_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "H3BPM6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86YR7-1",
        "uniprot_id": [
            {
                "id": "MF2L2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86YR7",
                "type": "external"
            }
        ],
        "mass": 126993.0,
        "length": 1114,
        "protein_name": "Probable guanine nucleotide exchange factor MCF2L2",
        "gene_name": "MCF2L2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "MCF2L2; ARHGEF22; DRG; KIAA0861",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Probable guanine nucleotide exchange factor MCF2L2; Dbs-related Rho family guanine nucleotide exchange factor; MCF2-transforming sequence-like protein 2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:23101)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "11237011;16959974;18259684;23481700;24715725;27397612;27600516;28832583;29557506;32157095;32387766;32897882;34171305;34433824;34561969;35051231;36284347",
        "class_list": "",
        "function": "Probably functions as a guanine nucleotide exchange factor., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O94942;Q6P2B8;Q6ZVJ5;Q8N318",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q86YR7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5EB52-1",
        "uniprot_id": [
            {
                "id": "MEST_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5EB52",
                "type": "external"
            }
        ],
        "mass": 38830.0,
        "length": 335,
        "protein_name": "Mesoderm-specific transcript homolog protein",
        "gene_name": "MEST",
        "organism": "Human",
        "refseq_name": "mesoderm-specific transcript homolog protein isoform c",
        "refseq_ac": [
            {
                "id": "NP_001240829",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001240829",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MEST; PEG1",
        "gene_names_refseq": "MEST; PEG1",
        "protein_names_uniprotkb": "Mesoderm-specific transcript homolog protein; 3.-.-.-; Paternally-expressed gene 1 protein",
        "protein_names_refseq": "mesoderm-specific transcript homolog protein isoform c; paternally-expressed gene 1 protein",
        "tax_id": 9606,
        "disease": "Barth syndrome (Disease Ontology:DOID:0050476)",
        "pathway": " (hsa:4232)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "10631159;11237011;16338457;25880248;26992070;27862975;28904123;29557506;31154438;31844290;31848261;32357974;32938616;33298915;33592498;33981976;35051231;36284347;37149929;37798282;37938771;38665916;39181599;8884280;9158153;9192843",
        "class_list": "",
        "function": "Alpha1,3-fucosylation of MEST promotes invasion potential of cytotrophoblast cells by activating translation initiation. Publication Status: Online-Only, [RefSeq, PubMed]; Genome-wide CRISPR/Cas9 screening identifies a targetable MEST-PURA interaction in cancer metastasis., [RefSeq, PubMed]; MEST gene is imprinted in an isoform-specific manner in adult lymphocytes., [RefSeq, PubMed]; MEST gene is imprinted, with preferential expression from the paternal allele in fetal tissues., [RefSeq, PubMed]; MEST promotes immune escape in gastric cancer by downregulating MHCI expression via SHP2., [RefSeq, PubMed]; PEG1 isoform 2 is in fact imprinted in a large subset of human placentae., [RefSeq, PubMed]; Plays an important role in enabling neurons to transition from bipolar to multipolar shapes, a process essential for their correct migration toward the cortical plate during brain development. This function is likely achieved through the regulation of N-cadherin-dependent cell adhesion and the modulation of Akt and canonical Wnt signaling pathways. Essential for the development and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. Negatively regulates the canonical Wnt signaling pathway during adipogenic differentiation by reducing the glycosylation, maturation, and cell membrane localization of the Wnt coreceptor LRP6., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of the alpha/beta hydrolase superfamily. It is imprinted, exhibiting preferential expression from the paternal allele in fetal tissues, and isoform-specific imprinting in lymphocytes. The loss of imprinting of this gene has been linked to certain types of cancer and may be due to promotor switching. The encoded protein may play a role in development. Alternatively spliced transcript variants encoding multiple isoforms have been identified for this gene. Pseudogenes of this gene are located on the short arm of chromosomes 3 and 4, and the long arm of chromosomes 6 and 15. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "glyco_site_count": 1,
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        "secondary_ac_list": "B2R6S1;O14973;O15007;Q6AI49;Q92571",
        "ec_number_list": [],
        "go_molecular_function": "GO:0016787 hydrolase activity;GO:0003824 catalytic activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0070062 extracellular exosome;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0032526 response to retinoic acid;GO:0045444 fat cell differentiation;GO:1903077 negative regulation of protein localization to plasma membrane;GO:0010883 regulation of lipid storage",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q5EB52-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95255-1",
        "uniprot_id": [
            {
                "id": "MRP6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95255",
                "type": "external"
            }
        ],
        "mass": 164906.0,
        "length": 1503,
        "protein_name": "ATP-binding cassette sub-family C member 6",
        "gene_name": "ABCC6",
        "organism": "Human",
        "refseq_name": "URG7 protein isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001072996",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072996",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ABCC6; ARA; MRP6",
        "gene_names_refseq": "ABC34; ABCC6; ARA; EST349056; GACI2; MLP1; MOAT-E; MOATE; MRP6; PXE1; PXE; URG7",
        "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 6; 7.6.2.-; 7.6.2.3; Anthracycline resistance-associated protein; MOAT-E; Multi-specific organic anion transporter E; Multidrug resistance-associated protein 6",
        "protein_names_refseq": "ATP-binding cassette, sub-family C (CFTR/MRP), member 6; URG7 protein isoform 2; anthracycline resistance-associated protein; multi-specific organic anion transporter E; multidrug resistance-associated protein 6",
        "tax_id": 9606,
        "disease": "arterial calcification of infancy (Disease Ontology:DOID:0050644); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); coronary artery disease (Disease Ontology:DOID:3393)",
        "pathway": " (hsa:368);  (R-HSA-382556);  (R-HSA-5690338)",
        "pathway_count": 3,
        "publication_count": 117,
        "publication_id_list": "10424734;10484077;10665657;10748049;10811882;10835642;10913334;10954200;11058917;11237011;11427982;11431746;11504826;11536079;11562789;11702217;11776382;11812794;11880368;12379217;12379510;12403779;12414644;12604685;12714611;12901863;1352877;1356264;1359686;1377674;14661924;15086542;15098239;15175422;15459974;15472518;15863492;15899824;16086317;16816140;16901789;17523162;17617515;17855752;17894550;17924679;17977821;18282684;18434309;18987736;19002207;19339160;19447222;19570978;1968359;19862647;1998343;20034067;20166139;20583968;20621639;21318057;22178883;22209248;23063411;23625951;23912081;24019521;24275569;24277820;24685677;24715725;2475911;24969777;25133187;25615550;25645385;2570070;26208431;26992070;27862975;28132103;28834231;2898143;29242379;29557506;30154241;30429286;31844290;32387766;32938616;32981041;33159684;33592498;33968037;34087483;34509645;3457471;3472246;35051231;35307651;35580925;36497052;37217939;38256207;38944164;39531497;39894887;7523390;7529176;7553863;7553864;7865904;9652413;9816258;9831708;9892204",
        "class_list": "",
        "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds, and xenobiotics from cells. Mediates ATP-dependent transport of glutathione conjugates such as leukotriene-c4 (LTC4) and N-ethylmaleimide S-glutathione (NEM-GS) (in vitro), and an anionic cyclopentapeptide endothelin antagonist, BQ-123 (PubMed:11880368, PubMed:12414644). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Does not appear to actively transport drugs outside the cell. Confers low levels of cellular resistance to etoposide, teniposide, anthracyclines and cisplatin (PubMed:12414644)., [UniProtKB, PubMed, PubMed, PubMed]; CircZXDC Promotes Vascular Smooth Muscle Cell Transdifferentiation via Regulating miRNA-125a-3p/ABCC6 in Moyamoya Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Inhibits TNF-mediated apoptosis through blocking one or more caspases., [UniProtKB, PubMed]; Mediates the release of nucleoside triphosphates, predominantly ATP, into the circulation, where it is rapidly converted into AMP and the mineralization inhibitor inorganic pyrophosphate (PPi) by the ecto-enzyme ectonucleotide pyrophosphatase phosphodiesterase 1 (ENPP1), therefore playing a role in PPi homeostasis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; The 75-99 C-Terminal Peptide of URG7 Protein Promotes alpha-Synuclein Disaggregation. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). The encoded protein, a member of the MRP subfamily, is involved in multi-drug resistance. Mutations in this gene cause pseudoxanthoma elasticum. Alternatively spliced transcript variants that encode different proteins have been described for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Vascular calcification in chronic kidney disease associated with pathogenic variants in ABCC6., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RRN8;A8KIG6;A8Y988;E7ESW8;P78420;Q8TCY8;Q9UMZ7",
        "ec_number_list": [
            {
                "id": "7.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2",
                "type": "external"
            },
            {
                "id": "7.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-",
                "type": "external"
            },
            {
                "id": "7.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0016887 ATP hydrolysis activity;GO:0015431 ABC-type glutathione S-conjugate transporter activity;GO:0140359 ABC-type transporter activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0005789 endoplasmic reticulum membrane;GO:0009925 basal plasma membrane",
        "go_biological_process": "GO:1904383 response to sodium phosphate;GO:0055085 transmembrane transport;GO:0007601 visual perception;GO:0009410 response to xenobiotic stimulus;GO:0055062 phosphate ion homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 12.3,
        "record_id": "O95255-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100100000001.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15286-1",
        "uniprot_id": [
            {
                "id": "RAB35_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15286",
                "type": "external"
            }
        ],
        "mass": 23025.0,
        "length": 201,
        "protein_name": "Ras-related protein Rab-35",
        "gene_name": "RAB35",
        "organism": "Human",
        "refseq_name": "ras-related protein Rab-35 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001161078",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161078",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAB35; RAB1C; RAY",
        "gene_names_refseq": "H-ray; RAB1C; RAB35; RAY",
        "protein_names_uniprotkb": "Ras-related protein Rab-35; 3.6.5.2; GTP-binding protein RAY; Ras-related protein Rab-1C",
        "protein_names_refseq": "GTP-binding protein RAY; ras-related protein Rab-35 isoform 2; ras-related protein Rab-35; ras-related protein rab-1c (GTP-binding protein ray)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11021);  (R-HSA-8854214);  (R-HSA-8873719);  (R-HSA-8876198)",
        "pathway_count": 4,
        "publication_count": 275,
        "publication_id_list": "10202141;10818110;10990452;11038176;11141079;11179213;11237011;11389151;11447212;11516400;11675392;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16055087;16207721;16373702;16395330;16401880;16410077;1648736;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17081065;17114793;17132146;17189207;17208202;17239822;17287728;17411337;17488286;17562788;17574030;17646400;17658474;17671165;17678623;17901050;18076383;18094055;18199687;18319245;18354496;18367545;1845915;18466115;18477474;18532927;18559336;18578522;18585354;18664496;18701652;18779367;18804435;1900457;19109890;19345684;19403694;19490898;19603039;19620288;19656848;19725050;19729655;19745841;20008558;20095038;20116244;20154091;20159109;20159556;20305638;20308558;20363736;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21383079;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21822290;21951725;22013193;22065758;22072793;22171327;22219378;22307087;22365832;22433857;22511774;22581368;22595670;22613832;22622570;22648168;22653444;22694141;22705394;22762500;22795129;22854040;22908308;22983554;23019362;23084991;23091056;23147242;23176487;23176493;23186163;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23481700;23562278;23645161;23678941;23684622;23713133;23839779;24023390;24296415;24644286;24694596;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25418920;25472813;25502872;25576301;25648148;25713415;25925668;26055712;26177209;26245486;26434594;26538022;26925400;26936971;26969162;26992070;27041585;27044746;27103185;27246931;27329675;28228285;28230050;28510447;28832583;28834231;29125462;29242379;29393594;29493099;29557506;29632711;29781368;29786170;29789417;30315122;30429286;30905672;31844290;31848261;32157095;32161166;32350084;32897882;32938616;32983136;33043033;33592498;33633747;33717175;33912179;33968037;34078123;34357683;34932366;35051231;35154160;35251023;35580925;36241641;37875118;38432637;38841112;7688123;7811277;7911226;7957092;7991565;8144603;8164745;8349690;8375503;8408203;8513495;8522602;8631982;8662963;8836150;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "A neurodevelopmental disorder associated with a loss-of-function missense mutation in RAB35., [RefSeq, PubMed]; Coxiella burnetii-containing vacuoles interact with host recycling endosomal proteins Rab11a and Rab35 for vacuolar expansion and bacterial growth. Publication Status: Online-Only, [RefSeq, PubMed]; The role of the oncogenic Rab35 in cancer invasion, metastasis, and immune evasion, especially in leukemia. Review article, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:30905672). RAB35 is involved in the process of endocytosis and is an essential rate-limiting regulator of the fast recycling pathway back to the plasma membrane (PubMed:21951725). During cytokinesis, required for the postfurrowing terminal steps, namely for intercellular bridge stability and abscission, possibly by controlling phosphatidylinositol 4,5-bis phosphate (PIP2) and SEPT2 localization at the intercellular bridge (PubMed:16950109). May indirectly regulate neurite outgrowth. Together with TBC1D13 may be involved in regulation of insulin-induced glucose transporter SLC2A4/GLUT4 translocation to the plasma membrane in adipocytes (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; This reference shows that MiniBAR/GARRE1 is a dual Rab35 and Rac1 effector during ciliogenesis., [RefSeq, PubMed]; This reference shows that the oxidoreductase MICAL1 is an effector of Rab35 during cytokinesis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 16,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6E0;B4E390",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.5.1.60",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.60",
                "type": "external"
            },
            {
                "id": "3.6.5.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.4",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0046872 metal ion binding;GO:0019003 GDP binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0070062 extracellular exosome;GO:0030669 clathrin-coated endocytic vesicle membrane",
        "go_biological_process": "GO:0015031 protein transport;GO:0031175 neuron projection development;GO:1990090 cellular response to nerve growth factor stimulus;GO:0016197 endosomal transport;GO:0036010 protein localization to endosome",
        "synthesized_glycan_count": 0,
        "hit_score": 27.8,
        "record_id": "Q15286-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q10571-1",
        "uniprot_id": [
            {
                "id": "MN1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q10571",
                "type": "external"
            }
        ],
        "mass": 136001.0,
        "length": 1320,
        "protein_name": "Transcriptional activator MN1",
        "gene_name": "MN1",
        "organism": "Human",
        "refseq_name": "transcriptional activator MN1",
        "refseq_ac": [
            {
                "id": "NP_002421",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002421",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MN1",
        "gene_names_refseq": "CEBALID; MGCR1-PEN; MGCR1; MGCR; MN1; dJ353E16.2",
        "protein_names_uniprotkb": "Transcriptional activator MN1; Probable tumor suppressor protein MN1",
        "protein_names_refseq": "meningioma (disrupted in balanced translocation) 1; meningioma (translocation balanced); meningioma chromosome region 1; probable tumor suppressor protein MN1; transcriptional activator MN1",
        "tax_id": 9606,
        "disease": "meningioma (Disease Ontology:DOID:3565); familial meningioma (Disease Ontology:DOID:4586); myeloid leukemia (Disease Ontology:DOID:8692); CEBALID syndrome (MONDO:MONDO:0032908)",
        "pathway": " (hsa:4330)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "11237011;15302935;18477386;23186163;29351928;29557506;30429286;31834374;31839203;31848261;32157095;32161166;32938616;33592498;35051231;35810559;36604386;38253038;38546519;38956580;39068559;7731705;7731706;9026990",
        "class_list": "",
        "function": "Distinctive Craniofacial and Oral Anomalies in MN1 C-terminal Truncation Syndrome. Review article, [RefSeq, PubMed]; Early ependymal tumor with MN1-BEND2 fusion: a mostly cerebral tumor of female children with a good prognosis that is distinct from classical astroblastoma. Review article, [RefSeq, PubMed]; METTL14-mediated epitranscriptome modification of MN1 mRNA promote tumorigenicity and all-trans-retinoic acid resistance in osteosarcoma., [RefSeq, PubMed]; Meningioma 1 (MN1) contains two sets of CAG repeats. It is disrupted by a balanced translocation (4;22) in a meningioma, and its inactivation may contribute to meningioma 32 pathogenesis. [provided by RefSeq, Jul 2008]., [RefSeq]; Refinement of Risk-Stratification of Cytogenetically Normal Acute Myeloid Leukemia Adult Patients by MN1 Expression. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional activator which specifically regulates expression of TBX22 in the posterior region of the developing palate. Required during later stages of palate development for growth and medial fusion of the palatal shelves. Promotes maturation and normal function of calvarial osteoblasts, including expression of the osteoclastogenic cytokine TNFSF11/RANKL. Necessary for normal development of the membranous bones of the skull (By similarity). May play a role in tumor suppression (Probable)., [UniProtKB, PubMed, UniProtKB]; Variants in HCFC1 and MN1 genes causing intellectual disability in two Pakistani families. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A9Z1V9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription;GO:0033689 negative regulation of osteoblast proliferation;GO:1902806 regulation of cell cycle G1/S phase transition;GO:0070564 positive regulation of vitamin D receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q10571-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92887-1",
        "uniprot_id": [
            {
                "id": "MRP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92887",
                "type": "external"
            }
        ],
        "mass": 174207.0,
        "length": 1545,
        "protein_name": "ATP-binding cassette sub-family C member 2",
        "gene_name": "ABCC2",
        "organism": "Human",
        "refseq_name": "ATP-binding cassette sub-family C member 2",
        "refseq_ac": [
            {
                "id": "NP_000383",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000383",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ABCC2; CMOAT1; CMOAT; CMRP; MRP2",
        "gene_names_refseq": "ABC30; ABCC2; CMOAT; DJS; MRP2; cMRP",
        "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 2; 7.6.2.-; 7.6.2.2; 7.6.2.3; Canalicular multidrug resistance protein; Canalicular multispecific organic anion transporter 1; Multidrug resistance-associated protein 2",
        "protein_names_refseq": "ATP-binding cassette sub-family C member 2; ATP-binding cassette, sub-family C (CFTR/MRP), member 2; canalicular multidrug resistance protein; canalicular multispecific organic anion transporter 1; multidrug resistance-associated protein 2",
        "tax_id": 9606,
        "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); primary biliary cholangitis (Disease Ontology:DOID:12236); Dubin-Johnson syndrome (Disease Ontology:DOID:12308); cholestasis (Disease Ontology:DOID:13580); pancreatic cancer (Disease Ontology:DOID:1793); status epilepticus (Disease Ontology:DOID:1824); epilepsy (Disease Ontology:DOID:1826); drug-induced hepatitis (Disease Ontology:DOID:2044); bilirubin metabolic disorder (Disease Ontology:DOID:2741); lung non-small cell carcinoma (Disease Ontology:DOID:3908); cholangiocarcinoma (Disease Ontology:DOID:4947); end stage renal disease (Disease Ontology:DOID:783); chronic myeloid leukemia (Disease Ontology:DOID:8552); type 2 diabetes mellitus (Disease Ontology:DOID:9352); steatotic liver disease (Disease Ontology:DOID:9452); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:1244);  (R-HSA-189483);  (R-HSA-382556);  (R-HSA-5679001);  (R-HSA-9749641);  (R-HSA-9753281);  (R-HSA-9754706)",
        "pathway_count": 7,
        "publication_count": 195,
        "publication_id_list": "10.1101/2023.09.13.557529;10053008;10220572;10421658;10434065;10464142;10484077;10601278;10620517;10644574;10665657;10741631;10748049;11023036;11038166;11093739;11134001;11237011;11266082;11397817;11477083;11500505;11504826;11562789;1157293;11581266;11714888;11812794;11950779;12379217;12379510;12403779;12441801;12473676;12604685;12615054;12616642;1352877;1356264;1359686;13741103;1377674;14661924;15001581;15175422;15245331;15472518;15497697;15801541;15863492;15899824;16258079;16332456;16696573;16816140;16837570;16858120;16901789;16943252;17482904;17523162;17627974;1783992;17855752;17894550;17924658;17977821;18232020;18282684;18357469;18434309;18452278;18669648;18691976;18720283;19002207;19415658;19447222;19463;19570978;19664994;1968359;19794410;19836360;19842618;19862647;19890061;1998343;20068231;20166139;20190787;20583968;20621639;21044052;21278621;21666065;21712391;21852972;22178883;22232210;22290738;22349737;22406294;22674043;22823425;23063411;23186163;23531488;23562342;23682772;24019521;24275569;24685677;24714562;2475911;24799396;25133187;25336012;25576301;2570070;2573352;25840124;26049587;26067475;26208431;26412035;26992070;27397612;27862975;28132103;28408210;28677105;28904123;2898143;29175180;29557506;30833945;30959153;31092671;31154438;31704245;31848261;32157095;32161166;32387766;32472168;32981041;3342084;3395122;33981976;34045219;34171305;3457471;3472246;35051231;35494241;35580925;36215666;3705620;38316776;39095325;39096023;39477313;39993711;41018975;4980931;5013373;5773090;5862532;6777177;6838677;6950087;70646;7206363;7372607;7469630;7523390;7529176;7553863;7553864;7802672;7865904;8662992;8797578;8813074;9024171;9080;9144407;931988;9414488;9425227;9652413;975718;9816258;9831708",
        "class_list": "",
        "function": "ABCC2 induces metabolic vulnerability and cellular ferroptosis via enhanced glutathione efflux in gastric cancer., [RefSeq, PubMed]; ATP-dependent transporter of the ATP-binding cassette (ABC) family that hydrolyzes ATP to enable active transport of endogenous and xenobiotic substrates conjugated with glucuronate, glutathione or sulfate. Operates at apical membranes of polarized cells such as hepatocytes, renal and intestinal epithelial cells, where it mediates hepatobiliary and renal excretion of conjugated substrates preventing them from being recycled back into the bloodstream (PubMed:10220572, PubMed:10421658, PubMed:11500505, PubMed:16332456, PubMed:29175180, PubMed:30959153, PubMed:31704245). Involved in canalicular bile production. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin, enabling bilirubin detoxification (PubMed:10421658). Mediates the efflux of steroid glucuronates and may regulate their hepatobiliary and renal metabolic clearance. Displays low affinity but high transport velocity toward androgen conjugates such as testosterone and dihydrotestosterone glucuronates as well as toward estrogen conjugates including estradiol, estrone and estriol glucuronates (PubMed:29175180, PubMed:30959153, PubMed:31704245). May control the hepatobiliary and renal efflux of inflammatory leukotriene C4 (LTC4) and related cysteinyl leukotrienes (PubMed:11500505). Transports sulfated bile salt such as taurolithocholate sulfate (PubMed:16332456). It is functionally inactive toward androgen sulfates (PubMed:39993711). Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors (PubMed:10220572, PubMed:11500505, PubMed:12441801). Can confer resistance to several anticancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine, by decreasing accumulation of these drugs in cells (PubMed:10220572, PubMed:11500505)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Association Between ABCC2 -24C>T and Nab-Paclitaxel-induced Peripheral Neuropathy in Japanese Patients With Pancreatic Cancer., [RefSeq, PubMed]; In silico and biological analyses of missense variants of the human biliary efflux transporter ABCC2: effects of novel rare missense variants., [RefSeq, PubMed]; The 5'-untranslated region of MRP2 markedly influences MRP2 mRNA translation regulation., [RefSeq, PubMed]; The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]., [RefSeq]; Transport mechanism of human bilirubin transporter ABCC2 tuned by the inter-module regulatory domain. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 17,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 16,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RMT8;Q14022;Q5T2B1;Q92500;Q92798;Q99663;Q9UMS2",
        "ec_number_list": [
            {
                "id": "7.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2",
                "type": "external"
            },
            {
                "id": "7.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-",
                "type": "external"
            },
            {
                "id": "7.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3",
                "type": "external"
            },
            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0022857 transmembrane transporter activity;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016324 apical plasma membrane;GO:0046581 intercellular canaliculus;GO:0031982 vesicle",
        "go_biological_process": "GO:0010629 negative regulation of gene expression;GO:0055085 transmembrane transport;GO:0015721 bile acid and bile salt transport;GO:0006805 xenobiotic metabolic process;GO:0006855 xenobiotic transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 20.0,
        "record_id": "Q92887-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BRP8-1",
        "uniprot_id": [
            {
                "id": "PYM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BRP8",
                "type": "external"
            }
        ],
        "mass": 22656.0,
        "length": 204,
        "protein_name": "Partner of Y14 and mago",
        "gene_name": "PYM1",
        "organism": "Human",
        "refseq_name": "partner of Y14 and mago isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001137325",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137325",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PYM1; PYM; WIBG",
        "gene_names_refseq": "PYM1; PYM; WIBG",
        "protein_names_uniprotkb": "Partner of Y14 and mago; PYM homolog 1 exon junction complex-associated factor; Protein wibg homolog",
        "protein_names_refseq": "PYM homolog 1, exon junction complex associated factor; partner of Y14 and mago isoform 2; partner of Y14 and mago; protein wibg homolog; within bgcn homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84305)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "11237011;12438415;14968132;17287340;18026120;18669648;19410547;20068231;23186163;24714562;26154972;26728094;28832583;29242379;29508533;29786170;30833945;31154438;31848261;31998317;32157095;32350084;32502341;32938616;32983136;33717175;34171305;34185709;35051231",
        "class_list": "",
        "function": "Key regulator of the exon junction complex (EJC), a multiprotein complex that associates immediately upstream of the exon-exon junction on mRNAs and serves as a positional landmark for the intron exon structure of genes and directs post-transcriptional processes in the cytoplasm such as mRNA export, nonsense-mediated mRNA decay (NMD) or translation. Acts as an EJC disassembly factor, allowing translation-dependent EJC removal and recycling by disrupting mature EJC from spliced mRNAs. Its association with the 40S ribosomal subunit probably prevents a translation-independent disassembly of the EJC from spliced mRNAs, by restricting its activity to mRNAs that have been translated. Interferes with NMD and enhances translation of spliced mRNAs, probably by antagonizing EJC functions. May bind RNA; the relevance of RNA-binding remains unclear in vivo, RNA-binding was detected by PubMed:14968132, while PubMed:19410547 did not detect RNA-binding activity independently of the EJC., [UniProtKB, PubMed, PubMed]; Suggest that PYM functions as a bridge between EJC-bearing spliced mRNAs and the translation machinery to enhance translation of the mRNAs, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B6ZDM5;Q8IXJ8;Q8N8E7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0043022 ribosome binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0035145 exon-exon junction complex",
        "go_biological_process": "GO:0000184 nuclear-transcribed mRNA catabolic process, nonsense-mediated decay;GO:0045727 positive regulation of translation;GO:1903259 exon-exon junction complex disassembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q9BRP8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14165-1",
        "uniprot_id": [
            {
                "id": "MLEC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14165",
                "type": "external"
            }
        ],
        "mass": 32234.0,
        "length": 292,
        "protein_name": "Malectin",
        "gene_name": "MLEC",
        "organism": "Human",
        "refseq_name": "malectin isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_055545",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055545",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MLEC; KIAA0152",
        "gene_names_refseq": "KIAA0152; MLEC",
        "protein_names_uniprotkb": "Malectin",
        "protein_names_refseq": "malectin isoform 1 precursor; oligosaccharyltransferase complex subunit (non-catalytic)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9761);  (R-HSA-532668);  (R-HSA-6798695)",
        "pathway_count": 3,
        "publication_count": 81,
        "publication_id_list": "10788335;10929008;11237011;12114544;12145188;15215856;15358861;15362974;15489334;16055502;16168377;17074750;18303019;18524852;20068231;20347265;21269460;21813736;22988243;23650620;24275569;24715725;25451265;25502872;25576301;25944712;26154972;26611529;27846572;28218747;28649982;28832583;28855257;28904123;28972276;29242379;29317506;29393594;29437277;29557506;30021884;30315122;30410026;30484775;30779550;30833945;31154438;31217245;31831667;31844290;31848261;32157095;32350084;32387766;32502341;32938616;33465208;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34171305;34357683;35251023;35580925;36010968;36241641;36284347;38665916;38847394;40273987;40307207;40596516;40914422;41134631;8590280;8692836",
        "class_list": "",
        "function": "Carbohydrate-binding protein with a strong ligand preference for Glc2-N-glycan. May play a role in the early steps of protein N-glycosylation (By similarity)., [UniProtKB]; Malectin is a novel carbohydrate-binding protein of the endoplasmic reticulum and a candidate player in the early steps of protein N-glycosylation, [RefSeq, PubMed]; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]; The results of in vitro studies suggest that C alleles of rs10431386 and rs7964786 on MLEC promotes cerebral palsy (CP) by inhibiting M1 to M2 macrophage polarization. Generally, this work suggested the contribution of MLEC gene polymorphisms to the pathogenesis of CP, [RefSeq, PubMed]; These observations suggest a possible role of malectin in regulating newly synthesized glycoproteins via G2M9 recognition., [RefSeq, PubMed]; These results clearly demonstrate that the association of malectin with ribophorin I is required to capture misfolded alpha1-antitrypsin and direct them to the degradation pathway., [RefSeq, PubMed]; This gene encodes the carbohydrate-binding protein malectin which is a Type I membrane-anchored endoplasmic reticulum protein. This protein has an affinity for Glc2Man9GlcNAc2 (G2M9) N-glycans and is involved in regulating glycosylation in the endoplasmic reticulum. This protein has also been shown to interact with ribophorin I and may be involved in the directing the degradation of misfolded proteins. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jan 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0051087 protein-folding chaperone binding;GO:0030246 carbohydrate binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0035579 specific granule membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "Q14165-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96JS3-1",
        "uniprot_id": [
            {
                "id": "PGBD1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96JS3",
                "type": "external"
            }
        ],
        "mass": 92515.0,
        "length": 809,
        "protein_name": "PiggyBac transposable element-derived protein 1",
        "gene_name": "PGBD1",
        "organism": "Human",
        "refseq_name": "piggyBac transposable element-derived protein 1",
        "refseq_ac": [
            {
                "id": "NP_001171672",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171672",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PGBD1; hucep-4",
        "gene_names_refseq": "HUCEP-4; PGBD1; SCAND4; dJ874C20.4",
        "protein_names_uniprotkb": "PiggyBac transposable element-derived protein 1; Cerebral protein 4",
        "protein_names_refseq": "cerebral protein 4; piggyBac transposable element-derived protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84547)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "12955498;18669648;18830724;20068231;20534741;20673877;20873219;25576301;25892735;28218747;28904123;29437277;29557506;29632046;30379171;31844290;32157095;33968037;34171305;35051231;35609796;36010968;36205081",
        "class_list": "",
        "function": "A Novel Gene Controls a New Structure: PiggyBac Transposable Element-Derived 1, Unique to Mammals, Controls Mammal-Specific Neuronal Paraspeckles., [RefSeq, PubMed]; Meta-analysis of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; The piggyBac family of proteins, found in diverse animals, are transposases related to the transposase of the canonical piggyBac transposon from the moth, Trichoplusia ni. This family also includes genes in several genomes, including human, that appear to have been derived from the piggyBac transposons. This gene belongs to the subfamily of piggyBac transposable element derived (PGBD) genes. The PGBD proteins appear to be novel, with no obvious relationship to other transposases, or other known protein families. This gene product is specifically expressed in the brain, however, its exact function is not known. Alternative splicing results in multiple transcript variants encoding the same protein.[provided by RefSeq, May 2010]., [RefSeq]; Transposase-derived from PiggyBac DNA transposons. Although it has been fully domesticated and lacks transposase activity, PGBD1 has acquired DNA-binding capability (PubMed:12955498, PubMed:35609796, PubMed:36205081). It preferentially binds in and around genes involved in neuronal development, leading to their transcriptional pausing. Notably, PGBD1 suppresses paraspeckle assembly in neuronal cells (PubMed:36205081)., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
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        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0043565 sequence-specific DNA binding",
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        "protein_names_uniprotkb": "1-acyl-sn-glycerol-3-phosphate acyltransferase alpha; 1-AGP acyltransferase 1; 1-AGPAT 1; 1-acylglycerol-3-phosphate O-acyltransferase 1; 2.3.1.51; LPAAT-alpha; Lysophosphatidic acid acyltransferase alpha; Protein G15",
        "protein_names_refseq": "1-AGP acyltransferase 1; 1-AGPAT 1; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha isoform 1 precursor; 1-acyl-sn-glycerol-3-phosphate acyltransferase alpha; 1-acylglycerol-3-phosphate O-acyltransferase 1 (acetoacetly Coenzyme A thiolase); 1-acylglycerol-3-phosphate O-acyltransferase 1 (lysophosphatidic acid acyltransferase, alpha); epididymis secretory sperm binding protein; lysophosphatidic acid acyltransferase alpha; lysophospholipid acyltransferase l; lysophospholipid acyltransferase",
        "tax_id": 9606,
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        "pathway": " (hsa:10554);  (R-HSA-1483166);  (R-HSA-163765)",
        "pathway_count": 3,
        "publication_count": 91,
        "publication_id_list": "10.1101/2023.09.13.557529;10455175;10506173;10553003;10681567;11031251;11112443;11788596;11830583;12063250;12161451;12359733;12522102;12963729;14573790;14656967;14742444;15367102;15664996;16460752;16495223;16620771;16644726;16704971;16864775;16885160;17028579;17148476;17170135;17707131;18238778;18718904;19336658;19666841;20068231;20705608;21173190;21873652;22544926;22777291;22922100;23176821;23176823;23481700;23807634;24715725;24966474;26711011;26992070;28228285;28832583;28834231;29242379;2925608;29393594;29493099;29508533;29557506;29786170;30315122;30779550;31154438;31611695;31844290;32157095;32387766;32502341;32938616;33141586;33392160;33592498;33968037;34405274;34509645;3458202;35051231;35363634;36010968;36241641;7060561;7821823;8163052;8186247;8300559;8530346;8687421;9188469;9212163;9291118;9461603;9582313",
        "class_list": "",
        "function": "AGPAT1 as a Novel Colonic Biomarker for Discriminating Between Ulcerative Colitis With and Without Primary Sclerosing Cholangitis. Publication Status: Online-Only, [RefSeq, PubMed]; Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone., [UniProtKB, PubMed, PubMed]; This gene encodes an enzyme that converts lysophosphatidic acid (LPA) into phosphatidic acid (PA). LPA and PA are two phospholipids involved in signal transduction and in lipid biosynthesis in cells. This enzyme localizes to the endoplasmic reticulum. This gene is located in the class III region of the human major histocompatibility complex. Alternative splicing results in two transcript variants encoding the same protein. [provided by RefSeq, Jul 2008]., [RefSeq]",
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        "tax_id": 9606,
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        "publication_id_list": "11141079;11237011;11389151;11447212;11675392;12665801;16401880;1648736;17114793;17411337;18532927;18687502;19603039;22694141;23650620;24023390;25341920;25892735;26154972;26969162;26992070;28218747;28832583;28904123;29242379;29312551;29393594;29437277;29493099;29557506;29632711;29769354;30131385;30158579;30165196;31530632;32357974;32926650;33717175;35705054;36581221;38536817;40307207;7957092;7991565;8164745;8349690;8375503;8513495;8631982;8662963;8692836;8836150",
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        "function": "Findings indicate that patients with low vesicle associated membrane protein 8 (VAMP8)/low rab GTP-binding protein RAB37 (RAB37) expression profile showed significantly high risk of death even after adjusting for tumor metastasis parameter., [RefSeq, PubMed]; Methionine represses the autophagy of gastric cancer stem cells via promoting the methylation and phosphorylation of RAB37., [RefSeq, PubMed]; Promoter/exon1 methylation is the predominant mechanism in down-regulation of the hRAB37, and can serve as a potential prediction biomarker of NSCLC progression., [RefSeq, PubMed]; Rab proteins are low molecular mass GTPases that are critical regulators of vesicle trafficking. For additional background information on Rab proteins, see MIM 179508.[supplied by OMIM, Apr 2006]., [RefSeq]; Rab37-mediated SFRP1 secretion suppresses cancer stemness. Publication Status: Online-Only, [RefSeq, PubMed]; The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different sets of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion (PubMed:38536817). Acts as an organizer for autophagosome biogenesis in a GTP-dependent manner (PubMed:38536817). Involved in retinal homeostasis by autophagy regulation (PubMed:38536817)., [UniProtKB, PubMed]; This study shows that RAB37 hypermethylation is involved in NPC metastasis and chemoresistance, and that our prognostic model can identify patients who are at a high risk of distant metastasis and might benefit from for docetaxel IC. Erratum:[Clin Cancer Res. 2022 Jan 15;28(2):430. doi: 10.1158/1078-0432.CCR-21-4242. PMID: 35045963], [RefSeq, PubMed]",
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                "id": "2.3.1.78",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.78",
                "type": "external"
            },
            {
                "id": "7.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67",
                "type": "external"
            },
            {
                "id": "2.3.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.42",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.42",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003924 GTPase activity;GO:0005525 GTP binding;GO:0046872 metal ion binding;GO:0003925 G protein activity",
        "go_cellular_component": "GO:0005768 endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0035579 specific granule membrane;GO:0035577 azurophil granule membrane",
        "go_biological_process": "GO:0015031 protein transport;GO:0010508 positive regulation of autophagy;GO:0017157 regulation of exocytosis;GO:0042478 regulation of eye photoreceptor cell development",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q96AX2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P82932-1",
        "uniprot_id": [
            {
                "id": "RT06_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P82932",
                "type": "external"
            }
        ],
        "mass": 14227.0,
        "length": 125,
        "protein_name": "Small ribosomal subunit protein bS6m",
        "gene_name": "MRPS6",
        "organism": "Human",
        "refseq_name": "small ribosomal subunit protein bS6m",
        "refseq_ac": [
            {
                "id": "NP_115865",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115865",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MRPS6; C21orf101; RPMS6",
        "gene_names_refseq": "C21orf101; MRP-S6; MRPS6; RPMS6; S6mt; bS6m",
        "protein_names_uniprotkb": "Small ribosomal subunit protein bS6m; 28S ribosomal protein S6, mitochondrial; MRP-S6; S6mt",
        "protein_names_refseq": "28S ribosomal protein S6, mitochondrial; mitochondrial small ribosomal subunit protein bS6m; small ribosomal subunit protein bS6m",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64968);  (R-HSA-5368286);  (R-HSA-5389840);  (R-HSA-5419276);  (R-HSA-9937383)",
        "pathway_count": 5,
        "publication_count": 47,
        "publication_id_list": "11237011;11279123;11402041;11543634;12036297;15358359;17803939;18429816;18782833;19524667;19716793;20186120;21907147;22172991;2250005;24714562;25233460;25576301;25838379;26728094;26992070;27029019;28228285;28510447;28832583;28892042;29242379;30429286;31217245;31530632;31844290;32157095;32161166;32502341;32983136;33243891;33592498;33878294;33936100;33964376;33968037;34932366;35580925;36302763;36596788;37141370;37758822",
        "class_list": "",
        "function": "MRPS6 modulates glucose-stimulated insulin secretion in mouse islet cells through mitochondrial unfolded protein response. Publication Status: Online-Only, [RefSeq, PubMed]; Mammalian mitochondrial ribosomal proteins are encoded by nuclear genes and help in protein synthesis within the mitochondrion. Mitochondrial ribosomes (mitoribosomes) consist of a small 28S subunit and a large 39S subunit. They have an estimated 75% protein to rRNA composition compared to prokaryotic ribosomes, where this ratio is reversed. Another difference between mammalian mitoribosomes and prokaryotic ribosomes is that the latter contain a 5S rRNA. Among different species, the proteins comprising the mitoribosome differ greatly in sequence, and sometimes in biochemical properties, which prevents easy recognition by sequence homology. This gene encodes a 28S subunit protein that belongs to the ribosomal protein S6P family. Pseudogenes corresponding to this gene are found on chromosomes 1p and 12q. [provided by RefSeq, Jul 2008]., [RefSeq]; Mitochondrial ribosomal small subunit proteins (MRPS) MRPS6 and MRPS23 show dysregulation in breast cancer affecting tumorigenic cellular processes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R573;Q96Q64;Q9BSK8;Q9BW89",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003735 structural constituent of ribosome;GO:0070181 small ribosomal subunit rRNA binding;GO:0019843 rRNA binding",
        "go_cellular_component": "GO:0005763 mitochondrial small ribosomal subunit;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0015935 small ribosomal subunit;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006412 translation;GO:0032543 mitochondrial translation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "P82932-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O94941-1",
        "uniprot_id": [
            {
                "id": "RNF37_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O94941",
                "type": "external"
            }
        ],
        "mass": 58966.0,
        "length": 541,
        "protein_name": "RING finger protein 37",
        "gene_name": "UBOX5",
        "organism": "Human",
        "refseq_name": "RING finger protein 37 isoform a",
        "refseq_ac": [
            {
                "id": "NP_055763",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055763",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UBOX5; KIAA0860; RNF37; UBCE7IP5; UIP5",
        "gene_names_refseq": "RNF37; UBCE7IP5; UBOX5; UIP5; hUIP5",
        "protein_names_uniprotkb": "RING finger protein 37; 2.3.2.27; RING-type E3 ubiquitin transferase RNF37; U-box domain-containing protein 5; UbcM4-interacting protein 5; Ubiquitin-conjugating enzyme 7-interacting protein 5; hUIP5",
        "protein_names_refseq": "RING finger protein 37 isoform a; RING-type E3 ubiquitin transferase RNF37; U-box domain-containing protein 5; ring finger protein 37; ubcM4-interacting protein 5; ubiquitin conjugating enzyme 7 interacting protein 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22888);  (R-HSA-983168)",
        "pathway_count": 2,
        "publication_count": 51,
        "publication_id_list": "10431818;11062501;11237011;11274149;11350924;11435423;12646216;14734113;15224091;15224092;15571818;16595681;16849449;16954532;18662542;19028597;19352404;19452197;19489725;19851334;19874575;19940261;2261476;24129315;24397554;25576301;26992070;27920218;28228285;28649982;28832583;28904123;29493099;29557506;29786170;30315122;31154438;31844290;31848261;32161166;32357974;32897882;33298915;33633747;33691108;33912179;35051231;36010968;37217939;9380723;9668046",
        "class_list": "",
        "function": "May have a ubiquitin-protein ligase activity acting as an E3 ubiquitin-protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on substrates., [UniProtKB, UniProtKB]; This gene encodes a U-box domain containing protein. The encoded protein interacts with E2 enzymes and may play a role in the ubiquitination pathway. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jun 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IAR5;Q86X87;Q9H4J2",
        "ec_number_list": [
            {
                "id": "2.3.2.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.24",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "2.3.2.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.26",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.3.2.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.31",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "6.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.2.1.-",
                "type": "external"
            },
            {
                "id": "2.3.2.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.34",
                "type": "external"
            },
            {
                "id": "2.3.2.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.32",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.3.2.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.25",
                "type": "external"
            },
            {
                "id": "2.3.2.36",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.36",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding;GO:0034450 ubiquitin-ubiquitin ligase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0016604 nuclear body",
        "go_biological_process": "GO:0000209 protein polyubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "O94941-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UGB7-1",
        "uniprot_id": [
            {
                "id": "MIOX_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UGB7",
                "type": "external"
            }
        ],
        "mass": 33010.0,
        "length": 285,
        "protein_name": "Inositol oxygenase",
        "gene_name": "MIOX",
        "organism": "Human",
        "refseq_name": "inositol oxygenase",
        "refseq_ac": [
            {
                "id": "NP_060054",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060054",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MIOX; ALDRL6; KSP32; RSOR",
        "gene_names_refseq": "ALDRL6; MIOX",
        "protein_names_uniprotkb": "Inositol oxygenase; 1.13.99.1; Aldehyde reductase-like 6; Kidney-specific protein 32; MI oxygenase; Myo-inositol oxygenase; Renal-specific oxidoreductase",
        "protein_names_refseq": "MI oxygenase; aldehyde reductase (aldose reductase) like 6; aldehyde reductase-like 6; inositol oxygenase; kidney-specific protein 32; renal-specific oxidoreductase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55586);  (R-HSA-1855183)",
        "pathway_count": 2,
        "publication_count": 27,
        "publication_id_list": "10593988;10944187;11237011;11716759;12890864;1377913;15024000;15474001;15504367;17068342;1718960;18364358;18477386;29557506;30539651;32169892;34171305;35338333;37249295;37977044;7608176;7721860;7761412;8006039;8390685;9295334;9430698",
        "class_list": "",
        "function": "Long noncoding RNA NEAT1 promotes ferroptosis by modulating the miR-362-3p/MIOX axis as a ceRNA., [RefSeq, PubMed]; MIOX inhibits autophagy to regulate the ROS -driven inhibition of STAT3/c-Myc-mediated epithelial-mesenchymal transition in clear cell renal cell carcinoma. Erratum:[Redox Biol. 2024 Feb;69:102997. doi: 10.1016/j.redox.2023.102997. PMID: 38129197], [RefSeq, PubMed]; MIOX-induced oxidant stress and tunicamycin-induced endoplasmic reticulum stress are interlinked, and both of the events may feed into each other to amplify the tubulointerstitial injury., [RefSeq, PubMed]; Myo-inositol Oxygenase (MIOX) Overexpression Drives the Progression of Renal Tubulointerstitial Injury in Diabetes., [RefSeq, PubMed]; Myo-inositol oxygenase (MIOX), [RefSeq, PubMed]; Myo-inositol oxygenase (MIOX) accelerated inflammation in the model of infection-induced cardiac dysfunction by NLRP3 inflammasome., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q05DJ6;Q5S8C9;Q9BZZ1;Q9UHB8",
        "ec_number_list": [
            {
                "id": "1.13.99.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.13.99.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008106 alcohol dehydrogenase (NADP+) activity;GO:0016651 oxidoreductase activity, acting on NAD(P)H;GO:0008199 ferric iron binding;GO:0050113 inositol oxygenase activity;GO:0005506 iron ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016234 inclusion body",
        "go_biological_process": "GO:0019310 inositol catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q9UGB7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H2D1-1",
        "uniprot_id": [
            {
                "id": "S2532_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H2D1",
                "type": "external"
            }
        ],
        "mass": 35407.0,
        "length": 315,
        "protein_name": "Solute carrier family 25 member 32",
        "gene_name": "SLC25A32",
        "organism": "Human",
        "refseq_name": "solute carrier family 25 member 32",
        "refseq_ac": [
            {
                "id": "NP_110407",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_110407",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC25A32; MFTC; MFT",
        "gene_names_refseq": "GLYB; MFTC; MFT; RREI; SLC25A32",
        "protein_names_uniprotkb": "Solute carrier family 25 member 32; Mitochondrial FAD transporter",
        "protein_names_refseq": "Glycine auxotroph B, complementation of hamster; glycine B complementing; mitochondrial FAD transporter; mitochondrial folate transporter/carrier; solute carrier family 25 (mitochondrial folate carrier), member 32; solute carrier family 25 member 32",
        "tax_id": 9606,
        "disease": "multiple acyl-CoA dehydrogenase deficiency (Disease Ontology:DOID:0060358); exercise intolerance, riboflavin-responsive (MONDO:MONDO:0014795); neural tube defects, susceptibility to (MONDO:MONDO:0020705)",
        "pathway": " (hsa:81034);  (R-HSA-196757)",
        "pathway_count": 2,
        "publication_count": 119,
        "publication_id_list": "10091649;10347183;10978331;11237011;12937168;15140890;16165386;16171773;17129779;17308042;17962486;19362304;19424049;19531498;19948730;20498374;20877624;21163947;21238436;21876188;2248959;23409799;23934049;24366607;24714562;24715725;24733394;25418920;25576301;25645385;25802875;25892735;2605182;26154972;26375851;26728094;26811146;26929215;26933868;26992070;27600516;27846572;27920218;28218747;28228285;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29632711;29666258;29769354;29786170;30315122;30524438;3053686;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32357974;32387766;32423175;32488085;32502341;32658475;32938616;32983136;33053560;33141586;33163492;33298915;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34509645;34764427;34932366;35051231;35561310;35580925;35727412;36010968;36241641;36284347;37365560;37938771;3801490;3871768;4066659;6323448;7726158;7852378;8218174;8522195;8662720;9753690",
        "class_list": "",
        "function": "Facilitates flavin adenine dinucleotide (FAD) translocation across the mitochondrial inner membrane into the mitochondrial matrix where it acts as a redox cofactor to assist flavoenzyme activities in fundamental metabolic processes including fatty acid beta-oxidation, amino acid and choline metabolism as well as mitochondrial electron transportation. In particular, provides FAD to DLD dehydrogenase of the glycine cleavage system, part of mitochondrial one-carbon metabolic pathway involved in neural tube closure in early embryogenesis., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Hypoketotic hypoglycemia without neuromuscular complications in patients with SLC25A32 deficiency., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Patient with SLC25A32 deficiency was able to have a successful pregnancy after fertilization in vitro., [RefSeq, PubMed]; SLC25A32 promotes malignant progression of glioblastoma by activating PI3K-AKT signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; These data demonstrate that the loss of functional Slc25a32 results in cranial neural tube defects (NTDs) in mice and has also been observed in a human NTD patient., [RefSeq, PubMed]; This gene encodes a member of the P(I/L)W subfamily of mitochondrial carrier family transport proteins. The encoded protein transports folate across the inner mitochondrial membrane. Alternatively spliced transcript variants have been described. [provided by RefSeq, Mar 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "biomarker_type": "",
        "glycan_count": 0,
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        "secondary_ac_list": "A0A024R9D0;Q96JZ6;Q96SU7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008517 folic acid transmembrane transporter activity;GO:0015230 FAD transmembrane transporter activity;GO:0015215 nucleotide transmembrane transporter activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0055085 transmembrane transport;GO:0046655 folic acid metabolic process;GO:1990548 mitochondrial FAD transmembrane transport;GO:0006862 nucleotide transport;GO:0015711 organic anion transport",
        "synthesized_glycan_count": 0,
        "hit_score": 12.0,
        "record_id": "Q9H2D1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15759-1",
        "uniprot_id": [
            {
                "id": "MK11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15759",
                "type": "external"
            }
        ],
        "mass": 41357.0,
        "length": 364,
        "protein_name": "Mitogen-activated protein kinase 11",
        "gene_name": "MAPK11",
        "organism": "Human",
        "refseq_name": "mitogen-activated protein kinase 11",
        "refseq_ac": [
            {
                "id": "NP_002742",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002742",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAPK11; PRKM11; SAPK2B; SAPK2",
        "gene_names_refseq": "MAPK11; P38BETA2; P38B; PRKM11; SAPK2B; SAPK2; p38-2; p38Beta",
        "protein_names_uniprotkb": "Mitogen-activated protein kinase 11; 2.7.11.24; MAP kinase 11; MAP kinase p38 beta; MAPK 11; Mitogen-activated protein kinase p38 beta; SAPK2b; Stress-activated protein kinase 2b; p38-2; p38b",
        "protein_names_refseq": "MAP kinase 11; MAP kinase p38 beta; mitogen-activated protein kinase 11; mitogen-activated protein kinase p38 beta; mitogen-activated protein kinase p38-2; stress-activated protein kinase-2b",
        "tax_id": 9606,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:5600);  (R-HSA-168638);  (R-HSA-171007);  (R-HSA-198753);  (R-HSA-2151209);  (R-HSA-2559580);  (R-HSA-4420097);  (R-HSA-450302);  (R-HSA-450341);  (R-HSA-450604);  (R-HSA-525793);  (R-HSA-5668599);  (R-HSA-6804756);  (R-HSA-69601)",
        "pathway_count": 14,
        "publication_count": 291,
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        "class_list": "",
        "function": "SARS-CoV-2 hijacks p38beta/MAPK11 to promote virus replication., [RefSeq, PubMed]; Serine/threonine kinase which acts as an essential component of the MAP kinase signal transduction pathway (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 is one of the four p38 MAPKs which play an important role in the cascades of cellular responses evoked by extracellular stimuli such as pro-inflammatory cytokines or physical stress leading to direct activation of transcription factors (PubMed:12452429, PubMed:20626350, PubMed:35857590). Accordingly, p38 MAPKs phosphorylate a broad range of proteins and it has been estimated that they may have approximately 200 to 300 substrates each (PubMed:12452429, PubMed:20626350, PubMed:35857590). MAPK11 functions are mostly redundant with those of MAPK14 (PubMed:12452429, PubMed:20626350, PubMed:35857590). Some of the targets are downstream kinases which are activated through phosphorylation and further phosphorylate additional targets (PubMed:12452429, PubMed:20626350). RPS6KA5/MSK1 and RPS6KA4/MSK2 can directly phosphorylate and activate transcription factors such as CREB1, ATF1, the NF-kappa-B isoform RELA/NFKB3, STAT1 and STAT3, but can also phosphorylate histone H3 and the nucleosomal protein HMGN1 (PubMed:9687510). RPS6KA5/MSK1 and RPS6KA4/MSK2 play important roles in the rapid induction of immediate-early genes in response to stress or mitogenic stimuli, either by inducing chromatin remodeling or by recruiting the transcription machinery. On the other hand, two other kinase targets, MAPKAPK2/MK2 and MAPKAPK3/MK3, participate in the control of gene expression mostly at the post-transcriptional level, by phosphorylating ZFP36 (tristetraprolin) and ELAVL1, and by regulating EEF2K, which is important for the elongation of mRNA during translation. MKNK1/MNK1 and MKNK2/MNK2, two other kinases activated by p38 MAPKs, regulate protein synthesis by phosphorylating the initiation factor EIF4E2 (PubMed:11154262). In the cytoplasm, the p38 MAPK pathway is an important regulator of protein turnover. For example, CFLAR is an inhibitor of TNF-induced apoptosis whose proteasome-mediated degradation is regulated by p38 MAPK phosphorylation. Ectodomain shedding of transmembrane proteins is regulated by p38 MAPKs as well. In response to inflammatory stimuli, p38 MAPKs phosphorylate the membrane-associated metalloprotease ADAM17. Such phosphorylation is required for ADAM17-mediated ectodomain shedding of TGF-alpha family ligands, which results in the activation of EGFR signaling and cell proliferation. Additional examples of p38 MAPK substrates are the FGFR1. FGFR1 can be translocated from the extracellular space into the cytosol and nucleus of target cells, and regulates processes such as rRNA synthesis and cell growth. FGFR1 translocation requires p38 MAPK activation. In the nucleus, many transcription factors are phosphorylated and activated by p38 MAPKs in response to different stimuli. Classical examples include ATF1, ATF2, ATF6, ELK1, PTPRH, DDIT3, TP53/p53 and MEF2C and MEF2A (PubMed:10330143, PubMed:15356147, PubMed:9430721). The p38 MAPKs are emerging as important modulators of gene expression by regulating chromatin modifiers and remodelers (PubMed:10330143, PubMed:15356147, PubMed:9430721). The promoters of several genes involved in the inflammatory response, such as IL6, IL8 and IL12B, display a p38 MAPK-dependent enrichment of histone H3 phosphorylation on 'Ser-10' (H3S10ph) in LPS-stimulated myeloid cells. This phosphorylation enhances the accessibility of the cryptic NF-kappa-B-binding sites marking promoters for increased NF-kappa-B recruitment. Phosphorylates NLRP1 downstream of MAP3K20/ZAK in response to UV-B irradiation and ribosome collisions, promoting activation of the NLRP1 inflammasome and pyroptosis (PubMed:35857590). Phosphorylates methyltransferase DOT1L on 'Ser-834', 'Thr-900', 'Ser-902', 'Thr-984', 'Ser-1001', 'Ser-1009' and 'Ser-1104' (PubMed:38270553)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a member of a family of protein kinases that are involved in the integration of biochemical signals for a wide variety of cellular processes, including cell proliferation, differentiation, transcriptional regulation, and development. The encoded protein can be activated by proinflammatory cytokines and environmental stresses through phosphorylation by mitogen activated protein kinase kinases (MKKs). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]., [RefSeq]",
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        "secondary_ac_list": "A8K730;B0LPG1;B7Z630;E7ETQ1;L7RT27;O00284;O15472;Q2XNF2",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
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            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0004707 MAP kinase activity;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0071493 cellular response to UV-B;GO:0006351 DNA-templated transcription;GO:0010628 positive regulation of gene expression;GO:0035556 intracellular signal transduction;GO:0051149 positive regulation of muscle cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 29.2,
        "record_id": "Q15759-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14696-1",
        "uniprot_id": [
            {
                "id": "MESD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14696",
                "type": "external"
            }
        ],
        "mass": 26077.0,
        "length": 234,
        "protein_name": "LRP chaperone MESD",
        "gene_name": "MESD",
        "organism": "Human",
        "refseq_name": "LRP chaperone MESD precursor",
        "refseq_ac": [
            {
                "id": "NP_055969",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055969",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MESD; KIAA0081; MESDC2; MESDM; PRO4369",
        "gene_names_refseq": "BOCA; MESDC2; MESD; OI20",
        "protein_names_uniprotkb": "LRP chaperone MESD; LDLR chaperone MESD; Mesoderm development LRP chaperone MESD; Mesoderm development candidate 2; Mesoderm development protein; Renal carcinoma antigen NY-REN-61",
        "protein_names_refseq": "LDLR chaperone MESD; LRP chaperone MESD precursor; mesoderm development LRP chaperone MESD; mesoderm development candidate 2; mesoderm development protein; renal carcinoma antigen NY-REN-61",
        "tax_id": 9606,
        "disease": "osteogenesis imperfecta type 20 (Disease Ontology:DOID:0111849)",
        "pathway": " (hsa:23184)",
        "pathway_count": 1,
        "publication_count": 52,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10508479;11237011;12975309;15014448;15917269;17488095;23572575;23584533;24714562;25813380;26811146;27846572;27920218;28832583;28834231;29242379;29393594;29493099;29557506;29632046;29632711;30429286;30779550;31020640;31564437;31611695;31844290;31848261;32157095;32265295;32350084;32387766;32488085;32938616;32983136;33043033;33592498;33596325;33968037;33981976;34087483;34171305;34357683;34509645;35051231;35154160;35251023;36010968;36215666;36284347",
        "class_list": "",
        "function": "As a result of (12;15)(q13;q25)translocation, the SUMO/Sentrin-specific protease 1 gene (SENP1) on chromosome 12 and the embryonic polarity-related mesoderm development gene (MESDC2) on chromosome 15 are disrupted and fused, [RefSeq, PubMed]; Chaperone specifically assisting the folding of beta-propeller/EGF modules within the family of low-density lipoprotein receptors (LDLRs). Acts as a modulator of the Wnt pathway through chaperoning the coreceptors of the canonical Wnt pathway, LRP5 and LRP6, to the plasma membrane. Essential for specification of embryonic polarity and mesoderm induction. Plays an essential role in neuromuscular junction (NMJ) formation by promoting cell-surface expression of LRP4. May regulate phagocytosis of apoptotic retinal pigment epithelium (RPE) cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Compound Heterozygous Frameshift Mutations in MESD Cause a Lethal Syndrome Suggestive of Osteogenesis Imperfecta Type XX., [RefSeq, PubMed]; Osteogenesis imperfecta-associated MESD mutations produce hypomorphic alleles whose failure to remain within the endoplasmic reticulum significantly reduces but does not completely eliminate LRP5 and LRP6 trafficking, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DW84;D3DW96;Q969U1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0044183 protein folding chaperone",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016604 nuclear body",
        "go_biological_process": "GO:1904395 positive regulation of skeletal muscle acetylcholine-gated channel clustering;GO:0072659 protein localization to plasma membrane;GO:0006909 phagocytosis;GO:0006457 protein folding;GO:0016055 Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 5.6,
        "record_id": "Q14696-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z6M3-1",
        "uniprot_id": [
            {
                "id": "MILR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z6M3",
                "type": "external"
            }
        ],
        "mass": 38735.0,
        "length": 343,
        "protein_name": "Allergin-1",
        "gene_name": "MILR1",
        "organism": "Human",
        "refseq_name": "allergin-1 isoform Allergin-1L precursor",
        "refseq_ac": [
            {
                "id": "NP_001078892",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078892",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MILR1; C17orf60; MCA32",
        "gene_names_refseq": "Allergin-1; C17orf60; MCA-32; MCA32; MILR1",
        "protein_names_uniprotkb": "Allergin-1; Allergy inhibitory receptor 1; MCA-32; Mast cell antigen 32; Mast cell immunoglobulin-like receptor 1",
        "protein_names_refseq": "allergin-1 isoform Allergin-1L precursor; allergy inhibitory receptor 1; probable mast cell antigen 32 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284021)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;20526344;24116093;24190977;24552759;25007884;29557506;31844290;32350084;32938616;32983136;33968037;35051231;35251023;35580925;36444625;37074911",
        "class_list": "",
        "function": "Allergin-1S1, a splicing isoform of Allergin-1, is predominantly expressed on human primary MC in both bronchoalveolar lavage fluid and nasal scratching specimens. Moreover, Allergin-1S1 inhibits IgE-mediated activation from human primary MC in BAL fluid. Publication Status: Online-Only, [RefSeq, PubMed]; Data indicate that the rs6504230 polymorphism affects MILR1 (mast cell immunoglobulin-like receptor 1; synonyms, Allergin-1) expression levels, leading to a susceptibility to producing specific IgE antibodies against common allergens., [RefSeq, PubMed]; Differential isoform expression of Allergin-1 during acute and chronic inflammation., [RefSeq, PubMed]; Immunoglobulin-like receptor which plays an inhibitory role in degranulation of mast cells. Negatively regulates IgE-mediated mast cell activation and suppresses the type I immediate hypersensitivity reaction (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; It is a immunoglobulin-like receptor which regulates the activation of mast cell.(review) Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 9577,
        "biomarker_type": "",
        "glycan_count": 10,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L458;B4DUS1;B7ZM50;B9EGN0;D6RUW6;D6RUW8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0006955 immune response;GO:0007166 cell surface receptor signaling pathway;GO:0043303 mast cell degranulation;GO:0033004 negative regulation of mast cell activation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q7Z6M3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O96007-1",
        "uniprot_id": [
            {
                "id": "MOC2B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O96007",
                "type": "external"
            }
        ],
        "mass": 20944.0,
        "length": 188,
        "protein_name": "Molybdopterin synthase catalytic subunit",
        "gene_name": "MOCS2",
        "organism": "Human",
        "refseq_name": "molybdopterin synthase catalytic subunit large subunit MOCS2B",
        "refseq_ac": [
            {
                "id": "NP_004522",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004522",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MOCS2; MCBPE; MOCO1",
        "gene_names_refseq": "MCBPE; MOCO1; MOCODB1; MOCODB; MOCS2; MPTS",
        "protein_names_uniprotkb": "Molybdopterin synthase catalytic subunit; 2.8.1.12; MOCO1-B; MOCS2B; MPT synthase large subunit; Molybdenum cofactor synthesis protein 2 large subunit; Molybdenum cofactor synthesis protein 2B; Molybdopterin-synthase large subunit",
        "protein_names_refseq": "molybdenum cofactor biosynthesis protein E; molybdopterin synthase catalytic subunit large subunit MOCS2B",
        "tax_id": 9606,
        "disease": "molybdenum cofactor deficiency type B (Disease Ontology:DOID:0111163)",
        "pathway": " (hsa:4338);  (R-HSA-947581)",
        "pathway_count": 2,
        "publication_count": 72,
        "publication_id_list": "10053003;10053004;11237011;11302742;11746050;12571226;12732628;12754701;15073332;15910006;16021469;16737835;16964243;17158010;17459099;17704913;18491921;18650437;18669648;18691976;19690332;20068231;20865336;21031595;21907887;22453920;22759696;23147983;23186163;23301498;23481700;24275569;25576301;25709896;26375851;26705305;27289259;27893789;28218747;28832583;28834231;29393594;29437277;29508533;29557506;29696052;29789417;30833945;30900395;31092671;31201073;31217245;31844290;31848698;32157095;33066491;33502714;33592498;33968037;34012852;34087483;34171305;34674206;35494241;35692435;35744859;36980992;37371303;39005576;39695700;9889283;9990024",
        "class_list": "",
        "function": "Acts as a sulfur carrier required for molybdopterin biosynthesis (PubMed:22453920). Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3 (PubMed:25709896, PubMed:12732628, PubMed:22453920). After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin (PubMed:22453920)., [UniProtKB, HAMAP, PubMed, PubMed, PubMed]; Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin., [UniProtKB, HAMAP, UniProtKB]; Beyond Moco Biosynthesis-Moonlighting Roles of MoaE and MOCS2. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group (By similarity) (PubMed:12732628, PubMed:15073332, PubMed:25709896). Together with MBIP, inhibits the activity of stress kinase EIF2AK2/PKR; this may suppress JNK activation and subsequent stress-responsive transcription, or suppress eIF2a phosphorylation to favor translation (PubMed:26705305)., [UniProtKB, PubMed, HAMAP, PubMed, PubMed, PubMed]; Eukaryotic molybdoenzymes use a unique molybdenum cofactor (MoCo) consisting of a pterin, termed molybdopterin, and the catalytically active metal molybdenum. MoCo is synthesized from precursor Z by the heterodimeric enzyme molybdopterin synthase. The large and small subunits of molybdopterin synthase are both encoded from this gene by overlapping open reading frames. The proteins were initially thought to be encoded from a bicistronic transcript. They are now thought to be encoded from monocistronic transcripts. Alternatively spliced transcripts have been found for this locus that encode the large and small subunits. [provided by RefSeq, Jul 2008]., [RefSeq]; There was undisturbed production of both transcripts, while Western blot analysis demonstrated that MOCS2B, the large subunit, is unstable in the absence of MOCS2A., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IAI3",
        "ec_number_list": [
            {
                "id": "2.8.1.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.12",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0030366 molybdopterin synthase activity;GO:0000166 nucleotide binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:1990140 molybdopterin synthase complex",
        "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0032324 molybdopterin cofactor biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 7.5,
        "record_id": "O96007-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NXC5-1",
        "uniprot_id": [
            {
                "id": "MIOS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NXC5",
                "type": "external"
            }
        ],
        "mass": 98584.0,
        "length": 875,
        "protein_name": "GATOR2 complex protein MIOS",
        "gene_name": "MIOS",
        "organism": "Human",
        "refseq_name": "GATOR2 complex protein MIOS isoform 1",
        "refseq_ac": [
            {
                "id": "NP_061878",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061878",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MIOS",
        "gene_names_refseq": "MIOS; MIO; Sea4; Yulink",
        "protein_names_uniprotkb": "GATOR2 complex protein MIOS; Missing oocyte meiosis regulator homolog",
        "protein_names_refseq": "GATOR complex protein MIOS; GATOR2 complex protein MIOS isoform 1; GATOR2 complex protein MIOS; H_DJ1159O04.1; WD repeat-containing protein mio; WUGSC:H_DJ1159O04.1; missing oocyte, meiosis regulator, homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54468);  (R-HSA-9639288)",
        "pathway_count": 2,
        "publication_count": 109,
        "publication_id_list": "11230166;11237011;15854902;15878852;16098514;16964243;17470430;18497260;18604198;18669648;18691976;19413330;19415658;19664994;19664995;19690332;20058876;20068231;20381137;21406692;22053050;22544926;22575674;22980980;23186163;23481700;23723238;24081491;24095279;25259925;25263562;25418920;25457612;25561175;25567906;25819761;25880248;25892735;26154972;26375851;26449471;26586190;26811146;26929215;26972053;26992070;27308486;27487210;27648300;27862975;27920218;28063628;28066558;28199306;28199315;28218747;28228285;28514659;28832583;28834231;28904123;29053970;29056322;29123071;29236692;29242379;29331515;29393594;29437277;29508533;29557506;29632046;29769354;29786170;30061680;30181260;30429286;30524438;30651352;31844290;32157095;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33691108;33717175;33936100;33968037;34185709;34211107;34290409;34509645;34561969;34725712;34932366;35051231;35580925;35831510;36284347;36528027;36581221;7499430",
        "class_list": "",
        "function": "As a component of the GATOR2 complex, functions as an activator of the amino acid-sensing branch of the mTORC1 signaling pathway (PubMed:23723238, PubMed:26586190, PubMed:27487210, PubMed:35831510, PubMed:36528027). The GATOR2 complex indirectly activates mTORC1 through the inhibition of the GATOR1 subcomplex (PubMed:23723238, PubMed:26586190, PubMed:27487210, PubMed:35831510, PubMed:36528027). GATOR2 probably acts as an E3 ubiquitin-protein ligase toward GATOR1 (PubMed:36528027). In the presence of abundant amino acids, the GATOR2 complex mediates ubiquitination of the NPRL2 core component of the GATOR1 complex, leading to GATOR1 inactivation (PubMed:36528027). In the absence of amino acids, GATOR2 is inhibited, activating the GATOR1 complex (PubMed:25263562, PubMed:25457612, PubMed:26586190, PubMed:27487210). Within the GATOR2 complex, MIOS is required to prevent autoubiquitination of WDR24, the catalytic subunit of the complex (PubMed:35831510). The GATOR2 complex is required for brain myelination (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RTV6;O75216;Q7L551;Q9H092",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005765 lysosomal membrane;GO:0061700 GATOR2 complex",
        "go_biological_process": "GO:1904263 positive regulation of TORC1 signaling;GO:0032289 central nervous system myelin formation;GO:0031669 cellular response to nutrient levels;GO:0034198 cellular response to amino acid starvation;GO:0031503 protein-containing complex localization",
        "synthesized_glycan_count": 0,
        "hit_score": 11.2,
        "record_id": "Q9NXC5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13724-1",
        "uniprot_id": [
            {
                "id": "MOGS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13724",
                "type": "external"
            }
        ],
        "mass": 91918.0,
        "length": 837,
        "protein_name": "Mannosyl-oligosaccharide glucosidase",
        "gene_name": "MOGS",
        "organism": "Human",
        "refseq_name": "mannosyl-oligosaccharide glucosidase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001139630",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139630",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MOGS; GCS1",
        "gene_names_refseq": "CDG2B; CWH41; DER7; GCS1; MOGS",
        "protein_names_uniprotkb": "Mannosyl-oligosaccharide glucosidase; 3.2.1.106; Processing A-glucosidase I",
        "protein_names_refseq": "epididymis secretory sperm binding protein; mannosyl-oligosaccharide glucosidase isoform 2; processing A-glucosidase I",
        "tax_id": 9606,
        "disease": "congenital disorder of glycosylation type IIb (Disease Ontology:DOID:0070254)",
        "pathway": " (hsa:7841);  (R-HSA-4793954);  (R-HSA-532668);  (R-HSA-9683686);  (R-HSA-9694548);  (R-HSA-9768727)",
        "pathway_count": 6,
        "publication_count": 96,
        "publication_id_list": "10788335;10929008;11237011;11942856;12114544;12145188;15215856;15358861;15362974;16055502;16168377;17261850;18491227;18524852;20129637;22375065;22424782;22645359;22915798;24681004;24715725;24716661;24966173;25348530;26154972;26416966;26611529;26805780;26811146;26992070;27255086;27846572;28512129;28904123;29242379;29437277;29493099;29557506;29741879;30429286;30587846;30779550;31154438;31217245;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32350084;32357974;32363391;32366695;32387766;32488085;32502341;32518941;32676595;32897882;32938616;32983136;33141586;33214551;33261925;33298915;33310888;33392160;33717175;33912179;33936100;33968037;34019948;34087483;34117209;34171305;34211107;34357683;34428449;34509645;34528721;34599882;34725712;34932366;34961524;35051231;35251023;35580925;36010968;37217939;39534244;40914422;7635146;7982500;7986008",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "A shortened immunoglobulin half-life was determined to be the mechanism underlying the hypogammaglobulinemia in congenital disorder of glycosylation type IIb (CDG-IIb)., [RefSeq, PubMed]; Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Compound heterozygous variants in MOGS gene is associated with congenital disorders of glycosylation IIb., [RefSeq, PubMed]; Congenital disorders of glycosylation type IIb with MOGS mutations cause early infantile epileptic encephalopathy, dysmorphic features, and hepatic dysfunction., [RefSeq, PubMed]; In the context of N-glycan degradation, cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor in a highly specific manner., [UniProtKB, PubMed]; Perturbation of free oligosaccharide trafficking in endoplasmic reticulum glucosidase I-deficient and castanospermine-treated cells., [RefSeq, PubMed]; This gene encodes the first enzyme in the N-linked oligosaccharide processing pathway. The enzyme cleaves the distal alpha-1,2-linked glucose residue from the Glc(3)-Man(9)-GlcNAc(2) oligosaccharide precursor. This protein is located in the lumen of the endoplasmic reticulum. Defects in this gene are a cause of type IIb congenital disorder of glycosylation (CDGIIb). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1109,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K938;F5H6D0;Q17RN9;Q8TCT5",
        "ec_number_list": [
            {
                "id": "3.2.1.106",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.106",
                "type": "external"
            },
            {
                "id": "3.2.1.207",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.207",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004573 Glc3Man9GlcNAc2 oligosaccharide glucosidase activity;GO:0015926 glucosidase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0019082 viral protein processing;GO:0006457 protein folding;GO:0006487 protein N-linked glycosylation;GO:0009311 oligosaccharide metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "Q13724-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000000.100.10100",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75121-1",
        "uniprot_id": [
            {
                "id": "MFA3L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75121",
                "type": "external"
            }
        ],
        "mass": 45380.0,
        "length": 409,
        "protein_name": "Microfibrillar-associated protein 3-like",
        "gene_name": "MFAP3L",
        "organism": "Human",
        "refseq_name": "microfibrillar-associated protein 3-like isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001009554",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009554",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MFAP3L; HSD-39; HSD39; KIAA0626",
        "gene_names_refseq": "MFAP3L; NYD-sp9",
        "protein_names_uniprotkb": "Microfibrillar-associated protein 3-like; Testis development protein NYD-SP9",
        "protein_names_refseq": "microfi brillar-associated protein 3-like; microfibrillar associated protein 3 like; microfibrillar-associated protein 3-like isoform 2; testis development protein NYD-SP9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9848)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "11237011;22299025;24735981;28218747;28832583;28834231;29242379;31844290;32157095;32350084;32488085;33592498;33968037;34357683;35051231;35154160;35580925;37217939",
        "class_list": "",
        "function": "MFAP3L activation promotes colorectal cancer cell invasion and metastasis., [RefSeq, PubMed]; May participate in the nuclear signaling of EGFR and MAPK1/ERK2. May a have a role in metastasis., [UniProtKB, PubMed]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K1X6;D3DP35;Q4W5N7;Q4W5N9;Q6TNA8;Q9BVE1;Q9BXK0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0030054 cell junction",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "O75121-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NCK7-1",
        "uniprot_id": [
            {
                "id": "MOT11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NCK7",
                "type": "external"
            }
        ],
        "mass": 45045.0,
        "length": 447,
        "protein_name": "Monocarboxylate transporter 11",
        "gene_name": "SLC16A11",
        "organism": "Human",
        "refseq_name": "monocarboxylate transporter 11 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001357478",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001357478",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC16A11; MCT11",
        "gene_names_refseq": "MCT 11; MCT11; SLC16A11",
        "protein_names_uniprotkb": "Monocarboxylate transporter 11; MCT 11; Solute carrier family 16 member 11",
        "protein_names_refseq": "monocarboxylate transporter 11 isoform 1; monocarboxylate transporter 11; monocarboxylic acid transporter 11; solute carrier family 16 (monocarboxylic acid transporters), member 11",
        "tax_id": 9606,
        "disease": "type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:162515)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;24390345;25839936;26487785;28101933;28666119;30696834;33561739;33909378;35831226;38530923",
        "class_list": "",
        "function": "Despite type 2 diabetes having been well studied by GWAS in other populations, analysis in Mexican and Latin American individuals identified SLC16A11 as a novel candidate gene for type 2 diabetes with a possible role in triacylglycerol metabolism., [RefSeq, PubMed]; Downregulation of SLC16A11 is Present in Offspring of Mothers with Gestational Diabetes., [RefSeq, PubMed]; Epistasis Between HLA-DRB1*16:02:01 and SLC16A11 T-C-G-T-T Reduces Odds for Type 2 Diabetes in Southwest American Indians., [RefSeq, PubMed]; Genetic association studies show that common variants in ABCA1 and SLC16A11 are involved in type 2 diabetes (T2D) susceptibility. Particularly, the variants rs10811661 (CDKN2A/2B) and rs9282541 (ABCA1) are associated with T2D in adult Maya population., [RefSeq, PubMed]; Genetic variants in the SLC16A11 gene are associated with increased BMI and insulin levels in nondiabetic Chilean population., [RefSeq, PubMed]; Our study identified an association between the SLC16A11 variant rs75493593 and type 2 diabetes in American Indians, where the effect on diabetes was much more pronounced in nonobese individuals. rs75493593 was also associated with RNASEK gene expression., [RefSeq, PubMed]; Proton-linked monocarboxylate transporter. It catalyzes the transport of pyruvate across the plasma membrane (PubMed:28666119). Probably involved in hepatic lipid metabolism: overexpression results in an increase of triacylglycerol(TAG) levels, small increases in intracellular diacylglycerols and decreases in lysophosphatidylcholine, cholesterol ester and sphingomyelin lipids (PubMed:24390345)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Rs13342232 might be involved in the risk of pediatric-onset type 2 diabetes in Mexican families, [RefSeq, PubMed]; The association between SLC16A11 haplotype and lipid metabolism in Japanese patients with type 2 diabetes., [RefSeq, PubMed]; The previously reported effects of SLC16A11 variants shown to be associated with diabetes in Mexicans was replicated in a large Mexican-American sample, but these effects were not significant in five non-Mexican Hispanic/Latino groups sampled from U.S. populations. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A590UJX4;I3L431",
        "ec_number_list": [],
        "go_molecular_function": "GO:0015293 symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0050833 pyruvate transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006629 lipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8NCK7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y4G8-1",
        "uniprot_id": [
            {
                "id": "RPGF2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y4G8",
                "type": "external"
            }
        ],
        "mass": 167417.0,
        "length": 1499,
        "protein_name": "Rap guanine nucleotide exchange factor 2",
        "gene_name": "RAPGEF2",
        "organism": "Human",
        "refseq_name": "rap guanine nucleotide exchange factor 2 isoform 5",
        "refseq_ac": [
            {
                "id": "NP_055062",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055062",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RAPGEF2; KIAA0313; NRAPGEP; PDZGEF1",
        "gene_names_refseq": "CNrasGEF; NRAPGEP; PDZ-GEF1; PDZGEF1; RA-GEF-1; RA-GEF; RAGEF; RAPGEF2; Rap-GEP; nRap GEP",
        "protein_names_uniprotkb": "Rap guanine nucleotide exchange factor 2; CNrasGEF; Cyclic nucleotide ras GEF; Neural RAP guanine nucleotide exchange protein; PDZ domain-containing guanine nucleotide exchange factor 1; PDZ-GEF1; RA-GEF-1; Ras/Rap1-associating GEF-1; nRap GEP",
        "protein_names_refseq": "PDZ domain containing guanine nucleotide exchange factor (GEF) 1; PDZ domain-containing guanine nucleotide exchange factor 1; RA(Ras/Rap1A-associating)-GEF; Rap guanine nucleotide exchange factor (GEF) 2; cyclic nucleotide ras GEF; neural RAP guanine nucleotide exchange protein; rap guanine nucleotide exchange factor 2 isoform 5; ras/Rap1-associating GEF-1",
        "tax_id": 9606,
        "disease": "familial adult myoclonic epilepsy 7 (Disease Ontology:DOID:0111694)",
        "pathway": " (hsa:9693);  (R-HSA-5673001)",
        "pathway_count": 2,
        "publication_count": 128,
        "publication_id_list": "10508167;10548487;10608844;10608883;10801446;10869344;10934204;11027663;11090077;11136978;11168587;11237011;11313946;11359771;11546808;11598133;11702783;12032311;12094235;12121613;12391161;14506247;14707138;15356145;1545823;15546878;16272156;16627759;16684964;17081983;1716764;17525332;17724123;17998941;18088087;18669648;18775330;18796635;1898771;19279408;19651622;19920141;20068231;20478380;21102635;21372320;21779497;21779505;21840392;21993244;22569528;22589270;22750304;23103841;23186163;23303910;23443682;23481700;23575685;23800469;24715725;24897931;24937142;25189171;25219551;25645385;25781681;26085527;26375851;26811146;26992070;27600516;27862975;28657654;28778966;28832583;28834231;28904123;29237092;29242379;29351928;29393594;29493099;29507423;29557506;29632711;29786170;30059200;30620550;31135801;31171376;31492838;31844290;32157095;32357974;32488085;32938616;32983136;33298915;33345400;33392160;33537174;33592498;33936100;33968037;34171305;34561969;34932366;35051231;35254053;35513511;35580925;36010968;37938771;39302247;39531497;6148751;7809086;7935463;7972015;8052307;8394845;8493579;8665852;8710374;8939933;9604935;9927426",
        "class_list": "",
        "function": "Disruption of MAGI2-RapGEF2-Rap1 signaling contributes to podocyte dysfunction in congenital nephrotic syndrome caused by mutations in MAGI2., [RefSeq, PubMed]; Functions as a guanine nucleotide exchange factor (GEF), which activates Rap and Ras family of small GTPases by exchanging bound GDP for free GTP in a cAMP-dependent manner. Serves as a link between cell surface receptors and Rap/Ras GTPases in intracellular signaling cascades. Also acts as an effector for Rap1 by direct association with Rap1-GTP thereby leading to the amplification of Rap1-mediated signaling. Shows weak activity on HRAS. It is controversial whether RAPGEF2 binds cAMP and cGMP (PubMed:23800469, PubMed:10801446) or not (PubMed:10548487, PubMed:10608844, PubMed:11359771). Its binding to ligand-activated beta-1 adrenergic receptor ADRB1 leads to the Ras activation through the G(s)-alpha signaling pathway. Involved in the cAMP-induced Ras and Erk1/2 signaling pathway that leads to sustained inhibition of long term melanogenesis by reducing dendrite extension and melanin synthesis. Also provides inhibitory signals for cell proliferation of melanoma cells and promotes their apoptosis in a cAMP-independent nanner. Regulates cAMP-induced neuritogenesis by mediating the Rap1/B-Raf/ERK signaling through a pathway that is independent on both PKA and RAPGEF3/RAPGEF4. Involved in neuron migration and in the formation of the major forebrain fiber connections forming the corpus callosum, the anterior commissure and the hippocampal commissure during brain development. Involved in neuronal growth factor (NGF)-induced sustained activation of Rap1 at late endosomes and in brain-derived neurotrophic factor (BDNF)-induced axon outgrowth of hippocampal neurons. Plays a role in the regulation of embryonic blood vessel formation and in the establishment of basal junction integrity and endothelial barrier function. May be involved in the regulation of the vascular endothelial growth factor receptor KDR and cadherin CDH5 expression at allantois endothelial cell-cell junctions., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Members of the RAS (see HRAS; MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF2, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]., [RefSeq]; RAPGEF2 mediates oligomeric Abeta-induced synaptic loss and cognitive dysfunction in the 3xTg-AD mouse model of Alzheimer's disease., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 22,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 50,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A8I5KZ40;D3DP27",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0005509 calcium ion binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0050699 WW domain binding;GO:0030165 PDZ domain binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005923 bicellular tight junction",
        "go_biological_process": "GO:0048022 negative regulation of melanin biosynthetic process;GO:0030033 microvillus assembly;GO:0061028 establishment of endothelial barrier;GO:0032486 Rap protein signal transduction;GO:0007186 G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 13.4,
        "record_id": "Q9Y4G8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UBM8-1",
        "uniprot_id": [
            {
                "id": "MGT4C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UBM8",
                "type": "external"
            }
        ],
        "mass": 56061.0,
        "length": 478,
        "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C",
        "gene_name": "MGAT4C",
        "organism": "Human",
        "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform c",
        "refseq_ac": [
            {
                "id": "NP_037376",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037376",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MGAT4C",
        "gene_names_refseq": "GNTIVH; HGNT-IV-H; MGAT4C",
        "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; 2.4.1.145; GlcNAc-T IVc; GnT-IVc; N-acetylglucosaminyltransferase IV homolog; N-acetylglucosaminyltransferase IVc; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc; hGnT-IV-H",
        "protein_names_refseq": "N-acetylglucosaminyltransferase IV homolog; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVc; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVc; UDP-N-acetylglucosamine:a-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IV-homolog; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C isoform c; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase C; glcNAc-T IVc; gnT-IVc; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme C (putative)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25834);  (R-HSA-9694548);  (R-HSA-975577)",
        "pathway_count": 3,
        "publication_count": 41,
        "publication_id_list": "10395745;10570912;10700233;10766765;10962001;11237011;11421344;11425186;11530204;11588157;11901181;12097641;12603328;12765789;15939404;16434023;16924681;17006639;17021253;1714903;17488527;18931531;19240061;19403558;20117844;22915798;29557506;32363391;32366695;32518941;32676595;33310888;33581268;34117209;34428449;34528721;34599882;34961524;7986008;9054414;9597550",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Association of MGAT4C with major neurocognitive disorder in the Mexican population., [RefSeq, PubMed]; Glycosyltransferase that participates in the transfer of N-acetylglucosamine (GlcNAc) to the core mannose residues of N-linked glycans. Catalyzes the formation of the GlcNAcbeta1-4 branch on the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans. Essential for the production of tri- and tetra-antennary N-linked sugar chains (By similarity). Does not catalyze the transfer of GlcNAc to the Manalpha1-6 arm to form GlcNAcBeta1-4Manalpha1-6 linkage ('GnT-VI' activity)., [UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 668,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DRH2;Q4G199;Q9UIU5",
        "ec_number_list": [
            {
                "id": "2.4.1.155",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.155",
                "type": "external"
            },
            {
                "id": "2.4.1.68",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.68",
                "type": "external"
            },
            {
                "id": "2.4.1.145",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane",
        "go_biological_process": "GO:0019082 viral protein processing;GO:0006487 protein N-linked glycosylation",
        "synthesized_glycan_count": 3884,
        "hit_score": 4.2,
        "record_id": "Q9UBM8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P35749-1",
        "uniprot_id": [
            {
                "id": "MYH11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P35749",
                "type": "external"
            }
        ],
        "mass": 227339.0,
        "length": 1972,
        "protein_name": "Myosin-11",
        "gene_name": "MYH11",
        "organism": "Human",
        "refseq_name": "myosin-11 isoform SM2B",
        "refseq_ac": [
            {
                "id": "NP_001035202",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035202",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYH11; KIAA0866",
        "gene_names_refseq": "AAT4; FAA4; MYH11; SMHC; SMMHC; SMMS-1; VSCM2",
        "protein_names_uniprotkb": "Myosin-11; Myosin heavy chain 11; Myosin heavy chain, smooth muscle isoform; SMMHC",
        "protein_names_refseq": "epididymis secretory sperm binding protein; myosin, heavy chain 11, smooth muscle; myosin, heavy polypeptide 11, smooth muscle; myosin-11 isoform SM2B",
        "tax_id": 9606,
        "disease": "megacystis-microcolon-intestinal hypoperistalsis syndrome (Disease Ontology:DOID:0060610); MYH-9 related disease (Disease Ontology:DOID:0060651); patent ductus arteriosus (Disease Ontology:DOID:13832); thoracic aortic aneurysm (Disease Ontology:DOID:14004); abdominal aortic aneurysm (Disease Ontology:DOID:7693); megacystis-microcolon-intestinal hypoperistalsis syndrome 2 (MONDO:MONDO:0025708); visceral myopathy 2 (MONDO:MONDO:0859157)",
        "pathway": " (hsa:4629);  (R-HSA-3928663);  (R-HSA-416572);  (R-HSA-445355);  (R-HSA-5625740);  (R-HSA-5625900);  (R-HSA-5627117);  (R-HSA-5627123);  (R-HSA-9927432)",
        "pathway_count": 9,
        "publication_count": 170,
        "publication_id_list": "10047984;10092231;10330186;10470034;10619026;10639334;10652353;10748018;10753910;10769020;10924361;10975528;10991994;11018042;11134534;11179879;11237011;11242081;11278486;11313932;11331307;11457814;11532985;11804587;11889009;11942626;12048254;12185584;12196628;12198493;12220504;12453877;12730235;12783890;12802051;14506282;14514689;14580336;14627618;15000491;15003508;15184667;15210733;15377279;15378014;156362;15791647;15848799;16000639;16202622;16204230;16219803;16431929;16444274;16854367;17055381;17081065;17151359;17301291;18006505;18025083;18318008;18452278;18829550;18974361;18991276;19289088;1930128;19380584;19513348;19723632;20068230;20068231;20166139;20444238;21098037;21351730;21749319;22293177;22421042;22544926;22778174;23161543;23301498;23444367;23716662;23834404;24128008;24166499;24275569;24714562;24859002;24872348;2526655;25407000;25418920;25469497;25502872;25880248;26154972;26362469;26758079;26929215;26992070;27397612;27452731;2764880;27679490;28411811;28741090;29351928;29557506;29575632;29632711;2966156;29781137;29786170;29789417;30429286;3079756;31154438;31389005;31427716;31844290;31848261;31944481;32157095;32357974;32387766;32488085;32502341;33091337;33141586;33537174;33912179;33968037;34561969;35008409;35051231;35561310;35580925;36010968;36284347;37217939;37306888;3780718;37938771;3839510;38625590;38773466;7559638;7684189;8107774;8543060;8662509;8702756;8858389;9278512;9354661;9481611;9535855;9598563;9600334;9683637;9792683;9855623;9870942;9870943;9889122;9988689",
        "class_list": "",
        "function": "A harmful MYH11 variant detected in a family with thoracic aortic dissection and patent ductus arteriosus., [RefSeq, PubMed]; Complex genotype-phenotype correlation of MYH11: new insights from monozygotic twins with highly variable expressivity and outcomes. Publication Status: Online-Only, [RefSeq, PubMed]; Genome-wide analysis identifies MYH11 compound heterozygous variants leading to visceral myopathy corresponding to late-onset form of megacystis-microcolon-intestinal hypoperistalsis syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Muscle contraction., [UniProtKB]; The protein encoded by this gene is a smooth muscle myosin belonging to the myosin heavy chain family. The gene product is a subunit of a hexameric protein that consists of two heavy chain subunits and two pairs of non-identical light chain subunits. It functions as a major contractile protein, converting chemical energy into mechanical energy through the hydrolysis of ATP. A chromosomal rearrangement involving this gene is associated with acute myeloid leukemia of the M4Eo subtype. Mutations in this gene are associated with visceral myopathy, megacystis-microcolon-intestinal hypoperistalsis syndrome 2, and familial thoracic aortic aneurysm 4. [provided by RefSeq, May 2022]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 43,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 7,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D2JYH7;O00396;O94944;P78422;Q3MIV8;Q3MNF0;Q3MNF1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0008307 structural constituent of muscle;GO:0000146 microfilament motor activity",
        "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006939 smooth muscle contraction;GO:0031032 actomyosin structure organization;GO:0055013 cardiac muscle cell development;GO:0048251 elastic fiber assembly;GO:0030241 skeletal muscle myosin thick filament assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 17.4,
        "record_id": "P35749-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H1R3-1",
        "uniprot_id": [
            {
                "id": "MYLK2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H1R3",
                "type": "external"
            }
        ],
        "mass": 64685.0,
        "length": 596,
        "protein_name": "Myosin light chain kinase 2, skeletal/cardiac muscle",
        "gene_name": "MYLK2",
        "organism": "Human",
        "refseq_name": "myosin light chain kinase 2, skeletal/cardiac muscle",
        "refseq_ac": [
            {
                "id": "NP_149109",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_149109",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYLK2",
        "gene_names_refseq": "KMLC; MLCK2; MLCK; MYLK2; skMLCK",
        "protein_names_uniprotkb": "Myosin light chain kinase 2, skeletal/cardiac muscle; 2.7.11.18; MLCK2",
        "protein_names_refseq": "myosin light chain kinase 2, skeletal muscle; myosin light chain kinase 2, skeletal/cardiac muscle",
        "tax_id": 9606,
        "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); hypertrophic cardiomyopathy 1 (Disease Ontology:DOID:0110307)",
        "pathway": " (hsa:85366)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11733062;11795875;17344846;24715725;26992070;27726376;29557506;31154438;31530632;31848261;33455984;34000008;35051231;35580925",
        "class_list": "",
        "function": "A novel tumor suppressor role of myosin light chain kinase splice variants through downregulation of the TEAD4/CD44 axis., [RefSeq, PubMed]; Ca(2+)/calmodulin-dependent kinase that phosphorylates the regulatory light chain (RLC) of sarcomeric myosin in skeletal and cardiac muscle. Phosphorylation of RLC promotes displacement of myosin cross-bridges from the thick filament backbone toward actin-containing thin filaments, increasing the probability of cross-bridge entry into force-generating states and thereby potentiating contractile force at submaximal Ca(2+) concentrations., [UniProtKB, UniProtKB, PubMed]; FLNC and MYLK2 Gene Mutations in a Chinese Family with Different Phenotypes of Cardiomyopathy., [RefSeq, PubMed]; This gene encodes a myosin light chain kinase, a calcium/calmodulin dependent enzyme, that is exclusively expressed in adult skeletal muscle. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q569L1;Q96I84",
        "ec_number_list": [
            {
                "id": "2.7.11.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.18",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0004683 calcium/calmodulin-dependent protein kinase activity;GO:0032027 myosin light chain binding;GO:0004687 myosin light chain kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0030017 sarcomere",
        "go_biological_process": "GO:0014816 skeletal muscle satellite cell differentiation;GO:0007165 signal transduction;GO:0010628 positive regulation of gene expression;GO:0046777 protein autophosphorylation;GO:0055008 cardiac muscle tissue morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.5,
        "record_id": "Q9H1R3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N488-1",
        "uniprot_id": [
            {
                "id": "RYBP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N488",
                "type": "external"
            }
        ],
        "mass": 24822.0,
        "length": 228,
        "protein_name": "RING1 and YY1-binding protein",
        "gene_name": "RYBP",
        "organism": "Human",
        "refseq_name": "RING1 and YY1-binding protein",
        "refseq_ac": [
            {
                "id": "NP_036366",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036366",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RYBP; DEDAF; YEAF1",
        "gene_names_refseq": "AAP1; APAP-1; DEDAF; RYBP; YEAF1",
        "protein_names_uniprotkb": "RING1 and YY1-binding protein; APAP-1; Apoptin-associating protein 1; DED-associated factor; Death effector domain-associated factor; YY1 and E4TF1-associated factor 1",
        "protein_names_refseq": "DED-associated factor; RING1 and YY1-binding protein; YY1 and E4TF1 associated factor 1; apoptin-associating protein 1; death effector domain-associated factor; ring1 interactor RYBP",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23429);  (R-HSA-8939243);  (R-HSA-8953750)",
        "pathway_count": 3,
        "publication_count": 59,
        "publication_id_list": "11171983;11395500;11953439;12004135;12411495;12909625;14765135;15014447;15536069;16917507;16943429;17001316;17600109;18452278;18562691;18669648;18695000;19098711;19413330;19651622;19664995;19690332;20068231;20506188;20696397;21406692;21596310;22325351;23186163;23954429;24627085;24715725;25519132;25892735;26687479;27060496;27748911;28218747;28832583;28904123;29242379;29437277;29557506;29769354;30429286;31844290;31848261;32157095;33592498;33912179;35051231;37272752;38528151;38735205;38785968;7623816;9501179;9689056;9704927",
        "class_list": "",
        "function": "Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1-like complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility (PubMed:25519132). Component of a PRC1-like complex that mediates monoubiquitination of histone H2A 'Lys-119' on the X chromosome and is required for normal silencing of one copy of the X chromosome in XX females. May stimulate ubiquitination of histone H2A 'Lys-119' by recruiting the complex to target sites (By similarity). Inhibits ubiquitination and subsequent degradation of TP53, and thereby plays a role in regulating transcription of TP53 target genes (PubMed:19098711). May also regulate the ubiquitin-mediated proteasomal degradation of other proteins like FANK1 to regulate apoptosis (PubMed:14765135, PubMed:27060496). May be implicated in the regulation of the transcription as a repressor of the transcriptional activity of E4TF1 (PubMed:11953439). May bind to DNA (By similarity). May play a role in the repression of tumor growth and metastasis in breast cancer by down-regulating SRRM3 (PubMed:27748911)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Deficiency of the Polycomb Protein RYBP and TET Methylcytosine Oxidases Promotes Extensive CpG Island Hypermethylation and Malignant Transformation., [RefSeq, PubMed]; Glucose-induced RYBP suppresses tumor cell aerobic glycolysis and migration., [RefSeq, PubMed]; Interacts specifically with the E2F2 and E2F3 family members, dependent on the marked box domain in these proteins, [RefSeq, PubMed]; Structural basis of the histone ubiquitination read-write mechanism of RYBP-PRC1. Erratum:[Nat Struct Mol Biol. 2025 Sep;32(9):1840. doi: 10.1038/s41594-025-01674-7. PMID: 40866579], [RefSeq, PubMed]; Unveiling the Binding between the Armadillo-Repeat Domain of Plakophilin 1 and the Intrinsically Disordered Transcriptional Repressor RYBP. Publication Status: Online-Only, [RefSeq, PubMed]; YEAF1/RYBP and YAF-2 are functionally distinct members of a cofactor family for the YY1 and E4TF1/hGABP transcription factors., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 13,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9P2W5;Q9UMW4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003714 transcription corepressor activity;GO:0003676 nucleic acid binding;GO:0003712 transcription coregulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0031519 PcG protein complex",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0043065 positive regulation of apoptotic process;GO:0006355 regulation of DNA-templated transcription;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.0,
        "record_id": "Q8N488-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NEX5-1",
        "uniprot_id": [
            {
                "id": "WFDC9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NEX5",
                "type": "external"
            }
        ],
        "mass": 10506.0,
        "length": 89,
        "protein_name": "Protein WFDC9",
        "gene_name": "WFDC9",
        "organism": "Human",
        "refseq_name": "protein WFDC9 precursor",
        "refseq_ac": [
            {
                "id": "NP_671731",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671731",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "WFDC9; WAP9",
        "gene_names_refseq": "WAP9; WFDC9; dJ688G8.2",
        "protein_names_uniprotkb": "Protein WFDC9",
        "protein_names_refseq": "protein WFDC9 precursor; protein WFDC9",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:259240)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "12206714;24715725",
        "class_list": "",
        "function": "The WAP-type four-disulfide core (WFDC) domain, or WAP signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many members of the WFDC domain family. This gene encodes a protein which contains a WFDC domain, and is thus a member of the WFDC domain family. This gene and several other gene family members are clustered at 20q13.12. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3MIX6;Q5TGZ8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q8NEX5-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P21741-1",
        "uniprot_id": [
            {
                "id": "MK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P21741",
                "type": "external"
            }
        ],
        "mass": 15585.0,
        "length": 143,
        "protein_name": "Midkine",
        "gene_name": "MDK",
        "organism": "Human",
        "refseq_name": "midkine isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001012333",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012333",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MDK; MK1; NEGF2",
        "gene_names_refseq": "ARAP; MDK; MK; NEGF2",
        "protein_names_uniprotkb": "Midkine; ARAP; Amphiregulin-associated protein; MK; Midgestation and kidney protein; Neurite outgrowth-promoting factor 2; Neurite outgrowth-promoting protein",
        "protein_names_refseq": "amphiregulin-associated protein; midgestation and kidney protein; midkine isoform a precursor; neurite growth-promoting factor 2; neurite outgrowth-promoting factor 2; retinoic acid inducible factor",
        "tax_id": 9606,
        "disease": "brain ischemia (Disease Ontology:DOID:2316); endometriosis (Disease Ontology:DOID:289); brain infarction (Disease Ontology:DOID:3454); coronary stenosis (Disease Ontology:DOID:4248); schizophrenia (Disease Ontology:DOID:5419); myocardial infarction (Disease Ontology:DOID:5844)",
        "pathway": " (hsa:4192);  (R-HSA-201556);  (R-HSA-2979096);  (R-HSA-9851151)",
        "pathway_count": 4,
        "publication_count": 141,
        "publication_id_list": "10.1038/emboj.2013.79;10206645;10212223;10551863;10683378;10772929;10934472;10958687;11110708;11121404;11171333;11237011;11278720;11280786;11518718;11607835;11740940;11751994;11823422;11850821;11861489;12084985;12107166;12122009;12147681;12209127;12424201;12530964;12573468;12934099;14563642;14567914;14962911;15226403;15317731;15340161;15374880;15466886;15569487;15588951;15592455;15760269;15824097;15829515;15895073;15938644;16093323;16153455;16170336;16317043;1639750;16773578;16814777;16825495;16871283;16878150;16939498;17003037;17086210;17185414;17274988;17353907;17379400;17681947;1768439;18043734;18070884;18077452;18097461;1840698;18418349;18469519;18724359;1883381;18923524;18990089;19459784;20156974;2025291;20632993;20719933;21154129;21345110;21632553;22162641;22286764;22323540;22439933;22658935;22658936;23201355;23239810;23584533;23777859;23889739;24060861;24356251;24458438;24670165;24736079;24842903;24947326;25331893;25342631;25421750;25576301;26418745;26464158;26630010;26708155;26896299;27445335;27780853;29380702;29455642;29856954;29856955;29873274;29964125;30061385;30692217;3153318;31585938;32350084;34646012;34819673;35008303;35251023;38947322;40930100;803282;8241100;8471163;8633037;9207787;9207788;9384573;9604939;9620803;9651681;9819383",
        "class_list": "glycogene",
        "function": "Secreted protein that functions as a cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors (PubMed:10212223, PubMed:10772929, PubMed:12084985, PubMed:12122009, PubMed:12573468, PubMed:15466886, PubMed:18469519, PubMed:24458438). Binds cell-surface proteoglycan receptors via their chondroitin sulfate (CS) groups (PubMed:10212223, PubMed:12084985). Thereby regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration (PubMed:10212223, PubMed:10683378, PubMed:10772929, PubMed:12084985, PubMed:12122009, PubMed:12573468, PubMed:15466886, PubMed:22323540, PubMed:24458438). Participates in inflammatory processes by exerting two different activities. Firstly, mediates neutrophils and macrophages recruitment to the sites of inflammation both by direct action by cooperating namely with ITGB2 via LRP1 and by inducing chemokine expression (PubMed:10683378, PubMed:24458438). This inflammation can be accompanied by epithelial cell survival and smooth muscle cell migration after renal and vessel damage, respectively (PubMed:10683378). Secondly, suppresses the development of tolerogenic dendric cells thereby inhibiting the differentiation of regulatory T cells and also promote T cell expansion through NFAT signaling and Th1 cell differentiation (PubMed:22323540). Promotes tissue regeneration after injury or trauma. After heart damage negatively regulates the recruitment of inflammatory cells and mediates cell survival through activation of anti-apoptotic signaling pathways via MAPKs and AKT pathways through the activation of angiogenesis (By similarity). Also facilitates liver regeneration as well as bone repair by recruiting macrophage at trauma site and by promoting cartilage development by facilitating chondrocyte differentiation (By similarity). Plays a role in brain by promoting neural precursor cells survival and growth through interaction with heparan sulfate proteoglycans (By similarity). Binds PTPRZ1 and promotes neuronal migration and embryonic neurons survival (PubMed:10212223). Binds SDC3 or GPC2 and mediates neurite outgrowth and cell adhesion (PubMed:12084985, PubMed:1768439). Binds chondroitin sulfate E and heparin leading to inhibition of neuronal cell adhesion induced by binding with GPC2 (PubMed:12084985). Binds CSPG5 and promotes elongation of oligodendroglial precursor-like cells (By similarity). Also binds ITGA6:ITGB1 complex; this interaction mediates MDK-induced neurite outgrowth (PubMed:15466886, PubMed:1768439). Binds LRP1; promotes neuronal survival (PubMed:10772929). Binds ITGA4:ITGB1 complex; this interaction mediates MDK-induced osteoblast cells migration through PXN phosphorylation (PubMed:15466886). Binds anaplastic lymphoma kinase (ALK) which induces ALK activation and subsequent phosphorylation of the insulin receptor substrate (IRS1), followed by the activation of mitogen-activated protein kinase (MAPK) and PI3-kinase, and the induction of cell proliferation (PubMed:12122009). Promotes epithelial to mesenchymal transition through interaction with NOTCH2 (PubMed:18469519). During arteriogenesis, plays a role in vascular endothelial cell proliferation by inducing VEGFA expression and release which in turn induces nitric oxide synthase expression. Moreover activates vasodilation through nitric oxide synthase activation (By similarity). Negatively regulates bone formation in response to mechanical load by inhibiting Wnt/beta-catenin signaling in osteoblasts (By similarity). In addition plays a role in hippocampal development, working memory, auditory response, early fetal adrenal gland development and the female reproductive system (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Secreted protein that functions as cytokine and growth factor and mediates its signal through cell-surface proteoglycan and non-proteoglycan receptors. Regulates many processes like inflammatory response, cell proliferation, cell adhesion, cell growth, cell survival, tissue regeneration, cell differentiation and cell migration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. [provided by RefSeq, Jul 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 183,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 6,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2LEK4;Q9UCC7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008201 heparin binding;GO:1904399 heparan sulfate binding;GO:0008083 growth factor activity;GO:0035374 chondroitin sulfate binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0042995 cell projection",
        "go_biological_process": "GO:2000347 positive regulation of hepatocyte proliferation;GO:1905564 positive regulation of vascular endothelial cell proliferation;GO:1904996 positive regulation of leukocyte adhesion to vascular endothelial cell;GO:1904036 negative regulation of epithelial cell apoptotic process;GO:0021681 cerebellar granular layer development",
        "synthesized_glycan_count": 0,
        "hit_score": 14.7,
        "record_id": "P21741-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NB16-1",
        "uniprot_id": [
            {
                "id": "MLKL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NB16",
                "type": "external"
            }
        ],
        "mass": 54479.0,
        "length": 471,
        "protein_name": "Mixed lineage kinase domain-like protein",
        "gene_name": "MLKL",
        "organism": "Human",
        "refseq_name": "mixed lineage kinase domain-like protein isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001135969",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135969",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MLKL",
        "gene_names_refseq": "MLKL; hMLKL",
        "protein_names_uniprotkb": "Mixed lineage kinase domain-like protein; hMLKL",
        "protein_names_refseq": "mixed lineage kinase domain-like protein isoform 2; mixed lineage kinase domain-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:197259);  (R-HSA-168276);  (R-HSA-3295583);  (R-HSA-5213460);  (R-HSA-5675482);  (R-HSA-9686347)",
        "pathway_count": 6,
        "publication_count": 116,
        "publication_id_list": "10205180;10846107;11050376;11226139;11237011;11243859;11301059;12015988;12471243;1422598;14634208;16282325;17344846;17644308;18570872;18669648;18691976;18991276;19524512;19524513;19844255;20025796;20068231;20716668;21737330;22265413;22265414;22421439;22817896;24059293;24095729;24219132;24316671;24703947;24715725;24813885;24901049;25389312;25674983;25765567;25852146;25855297;25996294;26184911;26559832;26768311;26775703;26866270;26900751;26933192;26992070;27362805;27600516;27920218;28661484;28832583;29104146;29237092;29242379;29393594;29493099;29557506;29681455;29883609;29883610;29930286;30157175;30185776;30355688;30429286;30484775;30770249;30833945;31031142;31138766;31154438;31217245;31358971;31727943;31839993;31844290;31848261;31914150;32157095;32161166;32269263;32350084;32357974;32387766;32561730;32690704;32897882;32938616;33298915;33912179;33968037;34171305;34405274;34509645;34561969;34932366;34999730;35051231;35580925;36215666;36241641;36284347;37996483;38041169;38783090;38862702;39059047;40596516;40914422;8313914;9651582",
        "class_list": "",
        "function": "Death at a funeral: Activation of the dead enzyme, MLKL, to kill cells by necroptosis. Review article, [RefSeq, PubMed]; Findings implicate MLKL as a key mediator of necrosis signaling downstream of the kinase RIP3., [RefSeq, PubMed]; MLKL deficiency alleviates neuroinflammation and motor deficits in the alpha-synuclein transgenic mouse model of Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]; MLKL polymerization-induced lysosomal membrane permeabilization promotes necroptosis., [RefSeq, PubMed]; MLKL promotes hepatocarcinogenesis through inhibition of AMPK-mediated autophagy., [RefSeq, PubMed]; MLKL regulates radiation-induced death in breast cancer cells: an interplay between apoptotic and necroptotic signals. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Pseudokinase that plays a key role in TNF-induced necroptosis, a programmed cell death process (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Does not have protein kinase activity (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). Activated following phosphorylation by RIPK3, leading to homotrimerization, localization to the plasma membrane and execution of programmed necrosis characterized by calcium influx and plasma membrane damage (PubMed:22265413, PubMed:22265414, PubMed:22421439, PubMed:24316671). In addition to TNF-induced necroptosis, necroptosis can also take place in the nucleus in response to orthomyxoviruses infection: following activation by ZBP1, MLKL is phosphorylated by RIPK3 in the nucleus, triggering disruption of the nuclear envelope and leakage of cellular DNA into the cytosol.following ZBP1 activation, which senses double-stranded Z-RNA structures, nuclear RIPK3 catalyzes phosphorylation and activation of MLKL, promoting disruption of the nuclear envelope and leakage of cellular DNA into the cytosol (By similarity). Binds to highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which is essential for its necroptotic function (PubMed:29883610)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Study suggests that MLKL is a key RIP3 downstream component of TNF-induced necrotic cell death, [RefSeq, PubMed]; This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NCE4;Q8N6V0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004672 protein kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0051607 defense response to virus;GO:0070207 protein homotrimerization;GO:0097527 necroptotic signaling pathway;GO:0070266 necroptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "Q8NB16-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q969S2-1",
        "uniprot_id": [
            {
                "id": "NEIL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q969S2",
                "type": "external"
            }
        ],
        "mass": 36826.0,
        "length": 332,
        "protein_name": "Endonuclease 8-like 2",
        "gene_name": "NEIL2",
        "organism": "Human",
        "refseq_name": "endonuclease 8-like 2 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001129218",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129218",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NEIL2",
        "gene_names_refseq": "NEH2; NEI2; NEIL2",
        "protein_names_uniprotkb": "Endonuclease 8-like 2; 3.2.2.-; 4.2.99.18; DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; Endonuclease VIII-like 2; NEH2; Nei homolog 2; Nei-like protein 2",
        "protein_names_refseq": "DNA glycosylase/AP lyase Neil2; DNA-(apurinic or apyrimidinic site) lyase Neil2; endonuclease 8-like 2 isoform a; endonuclease 8-like 2; nei endonuclease VIII-like 2; nei homolog 2; nei-like protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:252969);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-5649702)",
        "pathway_count": 4,
        "publication_count": 52,
        "publication_id_list": "10074426;10882850;10930409;11056019;11163244;11237011;11904416;12097317;12140329;12200441;12456671;12718543;14522990;14734554;15175427;15260972;15339932;15341901;16221681;16982218;21722948;22569481;22848106;22962365;23186163;25418920;26095805;27354518;29242379;29393594;30410026;30429286;31154438;31844290;31848261;32157095;32357974;33691108;34171305;34561969;35051231;35216329;36215666;37310399;37971311;38071370;8218289;8407958;8662714;9705289;9811839;9890904",
        "class_list": "",
        "function": "A Low-Activity Polymorphic Variant of Human NEIL2 DNA Glycosylase. Publication Status: Online-Only, [RefSeq, PubMed]; Functional roles and cancer variants of the bifunctional glycosylase NEIL2. Review article, [RefSeq, PubMed]; HNEIL2 recognized an apurinic/apyrimidinic site exclusively, and the activity for 5-hydroxyuracil and guanine-derived formamidopyrimidine was marginal, [RefSeq, PubMed]; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Has DNA glycosylase activity towards 5-hydroxyuracil and other oxidized derivatives of cytosine with a preference for mismatched double-stranded DNA (DNA bubbles). Has low or no DNA glycosylase activity towards thymine glycol, 2-hydroxyadenine, hypoxanthine and 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; NEIL1 and NEIL2 are preferentially involved in repair of lesions in DNA bubbles generated during transcription and/or replication, [RefSeq, PubMed]; NEIL2 is involved in global genome repair mainly for removing oxidative products of cytosine., [RefSeq, PubMed]; Structural and biochemical insights into NEIL2's preference for abasic sites., [RefSeq, PubMed]; The DNA glycosylase NEIL2 is protective during SARS-CoV-2 infection. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the Fpg/Nei family of DNA glycosylases. These glycosylases initiate the first step in base excision repair by cleaving oxidatively damaged bases and introducing a DNA strand break via their abasic site lyase activity. This enzyme is primarily associated with DNA repair during transcription and acts prefentially on cytosine-derived lesions, particularly 5-hydroxyuracil and 5-hydroxycytosine. It contains an N-terminal catalytic domain, a hinge region, and a C-terminal DNA-binding domain with helix-two-turn-helix and zinc finger motifs. This enzyme interacts with the X-ray cross complementing factor 1 scaffold protein as part of a multi-protein DNA repair complex. A pseudogene of this gene has been identified. [provided by RefSeq, Mar 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DFR7;Q7Z3Q7;Q8N842;Q8NG52",
        "ec_number_list": [
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "3.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "4.2.99.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "6.5.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1",
                "type": "external"
            },
            {
                "id": "1.14.11.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51",
                "type": "external"
            },
            {
                "id": "1.14.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-",
                "type": "external"
            },
            {
                "id": "1.14.11.33",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008017 microtubule binding;GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0019104 DNA N-glycosylase activity;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0072686 mitotic spindle",
        "go_biological_process": "GO:0045008 depyrimidination",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q969S2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H871-1",
        "uniprot_id": [
            {
                "id": "RMD5A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H871",
                "type": "external"
            }
        ],
        "mass": 43993.0,
        "length": 391,
        "protein_name": "E3 ubiquitin-protein transferase RMND5A",
        "gene_name": "RMND5A",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein transferase RMND5A",
        "refseq_ac": [
            {
                "id": "NP_073617",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073617",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RMND5A",
        "gene_names_refseq": "CTLH; GID2A; GID2; RMD5; RMND5A; p44CTLH",
        "protein_names_uniprotkb": "E3 ubiquitin-protein transferase RMND5A; 2.3.2.27; P44CTLH; Protein RMD5 homolog A",
        "protein_names_refseq": "44-kD protein coding for CTLH motif; C-terminal to LisH motif, 44 kDa; E3 ubiquitin-protein transferase RMND5A; GID complex subunit 2 homolog A; protein RMD5 homolog A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64795);  (R-HSA-9861718)",
        "pathway_count": 2,
        "publication_count": 69,
        "publication_id_list": "17467196;18387606;22499340;22681319;23271734;23481700;24057215;24143168;24366607;24715725;25418920;25793641;25880248;26154972;26992070;27846572;27920218;28063628;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29508533;29557506;29632046;29632711;29786170;29789417;29911972;30315122;30429286;30524438;30779550;30833945;31092671;31154438;31530632;31735643;31844290;31848261;32157095;32161166;32265295;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33462636;33717175;33912179;33936100;33981976;34019948;34932366;35051231;35580925;36010968;36284347;36828188;37938771;38759627;7757881",
        "class_list": "",
        "function": "Core component of the CTLH E3 ubiquitin-protein ligase complex that selectively accepts ubiquitin from UBE2H and mediates ubiquitination and subsequent proteasomal degradation of the transcription factor HBP1. MAEA and RMND5A are both required for catalytic activity of the CTLH E3 ubiquitin-protein ligase complex (PubMed:29911972). Catalytic activity of the complex is required for normal cell proliferation (PubMed:29911972). The CTLH E3 ubiquitin-protein ligase complex is not required for the degradation of enzymes involved in gluconeogenesis, such as FBP1 (PubMed:29911972)., [UniProtKB, PubMed]; Duplications of this region involving RMND5A, whose product contains a C-terminal to lis homology (LisH) domain, have not previously been associated with a defined phenotype but may present insight into encephalocele formation., [RefSeq, PubMed]; GID2 Interacts With CDKN3 and Regulates Pancreatic Cancer Growth and Apoptosis., [RefSeq, PubMed]; Non-canonical substrate recognition by the human WDR26-CTLH E3 ligase regulates prodrug metabolism., [RefSeq, PubMed]; RanBPM, ARMC8alpha, ARMC8beta, Muskelin, p48EMLP, and p44CTLH form complexes in cells., [RefSeq, PubMed]; The study identifies a miR-138-RMND5A-Exportin-5 as a previously unknown miRNA processing regulatory pathway in HeLa cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6W5M6;Q6NTF0;Q9H6W5;Q9H9H2",
        "ec_number_list": [
            {
                "id": "1.1.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.27",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0000151 ubiquitin ligase complex",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0000209 protein polyubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q9H871-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q3V5L5-1",
        "uniprot_id": [
            {
                "id": "MGT5B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q3V5L5",
                "type": "external"
            }
        ],
        "mass": 89535.0,
        "length": 792,
        "protein_name": "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B",
        "gene_name": "MGAT5B",
        "organism": "Human",
        "refseq_name": "alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001186101",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186101",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MGAT5B; KIAA2008",
        "gene_names_refseq": "GnT-IX; GnT-VB; MGAT5B",
        "protein_names_uniprotkb": "Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B; 2.4.1.-; 2.4.1.155; Alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B; GNT-IX; GNT-Vb; GlcNAc-T Vb; Mannoside acetylglucosaminyltransferase 5B; N-acetylglucosaminyl-transferase Vb; N-acetylglucosaminyltransferase IX; hGnTVb",
        "protein_names_refseq": "N-acetylglucosaminyl-transferase Vb; N-acetylglucosaminyltransferase IX; alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B isoform 3; alpha-mannoside beta-1,6-N-acetylglucosaminyltransferase B; beta(1,6)-N-acetylglucosaminyltransferase V; glcNAc-T Vb; hGnTVb; mannoside acetylglucosaminyltransferase 5B; mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isoenzyme B; mannosyl (alpha-1,6-)-glycoprotein beta-1,6-N-acetyl-glucosaminyltransferase, isozyme B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:146664);  (R-HSA-8932504)",
        "pathway_count": 2,
        "publication_count": 32,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11709191;12369018;12941944;14561752;14617637;14623122;14699049;15792865;16413118;16575835;16606368;16857188;19846580;22172424;23329833;23960081;25892735;27600516;27659420;29393594;30833945;32157095;32350084;32387766;33592498;35251023;36215666;36240223;36241641;37543361",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Brain-specific glycosylation enzyme GnT-IX maintains levels of protein tyrosine phosphatase receptor PTPRZ, thereby mediating glioma growth., [RefSeq, PubMed]; ENPP3 is a regulator of N-acetylglucosaminyltransferase GnT-IX (GnT-Vb), [RefSeq, PubMed]; Following human GnT-IX and GnT-V transfection in COS cells, antibody specifically recognized GnT-IX, but not GnT-V, in the Golgi apparatus, [RefSeq, PubMed]; Glycosyltransferase that acts on alpha-linked mannose of N-glycans and O-mannosyl glycans. Catalyzes the transfer of N-acetylglucosamine (GlcNAc) to the beta 1-6 linkage of the mannose residue of GlcNAc-beta1,2-Man-alpha on both the alpha1,3- and alpha1,6-linked mannose arms in the core structure of N-glycan. Also acts on the GlcNAc-beta1,2-Man-alpha1-Ser/Thr moiety, forming a 2,6-branched structure in brain O-mannosyl glycan. Plays an active role in modulating integrin and laminin-dependent adhesion and migration of neuronal cells via its activity in the O-mannosyl glycan pathway., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; GnT-IX is responsible for the synthesis of a unique oligosaccharide structure in the brain, [RefSeq, PubMed]; N-linked beta(1,6) branching has a role in cell-cell adhesion, cellular motility and neoplasm invasiveness, [RefSeq, PubMed]; We found a strong correlation between serum GnT-V activity and HDL-C concentration in human subjects, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 915,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6P3S8;Q6P6B3;Q766X5;Q76D04;Q96LS2",
        "ec_number_list": [
            {
                "id": "2.4.1.155",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.155",
                "type": "external"
            },
            {
                "id": "2.4.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0030145 manganese ion binding;GO:0030144 alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0006493 protein O-linked glycosylation;GO:0006487 protein N-linked glycosylation",
        "synthesized_glycan_count": 2931,
        "hit_score": 4.4,
        "record_id": "Q3V5L5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000000.100.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BWT6-1",
        "uniprot_id": [
            {
                "id": "MND1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BWT6",
                "type": "external"
            }
        ],
        "mass": 23753.0,
        "length": 205,
        "protein_name": "Meiotic nuclear division protein 1 homolog",
        "gene_name": "MND1",
        "organism": "Human",
        "refseq_name": "meiotic nuclear division protein 1 homolog isoform 1",
        "refseq_ac": [
            {
                "id": "NP_115493",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115493",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MND1; GAJ",
        "gene_names_refseq": "GAJ; MND1",
        "protein_names_uniprotkb": "Meiotic nuclear division protein 1 homolog",
        "protein_names_refseq": "homolog of yeast MND1; meiotic nuclear division protein 1 homolog isoform 1; meiotic nuclear division protein 1 homolog; meiotic nuclear divisions 1 homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84057);  (R-HSA-912446)",
        "pathway_count": 2,
        "publication_count": 75,
        "publication_id_list": "10029069;10438626;10562567;10728666;10734115;10928988;11237011;11292842;15164066;15304223;16123081;16292313;16322221;16407260;17541404;17965729;17977839;17981954;18256600;18535008;20044539;20044541;20062530;20818382;22645359;23481700;23675907;24366607;24714562;24715725;25418920;25576301;26375851;26728094;26992070;27600516;27846572;27920218;28832583;28834231;28904123;29242379;29393594;29493099;29608566;29632046;30379171;30524438;31217245;31844290;32157095;32265295;32357974;32387766;32502341;32897882;32938616;33592498;33633747;33691108;33717175;33912179;33936100;33941804;33968037;34211107;36010968;36098680;40596516;8929543;9008167;9311981;9450758;9781043;9826763",
        "class_list": "",
        "function": "Data indicate that the positive expression of studied genes fertilization rate for GAPDHS positive subset was 66%, ACR - 71%, SPATA22 - 68%, MND1 - 70%, pregnancy rates were 8%, 6%, 18% and 36% respectively. Publication Status: Online-Only, [RefSeq, PubMed]; Data suggest that the human TBPIP/Hop2-Mnd1 complex may ensure proper pairing between homologous chromosomes through its stimulation of strand exchange during meiosis., [RefSeq, PubMed]; Genetic network and gene set enrichment analyses identify MND1 as potential diagnostic and therapeutic target gene for lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; MND1 functions as a potential prognostic biomarker associated with cell cycle and immune infiltration in kidney renal clear cell carcinoma., [RefSeq, PubMed]; Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed]; The product of the MND1 gene associates with HOP2 (MIM 608665) to form a stable heterodimeric complex that binds DNA and stimulates the recombinase activity of RAD51 (MIM 179617) and DMC1 (MIM 602721) (Chi et al., 2007 [PubMed 17639080]). Both the MND1 and HOP2 genes are indispensable for meiotic recombination.[supplied by OMIM, Mar 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R5F9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003690 double-stranded DNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0007129 homologous chromosome pairing at meiosis;GO:0007131 reciprocal meiotic recombination",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q9BWT6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q02505-1",
        "uniprot_id": [
            {
                "id": "MUC3A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q02505",
                "type": "external"
            }
        ],
        "mass": 345127.0,
        "length": 3323,
        "protein_name": "Mucin-3A",
        "gene_name": "MUC3A",
        "organism": "Human",
        "refseq_name": "mucin-3A precursor",
        "refseq_ac": [
            {
                "id": "NP_005951",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005951",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MUC3A; MUC3",
        "gene_names_refseq": "MUC-3A; MUC3A; MUC3",
        "protein_names_uniprotkb": "Mucin-3A; Intestinal mucin-3A; MUC-3A",
        "protein_names_refseq": "intestinal mucin; mucin 3, intestinal; mucin-3A precursor; mucin-3A",
        "tax_id": 9606,
        "disease": "small intestine carcinoid neuroendocrine tumor (Disease Ontology:DOID:0050925); pancreatic ductal carcinoma (Disease Ontology:DOID:3587); cholangiocarcinoma (Disease Ontology:DOID:4947)",
        "pathway": " (hsa:4584);  (R-HSA-5083625);  (R-HSA-5083632);  (R-HSA-5083636);  (R-HSA-5621480);  (R-HSA-913709);  (R-HSA-977068)",
        "pathway_count": 7,
        "publication_count": 78,
        "publication_id_list": "10330415;10405327;10430883;10504389;10512748;10742600;10753916;11042166;11062056;11110698;11237011;11283017;11289722;11304796;11606584;11821425;12464682;12855678;12958310;1329093;14656219;15466199;15486459;15560372;15599692;15620693;15687324;16151858;16251947;16319059;17050534;17113861;18490740;18537974;18776906;18818202;19617566;21880719;22041900;22183981;22461326;23053572;23507963;23602766;2373995;2393399;24643043;25153226;27600516;28514659;29393594;31844290;32387766;32938616;32983136;34087483;34171305;34932366;35051231;35655161;36010968;36284347;38069509;38253038;7655172;8333853;8598452;8611500;8920913;8972730;9042338;9295285;9334251;9394011;9417100;9435216;9915862;9988682",
        "class_list": "",
        "function": "Decoding the expression pattern of MUC3A in gastric adenocarcinoma: unveiling the key to successful immunotherapy., [RefSeq, PubMed]; Has highly conserved amino and carboxyl termini, suggesting a recent duplication of the entire ancestral gene, [RefSeq, PubMed]; MUC3A promotes the progression of colorectal cancer through the PI3K/Akt/mTOR pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Major glycoprotein component of a variety of mucus gels. Thought to provide a protective, lubricating barrier against particles and infectious agents at mucosal surfaces. May be involved in ligand binding and intracellular signaling., [UniProtKB, PubMed]; The mucin genes encode epithelial glycoproteins, some of which are secreted and some membrane bound. Each of the genes contains at least one large domain of tandemly repeated sequence that encodes the peptide sequence rich in serine and/or threonine residues, which carries most of the O-linked glycosylation (Gendler and Spicer, 1995 [PubMed 7778880]).[supplied by OMIM, Aug 2008]., [RefSeq]",
        "predicted_glycosites": 14,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 14,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 21,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 21,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 21,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 261,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 35,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NP22;O14650;O14651;O43418;O43421;Q02506;Q6W763;Q9H3Q7;Q9UKW9;Q9UN93;Q9UN94;Q9UN95",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005201 extracellular matrix structural constituent;GO:0030197 extracellular matrix constituent, lubricant activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005796 Golgi lumen;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 10.1,
        "record_id": "Q02505-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.001000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UM21-1",
        "uniprot_id": [
            {
                "id": "MGT4A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UM21",
                "type": "external"
            }
        ],
        "mass": 61544.0,
        "length": 535,
        "protein_name": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A",
        "gene_name": "MGAT4A",
        "organism": "Human",
        "refseq_name": "alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001153626",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153626",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MGAT4A",
        "gene_names_refseq": "GNT-IVA; GNT-IV; GnT-4a; MGAT4A",
        "protein_names_uniprotkb": "Alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A; 2.4.1.145; GlcNAc-T IVa; GnT-IVa; N-acetylglucosaminyltransferase IVa; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa",
        "protein_names_refseq": "N-acetylglucosaminyltransferase IVa; N-glycosyl-oligosaccharide-glycoprotein N-acetylglucosaminyltransferase IVa; UDP-GlcNAc:a-1,3-D-mannoside b-1,4-acetylglucosaminyltransferase IV; UDP-N-acetylglucosamine: alpha-1,3-D-mannoside beta-1,4-N-acetylglucosaminyltransferase IVa; UDP-N-acetylglucosamine:alpha1,3-d-mannoside beta1,4-N-acetylglucosaminyltransferase; alpha-1,3-mannosyl-glycoprotein 4-beta-N-acetylglucosaminyltransferase A isoform 2; alpha-1,3-mannosyl-glycoprotein beta-1,4-N-acetylglucosaminyltransferase; glcNAc-T IVa; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isoenzyme A; mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetylglucosaminyltransferase, isozyme A",
        "tax_id": 9606,
        "disease": "pancreatic cancer (Disease Ontology:DOID:1793)",
        "pathway": " (hsa:11320);  (R-HSA-381426);  (R-HSA-8957275);  (R-HSA-9694548);  (R-HSA-975577)",
        "pathway_count": 5,
        "publication_count": 128,
        "publication_id_list": "10024668;10026136;10077652;10218588;10395745;10463590;10512690;10570912;10614670;10681634;10700233;10766765;10810289;10898936;10912521;10951195;10990447;11158056;11237011;11250653;11264294;11316783;11421344;11425186;11522292;11530204;11588157;11606061;11739083;11751371;11788658;11901181;12097641;12241545;12379487;12466191;12603328;12765789;12810533;12904166;1370451;1383255;15126567;15308688;15469690;15485880;15525596;15642270;15688387;15939404;16434023;16924681;17006639;17021253;17047378;1714903;17249697;17312271;17488527;17985932;18931531;19403558;20117844;22915798;23090970;23169300;24190977;2476804;2479552;25576301;26091039;26589799;28534963;28904123;29242379;29393594;29786170;30573663;31844290;32157095;32357974;32363391;32366695;32387766;32518941;32676595;32938616;32983136;33043033;33310888;33392160;33592498;33912179;33968037;34117209;34357683;34428449;34528721;34599882;34961524;35051231;35154160;35580925;37295747;40307207;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7683646;7689487;7986008;8781553;8817670;8894645;8964575;9054414;9497324;9597550;9709957;9733769;9786878;9922210",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Analysis of expression of N-acetylglucosaminyltransferase-IVa and IVb (GnT-IVa and b) in pancreatic cancer, [RefSeq, PubMed]; Data suggest microRNA-424 regulates expression of MGAT4A (mannoside beta-1,4-N-acetylglucosaminyltransferase A), OGT (O-linked N-acetylglucosamine transferase), and GALNT13 (polypeptide N-acetylgalactosaminyltransferase 13) in mammary epithelium., [RefSeq, PubMed]; Findings suggest that GnT-IVa is involved in regulating invasion of choriocarcinoma through modifications of the oligosaccharide chains of beta1 integrin., [RefSeq, PubMed]; Glycosyltransferase that catalyze the transfer of GlcNAc from UDP-GlcNAc to the GlcNAcbeta1-2Manalpha1-3 arm of the core structure of N-linked glycans through a beta1-4 linkage and participates in the production of tri- and tetra-antennary N-linked sugar chains (PubMed:17006639). Involved in glucose transport by mediating SLC2A2/GLUT2 glycosylation, thereby controlling cell-surface expression of SLC2A2 in pancreatic beta cells (By similarity)., [UniProtKB, PubMed, UniProtKB]; GnT-IVa is more active than GnT-IVb under physiological conditions and it primarily contributes to the biosynthesis of N-glycans., [RefSeq, PubMed]; GnT-IVa may contribute to the malignancy of choriocarcinoma by promoting cell adhesion, migration and invasion through glycosylation of integrin beta1 and LAMP-2., [RefSeq, PubMed]; N-glycosylation by N-acetylglucosaminyltransferase IVa enhances the interaction of integrin beta1 with vimentin and promotes hepatocellular carcinoma cell motility., [RefSeq, PubMed]; This gene encodes a key glycosyltransferase that regulates the formation of tri- and multiantennary branching structures in the Golgi apparatus. The encoded protein, in addition to the related isoenzyme B, catalyzes the transfer of N-acetylglucosamine (GlcNAc) from UDP-GlcNAc in a beta-1,4 linkage to the Man-alpha-1,3-Man-beta-1,4-GlcNAc arm of R-Man-alpha-1,6(GlcNAc-beta-1,2-Man-alpha-1,3)Man-beta-1, 4-GlcNAc-beta-1,4-GlcNAc-beta-1-Asn. The encoded protein may play a role in regulating the availability of serum glycoproteins, oncogenesis, and differentiation. [provided by RefSeq, Jul 2008]., [RefSeq]; Upregulation of mannosyl (alpha-1,3-)-glycoprotein beta-1,4-N-acetyl-glucosaminyl-transferase is associated with metastatic colorectal carcinoma, [RefSeq, PubMed]; We investigated mRNA levels of glycosyltransferases, namely, N-acetylglucosaminyltransferase a (GnT)-IVa, and found that (GnT)-IVa expression was decreased in HLE-cells Epirubicin resistant. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 523,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E2R6;D3DVH6;E9PEN2;Q53S97;Q86Z15",
        "ec_number_list": [
            {
                "id": "1.8.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2",
                "type": "external"
            },
            {
                "id": "3.4.24.81",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81",
                "type": "external"
            },
            {
                "id": "3.4.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.-",
                "type": "external"
            },
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "1.16.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.1",
                "type": "external"
            },
            {
                "id": "1.11.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.9",
                "type": "external"
            },
            {
                "id": "1.16.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.16.3.4",
                "type": "external"
            },
            {
                "id": "3.4.21.69",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69",
                "type": "external"
            },
            {
                "id": "5.3.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.4.1.155",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.155",
                "type": "external"
            },
            {
                "id": "3.4.21.112",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.112",
                "type": "external"
            },
            {
                "id": "3.1.1.98",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.98",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "3.2.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.51",
                "type": "external"
            },
            {
                "id": "2.4.1.68",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.68",
                "type": "external"
            },
            {
                "id": "2.4.1.145",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.145",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046872 metal ion binding;GO:0008375 acetylglucosaminyltransferase activity;GO:0008453 alanine-glyoxylate transaminase activity;GO:0008454 alpha-1,3-mannosylglycoprotein 4-beta-N-acetylglucosaminyltransferase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005777 peroxisome;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0019082 viral protein processing;GO:0009101 glycoprotein biosynthetic process;GO:0046487 glyoxylate metabolic process;GO:0006487 protein N-linked glycosylation;GO:0006491 N-glycan processing",
        "synthesized_glycan_count": 3884,
        "hit_score": 13.2,
        "record_id": "Q9UM21-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000010001.101.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7L4E1-1",
        "uniprot_id": [
            {
                "id": "MIGA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7L4E1",
                "type": "external"
            }
        ],
        "mass": 65531.0,
        "length": 593,
        "protein_name": "Mitoguardin 2",
        "gene_name": "MIGA2",
        "organism": "Human",
        "refseq_name": "mitoguardin 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001316919",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316919",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MIGA2; C9orf54; FAM73B; PSEC0112",
        "gene_names_refseq": "C9orf54; FAM73B; MIGA2",
        "protein_names_uniprotkb": "Mitoguardin 2; Protein FAM73B",
        "protein_names_refseq": "family with sequence similarity 73, member B; mitoguardin 2 isoform 2; protein FAM73B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84895);  (R-HSA-1483166)",
        "pathway_count": 2,
        "publication_count": 71,
        "publication_id_list": "10455175;10506173;10553003;10681567;11031251;11112443;11237011;11788596;11830583;12063250;12161451;12359733;12522102;12963729;14573790;15367102;16303743;16460752;16495223;16620771;16704971;16864775;17028579;17170135;17707131;18238778;18669648;18718904;19336658;19666841;19690332;20705608;21173190;22777291;22922100;23176821;23176823;23186163;23481700;23807634;24966474;25880248;26711011;27600516;28832583;28904123;29242379;2925608;29393594;29557506;30429286;31848261;32157095;32357974;33124732;33968037;3458202;35051231;36241641;38843396;7060561;7821823;8163052;8186247;8300559;8530346;8687421;9188469;9212163;9461603;9582313",
        "class_list": "",
        "function": "Propose that MIGA1/2 proteins promote mitochondrial fusion by regulating mitochondrial phospholipid metabolism via MitoPLD., [RefSeq, PubMed]; Regulator of mitochondrial fusion: acts by forming homo- and heterodimers at the mitochondrial outer membrane and facilitating the formation of PLD6/MitoPLD dimers. May act by regulating phospholipid metabolism via PLD6/MitoPLD., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8NBM3;Q8TEJ6;Q969E6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0008053 mitochondrial fusion",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "Q7L4E1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BV79-1",
        "uniprot_id": [
            {
                "id": "MECR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BV79",
                "type": "external"
            }
        ],
        "mass": 40462.0,
        "length": 373,
        "protein_name": "Enoyl-[acyl-carrier-protein] reductase, mitochondrial",
        "gene_name": "MECR",
        "organism": "Human",
        "refseq_name": "enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform b",
        "refseq_ac": [
            {
                "id": "NP_001019903",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001019903",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MECR; CGI-63; NBRF1",
        "gene_names_refseq": "CGI-63; DYTOABG; ETR1; FASN2B; MECR; NRBF1; OPA16",
        "protein_names_uniprotkb": "Enoyl-[acyl-carrier-protein] reductase, mitochondrial; 1.3.1.104; 2-enoyl thioester reductase; HsNrbf-1; NRBF-1; Nuclear receptor-binding factor 1",
        "protein_names_refseq": "enoyl-[acyl-carrier-protein] reductase, mitochondrial isoform b; enoyl-[acyl-carrier-protein] reductase, mitochondrial; homolog of yeast 2-enoyl thioester reductase; mitochondrial 2-enoyl thioester reductase; nuclear receptor binding factor 1; trans-2-enoyl-CoA reductase, mitochondrial",
        "tax_id": 9606,
        "disease": "childhood-onset dystonia with optic atrophy and basal ganglia abnormalities (Disease Ontology:DOID:0081419); Leber hereditary optic neuropathy with demyelinating disease of CNS (Disease Ontology:DOID:0111756); optic atrophy (Disease Ontology:DOID:5723); optic atrophy 16 (MONDO:MONDO:0957978)",
        "pathway": " (hsa:51102);  (R-HSA-77346)",
        "pathway_count": 2,
        "publication_count": 19,
        "publication_id_list": "11237011;12654921;13295225;13295248;1550553;18479707;20877624;22645359;25031892;26992070;27817865;29557506;30315122;34357683;3597357;36542656;37653044;37734847;8687463",
        "class_list": "",
        "function": "Alternative splicing liberates a cryptic cytoplasmic isoform of mitochondrial MECR that antagonizes influenza virus. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Displays a preference for medium-chain over short- and long-chain substrates (PubMed:12654921, PubMed:18479707, PubMed:27817865). May provide the octanoyl chain used for lipoic acid biosynthesis, regulating protein lipoylation and mitochondrial respiratory activity particularly in Purkinje cells (By similarity). Involved in iron homeostasis; affecting Fe-S cluster assembly and ceramide metabolism (PubMed:37653044). Required for proper morphology and bioenergetic functions of mitochondria (PubMed:37653044). Required for maintenance of neurons (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Recessive MECR pathogenic variants cause an LHON-like optic neuropathy. Publication Status: Online-Only, [RefSeq, PubMed]; The crystal structure of this dimeric enzyme (at 2.4 A resolution) suggests that the binding site for the recognition helix of the acyl carrier protein is in a groove between the two adjacent monomers., [RefSeq, PubMed]; The protein encoded by this gene is an oxidoreductase that catalyzes the last step in mitochondrial fatty acid synthesis. Defects in this gene are a cause of childhood-onset dystonia and optic atrophy. [provided by RefSeq, Mar 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KT72;Q5SYU0;Q5SYU1;Q5SYU2;Q6IBU9;Q9Y373",
        "ec_number_list": [
            {
                "id": "1.1.1.100",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.100",
                "type": "external"
            },
            {
                "id": "1.3.1.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.39",
                "type": "external"
            },
            {
                "id": "2.3.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.38",
                "type": "external"
            },
            {
                "id": "2.3.1.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.39",
                "type": "external"
            },
            {
                "id": "2.3.1.41",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.41",
                "type": "external"
            },
            {
                "id": "2.3.1.85",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.85",
                "type": "external"
            },
            {
                "id": "3.1.2.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.2.14",
                "type": "external"
            },
            {
                "id": "4.2.1.59",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.59",
                "type": "external"
            },
            {
                "id": "1.3.1.104",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.104",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0141148 enoyl-[acyl-carrier-protein] reductase (NADPH) activity;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0016020 membrane",
        "go_biological_process": "GO:0006631 fatty acid metabolic process;GO:0046513 ceramide biosynthetic process;GO:0006633 fatty acid biosynthetic process;GO:0006879 intracellular iron ion homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q9BV79-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P33032-1",
        "uniprot_id": [
            {
                "id": "MC5R_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P33032",
                "type": "external"
            }
        ],
        "mass": 36601.0,
        "length": 325,
        "protein_name": "Melanocortin receptor 5",
        "gene_name": "MC5R",
        "organism": "Human",
        "refseq_name": "melanocortin receptor 5",
        "refseq_ac": [
            {
                "id": "NP_005904",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005904",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MC5R",
        "gene_names_refseq": "MC2; MC5R",
        "protein_names_uniprotkb": "Melanocortin receptor 5; MC-2; MC5-R",
        "protein_names_refseq": "melanocortin receptor 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4161);  (R-HSA-375276);  (R-HSA-418555);  (R-HSA-9856649)",
        "pathway_count": 4,
        "publication_count": 206,
        "publication_id_list": "10079109;10100623;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567402;10604470;10611221;10655586;10673502;10854085;10899166;11007482;11027551;11286624;11322507;11385580;11457843;11562423;11683476;11773063;11840323;11891324;11912130;11930005;12036966;12058044;12106601;12180353;12427552;12540846;12719537;1280419;12860470;12956774;1314587;1317848;1325670;1337145;1346068;13549488;14463577;14550283;14573733;14671004;14975237;15118077;15139756;1517224;15226305;15507434;15539556;1567413;15765929;15769620;15947423;15951850;16014379;16034366;16313925;1655761;16687412;16822840;16923326;1698554;1710450;1710578;17168849;1719979;1722333;1748288;17623675;18044684;18127230;1847994;18577758;18644867;19105585;19428994;19524539;19608861;19876791;19929708;20381629;20460180;21036126;21486943;2163110;21965087;22647378;23159739;23190890;23207919;23446738;23481700;23690594;2417744;24687066;24906252;2491850;25248477;2553411;2553705;25595898;26417854;2649896;27128622;27496565;28394346;28396017;2871555;29295999;29443750;29557506;29602314;30739530;30804224;30833945;30833991;3127824;31279028;31399091;31983287;3202875;32226383;32497535;32540603;32618402;32636443;32715661;33049737;3366244;33744299;33765750;34140478;3525564;35580925;37524700;37770430;3856870;5338216;6085243;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7739752;7797512;7905839;7958932;8035319;8062389;8063797;8179577;8185599;8201839;8248172;8294032;8336698;8340388;8373420;8381365;8383682;8395824;8396929;8440682;8463333;8503909;8514797;8615752;8666380;8672451;8702752;873923;8823230;9171878;9199364;9240466;9263355;9353119;9417641;9440696;9521323;9530155;9560246;9593744;9607765;9651336;9676189;9685625;9722565;9760192;9792798;9832121;9851594;9973413",
        "class_list": "",
        "function": "Evaluation of perilipin 2 and melanocortin 5 receptor serum levels with sebogenesis in acne vulgaris patients., [RefSeq, PubMed]; G protein-coupled receptor for melanocyte-stimulating hormones (alpha- beta- and gamma-MSH) and corticotropin/ACTH, which are peptide products of the POMC precursor (PubMed:37524700, PubMed:8396929). Upon activation, couples to G(s) protein, stimulating adenylate cyclase and the cAMP-dependent signaling pathway (PubMed:37524700). Also activates ERK1/2 via a PI3K-dependent signaling mechanism (PubMed:19428994). Order of potency of natural melanocortins in receptor activation is alpha-MSH > ACTH > beta-MSH > gamma-MSH (PubMed:8396929). Plays a key role in immune response, and is essential for temperature regulation and exocrine gland function (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; MCR5 is a modulator of the responses stimulated by glucose in ARPE-19 cells, which might possibly be translated into a modulation of the retinal pigment epithelium response to diabetes in vivo., [RefSeq, PubMed]; Mutations in residues S4/S5 and S17/E18 retained MC5R at the ER/Golgi complex and did not affect MC5R homodimerization., [RefSeq, PubMed]; This gene encodes a member of the seven-pass transmembrane G protein-coupled melanocortin receptor protein family that stimulate cAMP signal transduction. The encoded protein is a receptor for melanocyte-stimulating hormone and adrenocorticotropic hormone and is suggested to play a role in sebum generation. [provided by RefSeq, Jun 2010]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 19,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0YJ34;Q502V1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0042562 hormone binding;GO:0004977 melanocortin receptor activity;GO:0004978 corticotropin receptor activity;GO:0004980 melanocyte-stimulating hormone receptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0001659 temperature homeostasis;GO:0007165 signal transduction;GO:0007189 adenylate cyclase-activating G protein-coupled receptor signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger",
        "synthesized_glycan_count": 0,
        "hit_score": 20.7,
        "record_id": "P33032-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q68CQ1-7",
        "uniprot_id": [
            {
                "id": "MROH7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q68CQ1",
                "type": "external"
            }
        ],
        "mass": 145647.0,
        "length": 1323,
        "protein_name": "Maestro heat-like repeat-containing protein family member 7",
        "gene_name": "MROH7",
        "organism": "Human",
        "refseq_name": "maestro heat-like repeat-containing protein family member 7 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001034553",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034553",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MROH7; C1orf175; HEATR8",
        "gene_names_refseq": "C1orf175; HEATR8; MROH7",
        "protein_names_uniprotkb": "Maestro heat-like repeat-containing protein family member 7; HEAT repeat-containing protein 8",
        "protein_names_refseq": "HEAT repeat-containing protein 8; maestro heat-like repeat-containing protein family member 7 isoform 1; maestro heat-like repeat-containing protein family member 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:374977)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "10.1101/2023.09.13.557529;16959974;18452278;18491316;25645385;29493099;29557506;30524438;32350084;32387766;32488085;37217939",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 49,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AUX8;Q5TA99;Q6ZP40;Q6ZRH6;Q8N311;Q8NA14",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm;GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q68CQ1-7",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96IW2-1",
        "uniprot_id": [
            {
                "id": "SHD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96IW2",
                "type": "external"
            }
        ],
        "mass": 38264.0,
        "length": 340,
        "protein_name": "SH2 domain-containing adapter protein D",
        "gene_name": "SHD",
        "organism": "Human",
        "refseq_name": "SH2 domain-containing adapter protein D",
        "refseq_ac": [
            {
                "id": "NP_064594",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064594",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SHD",
        "gene_names_refseq": "SHD",
        "protein_names_uniprotkb": "SH2 domain-containing adapter protein D",
        "protein_names_refseq": "SH2 domain-containing adapter protein D; src homology 2 domain-containing transforming protein D",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56961)",
        "pathway_count": 1,
        "publication_count": 5,
        "publication_id_list": "11237011;32938616;34087483;35051231;35580925",
        "class_list": "",
        "function": "May function as an adapter protein., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96NC2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001784 phosphotyrosine residue binding",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q96IW2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6NSI4-1",
        "uniprot_id": [
            {
                "id": "RADX_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6NSI4",
                "type": "external"
            }
        ],
        "mass": 97554.0,
        "length": 855,
        "protein_name": "RPA-related protein RADX",
        "gene_name": "RADX",
        "organism": "Human",
        "refseq_name": "RPA-related protein RADX isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001171711",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171711",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RADX; CXorf57",
        "gene_names_refseq": "CXorf57; RADX",
        "protein_names_uniprotkb": "RPA-related protein RADX; RPA-related and RAD51-antagonist, X-chromosome",
        "protein_names_refseq": "RPA-related and RAD51-antagonist, X-chromosome; RPA-related protein RADX isoform 2; RPA-related protein RADX; RPA-related, RAD51-antagonist on X-chromosome; uncharacterized protein CXorf57",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55086)",
        "pathway_count": 1,
        "publication_count": 48,
        "publication_id_list": "11237011;23481700;24714562;25576301;25645385;25880248;26375851;26728094;26992070;27846572;27920218;28063628;28228285;28735897;28832583;28834231;28904123;29242379;29493099;29557506;29632046;30021152;30315122;30379171;30410026;30779550;31154438;31844290;32157095;32357974;32387766;32488085;32938616;33141586;33298915;33453169;33592498;33633747;33691108;33717175;33968037;34087483;34171305;34509645;35051231;35120927;36010968;36241641",
        "class_list": "",
        "function": "Oligomerization of DNA replication regulatory protein RADX is essential to maintain replication fork stability., [RefSeq, PubMed]; RADX buffers RAD51 to ensure the right amount of reversal and protection to maintain genome stability., [RefSeq, PubMed]; RADX controls RAD51 filament dynamics to regulate replication fork stability., [RefSeq, PubMed]; Single-stranded DNA-binding protein recruited to replication forks to maintain genome stability (PubMed:28735897). Prevents fork collapse by antagonizing the accumulation of RAD51 at forks to ensure the proper balance of fork remodeling and protection without interfering with the capacity of cells to complete homologous recombination of double-strand breaks (PubMed:28735897)., [UniProtKB, PubMed]",
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        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "H7BY89;Q4G0L7;Q5JQS1;Q5JRF9;Q6PHY5;Q6PII9;Q6PJU8;Q9H7W5;Q9NWA6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003697 single-stranded DNA binding",
        "go_cellular_component": "GO:0016607 nuclear speck;GO:0005657 replication fork",
        "go_biological_process": "GO:2000042 negative regulation of double-strand break repair via homologous recombination;GO:0006282 regulation of DNA repair",
        "synthesized_glycan_count": 0,
        "hit_score": 5.3,
        "record_id": "Q6NSI4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UBB5-1",
        "uniprot_id": [
            {
                "id": "MBD2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UBB5",
                "type": "external"
            }
        ],
        "mass": 43255.0,
        "length": 411,
        "protein_name": "Methyl-CpG-binding domain protein 2",
        "gene_name": "MBD2",
        "organism": "Human",
        "refseq_name": "methyl-CpG-binding domain protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_003918",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003918",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MBD2",
        "gene_names_refseq": "DMTase; MBD2; NY-CO-41",
        "protein_names_uniprotkb": "Methyl-CpG-binding domain protein 2; DMTase; Demethylase; Methyl-CpG-binding protein MBD2",
        "protein_names_refseq": "demethylase; methyl-CpG-binding domain protein 2 isoform 1",
        "tax_id": 9606,
        "disease": "transient cerebral ischemia (Disease Ontology:DOID:224); schizophrenia (Disease Ontology:DOID:5419); rheumatoid arthritis (Disease Ontology:DOID:7148); choline deficiency disease (Disease Ontology:DOID:8456); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:8932);  (R-HSA-427413);  (R-HSA-73728);  (R-HSA-9937850);  (R-HSA-9940951)",
        "pathway_count": 5,
        "publication_count": 109,
        "publication_id_list": "10050851;10204490;10441743;10471499;10947852;10950960;10970879;10978333;11102443;11237011;11553631;11741541;12183469;12504854;12588985;12665568;14610093;15456747;15516265;15643425;15701600;16415179;16428440;16707490;17081983;17355984;17646674;18452278;18571423;18669648;19413330;19415658;19651622;19690332;19729656;19838300;20068231;20523938;21490301;22398447;23186163;23239876;2330041;23361464;24252660;24275569;24307175;24385926;24554700;24714562;24715725;24920672;25150861;25593309;25753662;25916849;26992070;27397612;27633282;27732854;27806305;27862975;28533432;28832583;28977666;29042441;29493099;29557506;29786170;30045876;30122475;30134174;30228260;30327463;30410026;30429286;30980593;31746185;31844290;31848261;32157095;32357974;32502341;32938616;32983136;33264408;33283408;33592498;33633747;33717175;33936100;34171305;34433824;35051231;35734966;36008597;36010968;36037972;36090987;36581221;36961677;37938771;7597036;7969165;9427644;9512513;9774669;9804427;9885572",
        "class_list": "",
        "function": "Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides (PubMed:9774669). Binds hemimethylated DNA as well (PubMed:10947852, PubMed:24307175). Recruits histone deacetylases and DNA methyltransferases to chromatin (PubMed:10471499, PubMed:10947852). Acts as a component of the histone deacetylase NuRD complex which participates in the remodeling of chromatin (PubMed:16428440, PubMed:28977666). Acts as a transcriptional repressor and plays a role in gene silencing (PubMed:10471499, PubMed:10947852, PubMed:16415179). Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression (PubMed:16415179). May enhance the activation of some unmethylated cAMP-responsive promoters (PubMed:12665568)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Blockade of Mbd2 by siRNA-loaded liposomes protects mice against OVA-induced allergic airway inflammation via repressing M2 macrophage production. Publication Status: Online-Only, [RefSeq, PubMed]; DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. The protein encoded by this gene may function as a mediator of the biological consequences of the methylation signal. It is also reported that the this protein functions as a demethylase to activate transcription, as DNA methylation causes gene silencing. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2011]., [RefSeq]; Densely methylated DNA traps Methyl-CpG-binding domain protein 2 but permits free diffusion by Methyl-CpG-binding domain protein 3., [RefSeq, PubMed]; Hsa-miR-221-3p promotes proliferation and migration in HER2-positive breast cancer cells by targeting LASS2 and MBD2., [RefSeq, PubMed]; MiR-146a-3p as a potential novel therapeutic by targeting MBD2 to mediate Th17 differentiation in Th17 predominant neutrophilic severe asthma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 5,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O95242;Q9UIS8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding;GO:0003729 mRNA binding;GO:0019904 protein domain specific binding;GO:0008327 methyl-CpG binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0031667 response to nutrient levels;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 11.0,
        "record_id": "Q9UBB5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N344-1",
        "uniprot_id": [
            {
                "id": "MIER2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N344",
                "type": "external"
            }
        ],
        "mass": 59944.0,
        "length": 545,
        "protein_name": "Mesoderm induction early response protein 2",
        "gene_name": "MIER2",
        "organism": "Human",
        "refseq_name": "mesoderm induction early response protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_060020",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060020",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MIER2; KIAA1193",
        "gene_names_refseq": "KIAA1193; MIER2; Mi-er2",
        "protein_names_uniprotkb": "Mesoderm induction early response protein 2; Mi-er2",
        "protein_names_refseq": "mesoderm induction early response 1, family member 2; mesoderm induction early response protein 2 isoform 1; mesoderm induction early response protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54531)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "11237011;19061646;20068231;23186163;27400125;28046085;29557506;31844290;32357974;32502341;32938616;33298915;33592498;33912179;33968037;34087483;35051231;35561310;35580925;36010968",
        "class_list": "",
        "function": "Histone deacetylase assays confirmed that MIER2, but not MIER3 complexes, have associated deacetylase activity. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor., [UniProtKB]",
        "predicted_glycosites": 0,
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        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9ULM7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q8N344-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "MGDP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86V88",
                "type": "external"
            }
        ],
        "mass": 20109.0,
        "length": 176,
        "protein_name": "Magnesium-dependent phosphatase 1",
        "gene_name": "MDP1",
        "organism": "Human",
        "refseq_name": "magnesium-dependent phosphatase 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001186750",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186750",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MDP1",
        "gene_names_refseq": "FN6PASE; MDP-1; MDP1",
        "protein_names_uniprotkb": "Magnesium-dependent phosphatase 1; 3.1.3.-; 3.1.3.48; MDP-1",
        "protein_names_refseq": "fructosamine-6-phosphatase; magnesium-dependent phosphatase 1 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:145553)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "22706990;25502872;25576301;26992070;28228285;28678323;28832583;29242379;29557506;29786170;31218958;31844290;32157095;32350084;32488085;32502341;32938616;32983136;33592498;33968037;34561969;35051231;36010968;36241641",
        "class_list": "",
        "function": "Magnesium-dependent Phosphatase (MDP) 1 is a Potential Suppressor of Gastric Cancer., [RefSeq, PubMed]; Magnesium-dependent phosphatase which may act as a tyrosine phosphatase., [UniProtKB]; We showed that down-regulation of MDP-1 expression was correlated with poorly differentiated carcinoma and later tumor stage, and it predicted a significantly poorer disease-free survival., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86Y84;Q8NAD9",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21",
                "type": "external"
            },
            {
                "id": "3.1.3.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0003993 acid phosphatase activity;GO:0004725 protein tyrosine phosphatase activity",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
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        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
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            {
                "id": "MDS2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NDY4",
                "type": "external"
            }
        ],
        "mass": 15384.0,
        "length": 140,
        "protein_name": "Myelodysplastic syndrome 2 translocation-associated protein",
        "gene_name": "MDS2",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "MDS2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Myelodysplastic syndrome 2 translocation-associated protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
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        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "12203785;28832583",
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        "go_cellular_component": "GO:0005615 extracellular space",
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        "record_id": "Q8NDY4-1",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96KG7-1",
        "uniprot_id": [
            {
                "id": "MEG10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96KG7",
                "type": "external"
            }
        ],
        "mass": 122205.0,
        "length": 1140,
        "protein_name": "Multiple epidermal growth factor-like domains protein 10",
        "gene_name": "MEGF10",
        "organism": "Human",
        "refseq_name": "multiple epidermal growth factor-like domains protein 10 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001243474",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243474",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MEGF10; KIAA1780",
        "gene_names_refseq": "CMYO10A; CMYO10B; CMYP10A; CMYP10B; EMARDD; MEGF10; SR-F3",
        "protein_names_uniprotkb": "Multiple epidermal growth factor-like domains protein 10; Multiple EGF-like domains protein 10",
        "protein_names_refseq": "multiple epidermal growth factor-like domains protein 10 isoform a precursor; multiple epidermal growth factor-like domains protein 10",
        "tax_id": 9606,
        "disease": "congenital myopathy 10B (Disease Ontology:DOID:0081345); congenital myopathy 10A (Disease Ontology:DOID:0111333); neurodegenerative disease (Disease Ontology:DOID:1289); myopathy (Disease Ontology:DOID:423)",
        "pathway": " (hsa:84466)",
        "pathway_count": 1,
        "publication_count": 26,
        "publication_id_list": "17205124;17498693;17643423;18179784;18767875;20828568;22101682;22371254;23090970;23954233;24190977;27170117;27460346;28498977;29128256;29242379;29557506;31154438;31844290;32488085;33512044;33592498;34828389;36349186;36849355;37938771",
        "class_list": "",
        "function": "An interaction between MEGF10 and clathrin assembly protein complex 2 medium chain (AP50), a component of clathrin-coated pits was identified., [RefSeq, PubMed]; Human MEGF10 is an ortholog of Ced1., [RefSeq, PubMed]; In a system of forced expression by transfection, MEGF10 function can be modulated by the ATP binding cassette transporter ABCA1, ortholog to CED-7 Publication Status: Online-Only, [RefSeq, PubMed]; In expression studies, MEGF10 had higher expression levels in the affected than the unaffected (p = .015). Schizophrenia patients with a 1/1 genotype at rs27388 had higher expressions than those patients with 1/2 and 2/2 genotypes (p = .0008). GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; MEGF10 is involved in the uptake of amyloid-beta peptide (Abeta42) in the brain., [RefSeq, PubMed]; Membrane receptor involved in phagocytosis by macrophages and astrocytes of apoptotic cells. Receptor for C1q, an eat-me signal, that binds phosphatidylserine expressed on the surface of apoptotic cells (PubMed:27170117). Cooperates with ABCA1 within the process of engulfment. Promotes the formation of large intracellular vacuoles and may be responsible for the uptake of amyloid-beta peptides (PubMed:17643423, PubMed:20828568). Necessary for astrocyte-dependent apoptotic neuron clearance in the developing cerebellum (PubMed:27170117). Plays role in muscle cell proliferation, adhesion and motility. Is also an essential factor in the regulation of myogenesis. Controls the balance between skeletal muscle satellite cells proliferation and differentiation through regulation of the notch signaling pathway (PubMed:28498977, Ref.16). May also function in the mosaic spacing of specific neuron subtypes in the retina through homotypic retinal neuron repulsion. Mosaics provide a mechanism to distribute each cell type evenly across the retina, ensuring that all parts of the visual field have access to a full set of processing elements (PubMed:17498693, PubMed:17643423, PubMed:20828568, PubMed:22101682, PubMed:27170117, PubMed:28498977)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Mutations in MEGF10, a regulator of satellite cell myogenesis, cause early onset myopathy, areflexia, respiratory distress and dysphagia (EMARDD) Publication Status: Online-Only, [RefSeq, PubMed]; Phenotypic Variability of MEGF10 Variants Causing Congenital Myopathy: Report of Two Unrelated Patients from a Highly Consanguineous Population. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the multiple epidermal growth factor-like domains protein family. The encoded protein plays a role in cell adhesion, motility and proliferation, and is a critical mediator of apoptotic cell phagocytosis as well as amyloid-beta peptide uptake in the brain. Expression of this gene may be associated with schizophrenia, and mutations in this gene are a cause of early-onset myopathy, areflexia, respiratory distress, and dysphagia (EMARDD) as well as congenital myopathy with minicores. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Apr 2012]., [RefSeq]; ZNF667-AS1, a positively regulating MEGF10, inhibits the progression of uveal melanoma by modulating cellular aggressiveness., [RefSeq, PubMed]; [A family with early onset myopathy caused by MEGF10 gene defect and literature review]. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
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        "total_reported_n_glycosites": 3,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q68DE5;Q8WUL3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005044 scavenger receptor activity;GO:0005112 Notch binding;GO:0001849 complement component C1q complex binding",
        "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0022409 positive regulation of cell-cell adhesion;GO:0014816 skeletal muscle satellite cell differentiation;GO:0034109 homotypic cell-cell adhesion;GO:0043652 engulfment of apoptotic cell;GO:0051451 myoblast migration",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q96KG7-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BUN1-1",
        "uniprot_id": [
            {
                "id": "MENT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BUN1",
                "type": "external"
            }
        ],
        "mass": 36769.0,
        "length": 341,
        "protein_name": "Protein MENT",
        "gene_name": "MENT",
        "organism": "Human",
        "refseq_name": "protein MENT precursor",
        "refseq_ac": [
            {
                "id": "NP_060330",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060330",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MENT; C1orf56; PRO1104",
        "gene_names_refseq": "C1orf56; MENT",
        "protein_names_uniprotkb": "Protein MENT; Methylated in normal thymocytes protein",
        "protein_names_refseq": "methylated in normal thymocytes protein; protein MENT precursor; protein MENT",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54964)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "10.1021/acs.analchem.6b02887;10.1038/emboj.2013.79;12975309;19824718;22133874;23584533;24094886;24715725;25892735;27846572;28035807;29393594;30459171;32157095;32161166;32350084;33298915;35051231;35251023;41018975",
        "class_list": "",
        "function": "DNMT3B7 overexpression might interfere with the normal DNA methylation mechanism required for silencing the MENT proto-oncogene, and may accelerate human lymphomagenesis., [RefSeq, PubMed]; Involved in control of cellular proliferation. Onconcogenic modifier contributing to the tumor suppressor function of DNMT3B., [UniProtKB, PubMed]; This gene is a proto-oncogene whose promoter is methylated by DNA methyltransferase 3B (DNMT3B), which represses the proto-oncogene. However, a catalytically inactive isoform of DNMT3B is overexpressed in lymphomas, leading to hypomethylation of the proto-oncogene's promoter and derepression of the proto-oncogene. [provided by RefSeq, Sep 2016]., [RefSeq]",
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        "secondary_ac_list": "B2RDU8;Q9NWZ4",
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        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0042127 regulation of cell population proliferation",
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    {
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            {
                "id": "MI1HG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H1L0",
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        ],
        "mass": 12410.0,
        "length": 117,
        "protein_name": "Uncharacterized protein MIR1-1HG",
        "gene_name": "MIR1-1HG",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "MIR1-1HG; C20orf166",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Uncharacterized protein MIR1-1HG; MIR1-1 host gene protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
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        "secondary_ac_list": "Q2TB30",
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        "record_id": "Q9H1L0-1",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IYU8-1",
        "uniprot_id": [
            {
                "id": "MICU2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IYU8",
                "type": "external"
            }
        ],
        "mass": 49666.0,
        "length": 434,
        "protein_name": "Calcium uptake protein 2, mitochondrial",
        "gene_name": "MICU2",
        "organism": "Human",
        "refseq_name": "calcium uptake protein 2, mitochondrial",
        "refseq_ac": [
            {
                "id": "NP_689939",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_689939",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MICU2; EFHA1",
        "gene_names_refseq": "1110008L20Rik; EFHA1; MICU2; hMICU3",
        "protein_names_uniprotkb": "Calcium uptake protein 2, mitochondrial; EF-hand domain-containing family member A1; hMICU3",
        "protein_names_refseq": "EF hand domain family A1; EF hand domain family, member A1; EF-hand domain-containing family member A1; Smhs2 homolog; calcium uptake protein 2, mitochondrial",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:221154);  (R-HSA-8949215);  (R-HSA-8949664);  (R-HSA-9837999)",
        "pathway_count": 4,
        "publication_count": 127,
        "publication_id_list": "11237011;11923310;12198491;12438411;14623864;15522782;15870080;15904662;16115876;17101804;17178908;17297443;17579211;18628306;18669648;18991276;19797662;19841671;20018762;20693986;20877624;21685886;21685888;21720385;22262461;22710082;23201127;23409044;23481700;23716663;23755363;23900286;23931759;24162235;24231807;24315374;24344246;24503055;24520911;24560927;24715725;24898248;25077561;25171321;25565209;25576301;25753332;26154972;26341627;26387864;26504172;26774479;26903221;26923599;26976564;26992070;27099988;27397612;27496948;27642048;27669901;27737933;27846572;27920218;28218747;28377575;28396416;28510447;28615291;28832583;28904123;29242379;29301859;29437277;29493099;29557506;29932645;30120231;30429286;30699349;31327635;31397067;31695197;31844290;32148862;32157095;32357974;32387766;32488085;32494073;32502341;32667285;32762847;32790952;32862359;32897882;32938616;32983136;33123756;33141586;33257573;33296646;33298915;33392160;33592498;33691108;33717175;33912179;33932586;33936100;33968037;34171305;34211107;34561969;34704252;34932366;34943861;35051231;35561310;35580925;35870450;36241641;36284347;36629048;37217939;7399049;7623837",
        "class_list": "",
        "function": "Calcium sensor of the mitochondrial calcium uniporter (MCU) channel, which senses calcium level via its EF-hand domains (PubMed:24503055, PubMed:24560927, PubMed:26903221, PubMed:28615291, PubMed:30699349, PubMed:31397067, PubMed:32494073, PubMed:32667285, PubMed:32762847, PubMed:32790952). MICU1 and MICU2 form a disulfide-linked heterodimer that stimulates and inhibits MCU activity, depending on the concentration of calcium (PubMed:24560927, PubMed:26903221, PubMed:28615291, PubMed:30699349, PubMed:31397067, PubMed:32148862, PubMed:32494073, PubMed:32667285, PubMed:32762847, PubMed:32790952). At low calcium levels, MICU1 occludes the pore of the MCU channel, preventing mitochondrial calcium uptake (PubMed:32494073, PubMed:32667285, PubMed:32762847). At higher calcium levels, calcium-binding to MICU1 and MICU2 induces a conformational change that weakens MCU-MICU1 interactions and moves the MICU1-MICU2 heterodimer away from the pore, allowing calcium permeation through the MCU channel (PubMed:32494073, PubMed:32667285, PubMed:32762847)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex., [RefSeq, PubMed]; Mitochondrial clearance of calcium facilitated by MICU2 controls insulin secretion., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
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        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
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        "reported_mutagensis": 13,
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        "reported_snv": 10,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N0T6;Q8NAX8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046982 protein heterodimerization activity;GO:0005246 calcium channel regulator activity;GO:0005509 calcium ion binding;GO:0061891 calcium ion sensor activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005758 mitochondrial intermembrane space;GO:0034704 calcium channel complex;GO:1990246 uniplex complex",
        "go_biological_process": "GO:0051562 negative regulation of mitochondrial calcium ion concentration;GO:0071277 cellular response to calcium ion;GO:0006851 mitochondrial calcium ion transmembrane transport;GO:0036444 calcium import into the mitochondrion;GO:0051560 mitochondrial calcium ion homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 13.0,
        "record_id": "Q8IYU8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
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                "url": "https://www.uniprot.org/uniprot/Q99705",
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        ],
        "mass": 38940.0,
        "length": 353,
        "protein_name": "Melanin-concentrating hormone receptor 1",
        "gene_name": "MCHR1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "MCHR1; GPR24; SLC1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Melanin-concentrating hormone receptor 1; G protein-coupled receptor 24; MCH receptor 1; MCH-1R; MCH-R1; MCH1R; MCHR-1; MCHR; SLC-1; Somatostatin receptor-like protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "morbid obesity (Disease Ontology:DOID:11981); Parkinson's disease (Disease Ontology:DOID:14330); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:2847);  (R-HSA-375276);  (R-HSA-416476);  (R-HSA-418594);  (R-HSA-5620922)",
        "pathway_count": 5,
        "publication_count": 155,
        "publication_id_list": "10079109;10100623;10191087;10381885;10421367;10421368;10438732;10441476;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10899166;11007482;11015615;11237011;11252952;11322507;11385580;11457843;11562423;11683476;11742120;11753430;11773063;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15166293;15258860;15314642;15340116;15539556;1567413;15941924;15947423;15951850;16182515;16268778;16339447;1655761;16634148;16754659;16923326;16945926;1710450;1710578;1719979;1722333;17574030;18127230;18434541;18477386;1847994;18515384;18577758;18936096;1905813;19081074;19320743;19421068;19575670;20080638;20233871;20603001;21427764;22072986;22139371;22389062;22500027;23351793;23446738;23481700;23690594;24296415;24906252;2534964;25443296;25446516;2649896;2748346;27496565;2834384;2841328;3086311;3202875;3366244;3525564;3856870;38710677;39616153;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8015379;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8406495;8440682;8463333;8503909;8615752;8664309;8666380;8702752;873923;8823230;8977118;9171878;9305846;9521323;9530155;9593744;9607765;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "G protein-coupled receptor for melanin-concentrating hormone (MCH) that signals primarily through G(i/o) to inhibit adenylyl cyclase, and can additionally couple to G(q/11) to stimulate phospholipase C and mobilize intracellular calcium (PubMed:10421367, PubMed:15340116, PubMed:38710677, PubMed:39616153). Predominantly localized within the central nervous system where it regulates various physiological processes including feeding behavior, energy homeostasis, stress/anxiety-related behaviors and sleep (PubMed:10421367, PubMed:15166293, PubMed:15941924)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
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        "secondary_ac_list": "B2RBX6;Q5R3J1;Q96S47;Q9BV08",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004930 G protein-coupled receptor activity;GO:0005102 signaling receptor binding;GO:0042562 hormone binding;GO:0008188 neuropeptide receptor activity;GO:0042923 neuropeptide binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005929 cilium;GO:0043005 neuron projection;GO:0097730 non-motile cilium;GO:0060170 ciliary membrane",
        "go_biological_process": "GO:0006091 generation of precursor metabolites and energy;GO:0007166 cell surface receptor signaling pathway;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007204 positive regulation of cytosolic calcium ion concentration",
        "synthesized_glycan_count": 0,
        "hit_score": 15.6,
        "record_id": "Q99705-1",
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    },
    {
        "uniprot_canonical_ac": "O15479-1",
        "uniprot_id": [
            {
                "id": "MAGB2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15479",
                "type": "external"
            }
        ],
        "mass": 35277.0,
        "length": 319,
        "protein_name": "Melanoma-associated antigen B2",
        "gene_name": "MAGEB2",
        "organism": "Human",
        "refseq_name": "melanoma-associated antigen B2",
        "refseq_ac": [
            {
                "id": "NP_002355",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002355",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAGEB2",
        "gene_names_refseq": "CT3.2; DAM6; MAGE-XP-2; MAGEB2",
        "protein_names_uniprotkb": "Melanoma-associated antigen B2; CT3.2; Cancer/testis antigen 3.2; DAM6; DSS-AHC critical interval MAGE superfamily 6; MAGE XP-2 antigen; MAGE-B2 antigen",
        "protein_names_refseq": "DSS/AHC critical interval MAGE superfamily 6; MAGE XP-2 antigen; MAGE-B2 antigen; cancer/testis antigen 3.2; cancer/testis antigen family 3, member 2; melanoma antigen family B, 2; melanoma antigen family B2; melanoma-associated antigen B2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4113)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "12018852;18669648;20864041;23186163;25576301;26992070;29930882;32002290;32157095;32387766;32488085;32582212;32897882;33141586;33392160;33592498;33741433;33968037;33981976;34171305;34509645;34725712;35051231;35618211;35874702;36010968;36211805;36215666;36241641;37938771;8535061;9441743;9538511",
        "class_list": "",
        "function": "Cancer germline antigen gene MAGEB2 promotes cell invasion and correlates with immune microenvironment and immunotherapeutic efficiency in laryngeal cancer., [RefSeq, PubMed]; Expression of the tumor-expressed protein MageB2 enhances rRNA transcription., [RefSeq, PubMed]; May enhance ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex., [UniProtKB, PubMed]; Results show that hypertonic culture medium differentially induces the expression of melanoma antigens B1 and B2 (MAGE-B1, -B2) in different human tumor cell lines., [RefSeq, PubMed]; This gene is a member of the MAGEB gene family. The members of this family have their entire coding sequences located in the last exon, and the encoded proteins show 50 to 68% sequence identity to each other. The promoters and first exons of the MAGEB genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. This gene is localized in the DSS (dosage-sensitive sex reversal) critical region. It is expressed in testis and placenta, and in a significant fraction of tumors of various histological types. The MAGEB genes are clustered on chromosome Xp22-p21. [provided by RefSeq, Jul 2008]., [RefSeq]",
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        "secondary_ac_list": "O75860",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II",
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    {
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            {
                "id": "MAGB3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15480",
                "type": "external"
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        ],
        "mass": 39211.0,
        "length": 346,
        "protein_name": "Melanoma-associated antigen B3",
        "gene_name": "MAGEB3",
        "organism": "Human",
        "refseq_name": "melanoma-associated antigen B3",
        "refseq_ac": [
            {
                "id": "NP_002356",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002356",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAGEB3",
        "gene_names_refseq": "CT3.5; MAGEB3",
        "protein_names_uniprotkb": "Melanoma-associated antigen B3; MAGE-B3 antigen",
        "protein_names_refseq": "MAGE-B3 antigen; cancer/testis antigen family 3, member 5; melanoma antigen family B, 3; melanoma antigen family B3; melanoma-associated antigen B3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4114)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "23481700;29242379;29632711;32938616;33141586;35051231;37217939;9441743",
        "class_list": "",
        "function": "This gene is a MAGE-B subfamily member of the MAGE gene family. MAGE family member proteins direct the expression of tumor antigens recognized on a human melanoma by autologous cytolytic T lymphocytes. There are two known clusters of MAGE genes on chromosome X. The members of the MAGE-A subfamily are located in the Xq28 region, while the members of the MAGE-B subfamily are clustered in the Xp21 region. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "A0AVE4;B3KQ52;O75861",
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        "go_cellular_component": "GO:0005634 nucleus",
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    {
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        "uniprot_id": [
            {
                "id": "ME15P_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C7V9",
                "type": "external"
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        ],
        "mass": 26716.0,
        "length": 234,
        "protein_name": "Putative methyltransferase-like protein 15P1",
        "gene_name": "METTL15P1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "METTL15P1; METT5D2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative methyltransferase-like protein 15P1; 2.1.1.-; Methyltransferase 5 domain-containing protein 2; Methyltransferase-like protein 15 pseudogene 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
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        "pathway_count": 0,
        "publication_count": 8,
        "publication_id_list": "10737800;24715725;25576301;26154972;26375851;31217245;32938616;33981976",
        "class_list": "",
        "function": "Probable S-adenosyl-L-methionine-dependent methyltransferase., [UniProtKB]",
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        "go_molecular_function": "GO:0071424 rRNA (cytosine-N4-)-methyltransferase activity",
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        "go_biological_process": "GO:0070475 rRNA base methylation",
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    {
        "uniprot_canonical_ac": "P30301-1",
        "uniprot_id": [
            {
                "id": "MIP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P30301",
                "type": "external"
            }
        ],
        "mass": 28122.0,
        "length": 263,
        "protein_name": "Lens fiber major intrinsic protein",
        "gene_name": "MIP",
        "organism": "Human",
        "refseq_name": "lens fiber major intrinsic protein",
        "refseq_ac": [
            {
                "id": "NP_036196",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036196",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MIP; AQP0",
        "gene_names_refseq": "AQP0; CTRCT15; LIM1; MIP26; MIP; MP26",
        "protein_names_uniprotkb": "Lens fiber major intrinsic protein; Aquaporin-0; MIP26; MP26",
        "protein_names_refseq": "aquaporin 0; lens fiber major intrinsic protein",
        "tax_id": 9606,
        "disease": "cataract 15 multiple types (Disease Ontology:DOID:0110251); cataract (Disease Ontology:DOID:83)",
        "pathway": " (hsa:4284);  (R-HSA-432047)",
        "pathway_count": 2,
        "publication_count": 83,
        "publication_id_list": "10067969;10510269;10564231;10634618;10802646;11001937;11027599;11034202;11076974;11231887;11532455;11573934;11952783;12084581;12801959;1373524;14514735;14592814;14701836;1510932;15274640;15703994;15948717;16325777;16407156;16564824;16596446;17178220;17374283;17893667;17920625;17960133;18202181;1840563;18501347;18511455;18555844;18678926;18762715;18768791;18948439;19144687;19170255;19383790;19574955;19590626;19857466;20147624;20361015;21245956;21251984;2176601;22095752;23116563;23359558;24120416;25946197;27339748;27378310;28839118;29914532;3049610;30790544;33141586;34087483;35051231;36360224;36734406;38032258;38153133;38451099;7510718;7530250;7535000;7678419;8140421;8621489;8812490;8855281;9369468;9405233;9806845;9829975",
        "class_list": "",
        "function": "A novel single-base deletional mutation of MIP impairs protein distribution and cell-to-cell adhesion in autosomal dominant cataracts in a Chinese family., [RefSeq, PubMed]; Anterior Umbilication of Lens in a Family with Congenital Cataracts Associated with a Missense Mutation of MIP Gene. Publication Status: Online-Only, [RefSeq, PubMed]; Aquaporins form homotetrameric transmembrane channels, with each monomer independently mediating water transport across the plasma membrane along its osmotic gradient (PubMed:11001937, PubMed:24120416). Specifically expressed in lens fiber cells, this aquaporin is crucial for maintaining lens water homeostasis and transparency. Beyond water permeability, it also acts as a cell-to-cell adhesion molecule, forming thin junctions between lens fiber cells that are essential for maintaining the ordered structure and transparency of the lens (PubMed:24120416)., [UniProtKB, PubMed, PubMed]; First implication of MIP in bilateral microphthalmia with persistent fetal vasculature., [RefSeq, PubMed]; Major intrinsic protein is a member of the water-transporting aquaporins as well as the original member of the MIP family of channel proteins. The function of the fiber cell membrane protein encoded by this gene is undetermined, yet this protein is speculated to play a role in intracellular communication. The MIP protein is expressed in the ocular lens and is required for correct lens function. This gene has been mapped among aquaporins AQP2, AQP5, and AQP6, in a potential gene cluster at 12q13. [provided by RefSeq, Jul 2008]., [RefSeq]; Protective roles of peroxiporins AQP0 and AQP11 in human astrocyte and neuronal cell lines in response to oxidative and inflammatory stressors., [RefSeq, PubMed]; The role of phosphorylation in calmodulin-mediated gating of human AQP0., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "Q17R41",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0015250 water channel activity;GO:0005212 structural constituent of eye lens;GO:0098631 cell adhesion mediator activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0070161 anchoring junction",
        "go_biological_process": "GO:0034109 homotypic cell-cell adhesion;GO:0007601 visual perception;GO:0006833 water transport;GO:0036438 maintenance of lens transparency;GO:1990349 gap junction-mediated intercellular transport",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "P30301-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16048-1",
        "uniprot_id": [
            {
                "id": "MCHL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16048",
                "type": "external"
            }
        ],
        "mass": 9715.0,
        "length": 86,
        "protein_name": "Putative pro-MCH-like protein 1",
        "gene_name": "PMCHL1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "PMCHL1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative pro-MCH-like protein 1; Pro-MCH variant; Pro-melanin-concentrating hormone-like protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "sleeping sickness (Disease Ontology:DOID:10112); obesity (Disease Ontology:DOID:9970)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 4,
        "publication_id_list": "11070051;11181993;8326825;9729295",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9BQ10",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030354 melanin-concentrating hormone activity;GO:0031777 type 1 melanin-concentrating hormone receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0045202 synapse",
        "go_biological_process": "GO:0007268 chemical synaptic transmission;GO:0032227 negative regulation of synaptic transmission, dopaminergic",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q16048-1",
        "record_type": "protein",
        "filter_code": "0000000.0000110.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q4G0A6-1",
        "uniprot_id": [
            {
                "id": "MINY4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q4G0A6",
                "type": "external"
            }
        ],
        "mass": 84372.0,
        "length": 757,
        "protein_name": "Probable ubiquitin carboxyl-terminal hydrolase MINDY-4",
        "gene_name": "MINDY4",
        "organism": "Human",
        "refseq_name": "probable ubiquitin carboxyl-terminal hydrolase MINDY-4",
        "refseq_ac": [
            {
                "id": "NP_115598",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115598",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MINDY4; C7orf67; FAM188B",
        "gene_names_refseq": "C7orf67; FAM188B; MINDY4",
        "protein_names_uniprotkb": "Probable ubiquitin carboxyl-terminal hydrolase MINDY-4; 3.4.19.12; Probable deubiquitinating enzyme MINDY-4",
        "protein_names_refseq": "MINDY deubiquitinase 4; Urine water channel; Water channel protein for red blood cells and kidney proximal tubule; family with sequence similarity 188 member B; probable deubiquitinating enzyme MINDY-4; probable ubiquitin carboxyl-terminal hydrolase FAM188B; probable ubiquitin carboxyl-terminal hydrolase MINDY-4; protein FAM188B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84182)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "18452278;19562805;19913121;20628086;23186163;24715725;25645385;25892735;26154972;26758079;27600516;27920218;28218747;28904123;29242379;29437277;29557506;29769354;29786170;29795372;30315122;30377343;30410026;30779550;31717259;31844290;31848261;32157095;32357974;32387766;32488085;32938616;33298915;33968037;34171305;34405274;34509645;35051231;36010968;36241641",
        "class_list": "",
        "function": "FAM188B is a putative oncogene that functions via interaction with USP7. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Probable hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q71AZ7;Q9H6D2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004843 cysteine-type deubiquitinase activity;GO:1990380 K48-linked deubiquitinase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0006508 proteolysis;GO:0071108 protein K48-linked deubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q4G0A6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q504T8-1",
        "uniprot_id": [
            {
                "id": "MIDN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q504T8",
                "type": "external"
            }
        ],
        "mass": 49213.0,
        "length": 468,
        "protein_name": "Midnolin",
        "gene_name": "MIDN",
        "organism": "Human",
        "refseq_name": "midnolin isoform 2",
        "refseq_ac": [
            {
                "id": "NP_796375",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_796375",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MIDN",
        "gene_names_refseq": "MIDN; Stx",
        "protein_names_uniprotkb": "Midnolin; Midbrain nucleolar protein",
        "protein_names_refseq": "midbrain nucleolar protein; midnolin isoform 2; stuxnet homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:90007)",
        "pathway_count": 1,
        "publication_count": 55,
        "publication_id_list": "11237011;23481700;24187134;24714562;24715725;25418920;25576301;26154972;26728094;26811146;26992070;27846572;27920218;28446606;28724963;28832583;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;31588691;31844290;32157095;32350084;32387766;32488085;32502341;32938616;32983136;33123756;33141586;33298915;33592498;33691108;33912179;33936100;34087483;34171305;34211107;35051231;35251023;35318648;35580925;36010968;36284347;36858566;37217939;37616343",
        "class_list": "",
        "function": "Facilitates the ubiquitin-independent proteasomal degradation of stimulus-induced transcription factors such as FOSB, EGR1, NR4A1, and IRF4 to the proteasome for degradation (PubMed:37616343). Promotes also the degradation of other substrates such as CBX4 (By similarity). Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; MIDN promotes the expression of parkin E3 ubiquitin ligase, and that MIDN loss can trigger Parkinson's disease-related pathogenic mechanisms. Publication Status: Online-Only, [RefSeq, PubMed]; Midnolin is a confirmed genetic risk factor for Parkinson's disease., [RefSeq, PubMed]; Midnolin plays a role in cellular signaling of adult tissues and regulates glucokinase enzyme activity in pancreatic beta cells, [RefSeq, PubMed]; Structural Variants of Midnolin, a Genetic Risk Factor for Parkinson's Disease, in a Yamagata Cohort., [RefSeq, PubMed]; The midnolin-proteasome pathway catches proteins for ubiquitination-independent degradation., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96BW8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0019900 kinase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0046676 negative regulation of insulin secretion;GO:0033132 negative regulation of glucokinase activity;GO:0010499 proteasomal ubiquitin-independent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "Q504T8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5JXM2-1",
        "uniprot_id": [
            {
                "id": "MET24_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5JXM2",
                "type": "external"
            }
        ],
        "mass": 41330.0,
        "length": 366,
        "protein_name": "Probable methyltransferase-like protein 24",
        "gene_name": "METTL24",
        "organism": "Human",
        "refseq_name": "probable methyltransferase-like protein 24 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001116836",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001116836",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL24; C6orf186",
        "gene_names_refseq": "C6orf186; METTL24",
        "protein_names_uniprotkb": "Probable methyltransferase-like protein 24; 2.1.1.-",
        "protein_names_refseq": "UPF0624 protein C6orf186; probable methyltransferase-like protein 24 isoform 1 precursor; probable methyltransferase-like protein 24",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:728464)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "29729188;30459171;36311770",
        "class_list": "",
        "function": "A comprehensive investigation discovered the novel methyltransferase METTL24 as one presumably prognostic gene for kidney renal clear cell carcinoma potentially modulating tumor immune microenvironment. Publication Status: Online-Only, [RefSeq, PubMed]; Probable methyltransferase., [UniProtKB]; The strongest DNA methylation changes in atopic asthma were detected in the promoter region of SMAD3 gene at chr 15q22.33 and introns of DDO/METTL24 genes at 6q21., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 1,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
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        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ZSU5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008168 methyltransferase activity",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "Q5JXM2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UB28-1",
        "uniprot_id": [
            {
                "id": "MAP12_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UB28",
                "type": "external"
            }
        ],
        "mass": 37088.0,
        "length": 335,
        "protein_name": "Methionine aminopeptidase 1D, mitochondrial",
        "gene_name": "METAP1D",
        "organism": "Human",
        "refseq_name": "methionine aminopeptidase 1D, mitochondrial isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001309207",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001309207",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METAP1D; MAP1D",
        "gene_names_refseq": "MAP 1D; MAP1D; METAP1D; MetAP 1D; Metap1l",
        "protein_names_uniprotkb": "Methionine aminopeptidase 1D, mitochondrial; 3.4.11.18; MAP 1D; MetAP 1D; Methionyl aminopeptidase type 1D, mitochondrial; Peptidase M 1D",
        "protein_names_refseq": "CDS of metAP-3 within PCR fragment; metAP 1D; methionine aminopeptidase 1D, mitochondrial isoform 2; methionine aminopeptidase 1D, mitochondrial; peptidase M 1D",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:254042)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "14532271;16568094;17929833;19913121;20628086;20877624;28904123;31217245;31844290;35051231;36241641;38102161;39894887",
        "class_list": "",
        "function": "MAP1D is a potentially oncogenic, novel member of the MAP gene family that may play an important role in colon tumorigenesis, [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed (By similarity). May play a role in colon tumorigenesis., [UniProtKB, PubMed, HAMAP]; Structural insights into N-terminal methionine cleavage by the human mitochondrial methionine aminopeptidase, MetAP1D. Publication Status: Online-Only, [RefSeq, PubMed]; The N-terminal methionine excision pathway is an essential process in which the N-terminal methionine is removed from many proteins, thus facilitating subsequent protein modification. In mitochondria, enzymes that catalyze this reaction are celled methionine aminopeptidases (MetAps, or MAPs; EC 3.4.11.18) (Serero et al., 2003 [PubMed 14532271]).[supplied by OMIM, Mar 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q1WNX3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity;GO:0070006 metalloaminopeptidase activity;GO:0004239 initiator methionyl aminopeptidase activity",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "GO:0006508 proteolysis;GO:0043687 post-translational protein modification",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q6UB28-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZNC8-1",
        "uniprot_id": [
            {
                "id": "MBOA1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZNC8",
                "type": "external"
            }
        ],
        "mass": 56557.0,
        "length": 495,
        "protein_name": "Membrane-bound glycerophospholipid O-acyltransferase 1",
        "gene_name": "MBOAT1",
        "organism": "Human",
        "refseq_name": "membrane-bound glycerophospholipid O-acyltransferase 1",
        "refseq_ac": [
            {
                "id": "NP_001073949",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073949",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MBOAT1; OACT1",
        "gene_names_refseq": "LPEAT1; LPLAT 1; LPLAT14; LPLAT; LPSAT; MBOAT1; OACT1; dJ434O11.1",
        "protein_names_uniprotkb": "Membrane-bound glycerophospholipid O-acyltransferase 1; 1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase; 2.3.1.-; 2.3.1.23; 2.3.1.n6; 2.3.1.n7; LPLAT 1; LPSAT; Lyso-PS acyltransferase; Lysophosphatidylserine acyltransferase; Lysophospholipid acyltransferase 1; Membrane-bound O-acyltransferase domain-containing protein 1; O-acyltransferase domain-containing protein 1",
        "protein_names_refseq": "1-acylglycerophosphocholine O-acyltransferase; 1-acylglycerophosphoethanolamine O-acyltransferase; 1-acylglycerophosphoserine O-acyltransferase MBOAT1; 1-acylglycerophosphoserine O-acyltransferase; O-acyltransferase (membrane bound) domain containing 1; lyso-PS acyltransferase; lysophosphatidylethanolamine acyltransferase 1; lysophosphatidylserine acyltransferase; lysophospholipid acyltransferase 14; lysophospholipid acyltransferase 1; membrane bound O-acyltransferase domain containing 1; membrane-bound O-acyltransferase domain-containing protein 1; membrane-bound glycerophospholipid O-acyltransferase 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:154141);  (R-HSA-1482801);  (R-HSA-1482839)",
        "pathway_count": 3,
        "publication_count": 50,
        "publication_id_list": "10092647;10196188;10336645;10455175;10681567;11031251;11112443;11830583;12161451;12359733;12522102;15695510;15863501;15944408;16617059;16818490;17101204;17890783;18195019;18287005;18458083;18614531;18772128;18781350;19019078;19351971;19501189;19554302;20705608;21220512;21406692;22605381;22825852;22906437;23186163;23934110;26206935;26503625;26992070;28904123;2925608;2925633;34087483;34596601;35051231;35580925;7060561;8300559;9188469;9417066",
        "class_list": "",
        "function": "Acyltransferase which catalyzes the transfer of an acyl group from an acyl-CoA towards a lysophospholipid producing a phospholipid and participates in the reacylation step of the phospholipid remodeling pathway also known as the Lands cycle (PubMed:18772128). Acts on lysophosphatidylserine (1-acyl-2-hydroxy-sn-glycero-3-phospho-L-serine or LPS) and lysophosphatidylethanolamine (1-acyl-sn-glycero-3-phosphoethanolamine or LPE), and to a lesser extend lysophosphatidylcholine (PubMed:18772128). Prefers oleoyl-CoA as the acyl donor and 1-oleoyl-LPE as acceptor (PubMed:18772128). May play a role in neurite outgrowth during neuronal differentiation (By similarity)., [UniProtKB, UniProtKB, PubMed]; MBOAT1 homozygous missense variant causes nonobstructive azoospermia., [RefSeq, PubMed]; This gene belongs to the membrane-bound O-acetyltransferase superfamily. The encoded transmembrane protein is an enzyme that transfers organic compounds, preferably from oleoyl-CoA, to hydroxyl groups of protein targets in membranes. A translocation disrupting this gene may be associated with brachydactyly syndactyly syndrome. Alternately spliced transcript variants have been described for this gene. [provided by RefSeq, Nov 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A9EDQ5;B4DL59;B4E3J4;Q86XC2;Q8N9R5",
        "ec_number_list": [
            {
                "id": "1.11.1.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.27",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
            },
            {
                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
                "type": "external"
            },
            {
                "id": "2.3.1.121",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.121",
                "type": "external"
            },
            {
                "id": "2.3.1.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67",
                "type": "external"
            },
            {
                "id": "2.3.1.n6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n6",
                "type": "external"
            },
            {
                "id": "2.3.1.n7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.n7",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.51",
                "type": "external"
            },
            {
                "id": "2.3.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25",
                "type": "external"
            },
            {
                "id": "2.3.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.22",
                "type": "external"
            },
            {
                "id": "2.3.1.62",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.62",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0047144 2-acylglycerol-3-phosphate O-acyltransferase activity;GO:0003841 1-acylglycerol-3-phosphate O-acyltransferase activity;GO:0047184 1-acylglycerophosphocholine O-acyltransferase activity;GO:0016746 acyltransferase activity;GO:0106262 1-acylglycerophosphoethanolamine O-acyltransferase activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0036152 phosphatidylethanolamine acyl-chain remodeling;GO:0010975 regulation of neuron projection development;GO:0008654 phospholipid biosynthetic process;GO:0036150 phosphatidylserine acyl-chain remodeling;GO:0030258 lipid modification",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q6ZNC8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q70IA6-1",
        "uniprot_id": [
            {
                "id": "MOB2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q70IA6",
                "type": "external"
            }
        ],
        "mass": 26927.0,
        "length": 237,
        "protein_name": "MOB kinase activator 2",
        "gene_name": "MOB2",
        "organism": "Human",
        "refseq_name": "MOB kinase activator 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001165694",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165694",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MOB2; HCCA2",
        "gene_names_refseq": "HCCA2; MOB2",
        "protein_names_uniprotkb": "MOB kinase activator 2; HCCA2; Mob2 homolog; Mps one binder kinase activator-like 2",
        "protein_names_refseq": "MOB kinase activator 2 isoform 1; MOB2 Mps One Binder homolog; Mps one binder kinase activator-like 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:81532)",
        "pathway_count": 1,
        "publication_count": 35,
        "publication_id_list": "15067004;20624913;23326134;25460043;25880248;25892735;26992070;27600516;28228285;28832583;28834231;28904123;29493099;29557506;29632711;29769354;30315122;31154438;31844290;31848261;32157095;32286266;32357974;32897882;32938616;33717175;33968037;33981976;35051231;35561310;35580925;36284347;36581221;37938771;38665916",
        "class_list": "",
        "function": "Binds to and stimulates the kinase activity of the related human serine-threonine kinases NDR1 and NDR2., [RefSeq, PubMed]; Data indicate that human MOB2 is a negative regulator of human NDR kinases in biochemical and biological settings., [RefSeq, PubMed]; HMOB2 interacts with RAD50, facilitating the recruitment of the MRE11-RAD50-NBS1 (MRN) DNA damage sensor complex and activated ATM to DNA damaged chromatin., [RefSeq, PubMed]; MOB2 overexpression induces apoptosis and inhibits the growth of human hepatic cancer cells, [RefSeq, PubMed]; MOB2 suppresses GBM cell migration and invasion via regulation of FAK/Akt and cAMP/PKA signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Stimulates the autophosphorylation and kinase activity of STK38 and STK38L., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DKP3;Q96M67",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0030295 protein kinase activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "Q70IA6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86UD3-1",
        "uniprot_id": [
            {
                "id": "MARH3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86UD3",
                "type": "external"
            }
        ],
        "mass": 28504.0,
        "length": 253,
        "protein_name": "E3 ubiquitin-protein ligase MARCHF3",
        "gene_name": "MARCHF3",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase MARCHF3",
        "refseq_ac": [
            {
                "id": "NP_848545",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_848545",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MARCHF3; MARCH3; RNF173",
        "gene_names_refseq": "MARCH-III; MARCH3; MARCHF3; RNF173",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MARCHF3; 2.3.2.27; MARCH-III; Membrane-associated RING finger protein 3; Membrane-associated RING-CH protein III; RING finger protein 173; RING-type E3 ubiquitin transferase MARCHF3",
        "protein_names_refseq": "E3 ubiquitin-protein ligase MARCH3; E3 ubiquitin-protein ligase MARCHF3; RING finger protein 173; RING-type E3 ubiquitin transferase MARCH3; RING-type E3 ubiquitin transferase MARCHF3; membrane associated ring finger 3; membrane-associated RING-CH protein III; membrane-associated ring finger (C3HC4) 3, E3 ubiquitin protein ligase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:115123)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "16428329;23186163;26694610;27616439;30379171;31844290;32350084;35154160;35251023;37626338",
        "class_list": "",
        "function": "E3 ubiquitin-protein ligase which may be involved in endosomal trafficking. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer the ubiquitin to targeted substrates., [UniProtKB, UniProtKB]; LPS activation of TLR4 significantly increased MARCH3 expression and that siRNA against MARCH3 prevented the decrease in FcgammaRIIb following LPS treatment., [RefSeq, PubMed]; RNF173 suppresses RAF/MEK/ERK signaling to regulate invasion and metastasis via GRB2 ubiquitination in Hepatocellular Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Report shows that silencing MARCH3 protects the endothelial barrier and upregulates OCLN in MARCH3-depleted cells. MARCH3 silencing results in the strengthening of cell-cell contacts and inactivates FoxO1., [RefSeq, PubMed]; This gene encodes a member of the membrane-associated RING-CH (MARCH) family. The encoded protein is an E3 ubiquitin-protein ligase that may be involved in regulation of the endosomal transport pathway. [provided by RefSeq, Mar 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K264;B9EJE7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0004842 ubiquitin-protein transferase activity",
        "go_cellular_component": "GO:0005768 endosome;GO:0005764 lysosome;GO:0031901 early endosome membrane",
        "go_biological_process": "GO:0006897 endocytosis;GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q86UD3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N4V1-1",
        "uniprot_id": [
            {
                "id": "EMC5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N4V1",
                "type": "external"
            }
        ],
        "mass": 14686.0,
        "length": 131,
        "protein_name": "ER membrane protein complex subunit 5",
        "gene_name": "MMGT1",
        "organism": "Human",
        "refseq_name": "ER membrane protein complex subunit 5",
        "refseq_ac": [
            {
                "id": "NP_001316929",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001316929",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MMGT1; EMC5; TMEM32",
        "gene_names_refseq": "EMC5; MMGT1; TMEM32",
        "protein_names_uniprotkb": "ER membrane protein complex subunit 5; Membrane magnesium transporter 1; Transmembrane protein 32",
        "protein_names_refseq": "ER membrane protein complex subunit 5; transmembrane protein 32",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:93380);  (R-HSA-5223345)",
        "pathway_count": 2,
        "publication_count": 68,
        "publication_id_list": "10.1101/2023.09.13.557529;10571941;11237011;11326272;11326338;11401429;12297987;12297989;12951058;13130483;14984739;15804357;17166836;18057121;18347014;1840603;18578522;18669648;18930737;19262752;1955075;19717468;20068231;22119785;22649030;23169667;23186163;24725410;24790029;25576301;25645385;26620797;26635246;26824658;27102039;27600516;27862975;28228285;28832583;28834231;28904123;29242231;29809151;30315122;30415835;31844290;32157095;32350084;32357974;32387766;32439656;32459176;32938616;33912179;33968037;34171305;34509645;35051231;36010968;36215666;36241641;37074911;4018271;7615546;7619062;7749638;9114041;9537412",
        "class_list": "",
        "function": "Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 9507,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R625;B4DIY3;D3DWG7;Q5JPP7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0015087 cobalt ion transmembrane transporter activity;GO:0015093 ferrous iron transmembrane transporter activity;GO:0015095 magnesium ion transmembrane transporter activity",
        "go_cellular_component": "GO:0072546 EMC complex;GO:0000139 Golgi membrane;GO:0005769 early endosome;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0015693 magnesium ion transport;GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "Q8N4V1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TD46-4",
        "uniprot_id": [
            {
                "id": "MO2R1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TD46",
                "type": "external"
            }
        ],
        "mass": 39041.0,
        "length": 348,
        "protein_name": "Cell surface glycoprotein CD200 receptor 1",
        "gene_name": "CD200R1",
        "organism": "Human",
        "refseq_name": "cell surface glycoprotein CD200 receptor 1 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_620161",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_620161",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CD200R1; CD200R; CRTR2; MOX2R; OX2R; PRO6015",
        "gene_names_refseq": "CD200R1; CD200R; HCRTR2; MOX2R; OX2R",
        "protein_names_uniprotkb": "Cell surface glycoprotein CD200 receptor 1; CD200 cell surface glycoprotein receptor; Cell surface glycoprotein OX2 receptor 1",
        "protein_names_refseq": "CD200 cell surface glycoprotein receptor; MOX2 receptor; cell surface glycoprotein CD200 receptor 1 isoform a precursor; cell surface glycoprotein CD200 receptor 1; cell surface glycoprotein OX2 receptor 1; cell surface glycoprotein receptor CD200",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:131450);  (R-HSA-198933)",
        "pathway_count": 2,
        "publication_count": 91,
        "publication_id_list": "10499918;10746781;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12213321;12483297;12588680;12960329;12975309;14719373;14970179;15034010;15136729;15155468;15187158;15274657;15304001;15340161;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;16014749;16091383;16129954;16339513;16380601;16551255;16737824;16754721;16893496;16904340;16928187;17045824;17057721;17237375;17337780;18031695;18037897;18055229;18209062;18234675;18593354;19149696;19359216;19592130;20730098;21241660;21800138;21841309;21877119;22396535;23695528;23929856;24190977;24305946;24388216;25703557;25716998;26284469;26300885;37074911;37616575;38253038;38354085;38692160;38745652;39294682;40914422;7531291;7542404;8178173;8995416;9285412;9314561;9700512;9730896",
        "class_list": "",
        "function": "CD200R promotes high glucose-induced oxidative stress and damage in human retinal pigment epithelial cells by activating the mTOR signaling pathway., [RefSeq, PubMed]; Exploiting the CD200-CD200R immune checkpoint axis in multiple myeloma to enhance CAR T-cell therapy., [RefSeq, PubMed]; Inflammatory dendritic cells restrain CD11b[+]CD4[+] CTLs via CD200R in human NSCLC., [RefSeq, PubMed]; Inhibitory receptor for the CD200/OX2 cell surface glycoprotein. Limits inflammation by inhibiting the expression of pro-inflammatory molecules including TNF, interferons, and inducible nitric oxide synthase (iNOS) in response to selected stimuli. Also binds to HHV-8 K14 viral CD200 homolog with identical affinity and kinetics as the host CD200., [UniProtKB, PubMed]; Myeloid cell expression of CD200R is modulated in active TB disease and regulates Mycobacterium tuberculosis infection in a biomimetic model. Publication Status: Online-Only, [RefSeq, PubMed]; The regulation of NFKB1 on CD200R1 expression and their potential roles in Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a receptor for the OX-2 membrane glycoprotein. Both the receptor and substrate are cell surface glycoproteins containing two immunoglobulin-like domains. This receptor is restricted to the surfaces of myeloid lineage cells and the receptor-substrate interaction may function as a myeloid downregulatory signal. Mouse studies of a related gene suggest that this interaction may control myeloid function in a tissue-specific manner. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
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        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 5,
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        "reported_snv": 28,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 10,
        "disease_count": 0,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWZ9;E9PCM9;Q52LJ7;Q6IS95;Q6UW94;Q6WHB8;Q8TD44;Q8TD45;Q8TD52",
        "ec_number_list": [],
        "go_molecular_function": "GO:0038023 signaling receptor activity;GO:0019763 immunoglobulin receptor activity;GO:0140081 glycosylated region protein binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0043235 receptor complex;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:1905522 negative regulation of macrophage migration;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0032715 negative regulation of interleukin-6 production;GO:2000405 negative regulation of T cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q8TD46-4",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BRJ9-1",
        "uniprot_id": [
            {
                "id": "MESP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BRJ9",
                "type": "external"
            }
        ],
        "mass": 28501.0,
        "length": 268,
        "protein_name": "Mesoderm posterior protein 1",
        "gene_name": "MESP1",
        "organism": "Human",
        "refseq_name": "mesoderm posterior protein 1",
        "refseq_ac": [
            {
                "id": "NP_061140",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061140",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MESP1; BHLHC5",
        "gene_names_refseq": "MESP1; bHLHc5",
        "protein_names_uniprotkb": "Mesoderm posterior protein 1; Class C basic helix-loop-helix protein 5; bHLHc5",
        "protein_names_refseq": "class C basic helix-loop-helix protein 5; mesoderm posterior 1 homolog; mesoderm posterior basic helix-loop-helix transcription factor 1; mesoderm posterior protein 1",
        "tax_id": 9606,
        "disease": "myocardial infarction (Disease Ontology:DOID:5844); diabetic retinopathy (Disease Ontology:DOID:8947)",
        "pathway": " (hsa:55897);  (R-HSA-9733709)",
        "pathway_count": 2,
        "publication_count": 17,
        "publication_id_list": "15095414;15122512;18297060;19479054;22826236;25187301;26783251;29493099;29636455;30315122;30389344;30410026;31761621;32157095;33054971;36413948;37271034",
        "class_list": "",
        "function": "Essential role of MESP1-RING1A complex in cardiac differentiation., [RefSeq, PubMed]; MESP1-knockdown inhibits the proliferation and epithelial mesenchymal transition of hepatocellular carcinoma and enhances the tumor-suppressive effect of 5-fluorouracil., [RefSeq, PubMed]; MesP1 drives vertebrate cardiovascular differentiation through Dkk-1-mediated blockade of Wnt-signalling, [RefSeq, PubMed]; Study demonstrates that while leaving primitive streak markers unaffected, MESP1 expression is required for timely vascular progenitor specification. Thus, MESP1 expression is essential for the molecular features of early CM, EC and VSMC lineage specification., [RefSeq, PubMed]; Transcription factor. Plays a role in the epithelialization of somitic mesoderm and in the development of cardiac mesoderm. Defines the rostrocaudal patterning of the somites by participating in distinct Notch pathways (By similarity)., [UniProtKB]; Transcription factors ETS2 and MESP1 transdifferentiate human dermal fibroblasts into cardiac progenitors., [RefSeq, PubMed]; We demonstrate that upregulation of MESP1, a key tumor-promoting alteration, functions to create tumor dependency on an inbuilt lineage-survival process. MESP1, being the nodal point of this survival process, sustains the tumor dependency by transcriptionally activating key genes involved in tumor cell initiation, proliferation and progression including EMT, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
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        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9NSF1;Q9NSF2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0046983 protein dimerization activity;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0060913 cardiac cell fate determination;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007219 Notch signaling pathway;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q9BRJ9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H9K5-1",
        "uniprot_id": [
            {
                "id": "MER34_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H9K5",
                "type": "external"
            }
        ],
        "mass": 63547.0,
        "length": 563,
        "protein_name": "Endogenous retroviral envelope protein HEMO",
        "gene_name": "ERVMER34-1",
        "organism": "Human",
        "refseq_name": "endogenous retroviral envelope protein HEMO precursor",
        "refseq_ac": [
            {
                "id": "NP_001229619",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229619",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ERVMER34-1; HEMO; LP9056",
        "gene_names_refseq": "ERVMER34-1; HEMO; envMER34",
        "protein_names_uniprotkb": "Endogenous retroviral envelope protein HEMO; Endogenous retroviral envelope protein HEMO, 48 kDa form; Endogenous retrovirus group MER34 member 1 Env polyprotein; HEMO; HERV-MER_4q12 provirus ancestral Env polyprotein; Human endogenous MER34 (medium-reiteration-frequency-family-34) open reading frame; Human endogenous MER34 ORF",
        "protein_names_refseq": "HERV-MER_4q12 provirus ancestral Env polyprotein; Human Endogenous MEdium-Reiteration-frequency-family-34 ORF; LP9056 protein; endogenous MER34 (medium-reiteration-frequency-family-34) ORF; endogenous retroviral envelope protein HEMO precursor; endogenous retroviral envelope protein HEMO; endogenous retrovirus group MER34 member 1 Env polyprotein; endogenous retrovirus group MER34, member 1; human endogenous MER34 ORF",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100288413)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "10.1038/emboj.2013.79;15498874;23090970;23584533;24190977;28739914;29242379;29393594;32350084;33392160;35051231;35251023;37074911",
        "class_list": "",
        "function": "Endogenous envelope proteins originate from retroviral envelope proteins, which mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution., [UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 2,
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        "reported_snv": 37,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 0,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KTB4;Q0P5R3;Q6NWN0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "Q9H9K5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9P2G4-1",
        "uniprot_id": [
            {
                "id": "MAP10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9P2G4",
                "type": "external"
            }
        ],
        "mass": 100345.0,
        "length": 905,
        "protein_name": "Microtubule-associated protein 10",
        "gene_name": "MAP10",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "MAP10; KIAA1383; MTR120",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Microtubule-associated protein 10; Microtubule regulator of 120 KDa",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54627)",
        "pathway_count": 1,
        "publication_count": 30,
        "publication_id_list": "23264731;23481700;25892735;28218747;28514659;28832583;28904123;29242379;29437277;29508533;29741879;29769354;30315122;30379171;31154438;31844290;32387766;32897882;32938616;33141586;33298915;33392160;33592498;33717175;33912179;33968037;34509645;35051231;36284347;36581221",
        "class_list": "",
        "function": "Microtubule-associated protein (MAP) that plays a role in the regulation of cell division; promotes microtubule stability and participates in the organization of the spindle midzone and normal progress of cytokinesis., [UniProtKB, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
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        "glycan_count": 12,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2F1;Q32MI1;Q58EZ9;Q5VV83",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005813 centrosome;GO:0030496 midbody;GO:0005881 cytoplasmic microtubule;GO:0097431 mitotic spindle pole;GO:1990023 mitotic spindle midzone",
        "go_biological_process": "GO:0051301 cell division;GO:0032886 regulation of microtubule-based process;GO:0032467 positive regulation of cytokinesis;GO:0051256 mitotic spindle midzone assembly;GO:0031122 cytoplasmic microtubule organization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q9P2G4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0C5B5G6-1",
        "uniprot_id": [
            {
                "id": "MOTSC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A0C5B5G6",
                "type": "external"
            }
        ],
        "mass": 2175.0,
        "length": 16,
        "protein_name": "Mitochondrial-derived peptide MOTS-c",
        "gene_name": "MT-RNR1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "MT-RNR1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Mitochondrial-derived peptide MOTS-c; Mitochondrial open reading frame of the 12S rRNA-c",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 16,
        "publication_id_list": "25738459;26289118;29096170;29886458;29983246;30468456;30725119;31081069;31369811;31694019;31931370;32182209;33468709;33473109;33554779;7219534",
        "class_list": "",
        "function": "Regulates insulin sensitivity and metabolic homeostasis (PubMed:25738459, PubMed:33468709). Inhibits the folate cycle, thereby reducing de novo purine biosynthesis which leads to the accumulation of the de novo purine synthesis intermediate 5-aminoimidazole-4-carboxamide (AICAR) and the activation of the metabolic regulator 5'-AMP-activated protein kinase (AMPK) (PubMed:25738459). Protects against age-dependent and diet-induced insulin resistance as well as diet-induced obesity (PubMed:25738459). In response to metabolic stress, translocates to the nucleus where it binds to antioxidant response elements (ARE) present in the promoter regions of a number of genes and plays a role in regulating nuclear gene expression in an NFE2L2-dependent manner and increasing cellular resistance to metabolic stress (PubMed:29983246). Increases mitochondrial respiration and levels of CPT1A and cytokines IL1B, IL6, IL8, IL10 and TNF in senescent cells (PubMed:29886458). Increases activity of the serine/threonine protein kinase complex mTORC2 and reduces activity of the PTEN phosphatase, thus promoting phosphorylation of AKT (PubMed:33554779). This promotes AKT-mediated phosphorylation of transcription factor FOXO1 which reduces FOXO1 activity, leading to reduced levels of MSTN and promotion of skeletal muscle growth (PubMed:33554779). Promotes osteogenic differentiation of bone marrow mesenchymal stem cells via the TGFB/SMAD pathway (PubMed:30468456). Promotes osteoblast proliferation and osteoblast synthesis of type I collagens COL1A1 and COL1A2 via the TGFB/SMAD pathway (PubMed:31081069)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "reported_mutagensis": 4,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0140297 DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005739 mitochondrion",
        "go_biological_process": "GO:0033687 osteoblast proliferation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0048630 skeletal muscle tissue growth;GO:0032147 activation of protein kinase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "A0A0C5B5G6-1",
        "record_type": "protein",
        "filter_code": "0000000.0100100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NGR9-1",
        "uniprot_id": [
            {
                "id": "MROH6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NGR9",
                "type": "external"
            }
        ],
        "mass": 77186.0,
        "length": 719,
        "protein_name": "Maestro heat-like repeat-containing protein family member 6",
        "gene_name": "MROH6",
        "organism": "Human",
        "refseq_name": "maestro heat-like repeat-containing protein family member 6",
        "refseq_ac": [
            {
                "id": "NP_001094348",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094348",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MROH6; C8orf73",
        "gene_names_refseq": "C8orf73; MROH6",
        "protein_names_uniprotkb": "Maestro heat-like repeat-containing protein family member 6",
        "protein_names_refseq": "maestro heat-like repeat-containing protein family member 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:642475)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "11237011;25645385;26992070;29242379;29557506;30524438;31844290;32157095;32897882;32938616;33968037;33981976;34185709;35051231;35580925;36241641",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MWB1",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "A6NGR9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IVN3-1",
        "uniprot_id": [
            {
                "id": "MSTN1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IVN3",
                "type": "external"
            }
        ],
        "mass": 8911.0,
        "length": 82,
        "protein_name": "Musculoskeletal embryonic nuclear protein 1",
        "gene_name": "MUSTN1",
        "organism": "Human",
        "refseq_name": "musculoskeletal embryonic nuclear protein 1",
        "refseq_ac": [
            {
                "id": "NP_995325",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995325",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MUSTN1",
        "gene_names_refseq": "MUSTANG; MUSTN1",
        "protein_names_uniprotkb": "Musculoskeletal embryonic nuclear protein 1",
        "protein_names_refseq": "musculoskeletal embryonic nuclear protein 1; musculoskeletal temporally activated novel",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:389125)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "11237011;17519359;38458566;39894887",
        "class_list": "",
        "function": "CSRP3, MUSTN1, SIX1, and FBXO32 expression changes in response to lengthening and shortening contractions in human muscle, [RefSeq, PubMed]; Required for chondrocyte development and proliferation. Plays a role in myoblast differentiation and fusion. Modulates skeletal muscle extracellular matrix composition. Plays a role in skeletal muscle function. Plays a role in glucose homeostasis., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
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        "total_reported_o_glycosites": 1,
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        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
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        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007517 muscle organ development;GO:0030326 embryonic limb morphogenesis;GO:0042593 glucose homeostasis;GO:0042246 tissue regeneration;GO:0002062 chondrocyte differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "Q8IVN3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "E2RYF6-1",
        "uniprot_id": [
            {
                "id": "MUC22_HUMAN",
                "url": "https://www.uniprot.org/uniprot/E2RYF6",
                "type": "external"
            }
        ],
        "mass": 173478.0,
        "length": 1773,
        "protein_name": "Mucin-22",
        "gene_name": "MUC22",
        "organism": "Human",
        "refseq_name": "mucin-22 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001185744",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001185744",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MUC22; G4; PBMUCL1",
        "gene_names_refseq": "MUC22; PBMUCL1",
        "protein_names_uniprotkb": "Mucin-22; Panbronchiolitis-related mucin-like protein 1",
        "protein_names_refseq": "mucin-22 isoform 2 precursor; panbronchiolitis-related mucin-like protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100507679)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "20981447;28262390;33786615;34171305;35051231;35580925;36389712",
        "class_list": "",
        "function": "Differential MUC22 expression by epigenetic alterations in human lung squamous cell carcinoma and adenocarcinoma., [RefSeq, PubMed]; Genes TGFB1, TLE4 and MUC22 are associated with the risk of childhood asthma in Chinese population., [RefSeq, PubMed]; MUC22, HLA-A, and HLA-DOB variants and COVID-19 in resilient super-agers from Brazil. Publication Status: Online-Only, [RefSeq, PubMed]; The mucin-like gene PBMUCL1 is also one of the candidate genes of Diffuse panbronchiolitis susceptibility., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 60,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "H3BQR8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "E2RYF6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P07438-1",
        "uniprot_id": [
            {
                "id": "MT1B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P07438",
                "type": "external"
            }
        ],
        "mass": 6115.0,
        "length": 61,
        "protein_name": "Metallothionein-1B",
        "gene_name": "MT1B",
        "organism": "Human",
        "refseq_name": "metallothionein-1B",
        "refseq_ac": [
            {
                "id": "NP_005938",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005938",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MT1B; MT1Q",
        "gene_names_refseq": "MT-1B; MT-IB; MT1B; MT1Q; MT1; MTP",
        "protein_names_uniprotkb": "Metallothionein-1B; MT-1B; MT-IB; Metallothionein-IB",
        "protein_names_refseq": "metallothionein 1B (functional); metallothionein 1Q; metallothionein-1B; metallothionein-IB",
        "tax_id": 9606,
        "disease": "retinitis pigmentosa (Disease Ontology:DOID:10584); Alzheimer's disease (Disease Ontology:DOID:10652); kidney failure (Disease Ontology:DOID:1074); transient cerebral ischemia (Disease Ontology:DOID:224); median neuropathy (Disease Ontology:DOID:571)",
        "pathway": " (hsa:4490);  (R-HSA-5661231)",
        "pathway_count": 2,
        "publication_count": 35,
        "publication_id_list": "10542048;10716985;10830841;11237011;11994011;12072966;12911326;12963354;15033980;15698955;15736926;15747776;16984198;17224279;17388808;17389590;18157556;18429853;18454142;18491316;18533113;19425569;20463663;20711450;21320589;22242602;22283439;22823575;22982309;23086305;23506369;23523794;24973778;36215666;3785191",
        "class_list": "",
        "function": "Eight MT genes were up-regulated after treatment of T-ALL cells with 0.15 and 1.5 microg/mL of metal ores. Copper/cadmium/zinc ore binding., [RefSeq, PubMed]; Metallothioneins have a high content of cysteine residues that bind various heavy metals., [UniProtKB, UniProtKB]; Metallothioneins have a high content of cysteine residues that bind various heavy metals; these proteins are transcriptionally regulated by both heavy metals and glucocorticoids., [UniProtKB]; The protein encoded by this gene binds heavy metals and protects against toxicity from heavy metal ions. This gene is found in a cluster of similar genes on chromosome 16. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "Q86YX0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0071276 cellular response to cadmium ion;GO:0071280 cellular response to copper ion;GO:0010273 detoxification of copper ion;GO:0006882 intracellular zinc ion homeostasis;GO:0071294 cellular response to zinc ion",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "P07438-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15439-1",
        "uniprot_id": [
            {
                "id": "MRP4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15439",
                "type": "external"
            }
        ],
        "mass": 149527.0,
        "length": 1325,
        "protein_name": "ATP-binding cassette sub-family C member 4",
        "gene_name": "ABCC4",
        "organism": "Human",
        "refseq_name": "ATP-binding cassette sub-family C member 4 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001098985",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001098985",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ABCC4; MOATB; MRP4",
        "gene_names_refseq": "ABCC4; MOAT-B; MOATB; MRP4",
        "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 4; 7.6.2.-; 7.6.2.2; 7.6.2.3; MOAT-B; MRP/cMOAT-related ABC transporter; Multi-specific organic anion transporter B; Multidrug resistance-associated protein 4",
        "protein_names_refseq": "ATP-binding cassette sub-family C member 4 isoform 2; MRP/cMOAT-related ABC transporter; bA464I2.1 (ATP-binding cassette, sub-family C (CFTR/MRP), member 4); canalicular multispecific organic anion transporter (ABC superfamily); multi-specific organic anion transporter B; multidrug resistance-associated protein 4",
        "tax_id": 9606,
        "disease": "cholestasis (Disease Ontology:DOID:13580); extrahepatic cholestasis (Disease Ontology:DOID:13619); cystic fibrosis (Disease Ontology:DOID:1485); primary ovarian insufficiency (Disease Ontology:DOID:5426)",
        "pathway": " (hsa:10257);  (R-HSA-114608);  (R-HSA-382556);  (R-HSA-9748787);  (R-HSA-9753281)",
        "pathway_count": 5,
        "publication_count": 228,
        "publication_id_list": "10484077;10665657;10741631;10748049;10840050;11106685;11237011;11504826;11562789;11714888;11812794;11856762;12105214;12379217;12379510;12403779;12435799;12473676;12523936;12604685;12697733;12835412;12883481;1352877;1356264;1359686;1377674;1435334;14630798;14661924;15175422;15297306;15364914;15454390;15472518;15747503;15850391;15863492;15899824;16282361;16530731;16696573;16717136;16816140;16901789;17081983;17301077;17344354;17523162;17627974;17855752;17894550;17924658;17959747;17977821;17996297;18232020;18282684;18300232;18357469;18434309;18491316;18669648;18767875;19002207;19447222;19463;19570978;19651622;19664994;1968359;19690332;19691289;197968;19842618;19862647;1998343;20068231;20190787;20216118;20230923;20547088;20583968;20621639;211390;21666065;21712391;21723252;21872626;22178883;22349737;22406294;22411990;22444596;23063411;23096567;23186163;23481700;23640497;23682772;23816837;24019521;24366607;24685677;24714562;24715725;2475911;24824603;24974183;25133187;25418920;25502872;25576301;2570070;2573352;25880248;25892735;26049587;26067475;26154972;26208431;26238318;26721430;26728094;26811146;26992070;27846572;27862975;27920218;28132103;28228285;28467828;28514659;28832583;28834231;28904123;2898143;29242379;29393594;29482072;29493099;29508533;29557506;29769354;30315122;30429286;30484775;30524438;30833945;30987408;31154438;31217245;31222486;31530632;31844290;31848261;32157095;32161166;32350084;32357974;32387766;32472168;32488085;32502341;32897882;32938616;32981041;32983136;33141586;33298915;33592498;33717175;33912179;3395122;33968037;33981976;34087483;34171305;34185709;34357683;34433824;34509645;3457471;3472246;34932366;35051231;35154160;35251023;35494241;35561310;35580925;36010968;36215666;36241641;36284347;37074911;37563361;37683641;37988981;38665916;38886124;40138312;5767308;6457647;657528;6950087;6989049;70646;7469630;7523390;7529176;7553863;7553864;7865904;8226881;8467233;8670112;8813074;9024171;9080;9099726;9132023;9270026;942489;9652413;9661885;9816258;9831708",
        "class_list": "",
        "function": "ABCC4 impacts megakaryopoiesis and protects megakaryocytes against 6-mercaptopurine induced cytotoxicity., [RefSeq, PubMed]; ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells (PubMed:11856762, PubMed:12523936, PubMed:15364914, PubMed:38886124, PubMed:40138312). Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins (PubMed:11856762, PubMed:12523936, PubMed:12835412, PubMed:12883481, PubMed:15364914, PubMed:15454390, PubMed:16282361, PubMed:17959747, PubMed:18300232, PubMed:26721430, PubMed:38886124, PubMed:40138312). Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 (PubMed:17959747). Mediates the cotransport of bile acids with reduced glutathione (GSH) (PubMed:12523936, PubMed:12883481, PubMed:16282361). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotic molecules (PubMed:11856762, PubMed:12105214, PubMed:15454390, PubMed:17344354, PubMed:18300232). Confers resistance to anticancer agents such as methotrexate (PubMed:11106685)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; M6A-modified circABCC4 promotes stemness and metastasis of prostate cancer by recruiting IGF2BP2 to increase stability of CCAR1., [RefSeq, PubMed]; Structural and mechanistic basis of substrate transport by the multidrug transporter MRP4., [RefSeq, PubMed]; The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This family member plays a role in cellular detoxification as a pump for its substrate, organic anions. It may also function in prostaglandin-mediated cAMP signaling in ciliogenesis. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Sep 2014]., [RefSeq]; These findings indicate that a nucleotide transporter, such as MRP4, modulates the cellular response to ganciclovir and thus may influence not only the efficacy of antiviral therapy, but also prodrug-based gene therapy., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A9Z1Z7;B7Z3Q7;Q8IVZ4;Q8IZN6;Q8NEW8;Q9Y6J2",
        "ec_number_list": [
            {
                "id": "7.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2",
                "type": "external"
            },
            {
                "id": "7.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-",
                "type": "external"
            },
            {
                "id": "7.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0046872 metal ion binding;GO:0008559 ABC-type xenobiotic transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane;GO:0031088 platelet dense granule membrane",
        "go_biological_process": "GO:0002576 platelet degranulation;GO:0055085 transmembrane transport;GO:0015721 bile acid and bile salt transport;GO:0006805 xenobiotic metabolic process;GO:0060271 cilium assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 23.7,
        "record_id": "O15439-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43193-1",
        "uniprot_id": [
            {
                "id": "MTLR_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43193",
                "type": "external"
            }
        ],
        "mass": 45344.0,
        "length": 412,
        "protein_name": "Motilin receptor",
        "gene_name": "MLNR",
        "organism": "Human",
        "refseq_name": "motilin receptor",
        "refseq_ac": [
            {
                "id": "NP_001498",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001498",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MLNR; GPR38; MTLR1; MTLR",
        "gene_names_refseq": "GPR38; MLNR; MTLR1",
        "protein_names_uniprotkb": "Motilin receptor; G protein-coupled receptor 38",
        "protein_names_refseq": "G protein-coupled receptor 38; motilin receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2862);  (R-HSA-375276);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 127,
        "publication_id_list": "10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10899166;11015615;11322507;11385580;11457843;11562423;11683476;11742120;11753430;11773063;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15539556;1567413;15947423;15951850;16182515;16268778;16339447;1655761;16754659;16923326;1710450;1710578;1719979;1722333;18127230;18434541;18452278;1847994;18515384;18577758;18936096;1905813;22465164;23142315;23446738;23690594;24906252;2649896;27496565;2841328;3086311;30934667;31154438;3202875;33392160;3366244;33974477;34087483;35051231;3525564;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8440682;8463333;8503909;8615752;8664309;8666380;8702752;873923;8823230;9171878;9305846;9441746;9521323;9530155;9593744;9607765;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "Data support important roles of new regions in the TM domains of the motilin receptor for erythromycin action, suggesting differential mechanisms of actions by peptidyl and non-peptidyl ligands, [RefSeq, PubMed]; Human motilin receptor transgenic (Tg) mice were tested with experiments evaluating the effects of motilin, erythromycin (EM), and ghrelin. Publication Status: Online-Only, [RefSeq, PubMed]; Motilin Receptor Expression Found in the Human Main and Accessory Lacrimal Glands., [RefSeq, PubMed]; Motilin is a 22 amino acid peptide hormone expressed throughout the gastrointestinal (GI) tract. The protein encoded by this gene is a motilin receptor which is a member of the G-protein coupled receptor 1 family. This member is a multi-pass transmembrane protein, and is an important therapeutic target for the treatment of hypomotility disorders. [provided by RefSeq, Aug 2011]., [RefSeq]; Receptor for motilin., [UniProtKB, PubMed]; The data suggested that in species expressing both motilin-MR and ghrelin-GHSR, there is a compensatory relationship in vivo., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042562 hormone binding;GO:0008528 G protein-coupled peptide receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 12.8,
        "record_id": "O43193-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60882-1",
        "uniprot_id": [
            {
                "id": "MMP20_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60882",
                "type": "external"
            }
        ],
        "mass": 54387.0,
        "length": 483,
        "protein_name": "Matrix metalloproteinase-20",
        "gene_name": "MMP20",
        "organism": "Human",
        "refseq_name": "matrix metalloproteinase-20 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_004762",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004762",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MMP20",
        "gene_names_refseq": "AI2A2; MMP-20; MMP20",
        "protein_names_uniprotkb": "Matrix metalloproteinase-20; 3.4.24.-; Enamel metalloproteinase; Enamelysin; MMP-20",
        "protein_names_refseq": "enamel metalloproteinase; matrix metalloproteinase 20 (enamelysin); matrix metalloproteinase-20 preproprotein; matrix metalloproteinase-20",
        "tax_id": 9606,
        "disease": "amelogenesis imperfecta hypomaturation type 2A2 (Disease Ontology:DOID:0110060)",
        "pathway": " (hsa:9313);  (R-HSA-1442490);  (R-HSA-1474228);  (R-HSA-2022090)",
        "pathway_count": 4,
        "publication_count": 110,
        "publication_id_list": "10049780;10229672;10386589;10551873;10596943;10706100;10809722;10922468;10966814;10986281;11013208;11119712;11375993;11577169;11872628;11927537;12482924;12579531;12727852;12843408;1400327;14602708;14973287;15005656;15234972;15257288;15265795;15591058;15744043;15837520;15950618;15958533;16133547;1649600;16631740;16825197;16825321;1698775;1704217;1707285;17088321;17332331;17354228;17608959;17869250;18434311;18622425;18658137;19010778;19571574;19657146;19693541;19714641;2005102;20142769;21030783;21297635;21441952;21593211;21670566;2169335;21784848;21864727;21935455;22159414;22241472;22382088;2253219;23035980;2307289;23481700;23845380;2537292;2548603;2551898;2834383;2845110;29557506;3038863;31838295;3223920;32495503;32777581;33914777;35580925;38253038;39212776;6258630;6270089;6694361;7075587;7547873;7890717;8207089;8226919;8463259;8576151;8626565;8920930;8999957;9008168;9065415;9092507;9115292;9148753;9398237;9461298;9651395;9852107;9856810",
        "class_list": "",
        "function": "AMELX and ODAM variations was not different between two populations of schoolchildren with respect to dental fluorosis (DF) severity; however, the presence of rs1784418 differed between phenotypes with regard to susceptibility to DF. Therefore, MMP20 might be related to the various phenotypes of DF, [RefSeq, PubMed]; Association between LTF/MMP20/CA6/TAS1R2 polymorphisms and susceptibility to dental caries. Publication Status: Online-Only, [RefSeq, PubMed]; Degrades amelogenin, the major protein component of the enamel matrix and two of the macromolecules characterizing the cartilage extracellular matrix: aggrecan and the cartilage oligomeric matrix protein (COMP). May play a central role in tooth enamel formation. Cleaves aggrecan at the '360-Asn-|-Phe-361' site., [UniProtKB, PubMed, PubMed]; Dental malformations associated with biallelic MMP20 mutations., [RefSeq, PubMed]; Lung development, repair and cancer: A study on the role of MMP20 gene in adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. The protein encoded by this gene degrades amelogenin, the major protein component of dental enamel matrix, and thus thought to play a role in tooth enamel formation. A mutation in this gene, which alters the normal splice pattern and results in premature termination of the encoded protein, has been associated with amelogenesis imperfecta. This gene is part of a cluster of MMP genes located on chromosome 11q22.3. [provided by RefSeq, Aug 2011]., [RefSeq]; The possible influence of genetic aetiological factors on molar-incisor hypomineralisation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6DKT9",
        "ec_number_list": [
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "3.4.22.43",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.43",
                "type": "external"
            },
            {
                "id": "3.4.24.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.7",
                "type": "external"
            },
            {
                "id": "3.4.22.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.15",
                "type": "external"
            },
            {
                "id": "3.4.22.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.1",
                "type": "external"
            },
            {
                "id": "3.4.24.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24",
                "type": "external"
            },
            {
                "id": "3.4.24.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.17",
                "type": "external"
            },
            {
                "id": "3.4.24.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.23",
                "type": "external"
            },
            {
                "id": "3.4.24.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.22",
                "type": "external"
            },
            {
                "id": "3.4.24.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.19",
                "type": "external"
            },
            {
                "id": "3.4.24.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35",
                "type": "external"
            },
            {
                "id": "3.4.24.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.34",
                "type": "external"
            },
            {
                "id": "3.4.22.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.27",
                "type": "external"
            },
            {
                "id": "3.4.24.65",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.65",
                "type": "external"
            },
            {
                "id": "3.4.22.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.22.38",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0070173 regulation of enamel mineralization;GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0030574 collagen catabolic process;GO:0097186 amelogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "O60882-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95396-1",
        "uniprot_id": [
            {
                "id": "MOCS3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95396",
                "type": "external"
            }
        ],
        "mass": 49669.0,
        "length": 460,
        "protein_name": "Adenylyltransferase and sulfurtransferase MOCS3",
        "gene_name": "MOCS3",
        "organism": "Human",
        "refseq_name": "adenylyltransferase and sulfurtransferase MOCS3",
        "refseq_ac": [
            {
                "id": "NP_055299",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055299",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MOCS3; UBA4",
        "gene_names_refseq": "MOCODB2; MOCS3; UBA4",
        "protein_names_uniprotkb": "Adenylyltransferase and sulfurtransferase MOCS3; Adenylyltransferase MOCS3; MPT synthase sulfurylase; Molybdenum cofactor synthesis protein 3; Molybdopterin synthase sulfurylase; Sulfur carrier protein MOCS2A adenylyltransferase; Sulfur carrier protein MOCS2A sulfurtransferase; Sulfurtransferase MOCS3",
        "protein_names_refseq": "MPT synthase sulfurylase; UBA4, ubiquitin-activating enzyme E1 homolog; adenylyltransferase and sulfurtransferase MOCS3; molybdenum cofactor synthesis protein 3; molybdopterin synthase sulfurylase; ubiquitin-like modifier activating enzyme 4",
        "tax_id": 9606,
        "disease": "sulfite oxidase deficiency due to molybdenum cofactor deficiency type B2 (MONDO:MONDO:0980701)",
        "pathway": " (hsa:27304);  (R-HSA-947581)",
        "pathway_count": 2,
        "publication_count": 64,
        "publication_id_list": "11302742;12571226;12732628;15073332;15910006;17459099;18650437;19017811;22299025;22453920;23481700;23593335;24715725;25418920;25576301;26154972;26811146;26917578;26992070;27846572;27920218;28218747;28228285;28544736;28832583;28904123;29242379;29393594;29437277;29557506;30315122;30429286;30524438;30817134;30833945;31092671;31154438;31217245;31222486;31530632;31844290;32157095;32161166;32265295;32357974;32387766;32502341;32897882;32901956;32938616;32983136;33141586;33298915;33592498;33897766;33968037;34087483;34171305;34405274;34509645;34932366;35051231;36010968;9990024",
        "class_list": "",
        "function": "Among the associated variants were two in regions previously unreported for COPD; a low frequency non-synonymous SNP in MOCS3 (rs7269297, pdiscovery=3.08x10(-6), preplication=0.019) and a rare SNP in IFIT3, which emerged in the meta-analysis (rs140549288, pmeta=8.56x10(-6))., [RefSeq, PubMed]; By different methods, this study identified a MOCS3-independent novel localization of NFS1 at the centrosome., [RefSeq, PubMed]; Electrospray ionization mass spectrometry performed on a rhodanese-like carboxyl-terminal domain of human MOCS3 provides direct evidence for the formation of persulfide on cysteine residue 412., [RefSeq, PubMed]; In humans & most eukaryotes thiosulfate is not physiologic sulfur donor for MOCS3, whereas in bacterial homologs, which have arginine at last position of active site loop, thiosulfate can be used as a sulfur source for molybdenum cofactor biosynthesis., [RefSeq, PubMed]; MOCS3 protein is believed to catalyze both the adenylation and the subsequent generation of a thiocarboxylate group at the C terminus of the smaller subunit of molybdopterin synthase, [RefSeq, PubMed]; Molecular basis for the bifunctional Uba4-Urm1 sulfur-relay system in tRNA thiolation and ubiquitin-like conjugation., [RefSeq, PubMed]; Molybdenum cofactor (MoCo) is necessary for the function of all molybdoenzymes. The protein encoded by this gene adenylates and activates molybdopterin synthase, an enzyme required for biosynthesis of MoCo. This gene contains no introns. A pseudogene of this gene is present on chromosome 14. [provided by RefSeq, Nov 2012]., [RefSeq]; Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln) (PubMed:19017811, PubMed:22453920, PubMed:30817134). Also essential during biosynthesis of the molybdenum cofactor (PubMed:15073332, PubMed:22453920, PubMed:30817134). Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A (PubMed:15073332, PubMed:19017811, PubMed:22453920). Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus (PubMed:19017811, PubMed:22453920). The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as a nucleophile towards URM1 and MOCS2A (PubMed:15073332, PubMed:22453920). Subsequently, a transient disulfide bond is formed (PubMed:15073332, PubMed:22453920). Does not use thiosulfate as sulfur donor; NFS1 acting as a sulfur donor for thiocarboxylation reactions (PubMed:18650437, PubMed:22453920)., [UniProtKB, PubMed, PubMed, HAMAP, PubMed, PubMed, PubMed]; This observation should encourage testing of additional intellectual disability patients with mild abnormalities of sulfite metabolism for MOCS3 mutations., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "2.7.7.80",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.80",
                "type": "external"
            },
            {
                "id": "2.8.1.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.11",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016783 sulfurtransferase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0016779 nucleotidyltransferase activity;GO:0004792 thiosulfate-cyanide sulfurtransferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0002143 tRNA wobble position uridine thiolation;GO:0034227 tRNA thio-modification;GO:0002098 tRNA wobble uridine modification;GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0032447 protein urmylation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "O95396-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95907-1",
        "uniprot_id": [
            {
                "id": "MOT3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95907",
                "type": "external"
            }
        ],
        "mass": 52319.0,
        "length": 504,
        "protein_name": "Monocarboxylate transporter 3",
        "gene_name": "SLC16A8",
        "organism": "Human",
        "refseq_name": "monocarboxylate transporter 3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_037488",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037488",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC16A8; MCT3",
        "gene_names_refseq": "MCT3; REMP; SLC16A8",
        "protein_names_uniprotkb": "Monocarboxylate transporter 3; MCT 3; Solute carrier family 16 member 8",
        "protein_names_refseq": "MCT 3; monocarboxylate transporter 3 isoform 1; monocarboxylate transporter 3; solute carrier 16 (monocarboxylic acid transporters), member 8; solute carrier family 16 (monocarboxylate transporter), member 8; solute carrier family 16, member 8 (monocarboxylic acid transporter 3)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23539);  (R-HSA-210991);  (R-HSA-433692)",
        "pathway_count": 3,
        "publication_count": 35,
        "publication_id_list": "10493836;10590411;10880960;10921872;11719518;11943775;12558975;12657613;13929721;14707126;15901826;15911216;15917240;15946952;16260747;17701893;17996943;18582575;21199217;24265240;24714562;27966779;28228285;28514659;29331515;29557506;29786170;30315122;33392160;33477551;34211107;35051231;8124722;9360995;9786900",
        "class_list": "",
        "function": "A Splice Variant in SLC16A8 Gene Leads to Lactate Transport Deficit in Human iPS Cell-Derived Retinal Pigment Epithelial Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Probable retinal pigment epithelium (RPE)-specific proton-coupled L-lactate transporter (By similarity). May facilitate transport of lactate and H(+) out of the retina and could therefore play a role in pH and ion homeostasis of the outer retina (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; SLC16A8 is a member of a family of proton-coupled monocarboxylate transporters that mediate lactate transport across cell membranes (Yoon et al., 1999 [PubMed 10493836]).[supplied by OMIM, Apr 2010]., [RefSeq]; The expression level of LIPC, SLC16A8, and TIMP-3 was significantly associated with age-related macular degeneration pathology., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UBE2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0015293 symporter activity;GO:0008028 monocarboxylic acid transmembrane transporter activity;GO:0015129 lactate transmembrane transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016323 basolateral plasma membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0015727 lactate transport",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "O95907-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P10243-1",
        "uniprot_id": [
            {
                "id": "MYBA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P10243",
                "type": "external"
            }
        ],
        "mass": 85887.0,
        "length": 752,
        "protein_name": "Myb-related protein A",
        "gene_name": "MYBL1",
        "organism": "Human",
        "refseq_name": "myb-related protein A isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001073885",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073885",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYBL1; AMYB",
        "gene_names_refseq": "A-MYB; AMYB; MYBL1",
        "protein_names_uniprotkb": "Myb-related protein A; A-Myb; Myb-like protein 1",
        "protein_names_refseq": "myb-like protein 1; myb-related protein A isoform 1; myb-related protein A; v-myb avian myeloblastosis viral oncogene homolog-like 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4603);  (R-HSA-5601884)",
        "pathway_count": 2,
        "publication_count": 45,
        "publication_id_list": "11237011;17531812;18491316;18922463;19608861;21465557;22233380;23056369;23826142;23980886;24656595;25218447;25576301;26992070;27846572;28510447;28514659;28832583;29242379;29508533;29557506;29632046;29786170;30379171;30524438;3060855;31844290;32157095;32488085;32938616;32983136;33592498;33912179;33968037;35051231;35561310;36074655;36591240;38368814;38473786;38797732;39531497;40307207;7987850;8058310",
        "class_list": "",
        "function": "Adenoid cystic carcinoma of the Bartholin's gland is underpinned by MYB- and MYBL1- rearrangements., [RefSeq, PubMed]; Characterization of MYBL1 Gene in Triple-Negative Breast Cancers and the Genes' Relationship to Alterations Identified at the Chromosome 8q Loci. Publication Status: Online-Only, [RefSeq, PubMed]; Downregulation of MYBL1 in endothelial cells contributes to atherosclerosis by repressing PLEKHM1-inducing autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Integration analysis identifies MYBL1 as a novel immunotherapy biomarker affecting the immune microenvironment in clear cell renal cell carcinoma: Evidence based on machine learning and experiments. Publication Status: Online-Only, [RefSeq, PubMed]; Pediatric-type diffuse low-grade glioma with MYB/MYBL1 alteration: report of 2 cases., [RefSeq, PubMed]; Transcription factor that specifically recognizes the sequence 5'-YAAC[GT]G-3' (PubMed:7987850, PubMed:8058310). Acts as a master regulator of male meiosis by promoting expression of piRNAs: activates expression of both piRNA precursor RNAs and expression of protein-coding genes involved in piRNA metabolism (By similarity). The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons, which is essential for the germline integrity (By similarity). Transcriptional activator of SOX30 (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E7EW29;Q495F9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0000278 mitotic cell cycle;GO:0006351 DNA-templated transcription;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "P10243-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q2M385-1",
        "uniprot_id": [
            {
                "id": "MPEG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q2M385",
                "type": "external"
            }
        ],
        "mass": 78587.0,
        "length": 716,
        "protein_name": "Macrophage-expressed gene 1 protein",
        "gene_name": "MPEG1",
        "organism": "Human",
        "refseq_name": "macrophage-expressed gene 1 protein precursor",
        "refseq_ac": [
            {
                "id": "NP_001034485",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034485",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MPEG1",
        "gene_names_refseq": "IMD77; MPEG1; MPG1; MPS-1; MPS1; Mpg-1; P-2; P2",
        "protein_names_uniprotkb": "Macrophage-expressed gene 1 protein; Macrophage gene 1 protein; Mpg-1; P-2; Perforin-2",
        "protein_names_refseq": "macrophage expressed gene 1; macrophage gene 1 protein; macrophage proliferation speci fi c gene-1; macrophage-expressed gene 1 protein precursor; macrophage-expressed gene 1 protein; perforin 2",
        "tax_id": 9606,
        "disease": "primary immunodeficiency disease (Disease Ontology:DOID:612); immunodeficiency 77 (MONDO:MONDO:0030973)",
        "pathway": " (hsa:219972)",
        "pathway_count": 1,
        "publication_count": 53,
        "publication_id_list": "23719902;23753625;24190977;24714562;24798733;26154972;26307549;26402460;26728094;26992070;27397612;27543614;27846572;27862975;28422754;28467828;28705375;28832583;28834231;29242379;29314611;29493099;29557506;29632046;29632711;29769354;29786170;29789417;30429286;30573663;30609079;31154438;31537793;31848261;32350084;32387766;32828820;32983136;33043033;33091337;33123756;33224153;33692780;33717175;33936100;34730110;35051231;35154160;35580925;36284347;37074911;37938771;7888681",
        "class_list": "",
        "function": "Breaching the Bacterial Envelope: The Pivotal Role of Perforin-2 (MPEG1) Within Phagocytes. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Intracellular Staphylococcus aureus triggers pyroptosis and contributes to inhibition of healing due to perforin-2 suppression., [RefSeq, PubMed]; Knockdown of perforin-2 in macrophages did not alter the invasion of host cells but did result in chlamydial growth that closely mirrored that detected in HeLa cells., [RefSeq, PubMed]; Macrophage-specific protein perforin-2 is associated with poor neurological recovery and reduced survival after sudden cardiac arrest., [RefSeq, PubMed]; Pore-forming protein involved in both innate and adaptive immunity (PubMed:23753625, PubMed:26402460, PubMed:28422754, PubMed:30609079, PubMed:31537793, PubMed:33224153). Plays a central role in antigen cross-presentation in dendritic cells by forming a pore in antigen-containing compartments, thereby promoting delivery of antigens for cross-presentation (By similarity). Also involved in innate immune response following bacterial infection; shows antibacterial activity against a wide spectrum of Gram-positive, Gram-negative and acid-fast bacteria (PubMed:23753625, PubMed:26402460, PubMed:28422754, PubMed:30609079, PubMed:33224153). Reduces the viability of the intracytosolic pathogen L.monocytogenes by inhibiting acidification of the phagocytic vacuole of host cells which restricts bacterial translocation from the vacuole to the cytosol (By similarity). Required for the antibacterial activity of reactive oxygen species and nitric oxide (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Pore-forming protein that plays a central role in antigen cross-presentation in dendritic cells by mediating delivery of antigens for cross-presentation (By similarity). Dendritic cells bridge innate and adaptive immunity by capturing exogenous antigens on MHC class-I molecules and presenting them to naive CD8(+) T-cells (By similarity). Acts by forming a pore in antigen-containing compartments, promoting the release of antigens into the cytosol, enabling generation of MHCI:peptide complexes and T-cell priming (By similarity)., [UniProtKB, UniProtKB]; The impact of Perforin-2/macrophage-expressed protein 1 from the earliest multicellular organisms to modern vertebrates, as well as review the development of other membrane attack complexes of complement and Perforin domain member proteins Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 9781,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 2,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2M1T6;Q8TEF8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0022829 wide pore channel activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0031410 cytoplasmic vesicle;GO:0030670 phagocytic vesicle membrane;GO:0045335 phagocytic vesicle;GO:0061474 phagolysosome membrane",
        "go_biological_process": "GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I;GO:0002468 dendritic cell antigen processing and presentation;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "Q2M385-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q2M3A8-1",
        "uniprot_id": [
            {
                "id": "MRAS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q2M3A8",
                "type": "external"
            }
        ],
        "mass": 16456.0,
        "length": 158,
        "protein_name": "Putative uncharacterized protein MRGPRG-AS1",
        "gene_name": "MRGPRG-AS1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "MRGPRG-AS1; C11orf36; HSD-40; HSD40",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative uncharacterized protein MRGPRG-AS1; MRGPRG antisense RNA 1; MRGPRG antisense gene protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6TF48;Q8N7R8;Q8N9X7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "Q2M3A8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q3SYC2-1",
        "uniprot_id": [
            {
                "id": "MOGT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q3SYC2",
                "type": "external"
            }
        ],
        "mass": 38196.0,
        "length": 334,
        "protein_name": "2-acylglycerol O-acyltransferase 2",
        "gene_name": "MOGAT2",
        "organism": "Human",
        "refseq_name": "2-acylglycerol O-acyltransferase 2",
        "refseq_ac": [
            {
                "id": "NP_079374",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079374",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MOGAT2; DC5; DGAT2L5",
        "gene_names_refseq": "DGAT2L5.; DGAT2L5; MGAT2; MOGAT2; hDC5",
        "protein_names_uniprotkb": "2-acylglycerol O-acyltransferase 2; 2.3.1.20; 2.3.1.22; Acyl-CoA:monoacylglycerol acyltransferase 2; Diacylglycerol O-acyltransferase candidate 5; Diacylglycerol acyltransferase 2-like protein 5; MGAT2; Monoacylglycerol O-acyltransferase 2; hDC5; hMGAT2",
        "protein_names_refseq": "2-acylglycerol O-acyltransferase 2; acyl-CoA:monoacylglycerol acyltransferase 2; diacylglycerol O-acyltransferase candidate 5; diacylglycerol acyltransferase 2-like protein 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80168);  (R-HSA-75109)",
        "pathway_count": 2,
        "publication_count": 29,
        "publication_id_list": "11481335;11672446;12576479;12618427;12621063;12824082;14521909;14970677;15845384;16106050;17158099;18238778;18694939;18718904;18768481;19336658;20643956;25418920;25838202;27184406;27531967;27665677;27862975;28420705;29557506;31154438;35580925;36284347;39478862",
        "class_list": "",
        "function": "Diacylglycerol acyltransferase-2 and monoacylglycerol acyltransferase-2 are ubiquitinated proteins that are degraded by the 26S proteasome, [RefSeq, PubMed]; Fatty acid metabolism prognostic signature predicts tumor immune microenvironment and immunotherapy, and identifies tumorigenic role of MOGAT2 in lung adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in glycerolipid synthesis and lipid metabolism (PubMed:12621063, PubMed:18768481, PubMed:27184406, PubMed:28420705). Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol (PubMed:12621063, PubMed:27184406). Plays a central role in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes (By similarity). Has a preference toward monoacylglycerols containing unsaturated fatty acids in an order of C18:3 > C18:2 > C18:1 > C18:0 at sn-2 (PubMed:12621063). Able to use 1-monoalkylglycerol (1-MAkG, 1-O-alkylglycerol) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG, 1-O-alkyl-3-acylglycerol or 1-O-alkyl-2-acylglycerol) and subsequently, with lower efficiency, may add another acyl chain producing monoalkyl-diacylglycerol (MADAG, 1-O-alkyl-2,3-diacylglycerol) (PubMed:28420705). Possesses weak but significant activity with diacylglycerol as substrate, producing triacylglycerol (triacyl-sn-glycerol) (PubMed:18768481)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; MGAT2 is a monoacylglycerol acyltransferase expressed in the small intestine, [RefSeq, PubMed]; MGAT2 may play an important role in dietary fat absorption, [RefSeq, PubMed]; The protein encoded by this gene is an enzyme that catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. The encoded protein is important in the uptake of dietary fat by the small intestine. This protein forms a complex with diacylglycerol O-acyltransferase 2 in the endoplasmic reticulum, and this complex catalyzes the synthesis of triacylglycerol. [provided by RefSeq, Dec 2015]., [RefSeq]; The use of 1-oleoyl-glycerol-d5 and (U13)C-TG oil followed by LC/ESI/MS/MS detection of stable-isotopic labeled DAG, TG, or glycerol provides a wide range of applications to study pathophysiological regulation of the monoacylglycerol pathway and MGAT2 activity., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
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            },
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            },
            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.62",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016407 acetyltransferase activity;GO:0004144 diacylglycerol O-acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane;GO:1990578 perinuclear endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006651 diacylglycerol biosynthetic process;GO:0019432 triglyceride biosynthetic process;GO:0006071 glycerol metabolic process;GO:0006640 monoacylglycerol biosynthetic process",
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    },
    {
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            {
                "id": "MROH9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5TGP6",
                "type": "external"
            }
        ],
        "mass": 65050.0,
        "length": 573,
        "protein_name": "Maestro heat-like repeat-containing protein family member 9",
        "gene_name": "MROH9",
        "organism": "Human",
        "refseq_name": "maestro heat-like repeat-containing protein family member 9 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001157101",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157101",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MROH9; C1orf129",
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        "protein_names_refseq": "armadillo repeat containing 11; maestro heat-like repeat-containing protein family member 9 isoform 1; maestro heat-like repeat-containing protein family member 9",
        "tax_id": 9606,
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        "pathway": " (hsa:80133)",
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    },
    {
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            {
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        "length": 33,
        "protein_name": "Putative makorin-5",
        "gene_name": "MKRN9P",
        "organism": "Human",
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        "refseq_ac": [],
        "gene_names_uniprotkb": "MKRN9P; MKRN5; MKRN9; MKRNP6; RNF65; ZNF127L3",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative makorin-5; Makorin ring finger protein pseudogene 6; Makorin ring finger protein pseudogene 9; Putative RING finger protein 65",
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    },
    {
        "uniprot_canonical_ac": "Q86VD1-1",
        "uniprot_id": [
            {
                "id": "MORC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86VD1",
                "type": "external"
            }
        ],
        "mass": 112881.0,
        "length": 984,
        "protein_name": "MORC family CW-type zinc finger protein 1",
        "gene_name": "MORC1",
        "organism": "Human",
        "refseq_name": "MORC family CW-type zinc finger protein 1",
        "refseq_ac": [
            {
                "id": "NP_055244",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055244",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MORC1; MORC",
        "gene_names_refseq": "CT33; MORC1; MORC; ZCW6",
        "protein_names_uniprotkb": "MORC family CW-type zinc finger protein 1; CT33; Cancer/testis antigen 33",
        "protein_names_refseq": "MORC family CW-type zinc finger protein 1; cancer/testis antigen 33; microrchidia, mouse, homolog of",
        "tax_id": 9606,
        "disease": "melancholic depression (Disease Ontology:DOID:1595)",
        "pathway": " (hsa:27136)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "10369865;23481700;24715725;25158004;25576301;29890506;30315122;30377343;30379171;31683097;31844290;32502341;33401128;35051231",
        "class_list": "",
        "function": "Investigation of MORC1 DNA methylation as biomarker of early life stress and depressive symptoms., [RefSeq, PubMed]; MORC1 is thus the first identified epigenetic marker of ELS to be present in blood cell progenitors at birth and in the brain in adulthood. Publication Status: Online-Only, [RefSeq, PubMed]; MORC1 methylation and BDI are associated with microstructural features of the hippocampus and medial prefrontal cortex., [RefSeq, PubMed]; Required for spermatogenesis (By similarity). Essential for de novo DNA methylation and silencing of transposable elements in the male embryonic germ cells (By similarity)., [UniProtKB, UniProtKB]; The results of this study showed that DNA methylation in the MORC1 promoter region significantly correlates with the Beck Depression Inventory score in the examined non-clinical population., [RefSeq, PubMed]; This gene encodes the human homolog of mouse morc and like the mouse protein it is testis-specific. Mouse studies support a testis-specific function since only male knockout mice are infertile; infertility is the only apparent defect. These studies further support a role for this protein early in spermatogenesis, possibly by affecting entry into apoptosis because testis from knockout mice show greatly increased numbers of apoptotic cells. [provided by RefSeq, Jan 2009]., [RefSeq]",
        "predicted_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "secondary_ac_list": "B4DYX1;E7ERX1;Q7L8E2;Q9NSG7;Q9Y6D4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0031047 regulatory ncRNA-mediated gene silencing",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q86VD1-1",
        "record_type": "protein",
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    },
    {
        "uniprot_canonical_ac": "Q86VF5-1",
        "uniprot_id": [
            {
                "id": "MOGT3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86VF5",
                "type": "external"
            }
        ],
        "mass": 38730.0,
        "length": 341,
        "protein_name": "2-acylglycerol O-acyltransferase 3",
        "gene_name": "MOGAT3",
        "organism": "Human",
        "refseq_name": "2-acylglycerol O-acyltransferase 3 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001274076",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001274076",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MOGAT3; DC7; DGAT2L7; PRO34208",
        "gene_names_refseq": "DC7; DGAT2L2; MGAT3; MOGAT3",
        "protein_names_uniprotkb": "2-acylglycerol O-acyltransferase 3; 2.3.1.20; 2.3.1.22; Acyl-CoA:monoacylglycerol acyltransferase 3; Diacylglycerol O-acyltransferase candidate 7; Diacylglycerol acyltransferase 2-like protein 7; MGAT3; Monoacylglycerol O-acyltransferase 3; hDC7",
        "protein_names_refseq": "2-acylglycerol O-acyltransferase 3 isoform b; 2-acylglycerol O-acyltransferase 3; acyl coenzyme A:monoacylglycerol acyltransferase 3; acyl-CoA:monoacylglycerol acyltransferase 3; diacylglycerol O-acyltransferase candidate 7; diacylglycerol acyltransferase 2-like protein 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:346606);  (R-HSA-75109)",
        "pathway_count": 2,
        "publication_count": 21,
        "publication_id_list": "11481335;11672446;12618427;12824082;12975309;14521909;14970677;15845384;16214399;17158099;18238778;18694939;18718904;18768481;19336658;20643956;25838202;27184406;28420705;35580925;38253038",
        "class_list": "",
        "function": "Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA (Cheng et al., 2003 [PubMed 12618427]).[supplied by OMIM, Mar 2008]., [RefSeq]; Catalyzes the formation of diacylglycerol from 2-monoacylglycerol and fatty acyl-CoA. Also able to catalyze the terminal step in triacylglycerol synthesis by using diacylglycerol and fatty acyl-CoA as substrates. Has a preference toward palmitoyl-CoA and oleoyl-CoA. May be involved in absorption of dietary fat in the small intestine by catalyzing the resynthesis of triacylglycerol in enterocytes. Also able to use 1-monoalkylglycerol (1-MAkG) as an acyl acceptor for the synthesis of monoalkyl-monoacylglycerol (MAMAG) (PubMed:28420705)., [UniProtKB, PubMed, PubMed, PubMed]; MGAT3 encodes a approximately 36-kDa transmembrane protein that is highly homologous to MGAT1 and -2 and is expressed in the human gastrointestinal tract with the highest level found in the ileum, [RefSeq, PubMed]",
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        "secondary_ac_list": "Q496A6;Q496A7;Q496A8;Q9UDW7",
        "ec_number_list": [
            {
                "id": "2.3.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20",
                "type": "external"
            },
            {
                "id": "2.3.1.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76",
                "type": "external"
            },
            {
                "id": "3.1.1.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.4",
                "type": "external"
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            {
                "id": "3.1.1.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.1.3",
                "type": "external"
            },
            {
                "id": "2.3.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.22",
                "type": "external"
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            {
                "id": "2.3.1.75",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.75",
                "type": "external"
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            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.62",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.62",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:1990578 perinuclear endoplasmic reticulum membrane",
        "go_biological_process": "GO:0019432 triglyceride biosynthetic process;GO:0006071 glycerol metabolic process;GO:0006640 monoacylglycerol biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q86VF5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N119-1",
        "uniprot_id": [
            {
                "id": "MMP21_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N119",
                "type": "external"
            }
        ],
        "mass": 65043.0,
        "length": 569,
        "protein_name": "Matrix metalloproteinase-21",
        "gene_name": "MMP21",
        "organism": "Human",
        "refseq_name": "matrix metalloproteinase-21 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_671724",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_671724",
                "type": "external"
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        ],
        "gene_names_uniprotkb": "MMP21",
        "gene_names_refseq": "HTX7; MMP-21; MMP21",
        "protein_names_uniprotkb": "Matrix metalloproteinase-21; 3.4.24.-; MMP-21",
        "protein_names_refseq": "matrix metalloproteinase 21; matrix metalloproteinase-21 preproprotein",
        "tax_id": 9606,
        "disease": "visceral heterotaxy (Disease Ontology:DOID:0050545); visceral heterotaxy 7 (Disease Ontology:DOID:0051021)",
        "pathway": " (hsa:118856)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;12490321;12617721;15015597;26429889;26437028;26437029;29575199;31016793;31582779;36123719",
        "class_list": "",
        "function": "A novel miRNA-4484 is up-regulated on microarray and associated with increased MMP-21 expression in serum of systemic sclerosis patients. Publication Status: Online-Only, [RefSeq, PubMed]; Data show that MMP21 (encoding matrix metallopeptidase 21) point mutations were verified by Sanger sequencing, and segregation analysis indicated recessive inheritance., [RefSeq, PubMed]; De novo disruptive heterozygous MMP21 variants are potential predisposing genetic risk factors in Chinese Han heterotaxy children. Publication Status: Online-Only, [RefSeq, PubMed]; MMP-21 572TT genotype increased the risk for the HIV-associated neurocognitive disorder., [RefSeq, PubMed]; Plays a specialized role in the generation of left-right asymmetry during embryogenesis. May act as a negative regulator of the NOTCH-signaling pathway (PubMed:26429889, PubMed:26437028). Cleaves alpha-1-antitrypsin (PubMed:12617721)., [UniProtKB, PubMed, PubMed, PubMed]; TWIST1, MMP-21, and HLAG-1 co-overexpression is associated with ESCC aggressiveness., [RefSeq, PubMed]; The MMP-21 gene 572C/T polymorphism has no significant effect on the development and progression of breast cancer. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a member of the matrix metalloproteinase family. Proteins in this family are involved in the breakdown of extracellular matrix for both normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, and disease processes, such as asthma and tumor metastasis. The encoded protein may play an important role in embryogenesis, particularly in neuronal cells, as well as in lymphocyte development and survival. [provided by RefSeq, May 2013]., [RefSeq]",
        "predicted_glycosites": 2,
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        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VZP9;Q8NG02",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004222 metalloendopeptidase activity;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0006508 proteolysis;GO:0030198 extracellular matrix organization;GO:0007368 determination of left/right symmetry;GO:0030574 collagen catabolic process;GO:0061371 determination of heart left/right asymmetry",
        "synthesized_glycan_count": 0,
        "hit_score": 1.2,
        "record_id": "Q8N119-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NDA8-1",
        "uniprot_id": [
            {
                "id": "MROH1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NDA8",
                "type": "external"
            }
        ],
        "mass": 181249.0,
        "length": 1641,
        "protein_name": "Maestro heat-like repeat-containing protein family member 1",
        "gene_name": "MROH1",
        "organism": "Human",
        "refseq_name": "maestro heat-like repeat-containing protein family member 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001092750",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092750",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MROH1; HEATR7A; KIAA1833",
        "gene_names_refseq": "HEATR7A; MROH1",
        "protein_names_uniprotkb": "Maestro heat-like repeat-containing protein family member 1; HEAT repeat-containing protein 7A",
        "protein_names_refseq": "HEAT repeat containing 7A; HEAT repeat-containing protein 7A; maestro heat-like repeat-containing protein family member 1 isoform 2; maestro heat-like repeat-containing protein family member 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:727957)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "11237011;17924679;23481700;24715725;25418920;25505266;25576301;25645385;25892735;26811146;26992070;27920218;28218747;28228285;28446606;28514659;28832583;28904123;29242379;29437277;29493099;29508533;29557506;29769354;29786170;30379171;30410026;30524438;31217245;31844290;32157095;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33537174;33912179;33968037;34185709;34357683;35051231;36010968;36215666;36581221;37938771;38538795",
        "class_list": "",
        "function": "Lysosome fission factor (PubMed:38538795). Recruited to lysosomes by RAB7 (RAB7A or RAB7B) at scission sites and homooligomerizes to mediate the constriction and scission of lysosomal tubules (PubMed:38538795). May sever membranes by inserting amphipathic helices into one bilayer leaflet (PubMed:38538795). Lysosome fission is required to maintain their steady-state number, shape, size, composition and function, and to accomplish regeneration (PubMed:38538795)., [UniProtKB, PubMed]; The HEAT repeat protein HPO-27 is a lysosome fission factor., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JWM5;D3DWL5;Q0P612;Q569G6;Q6NVW4;Q8N230;Q8NAD1;Q8ND95;Q96JJ4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0140912 membrane destabilizing activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005765 lysosomal membrane",
        "go_biological_process": "GO:0170064 lysosome fission",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q8NDA8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96EN8-1",
        "uniprot_id": [
            {
                "id": "MOCOS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96EN8",
                "type": "external"
            }
        ],
        "mass": 98120.0,
        "length": 888,
        "protein_name": "Molybdenum cofactor sulfurase",
        "gene_name": "MOCOS",
        "organism": "Human",
        "refseq_name": "molybdenum cofactor sulfurase",
        "refseq_ac": [
            {
                "id": "NP_060417",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060417",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MOCOS",
        "gene_names_refseq": "HMCS; MCS; MOCOS; MOS",
        "protein_names_uniprotkb": "Molybdenum cofactor sulfurase; 2.8.1.9; MCS; MOS; MoCo sulfurase; Molybdenum cofactor sulfurtransferase; hMCS",
        "protein_names_refseq": "human molybdenum cofactor sulfurase; molybdenum cofactor sulfurase",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); obstructive nephropathy (Disease Ontology:DOID:0070314); xanthinuria type II (Disease Ontology:DOID:0070453)",
        "pathway": " (hsa:55034);  (R-HSA-947581)",
        "pathway_count": 2,
        "publication_count": 46,
        "publication_id_list": "11302742;12571226;12732628;14624414;16115862;16964243;16973608;17322306;17368066;18650437;18669648;18767875;19615748;20058876;20068231;23186163;24275569;25576301;28510447;29557506;29935280;30429286;30484775;31844290;31900757;32157095;32327736;32488085;32938616;33537174;33592498;33968037;33981976;34087483;34171305;34185709;34356852;34932366;35051231;35318648;35580925;36010968;36215666;36241641;36284347;9990024",
        "class_list": "",
        "function": "Impaired expression of the COSMOC/MOCOS gene unit in ASD patient stem cells., [RefSeq, PubMed]; Sulfurates the molybdenum cofactor (PubMed:34356852). Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form (PubMed:34356852). In vitro, the C-terminal domain is able to reduce N-hydroxylated prodrugs, such as benzamidoxime (PubMed:16973608)., [UniProtKB, HAMAP, PubMed, PubMed]; The rs594445 in MOCOS gene is associated with risk of autism spectrum disorder., [RefSeq, PubMed]; This gene encodes an enzyme that sulfurates the molybdenum cofactor which is required for activation of the xanthine dehydrogenase (XDH) and aldehyde oxidase (AO) enzymes. XDH catalyzes the conversion of hypoxanthine to uric acid via xanthine, as well as the conversion of allopurinol to oxypurinol, and pyrazinamide to 5-hydroxy pyrazinamide. Mutations in this gene cause the metabolic disorder classical xanthinuria type II which is characterized by the loss of XDH/XO and AO enzyme activity, decreased levels of uric acid in the urine, increased levels of xanthine and hypoxanthine in the serum and urine, formation of xanthine stones in the urinary tract, and myositis due to tissue deposition of xanthine. [provided by RefSeq, Apr 2017]., [RefSeq]; Two mutations, both in the N-terminal domain of the Human Molybdenum Cofactor Sulfurase (HMCS), were reported in patients with type II xanthinuria., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53GP5;Q8N3A4;Q9NWM7",
        "ec_number_list": [
            {
                "id": "2.8.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.8.1.9",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0030151 molybdenum ion binding;GO:0030170 pyridoxal phosphate binding;GO:0016829 lyase activity;GO:0008265 molybdenum cofactor sulfurtransferase activity",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0006777 Mo-molybdopterin cofactor biosynthetic process;GO:0032324 molybdopterin cofactor biosynthetic process;GO:0043545 molybdopterin cofactor metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q96EN8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96PD6-1",
        "uniprot_id": [
            {
                "id": "MOGT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96PD6",
                "type": "external"
            }
        ],
        "mass": 38812.0,
        "length": 335,
        "protein_name": "2-acylglycerol O-acyltransferase 1",
        "gene_name": "MOGAT1",
        "organism": "Human",
        "refseq_name": "2-acylglycerol O-acyltransferase 1",
        "refseq_ac": [
            {
                "id": "NP_477513",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_477513",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MOGAT1; DC2; DGAT2L1",
        "gene_names_refseq": "DGAT2L1; DGAT2L; MGAT1; MOGAT1",
        "protein_names_uniprotkb": "2-acylglycerol O-acyltransferase 1; 2.3.1.22; Acyl-CoA:monoacylglycerol acyltransferase 1; Diacylglycerol O-acyltransferase candidate 2; Diacylglycerol acyltransferase 2-like protein 1; MGAT1; Monoacylglycerol O-acyltransferase 1; hDC2",
        "protein_names_refseq": "2-acylglycerol O-acyltransferase 1; acyl-CoA:monoacylglycerol acyltransferase 1; diacylglycerol O-acyltransferase 2 like 1; diacylglycerol O-acyltransferase candidate 2; diacylglycerol acyltransferase 2-like protein 1; hDC2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:116255);  (R-HSA-75109)",
        "pathway_count": 2,
        "publication_count": 15,
        "publication_id_list": "11481335;11672446;12618427;12621063;12824082;14521909;14970677;15845384;17158099;18238778;18694939;18718904;19336658;20643956;25838202",
        "class_list": "",
        "function": "Acyl-CoA:monoacylglycerol acyltransferase (MOGAT; EC 2.3.1.22) catalyzes the synthesis of diacylglycerols, the precursor of physiologically important lipids such as triacylglycerol and phospholipids (Yen et al., 2002 [PubMed 12077311]).[supplied by OMIM, Mar 2008]., [RefSeq]; Involved in glycerolipid synthesis and lipid metabolism. Catalyzes the formation of diacylglycerol, the precursor of triacylglycerol, by transferring the acyl chain of a fatty acyl-CoA to a monoacylglycerol, mainly at the sn-1 or sn-3 positions. It uses both sn-2-monoacylglycerol (2-acylglycerol) and sn-1-monoacylglycerol (1-acyl-sn-glycerol) equally well as substrates, and uses sn-3-monoacylglycerol (3-acyl-sn-glycerol) with lower efficiency. Probably not involved in absorption of dietary fat in the small intestine., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IEE5",
        "ec_number_list": [
            {
                "id": "2.3.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.20",
                "type": "external"
            },
            {
                "id": "2.3.1.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.76",
                "type": "external"
            },
            {
                "id": "2.3.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.22",
                "type": "external"
            },
            {
                "id": "2.3.1.75",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.75",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.62",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.62",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004144 diacylglycerol O-acyltransferase activity;GO:0003846 2-acylglycerol O-acyltransferase activity",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0006651 diacylglycerol biosynthetic process;GO:0019432 triglyceride biosynthetic process;GO:0006071 glycerol metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q96PD6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86XR7-1",
        "uniprot_id": [
            {
                "id": "TCAM2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86XR7",
                "type": "external"
            }
        ],
        "mass": 26916.0,
        "length": 235,
        "protein_name": "TIR domain-containing adapter molecule 2",
        "gene_name": "TICAM2",
        "organism": "Human",
        "refseq_name": "TRAM adaptor with GOLD domain isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001157940",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157940",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TICAM2; TIRAP3; TIRP; TRAM",
        "gene_names_refseq": "TMED7-TICAM2",
        "protein_names_uniprotkb": "TIR domain-containing adapter molecule 2; MyD88-4; Putative NF-kappa-B-activating protein 502; TICAM-2; TRIF-related adapter molecule; Toll-like receptor adaptor protein 3; Toll/interleukin-1 receptor domain-containing protein",
        "protein_names_refseq": "TMED7-TICAM2 read-through transcript; TRAM adaptor with GOLD domain isoform 1 precursor",
        "tax_id": 9606,
        "disease": "Coronavirus infectious disease (Disease Ontology:DOID:0080599)",
        "pathway": " (hsa:100302736);  (hsa:353376);  (R-HSA-140534);  (R-HSA-166016);  (R-HSA-166166);  (R-HSA-2562578);  (R-HSA-6798695);  (R-HSA-936964);  (R-HSA-937041);  (R-HSA-937072);  (R-HSA-975163);  (R-HSA-9824878)",
        "pathway_count": 12,
        "publication_count": 88,
        "publication_id_list": "10201950;10702308;10882101;11057907;11274165;12181749;12242293;12471095;12609980;12620240;12692549;12721283;12752666;12761501;12855817;14517278;14519765;14556004;14703513;14739303;15210742;15276183;15327770;15596121;15814722;16115877;16186825;16260493;16303959;16306936;16306937;16467847;16547522;16603398;16603631;16751103;16757566;16964262;17047224;17135271;17157040;17496917;17526488;17599067;17823124;17878161;18222170;18233961;18297073;18810425;19278658;19412184;19656901;19675569;19898473;20047764;20308068;21737329;21737330;21862579;21931591;22078883;22123964;22158869;22685567;23453969;23453971;23453972;23650620;2462607;2477488;25385819;25825441;27538435;28411811;29786170;30883606;31530632;32502341;32938616;32983136;33592498;33717175;3537192;8692836;9566918;9665271;9744859",
        "class_list": "",
        "function": "Functions as a sorting adapter in different signaling pathways to facilitate downstream signaling leading to type I interferon induction (PubMed:16603631, PubMed:16757566, PubMed:25385819, PubMed:25825441). In TLR4 signaling, physically bridges TLR4 and TICAM1 and functionally transmits signal to TICAM1 in early endosomes after endocytosis of TLR4. In TLR2 signaling, physically bridges TLR2 and MYD88 and is required for the TLR2-dependent movement of MYD88 to endosomes following ligand engagement (PubMed:25385819). Involved in IL-18 signaling and is proposed to function as a sorting adapter for MYD88 in IL-18 signaling during adaptive immune response (PubMed:22685567). Forms a complex with RAB11FIP2 that is recruited to the phagosomes to promote the activation of the actin-regulatory GTPases RAC1 and CDC42 and subsequent phagocytosis of Gram-negative bacteria (PubMed:30883606)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Proposed to inhibit LPS-TLR4 signaling at the late endosome by interaction with isoform 1 thereby disrupting the association of isoform 1 with TICAM1. May be involved in TLR4 degradation in late endosomes., [UniProtKB]; This locus represents naturally occurring read-through transcription between the neighboring transmembrane emp24 protein transport domain containing 7 (TMED7) and toll-like receptor adaptor molecule 2 (TICAM2) genes. Alternative splicing results in multiple transcript variants, one of which encodes a fusion protein that shares sequence identity with the products of each individual gene. This fusion product functions to negatively regulate the adaptor MyD88-independent toll-like receptor 4 pathway. [provided by RefSeq, Nov 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
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        "total_s_glycosites": 0,
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        "reported_phosphosites": 3,
        "reported_mutagensis": 10,
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        "missing_score": 0,
        "biomarker_type": "",
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        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3Y698;Q6JUT2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0035591 signaling adaptor activity",
        "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005768 endosome;GO:0005769 early endosome;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0035669 TRAM-dependent toll-like receptor 4 signaling pathway;GO:0006954 inflammatory response;GO:0045087 innate immune response;GO:0006909 phagocytosis;GO:0071222 cellular response to lipopolysaccharide",
        "synthesized_glycan_count": 0,
        "hit_score": 9.1,
        "record_id": "Q86XR7-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NV12-1",
        "uniprot_id": [
            {
                "id": "TM140_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NV12",
                "type": "external"
            }
        ],
        "mass": 20419.0,
        "length": 185,
        "protein_name": "Transmembrane protein 140",
        "gene_name": "TMEM140",
        "organism": "Human",
        "refseq_name": "transmembrane protein 140",
        "refseq_ac": [
            {
                "id": "NP_060765",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060765",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TMEM140",
        "gene_names_refseq": "TMEM140",
        "protein_names_uniprotkb": "Transmembrane protein 140",
        "protein_names_refseq": "transmembrane protein 140",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55281)",
        "pathway_count": 1,
        "publication_count": 29,
        "publication_id_list": "16959974;25036476;25645385;26154972;26198430;26375851;27862975;27920218;28063628;28467828;28514659;28904123;29242379;29557506;29632711;29769354;29786170;30573663;31154438;31844290;31848261;32488085;32502341;32938616;32983136;33968037;34357683;34561969;35051231",
        "class_list": "",
        "function": "Binding of viral UL31 to host TMEM140 impedes formation of HSV-1 UL31-UL34 complex., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
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        "glyco_site_count": 1,
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        "secondary_ac_list": "A4D1P9;Q8WUC3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q9NV12-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96HA7-1",
        "uniprot_id": [
            {
                "id": "TONSL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96HA7",
                "type": "external"
            }
        ],
        "mass": 150929.0,
        "length": 1378,
        "protein_name": "Tonsoku-like protein",
        "gene_name": "TONSL",
        "organism": "Human",
        "refseq_name": "tonsoku-like protein",
        "refseq_ac": [
            {
                "id": "NP_038460",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038460",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TONSL; IKBR; NFKBIL2",
        "gene_names_refseq": "IKBR; NFKBIL2; SEMDSP; TONSL",
        "protein_names_uniprotkb": "Tonsoku-like protein; I-kappa-B-related protein; IkappaBR; Inhibitor of kappa B-related protein; NF-kappa-B inhibitor-like protein 2; Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2",
        "protein_names_refseq": "I-kappa-B-related protein; NF-kappa-B inhibitor-like protein 2; ikappaBR; inhibitor of kappa B-related protein; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 2; tonsoku-like protein",
        "tax_id": 9606,
        "disease": "spondyloepimetaphyseal dysplasia, Sponastrime type (Disease Ontology:DOID:5684)",
        "pathway": " (hsa:4796)",
        "pathway_count": 1,
        "publication_count": 87,
        "publication_id_list": "11246458;18691976;20068231;20485444;21055983;21055984;21055985;21113133;23186163;23481700;24714562;24715725;25418920;25576301;25645385;25880248;25892735;26154972;26375851;26527279;26728094;26992070;27338793;27797818;27846572;27920218;28832583;28834231;28904123;29242379;29478807;29508533;29557506;29632046;29632711;29769354;30315122;30379171;30429286;30484775;30620550;30773277;30773278;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32938750;32959051;32983136;33141586;33298915;33592498;33633747;33691108;33717175;33912179;33936100;33968037;34087483;34171305;34185709;34211107;34405274;34509645;34932366;35051231;35254053;35561310;35580925;36010968;36241641;36581221;36622344;37057595;37217939;37298484;37340703;40307207;7738005;9242696",
        "class_list": "",
        "function": "Component of the MMS22L-TONSL complex, a complex that promotes homologous recombination-mediated repair of double-strand breaks (DSBs) at stalled or collapsed replication forks (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:21113133, PubMed:26527279, PubMed:27338793, PubMed:27797818, PubMed:29478807, PubMed:30773278). The MMS22L-TONSL complex is required to maintain genome integrity during DNA replication (PubMed:21055983, PubMed:21055984, PubMed:21055985). It mediates the assembly of RAD51 filaments on single-stranded DNA (ssDNA): the MMS22L-TONSL complex is recruited to DSBs following histone replacement by histone chaperones and eviction of the replication protein A complex (RPA/RP-A) from DSBs (PubMed:21055983, PubMed:21055984, PubMed:21055985, PubMed:27797818, PubMed:29478807). Following recruitment to DSBs, the TONSL-MMS22L complex promotes recruitment of RAD51 filaments and subsequent homologous recombination (PubMed:27797818, PubMed:29478807). Within the complex, TONSL acts as a histone reader, which recognizes and binds newly synthesized histones following their replacement by histone chaperones (PubMed:27338793, PubMed:29478807). Specifically binds histone H4 lacking methylation at 'Lys-20' (H4K20me0) and histone H3.1 (PubMed:27338793)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MMS22L and TONSL are required for the maintenance of genome stability., [RefSeq, PubMed]; MMS22L-TONSL functions in sister chromatid cohesion in a pathway parallel to DSCC1-RFC. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Oncogenic Impact of TONSL, a Homologous Recombination Repair Protein at the Replication Fork, in Cancer Stem Cells. Publication Status: Online-Only, [RefSeq, PubMed]; TONSL Is an Immortalizing Oncogene and a Therapeutic Target in Breast Cancer., [RefSeq, PubMed]; The protein encoded by this gene is thought to be a negative regulator of NF-kappa-B mediated transcription. The encoded protein may bind NF-kappa-B complexes and trap them in the cytoplasm, preventing them from entering the nucleus and interacting with the DNA. Phosphorylation of this protein targets it for degradation by the ubiquitination pathway, which frees the NF-kappa-B complexes to enter the nucleus. [provided by RefSeq, Jul 2008]., [RefSeq]; These results indicate that MMS22L and TONSL are genome caretakers that stimulate the recombination-dependent repair of stalled or collapsed replication forks., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 6,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 6,
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        "reported_snv": 38,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B5MDP0;C9JKB1;C9JNV8;Q13006;Q9UGJ2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042393 histone binding;GO:0140566 histone reader activity",
        "go_cellular_component": "GO:0043596 nuclear replication fork;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016604 nuclear body;GO:0035861 site of double-strand break",
        "go_biological_process": "GO:0000724 double-strand break repair via homologous recombination;GO:0031297 replication fork processing;GO:0071168 protein localization to chromatin",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q96HA7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P62328-1",
        "uniprot_id": [
            {
                "id": "TYB4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P62328",
                "type": "external"
            }
        ],
        "mass": 5053.0,
        "length": 44,
        "protein_name": "Thymosin beta-4",
        "gene_name": "TMSB4X",
        "organism": "Human",
        "refseq_name": "thymosin beta-4",
        "refseq_ac": [
            {
                "id": "NP_066932",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066932",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TMSB4X; TB4X; THYB4; TMSB4",
        "gene_names_refseq": "FX; PTMB4; TB4X; TMSB4X; TMSB4",
        "protein_names_uniprotkb": "Thymosin beta-4; Ac-Ser-Asp-Lys-Pro; AcSDKP; Fx; N-acetyl-SDKP; Seraspenide; T beta-4",
        "protein_names_refseq": "prothymosin beta-4; t beta-4; thymosin beta-4; thymosin, beta 4, X chromosome",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7114);  (R-HSA-114608)",
        "pathway_count": 2,
        "publication_count": 95,
        "publication_id_list": "10848969;1435334;14630798;15297306;16010977;18077418;18446792;18991276;19608861;1999398;20068231;21406692;22223895;22299025;23009842;23186163;23640497;23783831;24029068;24366607;24715725;25505266;25576301;25892735;25946035;26154972;26992070;27452731;27846572;27920218;28218747;28446606;28832583;29242379;29314611;29317506;29393594;29493099;29508533;29557506;29632711;29786170;30315122;30429286;30524438;30833945;31217245;31222486;31530632;31611695;31844290;31848261;32157095;32161166;32350084;32357974;32488085;32897882;32938616;32983136;33141586;33298915;33592498;33912179;33968037;33981976;34019948;34087483;34171305;34211107;34357683;34433824;34561969;34932366;3500230;35051231;35154160;35318648;35561310;35580925;36215666;36241641;36284347;36321670;36424462;37175390;38049080;38409346;39894887;6457647;6548414;7694679;7876104;8257427;8467233",
        "class_list": "",
        "function": "Aberrant Expression of Thymosin Beta-4 Correlates With Advanced Disease and BRAF V600E Mutation in Thyroid Cancer., [RefSeq, PubMed]; In Vitro Study of Thymosin Beta 4 Promoting Transplanted Fat Survival by Regulating Adipose-Derived Stem Cells., [RefSeq, PubMed]; Nuclear factor (erythroid-derived 2)-like 2 counter-regulates thymosin beta-4 expression and primary cilium formation for HeLa cervical cancer cell survival. Publication Status: Online-Only, [RefSeq, PubMed]; Plays an important role in the organization of the cytoskeleton (PubMed:10848969, PubMed:1999398). Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (PubMed:10848969, PubMed:1999398)., [UniProtKB, PubMed, PubMed]; Potent inhibitor of bone marrow derived stem cell differentiation (PubMed:7694679). Acts by inhibits the entry of hematopoietic pluripotent stem cells into the S-phase (By similarity)., [UniProtKB, UniProtKB, PubMed]; The Pathophysiological Role of Thymosin beta4 in the Kidney Glomerulus. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an actin sequestering protein which plays a role in regulation of actin polymerization. The protein is also involved in cell proliferation, migration, and differentiation. This gene escapes X inactivation and has a homolog on chromosome Y. [provided by RefSeq, Jul 2008]., [RefSeq]; Upregulated Tbeta4 expression in inflammatory bowel disease impairs the intestinal mucus barrier by inhibiting autophagy in mice., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "reported_phosphosites": 4,
        "reported_mutagensis": 5,
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        "missing_score": 0,
        "biomarker_type": "",
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        "glyco_site_count": 0,
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        "secondary_ac_list": "P01253;P01254;Q546P5;Q63576;Q9UE55",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003785 actin monomer binding;GO:0019899 enzyme binding;GO:0140311 protein sequestering activity;GO:0003788 actin monomer sequestering activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:2001171 positive regulation of ATP biosynthetic process;GO:2001028 positive regulation of endothelial cell chemotaxis;GO:0007015 actin filament organization;GO:0050728 negative regulation of inflammatory response;GO:0043124 negative regulation of canonical NF-kappaB signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 9.8,
        "record_id": "P62328-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N7F7-1",
        "uniprot_id": [
            {
                "id": "UBL4B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N7F7",
                "type": "external"
            }
        ],
        "mass": 19909.0,
        "length": 174,
        "protein_name": "Ubiquitin-like protein 4B",
        "gene_name": "UBL4B",
        "organism": "Human",
        "refseq_name": "ubiquitin-like protein 4B",
        "refseq_ac": [
            {
                "id": "NP_981957",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_981957",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UBL4B",
        "gene_names_refseq": "UBL4B",
        "protein_names_uniprotkb": "Ubiquitin-like protein 4B",
        "protein_names_refseq": "ubiquitin-like protein 4B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:164153)",
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        "publication_count": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:1903955 positive regulation of protein targeting to mitochondrion",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "Q8N7F7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000001.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q93015-1",
        "uniprot_id": [
            {
                "id": "NAA80_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q93015",
                "type": "external"
            }
        ],
        "mass": 31445.0,
        "length": 286,
        "protein_name": "N-alpha-acetyltransferase 80",
        "gene_name": "NAA80",
        "organism": "Human",
        "refseq_name": "N-alpha-acetyltransferase 80 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001186947",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186947",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAA80; FUS2; NAT6",
        "gene_names_refseq": "ANDS; FUS-2; FUS2; HsNAAA80; NAA80; NAT6",
        "protein_names_uniprotkb": "N-alpha-acetyltransferase 80; 2.3.1.-; HsNAAA80; N-acetyltransferase 6; Protein fus-2; Protein fusion-2",
        "protein_names_refseq": "N-acetyltransferase 6 (GCN5-related); N-alpha-acetyltransferase 80 isoform 2; protein fusion-2",
        "tax_id": 9606,
        "disease": "auroneurodental syndrome (MONDO:MONDO:0970998)",
        "pathway": " (hsa:24142)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "10.1101/2023.09.13.557529;10644992;11085536;11237011;11929860;15036368;29581253;29581307;30028079;30315122;31092671;31844290;31848261;32161166;32978259;34805998;34896361;38189249",
        "class_list": "",
        "function": "Characterization of the murine hyaluronidase gene region reveals complex organization and cotranscription of Hyal1 with downstream genes, Fus2 and Hyal3., [RefSeq, PubMed]; N-alpha-acetyltransferase that specifically mediates the acetylation of the acidic amino terminus of processed forms of beta- and gamma-actin (ACTB and ACTG, respectively) (PubMed:29581253, PubMed:30028079). N-terminal acetylation of processed beta- and gamma-actin regulates actin filament depolymerization and elongation (PubMed:29581253). In vivo, preferentially displays N-terminal acetyltransferase activity towards acid N-terminal sequences starting with Asp-Asp-Asp and Glu-Glu-Glu (PubMed:29581253, PubMed:30028079). In vitro, shows high activity towards Met-Asp-Glu-Leu and Met-Asp-Asp-Asp (PubMed:10644992, PubMed:29581307). May act as a tumor suppressor (PubMed:10644992)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; N-terminal acetyltransferase 6 facilitates enterovirus 71 replication by regulating PI4KB expression and replication organelle biogenesis., [RefSeq, PubMed]; Newly identified polymorphism leads to a non-conservative amino acid change (R222W) located between the acetyltransferase and the proline-rich domains; analysis suggests no likely association between nasopharyngeal cancer and the FUS2 gene polymorphism GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; PFN2 and NAA80 cooperate to efficiently acetylate the N-terminus of actin., [RefSeq, PubMed]; The Final Maturation State of beta-actin Involves N-terminal Acetylation by NAA80, not N-terminal Arginylation by ATE1., [RefSeq, PubMed]; The results demonstrate NAA80's role as actin's NAT and reveal a crucial role for actin Nt-acetylation in the control of cytoskeleton structure and dynamics. GeneRIF: NAT6/FUS-2 is the N-alpha acetyltransferase 80 (NAA80/NatH) acting post-translationally and specifically on processed animal actins. This NAA80 mediated actin N-terminal acetylation is crucial for actin polymerization and depolymerization, and regulates the actin cytoskeleton and cell motility., [RefSeq, PubMed]; This gene encodes a member of the N-acetyltransferase family. N-acetyltransferases modify proteins by transferring acetyl groups from acetyl CoA to the N-termini of protein substrates. The encoded protein is a cytoplasmic N-acetyltransferase with a substrate specificity for proteins with an N-terminal methionine. This gene is located in the tumor suppressor gene region on chromosome 3p21.3 and the encoded protein may play a role in cancer. Alternatively spliced transcript variants encoding multiple isoforms have been observed. This gene overlaps and is on the same strand as hyaluronoglucosaminidase 3, and some transcripts of each gene share a portion of the first exon. [provided by RefSeq, Jan 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 9718,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q93014",
        "ec_number_list": [
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008080 N-acetyltransferase activity;GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:1905502 acetyl-CoA binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0008064 regulation of actin polymerization or depolymerization;GO:0006473 protein acetylation;GO:0030047 actin modification;GO:0018002 N-terminal peptidyl-glutamic acid acetylation;GO:0017190 N-terminal peptidyl-aspartic acid acetylation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q93015-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UKN7-1",
        "uniprot_id": [
            {
                "id": "MYO15_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UKN7",
                "type": "external"
            }
        ],
        "mass": 395293.0,
        "length": 3530,
        "protein_name": "Unconventional myosin-XV",
        "gene_name": "MYO15A",
        "organism": "Human",
        "refseq_name": "unconventional myosin-XV",
        "refseq_ac": [
            {
                "id": "NP_057323",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057323",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO15A; MYO15",
        "gene_names_refseq": "DFNB3; MYO15A; MYO15",
        "protein_names_uniprotkb": "Unconventional myosin-XV; Unconventional myosin-15",
        "protein_names_refseq": "myosin-XV; unconventional myosin-15; unconventional myosin-XV",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness 3 (Disease Ontology:DOID:0110488); sensorineural hearing loss (Disease Ontology:DOID:10003); blindness (Disease Ontology:DOID:1432)",
        "pathway": " (hsa:51168);  (R-HSA-9662360);  (R-HSA-9662361)",
        "pathway_count": 3,
        "publication_count": 47,
        "publication_id_list": "10025409;10552926;10821263;11163272;11237011;11735029;19807924;20068231;23481700;24715725;24926664;25418920;25645385;25892735;26929215;28228285;28832583;29242379;29557506;29632046;29769354;30315122;30410026;31844290;32157095;32357974;32387766;32488085;32938616;33298915;33592498;33717175;33968037;34087483;34171305;35051231;35346193;35494241;36010968;36150242;36217262;37189200;37217939;38167320;39531497;39620501;9603736",
        "class_list": "",
        "function": "Analysis of the genotype-phenotype correlation of MYO15A variants in Chinese non-syndromic hearing loss patients. Publication Status: Online-Only, [RefSeq, PubMed]; Exosomal microRNA-1 and MYO15A as a target for therapy and diagnosis in renal cell carcinoma., [RefSeq, PubMed]; Identification of novel compound heterozygous mutations of the MYO15A gene with autosomal recessive non-syndromic hearing loss., [RefSeq, PubMed]; Loss-of-function mutations in MYO15A and OTOF cause non-syndromic hearing loss in two Yemeni families. Publication Status: Online-Only, [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Required for the arrangement of stereocilia in mature hair bundles (By similarity)., [UniProtKB]; Novel compound heterozygous MYO15A splicing variants in autosomal recessive non-syndromic hearing loss. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 81,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DFC7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003779 actin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0015629 actin cytoskeleton;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0032420 stereocilium",
        "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0007605 sensory perception of sound;GO:0009416 response to light stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q9UKN7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.001000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WUY8-1",
        "uniprot_id": [
            {
                "id": "NAT14_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WUY8",
                "type": "external"
            }
        ],
        "mass": 21650.0,
        "length": 206,
        "protein_name": "Probable N-acetyltransferase 14",
        "gene_name": "NAT14",
        "organism": "Human",
        "refseq_name": "probable N-acetyltransferase 14",
        "refseq_ac": [
            {
                "id": "NP_065111",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065111",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAT14; KLP1",
        "gene_names_refseq": "KLP1; NAT14",
        "protein_names_uniprotkb": "Probable N-acetyltransferase 14; 2.3.1.-; K562 cell-derived leucine-zipper-like protein 1",
        "protein_names_refseq": "K562 cell-derived leucine-zipper-like protein 1; K562 cells-derived leucine-zipper-like protein 1; N-acetyltransferase 14 (GCN5-related, putative); probable N-acetyltransferase 14",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57106)",
        "pathway_count": 1,
        "publication_count": 20,
        "publication_id_list": "10873651;11237011;11779635;19807691;23481700;26154972;27846572;27920218;28411811;28904123;31844290;32157095;32161166;32488085;32938616;33141586;33968037;34171305;35051231;36010968",
        "class_list": "",
        "function": "May act as a transcription factor that regulates the expression of coproporphyrinogen oxidase by binding to a promoter regulatory element., [UniProtKB, PubMed]; Probable acetyltransferase., [UniProtKB, UniProtKB, UniProtKB]; Results indicated that NAT8L, but not NAT14, catalysed the synthesis of NAA from L-aspartate and acetyl-CoA. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8TDY7;Q9NS72",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008080 N-acetyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0016020 membrane",
        "go_biological_process": "GO:0045893 positive regulation of DNA-templated transcription;GO:0006352 DNA-templated transcription initiation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "Q8WUY8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UHC9-1",
        "uniprot_id": [
            {
                "id": "NPCL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UHC9",
                "type": "external"
            }
        ],
        "mass": 148728.0,
        "length": 1359,
        "protein_name": "NPC1-like intracellular cholesterol transporter 1",
        "gene_name": "NPC1L1",
        "organism": "Human",
        "refseq_name": "NPC1-like intracellular cholesterol transporter 1 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001095118",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001095118",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NPC1L1",
        "gene_names_refseq": "LDLCQ7; NPC11L1; NPC1L1; SLC65A2",
        "protein_names_uniprotkb": "NPC1-like intracellular cholesterol transporter 1; NPC1L1; Niemann-Pick C1-like protein 1",
        "protein_names_refseq": "NPC1 (Niemann-Pick disease, type C1, gene)-like 1; NPC1 like 1; NPC1-like intracellular cholesterol transporter 1 isoform 2 precursor; niemann-Pick C1-like protein 1",
        "tax_id": 9606,
        "disease": "Niemann-Pick disease type C1 (Disease Ontology:DOID:0070113); Niemann-Pick disease (Disease Ontology:DOID:14504)",
        "pathway": " (hsa:29881)",
        "pathway_count": 1,
        "publication_count": 37,
        "publication_id_list": "10783261;11237011;14976318;15604518;15671032;15679830;15928087;19325169;19542231;21525977;22095670;23481700;25390462;27893789;28467828;28904123;29557506;29769354;29880681;30078552;30484775;31844290;32350084;32488085;33141586;33592498;33912179;33968037;34087483;34185709;35580925;36583755;37217939;37355634;38233830;38280151;38713618",
        "class_list": "",
        "function": "Association of NPC1L1 and HMGCR gene polymorphisms with coronary artery calcification in patients with premature triple-vessel coronary disease. Publication Status: Online-Only, [RefSeq, PubMed]; Cholesterol uptake in the intestine is regulated by the LASP1-AKT-NPC1L1 signaling pathway., [RefSeq, PubMed]; Expression is enriched in the small intestine and is in the brush border membrane of enterocytes, [RefSeq, PubMed]; HMGCR gene polymorphism is associated with residual cholesterol risk in premature triple-vessel disease patients treated with moderate-intensity statins. Publication Status: Online-Only, [RefSeq, PubMed]; M6A-related bioinformatics analysis and functional characterization reveals that METTL3-mediated NPC1L1 mRNA hypermethylation facilitates progression of atherosclerosis via inactivation of the MAPK pathway., [RefSeq, PubMed]; NPC1L1 has a role in lipid transport and in diet-induced hypercholesterolemia, [RefSeq, PubMed]; NPC1L1 rs217434 A > G as a Novel Single Nucleotide Polymorphism Related to Dyslipidemia in a Korean Population., [RefSeq, PubMed]; Plays a major role in cholesterol homeostasis (PubMed:22095670). Critical for the uptake of cholesterol across the plasma membrane of the intestinal enterocyte (PubMed:22095670). Involved in plant sterol absorption, it transports sitosterol, although at lower rates than cholesterol (By similarity). Is the direct molecular target of ezetimibe, a drug that inhibits cholesterol absorption and is approved for the treatment of hypercholesterolemia (PubMed:15928087). May have a function in the transport of multiple lipids and their homeostasis, thereby influencing lipid metabolism regulation (PubMed:15671032). May be involved in caveolin trafficking from the plasma membrane (By similarity). In addition, acts as a negative regulator of NPC2 and down-regulates its expression and secretion by inhibiting its maturation and accelerating its degradation (PubMed:22095670)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, UniProtKB]; The protein encoded by this gene is a multi-pass membrane protein. It contains a conserved N-terminal Niemann-Pick C1 (NPC1) domain and a putative sterol-sensing domain (SSD) which includes a YQRL motif functioning as a plasma membrane to trans-Golgi network transport signal in other proteins. This protein takes up free cholesterol into cells through vesicular endocytosis and plays a critical role in the absorption of intestinal cholesterol. It also has the ability to transport alpha-tocopherol (vitamin E). The drug ezetimibe targets this protein and inhibits the absorption of intestinal cholesterol and alpha-tocopherol. In addition, this protein may play a critical role in regulating lipid metabolism. Polymorphic variations in this gene are associated with plasma total cholesterol and low-density lipoprotein cholesterol (LDL-C) levels and coronary heart disease (CHD) risk. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 9,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 9,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 9,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 76,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D2J7;B7ZLE6;D3DVK9;Q17RV5;Q6R3Q4;Q9UHC8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0015485 cholesterol binding;GO:0031267 small GTPase binding;GO:0008431 vitamin E binding;GO:0031489 myosin V binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016324 apical plasma membrane;GO:0030659 cytoplasmic vesicle membrane;GO:0012505 endomembrane system;GO:0031526 brush border membrane",
        "go_biological_process": "GO:0071501 cellular response to sterol depletion;GO:0042157 lipoprotein metabolic process;GO:0006695 cholesterol biosynthetic process;GO:0030299 intestinal cholesterol absorption;GO:0042632 cholesterol homeostasis",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q9UHC9-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NJU9-1",
        "uniprot_id": [
            {
                "id": "NPB13_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NJU9",
                "type": "external"
            }
        ],
        "mass": 125964.0,
        "length": 1138,
        "protein_name": "Nuclear pore complex-interacting protein family member B13",
        "gene_name": "NPIPB12; NPIPB13; NPIPB4; NPIPB5",
        "organism": "Human",
        "refseq_name": "nuclear pore complex-interacting protein family member B13",
        "refseq_ac": [
            {
                "id": "NP_001308821",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308821",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NPIPB12; NPIPB13; NPIPB4; NPIPB5; NPIPB12; NPIPB13; NPIPB4; NPIPB5",
        "gene_names_refseq": "NPIPB13",
        "protein_names_uniprotkb": "Nuclear pore complex-interacting protein family member B13",
        "protein_names_refseq": "Putative NPIP-like protein LOC613037; nuclear pore complex interacting protein member; nuclear pore complex-interacting protein family member B13",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:440345);  (hsa:613037)",
        "pathway_count": 2,
        "publication_count": 5,
        "publication_id_list": "11237011;24715725;27600516;32357974;32387766",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.6,
        "record_id": "A6NJU9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13952-1",
        "uniprot_id": [
            {
                "id": "NFYC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13952",
                "type": "external"
            }
        ],
        "mass": 50302.0,
        "length": 458,
        "protein_name": "Nuclear transcription factor Y subunit gamma",
        "gene_name": "NFYC",
        "organism": "Human",
        "refseq_name": "nuclear transcription factor Y subunit gamma isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001136059",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136059",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NFYC",
        "gene_names_refseq": "CBF-C; CBFC; H1TF2A; HAP5; HSM; NF-YC; NFYC",
        "protein_names_uniprotkb": "Nuclear transcription factor Y subunit gamma; CAAT box DNA-binding protein subunit C; NF-YC; Nuclear transcription factor Y subunit C; Transactivator HSM-1/2",
        "protein_names_refseq": "CAAT box DNA-binding protein subunit C; CCAAT binding factor subunit C; CCAAT transcription binding factor subunit gamma; histone H1 transcription factor large subunit 2A; nuclear transcription factor Y subunit C; nuclear transcription factor Y subunit gamma isoform 3; nuclear transcription factor Y, gamma; transactivator HSM-1/2; transactivator HSM-1; transcription factor NF-Y, C subunit",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4802);  (R-HSA-1989781);  (R-HSA-2426168);  (R-HSA-380994);  (R-HSA-381183);  (R-HSA-9614657)",
        "pathway_count": 6,
        "publication_count": 184,
        "publication_id_list": "10102273;10400691;10446203;10759542;10777541;10958673;11237011;11267664;11414710;11777915;12083769;12118000;12177166;12401788;12505311;12582161;12764144;1377680;14576824;14701673;14742429;14973138;15067378;15130092;15385533;15509806;15635043;16380219;16687408;16912112;16931790;16943287;16959974;16972786;16989641;17449569;17925399;18158893;18285520;18540824;18559965;18654640;18682402;18719978;18726356;18840095;18848529;19088433;1968462;19710929;19934321;20022965;20110263;20138239;20361218;20450493;20719759;20937905;20978166;22412893;22634312;22802018;22819556;22898188;22978410;23269699;23332751;23481700;23707940;2377606;24196956;24714562;24715725;25576301;25645385;26154972;2663993;2664463;26715362;26728094;26758079;26992070;27543614;27561725;27600516;27920218;28228285;28649982;28832583;28904123;29242379;29351928;29393594;29413899;29493099;29508533;29533771;29557506;29632046;30059200;30192525;30410026;30524438;30779550;30833945;30845926;31154438;31222486;31492838;31530632;31844290;31998317;32119511;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32574038;3260265;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34405274;34509645;34846842;34932366;35051231;35132862;35138101;35254053;35289036;35580925;35705054;36010968;36215666;36241641;36580660;38665916;39531497;40307207;40596516;40914422;7567999;7592729;7685352;7732023;7892212;7909540;8020941;8619637;8626466;8626488;8647822;8663599;8798690;8910521;8976377;9012850;9099716;9249075;9332362;9604010;9634533;9748239;9748295;9837962",
        "class_list": "",
        "function": "Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The genes FABP7 and NFYC(-AS1) could play a role in airflow obstruction in never-smokers specifically. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes one subunit of a trimeric complex forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoters of a variety of genes. The encoded protein, subunit C, forms a tight dimer with the B subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
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        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DUS6;B4DW63;D3DPV9;F8VWM3;Q59GY4;Q5T6K8;Q5T6K9;Q5T6L1;Q5TZR6;Q92869;Q9HBX1;Q9NXB5;Q9UM67;Q9UML0;Q9UMT7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0046982 protein heterodimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0032993 protein-DNA complex;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0006457 protein folding",
        "synthesized_glycan_count": 0,
        "hit_score": 19.3,
        "record_id": "Q13952-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14896-1",
        "uniprot_id": [
            {
                "id": "MYPC3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14896",
                "type": "external"
            }
        ],
        "mass": 140762.0,
        "length": 1274,
        "protein_name": "Myosin-binding protein C, cardiac-type",
        "gene_name": "MYBPC3",
        "organism": "Human",
        "refseq_name": "myosin-binding protein C, cardiac-type",
        "refseq_ac": [
            {
                "id": "NP_000247",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000247",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYBPC3",
        "gene_names_refseq": "CMD1MM; CMH4; FHC; LVNC10; MYBP-C; MYBPC3; cMyBP-C",
        "protein_names_uniprotkb": "Myosin-binding protein C, cardiac-type; C-protein, cardiac muscle isoform; Cardiac MyBP-C",
        "protein_names_refseq": "myosin binding protein C, cardiac; myosin-binding protein C, cardiac-type",
        "tax_id": 9606,
        "disease": "familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); dilated cardiomyopathy 1MM (Disease Ontology:DOID:0081158); hypertrophic cardiomyopathy 4 (Disease Ontology:DOID:0110310); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); congenital heart disease (Disease Ontology:DOID:1682)",
        "pathway": " (hsa:4607);  (R-HSA-390522)",
        "pathway_count": 2,
        "publication_count": 59,
        "publication_id_list": "10521296;10747208;11237011;11499718;11499719;11815426;12110947;12379228;12628722;12707239;12787675;12818575;12951062;12974739;14563344;15114369;15213454;15519027;15563892;15582318;16004897;16199542;17075052;17322306;18374358;18403758;18560154;18926831;18929575;18957093;20018870;20151718;20215591;21551322;23271734;23840593;26163040;26960196;28265379;29557506;30379171;31154438;31848261;31998317;33936100;35051231;35254053;35580925;38253038;38258577;38387507;38456273;38877002;7493026;7744002;9048664;9541104;9541115;9562578",
        "class_list": "",
        "function": "A Promoter Deletion Confirms That MYBPC3 Haploinsufficiency Is Sufficient to Cause Hypertrophic Cardiomyopathy in Humans., [RefSeq, PubMed]; Cardiac myosin binding protein-C phosphorylation as a function of multiple protein kinase and phosphatase activities. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic Testing Yield and Clinical Characteristics of Hypertrophic Cardiomyopathy in Understudied Ethnic Groups: Insights From a New Zealand National Registry., [RefSeq, PubMed]; MYBPC3 encodes the cardiac isoform of myosin-binding protein C. Myosin-binding protein C is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. MYBPC3 is expressed exclusively in heart muscle and is a key regulator of cardiac contraction. Mutations in this gene are a frequent cause of familial hypertrophic cardiomyopathy. [provided by RefSeq, May 2022]., [RefSeq]; Missense variants in phospholamban and cardiac myosin binding protein identified in patients with a family history and clinical diagnosis of dilated cardiomyopathy. Review article, [RefSeq, PubMed]; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role., [UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
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        "biomarker_type": "",
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        "secondary_ac_list": "A5PL00;Q16410;Q6R2F7;Q9UE27;Q9UM53",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0017022 myosin binding;GO:0008307 structural constituent of muscle",
        "go_cellular_component": "GO:0005829 cytosol;GO:0030017 sarcomere;GO:0031430 M band;GO:0031672 A band;GO:0097512 cardiac myofibril",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0003007 heart morphogenesis;GO:0060048 cardiac muscle contraction;GO:0045214 sarcomere organization;GO:0086004 regulation of cardiac muscle cell contraction",
        "synthesized_glycan_count": 0,
        "hit_score": 6.4,
        "record_id": "Q14896-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14764-1",
        "uniprot_id": [
            {
                "id": "MVP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14764",
                "type": "external"
            }
        ],
        "mass": 99327.0,
        "length": 893,
        "protein_name": "Major vault protein",
        "gene_name": "MVP",
        "organism": "Human",
        "refseq_name": "major vault protein isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001280133",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280133",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MVP; LRP",
        "gene_names_refseq": "LRP; MVP; VAULT1",
        "protein_names_uniprotkb": "Major vault protein; Lung resistance-related protein; MVP",
        "protein_names_refseq": "lung resistance-related protein; major vault protein isoform 2; testicular secretory protein Li 30",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9961);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 102,
        "publication_id_list": "10551828;11071864;11237011;11297743;12177006;15133037;16373071;16418217;16441665;16815308;18083107;18452278;18669648;18809583;20068231;20166139;22223895;23481700;23650620;23719902;24275569;24714562;24715725;25502872;25576301;25755297;25892735;26154972;26375851;26728094;26992070;27397612;27452731;27846572;27862975;28228285;28467828;28649982;28832583;28834231;28895081;28904123;29242379;29314611;29393594;29437277;29493099;29508533;29557506;29786170;30315122;30397120;30429286;31092671;31154438;31217245;31222486;31844290;31848261;32157095;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33043033;33123756;33141586;33298915;33392160;33592498;33633747;33717175;33912179;33936100;33968037;34171305;34357683;34433824;34509645;34561969;34725712;34829999;34932366;35051231;35154160;35318648;35561310;35580925;36215666;36241641;36284347;37217939;37938771;38264642;38665916;38713157;40691181;7585126;8692836",
        "class_list": "",
        "function": "MVP Expression Facilitates Tumor Cell Proliferation and Migration Supporting the Metastasis of Colorectal Cancer Cells. Publication Status: Online-Only, [RefSeq, PubMed]; MVP gene expression regulated by alternative splicing due to generation of an upstream open reading frame, [RefSeq, PubMed]; Major vault protein regulates tumor-associated macrophage polarization through interaction with signal transducer and activator of transcription 6. Publication Status: Online-Only, [RefSeq, PubMed]; Structural component of the vault particle, which is a massive ribonucleoprotein complex that may play a role in cargo transport and signal transduction (PubMed:40691181). Oligomerizes to form a cage-like vault complex, which can house several minor vault components including PARP4 (PubMed:40691181). Vaults may play a role in nucleo-cytoplasmic transport (PubMed:15133037). Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK (PubMed:16418217). Down-regulates SRC activity and signaling through MAP kinases (PubMed:16441665)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The prognostic value and immunological role of MVP in pan-cancer study., [RefSeq, PubMed]; This gene encodes the major component of the vault complex. Vaults are multi-subunit ribonucleoprotein structures that may be involved in nucleo-cytoplasmic transport. The encoded protein may play a role in multiple cellular processes by regulating the MAP kinase, JAK/STAT and phosphoinositide 3-kinase/Akt signaling pathways. The encoded protein also plays a role in multidrug resistance, and expression of this gene may be a prognostic marker for several types of cancer. Alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, May 2012]., [RefSeq]",
        "predicted_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "reported_snv": 12,
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        "missing_score": 0,
        "biomarker_type": "",
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        "secondary_ac_list": "Q96BG4;Q9BPW6;Q9BQT1;Q9UBD1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0042802 identical protein binding;GO:0019903 protein phosphatase binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005643 nuclear pore;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0072376 protein activation cascade;GO:0038127 ERBB signaling pathway;GO:0008283 cell population proliferation;GO:0015031 protein transport;GO:0035556 intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "Q14764-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86TP1-1",
        "uniprot_id": [
            {
                "id": "PRUN1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86TP1",
                "type": "external"
            }
        ],
        "mass": 50200.0,
        "length": 453,
        "protein_name": "Exopolyphosphatase PRUNE1",
        "gene_name": "PRUNE1",
        "organism": "Human",
        "refseq_name": "exopolyphosphatase PRUNE1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001290158",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001290158",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PRUNE1; PRUNE",
        "gene_names_refseq": "DRES-17; DRES17; H-PRUNE; HTCD37; NMIHBA; PRUNE1; PRUNE",
        "protein_names_uniprotkb": "Exopolyphosphatase PRUNE1; 3.6.1.14; 3.6.1.25; DRES-17; DRES17; Drosophila-related expressed sequence 17; HTcD37; Protein prune homolog 1; hPrune",
        "protein_names_refseq": "Drosophila-related expressed sequence 17; exopolyphosphatase PRUNE1 isoform 2; exopolyphosphatase PRUNE1; protein prune homolog 1",
        "tax_id": 9606,
        "disease": "neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies (MONDO:MONDO:0060490)",
        "pathway": " (hsa:58497)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "10524757;10602478;11237011;11687967;14998490;15671547;16428445;17655525;17906697;18077418;18700747;23301498;25576301;26154972;26539891;26992070;27846572;27920218;28211990;28334956;28832583;29242379;29393594;29557506;29786170;30484775;30524438;32157095;32357974;32387766;32897882;32938616;32983136;33105479;33298915;33592498;33968037;34111303;34932366;35051231;35318648;35379233;35561310;35580925;36010968;36241641;37316325;37666675;37938771",
        "class_list": "",
        "function": "An identical-by-descent novel splice-donor variant in PRUNE1 causes a neurodevelopmental syndrome with prominent dystonia in two consanguineous Sudanese families., [RefSeq, PubMed]; Exopolyphosphatase that catalyzes the hydrolysis of inorganic polyphosphates, with preference for short-chain substrates, as well as nucleoside 5'-tetraphosphates, releasing terminal phosphate residues (PubMed:18700747). Also exhibits phosphodiesterase activity toward cyclic nucleotides, hydrolyzing cAMP and cGMP to their corresponding 5'-monophosphates (PubMed:14998490, PubMed:17655525). Requires divalent metal ions for activity (PubMed:14998490, PubMed:18700747). Plays a role in cell proliferation, migration and differentiation, and acts as a negative regulator of NME1 (PubMed:10602478, PubMed:11687967, PubMed:14998490, PubMed:16428445, PubMed:17906697). Plays a role in the regulation of neurogenesis. Involved in the regulation of microtubule polymerization (PubMed:28334956)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; GSK-3 and h-prune cooperatively regulate the disassembly of focal adhesions to promote cell migration and that h-prune is useful as a marker for tumor aggressiveness., [RefSeq, PubMed]; NMIHBA results from hypomorphic PRUNE1 variants that lack short-chain exopolyphosphatase activity., [RefSeq, PubMed]; Neurodevelopmental disorder with microcephaly, hypotonia, and variable brain anomalies in a consanguineous Iranian family is associated with a homozygous start loss variant in the PRUNE1 gene. Publication Status: Online-Only, [RefSeq, PubMed]; PRUNE1 (located on chromosome 1q21.3) promotes multiple myeloma with 1q21 Gain by enhancing the links between purine and mitochondrion., [RefSeq, PubMed]; Prune has a role in breast neoplasm aggressiveness Erratum:[Clin Cancer Res. 2005 Feb 1;11(3):1353], [RefSeq, PubMed]; Prune is composed of two independent active sites and two interaction sites for the assembly of oligomeric signalling complexes, [RefSeq, PubMed]; This gene encodes a member of the DHH protein superfamily of phosphoesterases. This protein has been found to function as both a nucleotide phosphodiesterase and an exopolyphosphatase. This protein is believed to stimulate cancer progression and metastases through the induction of cell motility. A pseuodgene has been identified on chromosome 13. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2014]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCH8;B4DFL7;Q5SZF9;Q659E5;Q6P4E0;Q8N654;Q96JU5;Q9C071;Q9C072;Q9UIV0",
        "ec_number_list": [
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.1.4.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17",
                "type": "external"
            },
            {
                "id": "3.1.4.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53",
                "type": "external"
            },
            {
                "id": "3.1.4.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35",
                "type": "external"
            },
            {
                "id": "3.1.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1",
                "type": "external"
            },
            {
                "id": "3.6.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9",
                "type": "external"
            },
            {
                "id": "3.6.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25",
                "type": "external"
            },
            {
                "id": "3.6.1.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0015631 tubulin binding;GO:0004427 inorganic diphosphate phosphatase activity;GO:0016791 phosphatase activity;GO:0004309 exopolyphosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005925 focal adhesion",
        "go_biological_process": "GO:0031113 regulation of microtubule polymerization;GO:0050767 regulation of neurogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q86TP1-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N9H8-1",
        "uniprot_id": [
            {
                "id": "MUT7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N9H8",
                "type": "external"
            }
        ],
        "mass": 96598.0,
        "length": 876,
        "protein_name": "Exonuclease mut-7 homolog",
        "gene_name": "EXD3",
        "organism": "Human",
        "refseq_name": "exonuclease mut-7 homolog isoform b",
        "refseq_ac": [
            {
                "id": "NP_001273752",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273752",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EXD3; HBE269",
        "gene_names_refseq": "EXD3; Nbr; mut-7",
        "protein_names_uniprotkb": "Exonuclease mut-7 homolog; 3.1.-.-; Exonuclease 3'-5' domain-containing protein 3",
        "protein_names_refseq": "exonuclease 3'-5' domain-containing protein 3; exonuclease mut-7 homolog isoform b; exonuclease mut-7 homolog; nibbler homolog; testicular tissue protein Li 125",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54932)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;23481700;24715725;25576301;25880248;28228285;28832583;29242379;29557506;30429286;30890511;31844290;32357974;33141586;33592498;33968037;33981976;35051231;36241641;37217939;39894887",
        "class_list": "",
        "function": "EXD3 may be a potential oncogene in gastric cancer possibly in relation to DNA damage repair. The up-regulation of EXD3 plays an important role in the development and prognosis of gastric cancer, and may serve as an important indicator for prognostic evaluation of the patients., [RefSeq, PubMed]; Possesses 3'-5' exoribonuclease activity. Required for 3'-end trimming of AGO1-bound miRNAs (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_n_glycosites": 0,
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        "reported_phosphosites": 0,
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        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A140VJP9;B8A4U7;C9JIQ9;E9PN82;Q2TAK4;Q6P1M1;Q8IXT8;Q8N3X4;Q8NHD1;Q96NP1;Q9NX53",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0003676 nucleic acid binding;GO:0008408 3'-5' exonuclease activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0006139 nucleobase-containing compound metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q8N9H8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9P2K5-1",
        "uniprot_id": [
            {
                "id": "MYEF2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9P2K5",
                "type": "external"
            }
        ],
        "mass": 64122.0,
        "length": 600,
        "protein_name": "Myelin expression factor 2",
        "gene_name": "MYEF2",
        "organism": "Human",
        "refseq_name": "myelin expression factor 2 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001288139",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001288139",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYEF2; KIAA1341",
        "gene_names_refseq": "HsT18564; MEF-2; MST156; MSTP156; MYEF2; myEF-2",
        "protein_names_uniprotkb": "Myelin expression factor 2; MEF-2; MST156; MyEF-2",
        "protein_names_refseq": "myelin expression factor 2 isoform b; myelin gene expression factor 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:50804)",
        "pathway_count": 1,
        "publication_count": 56,
        "publication_id_list": "11237011;17287340;18510355;18707149;19664995;20709755;21406692;22424782;22544926;23481700;24275569;24715725;25418920;25645385;25892735;26154972;26811146;27866970;27871913;27920218;28218747;28228285;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29786170;30315122;30410026;30833945;31154438;31217245;31530632;31611695;31844290;31848261;32157095;32357974;32387766;32938616;33298915;33968037;33981976;34019948;34211107;34509645;35051231;35561310;36658471;39894887",
        "class_list": "",
        "function": "Both polymorphisms (rs1426654 and rs2470102) play an important role in the skin pigmentation diversity of South Asians, [RefSeq, PubMed]; Expression and function of myelin expression factor 2 in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein Muscleblind-like 3 (MBNL3) disrupts myocyte enhancer factor 2 (Mef2) {beta}-exon splicing, [RefSeq, PubMed]; This study demonstrated that none of the associations between time-frequency phenotypes and MYEF2 were significant., [RefSeq, PubMed]; Transcriptional repressor of the myelin basic protein gene (MBP). Binds to the proximal MB1 element 5'-TTGTCC-3' of the MBP promoter. Its binding to MB1 and function are inhibited by PURA (By similarity)., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7MCZ9;C9J921;C9K0J4;Q6NUM5;Q7L388;Q7Z4B7;Q9H922;Q9NUQ1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0030182 neuron differentiation;GO:0014902 myotube differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "Q9P2K5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96NY8-1",
        "uniprot_id": [
            {
                "id": "NECT4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96NY8",
                "type": "external"
            }
        ],
        "mass": 55454.0,
        "length": 510,
        "protein_name": "Nectin-4",
        "gene_name": "NECTIN4",
        "organism": "Human",
        "refseq_name": "nectin-4 precursor",
        "refseq_ac": [
            {
                "id": "NP_112178",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_112178",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NECTIN4; LNIR; PRR4; PVRL4",
        "gene_names_refseq": "EDSS1; LNIR; NECTIN4; PRR4; PVRL4; nectin-4",
        "protein_names_uniprotkb": "Nectin-4; Ig superfamily receptor LNIR; Nectin cell adhesion molecule 4; Poliovirus receptor-related protein 4",
        "protein_names_refseq": "Ig superfamily receptor LNIR; nectin 4; nectin-4 precursor; poliovirus receptor-related 4; poliovirus receptor-related protein 4",
        "tax_id": 9606,
        "disease": "ectodermal dysplasia-syndactyly syndrome 1 (MONDO:MONDO:0024565)",
        "pathway": " (hsa:81607);  (R-HSA-418990);  (R-HSA-420597)",
        "pathway_count": 3,
        "publication_count": 31,
        "publication_id_list": "10.1101/2023.09.13.557529;10225955;11544254;12011057;12050160;12759359;15741237;15784625;16467305;17474988;17967169;19354288;20691405;22048310;22902367;23090970;23202587;24190977;25372031;25576301;28904123;29741879;32938616;37829154;38062106;38063270;38196202;39009071;7806582;9219219;9845526",
        "class_list": "",
        "function": "(Microbial infection) Acts as a receptor for measles virus., [UniProtKB, PubMed, PubMed]; A Recurrent Nonsense Mutation in NECTIN4 Underlying Ectodermal Dysplasia-Syndactyly Syndrome with a Novel Phenotype in a Consanguineous Kashmiri Family. Publication Status: Online-Only, [RefSeq, PubMed]; Associations of TACSTD2/TROP2 and NECTIN-4/NECTIN-4 with molecular subtypes, PD-L1 expression, and FGFR3 mutational status in two advanced urothelial bladder cancer cohorts., [RefSeq, PubMed]; Expression of PVRL4, a molecular target for cancer treatment, is transcriptionally regulated by FOS., [RefSeq, PubMed]; Molecular Crosstalk Between Adherens Junction Proteins, E-cadherin and Nectin-4., [RefSeq, PubMed]; Nectin-4 regulates cellular senescence-associated enlargement of cell size. Publication Status: Online-Only, [RefSeq, PubMed]; Seems to be involved in cell adhesion through trans-homophilic and -heterophilic interactions, the latter including specifically interactions with NECTIN1. Does not act as receptor for alpha-herpesvirus entry into cells., [UniProtKB]; The active form of TACE is overexpressed in breast tumors and may indicate that TACE is responsible for Nectin-4 shedding not only in vitro but also in vivo, [RefSeq, PubMed]; This gene encodes a member of the nectin family. The encoded protein contains two immunoglobulin-like (Ig-like) C2-type domains and one Ig-like V-type domain. It is involved in cell adhesion through trans-homophilic and -heterophilic interactions. It is a single-pass type I membrane protein. The soluble form is produced by proteolytic cleavage at the cell surface by the metalloproteinase ADAM17/TACE. The secreted form is found in both breast tumor cell lines and breast tumor patients. Mutations in this gene are the cause of ectodermal dysplasia-syndactyly syndrome type 1, an autosomal recessive disorder. Alternatively spliced transcript variants have been found but the full-length nature of the variant has not been determined.[provided by RefSeq, Jan 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 8593,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DQW3;Q96K15",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0001618 virus receptor activity;GO:0048018 receptor ligand activity;GO:0098631 cell adhesion mediator activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005912 adherens junction;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007157 heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules;GO:0045953 negative regulation of natural killer cell mediated cytotoxicity",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q96NY8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N7B6-1",
        "uniprot_id": [
            {
                "id": "PACRL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N7B6",
                "type": "external"
            }
        ],
        "mass": 27152.0,
        "length": 248,
        "protein_name": "PACRG-like protein",
        "gene_name": "PACRGL",
        "organism": "Human",
        "refseq_name": "PACRG-like protein isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001124199",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001124199",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PACRGL; C4orf28",
        "gene_names_refseq": "C4orf28; PACRGL",
        "protein_names_uniprotkb": "PACRG-like protein",
        "protein_names_refseq": "PACRG-like protein isoform 2; PACRG-like protein; PARK2 co-regulated like; PARK2 coregulated like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:133015)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "11237011;25576301;28904123;30315122;30379171;30429286;31217245;31844290;32157095;32265295;32357974;32713345;33968037;35051231;36010968",
        "class_list": "",
        "function": "Exosomal circPACRGL promotes progression of colorectal cancer via the miR-142-3p/miR-506-3p- TGF-beta1 axis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
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    },
    {
        "uniprot_canonical_ac": "Q8NG66-1",
        "uniprot_id": [
            {
                "id": "NEK11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NG66",
                "type": "external"
            }
        ],
        "mass": 74192.0,
        "length": 645,
        "protein_name": "Serine/threonine-protein kinase Nek11",
        "gene_name": "NEK11",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase Nek11 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001139475",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139475",
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        "gene_names_refseq": "NEK11",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase Nek11; 2.7.11.1; Never in mitosis A-related kinase 11; NimA-related protein kinase 11",
        "protein_names_refseq": "NIMA (never in mitosis gene a)- related kinase 11; serine/threonine-protein kinase NEK11; serine/threonine-protein kinase Nek11 isoform 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79858);  (R-HSA-69601)",
        "pathway_count": 2,
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        "publication_id_list": "10827953;11237011;11298456;12154088;12234927;12399544;12676583;12676925;12759351;12963847;14603323;14681206;15161910;17344846;18167338;18480045;19734889;20090422;20348946;21252624;26501353;29789417;30429286;31704778;32034166;32488085;35051231;35494241",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
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                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
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            {
                "id": "2.7.1.154",
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                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
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                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
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            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
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                "id": "2.7.11.17",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
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                "id": "2.7.11.19",
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                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
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                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
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        ],
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0035556 intracellular signal transduction;GO:0031573 mitotic intra-S DNA damage checkpoint signaling;GO:1901990 regulation of mitotic cell cycle phase transition",
        "synthesized_glycan_count": 0,
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        "kg_view_protein": true
    },
    {
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                "id": "MTMRA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NXD2",
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            }
        ],
        "mass": 88273.0,
        "length": 777,
        "protein_name": "Myotubularin-related protein 10",
        "gene_name": "MTMR10",
        "organism": "Human",
        "refseq_name": "myotubularin-related protein 10",
        "refseq_ac": [
            {
                "id": "NP_060232",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060232",
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            }
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        "gene_names_uniprotkb": "MTMR10",
        "gene_names_refseq": "MTMR10",
        "protein_names_uniprotkb": "Myotubularin-related protein 10; Inactive phosphatidylinositol 3-phosphatase 10",
        "protein_names_refseq": "inactive phosphatidylinositol 3-phosphatase 10; myotubularin-related protein 10",
        "tax_id": 9606,
        "disease": "neurodegenerative disease (Disease Ontology:DOID:1289)",
        "pathway": " (hsa:54893);  (R-HSA-1660516)",
        "pathway_count": 2,
        "publication_count": 65,
        "publication_id_list": "10.1101/2023.09.13.557529;10419465;10766823;10805725;11237011;11302699;11706043;11733541;11923287;12847286;15716355;1655747;16787938;17556371;17651088;18524850;18950639;19413330;19664995;19901323;20068231;21081650;23818870;24275569;24714562;24715725;25418920;25576301;25869668;26154972;26496610;26992070;27846572;27862975;28218747;28832583;28834231;28904123;29242379;29437277;29557506;29786170;30379171;30429286;31154438;31217245;31844290;32157095;32161166;32387766;32502341;32938616;32983136;33912179;34357683;34509645;34932366;35051231;35580925;36284347;37938771;7608176;7628435;8999962;9295334",
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        "mass": 59621.0,
        "length": 548,
        "protein_name": "T-complex protein 1 subunit theta",
        "gene_name": "CCT8",
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        "refseq_name": "T-complex protein 1 subunit theta isoform 2",
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            {
                "id": "NP_001269836",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269836",
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            }
        ],
        "gene_names_uniprotkb": "CCT8; C21orf112; CCTQ; KIAA0002",
        "gene_names_refseq": "C21orf112; CCT8; Cctq; D21S246; PRED71",
        "protein_names_uniprotkb": "T-complex protein 1 subunit theta; 3.6.1.-; CCT-theta; Chaperonin containing T-complex polypeptide 1 subunit 8; Renal carcinoma antigen NY-REN-15; TCP-1-theta",
        "protein_names_refseq": "CCT-theta; T-complex protein 1 subunit theta isoform 2; T-complex protein 1 subunit theta; TCP-1-theta; chaperonin containing T-complex polypeptide 1 subunit 8; chaperonin containing TCP1, subunit 8 (theta); renal carcinoma antigen NY-REN-15",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10694);  (R-HSA-389957);  (R-HSA-389960);  (R-HSA-390450);  (R-HSA-390471);  (R-HSA-5620922);  (R-HSA-6798695);  (R-HSA-6814122)",
        "pathway_count": 8,
        "publication_count": 178,
        "publication_id_list": "10508479;11237011;11252952;12502735;14532270;14654843;15258860;15314642;15592455;15889144;16408927;16497976;16702223;16717095;17574030;17697703;17924679;18669648;18775504;18991276;19011634;19081074;19376773;19421068;19575670;19608861;19651622;19690332;20068231;20080638;20233871;20305658;20603001;21098288;21427764;21872626;21993680;21995946;22072986;22139371;22389062;22424782;22500027;22967762;23186163;23351793;23481700;23637185;23650620;23719902;23747015;24296415;24366607;24714562;24715725;24756126;25114211;25218447;25342745;25418920;25443296;25446516;25467444;25502872;25505266;25576301;25645385;25659125;25675501;25755297;25810538;25880248;25892735;26154972;26375851;26728094;26811146;26853435;26929215;26992070;27397612;27600516;27846572;27862975;28832583;28834231;28904123;29242379;29317506;29393594;29437277;29493099;29508533;29557506;29632046;29786170;30315122;30397120;30410026;30429286;30484775;30626607;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31937595;31998317;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32870666;32897882;32938616;32983136;33123756;33141586;33214551;33298915;33392160;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34211107;34357683;34433824;34509645;34561969;34725712;34932366;35051231;35083852;35138101;35154160;35251023;35254053;35318648;35449234;35561310;35580925;36010968;36215666;36241641;36284347;36493755;36581221;37193829;37217939;37938771;38665916;39480921;40307207;40596516;40914422;40930100;7890169;8590283;8692836;9153422;9819444",
        "class_list": "",
        "function": "Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444). As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia (PubMed:20080638)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; This gene encodes the theta subunit of the CCT chaperonin, which is abundant in the eukaryotic cytosol and may be involved in the transport and assembly of newly synthesized proteins. Alternative splicing results in multiple transcript variants of this gene. A pseudogene related to this gene is located on chromosome 1. [provided by RefSeq, Sep 2013]., [RefSeq]",
        "predicted_glycosites": 0,
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            {
                "id": "3.6.1.6",
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            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
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            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
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            },
            {
                "id": "3.4.19.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.9",
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            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
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            {
                "id": "5.4.2.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.4.2.7",
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            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
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            {
                "id": "3.4.25.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1",
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            },
            {
                "id": "1.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.5.5",
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            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
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            {
                "id": "3.1.13.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
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            },
            {
                "id": "5.6.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
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            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
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            {
                "id": "3.1.13.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-",
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            {
                "id": "5.3.99.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.99.3",
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                "id": "2.7.1.91",
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            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
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            {
                "id": "3.5.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.4",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.18.1",
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        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0045296 cadherin binding;GO:0044183 protein folding chaperone",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol;GO:0005874 microtubule",
        "go_biological_process": "GO:1904871 positive regulation of protein localization to Cajal body;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:1904874 positive regulation of telomerase RNA localization to Cajal body",
        "synthesized_glycan_count": 0,
        "hit_score": 18.3,
        "record_id": "P50990-1",
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    {
        "uniprot_canonical_ac": "P59046-1",
        "uniprot_id": [
            {
                "id": "NAL12_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P59046",
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        ],
        "mass": 120173.0,
        "length": 1061,
        "protein_name": "NACHT, LRR and PYD domains-containing protein 12",
        "gene_name": "NLRP12",
        "organism": "Human",
        "refseq_name": "NACHT, LRR and PYD domains-containing protein 12 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001264055",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264055",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NLRP12; NALP12; PYPAF7; RNO",
        "gene_names_refseq": "CLR19.3; FCAS2; NALP12; NLRP12; PAN6; PYPAF7; RNO2; RNO",
        "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 12; Monarch-1; PYRIN-containing APAF1-like protein 7; Regulated by nitric oxide",
        "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 12 isoform 3; NACHT, LRR and PYD domains-containing protein 12; PYRIN-containing APAF1-like protein 7; monarch 1; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 12; regulated by nitric oxide",
        "tax_id": 9606,
        "disease": "familial cold autoinflammatory syndrome 2 (Disease Ontology:DOID:0090063)",
        "pathway": " (hsa:91662);  (R-HSA-9705671)",
        "pathway_count": 2,
        "publication_count": 81,
        "publication_id_list": "11167794;11237011;12019269;12563287;12692549;12759408;15208624;16203735;17237370;17947705;18160710;18230725;21978668;22941947;26992070;28112203;28411811;29393594;30559449;30902577;31850239;32353859;32357974;32387766;32428392;32589897;32726803;32728199;32938616;32953130;32979938;32983136;33024073;33060197;33097660;33110251;33349665;33360543;33372174;33372854;33396605;33440148;33479219;33495715;33514628;33567255;33718825;33723219;33723527;33727702;33801464;33807682;33849972;33895773;33963333;33989516;33990585;34021074;34054808;34084167;34110168;34166398;34239064;34290717;34341353;34375313;34400613;34439781;34452305;34471099;34502139;34597346;35051231;35102342;35494241;35643212;37051252;38123482;38177227;38261657;39181275",
        "class_list": "",
        "function": "Monarch-1 associates with IRAK-1 but not MyD88, resulting in the blockage of IRAK-1 hyperphosphorylation, [RefSeq, PubMed]; Monarch-1 enhances nonclassical and classical major histocompatibility complex class I expression at the level of the promoter, RNA, and protein expression., [RefSeq, PubMed]; Monarch-1 inhibits CD40-mediated activation of NF-kappaB via the non-canonical pathway in human monocytes. This inhibition stems from the ability of Monarch-1 to associate with and induce proteasome-mediated degradation of NF-kappaB inducing kinase, [RefSeq, PubMed]; NLRP12 c.1382dup promotes the development of Crohn's disease through the ERK/NLRP3/ IL-1beta pathway., [RefSeq, PubMed]; NLRP12 interacts with NLRP3 to block the activation of the human NLRP3 inflammasome., [RefSeq, PubMed]; NLRP12-associated autoinflammatory disease in Chinese adult patients: a single-centre study. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Plays an essential role as an potent mitigator of inflammation (PubMed:30559449). Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways (PubMed:15489334, PubMed:17947705). Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway (PubMed:30559449). In turn, promotes bacterial tolerance (PubMed:30559449). Also inhibits the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation (PubMed:30902577). Also acts as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; Plays an essential role as an potent mitigator of inflammation. Primarily expressed in dendritic cells and macrophages, inhibits both canonical and non-canonical NF-kappa-B and ERK activation pathways. Functions as a negative regulator of NOD2 by targeting it to degradation via the proteasome pathway. In turn, promotes bacterial tolerance. Also inhibits the RIGI-mediated immune signaling against RNA viruses by reducing the E3 ubiquitin ligase TRIM25-mediated 'Lys-63'-linked RIGI activation but enhancing the E3 ubiquitin ligase RNF125-mediated 'Lys-48'-linked RIGI degradation. Also acts as a negative regulator of inflammatory response to mitigate obesity and obesity-associated diseases in adipose tissue., [UniProtKB, UniProtKB, UniProtKB]; Regulates activation of NF-kappa B and caspase-1-dependent cytokine processing, [RefSeq, PubMed]; The contributions of deleterious rare alleles in NLRP12 and inflammasome-related genes to polymyalgia rheumatica. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the CATERPILLER family of cytoplasmic proteins. The encoded protein, which contains an N-terminal pyrin domain, a NACHT domain, a NACHT-associated domain, and a C-terminus leucine-rich repeat region, functions as an attenuating factor of inflammation by suppressing inflammatory responses in activated monocytes. Mutations in this gene cause familial cold autoinflammatory syndrome type 2. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
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        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
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        "reported_snv": 29,
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        "biomarker_type": "",
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        "secondary_ac_list": "A8MTQ2;B3KTE7;Q8NEU4;Q9BY26",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0030674 protein-macromolecule adaptor activity;GO:0140608 cysteine-type endopeptidase activator activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0007165 signal transduction;GO:1901224 positive regulation of non-canonical NF-kappaB signal transduction;GO:0032715 negative regulation of interleukin-6 production;GO:0050728 negative regulation of inflammatory response;GO:0043124 negative regulation of canonical NF-kappaB signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "P59046-1",
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    },
    {
        "uniprot_canonical_ac": "Q8TB73-1",
        "uniprot_id": [
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                "id": "NDNF_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TB73",
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            }
        ],
        "mass": 64673.0,
        "length": 568,
        "protein_name": "Protein NDNF",
        "gene_name": "NDNF",
        "organism": "Human",
        "refseq_name": "protein NDNF precursor",
        "refseq_ac": [
            {
                "id": "NP_078850",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078850",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NDNF; C4orf31; PRO6487",
        "gene_names_refseq": "C4orf31; HH25; NDNF; NORD",
        "protein_names_uniprotkb": "Protein NDNF; Neuron-derived neurotrophic factor",
        "protein_names_refseq": "fibronectin type-III domain-containing protein C4orf31; protein NDNF precursor; protein NDNF",
        "tax_id": 9606,
        "disease": "hypogonadotropic hypogonadism (Disease Ontology:DOID:0090070); hypogonadotropic hypogonadism 25 with anosmia (MONDO:MONDO:0030010)",
        "pathway": " (hsa:79625)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "11237011;12975309;16970039;20332099;20969804;24706764;27862975;29242379;30429286;31852841;31883645;32157095;35051231;38801165",
        "class_list": "",
        "function": "Direct duplication of chromosome 4q27q31.3 de novo results in partial trisomy of its long arm., [RefSeq, PubMed]; NDNF acts as an endogenous modulator that promotes endothelial cell function and ischemia-induced revascularization through eNOS-dependent mechanisms, [RefSeq, PubMed]; Neuron-Derived Neurotrophic Factor Is Mutated in Congenital Hypogonadotropic Hypogonadism., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Erratum:[Hum Mol Genet. 2010 Oct 15;19(20):4121. Hesselbrock, Victor [added]; Tischfield, Jay A [added]], [RefSeq, PubMed]; Overexpression of NDNF Improves the Cytoprotective Effects of Aged Human Bone Marrow Mesenchymal Stem Cells by Modulating Oxidative Stress and Apoptosis., [RefSeq, PubMed]; Secretome profiling identifies neuron-derived neurotrophic factor as a tumor-suppressive factor in lung cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Secretory protein that plays a role in various cellular processes (PubMed:20969804, PubMed:24706764, PubMed:31883645). Acts as a chemorepellent acting on gonadotropin-releasing hormone (GnRH) expressing neurons regulating their migration to the hypothalamus (PubMed:31883645). Also promotes neuron migration, growth and survival as well as neurite outgrowth and is involved in the development of the olfactory system (PubMed:20969804, PubMed:31883645). May also act through the regulation of growth factors activity and downstream signaling (PubMed:31883645). Also regulates extracellular matrix assembly and cell adhesiveness (By similarity). Promotes endothelial cell survival, vessel formation and plays an important role in the process of revascularization through NOS3-dependent mechanisms (PubMed:24706764)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 2,
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        "secondary_ac_list": "A8K0Q0;Q6UWE5;Q9H5P7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008201 heparin binding;GO:0005539 glycosaminoglycan binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0002931 response to ischemia;GO:0010976 positive regulation of neuron projection development;GO:0030198 extracellular matrix organization;GO:0001764 neuron migration",
        "synthesized_glycan_count": 0,
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        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
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                "url": "https://www.uniprot.org/uniprot/Q96S19",
                "type": "external"
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        ],
        "mass": 22578.0,
        "length": 204,
        "protein_name": "Methyltransferase-like 26",
        "gene_name": "METTL26",
        "organism": "Human",
        "refseq_name": "methyltransferase-like 26 isoform b",
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            {
                "id": "NP_001035250",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035250",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "METTL26; C16orf13; JFP2",
        "gene_names_refseq": "C16orf13; JFP2; METTL26",
        "protein_names_uniprotkb": "Methyltransferase-like 26",
        "protein_names_refseq": "UPF0585 protein C16orf13; methyltransferase-like 26 isoform b",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84326)",
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        "publication_count": 68,
        "publication_id_list": "11237011;20068231;20797691;22424782;22544926;22898188;23481700;24715725;25418920;25505266;25576301;25645385;26154972;26811146;26992070;27600516;27846572;28218747;28228285;28832583;28860189;29242379;29331515;29393594;29437277;29508533;29557506;30315122;30410026;30429286;30524438;30779550;31154438;31222486;31530632;31844290;31848261;31937595;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33936100;33968037;33981976;34087483;34171305;34211107;34357683;34405274;34509645;34561969;35051231;35580925;36010968;36215666;37938771",
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        "secondary_ac_list": "A8MTR1;A8MWJ8;A8MZA1;B4DG95;B4DIJ3;D6REA6;F6TF62;F6VM53;Q96IW1;Q96MD6",
        "ec_number_list": [],
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        "synthesized_glycan_count": 0,
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        "record_id": "Q96S19-1",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O94832-1",
        "uniprot_id": [
            {
                "id": "MYO1D_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O94832",
                "type": "external"
            }
        ],
        "mass": 116202.0,
        "length": 1006,
        "protein_name": "Unconventional myosin-Id",
        "gene_name": "MYO1D",
        "organism": "Human",
        "refseq_name": "unconventional myosin-Id isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001290208",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001290208",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO1D; KIAA0727",
        "gene_names_refseq": "MYO1D; PPP1R108; myr4",
        "protein_names_uniprotkb": "Unconventional myosin-Id",
        "protein_names_refseq": "myosin-I gamma; protein phosphatase 1, regulatory subunit 108; unconventional myosin-Id isoform 2; unconventional myosin-Id",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4642)",
        "pathway_count": 1,
        "publication_count": 69,
        "publication_id_list": "11237011;18669648;23481700;24714562;25418920;25576301;25645385;25802875;25880248;25892735;26154972;26375851;26811146;26929215;26992070;27600516;27846572;27920218;28218747;28228285;28411811;28514659;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29769354;29786170;29789417;30315122;30410026;30429286;31217245;31844290;32157095;32350084;32357974;32387766;32938616;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33912179;33981976;34019948;34087483;34171305;34185709;34509645;34561969;34932366;35051231;35318648;35580925;36010968;36241641;36284347;37938771;38684630",
        "class_list": "",
        "function": "Identification of a novel MYO1D variant associated with laterality defects, congenital heart diseases, and sperm defects in humans., [RefSeq, PubMed]; Unconventional myosin that functions as actin-based motor protein with ATPase activity (By similarity). Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes (By similarity). Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Unconventional myosin that functions as actin-based motor protein with ATPase activity. Plays a role in endosomal protein trafficking, and especially in the transfer of cargo proteins from early to recycling endosomes. Required for normal planar cell polarity in ciliated tracheal cells, for normal rotational polarity of cilia, and for coordinated, unidirectional ciliary movement in the trachea. Required for normal, polarized cilia organization in brain ependymal epithelial cells., [UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8V3;Q8NHP9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0019904 protein domain specific binding;GO:0048306 calcium-dependent protein binding;GO:0051015 actin filament binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0005903 brush border",
        "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0015031 protein transport;GO:0030048 actin filament-based movement;GO:0061502 early endosome to recycling endosome transport",
        "synthesized_glycan_count": 0,
        "hit_score": 7.2,
        "record_id": "O94832-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N130-1",
        "uniprot_id": [
            {
                "id": "NPT2C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N130",
                "type": "external"
            }
        ],
        "mass": 63550.0,
        "length": 599,
        "protein_name": "Sodium-dependent phosphate transport protein 2C",
        "gene_name": "SLC34A3",
        "organism": "Human",
        "refseq_name": "sodium-dependent phosphate transport protein 2C",
        "refseq_ac": [
            {
                "id": "NP_001170787",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001170787",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC34A3; NPT2C; NPTIIC",
        "gene_names_refseq": "HHRH; NPT2C; NPTIIc; SLC34A3",
        "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 2C; Na(+)-dependent phosphate cotransporter 2C; Na(+)/Pi cotransporter 2C; NaPi-2c; Sodium-phosphate transport protein 2C; Sodium/inorganic phosphate cotransporter IIC; Sodium/phosphate cotransporter 2C; Solute carrier family 34 member 3",
        "protein_names_refseq": "Na(+)-dependent phosphate cotransporter 2C; Na(+)/Pi cotransporter 2C; naPi-2c; sodium-dependent phosphate transport protein 2C; sodium-phosphate transport protein 2C; sodium/inorganic phosphate cotransporter IIC; solute carrier family 34 (sodium phosphate), member 3; solute carrier family 34 (type II sodium/phosphate cotransporter), member 3; type IIc Na+/Pi cotransporter",
        "tax_id": 9606,
        "disease": "hereditary hypophosphatemic rickets with hypercalciuria (Disease Ontology:DOID:0050947)",
        "pathway": " (hsa:142680);  (R-HSA-427589);  (R-HSA-5619097)",
        "pathway_count": 3,
        "publication_count": 24,
        "publication_id_list": "10198426;10329428;11237011;11880379;12324554;12379267;15504899;16358214;16358215;16955105;16960801;24246249;25645385;31844290;32311027;32725396;32938616;33968037;34211107;34509645;35051231;36596813;37414395;8327470",
        "class_list": "",
        "function": "Digenic Heterozygous Mutations in SLC34A3 and SLC34A1 Cause Dominant Hypophosphatemic Rickets with Hypercalciuria., [RefSeq, PubMed]; Functionally important sites in the predicted first and fourth extracellular linkers of the type IIa Na+/Pi cotransporter (NaPi-IIa) were identified by cysteine scanning mutagenesis (Ehnes et al., 2004)., [RefSeq, PubMed]; Involved in actively transporting phosphate into cells via Na(+) cotransport in the renal brush border membrane (PubMed:11880379). The cotransport has a Na(+):Pi stoichiometry of 2:1 and is electroneutral (By similarity)., [UniProtKB, PubMed, UniProtKB]; Loss of function of the SLC34A3 protein presumably results in a primary renal tubular defect and is compatible with the hereditary hypophosphatemic rickets with hypercalciuria phenotype., [RefSeq, PubMed]; NaP(i)-IIc has a key role in the regulation of phosphate homeostasis., [RefSeq, PubMed]; Rare variants in the sodium-dependent phosphate transporter gene SLC34A3 explain missing heritability of urinary stone disease., [RefSeq, PubMed]; Relationship between clinical phenotype and in vitro analysis of 13 NPT2c/SCL34A3 mutants. Publication Status: Online-Only, [RefSeq, PubMed]; The genetic polymorphisms of XPR1 and SCL34A3 are associated with Fanconi syndrome in Chinese patients of tumor-induced osteomalacia., [RefSeq, PubMed]; Therefore, understanding the mechanisms that control the apical expression of NaPi-IIa and NaPi-IIc as well as their functional properties is critical to understanding how an organism achieves P i homeostasis. Review article, [RefSeq, PubMed]; This gene encodes a member of SLC34A transporter family of proteins, and is expressed primarily in the kidney. It is involved in transporting phosphate into cells via sodium cotransport in the renal brush border membrane, and contributes to the maintenance of inorganic phosphate concentration in the kidney. Mutations in this gene are associated with hereditary hypophosphatemic rickets with hypercalciuria. Alternatively spliced transcript variants varying in the 5' UTR have been found for this gene.[provided by RefSeq, Apr 2010]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2BFA1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005436 sodium:phosphate symporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005903 brush border;GO:0016324 apical plasma membrane;GO:0031982 vesicle;GO:0031526 brush border membrane",
        "go_biological_process": "GO:0006814 sodium ion transport;GO:0006817 phosphate ion transport;GO:0035435 phosphate ion transmembrane transport;GO:0030643 intracellular phosphate ion homeostasis;GO:0044341 sodium-dependent phosphate transport",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "Q8N130-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15438-1",
        "uniprot_id": [
            {
                "id": "MRP3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15438",
                "type": "external"
            }
        ],
        "mass": 169343.0,
        "length": 1527,
        "protein_name": "ATP-binding cassette sub-family C member 3",
        "gene_name": "ABCC3",
        "organism": "Human",
        "refseq_name": "ATP-binding cassette sub-family C member 3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001137542",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137542",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ABCC3; CMOAT2; MLP2; MRP3",
        "gene_names_refseq": "ABC31; ABCC3; EST90757; MLP2; MOAT-D; MRP3; cMOAT2",
        "protein_names_uniprotkb": "ATP-binding cassette sub-family C member 3; 7.6.2.-; 7.6.2.2; 7.6.2.3; Canalicular multispecific organic anion transporter 2; MOAT-D; Multi-specific organic anion transporter D; Multidrug resistance-associated protein 3",
        "protein_names_refseq": "ATP-binding cassette sub-family C member 3 isoform 2; ATP-binding cassette sub-family C member 3; ATP-binding cassette, sub-family C (CFTR/MRP), member 3; canalicular multispecific organic anion transporter 2; canicular multispecific organic anion transporter; multi-specific organic anion transporter D; multidrug resistance associated protein; multidrug resistance-associated protein 3",
        "tax_id": 9606,
        "disease": "metabolic dysfunction-associated steatotic liver disease (Disease Ontology:DOID:0080208); Dubin-Johnson syndrome (Disease Ontology:DOID:12308); hyperprolactinemia (Disease Ontology:DOID:12700); cholestasis (Disease Ontology:DOID:13580); pancreatic cancer (Disease Ontology:DOID:1793); bilirubin metabolic disorder (Disease Ontology:DOID:2741); kidney disease (Disease Ontology:DOID:557); hepatocellular carcinoma (Disease Ontology:DOID:684); end stage renal disease (Disease Ontology:DOID:783); acute myeloid leukemia (Disease Ontology:DOID:9119); steatotic liver disease (Disease Ontology:DOID:9452)",
        "pathway": " (hsa:8714);  (R-HSA-159418);  (R-HSA-382556);  (R-HSA-9749641);  (R-HSA-9753281);  (R-HSA-9818032)",
        "pathway_count": 6,
        "publication_count": 229,
        "publication_id_list": "10.1101/2023.09.13.557529;10094960;10220572;10334992;10334993;10358072;10359813;10434065;10484077;10601278;10665657;10741631;10748049;10884298;10987286;11159893;11237011;11387316;11504826;11562789;11581266;11714888;11812794;11870371;11980911;12220224;12379217;12379510;12393883;12403779;12404239;12404240;12473676;12486725;12604685;12616642;12663868;12704183;12815072;13416382;1352877;1356264;1359686;13741103;1377674;14661924;14699511;14759258;15083066;15175422;15472518;15863492;15899824;16258079;16317684;16541101;16696573;16816140;16837570;16858120;16901789;16908160;16943252;17440952;17482904;17523162;17627974;17650074;1783992;17855752;17894550;17924658;17977821;18232020;18282684;18313914;18357469;18434309;18669648;19002207;19447222;19463;19570978;19651622;1968359;19836360;19842618;19862647;1998343;20068231;20190787;2037576;20583968;20621639;20682644;20878951;21666065;21712391;21932426;22178883;22349737;22406294;22674043;23018617;23063411;23186163;23337244;23667609;23682772;24019521;24275569;24685677;2475911;24992895;25133187;25349122;25576301;25662406;2570070;2573352;25840124;26049587;26067475;26154972;26208431;26325606;27549314;27703488;27846572;27862975;28112439;28132103;28188670;28408210;28411811;28416261;28622427;28677105;28832583;2898143;29242379;29331515;29393594;29557506;29632711;29769354;29786170;29790264;29938870;30315122;30429286;30779550;30833945;31154438;31771235;31844290;31848261;32157095;32236612;32350084;32387766;32472168;32488085;32938616;32981041;32983136;33392160;3342084;33437477;33537174;33592498;3395122;33968037;33981976;34087483;34171305;34185709;3457471;3472246;35008510;35051231;35307651;35318648;35328066;35494241;35580925;36010968;36241641;36284347;3705620;37938771;38566304;38642845;39894887;41018975;5013373;5773090;5862532;6777177;6838677;6950087;70646;7077161;7206363;7469630;7523390;7529176;7553863;7553864;7557095;7588781;7802672;7865904;8034703;8132774;8813074;9024171;9080;9144407;9270026;931988;9652413;9738950;975718;9813153;9816258;9827529;9831708;9889399",
        "class_list": "",
        "function": "ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes (PubMed:10359813, PubMed:11581266, PubMed:15083066). Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4) (PubMed:11581266, PubMed:15083066). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate) (By similarity). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes (By similarity). May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells (PubMed:10359813, PubMed:11581266)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Association Study of SLCO1B3 and ABCC3 Genetic Variants in Gallstone Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Downregulation of ABCC3 activates MAPK signaling through accumulation of deoxycholic acid in colorectal cancer cells., [RefSeq, PubMed]; SMARCA4 (BRG1) activates ABCC3 transcription to promote hepatocellular carcinogenesis., [RefSeq, PubMed]; The Role of TRIP6, ABCC3 and CPS1 Expression in Resistance of Ovarian Cancer to Taxanes. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. The specific function of this protein has not yet been determined; however, this protein may play a role in the transport of biliary and intestinal excretion of organic anions. Alternatively spliced variants which encode different protein isoforms have been described; however, not all variants have been fully characterized. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 11,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RPA9;D3DTX9;O60265;O60922;O75621;O95078;O95289;O95290;Q86X85;Q9UN52",
        "ec_number_list": [
            {
                "id": "7.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.2",
                "type": "external"
            },
            {
                "id": "7.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.-",
                "type": "external"
            },
            {
                "id": "7.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.3",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0005524 ATP binding;GO:0042626 ATPase-coupled transmembrane transporter activity;GO:0008559 ABC-type xenobiotic transporter activity;GO:0015432 ABC-type bile acid transporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane;GO:0009925 basal plasma membrane",
        "go_biological_process": "GO:0055085 transmembrane transport;GO:0015721 bile acid and bile salt transport;GO:0006805 xenobiotic metabolic process;GO:0006855 xenobiotic transmembrane transport;GO:0042908 xenobiotic transport",
        "synthesized_glycan_count": 0,
        "hit_score": 23.4,
        "record_id": "O15438-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y210-1",
        "uniprot_id": [
            {
                "id": "TRPC6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y210",
                "type": "external"
            }
        ],
        "mass": 106326.0,
        "length": 931,
        "protein_name": "Short transient receptor potential channel 6",
        "gene_name": "TRPC6",
        "organism": "Human",
        "refseq_name": "short transient receptor potential channel 6 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_004612",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004612",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TRPC6; TRP6",
        "gene_names_refseq": "FSGS2; TRP6; TRPC6",
        "protein_names_uniprotkb": "Short transient receptor potential channel 6; TRP-6; Transient receptor protein 6; TrpC6",
        "protein_names_refseq": "TRP-6; focal segmental glomerulosclerosis 2; short transient receptor potential channel 6 isoform 1; short transient receptor potential channel 6; transient receptor protein 6",
        "tax_id": 9606,
        "disease": "nicotine dependence (Disease Ontology:DOID:0050742); nephrotic syndrome type 2 (Disease Ontology:DOID:0080379); focal segmental glomerulosclerosis 2 (Disease Ontology:DOID:0111129); focal segmental glomerulosclerosis (Disease Ontology:DOID:1312); transient cerebral ischemia (Disease Ontology:DOID:224); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); pulmonary hypertension (Disease Ontology:DOID:6432); chronic fatigue syndrome (Disease Ontology:DOID:8544); type 2 diabetes mellitus (Disease Ontology:DOID:9352)",
        "pathway": " (hsa:7225);  (R-HSA-114508);  (R-HSA-139853);  (R-HSA-3295583);  (R-HSA-418890)",
        "pathway_count": 5,
        "publication_count": 63,
        "publication_id_list": "10816590;11050376;11080611;11226139;11237011;11243859;11301059;11413485;11805119;12015988;12970363;1422598;14634208;15757897;15879175;15924139;17850865;18088087;19033211;19124028;19458060;19936226;19961855;20025796;20716668;20798252;21511817;21734084;2175712;22001259;22732337;23014460;23291369;24190977;2457808;25389312;25765567;25855297;26892346;28228285;28877958;29493099;29557506;29671580;32387766;34171305;35051231;35494241;35580925;36010968;36241641;36936781;37938771;37980653;38003608;38069081;38565515;39098247;8646775;9565569;9601053;9925922;9930701",
        "class_list": "",
        "function": "A Putative Role for TRPC6 in Immune-Mediated Kidney Injury. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Immunohistochemical expression of the cation channel TRPC6 in the submandibular and lacrimal gland and in salivary gland tumors., [RefSeq, PubMed]; Non-selective, calcium-permeable cation channel (PubMed:19936226, PubMed:23291369, PubMed:26892346, PubMed:9930701). Mediates calcium entry following G(q)-coupled receptor or receptor tyrosine kinase activation, which triggers phospholipase C (PLC)-mediated hydrolysis of phosphatidylinositides and production of diacylglycerol (DAG) that directly activates TRPC6 (PubMed:26892346). Does not appear to be activated by depletion of intracellular calcium stores (PubMed:9930701). Mediates depolarization of intrinsically photosensitive retinal ganglion cells (ipRGCs) in response to light-induced melanopsin (OPN4)-mediated phototransduction via G(q)-PLC signaling, likely by forming heteromeric TRPC6-TRPC7 channels (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed]; Renal ischaemia-reperfusion injury is promoted by transcription factor NF-kB p65, which inhibits TRPC6 expression by activating miR-150., [RefSeq, PubMed]; TRPC6 Deletion Enhances eNOS Expression and Reduces LPS-Induced Acute Lung Injury. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene forms a receptor-activated calcium channel in the cell membrane. The channel is activated by diacylglycerol and is thought to be under the control of a phosphatidylinositol second messenger system. Activation of this channel occurs independently of protein kinase C and is not triggered by low levels of intracellular calcium. Defects in this gene are a cause of focal segmental glomerulosclerosis 2 (FSGS2). [provided by RefSeq, Mar 2009]., [RefSeq]; [Expansion of the genotypic and phenotypic spectrum and treatment of four children with Steroid-resistant nephrotic syndrome due to variants of TRPC6 gene]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 3,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 3,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 10,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q52M59;Q9HCW3;Q9NQA8;Q9NQA9",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005262 calcium channel activity;GO:0042803 protein homodimerization activity;GO:0005261 monoatomic cation channel activity;GO:0015279 store-operated calcium channel activity",
        "go_cellular_component": "GO:0034703 cation channel complex;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0036057 slit diaphragm",
        "go_biological_process": "GO:0051480 regulation of cytosolic calcium ion concentration;GO:0007338 single fertilization;GO:0006812 monoatomic cation transport;GO:0032414 positive regulation of ion transmembrane transporter activity;GO:0070588 calcium ion transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "Q9Y210-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100010000001.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14135-1",
        "uniprot_id": [
            {
                "id": "VGLL4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14135",
                "type": "external"
            }
        ],
        "mass": 30930.0,
        "length": 290,
        "protein_name": "Transcription cofactor vestigial-like protein 4",
        "gene_name": "VGLL4",
        "organism": "Human",
        "refseq_name": "transcription cofactor vestigial-like protein 4 isoform b",
        "refseq_ac": [
            {
                "id": "NP_055482",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055482",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "VGLL4; KIAA0121",
        "gene_names_refseq": "VGL-4; VGLL4",
        "protein_names_uniprotkb": "Transcription cofactor vestigial-like protein 4; Vgl-4",
        "protein_names_refseq": "Vestigial-like 4; transcription cofactor vestigial-like protein 4 isoform b; transcription cofactor vestigial-like protein 4; vestigial like 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9686)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;15140898;17322306;18669648;18767875;19240061;19413330;19651622;19664995;20068231;20702774;21839727;23186163;29485866;31848261;31937595;31998317;34004031;34075638;34396425;36657637",
        "class_list": "",
        "function": "Biochemical properties of VGLL4 from Homo sapiens and Tgi from Drosophila melanogaster and possible biological implications., [RefSeq, PubMed]; HOXB13 suppresses proliferation, migration and invasion, and promotes apoptosis of gastric cancer cells through transcriptional activation of VGLL4 to inhibit the involvement of TEAD4 in the Hippo signaling pathway., [RefSeq, PubMed]; IRF2BP2 was identifies as a novel VGLL4 partner., [RefSeq, PubMed]; May act as a specific coactivator for the mammalian TEFs., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; VGLL4 inhibits YAP1/TEAD signaling to suppress the epidermal squamous cell carcinoma cancer phenotype., [RefSeq, PubMed]; VGLL4-TEAD1 promotes vascular smooth muscle cell differentiation from human pluripotent stem cells via TET2., [RefSeq, PubMed]; Vgl-4 may play a role in the apoptotic pathways by regulating translocation of IAPs between different cell compartments., [RefSeq, PubMed]; Vgl-4 modulates the activity of TEF-1 factors and counteracts alpha1-adrenergic activation of gene expression in cardiac myocytes GeneRIF: A transcriptional cofactor of transcriptional enhancer factor-1 (TEF-1) transcription factors.  Interacts with TEF-1 factors through 2 TDU (tondu) motifs.  Controls gene expression in cardiac myocytes. GeneRIF: This gene is named Vestigial-like 4, to distinguish it from 3 previously described genes Vgl-1, Vgl-2 and Vgl-3. Contains 2 motifs, found in the Drosophila transcription cofactor Vestigial, that interact with the TEF-1 family of transcription factors., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
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        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A075B6E4;B4DTS7;G5E9M7;J3KN68;Q7L5V0;Q9BQ78",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001223 transcription coactivator binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045892 negative regulation of DNA-templated transcription;GO:0030308 negative regulation of cell growth;GO:0030178 negative regulation of Wnt signaling pathway;GO:0045732 positive regulation of protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q14135-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5HYJ1-1",
        "uniprot_id": [
            {
                "id": "TECRL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5HYJ1",
                "type": "external"
            }
        ],
        "mass": 42009.0,
        "length": 363,
        "protein_name": "Trans-2,3-enoyl-CoA reductase-like",
        "gene_name": "TECRL",
        "organism": "Human",
        "refseq_name": "trans-2,3-enoyl-CoA reductase-like isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001010874",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010874",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TECRL; SRD5A2L2",
        "gene_names_refseq": "CPVT3; GPSN2L; SRD5A2L2; TECRL; TERL",
        "protein_names_uniprotkb": "Trans-2,3-enoyl-CoA reductase-like; 1.3.1.-; Steroid 5-alpha-reductase 2-like 2 protein",
        "protein_names_refseq": "glycoprotein, synaptic 2-like; steroid 5 alpha-reductase 2-like 2; steroid 5-alpha-reductase 2-like 2 protein; trans-2,3-enoyl-CoA reductase-like isoform 1",
        "tax_id": 9606,
        "disease": "non-syndromic intellectual disability (Disease Ontology:DOID:0050889); catecholaminergic polymorphic ventricular tachycardia 3 (Disease Ontology:DOID:0060677)",
        "pathway": " (hsa:253017);  (R-HSA-75876)",
        "pathway_count": 2,
        "publication_count": 33,
        "publication_id_list": "10548543;10954726;11237011;11889465;12371743;12482854;12525535;12975357;15469937;16036915;16371355;17379924;17681178;17762044;18003621;18554506;18728184;19505953;19826053;19913121;20628086;20937905;21959040;25787250;26154972;27861123;28904123;30790670;31844290;32173957;35577932;35580925;8075637",
        "class_list": "",
        "function": "A compound heterozygosity in the Tecrl gene (Arg196Gln and c.918+3T > G splice site mutation) was identified in a patient with catecholaminergic polymorphic ventricular tachycardia., [RefSeq, PubMed]; In summary, the authors report that mutations in TECRL are associated with inherited arrhythmias characterized by clinical features of both long QT syndrome and catecholaminergic polymorphic ventricular tachycardia. Publication Status: Online-Only, [RefSeq, PubMed]; Novel variants in TECRL cause recessive inherited CPVT type 3 with severe and variable clinical symptoms., [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; TECRL deficiency results in aberrant mitochondrial function in cardiomyocytes. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene contains a ubiquitin-like domain in the N-terminal region, three transmembrane segments and a C-terminal 3-oxo-5-alpha steroid 4-dehydrogenase domain. The protein belongs to the steroid 5-alpha reductase family. Mutations in this gene result in ventricular tachycardia, catecholaminergic polymorphic, 3. [provided by RefSeq, Apr 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "1.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.-",
                "type": "external"
            },
            {
                "id": "1.3.1.93",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.93",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0102758 very-long-chain enoyl-CoA reductase activity;GO:0016627 oxidoreductase activity, acting on the CH-CH group of donors;GO:0016491 oxidoreductase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0016020 membrane",
        "go_biological_process": "GO:0006665 sphingolipid metabolic process;GO:0042761 very long-chain fatty acid biosynthetic process;GO:0006629 lipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q5HYJ1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P49281-1",
        "uniprot_id": [
            {
                "id": "NRAM2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P49281",
                "type": "external"
            }
        ],
        "mass": 62266.0,
        "length": 568,
        "protein_name": "Natural resistance-associated macrophage protein 2",
        "gene_name": "SLC11A2",
        "organism": "Human",
        "refseq_name": "natural resistance-associated macrophage protein 2 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_000608",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000608",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC11A2; DCT1; DMT1; NRAMP2; SW-cl.20",
        "gene_names_refseq": "AHMIO1; DCT1; DMT1; NRAMP2; SLC11A2",
        "protein_names_uniprotkb": "Natural resistance-associated macrophage protein 2; DMT-1; Divalent cation transporter 1; Divalent metal transporter 1; NRAMP 2; Solute carrier family 11 member 2",
        "protein_names_refseq": "DMT-1; NRAMP 2; divalent cation transporter 1; natural resistance-associated macrophage protein 2 isoform 3; natural resistance-associated macrophage protein 2; solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2; solute carrier family 11 (proton-coupled divalent metal ion transporters), member 2",
        "tax_id": 9606,
        "disease": "restless legs syndrome (Disease Ontology:DOID:0050425); hypochromic microcytic anemia (Disease Ontology:DOID:0050642); Parkinsonism (Disease Ontology:DOID:0080855); iron deficiency anemia (Disease Ontology:DOID:11758); hypochromic anemia (Disease Ontology:DOID:11759); Parkinson's disease (Disease Ontology:DOID:14330); duodenal ulcer (Disease Ontology:DOID:1724); brain ischemia (Disease Ontology:DOID:2316); anemia (Disease Ontology:DOID:2355); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); pneumonia (Disease Ontology:DOID:552)",
        "pathway": " (hsa:4891);  (R-HSA-425410);  (R-HSA-5619048);  (R-HSA-917937)",
        "pathway_count": 4,
        "publication_count": 109,
        "publication_id_list": "10.1101/2023.09.13.557529;10597293;10625641;11237011;11323407;11734551;12209011;12453412;12475959;12504026;12958161;14576842;15001581;15044468;15201052;15459009;15531878;15537541;15692071;15804357;16143108;16160008;16274220;16377569;16407072;16439678;16510471;16959974;16984228;17109629;17211682;17293870;17486601;18194661;19021540;19452451;1946430;19706893;19762596;19762597;20112406;20550936;2154449;22341971;22341972;22736759;23615448;24448823;25319704;25326704;25418920;25491917;25645385;26154972;26811146;26992070;27462458;27681840;28832583;28834231;28904123;29242379;29317744;29331515;29393594;29557506;29632046;29632711;29786170;30429286;30573663;30755481;30833945;31154438;31611695;31844290;31848261;32157095;32161166;32350084;32387766;32938616;33592498;33912179;33968037;34087483;34357683;34433824;34561969;35051231;35154160;35318648;35580925;36215666;36241641;36284347;36670142;37419216;37938771;38184712;39062570;7613023;7983023;8041788;8695634;9207117;9464519;9642100;9790986",
        "class_list": "",
        "function": "DMT1 differentially regulates mitochondrial complex activities to reduce glutathione loss and mitigate ferroptosis., [RefSeq, PubMed]; DMT1-dependent endosome-mitochondria interactions regulate mitochondrial iron translocation and metastatic outgrowth., [RefSeq, PubMed]; Iron regulation of DMT1 involves the expression of a previously unrecognized upstream 5' exon (exon 1A) of the human and murine DMT1 gene, [RefSeq, PubMed]; Ischemic Neuroprotection by Insulin with Down-Regulation of Divalent Metal Transporter 1 (DMT1) Expression and Ferrous Iron-Dependent Cell Death. Publication Status: Online-Only, [RefSeq, PubMed]; Proton-coupled metal ion symporter operating with a proton to metal ion stoichiometry of 1:1 (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704, PubMed:25491917). Selectively transports various divalent metal cations, in decreasing affinity: Cd(2+) > Fe(2+) > Co(2+), Mn(2+) >> Zn(2+), Ni(2+), VO(2+) (PubMed:17109629, PubMed:17293870, PubMed:22736759, PubMed:25326704, PubMed:25491917). Essential for maintenance of iron homeostasis by modulating intestinal absorption of dietary Fe(2+) and TF-associated endosomal Fe(2+) transport in erythroid precursors and other cells (By similarity). Enables Fe(2+) and Mn(2+) ion entry into mitochondria, and is thus expected to promote mitochondrial heme synthesis, iron-sulfur cluster biogenesis and antioxidant defense (By similarity) (PubMed:24448823). Can mediate uncoupled fluxes of either protons or metal ions., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]; SLC11A2: a promising biomarker and therapeutic target in ovarian cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the solute carrier family 11 protein family. The product of this gene transports divalent metals and is involved in iron absorption. Mutations in this gene are associated with hypochromic microcytic anemia with iron overload. A related solute carrier family 11 protein gene is located on chromosome 2. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Apr 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 11,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KT08;B4DK84;F5H741;O43288;O60932;O94801;Q498Z5;Q8IUD7;Q96J35",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005385 zinc ion transmembrane transporter activity;GO:0046870 cadmium ion binding;GO:0022857 transmembrane transporter activity;GO:0015295 solute:proton symporter activity;GO:0005375 copper ion transmembrane transporter activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005769 early endosome",
        "go_biological_process": "GO:0034755 iron ion transmembrane transport;GO:0001666 response to hypoxia;GO:0006879 intracellular iron ion homeostasis;GO:0034599 cellular response to oxidative stress;GO:0010039 response to iron ion",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "P49281-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q49AM1-1",
        "uniprot_id": [
            {
                "id": "MTEF2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q49AM1",
                "type": "external"
            }
        ],
        "mass": 44414.0,
        "length": 385,
        "protein_name": "Transcription termination factor 2, mitochondrial",
        "gene_name": "MTERF2",
        "organism": "Human",
        "refseq_name": "transcription termination factor 2, mitochondrial precursor",
        "refseq_ac": [
            {
                "id": "NP_001028222",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028222",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MTERF2; MTERFD3",
        "gene_names_refseq": "MTERF2; MTERFD3; mTERFL",
        "protein_names_uniprotkb": "Transcription termination factor 2, mitochondrial; Mitochondrial transcription termination factor 2; Mitochondrial transcription termination factor-like protein; mTERF domain-containing protein 3, mitochondrial; mTERF-like; mTERF2; mTERFL",
        "protein_names_refseq": "MTERF domain containing 3; mTERF domain-containing protein 3, mitochondrial; mTERF-like; mitochondrial transcription termination factor-like protein; transcription termination factor 2, mitochondrial precursor; transcription termination factor 2, mitochondrial",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80298)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "11237011;16226716;19366608;20430012;20577816;21558281;26826381;26992070;27920218;28228285;29242379;29557506;30429286;30484775;31844290;31848261;32157095;32502341;33936100;34357683;35051231;36215666;36241641",
        "class_list": "",
        "function": "Binds mitochondrial DNA and plays a role in the regulation of transcription of mitochondrial mRNA and rRNA species., [UniProtKB, PubMed, PubMed, PubMed]; MTERF-domain of human MTERF3 forms a half-doughnut-shaped right-handed superhelix., [RefSeq, PubMed]; MTERFD1 and MTERFD3 have a role in impairing the completion of mitochondrial DNA replication, [RefSeq, PubMed]; MTERFL is a novel mTERF family member and a serum-inhibitory factor probably participating in the regulation of cell growth, [RefSeq, PubMed]; These findings demonstrate that MTERF2 contributes to MPP(+)-induced mitochondrial disruption and cell damage., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53HM2;Q9H4L6;Q9H7Y9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid",
        "go_biological_process": "GO:0006393 termination of mitochondrial transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q49AM1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z401-1",
        "uniprot_id": [
            {
                "id": "MYCPP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z401",
                "type": "external"
            }
        ],
        "mass": 209244.0,
        "length": 1863,
        "protein_name": "C-myc promoter-binding protein",
        "gene_name": "DENND4A",
        "organism": "Human",
        "refseq_name": "C-myc promoter-binding protein isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001138295",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138295",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "DENND4A; IRLB; MYCPBP",
        "gene_names_refseq": "DENND4A; IRLB; MYCPBP",
        "protein_names_uniprotkb": "C-myc promoter-binding protein; DENN domain-containing protein 4A",
        "protein_names_refseq": "C-myc promoter-binding protein isoform 1; DENN domain-containing protein 4A; DENN/MADD domain containing 4A; c-myc promoter binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10260);  (R-HSA-8876198)",
        "pathway_count": 2,
        "publication_count": 274,
        "publication_id_list": "10.1101/2023.09.13.557529;10818110;10990452;11038176;11179213;11237011;11516400;11689439;11703925;11746448;11784320;11917121;12058051;12221131;12244319;12364329;12427552;12475894;12684051;12906859;12944476;12972505;15096524;15138286;1516130;15247254;15388334;15528189;15561770;15692570;15878329;15914536;15958533;16207721;16373702;16410077;16525024;16525121;16571673;16641372;16754960;16880209;16950109;17043139;17081983;17132146;17189207;17208202;17239822;17287728;17488286;17562788;17574030;17646400;17671165;17678623;18076383;18094055;18220336;18354496;18367545;18446792;1845915;18477474;18559336;18585354;18664496;18669648;18701652;18767875;18779367;18804435;1900457;19109890;19345684;19403694;19413330;19490898;19620288;19651622;19656848;19690332;19725050;19729655;19745841;20008558;20058876;20068231;20154091;20159109;20159556;20166139;20305638;20308558;20404108;20434987;20592283;20797862;20851765;20937701;21041651;2115402;21183348;21187289;21216617;21273506;21330364;21421921;21445324;21458671;21532587;21554507;21586568;21683469;21706022;21718402;21776405;21951725;22013193;22065758;22072793;22171327;22365832;22433857;22511774;22581368;22595670;22622570;22648168;22653444;22705394;22762500;22908308;22983554;23084991;23091056;23147242;23176487;23176493;23186163;23220125;23239882;23247405;23263280;23295650;23333653;23351085;23357852;23378591;23420520;23444368;23478338;23481700;23645161;23678941;23684622;23713133;23839779;24296415;24644286;24694596;24715725;24719330;24891604;24917561;24967941;25074980;25341920;25343031;25418920;25472813;25505266;25576301;25645385;25648148;25713415;25880248;25925668;26055712;26154972;26177209;26245486;26375851;26434594;26538022;26811146;26925400;26936971;26992070;27041585;27044746;27103185;27246931;27329675;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28352266;28411811;28446606;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30379171;30410026;30429286;30524438;30779550;31092671;31154438;31217245;31530632;31844290;31848261;31937595;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33691108;33912179;33936100;33968037;34087483;34211107;34357683;34405274;34509645;34932366;35051231;35494241;35561310;35580925;36010968;36241641;36284347;37938771;7688123;7911226;8056341;8144603;8408203;8522602;8863739;9020086;9020161;9030515;9136770;9323142;9590177;9733780",
        "class_list": "",
        "function": "Probable guanine nucleotide exchange factor (GEF) which may activate RAB10. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form. According to PubMed:8056341, it may bind to ISRE-like element (interferon-stimulated response element) of MYC P2 promoter., [UniProtKB, PubMed, PubMed]; This gene encodes a DENN domain-containing protein that may function as a guanine nucleotide exchange factor that specifically activates ras-related protein Rab-10. This protein also contains a interferon stimulated response element-binding domain and may be involved in regulating the v-myc avian myelocytomatosis viral (MYC) oncogene. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 8. [provided by RefSeq, Mar 2016]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
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        "total_n_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 27,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 46,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E7EPL3;Q14655;Q86T77;Q8IVX2;Q8NB93",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0000813 ESCRT I complex",
        "go_biological_process": "GO:0032483 regulation of Rab protein signal transduction;GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 27.9,
        "record_id": "Q7Z401-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6IPT4-1",
        "uniprot_id": [
            {
                "id": "NB5R5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6IPT4",
                "type": "external"
            }
        ],
        "mass": 35892.0,
        "length": 315,
        "protein_name": "NADH-cytochrome b5 reductase-like",
        "gene_name": "CYB5RL",
        "organism": "Human",
        "refseq_name": "NADH-cytochrome b5 reductase-like isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001026842",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001026842",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CYB5RL",
        "gene_names_refseq": "CYB5RL",
        "protein_names_uniprotkb": "NADH-cytochrome b5 reductase-like; 1.6.2.2",
        "protein_names_refseq": "NADH-cytochrome b5 reductase-like isoform 1; NADH-cytochrome b5 reductase-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:606495);  (R-HSA-1237044)",
        "pathway_count": 2,
        "publication_count": 57,
        "publication_id_list": "10090333;10529219;10611283;11237011;11606574;12754312;12933803;1311094;1395;14958;15131110;15501038;1554744;15858218;16563834;16992238;16994616;17012249;17712059;17990881;19273840;19668749;20162361;20230836;21041929;2111324;234739;25937211;26375851;28218747;28904123;29393594;29437277;30524438;3080418;3136125;31844290;32157095;32357974;32387766;36010968;4514311;4647257;4975618;4994926;5656372;6407977;6433979;6819139;8070313;8300612;8875343;8972395;9054574;9143858;9336012;9486145",
        "class_list": "",
        "function": "Putative NADH-cytochrome b5 reductases family protein. May participate in fatty acid desaturation and elongation, cholesterol biosynthesis, drug metabolism, and, in erythrocyte, methemoglobin reduction., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "reported_snv": 3,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZBS4;Q8NF25",
        "ec_number_list": [
            {
                "id": "1.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016491 oxidoreductase activity;GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0090524 cytochrome-b5 reductase activity, acting on NADH",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0015701 bicarbonate transport",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "Q6IPT4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9ULH7-1",
        "uniprot_id": [
            {
                "id": "MRTFB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9ULH7",
                "type": "external"
            }
        ],
        "mass": 118127.0,
        "length": 1088,
        "protein_name": "Myocardin-related transcription factor B",
        "gene_name": "MRTFB",
        "organism": "Human",
        "refseq_name": "myocardin-related transcription factor B isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001295071",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295071",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MRTFB; KIAA1243; MKL2",
        "gene_names_refseq": "MKL2; MRTF-B; MRTFB; NPD001",
        "protein_names_uniprotkb": "Myocardin-related transcription factor B; MKL/myocardin-like protein 2; MRTF-B; Megakaryoblastic leukemia 2",
        "protein_names_refseq": "CTA-276F8.1; MKL and myocardin family member 2; MKL/myocardin like 2; MKL/myocardin-like protein 2; MKL1/myocardin like 2; megakaryoblastic leukemia 2; myocardin-related transcription factor B isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57496)",
        "pathway_count": 1,
        "publication_count": 97,
        "publication_id_list": "11237011;14565952;17947237;18056415;18669648;20068231;20220067;20607705;21248752;23186163;23301498;23481700;25114211;25576301;25645385;26154972;26992070;27543614;27600516;27846572;27862975;28063628;28228285;28314751;28657654;28832583;28834231;28860189;28904123;29242379;29331515;29393594;29557506;29632711;29786170;29789417;30315122;30379171;30429286;30524438;30620550;31092671;31154438;31492838;31844290;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32502341;32897882;32938616;32938750;32983136;33141586;33214551;33298915;33392160;33592498;33691108;33717175;33968037;33981976;34019948;34087483;34171305;34509645;34725712;34932366;35051231;35132862;35138101;35216178;35251023;35254053;35289036;35318648;35561310;35580925;35705054;36010968;36215666;36241641;37013900;37164693;37217939;37340703;37938771;38253038;38582447;38665916;38838015;39531497;40307207",
        "class_list": "",
        "function": "Acts as a transcriptional coactivator of serum response factor (SRF). Required for skeletal myogenic differentiation., [UniProtKB, PubMed]; BMP signaling modulates VSMC phenotype via cross-talk with the RhoA/MRTFs pathway, and may contribute to the development of the pathological characteristics observed in patients with PAH and other obliterative vascular diseases., [RefSeq, PubMed]; De novo variants in MRTFB have gain-of-function activity in Drosophila and are associated with a novel neurodevelopmental phenotype with dysmorphic features., [RefSeq, PubMed]; Dominant negative MKL2 blocked differentiation-induced expression of SRF target genes skeletal alpha-actin and alpha-myosin heavy chain and blocked differentiation of the myoblasts to myotubes in vitro., [RefSeq, PubMed]; KLF15 maintains contractile phenotype of vascular smooth muscle cells and prevents thoracic aortic dissection by interacting with MRTFB., [RefSeq, PubMed]; Myocardin-related transcription factors are critical mediators of transforming growth factor beta (TGF-beta) 1-induced epithelial-mesenchymal transition.[, [RefSeq, PubMed]; Oxidative Stress Enhances the TGF-beta2-RhoA-MRTF-A/B Axis in Cells Entering Endothelial-Mesenchymal Transition. Publication Status: Online-Only, [RefSeq, PubMed]; Role of CRP2-MRTF interaction in functions of myofibroblasts., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 11,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 11,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 11,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6ND53;B4DGT8;Q68CT1;Q6UB16;Q86WW2;Q8N226",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003713 transcription coactivator activity;GO:0045296 cadherin binding;GO:0003779 actin binding;GO:0004864 protein phosphatase inhibitor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0098794 postsynapse",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development;GO:0051145 smooth muscle cell differentiation;GO:1902895 positive regulation of miRNA transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 11.0,
        "record_id": "Q9ULH7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P13056-1",
        "uniprot_id": [
            {
                "id": "NR2C1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P13056",
                "type": "external"
            }
        ],
        "mass": 67315.0,
        "length": 603,
        "protein_name": "Nuclear receptor subfamily 2 group C member 1",
        "gene_name": "NR2C1",
        "organism": "Human",
        "refseq_name": "nuclear receptor subfamily 2 group C member 1 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001027458",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001027458",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NR2C1; TR2",
        "gene_names_refseq": "NR2C1; TR2",
        "protein_names_uniprotkb": "Nuclear receptor subfamily 2 group C member 1; Orphan nuclear receptor TR2; Testicular receptor 2",
        "protein_names_refseq": "TR2 nuclear hormone receptor; nuclear receptor subfamily 2 group C member 1 isoform b; orphan nuclear receptor TR2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7181);  (R-HSA-383280);  (R-HSA-4090294)",
        "pathway_count": 3,
        "publication_count": 84,
        "publication_id_list": "10235266;10542397;11121022;11237011;11865025;12077349;12093804;12144530;12177000;14500761;15175151;15192080;15192092;15896744;15923626;15961505;16751179;16912044;17010934;17020914;17105732;17218271;17314004;17717077;18452278;18669648;19041634;19211567;19692572;19850744;19864602;19955185;20068231;20159957;20719936;21467194;22424782;22544926;22930759;23186163;23481700;23546875;24715725;25114211;25576301;2597158;26154972;26992070;28228285;28834231;28904123;29493099;30315122;30379171;30429286;31154438;31844290;31848261;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33912179;33936100;33968037;34171305;3421977;34405274;34509645;34932366;35051231;35580925;36010968;36284347;36591938;37938771;40596516;9653119",
        "class_list": "",
        "function": "NamiRNA-enhancer network of miR-492 activates the NR2C1-TGF-beta/Smad3 pathway to promote epithelial-mesenchymal transition of pancreatic cancer., [RefSeq, PubMed]; Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Also activator of OCT4 gene expression. May be involved in stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation., [UniProtKB, PubMed, PubMed]; This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5K4;Q15625;Q15626",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding;GO:0003707 nuclear steroid receptor activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016605 PML body;GO:0000785 chromatin",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0048386 positive regulation of retinoic acid receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 8.8,
        "record_id": "P13056-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WU39-1",
        "uniprot_id": [
            {
                "id": "MZB1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WU39",
                "type": "external"
            }
        ],
        "mass": 20694.0,
        "length": 189,
        "protein_name": "Marginal zone B- and B1-cell-specific protein",
        "gene_name": "MZB1",
        "organism": "Human",
        "refseq_name": "marginal zone B- and B1-cell-specific protein precursor",
        "refseq_ac": [
            {
                "id": "NP_057543",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057543",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MZB1; HSPC190; MEDA7; PACAP",
        "gene_names_refseq": "MEDA-7; MZB1; PACAP; pERp1",
        "protein_names_uniprotkb": "Marginal zone B- and B1-cell-specific protein; MEDA-7; Mesenteric estrogen-dependent adipose 7; Plasma cell-induced resident ER protein; Plasma cell-induced resident endoplasmic reticulum protein; Proapoptotic caspase adapter protein; pERp1",
        "protein_names_refseq": "HSPC190; caspase-2 binding protein; marginal zone B- and B1-cell-specific protein precursor; mesenteric estrogen-dependent adipose 7; mesenteric oestrogen-dependent adipose gene- 7; plasma cell-induced ER protein 1; plasma cell-induced resident ER protein; plasma cell-induced resident endoplasmic reticulum protein; proapoptotic caspase adapter protein; proapoptotic caspase adaptor protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51237)",
        "pathway_count": 1,
        "publication_count": 43,
        "publication_id_list": "11237011;11350957;12792799;19805157;21688198;22661428;24714562;25418920;25502872;26154972;26375851;26728094;26811146;26992070;27862975;28467828;28832583;28834231;28904123;29242379;29393594;29508533;29557506;29632046;29786170;31530632;31844290;31998317;32265295;32350084;32897882;32983136;33453188;33912179;34078123;34433824;34932366;35154160;35653494;37332260;37852603;38508349;40307207",
        "class_list": "",
        "function": "Acts as a hormone-regulated adipokine/pro-inflammatory cytokine that is implicated in causing chronic inflammation, affecting cellular expansion and blunting insulin response in adipocytes. May have a role in the onset of insulin resistance., [UniProtKB]; Altered expression of MZB1 in periodontitis: A possible link to disease pathogenesis., [RefSeq, PubMed]; Associates with immunoglobulin M (IgM) heavy and light chains and promotes IgM assembly and secretion. May exert its effect by acting as a molecular chaperone or as an oxidoreductase as it displays a low level of oxidoreductase activity (By similarity). Isoform 2 may be involved in regulation of apoptosis. Helps to diversify peripheral B-cell functions by regulating Ca(2+) stores, antibody secretion and integrin activation., [UniProtKB, PubMed, PubMed]; High-resolution Crystal Structure of Human pERp1, A Saposin-like Protein Involved in IgA, IgM and Integrin Maturation in the Endoplasmic Reticulum., [RefSeq, PubMed]; MGC29506 gene, frequently down-regulated in intestinal-type gastric cancer, was found to encode secreted-type protein with six conserved cysteine residues [MGC29506], [RefSeq, PubMed]; MZB1 regulates cellular proliferation, mitochondrial dysfunction, and inflammation and targets the PI3K-Akt signaling pathway in acute pancreatitis., [RefSeq, PubMed]; MZB1 targeted by miR-185-5p inhibits the migration of human periodontal ligament cells through NF-kappaB signaling and promotes alveolar bone loss., [RefSeq, PubMed]; MZB1-expressing cells are essential for local immunoglobulin production in chronic rhinosinusitis with nasal polyps., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D2IYS0;Q7Z6N2;Q96RL5;Q9P0T3",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0008284 positive regulation of cell population proliferation;GO:0042127 regulation of cell population proliferation;GO:0006915 apoptotic process;GO:0030888 regulation of B cell proliferation;GO:0033622 integrin activation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q8WU39-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96DY7-1",
        "uniprot_id": [
            {
                "id": "MTBP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96DY7",
                "type": "external"
            }
        ],
        "mass": 102193.0,
        "length": 904,
        "protein_name": "Mdm2-binding protein",
        "gene_name": "MTBP",
        "organism": "Human",
        "refseq_name": "mdm2-binding protein",
        "refseq_ac": [
            {
                "id": "NP_071328",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071328",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MTBP",
        "gene_names_refseq": "MDM2BP; MTBP",
        "protein_names_uniprotkb": "Mdm2-binding protein; hMTBP",
        "protein_names_refseq": "MDM2 (mouse double minute 2)-binding protein, 104kD; Mdm2, transformed 3T3 cell double minute 2, p53 binding protein binding protein, 104kDa; mdm2-binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27085);  (R-HSA-9766229)",
        "pathway_count": 2,
        "publication_count": 65,
        "publication_id_list": "10906133;11237011;14517306;15632057;18669648;19413330;19664994;19664995;19690332;20068231;21274008;23186163;24866769;25253721;25576301;25759210;25880248;25892735;26280083;26758079;26992070;27846572;27920218;28228285;28514659;28649982;28832583;28904123;29242379;29356040;29393594;29493099;29557506;29769354;29789417;30379171;30524438;31530632;31844290;32157095;32265295;32357974;32387766;32502341;32897882;32938616;32966791;33141586;33298915;33592498;33608586;33717175;33912179;33936100;33968037;33981976;34171305;34509645;34561969;35051231;35318648;35580925;36010968;36241641;37217939",
        "class_list": "",
        "function": "Binding of the Treslin-MTBP Complex to Specific Regions of the Human Genome Promotes the Initiation of DNA Replication., [RefSeq, PubMed]; Data show that MTBP aggravates the invasion and metastasis of HCC by promoting the MDM2-mediated degradation of E-cadherin., [RefSeq, PubMed]; Data suggest that MTBP differentially regulates the activity of MDM2 towards two of its most critical targets (itself and p53) and in doing so significantly contributes to MDM2-dependent p53 homeostasis in unstressed cells. GeneRIF: MTBP contributes to MDM2 activity and through this to negative regulation of p53, [RefSeq, PubMed]; Identification and characterization of mouse Mdm2 binding protein, [RefSeq, PubMed]; Inhibits cell migration in vitro and suppresses the invasive behavior of tumor cells (By similarity). May play a role in MDM2-dependent p53/TP53 homeostasis in unstressed cells. Inhibits autoubiquitination of MDM2, thereby enhancing MDM2 stability. This promotes MDM2-mediated ubiquitination of p53/TP53 and its subsequent degradation., [UniProtKB, PubMed]; MTBP has an important role in recruiting and/or retaining the Mad1/Mad2 complex at the kinetochores during prometaphase, but its degradation is required for silencing the mitotic checkpoint., [RefSeq, PubMed]; MTBP significantly contributes to breast cancer survival and is a potential novel therapeutic target in Triple-negative breast cancer ., [RefSeq, PubMed]; Overexpression of MTBP resulted in the suppression of the migratory and metastatic potential of Hepatocellular carcinoma cells, while its downregulation increased the migration., [RefSeq, PubMed]; This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DUR5;Q9HA89",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0000776 kinetochore;GO:0000785 chromatin",
        "go_biological_process": "GO:0007089 traversing start control point of mitotic cell cycle;GO:0034501 protein localization to kinetochore;GO:0031396 regulation of protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "Q96DY7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z6M4-1",
        "uniprot_id": [
            {
                "id": "MTEF4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z6M4",
                "type": "external"
            }
        ],
        "mass": 43958.0,
        "length": 381,
        "protein_name": "Transcription termination factor 4, mitochondrial",
        "gene_name": "MTERF4",
        "organism": "Human",
        "refseq_name": "transcription termination factor 4, mitochondrial isoform 1",
        "refseq_ac": [
            {
                "id": "NP_872307",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_872307",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MTERF4; HSPC096; MTERFD2",
        "gene_names_refseq": "MTERF4; MTERFD2",
        "protein_names_uniprotkb": "Transcription termination factor 4, mitochondrial; Mitochondrial transcription termination factor 4; mTERF domain-containing protein 2",
        "protein_names_refseq": "MTERF domain-containing protein 2; transcription termination factor 4, mitochondrial isoform 1; transcription termination factor 4, mitochondrial",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:130916);  (R-HSA-6793080)",
        "pathway_count": 2,
        "publication_count": 30,
        "publication_id_list": "11237011;11809803;12496758;15110318;19356719;19417006;21531335;22341444;22949673;23022348;23303773;23804760;24036117;25009282;25074936;26464487;27667664;27894840;27974379;28082677;28904123;29242379;31844290;32357974;32938616;32983136;33592498;33912179;33936100;33981976",
        "class_list": "",
        "function": "Analysis of the 3D crystal structure of the human MTERF4-NSUN4 complex, [RefSeq, PubMed]; Regulator of mitochondrial ribosome biogenesis and translation. Binds to mitochondrial ribosomal RNAs 16S, 12S and 7S and targets NSUN4 RNA methyltransferase to the mitochondrial large ribosomal subunit (39S)., [UniProtKB, PubMed]; The overexpression of MTERF4 induced a significant increase in the levels of APP protein and secreted Abeta 42 in HEK293-APPswe cells compared with control cells these results suggest that MTERF4 promotes the amyloidogenic processing of APP by inhibiting ADAM10 in HEK293-APPswe cells; therefore, MTERF4 may play an important role in the pathogenesis of Alzheimer's disease., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6K0;Q9P0E0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019843 rRNA binding;GO:0140517 protein-RNA adaptor activity;GO:0140691 RNA folding chaperone;GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006364 rRNA processing;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0061668 mitochondrial ribosome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q7Z6M4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H3P2-1",
        "uniprot_id": [
            {
                "id": "NELFA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H3P2",
                "type": "external"
            }
        ],
        "mass": 57277.0,
        "length": 528,
        "protein_name": "Negative elongation factor A",
        "gene_name": "NELFA",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "NELFA; OKcl.15; WHSC2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Negative elongation factor A; NELF-A; Wolf-Hirschhorn syndrome candidate 2 protein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7469);  (R-HSA-112382);  (R-HSA-113418);  (R-HSA-167152);  (R-HSA-167158);  (R-HSA-167200);  (R-HSA-167238);  (R-HSA-167242);  (R-HSA-167243);  (R-HSA-167246);  (R-HSA-167287);  (R-HSA-167290);  (R-HSA-674695);  (R-HSA-6796648);  (R-HSA-75955)",
        "pathway_count": 15,
        "publication_count": 151,
        "publication_id_list": "10199401;10409432;10757782;10866664;10916156;10984493;11150502;11237011;11280764;11313498;11313499;11350971;11387440;11859374;11884399;11971958;11988847;12370301;12563561;12612062;12653964;12676794;14701750;14720331;15129427;15302935;15489290;15781865;16964243;17234882;18669648;1939271;19689476;19690332;19952111;20068231;20128819;20159561;21932426;22012619;22424782;22988298;23186163;23481700;23538671;23884411;24275569;24354960;2449431;24554720;24662513;24715725;24992895;25429106;25561469;25576301;25645385;25662406;25712099;25810538;26154972;26212219;26659056;26811146;26992070;27549314;27600516;27703488;27846572;28063628;28178396;28188670;28218747;28228285;2825027;28416261;28510447;28622427;28832583;28834231;28860189;28904123;29242379;29393594;29437277;29485866;29493099;29508533;29557506;29632046;29632711;29786170;29938870;30315122;30410026;30484775;30524438;31154438;31844290;31848261;31998317;32119511;32157095;32236612;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33437477;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34211107;34509645;35051231;35138101;35580925;36010968;36215666;36241641;37340703;37938771;38665916;39302247;40136647;40596516;41350704;7660122;7660129;7660130;7853496;8370526;9063748;9450929;9489704;9765293;9857195",
        "class_list": "",
        "function": "(Microbial infection) The NELF complex is involved in HIV-1 latency possibly involving recruitment of PCF11 to paused RNA polymerase II., [UniProtKB, PubMed]; Essential component of the NELF complex, a complex that negatively regulates the elongation of transcription by RNA polymerase II. The NELF complex, which acts via an association with the DSIF complex and causes transcriptional pausing, is counteracted by the P-TEFb kinase complex., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 6,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
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        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A2T1;O95392",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003682 chromatin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0032021 NELF complex",
        "go_biological_process": "GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0034244 negative regulation of transcription elongation by RNA polymerase II;GO:0160239 transcription pausing by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 15.9,
        "record_id": "Q9H3P2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43674-1",
        "uniprot_id": [
            {
                "id": "NDUB5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43674",
                "type": "external"
            }
        ],
        "mass": 21750.0,
        "length": 189,
        "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial",
        "gene_name": "NDUFB5",
        "organism": "Human",
        "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001186886",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186886",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NDUFB5",
        "gene_names_refseq": "CISGDH; NDUFB5; SGDH",
        "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial; CI-SGDH; Complex I-SGDH; NADH-ubiquinone oxidoreductase SGDH subunit",
        "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 5, 16kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 5, mitochondrial isoform 2; NADH-ubiquinone oxidoreductase SGDH subunit; complex I SGDH subunit; complex I-SGDH",
        "tax_id": 9606,
        "disease": "acute myocardial infarction (Disease Ontology:DOID:9408)",
        "pathway": " (hsa:4711);  (R-HSA-611105);  (R-HSA-6799198)",
        "pathway_count": 3,
        "publication_count": 124,
        "publication_id_list": "10.1074/mcp.M114.046862;10327278;11220739;11237011;11695836;12231006;12611891;12837546;1327877;14741580;15250827;16230336;17033964;17601350;17936786;186667;18977241;19752196;20406883;20552642;20858599;21924235;22645359;22869377;23150584;23270816;23481700;23553477;23564345;23747254;239860;24191001;24715725;25418920;25469497;25505266;25564869;25576301;25645385;25678554;25813380;25892735;26154972;26811146;26929215;26992070;27499296;27600516;27626371;27846572;27920218;28063628;28228285;28510447;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30192525;30315122;30429286;30524438;30779550;30833945;31154438;31217245;31530632;31611695;31666358;31794266;31844290;31848261;31866046;32157095;32265295;32320651;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33633747;33717175;33879611;33882309;33912179;33936100;33968037;33981976;34171305;34211107;34357683;34405274;34509645;34561969;34932366;35051231;35251023;35333655;35580925;35614220;36010968;36241641;36284347;38199007;38982516;4288886;9425316;9571201;9878551",
        "class_list": "",
        "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data suggest that the hub genes NADH:ubiquinone oxidoreductase subunit B5 (NDUFB5), translocase of inner mitochondrial membrane domain containing 1 (TIMMDC1), and voltage-dependent anion channel 3 (VDAC3) might serve as potential biomarkers for diagnosis and/or therapeutic targets for precise treatment of septic cardiomyopathy (SC) ., [RefSeq, PubMed]; METTL3-mediated NDUFB5 m6A modification promotes cell migration and mitochondrial respiration to promote the wound healing of diabetic foot ulcer. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a subunit of the multisubunit NADH:ubiquinone oxidoreductase (complex I). Mammalian complex I is composed of 45 different subunits. It locates at the mitochondrial inner membrane. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. Three transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
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        "total_o_glycosites": 2,
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        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q561V6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I",
        "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration;GO:0022904 respiratory electron transport chain",
        "synthesized_glycan_count": 0,
        "hit_score": 12.9,
        "record_id": "O43674-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P08247-1",
        "uniprot_id": [
            {
                "id": "SYPH_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P08247",
                "type": "external"
            }
        ],
        "mass": 33845.0,
        "length": 313,
        "protein_name": "Synaptophysin",
        "gene_name": "SYP",
        "organism": "Human",
        "refseq_name": "synaptophysin",
        "refseq_ac": [
            {
                "id": "NP_003170",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003170",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SYP",
        "gene_names_refseq": "MRX96; MRXSYP; SYP; XLID96",
        "protein_names_uniprotkb": "Synaptophysin; Major synaptic vesicle protein p38",
        "protein_names_refseq": "major synaptic vesicle protein P38; synaptophysin",
        "tax_id": 9606,
        "disease": "non-syndromic X-linked intellectual disability 96 (Disease Ontology:DOID:0112035); Alzheimer's disease (Disease Ontology:DOID:10652); alcohol use disorder (Disease Ontology:DOID:1574)",
        "pathway": " (hsa:6855);  (R-HSA-9662360)",
        "pathway_count": 2,
        "publication_count": 24,
        "publication_id_list": "10025409;11163272;11237011;17296554;18662323;19377476;1975480;28218747;28669405;29242379;29437277;29557506;30078552;30484775;3120152;33912179;34310040;34320691;35051231;36401284;37133725;37938771;8838578;9344658",
        "class_list": "",
        "function": "Aberrant synaptophysin expression in classic Hodgkin lymphoma. Publication Status: Online-Only, [RefSeq, PubMed]; Association between genetic polymorphisms of synaptophysin (SYP) gene and attention deficit hyperactivity disorder in Korean subjects., [RefSeq, PubMed]; Possibly involved in structural functions as organizing other membrane components or in targeting the vesicles to the plasma membrane. Involved in the regulation of short-term and long-term synaptic plasticity (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Slowly progressive behavioral frontotemporal dementia syndrome in a family co-segregating the C9orf72 expansion and a Synaptophysin mutation., [RefSeq, PubMed]; The prognostic significance of neuroendocrine markers and somatostatin receptor 2 in hepatocellular carcinoma., [RefSeq, PubMed]; This gene encodes an integral membrane protein of small synaptic vesicles in brain and endocrine cells. The protein also binds cholesterol and is thought to direct targeting of vesicle-associated membrane protein 2 (synaptobrevin) to intracellular compartments. Mutations in this gene are associated with an X-linked form of cognitive disability. [provided by RefSeq, Jul 2017]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "disease_count": 3,
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        "secondary_ac_list": "B2R7L6;B7Z359;Q6P2F7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0015485 cholesterol binding;GO:0042169 SH2 domain binding",
        "go_cellular_component": "GO:0031594 neuromuscular junction;GO:0043195 terminal bouton;GO:0048471 perinuclear region of cytoplasm;GO:0048786 presynaptic active zone;GO:0043005 neuron projection",
        "go_biological_process": "GO:0048172 regulation of short-term neuronal synaptic plasticity;GO:0006897 endocytosis;GO:0048169 regulation of long-term neuronal synaptic plasticity;GO:0048499 synaptic vesicle membrane organization;GO:0048168 regulation of neuronal synaptic plasticity",
        "synthesized_glycan_count": 0,
        "hit_score": 2.5,
        "record_id": "P08247-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BPW8-1",
        "uniprot_id": [
            {
                "id": "NIPS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BPW8",
                "type": "external"
            }
        ],
        "mass": 33310.0,
        "length": 284,
        "protein_name": "Protein NipSnap homolog 1",
        "gene_name": "NIPSNAP1",
        "organism": "Human",
        "refseq_name": "protein NipSnap homolog 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001189431",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001189431",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NIPSNAP1",
        "gene_names_refseq": "NIPSNAP1",
        "protein_names_uniprotkb": "Protein NipSnap homolog 1; NipSnap1",
        "protein_names_refseq": "4-nitrophenylphosphatase domain and non-neuronal SNAP25-like 1; protein NipSnap homolog 1 isoform 2; protein NipSnap homolog 1",
        "tax_id": 9606,
        "disease": "Parkinson's disease (Disease Ontology:DOID:14330)",
        "pathway": " (hsa:8508)",
        "pathway_count": 1,
        "publication_count": 54,
        "publication_id_list": "11237011;18392847;18477386;19608861;20068231;20166139;22311985;23481700;24275569;24366607;24715725;25418920;25892735;26154972;26992070;27846572;27920218;28218747;28228285;28411811;28832583;28855257;28904123;29242379;29393594;29437277;29493099;29557506;29632046;29632711;29769354;30315122;30982665;31217245;31844290;31848261;32161166;32357974;32387766;32897882;32938616;33968037;34171305;34185709;34229054;34357683;34561969;35051231;36241641;36581221;36871154;37938771;38297121;9661659",
        "class_list": "",
        "function": "NIPSNAP1 and NIPSNAP2 have a redundant function in mitophagy and are predominantly expressed in different tissues., [RefSeq, PubMed]; NIPSNAP1 is an interacting molecule of NST and plays a crucial role in pain transmission., [RefSeq, PubMed]; Protein involved in mitophagy by facilitating recruitment of the autophagy machinery required for clearance of damaged mitochondria (PubMed:30982665). Accumulates on the mitochondria surface in response to mitochondrial depolarization and acts as a 'eat me' signal by recruiting proteins involved in selective autophagy, such as autophagy receptors (CALCOCO2/NDP52, NBR1, SQSTM1/p62, TAX1BP1 and WDFY3/ALFY) and ATG8 family proteins (MAP1LC3A, MAP1LC3B, MAP1LC3C, GABARAP, GABARAPL1 and GABARAPL2) (PubMed:30982665)., [UniProtKB, PubMed]; The Tumorigenic Effect of lncRNA AFAP1-AS1 is Mediated by Translated Peptide ATMLP Under the Control of m[6] A Methylation., [RefSeq, PubMed]; This gene encodes a member of the NipSnap family of proteins that may be involved in vesicular transport. A similar protein in mice inhibits the calcium channel TRPV6, and is also localized to the inner mitochondrial membrane where it may play a role in mitochondrial DNA maintenance. A pseudogene of this gene is located on the short arm of chromosome 17. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]., [RefSeq]; This study presents the first physiological function of mouse Nipsnap1 as an associated protein inhibiting transient receptor potential vanilloid channel 6 activity that possibly exerts its effect directly at the plasma membrane., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RAY3;O43800",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0097060 synaptic membrane",
        "go_biological_process": "GO:0019233 sensory perception of pain;GO:0000423 mitophagy",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "Q9BPW8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IUG5-1",
        "uniprot_id": [
            {
                "id": "MY18B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IUG5",
                "type": "external"
            }
        ],
        "mass": 285215.0,
        "length": 2567,
        "protein_name": "Unconventional myosin-XVIIIb",
        "gene_name": "MYO18B",
        "organism": "Human",
        "refseq_name": "unconventional myosin-XVIIIb isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001305174",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305174",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO18B",
        "gene_names_refseq": "KFS4; MYO18B",
        "protein_names_uniprotkb": "Unconventional myosin-XVIIIb",
        "protein_names_refseq": "myosin 18B; unconventional myosin-XVIIIb isoform 1; unconventional myosin-XVIIIb",
        "tax_id": 9606,
        "disease": "Klippel-Feil syndrome 4 (Disease Ontology:DOID:0080592)",
        "pathway": " (hsa:84700)",
        "pathway_count": 1,
        "publication_count": 35,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12209013;12547197;12741677;14654843;15305387;17081983;18088087;18477386;18669648;20068231;23186163;23481700;25748484;26768311;28832583;29557506;29786170;30379171;30390677;30581023;31154438;31217245;31844290;32161166;32387766;32502341;32877672;32983136;33179433;33555505;35051231;35254053;36010968",
        "class_list": "",
        "function": "Candidate tumor suppressor gene at chromosome 22q12.1, deleted, mutated, and methylated in human lung cancer, [RefSeq, PubMed]; Further delineation of MYO18B-related autosomal recessive Klippel-Feil syndrome with myopathy and facial dysmorphism., [RefSeq, PubMed]; Human MYO18B, a novel unconventional myosin heavy chain expressed in striated muscles moves into the myonuclei upon differentiation, [RefSeq, PubMed]; MYO18B alterations, including both epigenetic and genetic alterations, play an important role in ovarian carcinogenesis, [RefSeq, PubMed]; MYO18B promoted hepatocellular carcinoma growth and migration via the activation of PI3K/AKT/mTOR signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in intracellular trafficking of the muscle cell when in the cytoplasm, whereas entering the nucleus, may be involved in the regulation of muscle specific genes. May play a role in the control of tumor development and progression; restored MYO18B expression in lung cancer cells suppresses anchorage-independent growth., [UniProtKB]; Myosin-18B Regulates Higher-Order Organization of the Cardiac Sarcomere through Thin Filament Cross-Linking and Thick Filament Dynamics., [RefSeq, PubMed]; Myosin18B predicts favorable prognosis of cutaneous squamous-cell carcinoma., [RefSeq, PubMed]; The protein encoded by this gene may regulate muscle-specific genes when in the nucleus and may influence intracellular trafficking when in the cytoplasm. The encoded protein functions as a homodimer and may interact with F actin. Mutations in this gene are associated with lung cancer. [provided by RefSeq, Jul 2008]., [RefSeq]; The results reveal a critical role for myosin-18B in myosin II stack assembly and provide evidence that myosin II stacks are important for a variety of vital processes in cells., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 92,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A075B6F5;B2RWP3;F5GXR6;F5GYU7;Q8NDI8;Q8TE65;Q8WWS0;Q96KH2;Q96KR8;Q96KR9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0003774 cytoskeletal motor activity;GO:0003779 actin binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0032982 myosin filament;GO:0030018 Z disc",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q8IUG5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96FI4-1",
        "uniprot_id": [
            {
                "id": "NEIL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96FI4",
                "type": "external"
            }
        ],
        "mass": 43684.0,
        "length": 390,
        "protein_name": "Endonuclease 8-like 1",
        "gene_name": "NEIL1",
        "organism": "Human",
        "refseq_name": "endonuclease 8-like 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001243481",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243481",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NEIL1",
        "gene_names_refseq": "FPG1; NEI1; NEIL1; hFPG1",
        "protein_names_uniprotkb": "Endonuclease 8-like 1; 3.2.2.-; 4.2.99.18; DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; Endonuclease VIII-like 1; FPG1; NEH1; Nei homolog 1; Nei-like protein 1",
        "protein_names_refseq": "DNA endonuclease eight-like glycosylase 1; DNA glycosylase/AP lyase Neil1; DNA-(apurinic or apyrimidinic site) lyase Neil1; NEH1; endonuclease 8-like 1 isoform 1; endonuclease 8-like 1; endonuclease VIII-like 1; nei endonuclease VIII-like 1; nei homolog 1; nei-like protein 1",
        "tax_id": 9606,
        "disease": "abdominal obesity-metabolic syndrome (Disease Ontology:DOID:0060611); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:79661);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-5649702);  (R-HSA-9616334)",
        "pathway_count": 5,
        "publication_count": 51,
        "publication_id_list": "10074426;10882850;10930409;11056019;11163244;11237011;11904416;12097317;12140329;12200441;12433996;12456671;12509226;12718543;14522990;15232006;15260972;15319300;15341901;16221681;16982218;17389588;17556049;18491316;21068368;21697813;21722948;22569481;22848106;22962365;23595123;24382305;26095805;27354518;27518429;30524438;32938616;34226550;34932366;35051231;35190641;35917336;37517321;38795603;39894887;8218289;8407958;8662714;9705289;9811839;9890904",
        "class_list": "",
        "function": "DNA repair glycosylase hNEIL1 triages damaged bases via competing interaction modes. Publication Status: Online-Only, [RefSeq, PubMed]; Functional analyses of single nucleotide polymorphic variants of the DNA glycosylase NEIL1 in sub-Saharan African populations., [RefSeq, PubMed]; Functional characterization of single nucleotide polymorphic variants of DNA repair enzyme NEIL1 in South Asian populations., [RefSeq, PubMed]; HFPG1 and hFPG2 repair 8-oxoguanine and other DNA oxidation products. (hFPG1 and hFPG2), [RefSeq, PubMed]; Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as a DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized pyrimidines, such as thymine glycol, formamidopyrimidine (Fapy) and 5-hydroxyuracil. Has marginal activity towards 8-oxoguanine. Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates. Has DNA glycosylase/lyase activity towards mismatched uracil and thymine, in particular in U:C and T:C mismatches. Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; NEIL1 Recoding due to RNA Editing Impacts Lesion-Specific Recognition and Excision., [RefSeq, PubMed]; NEIL1 and NEIL2 are preferentially involved in repair of lesions in DNA bubbles generated during transcription and/or replication, [RefSeq, PubMed]; P53-NEIL1 co-abnormalities induce genomic instability and promote synthetic lethality with Chk1 inhibition in multiple myeloma having concomitant 17p13(del) and 1q21(gain)., [RefSeq, PubMed]; Pyrimidine dimer repair enzyme located on the long arm of chromosome 15 that is frequently deleted in human cancers., [RefSeq, PubMed]; This gene is a member of the Nei endonuclease VIII-like gene family which encodes DNA glycosylases. The encoded enzyme participates in the DNA repair pathway by initiating base excision repair by removing damaged bases, primarily oxidized pyrimidines. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DW75;Q6ZRA7;Q86XW7;Q9H6C3",
        "ec_number_list": [
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "3.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "4.2.99.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "6.5.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:6.5.1.1",
                "type": "external"
            },
            {
                "id": "1.14.11.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51",
                "type": "external"
            },
            {
                "id": "1.14.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-",
                "type": "external"
            },
            {
                "id": "1.14.11.33",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0019104 DNA N-glycosylase activity;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity;GO:0140078 class I DNA-(apurinic or apyrimidinic site) endonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0006287 base-excision repair, gap-filling;GO:0006284 base-excision repair;GO:0045008 depyrimidination",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q96FI4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P19429-1",
        "uniprot_id": [
            {
                "id": "TNNI3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P19429",
                "type": "external"
            }
        ],
        "mass": 24008.0,
        "length": 210,
        "protein_name": "Troponin I, cardiac muscle",
        "gene_name": "TNNI3",
        "organism": "Human",
        "refseq_name": "troponin I, cardiac muscle",
        "refseq_ac": [
            {
                "id": "NP_000354",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000354",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TNNI3; TNNC1",
        "gene_names_refseq": "CMD1FF; CMD2A; CMH7; RCM1; TNNC1; TNNI3; cTnI",
        "protein_names_uniprotkb": "Troponin I, cardiac muscle; Cardiac troponin I",
        "protein_names_refseq": "cardiomyopathy, dilated 2A (autosomal recessive); troponin I type 3 (cardiac); troponin I, cardiac muscle",
        "tax_id": 9606,
        "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); stroke (Disease Ontology:DOID:0051061); hypertrophic cardiomyopathy 7 (Disease Ontology:DOID:0110313); dilated cardiomyopathy 1FF (Disease Ontology:DOID:0110459); dilated cardiomyopathy 2A (Disease Ontology:DOID:0110460); familial restrictive cardiomyopathy 1 (Disease Ontology:DOID:0111425); heart disease (Disease Ontology:DOID:114); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); dilated cardiomyopathy (Disease Ontology:DOID:12930); adenocarcinoma (Disease Ontology:DOID:299); coronary artery disease (Disease Ontology:DOID:3393); restrictive cardiomyopathy (Disease Ontology:DOID:397)",
        "pathway": " (hsa:7137);  (R-HSA-390522);  (R-HSA-5578775)",
        "pathway_count": 3,
        "publication_count": 112,
        "publication_id_list": "10220561;10387074;10747208;10913253;11056032;11062458;11121119;11237011;11724573;11815426;11904166;11904675;12060657;12119109;12242269;12531876;12707239;12832055;12953268;12974739;1371824;14596793;15070570;15134451;15174025;15260953;15514163;15598648;15601779;15754088;15769444;16199542;16754674;1693919;17010989;17224452;17357072;17486119;17854829;18445579;18550549;18986304;18995841;19278978;1934363;19590045;19751721;20023122;20079745;20079747;20164197;20388710;21108950;21533915;21846512;21876643;21959857;22210847;2226790;2226863;22427649;22456184;22707725;22972900;23144315;23271734;23288486;23318976;23362265;23549614;23610579;24116014;2430951;24585778;24772522;2477373;25296321;2559024;25771144;2584239;25994790;26851561;27557662;27833092;2838329;28645727;2953725;30379171;32086378;32169400;32171076;32209382;32251612;32305557;32475810;32530509;32589600;32596365;38497452;38683127;38924380;39196031;6328127;7702581;7929371;8406024;8661099;8798450;8918259;9241277;9346285;9762417",
        "class_list": "",
        "function": "Cardiac troponin I directly binds and inhibits mitochondrial ATP synthase with a noncanonical role in the post-ischemic heart., [RefSeq, PubMed]; Decreased intranuclear cardiac troponin I impairs cardiac autophagy through FOS/ATG5 in ageing hearts., [RefSeq, PubMed]; Homozygous TNNI3 frameshift variant in a consanguineous family with lethal infantile dilated cardiomyopathy., [RefSeq, PubMed]; Impaired Relaxation in Induced Pluripotent Stem Cell-Derived Cardiomyocytes with Pathogenic TNNI3 Mutation of Pediatric Restrictive Cardiomyopathy., [RefSeq, PubMed]; Troponin I (TnI), along with troponin T (TnT) and troponin C (TnC), is one of 3 subunits that form the troponin complex of the thin filaments of striated muscle. TnI is the inhibitory subunit; blocking actin-myosin interactions and thereby mediating striated muscle relaxation. The TnI subfamily contains three genes: TnI-skeletal-fast-twitch, TnI-skeletal-slow-twitch, and TnI-cardiac. This gene encodes the TnI-cardiac protein and is exclusively expressed in cardiac muscle tissues. Mutations in this gene cause familial hypertrophic cardiomyopathy type 7 (CMH7) and familial restrictive cardiomyopathy (RCM). Troponin I is useful in making a diagnosis of heart failure, and of ischemic heart disease. An elevated level of troponin is also now used as indicator of acute myocardial injury in patients hospitalized with moderate/severe Coronavirus Disease 2019 (COVID-19). Such elevation has also been associated with higher risk of mortality in cardiovascular disease patients hospitalized due to COVID-19. [provided by RefSeq, Aug 2020]., [RefSeq]; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 46,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "monitoring",
        "glycan_count": 1,
        "disease_count": 12,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030172 troponin C binding;GO:0031014 troponin T binding;GO:0003779 actin binding;GO:0019901 protein kinase binding;GO:0019904 protein domain specific binding",
        "go_cellular_component": "GO:1990584 cardiac Troponin complex;GO:0005829 cytosol;GO:0030017 sarcomere;GO:0097512 cardiac myofibril;GO:0005861 troponin complex",
        "go_biological_process": "GO:0001980 regulation of systemic arterial blood pressure by ischemic conditions;GO:0001570 vasculogenesis;GO:0003009 skeletal muscle contraction;GO:0006940 regulation of smooth muscle contraction;GO:0007507 heart development",
        "synthesized_glycan_count": 0,
        "hit_score": 11.5,
        "record_id": "P19429-1",
        "record_type": "protein",
        "filter_code": "0100000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N1T3-1",
        "uniprot_id": [
            {
                "id": "MYO1H_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N1T3",
                "type": "external"
            }
        ],
        "mass": 119037.0,
        "length": 1032,
        "protein_name": "Unconventional myosin-Ih",
        "gene_name": "MYO1H",
        "organism": "Human",
        "refseq_name": "unconventional myosin-Ih isoform X2",
        "refseq_ac": [
            {
                "id": "XP_047284694",
                "url": "https://www.ncbi.nlm.nih.gov/protein/XP_047284694",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO1H",
        "gene_names_refseq": "CCHS2; MYO1H",
        "protein_names_uniprotkb": "Unconventional myosin-Ih; Myosin-1H",
        "protein_names_refseq": "unconventional myosin-Ih isoform X2",
        "tax_id": 9606,
        "disease": "congenital central hypoventilation syndrome (Disease Ontology:DOID:0060731); central hypoventilation syndrome, congenital, 2, and autonomic dysfunction (MONDO:MONDO:0030537)",
        "pathway": " (hsa:283446)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;23186163;24715725;28779001;28904123;29557506;31844290;32357974;32387766;32488085;33633747;33968037;34509645;35051231;35580925;36010968;36241641;36284347;37217939",
        "class_list": "",
        "function": "Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F5H3C6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003774 cytoskeletal motor activity;GO:0003779 actin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0005902 microvillus",
        "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030048 actin filament-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q8N1T3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UKN1-1",
        "uniprot_id": [
            {
                "id": "MUC12_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UKN1",
                "type": "external"
            }
        ],
        "mass": 558164.0,
        "length": 5478,
        "protein_name": "Mucin-12",
        "gene_name": "MUC12",
        "organism": "Human",
        "refseq_name": "mucin-12 precursor",
        "refseq_ac": [
            {
                "id": "NP_001157934",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157934",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MUC12; MUC11",
        "gene_names_refseq": "MUC-11; MUC-12; MUC11; MUC12",
        "protein_names_uniprotkb": "Mucin-12; MUC-11; MUC-12; Mucin-11",
        "protein_names_refseq": "mucin-11; mucin-12 precursor; mucin-12",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10071);  (R-HSA-5083625);  (R-HSA-5083632);  (R-HSA-5083636);  (R-HSA-5621480);  (R-HSA-913709);  (R-HSA-977068)",
        "pathway_count": 7,
        "publication_count": 80,
        "publication_id_list": "10330415;10430883;10463611;10504389;10742600;10753916;11042166;11062056;11110698;11237011;11283017;11304796;11341784;11606584;11821425;12464682;12855678;1329093;14656219;15466199;15486459;15560372;15599692;15620693;15687324;15943821;15953034;16151858;16251947;16319059;17050534;17058067;17113861;18490740;18537974;18776906;18818202;18834073;19617566;20162577;21880719;22041900;22183981;22461326;23053572;23507963;23602766;2373995;24643043;25153226;26770020;29237092;29242379;29557506;29789417;30481538;31154438;31844290;31848261;32488085;32596961;33968037;33981976;34087483;35051231;37332045;38253038;7655172;8333853;8598452;8611500;8920913;8972730;9042338;9295285;9394011;9417100;9435216;9915862;9988682",
        "class_list": "",
        "function": "Involved in epithelial cell protection, adhesion modulation, and signaling. May be involved in epithelial cell growth regulation. Stimulated by both cytokine TNF and TGF-beta in intestinal epithelium., [UniProtKB, PubMed]; Mucin12 is a protein that shows common antigenicity in both A. lumbricoides and its human host., [RefSeq, PubMed]; Multivariate analysis disclosed that MUC12 expression status was an independent prognostic factor in Stages II and III CRC (relative risk, 8.236; 95% confidence interval, 1.702-39.849 p = 0.009)., [RefSeq, PubMed]; Patients with active ulcerative colitis(UC) showed no significant expression of MUC12 gene in mucosa compared to the group of patients with UC in remission, [RefSeq, PubMed]; PiRNA-1742 promotes renal cell carcinoma malignancy by regulating USP8 stability through binding to hnRNPU and thereby inhibiting MUC12 ubiquitination., [RefSeq, PubMed]; Reflux laryngitis is associated with down-regulation of mucin gene expression., [RefSeq, PubMed]; The oncogenic role of MUC12 in RCC progression depends on c-Jun/TGF-beta signalling., [RefSeq, PubMed]; This gene encodes an integral membrane glycoprotein that is a member of the mucin family. Mucins are O-glycosylated proteins that play an essential role in forming protective mucous barriers on epithelial surfaces and have been implicated in epithelial renewal and differentiation. These glycoproteins also play a role in intracellular signaling. This protein is expressed on the apical membrane surface of epithelial cells that line the mucosal surfaces of many different tissues including the colon, pancreas, prostate, and uterus. The expression of this gene is downregulated in colorectal cancer tissue. [provided by RefSeq, Apr 2017]., [RefSeq]",
        "predicted_glycosites": 22,
        "predicted_n_glycosites": 14,
        "predicted_o_glycosites": 8,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 277,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 30,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6ND38;F5GWV9;Q9UKN0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005796 Golgi lumen;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0001558 regulation of cell growth",
        "synthesized_glycan_count": 0,
        "hit_score": 9.0,
        "record_id": "Q9UKN1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.000100.000000000001000000.0100000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P61916-1",
        "uniprot_id": [
            {
                "id": "NPC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P61916",
                "type": "external"
            }
        ],
        "mass": 16570.0,
        "length": 151,
        "protein_name": "NPC intracellular cholesterol transporter 2",
        "gene_name": "NPC2",
        "organism": "Human",
        "refseq_name": "NPC intracellular cholesterol transporter 2 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_006423",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006423",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NPC2; HE1",
        "gene_names_refseq": "EDDM1; HE1; NPC2",
        "protein_names_uniprotkb": "NPC intracellular cholesterol transporter 2; Epididymal secretory protein E1; He1; Human epididymis-specific protein 1; Niemann-Pick disease type C2 protein",
        "protein_names_refseq": "NPC intracellular cholesterol transporter 2 isoform 2 precursor; Niemann-Pick disease type C2 protein; epididymal protein 1; epididymis secretory sperm binding protein; human epididymis-specific protein 1; tissue-specific secretory protein",
        "tax_id": 9606,
        "disease": "Niemann-Pick disease type C2 (Disease Ontology:DOID:0070114); Niemann-Pick disease (Disease Ontology:DOID:14504)",
        "pathway": " (hsa:10577);  (R-HSA-6798695);  (R-HSA-8964038)",
        "pathway_count": 3,
        "publication_count": 119,
        "publication_id_list": "10.1101/2023.09.13.557529;10224102;10438503;11125141;11237011;11567215;11584272;12221107;12447927;12464675;12955717;15110773;15166224;15265030;15542393;15937921;16126423;16179341;16548883;17018531;1718995;17452316;18644789;18772377;18782767;18823126;18832164;19141679;19159218;19196236;19232397;19563754;19592704;19664597;19723497;20674853;20947831;21081667;21315718;21412152;22095670;221835;22764087;23090970;23650620;23783831;24868095;25418920;25502872;25645385;25699256;25915661;26154972;26474739;26811146;26929215;26992070;2722848;27238017;27452731;27551080;27600516;28228285;28467828;28832583;28904123;29242379;29393594;29557506;29580834;29632046;29632711;29741879;30429286;31844290;32157095;32162841;32265295;32350084;32387766;32938616;32983136;33043033;33123756;33592498;33866776;33936100;33968037;33981976;34087483;34171305;34420959;34433824;34445279;34509645;34685683;34725712;35051231;35154160;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37074911;37938771;38665916;39160329;8049197;8112342;8146180;8407899;8418812;8692836;9705237;9756920",
        "class_list": "",
        "function": "Intracellular cholesterol transporter which acts in concert with NPC1 and plays an important role in the egress of cholesterol from the lysosomal compartment (PubMed:11125141, PubMed:15937921, PubMed:17018531, PubMed:18772377, PubMed:29580834). Unesterified cholesterol that has been released from LDLs in the lumen of the late endosomes/lysosomes is transferred by NPC2 to the cholesterol-binding pocket in the N-terminal domain of NPC1 (PubMed:17018531, PubMed:18772377, PubMed:27238017). May bind and mobilize cholesterol that is associated with membranes (PubMed:18823126). NPC2 binds cholesterol with a 1:1 stoichiometry (PubMed:17018531). Can bind a variety of sterols, including lathosterol, desmosterol and the plant sterols stigmasterol and beta-sitosterol (PubMed:17018531). The secreted form of NCP2 regulates biliary cholesterol secretion via stimulation of ABCG5/ABCG8-mediated cholesterol transport (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Niemann-Pick Type C 1 (NPC1) and NPC2 Gene Variability in Demented Patients with Evidence of Brain Amyloid Deposition., [RefSeq, PubMed]; Secretory NPC2 Protein-Mediated Free Cholesterol Levels Were Correlated with the Sorafenib Response in Hepatocellular Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The role of NPC2 gene in glioma was investigated based on bioinformatics analysis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a protein containing a lipid recognition domain. The encoded protein may function in regulating the transport of cholesterol through the late endosomal/lysosomal system. Mutations in this gene have been associated with Niemann-Pick disease, type C2 and frontal lobe atrophy. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptomic Biomarkers for Tuberculosis: Validation of NPC2 as a Single mRNA Biomarker to Diagnose TB, Predict Disease Progression, and Monitor Treatment Response. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 2,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 33,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DQV7;Q15668;Q29413",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019899 enzyme binding;GO:0015485 cholesterol binding;GO:0120020 cholesterol transfer activity;GO:0032934 sterol binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0070062 extracellular exosome;GO:0005764 lysosome",
        "go_biological_process": "GO:0019747 regulation of isoprenoid metabolic process;GO:0032366 intracellular sterol transport;GO:0046836 glycolipid transport;GO:0008203 cholesterol metabolic process;GO:0009615 response to virus",
        "synthesized_glycan_count": 0,
        "hit_score": 15.7,
        "record_id": "P61916-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100100001000.111.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96H55-1",
        "uniprot_id": [
            {
                "id": "MYO19_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96H55",
                "type": "external"
            }
        ],
        "mass": 109135.0,
        "length": 970,
        "protein_name": "Unconventional myosin-XIX",
        "gene_name": "MYO19",
        "organism": "Human",
        "refseq_name": "unconventional myosin-XIX isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001028752",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028752",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO19; MYOHD1",
        "gene_names_refseq": "MYO19; MYOHD1",
        "protein_names_uniprotkb": "Unconventional myosin-XIX; Myosin head domain-containing protein 1",
        "protein_names_refseq": "myosin head domain containing 1; myosin head domain-containing protein 1; unconventional myosin-XIX isoform 3; unconventional myosin-XIX",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80179);  (R-HSA-9013419);  (R-HSA-9013425)",
        "pathway_count": 3,
        "publication_count": 67,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;16630562;19103291;19932026;23186163;23481700;23568824;24714562;25418920;25447992;25469497;25576301;25892735;26659663;26811146;26929215;26992070;27126804;27600516;27846572;27920218;28063628;28218747;28228285;28514659;28832583;28904123;28912602;29242379;29331515;29393594;29437277;29508533;29557506;29632046;29694881;29769354;30111583;30484775;30513825;30524438;31217245;31479585;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;33298915;33392160;33592498;33912179;33968037;33981976;34013964;34087483;34171305;34405274;35051231;35251023;35580925;36010968;36241641",
        "class_list": "",
        "function": "Actin-based motor molecule with ATPase activity that localizes to the mitochondrion outer membrane (PubMed:19932026, PubMed:23568824, PubMed:25447992). Motor protein that moves towards the plus-end of actin filaments (By similarity). Required for mitochondrial inheritance during mitosis (PubMed:25447992). May be involved in mitochondrial transport or positioning (PubMed:23568824)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Coordination of mitochondrial and cellular dynamics by the actin-based motor Myo19., [RefSeq, PubMed]; Miro1 binds directly to a C-terminal fragment of the Myo19 tail region and that Miro1/2 recruit the Myo19 tail. Publication Status: Online-Only, [RefSeq, PubMed]; Myo19 is a novel regulator of cell division., [RefSeq, PubMed]; Myo19 is a stably attached OMM molecular motor., [RefSeq, PubMed]; The MyMOMA domain of MYO19 encodes for distinct Miro-dependent and Miro-independent mechanisms of interaction with mitochondrial membranes., [RefSeq, PubMed]; These results suggest that this novel myosin functions as an actin-based motor for mitochondrial movement in vertebrate cells., [RefSeq, PubMed]; We provide a model explaining how Myo19 translocation may be regulated by the local ATP/ADP ratio, coupled to the mitochondria presence in the filopodia. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 9462,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q59GS4;Q9H5X2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0016887 ATP hydrolysis activity;GO:0032027 myosin light chain binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0015629 actin cytoskeleton",
        "go_biological_process": "GO:0090140 regulation of mitochondrial fission;GO:0034642 mitochondrion migration along actin filament;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0032465 regulation of cytokinesis",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q96H55-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.1000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95299-1",
        "uniprot_id": [
            {
                "id": "NDUAA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95299",
                "type": "external"
            }
        ],
        "mass": 40751.0,
        "length": 355,
        "protein_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial",
        "gene_name": "NDUFA10",
        "organism": "Human",
        "refseq_name": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_004535",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004535",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NDUFA10",
        "gene_names_refseq": "CI-42KD; CI-42k; MC1DN22; NDUFA10",
        "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; CI-42kD; Complex I-42kD; NADH-ubiquinone oxidoreductase 42 kDa subunit",
        "protein_names_refseq": "NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial isoform 1 precursor; NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial; NADH-ubiquinone oxidoreductase 42 kDa subunit; complex I 42kDa subunit",
        "tax_id": 9606,
        "disease": "nuclear type mitochondrial complex I deficiency 22 (Disease Ontology:DOID:0112069)",
        "pathway": " (hsa:4705);  (R-HSA-611105);  (R-HSA-6799198)",
        "pathway_count": 3,
        "publication_count": 79,
        "publication_id_list": "10327278;11220739;11237011;11695836;12231006;12611891;12837546;1327877;14741580;15250827;16230336;17033964;17936786;186667;19752196;20406883;20552642;20858599;21150889;21924235;23150584;23270816;23481700;23553477;23564345;23747254;239860;24191001;25564869;25678554;26741492;27499296;27626371;27893789;28228285;28832583;28834231;28904123;29493099;29557506;30315122;30524438;31666358;31844290;31848261;31866046;32157095;32161166;32320651;32357974;32938616;33043033;33141586;33298915;33592498;33691108;33717175;33879611;33882309;33912179;33968037;34124242;34357683;34561969;35051231;35154160;35333655;35580925;35614220;35739187;36010968;36581221;37373264;38199007;38665916;40914422;4288886;9571201;9878551",
        "class_list": "",
        "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; An Exploration of the Coherent Effects between METTL3 and NDUFA10 on Alzheimer's Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Identifying Mitochondrial-Related Genes NDUFA10 and NDUFV2 as Prognostic Markers for Prostate Cancer through Biclustering. Publication Status: Online-Only, [RefSeq, PubMed]; Most mitochondrial dGTP is tightly bound to respiratory complex I through the NDUFA10 subunit. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a component of 42 kDa complex I, the first enzyme complex in the electron transport chain of mitochondria. This protein has NADH dehydrogenase activity and oxidoreductase activity. It transfers electrons from NADH to the respiratory chain. A mutation in this gene was found in an individual with Leigh syndrome. [provided by RefSeq, Apr 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WXC9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix;GO:0045271 respiratory chain complex I",
        "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "O95299-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75425-1",
        "uniprot_id": [
            {
                "id": "MSPD3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75425",
                "type": "external"
            }
        ],
        "mass": 25519.0,
        "length": 235,
        "protein_name": "Motile sperm domain-containing protein 3",
        "gene_name": "MOSPD3",
        "organism": "Human",
        "refseq_name": "motile sperm domain-containing protein 3 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001035186",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035186",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MOSPD3",
        "gene_names_refseq": "CDS3; MOSPD3; NET30",
        "protein_names_uniprotkb": "Motile sperm domain-containing protein 3",
        "protein_names_refseq": "motile sperm domain-containing protein 3 isoform a; motile sperm domain-containing protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64598)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;15533722;18691976;29242379;33296653;33912179;35051231;9799793",
        "class_list": "",
        "function": "Deletion fo the Mospd3 locus is mutagenic and breeding to homozygosity results in a characteristic right ventricle defect and neonatal lethality in 50% of mice., [RefSeq, PubMed]; Human VAPome Analysis Reveals MOSPD1 and MOSPD3 as Membrane Contact Site Proteins Interacting with FFAT-Related FFNT Motifs. Erratum:[Cell Rep. 2023 Jul 25;42(7):112849. doi: 10.1016/j.celrep.2023.112849. PMID: 37440407], [RefSeq, PubMed]; This gene encodes a multi-pass membrane protein with a major sperm protein (MSP) domain. The deletion of a similar mouse gene is associated with defective cardiac development and neonatal lethality. Alternate transcriptional splice variants, encoding different isoforms, have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
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        "reported_snv": 8,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D2D1;A6NG17;C9JE89;D6W5W1;O75423;O75424",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "O75425-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96RE7-1",
        "uniprot_id": [
            {
                "id": "NACC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96RE7",
                "type": "external"
            }
        ],
        "mass": 57258.0,
        "length": 527,
        "protein_name": "Nucleus accumbens-associated protein 1",
        "gene_name": "NACC1",
        "organism": "Human",
        "refseq_name": "nucleus accumbens-associated protein 1",
        "refseq_ac": [
            {
                "id": "NP_443108",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443108",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NACC1; BTBD14B; NAC1",
        "gene_names_refseq": "BEND8; BTBD14B; BTBD30; NAC-1; NAC1; NACC1; NECFM",
        "protein_names_uniprotkb": "Nucleus accumbens-associated protein 1; BTB/POZ domain-containing protein 14B; NAC-1",
        "protein_names_refseq": "BEN domain containing 8; BTB/POZ domain-containing protein 14B; nucleus accumbens associated 1, BEN and BTB (POZ) domain containing; nucleus accumbens-associated protein 1; transcriptional repressor NAC1",
        "tax_id": 9606,
        "disease": "neurodevelopmental disorder with epilepsy, cataracts, feeding difficulties, and delayed brain myelination (MONDO:MONDO:0044306)",
        "pathway": " (hsa:112939)",
        "pathway_count": 1,
        "publication_count": 76,
        "publication_id_list": "11237011;15302935;17130457;17391728;17804717;18347169;18452278;18483383;18669648;19407373;20068231;23301498;23481700;24715725;25114211;25218447;25418920;25576301;25645385;25755297;25772364;26154972;26929215;26992070;27920218;28132692;28218747;28228285;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29557506;29632046;29632711;30315122;30410026;30429286;30779550;31092671;31154438;31530632;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32522876;32897882;32938616;32983136;33298915;33592498;33691108;33912179;33968037;33981976;34019948;34185709;34416910;34932366;35051231;35132862;35580925;35705054;36284347;37019189;37938771;38030057;38698576",
        "class_list": "",
        "function": "An overview of the co-transcription factor NACC1: Beyond its pro-tumor effects. Review article, [RefSeq, PubMed]; FUS-induced circRHOBTB3 facilitates cell proliferation via miR-600/NACC1 mediated autophagy response in pancreatic ductal adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Functions as a transcriptional repressor. Seems to function as a transcriptional corepressor in neuronal cells through recruitment of HDAC3 and HDAC4. Contributes to tumor progression, and tumor cell proliferation and survival. This may be mediated at least in part through repressing transcriptional activity of GADD45GIP1. Required for recruiting the proteasome from the nucleus to the cytoplasm and dendritic spines., [UniProtKB, PubMed, PubMed]; Hyperkinetic Movement Disorder Caused by the Recurrent c.892C>T NACC1 Variant., [RefSeq, PubMed]; Mechanistic insights of NAC1 nuclear export and its role in ovarian cancer resistance to docetaxel., [RefSeq, PubMed]; NAC-1 contributes to tumor growth and survival by at least inhibiting Gadd45GIP1 expression, which has a tumor suppressor effect in cancer cells., [RefSeq, PubMed]; NAC-1 expression is higher in ovarian carcinoma cells in effusions compared with their solid tumor counterparts., [RefSeq, PubMed]; NAC-1 is a tumor recurrence-associated gene with oncogenic potential; interactions between BTB/POZ domains of NAC-1 proteins are critical to form the discrete NAC-1 nuclear bodies and essential for tumor cell proliferation and survival., [RefSeq, PubMed]; NAC-1 may play an important role in cervical carcinomas., [RefSeq, PubMed]; NAC-1 regulates Taxol resistance in ovarian cancer, [RefSeq, PubMed]; This gene encodes a member of the BTB/POZ protein family. BTB/POZ proteins are involved in several cellular processes including proliferation, apoptosis and transcription regulation. The encoded protein is a transcriptional repressor that plays a role in stem cell self-renewal and pluripotency maintenance. The encoded protein also suppresses transcription of the candidate tumor suppressor Gadd45GIP1, and expression of this gene may play a role in the progression of multiple types of cancer. A pseudogene of this gene is located on the short arm of chromosome 9. [provided by RefSeq, Feb 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042826 histone deacetylase binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0045892 negative regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "Q96RE7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96BI1-1",
        "uniprot_id": [
            {
                "id": "S67A1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96BI1",
                "type": "external"
            }
        ],
        "mass": 44846.0,
        "length": 424,
        "protein_name": "Solute carrier family 67 member A1",
        "gene_name": "SLC67A1",
        "organism": "Human",
        "refseq_name": "solute carrier family 67 member A1 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001302430",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001302430",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC67A1; BWR1A; BWSCR1A; HET; IMPT1; ITM; ORCTL2; SLC22A18; SLC22A1L; TSSC5",
        "gene_names_refseq": "BWR1A; BWSCR1A; HET; IMPT1; ITM; ORCTL2; SLC22A18; SLC22A1L; SLC67A1; TSSC5; p45-BWR1A",
        "protein_names_uniprotkb": "Solute carrier family 67 member A1; Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein; Efflux transporter-like protein; Imprinted multi-membrane-spanning polyspecific transporter-related protein 1; ORCTL-2; Organic cation transporter-like protein 2; Solute carrier family 22 member 1-like; Solute carrier family 22 member 18; Tumor-suppressing STF cDNA 5 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein; p45-BWR1A; p45-Beckwith-Wiedemann region 1 A",
        "protein_names_refseq": "beckwith-Wiedemann syndrome chromosomal region 1 candidate gene A protein; efflux transporter-like protein; imprinted multi-membrane-spanning polyspecific transporter-like gene 1; imprinted multi-membrane-spanning polyspecific transporter-related protein 1; organic cation transporter-like protein 2; p45 Beckwith-Wiedemann region 1A; solute carrier family 22 member 18; solute carrier family 67 member A1 isoform a; solute carrier family 67 member A1; tumor-suppressing STF cDNA 5 protein; tumor-suppressing subchromosomal transferable fragment candidate gene 5 protein",
        "tax_id": 9606,
        "disease": "lung cancer (Disease Ontology:DOID:1324); breast cancer (Disease Ontology:DOID:1612); cancer (Disease Ontology:DOID:162); colon adenocarcinoma (Disease Ontology:DOID:234); embryonal rhabdomyosarcoma (Disease Ontology:DOID:3246); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); esophagus adenocarcinoma (Disease Ontology:DOID:4914)",
        "pathway": " (hsa:5002);  (R-HSA-549127);  (R-HSA-5619066)",
        "pathway_count": 3,
        "publication_count": 83,
        "publication_id_list": "10072434;10196521;10966924;11237011;12089149;12372408;12384147;14608356;14674884;15107849;15184985;15795384;16314844;16330770;16788146;16807400;17509534;18996451;20112406;23481700;24715725;25418920;25576301;25645385;26154972;26522469;26536134;26811146;27600516;27846572;27862975;28514659;28832583;28834231;28904123;29242379;29393594;29508533;29557506;29632046;29786170;29789417;30315122;30429286;30524438;30635741;31154438;31844290;31848261;32157095;32265295;32357974;32387766;32488085;32502341;32938616;32983136;33123756;33141586;33298915;33592498;33912179;33968037;34211107;34509645;35051231;35318648;35494241;35580925;36241641;36284347;38366023;7989337;8647271;9260930;9499412;9520460;9570947;9655880;9685390;9744804;9751628;9802569",
        "class_list": "",
        "function": "May act as a transporter of organic cations based on a proton efflux antiport mechanism. May play a role in the transport of chloroquine and quinidine-related compounds in kidney (PubMed:9744804). Plays a role in the regulation of lipid metabolism (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Mutational analysis of the two Sp1 sites suggested their requirement for the promoter activityof SLC22A18. GeneRIF: recent demonstration that the promoter of this gene is positively regulated by Sp1, [RefSeq, PubMed]; SLC22A18 gene is imprinted, with preferential expression from the maternal allele., [RefSeq, PubMed]; Suppression of SLC22A18 decreased the supply of intracellular free fatty acids from triglyceride-rich lipid droplets by impairing the lysosomal/autophagy degradation pathway and reduced the invasive activity of HepG2 cells by decreasing IGFBP-1 expression Publication Status: Online-Only, [RefSeq, PubMed]; The effect of genetic variants of SLC22A18 on proliferation, migration, and invasion of colon cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. This gene is imprinted, with preferential expression from the maternal allele. Mutations in this gene have been found in Wilms' tumor and lung cancer. This protein may act as a transporter of organic cations, and have a role in the transport of chloroquine and quinidine-related compounds in kidney. Several alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Oct 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 8,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O14906;O43562;O60485;O60680;Q7LDS5;Q7LGF7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0031625 ubiquitin protein ligase binding;GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0015695 organic cation transport;GO:0015837 amine transport;GO:0042908 xenobiotic transport;GO:1990961 xenobiotic detoxification by transmembrane export across the plasma membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 8.4,
        "record_id": "Q96BI1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NDS4-1",
        "uniprot_id": [
            {
                "id": "TBC3B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NDS4",
                "type": "external"
            }
        ],
        "mass": 62320.0,
        "length": 549,
        "protein_name": "TBC1 domain family member 3B",
        "gene_name": "TBC1D3B",
        "organism": "Human",
        "refseq_name": "TBC1 domain family member 3B",
        "refseq_ac": [
            {
                "id": "NP_001001417",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001417",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TBC1D3B; TBC1D3I",
        "gene_names_refseq": "PRC17; TBC1D3B; TBC1D3I",
        "protein_names_uniprotkb": "TBC1 domain family member 3B",
        "protein_names_refseq": "Rab GTPase-activating protein PRC17 duplicate; TBC1 domain family member 3B/I; TBC1 domain family member 3B; TBC1 domain family, member 3-like; TBC1 domain family, member 3I; prostate cancer gene 17 duplicate",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:414059)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;21030649",
        "class_list": "",
        "function": "Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity)., [UniProtKB]; This gene encodes a protein that is similar to TBC1 domain family, member 3. This protein contains a TBC (Tre-2, Bub2p, and Cdc16p) domain, which is found in proteins involved in RAB GTPase signaling and vesicle trafficking. There are multiple copies of this gene located within a cluster of chemokine genes on chromosome 17q. [provided by RefSeq, Apr 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K892",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity",
        "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "A6NDS4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00476-1",
        "uniprot_id": [
            {
                "id": "NPT4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00476",
                "type": "external"
            }
        ],
        "mass": 46106.0,
        "length": 420,
        "protein_name": "Sodium-dependent phosphate transport protein 4",
        "gene_name": "SLC17A3",
        "organism": "Human",
        "refseq_name": "sodium-dependent phosphate transport protein 4 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001091956",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001091956",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC17A3; NPT4",
        "gene_names_refseq": "GOUT4; NPT4; SLC17A3; UAQTL4",
        "protein_names_uniprotkb": "Sodium-dependent phosphate transport protein 4; NPT4; Na(+)/PI cotransporter 4; Sodium/phosphate cotransporter 4; Solute carrier family 17 member 3",
        "protein_names_refseq": "Na(+)/PI cotransporter 4; sodium-dependent phosphate transport protein 4 isoform a; sodium-dependent phosphate transport protein 4; sodium/phosphate cotransporter 4; solute carrier family 17 (organic anion transporter), member 3; solute carrier family 17 (sodium phosphate), member 3",
        "tax_id": 9606,
        "disease": "gout (Disease Ontology:DOID:13189); obsolete uric acid concentration, serum, quantitative trait locus 4 (MONDO:MONDO:0044277)",
        "pathway": " (hsa:10786);  (R-HSA-2672351)",
        "pathway_count": 2,
        "publication_count": 101,
        "publication_id_list": "10564087;10642508;10720933;10767424;10830164;10831588;11182090;11237011;11588175;11687798;11734858;11842292;11904445;11956057;12393854;12907679;1379744;14584882;14634667;15010458;15044642;15147738;15318163;15504734;15505377;15916532;15919655;16219661;16813530;16849430;16850186;17074750;17381423;17448995;17699613;17881003;18000046;18063579;18310267;18400985;18449189;18508966;18662336;18724360;18834626;19153159;19307298;19380724;19387438;19571809;19620632;19808995;19953639;20388639;20466723;20525693;20538786;20810651;21040849;21527911;21984732;22002868;22773952;22946059;2298749;23112050;2321095;23616951;2536303;26359375;26562072;27772792;28071645;28154142;28790369;29557506;30833945;31217245;32488085;34171305;34384670;34663856;35051231;7588753;7665160;7795595;8041726;8112288;8383669;8533761;8544406;8626462;8809036;9037075;9149941;9395096;9571199;9662395;9700209;9719863;9744806",
        "class_list": "",
        "function": "Brain age estimation at tract group level and its association with daily life measures, cardiac risk factors and genetic variants. Publication Status: Online-Only, [RefSeq, PubMed]; Mediates the renal excretion of uremic toxin 3-indoxyl sulfate., [UniProtKB, UniProtKB]; Mutation reduces the phosphate transport efficiency, possibly modulating the G6-Pase complex, [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study, meta-analysis, and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; SLC17A3 rs9379800 and Ischemic Stroke Susceptibility at the Northern Region of Malaysia., [RefSeq, PubMed]; Study used rs548987 of SLC17A3 as a candidate variant of ischemic stroke and performed association analysis in a Chinese population; although rs548987 failed to show significant association with total ischemic stroke and large vessel disease subtype, the C allele of rs548987 showed significant association with small vessel disease subtype of ischemic stroke (OR=0.68, p=0.004)., [RefSeq, PubMed]; The protein encoded by this gene is a voltage-driven transporter that excretes intracellular urate and organic anions from the blood into renal tubule cells. Two transcript variants encoding different isoforms have been found for this gene. The longer isoform is a plasma membrane protein with transporter activity while the shorter isoform localizes to the endoplasmic reticulum. [provided by RefSeq, Aug 2012]., [RefSeq]; Transports organic anions in a voltage-driven, multispecific, manner, on the apical side of renal proximal tubule (PubMed:20810651). In particular, participates in the secretion of urate from the cell into the lumen (PubMed:20810651). Urate is the end product of purine metabolism (PubMed:20810651). May have roles in the metabolism and secretion of estrone sulfate, estradiol-17-beta-glucuronide, ochratoxin A, as wells as drugs such as bumetanide (PubMed:20810651)., [UniProtKB, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
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        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7WNJ5;B7Z511;Q8WWC7;Q9H533",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042910 xenobiotic transmembrane transporter activity;GO:0022857 transmembrane transporter activity;GO:0019534 toxin transmembrane transporter activity;GO:0015562 efflux transmembrane transporter activity;GO:0008308 voltage-gated monoatomic anion channel activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0048471 perinuclear region of cytoplasm;GO:0005789 endoplasmic reticulum membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0034220 monoatomic ion transmembrane transport;GO:0046415 urate metabolic process;GO:0015711 organic anion transport;GO:0006814 sodium ion transport;GO:0006817 phosphate ion transport",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "O00476-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UGV2-1",
        "uniprot_id": [
            {
                "id": "NDRG3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UGV2",
                "type": "external"
            }
        ],
        "mass": 41409.0,
        "length": 375,
        "protein_name": "Protein NDRG3",
        "gene_name": "NDRG3",
        "organism": "Human",
        "refseq_name": "protein NDRG3 isoform b",
        "refseq_ac": [
            {
                "id": "NP_071922",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071922",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NDRG3",
        "gene_names_refseq": "NDRG3",
        "protein_names_uniprotkb": "Protein NDRG3; N-myc downstream-regulated gene 3 protein",
        "protein_names_refseq": "N-myc downstream-regulated gene 3 protein; protein NDRG3 isoform b; protein NDRG3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57446)",
        "pathway_count": 1,
        "publication_count": 79,
        "publication_id_list": "11237011;11352569;11936845;17081983;17322306;18077418;18669648;18767875;19413330;19651622;19690332;20068231;20166139;22299025;23186163;23301498;23481700;24275569;26154972;26811146;26992070;27452731;27846572;27862975;27920218;28228285;28467828;28832583;28834231;28871256;28904123;29242379;29314611;29351928;29508533;29557506;29632711;29786170;30315122;30524438;30833945;31154438;31844290;31935861;32157095;32161166;32350084;32387766;32488085;32897882;32938616;32983136;33141586;33298915;33562989;33583123;33592498;33912179;33936100;33968037;34171305;34185709;34357683;34509645;34932366;35051231;35154160;35251023;35318648;35494241;35580925;36010968;36241641;36284347;37172727;37350410;38838015;40596516;40914422",
        "class_list": "",
        "function": "Cloning and expression of the gene; highly expressed in brain and testis, [RefSeq, PubMed]; High expression of NDRG3 correlates with poor prognosis in gastric cancer patients., [RefSeq, PubMed]; Lactate promotes neuronal differentiation of SH-SY5Y cells by lactate-responsive gene sets through NDRG3-dependent and -independent manners., [RefSeq, PubMed]; NDRG3 regulates imatinib resistance by promoting beta-catenin accumulation in the nucleus in chronic myelogenous leukemia., [RefSeq, PubMed]; Structural and Biophysical Analyses of Human N-Myc Downstream-Regulated Gene 3 (NDRG3) Protein. Publication Status: Online-Only, [RefSeq, PubMed]; The LINC01410/miR-122-5p/NDRG3 axis is involved in the proliferation and migration of osteosarcoma cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 2,
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        "reported_phosphosites": 16,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A2S8;E1P5U7;E1P5U8;Q5TH32;Q96PL8;Q96SM2;Q9BXY7;Q9H3N7;Q9H411;Q9H8J6",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007283 spermatogenesis;GO:0030154 cell differentiation;GO:0030308 negative regulation of cell growth",
        "synthesized_glycan_count": 0,
        "hit_score": 8.3,
        "record_id": "Q9UGV2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NVZ3-1",
        "uniprot_id": [
            {
                "id": "NECP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NVZ3",
                "type": "external"
            }
        ],
        "mass": 28339.0,
        "length": 263,
        "protein_name": "Adaptin ear-binding coat-associated protein 2",
        "gene_name": "NECAP2",
        "organism": "Human",
        "refseq_name": "adaptin ear-binding coat-associated protein 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001138749",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138749",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NECAP2",
        "gene_names_refseq": "NECAP2",
        "protein_names_uniprotkb": "Adaptin ear-binding coat-associated protein 2; NECAP endocytosis-associated protein 2; NECAP-2",
        "protein_names_refseq": "adaptin ear-binding coat-associated protein 2 isoform 2; adaptin-ear-binding coat-associated protein 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55707);  (R-HSA-8856825);  (R-HSA-8856828)",
        "pathway_count": 3,
        "publication_count": 251,
        "publication_id_list": "10097102;10436022;10535736;10542231;10559856;10559861;10559924;10567358;10613896;10625686;10766823;10769163;10983987;11071885;11076969;11082044;11214971;11231140;11237011;11239472;11247302;11454741;11470803;11516654;11517213;11532990;11577110;11588219;11877457;11877461;11889126;11919637;11927540;11988742;12057195;12086608;12213833;12221107;12234931;12429842;12447393;12451172;12464600;12717448;12847086;12944396;12952949;12958364;1317852;14555962;14581451;14617351;14622578;14622579;14662753;14726597;15134832;15252009;15260957;15318165;15339664;1535555;15473838;15502812;15502813;15649145;15671180;15703209;15728179;15802264;15895077;15916959;16103228;16159959;16215232;16326391;16410077;16459302;16460808;16516836;16707488;16723738;16798879;16880396;16903783;17018281;17035995;17158794;17267500;17360967;17456551;17494869;17512409;17522231;17540576;17609109;17681954;17713526;17762867;17765681;17978091;18032517;18093523;18166656;18199683;18388313;1847920;18669648;18775314;18790740;18819912;18981233;19092055;19140243;19287005;19296720;19458185;19536138;19575674;19603039;1968060;19696796;19696798;19713939;19732400;19776351;19809571;19853559;20033059;20059951;20068231;20166139;20211604;20231386;20351096;20428113;20448150;20826345;20946875;21102408;2115402;21187331;21278753;21316588;21445324;21482805;21499258;21613550;21779028;21841790;21883765;21927000;21927001;21962517;21995445;22099461;22118466;22233676;22357968;22484487;22505844;2257624;22815487;22863004;22942912;23186163;23297414;23301498;23481700;23536704;23823722;23861397;23891661;24130457;24186068;24384571;24581490;24680432;24746795;24789820;24966051;25107275;25303366;25341920;25418920;25502872;25802875;25880248;26042225;26154972;26403691;26811146;26829388;26992070;27206861;27846572;27862975;27920218;28063628;28218747;28228285;28514659;28832583;2890644;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29786170;30315122;30410026;30626607;31154438;31217245;31844290;32157095;32161166;32265295;32387766;32502341;32938616;33298915;33968037;3417785;34185709;34357683;35051231;35580925;36010968;37938771;6146630;7569928;7822302;7877694;8524399;8552632;8553074;8837779;9092476;9100026;9169477;9303539;9427626;9428629;9635431;9723620;9736607;9812899",
        "class_list": "",
        "function": "Describes identification and characterization of rat NECAP1 and NECAP2 and their roles in endocytosis., [RefSeq, PubMed]; Involved in endocytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NECAP2 does not regulate the clathrin-mediated endocytosis of these cargos, the degradation of EGFR or the recycling of transferrin along the slow, Rab11-dependent recycling pathway. We show that protein knockdown of NECAP2 leads to enlarged early endosomes and causes the loss of the clathrin adapter AP-1 from the organelle., [RefSeq, PubMed]; This gene likely encodes a member of the adaptin-ear-binding coat-associated protein family. Studies of a similar protein in rat suggest a role in clathrin-mediated endocytosis. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DY19;E9PGQ8;Q5VSU4;Q5VSU5;Q9H7L1;Q9H8L1",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0030665 clathrin-coated vesicle membrane",
        "go_biological_process": "GO:0006897 endocytosis;GO:0015031 protein transport;GO:0016192 vesicle-mediated transport",
        "synthesized_glycan_count": 0,
        "hit_score": 25.4,
        "record_id": "Q9NVZ3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UXI9-1",
        "uniprot_id": [
            {
                "id": "NPNT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UXI9",
                "type": "external"
            }
        ],
        "mass": 61907.0,
        "length": 565,
        "protein_name": "Nephronectin",
        "gene_name": "NPNT",
        "organism": "Human",
        "refseq_name": "nephronectin isoform B precursor",
        "refseq_ac": [
            {
                "id": "NP_001028219",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001028219",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NPNT; EGFL6L; POEM; PRO334",
        "gene_names_refseq": "EGFL6L; NPNT; POEM",
        "protein_names_uniprotkb": "Nephronectin; Preosteoblast EGF-like repeat protein with MAM domain; Protein EGFL6-like",
        "protein_names_refseq": "nephronectin isoform B precursor; preosteoblast EGF-like repeat protein with MAM domain",
        "tax_id": 9606,
        "disease": "bilateral renal aplasia (Disease Ontology:DOID:0080200); membranous glomerulonephritis (Disease Ontology:DOID:10976); proteinuria (Disease Ontology:DOID:576)",
        "pathway": " (hsa:255743);  (R-HSA-9830364);  (R-HSA-9830674)",
        "pathway_count": 3,
        "publication_count": 21,
        "publication_id_list": "10.1038/emboj.2013.79;11237011;12975309;15754038;19844573;23584533;27846572;29242379;29508533;29557506;29741879;30459171;32350084;34411563;34433824;34716242;35246978;35304239;36292572;36870548;37074911",
        "class_list": "",
        "function": "A null founder variant in NPNT, encoding nephronectin, causes autosomal recessive renal agenesis., [RefSeq, PubMed]; Functional ligand of integrin alpha-8/beta-1 in kidney development. Regulates the expression of GDNF with integrin alpha-8/beta-1 which is essential for kidney development. May also play a role in the development and function of various tissues, regulating cell adhesion, spreading and survival through the binding of several integrins (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Glomerular Endothelial Cell-Derived microRNA-192 Regulates Nephronectin Expression in Idiopathic Membranous Glomerulonephritis., [RefSeq, PubMed]; Integrated analysis identified NPNT as a potential key regulator in tumor metastasis of hepatocellular carcinoma., [RefSeq, PubMed]; LncRNA ADAMTS9-AS1 inhibits the stemness of lung adenocarcinoma cells by regulating miR-5009-3p/NPNT axis., [RefSeq, PubMed]; MicroRNA miR-378 regulates nephronectin expression modulating osteoblast differentiation by targeting GalNT-7 Publication Status: Online-Only, [RefSeq, PubMed]; Missense Variants in <i>GFRA1</i> and <i>NPNT</i> Are Associated with Congenital Anomalies of the Kidney and Urinary Tract. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
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        "reported_fully_resolved_glycans": 2,
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        "reported_snv": 18,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 29,
        "disease_count": 3,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NFT9;A8K1W4;B4DIT4;B4DYK3;B4E2H7;B4E3H2;D6RCA1;E9PCK8;E9PCQ1;E9PE64;E9PF04",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0016020 membrane;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome;GO:0030485 smooth muscle contractile fiber",
        "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0045987 positive regulation of smooth muscle contraction;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0007160 cell-matrix adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q6UXI9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000001000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y6X3-1",
        "uniprot_id": [
            {
                "id": "SCC4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y6X3",
                "type": "external"
            }
        ],
        "mass": 69082.0,
        "length": 613,
        "protein_name": "MAU2 chromatid cohesion factor homolog",
        "gene_name": "MAU2",
        "organism": "Human",
        "refseq_name": "MAU2 chromatid cohesion factor homolog",
        "refseq_ac": [
            {
                "id": "NP_056144",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056144",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAU2; KIAA0892; SCC4",
        "gene_names_refseq": "CDLS7; KIAA0892; MAU2L; MAU2; SCC4; mau-2",
        "protein_names_uniprotkb": "MAU2 chromatid cohesion factor homolog; Cohesin loading complex subunit SCC4 homolog; MAU-2",
        "protein_names_refseq": "MAU2 chromatid cohesion factor homolog; cohesin loading complex subunit SCC4 homolog; protein MAU-2; sister chromatid cohesion 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23383);  (R-HSA-2470946)",
        "pathway_count": 2,
        "publication_count": 78,
        "publication_id_list": "11237011;16682347;16802858;17112726;17113138;19696148;20058876;20068231;21934712;22424782;22628566;23301498;24714562;24715725;25576301;26154972;26992070;27600516;27846572;27862975;28167679;28218747;28228285;28832583;28834231;28904123;29242379;29351928;29393594;29437277;29493099;29508533;29557506;29611806;29632711;29786170;30315122;30410026;30429286;31217245;31844290;32157095;32357974;32387766;32433956;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33392160;33592498;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34357683;34405274;34509645;34932366;35051231;35318648;35580925;36010968;36241641;36284347;37938771;39742660;40596516",
        "class_list": "",
        "function": "Here, the authors show that, in human cells, cohesin loading onto chromosomes during early S phase requires the replicative helicase MCM2-7 and the kinase DDK. Cohesin and its loader SCC2/4 (NIPBL/MAU2 in humans) associate with DDK and phosphorylated MCM2-7. Publication Status: Online-Only, [RefSeq, PubMed]; Human MAU-2 family member has weak similarity to yeast Scc4 and is associated with Scc2, bound to chromatin from telophase until prophase, and required for association of cohesin with chromatin during interphase, [RefSeq, PubMed]; MAU2 and NIPBL Variants Impair the Heterodimerization of the Cohesin Loader Subunits and Cause Cornelia de Lange Syndrome., [RefSeq, PubMed]; Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with NIPBL/SCC2 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28167679). Plays a role in sister chromatid cohesion and normal progression through prometaphase (PubMed:16682347, PubMed:16802858)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Specific novel mutations at the N-terminus of the MAU2-interacting domain of NIBPL result in markedly reduced MAU2 binding. Erratum:[Eur J Hum Genet. 2012 Mar;20(3):366], [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q66PT1;Q6P3S7;Q6ZTT2;Q9UFX8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0061775 cohesin loader activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0016604 nuclear body;GO:0000785 chromatin;GO:0032116 SMC loading complex",
        "go_biological_process": "GO:0007059 chromosome segregation;GO:0051301 cell division;GO:0007064 mitotic sister chromatid cohesion;GO:0034088 maintenance of mitotic sister chromatid cohesion;GO:0140588 chromatin looping",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "Q9Y6X3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NC96-1",
        "uniprot_id": [
            {
                "id": "NECP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NC96",
                "type": "external"
            }
        ],
        "mass": 29737.0,
        "length": 275,
        "protein_name": "Adaptin ear-binding coat-associated protein 1",
        "gene_name": "NECAP1",
        "organism": "Human",
        "refseq_name": "adaptin ear-binding coat-associated protein 1",
        "refseq_ac": [
            {
                "id": "NP_056324",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056324",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NECAP1",
        "gene_names_refseq": "DEE21; EIEE21; NECAP1",
        "protein_names_uniprotkb": "Adaptin ear-binding coat-associated protein 1; NECAP endocytosis-associated protein 1; NECAP-1",
        "protein_names_refseq": "adaptin ear-binding coat-associated protein 1",
        "tax_id": 9606,
        "disease": "developmental and epileptic encephalopathy 21 (Disease Ontology:DOID:0080443)",
        "pathway": " (hsa:25977);  (R-HSA-432722);  (R-HSA-8856825);  (R-HSA-8856828)",
        "pathway_count": 4,
        "publication_count": 246,
        "publication_id_list": "10.1101/2023.09.13.557529;10097102;10394364;10436022;10535736;10542231;10559856;10559861;10559924;10567358;10613896;10625686;10766823;10769163;10983987;11071885;11076969;11082044;11231140;11237011;11239472;11247302;11454741;11470803;11516654;11517213;11532990;11577110;11588219;11590181;11604418;11694590;11877457;11877461;11889126;11919637;11927540;11988742;11994746;12057195;12086608;12213833;12221107;12234931;12429842;12447393;12451172;12464600;12717448;12847086;12944396;12952949;12958364;1317852;14555962;14581451;14617351;14622578;14622579;14662753;14726597;15102850;15134832;15252009;15260957;15318165;15339664;1535555;15473838;15502812;15502813;15649145;15671180;15703209;15728179;15802264;15895077;15916959;16103228;16155256;16159959;16215232;16326391;16410077;16459302;16460808;16516836;16707488;16723738;16798879;16880396;16903783;17018281;17035995;17116749;17158794;17267500;17360967;17456551;17494869;17512409;17522231;17540576;17609109;17681954;17713526;17762867;17765681;17978091;18032517;18093523;18166656;18199683;18388313;1847920;18691976;18775314;18790740;18819912;18981233;19092055;19140243;19287005;19296720;19458185;19536138;19575674;19603039;1968060;19696796;19696798;19713939;19732400;19776351;19809571;19853559;20033059;20059951;20068231;20112406;20211604;20231386;20351096;20428113;20448150;20826345;20946875;21102408;2115402;21187331;21278753;21316588;21445324;21482805;21499258;21613550;21779028;21841790;21883765;21927000;21927001;21962517;21995445;22099461;22118466;22233676;22357968;22484487;22505844;2257624;22815487;22863004;22942912;23186163;23297414;23536704;23823722;23861397;23891661;24129315;24130457;24186068;24384571;24399846;24581490;24680432;24746795;24789820;24966051;25107275;25303366;25341920;25418920;25469497;26042225;26154972;26403691;26811146;26829388;26929215;26992070;27846572;27920218;28218747;28860189;2890644;29393594;29437277;29485866;29557506;29632046;30315122;30410026;31373491;31430451;31844290;32157095;32161166;32387766;32938616;33537174;3417785;34185709;35580925;36010968;38665916;6146630;7569928;7822302;7877694;8374173;8524399;8552632;8553074;8670264;8837779;9092476;9100026;9169477;9303539;9427626;9428629;9635431;9723620;9736607;9812899",
        "class_list": "",
        "function": "Involved in endocytosis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; NECAP recruits drivers of late stages of clathrin-coated pit (CCP) formation, including SNX9, via a site distinct from where NECAP binds AP2. Erratum:[Dev Cell. 2020 Mar 9;52(5):673. doi: 10.1016/j.devcel.2020.02.010. PMID: 32155440], [RefSeq, PubMed]; NECAP1 mutation links trafficking pathway in early infantile epileptic encephalopathy., [RefSeq, PubMed]; This gene encodes a protein containing two characteristic WXXF motifs. The encoded protein localizes to clathrin-coated vesicles, where it binds components of the adapter protein complexes and aids in endocytosis. Loss of function of this gene results in early infantile epileptic encephalopathy-21. There is a pseudogene for this gene on chromosome 7. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jun 2014]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2NL73;Q5XG95;Q6NWY6;Q8N153;Q8NCB0;Q9BU52;Q9Y407",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005905 clathrin-coated pit;GO:0098793 presynapse",
        "go_biological_process": "GO:0015031 protein transport;GO:0016192 vesicle-mediated transport;GO:0140238 presynaptic endocytosis;GO:0006897 endocytosis",
        "synthesized_glycan_count": 0,
        "hit_score": 25.2,
        "record_id": "Q8NC96-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P59047-1",
        "uniprot_id": [
            {
                "id": "NALP5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P59047",
                "type": "external"
            }
        ],
        "mass": 134342.0,
        "length": 1200,
        "protein_name": "NACHT, LRR and PYD domains-containing protein 5",
        "gene_name": "NLRP5",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "NLRP5; MATER; NALP5",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 5; Mater protein homolog; Maternal Antigen that Embryos Require",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "oocyte/zygote/embryo maturation arrest 19 (MONDO:MONDO:0957231)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 29,
        "publication_id_list": "11237011;11925379;12563287;19192343;19542546;24374158;25542835;26323243;26992070;27397612;28254787;28501589;29557506;29789417;30218098;30877238;31154438;31530632;31829238;32222962;32502341;33020905;33073652;33141586;35051231;35946397;37148315;37922900;39379527",
        "class_list": "",
        "function": "Component of the subcortical maternal complex (SCMC), a multiprotein complex that plays a key role in early embryonic development. The SCMC complex is a structural constituent of cytoplasmic lattices, which consist in fibrous structures found in the cytoplasm of oocytes and preimplantation embryos. They are required to store maternal proteins critical for embryonic development, such as proteins that control epigenetic reprogramming of the preimplantation embryo, and prevent their degradation or activation. Required for the localization of cortical granules to the cortex of oocytes, via association with the cortical actin scaffold. Required for cortical actin clearance prior to oocyte exocytosis and prevention of polyspermy. Involved in regulating post-fertilization Ca(2+) release and endoplasmic reticulum storage (ER) storage via regulation of cellular localization. May be involved in the localization of mitochondria to the cytoplasm and perinuclear region in oocytes and early stage embryos, independent of its role in CPL formation., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "reported_mutagensis": 3,
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        "reported_snv": 62,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MTY4;Q86W29",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0015631 tubulin binding;GO:0140094 structural constituent of cytoplasmic lattice",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0051293 establishment of spindle localization;GO:0007015 actin filament organization;GO:0032880 regulation of protein localization;GO:0050727 regulation of inflammatory response;GO:0040019 positive regulation of embryonic development",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "P59047-1",
        "record_type": "protein",
        "filter_code": "0000000.1100110.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P25929-1",
        "uniprot_id": [
            {
                "id": "NPY1R_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P25929",
                "type": "external"
            }
        ],
        "mass": 44392.0,
        "length": 384,
        "protein_name": "Neuropeptide Y receptor type 1",
        "gene_name": "NPY1R",
        "organism": "Human",
        "refseq_name": "neuropeptide Y receptor type 1",
        "refseq_ac": [
            {
                "id": "NP_000900",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000900",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NPY1R; NPYR; NPYY1",
        "gene_names_refseq": "NPY1-R; NPY1R; NPYR",
        "protein_names_uniprotkb": "Neuropeptide Y receptor type 1; NPY1-R",
        "protein_names_refseq": "neuropeptide Y receptor type 1",
        "tax_id": 9606,
        "disease": "nicotine dependence (Disease Ontology:DOID:0050742); peripheral artery disease (Disease Ontology:DOID:0050830); stroke (Disease Ontology:DOID:0051061); absence epilepsy (Disease Ontology:DOID:0070309); hypertension (Disease Ontology:DOID:10763); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); anxiety disorder (Disease Ontology:DOID:2030); opiate dependence (Disease Ontology:DOID:2559); temporal lobe epilepsy (Disease Ontology:DOID:3328); amphetamine abuse (Disease Ontology:DOID:670); cocaine abuse (Disease Ontology:DOID:809); obesity (Disease Ontology:DOID:9970); heroin dependence (Disease Ontology:DOID:9976)",
        "pathway": " (hsa:4886);  (R-HSA-375276);  (R-HSA-418594)",
        "pathway_count": 3,
        "publication_count": 128,
        "publication_id_list": "10079109;10100623;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10604470;10854085;10899166;11007482;11237011;11322507;11385580;11457843;11562423;11683476;11773063;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1321422;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15539556;1567413;15947423;15951850;1655761;16634148;16923326;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18577758;19413330;23446738;23481700;23690594;24906252;2534964;2649896;26992070;2748346;27496565;27862975;2834384;29242379;29557506;30779550;31848261;3202875;32157095;32161166;32387766;3366244;33968037;34087483;35093384;35121782;35165283;3525564;35401881;35507650;35580925;3856870;38882210;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8015379;8035319;8062389;8063797;8095935;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8406495;8440682;8463333;8503909;8615752;8666380;8702752;873923;8823230;9171878;9521323;9530155;9593744;9607765;9685625;9722565;9792798;9832121;9851594",
        "class_list": "",
        "function": "Expression of hypoxia inducible factor-dependent neuropeptide Y receptors Y1 and Y5 sensitizes hypoxic cells to NPY stimulation., [RefSeq, PubMed]; Integrative Analysis of Exosomal miR-452 and miR-4713 Downregulating NPY1R for the Prevention of Childhood Obesity. Publication Status: Online-Only, [RefSeq, PubMed]; NPY1R exerts inhibitory action on estradiol-stimulated growth and predicts endocrine sensitivity and better survival in ER-positive breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor for neuropeptide Y (NPY) and peptide YY (PYY) (PubMed:1317848, PubMed:1321422, PubMed:35165283, PubMed:35507650, PubMed:38882210). Can also bind with high affinity [Leu-31, Pro-34]NPY, an analog of NPY modified at residues 31 and 34 of the mature form, while having virtually no affinity for pancreatic polypeptide (PP/PPY) at physiological concentrations (PubMed:1321422, PubMed:38882210). NPY or PYY binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production (PubMed:1317848, PubMed:1321422, PubMed:35507650, PubMed:38882210). Receptor activation by ligands also leads to an increase of intracellular Ca(2+) levels (PubMed:1317848, PubMed:1321422, PubMed:35165283). As a receptor for NPY, it is involved in the regulation of eating behaviour and NPY-induced stimulation of food intake (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, UniProtKB, PubMed]; Structural basis of neuropeptide Y signaling through Y1 receptor. Erratum:[Nat Commun. 2022 Feb 25;13(1):1126. doi: 10.1038/s41467-022-28837-0. PMID: 35217654] Publication Status: Online-Only, [RefSeq, PubMed]; This gene belongs to the G-protein-coupled receptor superfamily. The encoded transmembrane protein mediates the function of neuropeptide Y (NPY), a neurotransmitter, and peptide YY (PYY), a gastrointestinal hormone. The encoded receptor undergoes fast agonist-induced internalization through clathrin-coated pits and is subsequently recycled back to the cell membrane. Activation of Y1 receptors may result in mobilization of intracellular calcium and inhibition of adenylate cyclase activity. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 20,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 14,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6H5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008188 neuropeptide receptor activity;GO:0004983 neuropeptide Y receptor activity;GO:0001601 peptide YY receptor activity;GO:0001602 pancreatic polypeptide receptor activity;GO:0004930 G protein-coupled receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043005 neuron projection",
        "go_biological_process": "GO:1904000 positive regulation of eating behavior;GO:0007193 adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007187 G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger;GO:0003151 outflow tract morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 12.9,
        "record_id": "P25929-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43447-1",
        "uniprot_id": [
            {
                "id": "PPIH_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43447",
                "type": "external"
            }
        ],
        "mass": 19208.0,
        "length": 177,
        "protein_name": "Peptidyl-prolyl cis-trans isomerase H",
        "gene_name": "PPIH",
        "organism": "Human",
        "refseq_name": "peptidyl-prolyl cis-trans isomerase H isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001317439",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001317439",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PPIH; CYP20; CYPH",
        "gene_names_refseq": "CYP-20; CYPH; PPIH; SnuCyp-20; USA-CYP",
        "protein_names_uniprotkb": "Peptidyl-prolyl cis-trans isomerase H; 5.2.1.8; CypH; PPIase H; Rotamase H; Small nuclear ribonucleoprotein particle-specific cyclophilin H; U-snRNP-associated cyclophilin SnuCyp-20; USA-CYP",
        "protein_names_refseq": "PPIase h; U-snRNP-associated cyclophilin SnuCyp-20; U-snRNP-associated cyclophilin SunCyp-20; USA-CyP SnuCyp-20; cyclophilin H; peptidyl-prolyl cis-trans isomerase H isoform 2; peptidyl-prolyl cis-trans isomerase H; rotamase H; small nuclear ribonucleoprotein particle-specific cyclophilin H",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10465);  (R-HSA-72163);  (R-HSA-9692916)",
        "pathway_count": 3,
        "publication_count": 148,
        "publication_id_list": "10713041;10882114;11014198;11101529;11233976;11237011;11823439;11991638;12176931;12411573;12414731;12477934;12875835;14625303;14713954;15208624;16314458;16723661;16809785;17035307;17095540;17270291;17332742;17412287;17596301;17606899;17761676;18322460;18593880;19103666;19165350;19380580;19398035;19536130;20423332;20676357;20980672;21536652;2176635;22046132;22110043;22121020;22253733;22312431;22365833;22645359;22959432;22961380;23222130;23236153;23345524;23483519;24196718;24304693;24448447;24509444;24622840;24737827;24854014;24914973;25135833;25418920;25555158;2558966;25764917;25907116;26320399;26378163;26385511;26420826;26969736;26992070;27164085;27203180;27377154;27459055;27683217;28062851;28076346;28148787;28502770;28510447;28781166;28904123;29294448;29301961;29360106;29361316;29493099;29557506;2963332;30185776;30315277;30705154;30728453;30765414;30975767;31034780;31217245;31231549;31409651;31844290;32157095;32179686;32329775;32350084;32357974;32387766;32494006;32728199;32897882;33060197;33243851;33446560;33537174;33592498;33633747;33936100;33968037;34019948;34171305;34301950;34357683;34561969;34822310;34932366;35051231;35251023;35385551;35561310;35580925;36241641;36284347;3757028;37874737;8566756;8608946;9016565;9242493;9404889;9512519;9524131;9539711;9570313;9671485;9701291;9731529;9989503",
        "class_list": "",
        "function": "Free and complexed cyclophilin H have virtually identical conformations suggesting that the U4/U6-60K binding site is pre-shaped and the peptidyl-prolyl-cis/trans isomerase activity is unaffected by complex formation, [RefSeq, PubMed]; PPIH gene regulation system and its prognostic significance in hepatocellular carcinoma: a comprehensive analysis., [RefSeq, PubMed]; PPIase that catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and may therefore assist protein folding. Participates in pre-mRNA splicing. May play a role in the assembly of the U4/U5/U6 tri-snRNP complex, one of the building blocks of the spliceosome. May act as a chaperone., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the peptidyl-prolyl cis-trans isomerase (PPIase) family. PPIases catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides and accelerate the folding of proteins. This protein is a specific component of the complex that includes pre-mRNA processing factors PRPF3, PRPF4, and PRPF18, as well as U4/U5/U6 tri-snRNP. This protein has been shown to possess PPIase activity and may act as a protein chaperone that mediates the interactions between different proteins inside the spliceosome. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NNE7",
        "ec_number_list": [
            {
                "id": "5.2.1.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.2.1.8",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.1.13.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-",
                "type": "external"
            },
            {
                "id": "2.7.7.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48",
                "type": "external"
            },
            {
                "id": "2.7.7.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0043021 ribonucleoprotein complex binding;GO:0016018 cyclosporin A binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0005681 spliceosomal complex",
        "go_biological_process": "GO:0006457 protein folding;GO:0000398 mRNA splicing, via spliceosome;GO:0045070 positive regulation of viral genome replication;GO:0065003 protein-containing complex assembly;GO:0006397 mRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 15.1,
        "record_id": "O43447-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P51168-1",
        "uniprot_id": [
            {
                "id": "SCNNB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P51168",
                "type": "external"
            }
        ],
        "mass": 72659.0,
        "length": 640,
        "protein_name": "Epithelial sodium channel subunit beta",
        "gene_name": "SCNN1B",
        "organism": "Human",
        "refseq_name": "epithelial sodium channel subunit beta isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000327",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000327",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SCNN1B",
        "gene_names_refseq": "BESC1; ENaCbeta; ENaCb; LIDLS1; PHA1B2; SCNEB; SCNN1B; beta-ENaC; beta-NaCH",
        "protein_names_uniprotkb": "Epithelial sodium channel subunit beta; Amiloride-sensitive sodium channel subunit beta; Beta-ENaC; Beta-NaCH; ENaC subunit beta; ENaCB; Epithelial Na(+) channel subunit beta; Nonvoltage-gated sodium channel 1 subunit beta; SCNEB",
        "protein_names_refseq": "ENaC subunit beta; amiloride-sensitive sodium channel subunit beta 1; epithelial Na(+) channel subunit beta; epithelial sodium channel beta-2 subunit; epithelial sodium channel beta-3 subunit; epithelial sodium channel subunit beta isoform 1; epithelial sodium channel subunit beta; mutant sodium channel epithelial 1 beta subunit; nasal epithelial sodium channel beta subunit; nonvoltage-gated sodium channel 1 subunit beta; sodium channel epithelial 1 beta subunit; sodium channel, non-voltage-gated 1, beta subunit",
        "tax_id": 9606,
        "disease": "Liddle syndrome (Disease Ontology:DOID:0050477); autosomal recessive pseudohypoaldosteronism type 1 (Disease Ontology:DOID:0060854); bronchiectasis 1 (Disease Ontology:DOID:0080526); nephrotic syndrome (Disease Ontology:DOID:1184); newborn respiratory distress syndrome (Disease Ontology:DOID:12716); neurodegenerative disease (Disease Ontology:DOID:1289); hypokalemic periodic paralysis (Disease Ontology:DOID:14452); cystic fibrosis (Disease Ontology:DOID:1485); ischemia (Disease Ontology:DOID:326); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); pseudohypoaldosteronism (Disease Ontology:DOID:4479); bronchiectasis (Disease Ontology:DOID:9563); pseudohypoaldosteronism, type IB2, autosomal recessive (MONDO:MONDO:0859317)",
        "pathway": " (hsa:6338);  (R-HSA-2672351);  (R-HSA-9730628)",
        "pathway_count": 3,
        "publication_count": 142,
        "publication_id_list": "10404817;10564087;10642508;10720933;10767424;10830164;10831588;11182090;11237011;11244092;11588175;11687798;11734858;11805112;11842292;11904445;11956057;12107247;12167593;12393854;12714866;12907679;1379744;14584882;14634667;15010458;15044642;15147738;15318163;15483078;15504734;15505377;15853823;15916532;15919655;16207733;16219661;16423824;16813530;16849430;16850186;16959974;17381423;17448995;17502380;17699613;17881003;18000046;18063579;18174164;18310267;18400985;18449189;18507830;18508966;18634878;18662336;18724360;19017867;19153159;19307298;19380724;19387438;1939532;19620632;19808995;19953639;20064610;20388639;20466723;20525693;20538786;21040849;21527911;21984732;22002868;22207244;22493497;22773952;22946059;2298749;23112050;2321095;23481700;23616951;24043776;24124190;24190977;2536303;25892735;26359375;26375851;26562072;26772908;28071645;28154142;28588583;28790369;29557506;30251954;32729833;33298915;34185709;35051231;35580925;36215666;36284347;36899055;37074911;37477776;39415304;7490094;7499195;7550319;7588753;7665160;7762608;7795595;7954808;8041726;8112288;8383669;8524790;8533761;8544406;8589714;8601645;8626462;8809036;9037075;9169421;9395096;9571199;9626162;9662395;9674649;9700209;9719863;9744806;9792722;9794716;9813171",
        "class_list": "",
        "function": "Genetic variation in salt taste receptors impact salt intake and blood pressure. Publication Status: Online-Only, [RefSeq, PubMed]; Hypermethylation of the sodium channel beta subunit gene promoter is associated with colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Nonvoltage-gated, amiloride-sensitive, sodium channels control fluid and electrolyte transport across epithelia in many organs. These channels are heteromeric complexes consisting of 3 subunits: alpha, beta, and gamma. This gene encodes the beta subunit, and mutations in this gene have been associated with pseudohypoaldosteronism type 1 (PHA1), and Liddle syndrome. [provided by RefSeq, Apr 2009]., [RefSeq]; SCNN1B regulates the proliferation, migration, and collagen deposition of human lung fibroblasts., [RefSeq, PubMed]; This is one of the three pore-forming subunits of the heterotrimeric epithelial sodium channel (ENaC), a critical regulator of sodium balance and fluid homeostasis (PubMed:30251954, PubMed:32729833, PubMed:7762608, PubMed:9792722). ENaC operates in epithelial tissues, where it mediates the electrodiffusion of sodium ions from extracellular fluid through the apical membrane of cells, with water following osmotically (PubMed:24124190). It plays a key role in maintaining sodium homeostasis through electrogenic sodium reabsorption in the kidneys (PubMed:12107247). Additionally, ENaC is essential for airway surface liquid homeostasis, which is crucial for proper mucus clearance (PubMed:24124190)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 34,
        "reported_interactions": 0,
        "missing_score": 9562,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 13,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C5HTZ2;O60891;Q96KG2;Q9UJ32;Q9UMU5",
        "ec_number_list": [
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0050699 WW domain binding;GO:0015280 ligand-gated sodium channel activity;GO:0005272 sodium channel activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0009897 external side of plasma membrane;GO:0016324 apical plasma membrane;GO:0030659 cytoplasmic vesicle membrane",
        "go_biological_process": "GO:0008217 regulation of blood pressure;GO:1904117 cellular response to vasopressin;GO:0006883 intracellular sodium ion homeostasis;GO:0035725 sodium ion transmembrane transport;GO:1904045 cellular response to aldosterone",
        "synthesized_glycan_count": 0,
        "hit_score": 15.6,
        "record_id": "P51168-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14604-1",
        "uniprot_id": [
            {
                "id": "TYB4Y_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14604",
                "type": "external"
            }
        ],
        "mass": 5013.0,
        "length": 44,
        "protein_name": "Thymosin beta-4, Y-chromosomal",
        "gene_name": "TMSB4Y",
        "organism": "Human",
        "refseq_name": "thymosin beta-4, Y-chromosomal",
        "refseq_ac": [
            {
                "id": "NP_004193",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004193",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TMSB4Y; TB4Y",
        "gene_names_refseq": "TB4Y; TMSB4Y",
        "protein_names_uniprotkb": "Thymosin beta-4, Y-chromosomal",
        "protein_names_refseq": "thymosin beta-4, Y-chromosomal; thymosin, beta 4, Y chromosome",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9087)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "15557202;19369144;26154972;26702755;27846572;29393594;29493099;29557506;30379171;31611695;31844290;32387766;33141586;33356743;33592498;33717175;33936100;34171305;9381176",
        "class_list": "",
        "function": "MiR-183/TMSB4Y, a new potential signaling axis, involving in the progression of laryngeal cancer via modulating cell adhesion., [RefSeq, PubMed]; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity)., [UniProtKB]; Suggest Y chromosome gene TMSB4Y may function as a tumor suppressor gene in male breast cancer., [RefSeq, PubMed]; T beta 4 is a key activator of NK cell cytotoxicity., [RefSeq, PubMed]; TMSB4Y has been found to encode a novel HLA-A*3303-restricted minor histocompatibility H-Y antigen, revealed during cytotoxicity assays of T cell lines from a female-to-male hemopoietic stem cell transplantation patient., [RefSeq, PubMed]; This gene lies within the male specific region of chromosome Y. Its homolog on chromosome X escapes X inactivation and encodes an actin sequestering protein. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0VDA2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003785 actin monomer binding;GO:0140311 protein sequestering activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0008064 regulation of actin polymerization or depolymerization;GO:0007015 actin filament organization;GO:0030334 regulation of cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "O14604-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "E9PIF3-1",
        "uniprot_id": [
            {
                "id": "NPIA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/E9PIF3",
                "type": "external"
            }
        ],
        "mass": 42223.0,
        "length": 369,
        "protein_name": "Nuclear pore complex-interacting protein family member A2",
        "gene_name": "NPIPA2; NPIPA3",
        "organism": "Human",
        "refseq_name": "nuclear pore complex-interacting protein family member A2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001382414",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001382414",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NPIPA2; NPIPA3; NPIPA2",
        "gene_names_refseq": "NPIPA2; NPIP",
        "protein_names_uniprotkb": "Nuclear pore complex-interacting protein family member A2",
        "protein_names_refseq": "nuclear pore complex-interacting protein family member A2 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:642799)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
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        "predicted_o_glycosites": 1,
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
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        "record_id": "E9PIF3-1",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75764-1",
        "uniprot_id": [
            {
                "id": "TCEA3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75764",
                "type": "external"
            }
        ],
        "mass": 38972.0,
        "length": 348,
        "protein_name": "Transcription elongation factor A protein 3",
        "gene_name": "TCEA3",
        "organism": "Human",
        "refseq_name": "transcription elongation factor A protein 3",
        "refseq_ac": [
            {
                "id": "NP_003187",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003187",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TCEA3; TFIISH",
        "gene_names_refseq": "TCEA3; TFIIS.H; TFIIS",
        "protein_names_uniprotkb": "Transcription elongation factor A protein 3; Transcription elongation factor S-II protein 3; Transcription elongation factor TFIIS.h",
        "protein_names_refseq": "rhabdomyosarcoma antigen MU-RMS-40.22; transcription elongation factor A (SII), 3; transcription elongation factor A protein 3; transcription elongation factor S-II protein 3; transcription elongation factor TFIIS.h",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6920)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;18767875;19913121;20166139;20178742;20628086;24275569;25576301;26498664;27005522;29437277;29493099;29557506;31844290;31988307;32938616;33968037;35051231;37217939;39198937;9790746",
        "class_list": "",
        "function": "Findings reveal a novel mechanism by which p53 utilizes TFIIS.h to selectively promote the transcriptional elongation of the bax gene, upsurging cell death in response to severe DNA damage. Publication Status: Online-Only, [RefSeq, PubMed]; Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus., [UniProtKB, UniProtKB, UniProtKB]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Oncogenic tRNA-derived fragment tRF-Leu-CAG promotes tumorigenesis of lung cancer via targeting TCEA3 and increasing autophagy., [RefSeq, PubMed]; Study demonstrates a strong synergy between hPAF1C and elongation factor SII/TFIIS and an underlying mechanism involving direct hPAF1C-SII interactions and cooperative binding to RNA polymerase II., [RefSeq, PubMed]; TCEA3 attenuates the proliferation and induces apoptosis of gastric cancer cells Publication Status: Online-Only, [RefSeq, PubMed]; The transcription elongation factor TCEA3 induces apoptosis in rhabdomyosarcoma. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "secondary_ac_list": "A8K2K7;Q5DR83",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0003711 transcription elongation factor activity",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006368 transcription elongation by RNA polymerase II",
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        "hit_score": 2.4,
        "record_id": "O75764-1",
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    },
    {
        "uniprot_canonical_ac": "P43354-1",
        "uniprot_id": [
            {
                "id": "NR4A2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P43354",
                "type": "external"
            }
        ],
        "mass": 66591.0,
        "length": 598,
        "protein_name": "Nuclear receptor subfamily 4 group A member 2",
        "gene_name": "NR4A2",
        "organism": "Human",
        "refseq_name": "nuclear receptor subfamily 4 group A member 2 isoform a",
        "refseq_ac": [
            {
                "id": "NP_006177",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006177",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NR4A2; NOT; NURR1; TINUR",
        "gene_names_refseq": "HZF-3; IDLDP; NOT; NR4A2; NURR1; RNR1; TINUR",
        "protein_names_uniprotkb": "Nuclear receptor subfamily 4 group A member 2; Immediate-early response protein NOT; Orphan nuclear receptor NURR1; Transcriptionally-inducible nuclear receptor",
        "protein_names_refseq": "NGFI-B/nur77 beta-type transcription factor homolog; T-cell nuclear receptor NOT; immediate-early response protein NOT; intermediate-early receptor protein; nuclear receptor subfamily 4 group A member 2 isoform a; nur related protein-1, human homolog of; orphan nuclear receptor NR4A2; orphan nuclear receptor NURR1; transcriptionally inducible nuclear receptor related 1; transcriptionally-inducible nuclear receptor",
        "tax_id": 9606,
        "disease": "Parkinsonism (Disease Ontology:DOID:0080855); Parkinson's disease (Disease Ontology:DOID:14330); epilepsy (Disease Ontology:DOID:1826); schizophrenia (Disease Ontology:DOID:5419); intellectual developmental disorder with language impairment and early-onset DOPA-responsive dystonia-parkinsonism (MONDO:MONDO:0859257)",
        "pathway": " (hsa:4929);  (R-HSA-383280);  (R-HSA-4090294)",
        "pathway_count": 3,
        "publication_count": 79,
        "publication_id_list": "10216261;10216262;10235266;10542397;11121022;11237011;11865025;12077349;12144530;12177000;12774125;14500761;15175151;15192080;15192092;15716272;15896744;15923626;15961505;16223362;16751179;16912044;17020914;17081983;17105732;17184956;17218271;17314004;17681692;17717077;18669648;19041634;19211567;19522012;19692572;19850744;19864602;19955185;20159957;20719936;21467194;21979916;22930759;23283970;23546875;24223135;24715725;25114211;26154972;26758079;29493099;30429286;31154438;31428396;31844290;31922365;32157095;32366965;32387766;32938616;32983136;33585677;33912179;33968037;34185709;34509645;35051231;35580925;36241641;36284347;37651006;37938771;37961948;38066638;38474099;38570607;7706727;7877627;9653119",
        "class_list": "",
        "function": "A role of NR4A2 in Graves' disease: regulation of Th17/Treg., [RefSeq, PubMed]; Evaluation of mRNA Expressions of TOX and NR4As in CD8+ T cells in Acute Leukemia., [RefSeq, PubMed]; Orphan Nuclear Receptor Family 4A (NR4A) Members NR4A2 and NR4A3 Selectively Modulate Elements of the Monocyte Response to Buffered Hypercapnia. Publication Status: Online-Only, [RefSeq, PubMed]; The nuclear receptor Nurr1 is preferentially expressed in human pro-inflammatory macrophages and limits their inflammatory profile., [RefSeq, PubMed]; This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development (PubMed:15716272, PubMed:17184956). It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB]; Unveiling the methionine cycle: a key metabolic signature and NR4A2 as a methionine-responsive oncogene in esophageal squamous cell carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
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        "predicted_o_glycosites": 2,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "reported_snv": 20,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16311;Q53RZ2;Q6NXU0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding;GO:0046982 protein heterodimerization activity;GO:0035259 nuclear glucocorticoid receptor binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016607 nuclear speck;GO:0005667 transcription regulator complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0001764 neuron migration",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "P43354-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y3F4-1",
        "uniprot_id": [
            {
                "id": "STRAP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y3F4",
                "type": "external"
            }
        ],
        "mass": 38438.0,
        "length": 350,
        "protein_name": "Serine-threonine kinase receptor-associated protein",
        "gene_name": "STRAP",
        "organism": "Human",
        "refseq_name": "serine-threonine kinase receptor-associated protein",
        "refseq_ac": [
            {
                "id": "NP_009109",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009109",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "STRAP; MAWD; UNRIP",
        "gene_names_refseq": "MAWD; PT-WD; STRAP; UNRIP",
        "protein_names_uniprotkb": "Serine-threonine kinase receptor-associated protein; MAP activator with WD repeats; UNR-interacting protein; WD-40 repeat protein PT-WD",
        "protein_names_refseq": "MAP activator with WD repeats; MAPK activator with WD repeats; WD-40 repeat protein PT-WD; mitogen-activated protein kinase activator with WD repeats; serine-threonine kinase receptor-associated protein; unr-interacting protein",
        "tax_id": 9606,
        "disease": "colorectal carcinoma (Disease Ontology:DOID:0080199); adenocarcinoma (Disease Ontology:DOID:299); squamous cell neoplasm (Disease Ontology:DOID:3168); lung carcinoma (Disease Ontology:DOID:3905); large cell carcinoma (Disease Ontology:DOID:4552)",
        "pathway": " (hsa:11171);  (R-HSA-2173788);  (R-HSA-9764790)",
        "pathway_count": 3,
        "publication_count": 137,
        "publication_id_list": "10049359;10519551;10646843;10757800;11158580;11163210;11230166;11237011;11278251;12151385;12519765;14701756;14718519;15496141;15781469;15848170;16027725;16061177;16159890;16251192;17178713;18669648;18984161;19758997;19880523;20061380;20129061;20305658;20937913;21740066;21872626;22045334;22344298;22424782;23186163;23301498;23481700;24275569;24715725;25418920;25485581;25576301;25645385;25810538;26154972;26754738;26758079;26811146;26929215;26992070;27600516;27846572;27862975;28218747;28228285;28352266;28514659;28649982;28832583;28834231;28904123;29186683;29242379;29331515;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30206221;30315122;30410026;30429286;30484775;30542730;30779550;31020640;31154438;31217245;31222486;31844290;31848261;31957176;31998317;32119511;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33214551;33298915;33537174;33592498;33633747;33691108;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34211107;34229054;34357683;34405274;34509645;34520730;34725712;35051231;35138101;35251023;35272839;35561310;35580925;36010968;36215666;36241641;36284347;36420658;36580660;37340703;37938771;38665916;40596516;40914422;9215638;9335507;9856985",
        "class_list": "",
        "function": "Serine-Threonine Kinase Receptor Associate Protein (STRAP) confers an aggressive phenotype in neuroblastoma via regulation of Focal Adhesion Kinase (FAK)., [RefSeq, PubMed]; Serine-threonine Kinase Receptor-Associated Protein is a Critical Mediator of APC Mutation-Induced Intestinal Tumorigenesis Through a Feed-Forward Mechanism., [RefSeq, PubMed]; The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. Most spliceosomal snRNPs contain a common set of Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (Sm core). In the cytosol, the Sm proteins SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG are trapped in an inactive 6S pICln-Sm complex by the chaperone CLNS1A that controls the assembly of the core snRNP. To assemble core snRNPs, the SMN complex accepts the trapped 5Sm proteins from CLNS1A forming an intermediate. Binding of snRNA inside 5Sm triggers eviction of the SMN complex, thereby allowing binding of SNRPD3 and SNRPB to complete assembly of the core snRNP. STRAP plays a role in the cellular distribution of the SMN complex. Negatively regulates TGF-beta signaling but positively regulates the PDPK1 kinase activity by enhancing its autophosphorylation and by significantly reducing the association of PDPK1 with 14-3-3 protein., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "B2R5S5;B4DNJ6;Q5TZT4;Q9NTK0;Q9UQC8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0005102 signaling receptor binding;GO:1990447 U2 snRNP binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0032797 SMN complex;GO:0034719 SMN-Sm protein complex",
        "go_biological_process": "GO:0030154 cell differentiation;GO:0030277 maintenance of gastrointestinal epithelium;GO:0030512 negative regulation of transforming growth factor beta receptor signaling pathway;GO:0000387 spliceosomal snRNP assembly;GO:0000380 alternative mRNA splicing, via spliceosome",
        "synthesized_glycan_count": 0,
        "hit_score": 14.0,
        "record_id": "Q9Y3F4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6NZ67-1",
        "uniprot_id": [
            {
                "id": "MZT2B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6NZ67",
                "type": "external"
            }
        ],
        "mass": 16226.0,
        "length": 158,
        "protein_name": "Mitotic-spindle organizing protein 2B",
        "gene_name": "MZT2B",
        "organism": "Human",
        "refseq_name": "mitotic-spindle organizing protein 2B isoform 2",
        "refseq_ac": [
            {
                "id": "NP_079305",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079305",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MZT2B; FAM128B; MOZART2B",
        "gene_names_refseq": "FAM128B; MOZART2B; MZT2B",
        "protein_names_uniprotkb": "Mitotic-spindle organizing protein 2B; Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B",
        "protein_names_refseq": "family with sequence similarity 128, member B; mitotic-spindle organizing protein 2B isoform 2; mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80097);  (R-HSA-380270);  (R-HSA-380320)",
        "pathway_count": 3,
        "publication_count": 45,
        "publication_id_list": "11237011;11956313;12221128;16462731;19651622;19690332;20068231;20360068;22424782;23481700;23921553;24715725;26154972;27846572;29393594;29493099;29557506;29632046;31373491;31844290;32157095;32265295;32387766;32488085;32502341;32610146;32897882;32938616;32983136;33141586;33691108;33968037;34211107;34357683;34509645;35051231;35154160;35561310;35580925;36010968;36241641;39321809;7769006;7790358;8838651",
        "class_list": "",
        "function": "MZT Proteins Form Multi-Faceted Structural Modules in the gamma-Tubulin Ring Complex., [RefSeq, PubMed]; Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:39321809)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 2,
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        "total_reported_o_glycosites": 2,
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        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96CG4",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0000931 gamma-tubulin ring complex",
        "go_biological_process": "GO:0007020 microtubule nucleation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.9,
        "record_id": "Q6NZ67-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WX94-1",
        "uniprot_id": [
            {
                "id": "NALP7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WX94",
                "type": "external"
            }
        ],
        "mass": 111807.0,
        "length": 980,
        "protein_name": "NACHT, LRR and PYD domains-containing protein 7",
        "gene_name": "NLRP7",
        "organism": "Human",
        "refseq_name": "NACHT, LRR and PYD domains-containing protein 7 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001120727",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120727",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NLRP7; NALP7; NOD12; PYPAF3",
        "gene_names_refseq": "CLR19.4; HYDM; NALP7; NLRP7; NOD12; OZEMA25; PAN7; PYPAF3",
        "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 7; Nucleotide-binding oligomerization domain protein 12; PYRIN-containing APAF1-like protein 3",
        "protein_names_refseq": "NACHT, LRR and PYD containing protein 7; NACHT, LRR and PYD domains-containing protein 7 isoform 3; NACHT, LRR and PYD domains-containing protein 7; NACHT, leucine rich repeat and PYD containing 7; PYRIN-containing Apaf1-like protein 3; nucleotide-binding oligomerization domain protein 12; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 7",
        "tax_id": 9606,
        "disease": "gestational trophoblastic neoplasm (Disease Ontology:DOID:3590); oocyte/zygote/embryo maturation arrest 25 (MONDO:MONDO:0980964)",
        "pathway": " (hsa:199713)",
        "pathway_count": 1,
        "publication_count": 42,
        "publication_id_list": "11237011;12019269;12563287;12766759;15817483;16462743;19246479;20547486;22169519;23963444;24714562;24715725;25880248;25892735;26154972;27920218;28218747;28904123;29437277;29557506;30315122;30410026;31530632;31844290;32350084;32357974;32502341;32938616;33298915;33717175;33912179;33936100;34357683;35051231;35251023;35318648;36010968;36544392;36980199;37148315;37273114;39052836",
        "class_list": "",
        "function": "Gene body hypomethylation of pyroptosis-related genes NLRP7, NLRP2, and NLRP3 facilitate non-invasive surveillance of hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; HLA-C expression in extravillous trophoblasts is determined by an ELF3-NLRP2/NLRP7 regulatory axis., [RefSeq, PubMed]; Inhibits CASP1/caspase-1-dependent IL1B secretion., [UniProtKB, PubMed]; NLRP7 Enhances Choriocarcinoma Cell Survival and Camouflage in an Inflammasome Independent Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; NLRP7 participates in the human subcortical maternal complex and its variants cause female infertility characterized by early embryo arrest., [RefSeq, PubMed]; Novo pathogenic variations of NLRP7 increasing the risk of gestational trophoblastic neoplasia., [RefSeq, PubMed]; This gene encodes a member of the NACHT, leucine rich repeat, and PYD containing (NLRP) protein family. It has an N-terminal pyrin domain, followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. NLRP proteins are implicated in the activation of proinflammatory caspases through multiprotein complexes called inflammasomes. This gene may act as a feedback regulator of caspase-1-dependent interleukin 1-beta secretion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PE16;Q32MH8;Q7RTR1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0019966 interleukin-1 binding;GO:0042802 identical protein binding;GO:0019828 aspartic-type endopeptidase inhibitor activity;GO:0089720 caspase binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005938 cell cortex",
        "go_biological_process": "GO:0051293 establishment of spindle localization;GO:0032691 negative regulation of interleukin-1 beta production;GO:0071222 cellular response to lipopolysaccharide;GO:0050727 regulation of inflammatory response;GO:0040019 positive regulation of embryonic development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q8WX94-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86WB0-1",
        "uniprot_id": [
            {
                "id": "ZC3C1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86WB0",
                "type": "external"
            }
        ],
        "mass": 55262.0,
        "length": 502,
        "protein_name": "Zinc finger C3HC-type protein 1",
        "gene_name": "ZC3HC1",
        "organism": "Human",
        "refseq_name": "zinc finger C3HC-type protein 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001269119",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269119",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZC3HC1; HSPC216; NIPA",
        "gene_names_refseq": "HSPC216; NIPA; ZC3HC1",
        "protein_names_uniprotkb": "Zinc finger C3HC-type protein 1; Nuclear-interacting partner of ALK; Nuclear-interacting partner of anaplastic lymphoma kinase; hNIPA",
        "protein_names_refseq": "hematopoietic stem/progenitor cell protein 216; nuclear interacting partner of anaplastic lymphoma kinase (ALK); nuclear-interacting partner of ALK; zinc finger C3HC-type protein 1 isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51530);  (R-HSA-9725371)",
        "pathway_count": 2,
        "publication_count": 91,
        "publication_id_list": "11169414;11237011;11751994;12748172;15302935;15345747;16009132;16964243;17081983;17110082;17111047;17322306;17389604;17416736;17690253;17922009;18024471;18097461;18212344;18220336;18452278;18669648;18691976;18767875;19007248;19413330;19415658;19651622;19664994;19664995;19690332;19691289;20015877;20068231;20166139;20230923;20493732;21406692;21715655;22205987;22223895;22955283;23186163;23481700;24060861;24275569;24286297;24366607;25418920;25576301;25818168;26992070;27226629;27553022;27862975;27920218;28218747;28649982;28832583;28904123;29242379;29437277;29557506;29588546;30315122;30410026;30692217;31366041;31390744;31434245;31530632;31679296;31844290;31848261;32157095;32488085;32938616;33298915;33392160;33592498;33968037;34019948;34087483;34171305;34440706;35051231;35561310;35580925;37074911;40914422;9930702",
        "class_list": "",
        "function": "Data show that cell cycle-dependent phosphorylation of nuclear interaction partner of anaplastic lymphoma kinase (NIPA)is mediated by extracellular signal-regulated kinase 2 (ERK2)., [RefSeq, PubMed]; Data show that common variants in A disintegrin and metalloproteinase with thrombospondin motifs 7 protein (ADAMTS7) and zinc finger, C3HC-type containing 1 protein (ZC3HC1) genes contribute to an increased risk for both coronary artery disease (CAD) and large artery ischemic stroke (LA atherosclerotic) IS., [RefSeq, PubMed]; NIPA has an antiapoptotic role in NPM-ALK-mediated signaling events, [RefSeq, PubMed]; Phosphorylated NIPA is degraded in late mitosis in an APC/C(Cdh1)-dependent manner, [RefSeq, PubMed]; Required for proper positioning of a substantial amount of TPR at the nuclear basket (NB) through interaction with TPR., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Results indicate that ZC3HC1 rs11556924 polymorphism is associated with subclinical atherosclerosis in rheumatoid arthritis. Publication Status: Online-Only, [RefSeq, PubMed]; The NIPA protein is a human F-box-containing protein that defines an SCF-type E3 ligase (SCF(NIPA)) controlling mitotic entry., [RefSeq, PubMed]; This gene encodes an F-box-containing protein that is a component of an SCF-type E3 ubiquitin ligase complex that regulates the onset of cell division. The G2/M transition in the cell cycle requires the interaction of the proteins cyclin B1 and cyclin-dependent kinase 1. The activated ubiquitin ligase complex targets the protein cyclin B1 for degradation, preventing this transition to mitosis. [provided by RefSeq, Aug 2013]., [RefSeq]; ZC3HC1 Is a Novel Inherent Component of the Nuclear Basket, Resident in a State of Reciprocal Dependence with TPR. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 40,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NH66;Q75MF3;Q75MF4;Q8N330;Q96F75;Q9HA34;Q9NVX4;Q9P0R0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0044615 nuclear pore nuclear basket;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane",
        "go_biological_process": "GO:0051301 cell division;GO:0016567 protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 9.7,
        "record_id": "Q86WB0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UQQ1-1",
        "uniprot_id": [
            {
                "id": "NALDL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UQQ1",
                "type": "external"
            }
        ],
        "mass": 80558.0,
        "length": 740,
        "protein_name": "Aminopeptidase NAALADL1",
        "gene_name": "NAALADL1",
        "organism": "Human",
        "refseq_name": "aminopeptidase NAALADL1",
        "refseq_ac": [
            {
                "id": "NP_005459",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005459",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAALADL1; NAALADASEL; NAALADL",
        "gene_names_refseq": "HILAP; I100; NAALADASEL; NAALADL1",
        "protein_names_uniprotkb": "Aminopeptidase NAALADL1; 100 kDa ileum brush border membrane protein; 3.4.11.-; I100; Ileal dipeptidylpeptidase; N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase L",
        "protein_names_refseq": "100 kDa ileum brush border membrane protein; N-acetylated-alpha-linked acidic dipeptidase-like protein; NAALADase L; aminopeptidase NAALADL1; human ileal aminopeptidase; ileal dipeptidylpeptidase; ileal peptidase I100; peptidase homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10004)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "10085079;11237011;25752612;26992070;28832583;29242379;30192525;35051231;35580925;9388249",
        "class_list": "",
        "function": "Aminopeptidase with broad substrate specificity. Has lower activity with substrates that have Asp or Glu in the P2' position, or Pro in the P3' position. Lacks activity with substrates that have both Pro in the P3' position and Asp or Glu in the P2' position (PubMed:25752612). Lacks carboxypeptidase activity. Lacks dipeptidyl-peptidase IV type activity (PubMed:25752612)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Characterization of the protein product of the human NAALADL1 gene, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 31,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9J8A1;C9J964;C9JL35;C9JSN0;O43176",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0042803 protein homodimerization activity;GO:0004180 carboxypeptidase activity;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0016020 membrane;GO:0016324 apical plasma membrane",
        "go_biological_process": "GO:0006508 proteolysis;GO:0043171 peptide catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q9UQQ1-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1000000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00159-1",
        "uniprot_id": [
            {
                "id": "MYO1C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00159",
                "type": "external"
            }
        ],
        "mass": 121682.0,
        "length": 1063,
        "protein_name": "Unconventional myosin-Ic",
        "gene_name": "MYO1C",
        "organism": "Human",
        "refseq_name": "unconventional myosin-Ic isoform a",
        "refseq_ac": [
            {
                "id": "NP_001074248",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001074248",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO1C",
        "gene_names_refseq": "MMI-beta; MMIb; MYO1C; MyoIC; NMI; myr2",
        "protein_names_uniprotkb": "Unconventional myosin-Ic; MMI-beta; MMIb; Myosin I beta",
        "protein_names_refseq": "myosin-I beta; myosin-Ic; nuclear myosin I; unconventional myosin-Ic isoform a; unconventional myosin-Ic",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4641);  (R-HSA-1445148);  (R-HSA-2029482);  (R-HSA-9662360);  (R-HSA-9662361);  (R-HSA-9664422)",
        "pathway_count": 6,
        "publication_count": 180,
        "publication_id_list": "10025409;10219243;10496324;10559936;10724160;10781580;10821263;10878810;10995437;11157975;11163272;11231582;11237011;11276226;11278486;11329366;11340081;11553796;11747816;11804587;11829459;11854399;12055636;12105426;12189515;12213210;12235133;12743368;1314888;14676198;15040784;15452139;15657136;15919790;15971998;16133118;16262445;16546099;16603771;16641196;16702231;16877530;16880201;16880808;17074750;17081983;17188549;17202194;17308335;17369524;17995453;18070890;18391171;18452278;18669648;18767875;19013499;19252894;19415658;19691289;19741094;19955216;20068231;20112406;20631154;20701589;20837646;20937701;21037092;21419341;21454505;21454690;21907143;22736583;23186163;23481700;23675550;24636949;24714562;24715725;2474607;25418920;25469497;2550440;25576301;25645385;26154972;26375851;26853435;26992070;27397612;27600516;27846572;27920218;28063628;28218747;28228285;28514659;28649982;28832583;28834231;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30315122;30379171;30397120;30410026;31217245;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33123756;33141586;33214551;33298915;33392160;33537174;33592498;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34185709;34211107;34357683;34380438;34509645;34561969;34725712;34932366;35051231;35083852;35318648;35494241;35580925;36010968;36241641;36284347;36736950;36781839;37217939;37938771;37953466;38665916;38904753;39112516;39990658;41018975;7848918;8094051;8664345;8809042;8986718;9119401;9600938;9705280;9799231;9843499;9883880;9885284",
        "class_list": "",
        "function": "A noncanonical E3 ubiquitin ligase RNF41-mediated MYO1C stability promotes prostate cancer metastasis by inducing actin remodeling., [RefSeq, PubMed]; Elevation of truncated (48 kDa) form of unconventional myosin 1C in blood serum correlates with severe Covid-19., [RefSeq, PubMed]; Involved in regulation of transcription. Associated with transcriptional active ribosomal genes. Appears to cooperate with the WICH chromatin-remodeling complex to facilitate transcription. Necessary for the formation of the first phosphodiester bond during transcription initiation., [UniProtKB, UniProtKB]; M[6]A-modified circRNA MYO1C participates in the tumor immune surveillance of pancreatic ductal adenocarcinoma through m[6]A/PD-L1 manner. Publication Status: Online-Only, [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. Involved in glucose transporter recycling in response to insulin by regulating movement of intracellular GLUT4-containing vesicles to the plasma membrane. Component of the hair cell's (the sensory cells of the inner ear) adaptation-motor complex. Acts as a mediator of adaptation of mechanoelectrical transduction in stereocilia of vestibular hair cells. Binds phosphoinositides and links the actin cytoskeleton to cellular membranes., [UniProtKB, PubMed]; RAB31 in glioma-derived endothelial cells promotes glioma cell invasion via extracellular vesicle-mediated enrichment of MYO1C., [RefSeq, PubMed]; Recessive variants in MYO1C as a potential novel cause of proteinuric kidney disease., [RefSeq, PubMed]; This gene encodes a member of the unconventional myosin protein family, which are actin-based molecular motors. The protein is found in the cytoplasm, and one isoform with a unique N-terminus is also found in the nucleus. The nuclear isoform associates with RNA polymerase I and II and functions in transcription initiation. The mouse ortholog of this protein also functions in intracellular vesicle transport to the plasma membrane. Multiple transcript variants encoding different isoforms have been found for this gene. The related gene myosin IE has been referred to as myosin IC in the literature, but it is a distinct locus on chromosome 19. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
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        "reported_phosphosites": 17,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4LE56;Q6NVJ7;Q86Y95",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006338 chromatin remodeling;GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030335 positive regulation of cell migration;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 18.3,
        "record_id": "O00159-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15813-1",
        "uniprot_id": [
            {
                "id": "TBCE_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15813",
                "type": "external"
            }
        ],
        "mass": 59346.0,
        "length": 527,
        "protein_name": "Tubulin-specific chaperone E",
        "gene_name": "TBCE",
        "organism": "Human",
        "refseq_name": "tubulin-specific chaperone E isoform a",
        "refseq_ac": [
            {
                "id": "NP_001072983",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001072983",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TBCE",
        "gene_names_refseq": "HRD; KCS1; KCS; PEAMO; TBCE; pac2",
        "protein_names_uniprotkb": "Tubulin-specific chaperone E; Tubulin-folding cofactor E",
        "protein_names_refseq": "tubulin-specific chaperone E isoform a",
        "tax_id": 9606,
        "disease": "hypoparathyroidism-retardation-dysmorphism syndrome (Disease Ontology:DOID:0060348); Kenny-Caffey syndrome type 1 (Disease Ontology:DOID:0080722); hypoparathyroidism (Disease Ontology:DOID:11199); encephalopathy, progressive, with amyotrophy and optic atrophy (MONDO:MONDO:0014968)",
        "pathway": " (hsa:6905);  (R-HSA-389977)",
        "pathway_count": 2,
        "publication_count": 68,
        "publication_id_list": "10.1101/2023.09.13.557529;10831612;11237011;11847227;12389028;18669648;19608861;20068231;20740604;22223895;23186163;23301498;23481700;24366607;24715725;25505266;25576301;25880248;26992070;27600516;27666369;27666374;27846572;27920218;28510447;28583220;28832583;28904123;29242379;29557506;29632711;29774024;29786170;30429286;30524438;30638765;30833945;31530632;31844290;31848261;32157095;32161166;32275946;32357974;32387766;32502341;32897882;32938616;33141586;33298915;33592498;33936100;33968037;33981976;34019948;34171305;34211107;34509645;35051231;35138101;36010968;36215666;36241641;36258138;36284347;40914422;8706133;9265649",
        "class_list": "",
        "function": "Cofactor E is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; Defective proteasome biogenesis into skin fibroblasts isolated from Rett syndrome subjects with MeCP2 non-sense mutations., [RefSeq, PubMed]; Hypoparathyroidism-Retardation-Dysmorphism Syndrome due to a Variant in the Tubulin-Specific Chaperone E Gene as a Cause of Combined Immune Deficiency., [RefSeq, PubMed]; Mutation analysis of the TBCE gene revealed the common 12-bp (155-166del) deletion in three new Sanjad-Sakati syndrome patients from Tunisia. Review article, [RefSeq, PubMed]; TBCE protein was localized in the middle region and in the tail of the sperm while in the oocyte the localization was cytosolic., [RefSeq, PubMed]; Tubulin-folding protein; involved in the second step of the tubulin folding pathway and in the regulation of tubulin heterodimer dissociation. Required for correct organization of microtubule cytoskeleton and mitotic splindle, and maintenance of the neuronal microtubule network., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "total_n_glycosites": 1,
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        "reported_phosphosites": 2,
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        "missing_score": 0,
        "biomarker_type": "",
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        "disease_count": 4,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K8C2;B7Z3P1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051087 protein-folding chaperone binding;GO:0043014 alpha-tubulin binding;GO:0003735 structural constituent of ribosome;GO:0046872 metal ion binding;GO:0004659 prenyltransferase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0005840 ribosome;GO:1990904 ribonucleoprotein complex;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0006457 protein folding;GO:0000226 microtubule cytoskeleton organization;GO:0007021 tubulin complex assembly;GO:0007052 mitotic spindle organization;GO:0007023 post-chaperonin tubulin folding pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "Q15813-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86UQ8-1",
        "uniprot_id": [
            {
                "id": "NFE4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86UQ8",
                "type": "external"
            }
        ],
        "mass": 19019.0,
        "length": 179,
        "protein_name": "Transcription factor NF-E4",
        "gene_name": "NFE4",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "NFE4",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Transcription factor NF-E4",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "11003662;15084587;15273251;16263792;30379171;33141586",
        "class_list": "",
        "function": "Functions as part of the SSP (stage selector protein) complex, a complex that contributes to the preferential expression of the gamma-gene in fetal erythroid cells by facilitating the interaction of the gamma-globin genes with enhancer elements contained in the locus control region (LCR). The complex binds to the stage selector element (SSE) in the proximal gamma-globin promoter. In contrast, isoform 2 acts as a repressor of gamma-globin gene expression by preventing NFE2 and RNA polymerase II recruitment to the promoter., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
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        "total_reported_o_glycosites": 1,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0003712 transcription coregulator activity;GO:0140297 DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription;GO:0065003 protein-containing complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q86UQ8-1",
        "record_type": "protein",
        "filter_code": "0000000.0100100.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H6R4-1",
        "uniprot_id": [
            {
                "id": "NOL6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H6R4",
                "type": "external"
            }
        ],
        "mass": 127593.0,
        "length": 1146,
        "protein_name": "Nucleolar protein 6",
        "gene_name": "NOL6",
        "organism": "Human",
        "refseq_name": "nucleolar protein 6 isoform alpha",
        "refseq_ac": [
            {
                "id": "NP_075068",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_075068",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NOL6",
        "gene_names_refseq": "NOL6; NRAP; UTP22; bA311H10.1",
        "protein_names_uniprotkb": "Nucleolar protein 6; Nrap; Nucleolar RNA-associated protein",
        "protein_names_refseq": "nucleolar RNA-associated protein; nucleolar protein 6 (RNA-associated); nucleolar protein 6 isoform alpha; nucleolar protein family 6 (RNA-associated)",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:65083);  (R-HSA-6790901);  (R-HSA-6791226)",
        "pathway_count": 3,
        "publication_count": 136,
        "publication_id_list": "10606270;11081632;11237011;11895476;11922599;11935223;11978965;12068309;12150911;12417735;12429849;15199136;16037817;16043514;16381836;16565220;16738141;16782898;17189298;17353269;17412707;17636026;18065403;18438418;18452278;18669648;19007248;19033376;19106111;19332556;19413330;19463982;19564402;19664995;19691289;19801658;20038530;20047967;20056613;20068231;20531386;20798176;20805244;20819938;21036871;21063389;21097556;21406692;22072790;22190735;22195017;22645359;22916032;23186163;23301498;23391857;23439679;23481700;23482395;2388630;24086612;24366607;24424021;24550520;24715725;25411247;25418920;25525153;25576301;25645385;25653167;25851604;25969445;26085946;26154972;26196125;26237581;26811146;26992070;27084949;27846572;27862975;27920218;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29769354;29786170;30315122;30429286;30524438;31217245;31844290;32157095;32265295;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33199730;33298915;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34405274;34516797;34561331;34607487;34725712;34932366;35051231;35580925;36010968;36215666;36241641;40914422;9211966;9482744;9512526",
        "class_list": "",
        "function": "NOL6 promotes the proliferation and migration of endometrial cancer cells by regulating TWIST1 expression., [RefSeq, PubMed]; Nucleolar protein 6 promotes cell proliferation and acts as a potential novel prognostic marker for hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; The nucleolus is a dense subnuclear membraneless organelle that assembles around clusters of rRNA genes and functions in ribosome biogenesis. This gene encodes a nucleolar RNA-associated protein that is highly conserved between species. RNase treatment of permeabilized cells indicates that the nucleolar localization is RNA dependent. Further studies suggest that the protein is associated with ribosome biogenesis through an interaction with pre-rRNA primary transcripts. Alternative splicing has been observed at this locus and two splice variants encoding distinct isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
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        "missing_score": 0,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T5M3;Q5T5M4;Q7L4G6;Q8N6I0;Q8TEY9;Q8TEZ0;Q8TEZ1;Q9H675",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0000794 condensed nuclear chromosome;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0032040 small-subunit processome;GO:0032545 CURI complex",
        "go_biological_process": "GO:0006409 tRNA export from nucleus;GO:0006364 rRNA processing;GO:0042274 ribosomal small subunit biogenesis;GO:0030490 maturation of SSU-rRNA",
        "synthesized_glycan_count": 0,
        "hit_score": 13.9,
        "record_id": "Q9H6R4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZNJ1-1",
        "uniprot_id": [
            {
                "id": "NBEL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZNJ1",
                "type": "external"
            }
        ],
        "mass": 302517.0,
        "length": 2754,
        "protein_name": "Neurobeachin-like protein 2",
        "gene_name": "NBEAL2",
        "organism": "Human",
        "refseq_name": "neurobeachin-like protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_055990",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055990",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NBEAL2; KIAA0540; PRO290",
        "gene_names_refseq": "BDPLT4; GPS; NBEAL2",
        "protein_names_uniprotkb": "Neurobeachin-like protein 2",
        "protein_names_refseq": "neurobeachin-like protein 2 isoform 1; neurobeachin-like protein 2",
        "tax_id": 9606,
        "disease": "gray platelet syndrome (Disease Ontology:DOID:0111044)",
        "pathway": " (hsa:23218);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 107,
        "publication_id_list": "11237011;12975309;18669648;18691976;19367581;19651622;19690332;20058876;20068231;21765411;21765412;21765413;22299025;22424782;22544926;22645359;23186163;23481700;23650620;24714562;24715725;25418920;25576301;25645385;25892735;26154972;26375851;26728094;26811146;26992070;27600516;27846572;27920218;28063628;28082341;28218747;28228285;28514659;28649982;28832583;28834231;28855257;28860189;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29769354;29786170;30315122;30410026;30429286;30524438;31217245;31844290;32157095;32350084;32357974;32384141;32387766;32488085;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33300270;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34405274;34509645;34932366;35051231;35132862;35254053;35494241;35561310;35580925;35705054;36010968;36215666;36241641;36284347;37340703;37349339;38253038;38272677;39534244;40136647;8692836",
        "class_list": "",
        "function": "Gray platelet syndrome: NBEAL2 mutations are associated with pathology beyond megakaryocyte and platelet function defects., [RefSeq, PubMed]; Mutations in NBEAL2, encoding a BEACH protein is associated with gray platelet syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; NBEAL2 deficiency in humans leads to low CTLA-4 expression in activated conventional T cells. Publication Status: Online-Only, [RefSeq, PubMed]; NBEAL2 mutation is associated with gray platelet syndrome. Publication Status: Online-Only, [RefSeq, PubMed, PubMed]; Observational study of gene-disease association and gene-gene interaction. (HuGE Navigator), [RefSeq, PubMed]; Probably involved in thrombopoiesis. Plays a role in the development or secretion of alpha-granules, that contain several growth factors important for platelet biogenesis., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The Neurobeachin-like 2 protein (NBEAL2) controls the homeostatic level of the ribosomal protein RPS6 in mast cells., [RefSeq, PubMed]; The endoplasmic reticulum protein SEC22B interacts with NBEAL2 and is required for megakaryocyte alpha-granule biogenesis., [RefSeq, PubMed]; The protein encoded by this gene contains a beige and Chediak-Higashi (BEACH) domain and multiple WD40 domains, and may play a role in megakaryocyte alpha-granule biogenesis. Mutations in this gene are a cause of gray platelet syndrome. [provided by RefSeq, Dec 2011]., [RefSeq]; We herein show a long-distance regulatory region with GATA1 binding sites as being a strong enhancer for NBEAL2 expression., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 10,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 10,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 55,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60288;Q6P994;Q6UX91;Q8NAC9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070821 tertiary granule membrane",
        "go_biological_process": "GO:0030220 platelet formation;GO:0030099 myeloid cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.9,
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        "filter_code": "0000000.1000111.001000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86U38-1",
        "uniprot_id": [
            {
                "id": "NOP9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86U38",
                "type": "external"
            }
        ],
        "mass": 69438.0,
        "length": 636,
        "protein_name": "Nucleolar protein 9",
        "gene_name": "NOP9",
        "organism": "Human",
        "refseq_name": "nucleolar protein 9 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001273296",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273296",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NOP9; C14orf21; KIAA2021",
        "gene_names_refseq": "C14orf21; HP08474; NOP9",
        "protein_names_uniprotkb": "Nucleolar protein 9",
        "protein_names_refseq": "NOP9 nucleolar protein homolog; hypothetical protein HP08474; nucleolar protein 9 isoform 2; nucleolar protein 9; pumilio domain-containing protein C14orf21",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:161424)",
        "pathway_count": 1,
        "publication_count": 55,
        "publication_id_list": "11237011;16959974;17081983;20068231;21406692;23481700;23783831;25645385;26154972;26768311;26992070;28228285;28832583;28855257;28904123;29242379;29331515;29493099;29557506;29786170;30429286;30524438;31154438;31217245;31844290;31848261;31998317;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33392160;33592498;33968037;33981976;34019948;34087483;34171305;34405274;34509645;34561969;35051231;35318648;35580925;36010968;36284347;37938771;40914422",
        "class_list": "",
        "function": "",
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        "reported_phosphosites": 3,
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        "reported_snv": 2,
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        "biomarker_type": "",
        "glycan_count": 1,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MY76;Q8IVF0;Q8TBS6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0030688 preribosome, small subunit precursor;GO:0030686 90S preribosome",
        "go_biological_process": "GO:0000447 endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000472 endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000480 endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000056 ribosomal small subunit export from nucleus",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "Q86U38-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P57082-1",
        "uniprot_id": [
            {
                "id": "TBX4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P57082",
                "type": "external"
            }
        ],
        "mass": 60204.0,
        "length": 545,
        "protein_name": "T-box transcription factor TBX4",
        "gene_name": "TBX4",
        "organism": "Human",
        "refseq_name": "T-box transcription factor TBX4 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001308049",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001308049",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TBX4",
        "gene_names_refseq": "ICPPS; PAPPAS; SPS; TBX4",
        "protein_names_uniprotkb": "T-box transcription factor TBX4; T-box protein 4",
        "protein_names_refseq": "T-box 4; T-box protein 4; T-box transcription factor TBX4 isoform 1; T-box transcription factor TBX4",
        "tax_id": 9606,
        "disease": "ischiocoxopodopatellar syndrome (Disease Ontology:DOID:0111382); arthropathy (Disease Ontology:DOID:381); autosomal recessive amelia (MONDO:MONDO:0011054)",
        "pathway": " (hsa:9496)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "10945475;11237011;15106123;24038782;27846572;31761294;31844290;32157095;32387766;33392160;33478486;33912179;34509645;35051231;35216193;35580925;36360195;37801629;38191808",
        "class_list": "",
        "function": "Computed tomographic findings in TBX4 mutation: a common cause of severe pulmonary artery hypertension in children. Review article, [RefSeq, PubMed]; Identification and Functional Evaluation of a Novel TBX4 Mutation Underlies Small Patella Syndrome. Publication Status: Online-Only, [RefSeq, PubMed]; Long-Term Effect of TBX4 Germline Mutation on Pulmonary Clinico-Histopathologic Phenotype., [RefSeq, PubMed]; Mutations in the human TBX4 gene cause small patella syndrome, [RefSeq, PubMed]; Potential interactions between the TBX4-FGF10 and SHH-FOXF1 signaling during human lung development revealed using ChIP-seq. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene is the human homolog of mouse Tbx4, which is closely linked to Tbx2 on mouse chromosome 11. Similarly this gene, like TBX2, maps to human chromosome 17. Expression studies in mouse and chicken show that Tbx4 is expressed in developing hindlimb, but not in forelimb buds, suggesting a role for this gene in regulating limb development and specification of limb identity. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptional regulator that has an essential role in the organogenesis of lungs, pelvis, and hindlimbs., [UniProtKB, PubMed]; What Is the Exact Contribution of PITX1 and TBX4 Genes in Clubfoot Development? An Italian Study. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A5PKU7;B2RMT1;B7ZLV3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0003700 DNA-binding transcription factor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0001708 cell fate specification;GO:0001525 angiogenesis;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "P57082-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "B0I1T2-1",
        "uniprot_id": [
            {
                "id": "MYO1G_HUMAN",
                "url": "https://www.uniprot.org/uniprot/B0I1T2",
                "type": "external"
            }
        ],
        "mass": 116442.0,
        "length": 1018,
        "protein_name": "Unconventional myosin-Ig",
        "gene_name": "MYO1G",
        "organism": "Human",
        "refseq_name": "unconventional myosin-Ig",
        "refseq_ac": [
            {
                "id": "NP_149043",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_149043",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO1G; HA2",
        "gene_names_refseq": "HA2; HLA-HA2; MHAG; MYO1G",
        "protein_names_uniprotkb": "Unconventional myosin-Ig",
        "protein_names_refseq": "minor histocompatibility antigen HA-2; myosin-Ig; unconventional myosin-Ig",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64005)",
        "pathway_count": 1,
        "publication_count": 78,
        "publication_id_list": "11237011;11544309;11920221;12601144;14592836;14973499;15031203;16237088;16707472;17241921;18768532;19968988;20058876;20071333;20509834;20653428;22424782;22645359;23022467;24714562;24715725;25576301;25810538;26024233;26154972;26811146;26992070;27397612;27403598;27655845;27846572;27862975;28467828;28904123;29351928;29437277;29493099;29557506;29567312;30429286;31217245;31844290;32157095;32265295;32350084;32357974;32387766;32502341;32897882;32983136;33141586;33298915;33392160;33592498;33633747;33717175;33912179;33936100;33981976;34185709;34211107;34357683;34509645;34561969;34931806;34932366;35051231;35154160;35409272;35561310;35580925;35819746;36215666;36284347;37938771;40307207;40596516;7539551",
        "class_list": "",
        "function": "Activation of MYO1G by lncRNA MNX1-AS1 Drives the Progression in Lung Cancer., [RefSeq, PubMed]; Constitutes the minor histocompatibility antigen HA-2. More generally, minor histocompatibility antigens (mHags) refer to immunogenic peptide which, when complexed with MHC, can generate an immune response after recognition by specific T-cells. The peptides are derived from polymorphic intracellular proteins, which are cleaved by normal pathways of antigen processing. The binding of these peptides to MHC class I or class II molecules and their expression on the cell surface can stimulate T-cell responses and thereby trigger graft rejection or graft-versus-host disease (GVHD) after hematopoietic stem cell transplantation from HLA-identical sibling donor. GVHD is a frequent complication after bone marrow transplantation (BMT), due to mismatch of minor histocompatibility antigen in HLA-matched sibling marrow transplants. HA-2 is restricted to MHC class I HLA-A*0201., [UniProtKB, PubMed]; Detection of Myosin 1g Overexpression in Pediatric Leukemia by Novel Monoclonal Antibodies. Publication Status: Online-Only, [RefSeq, PubMed]; Gene polymorphism does not have any significant effect on the occurrence of GVHD in Tunisia, [RefSeq, PubMed]; MYO1G is a plasma membrane-associated class I myosin (see MIM 601478) that is abundant in T and B lymphocytes and mast cells (Pierce et al., 2001 [PubMed 11544309]; Patino-Lopez et al., 2010 [PubMed 20071333]).[supplied by OMIM, Jun 2010]., [RefSeq]; Maternal-smoking sensitive CpG sites in newborns were significantly associated with rs61087368 SNP located proximal to MYO1G., [RefSeq, PubMed]; Myosin 1G is an abundant class I myosin in lymphocytes whose localization at the plasma membrane depends on its ancient divergent pleckstrin homology (PH) domain, [RefSeq, PubMed]; The information on allele and genotype frequencies of HA-1 and HA-2 in a Taiwanese population, [RefSeq, PubMed]; Unconventional myosin required during immune response for detection of rare antigen-presenting cells by regulating T-cell migration. Unconventional myosins are actin-based motor molecules with ATPase activity and serve in intracellular movements. Acts as a regulator of T-cell migration by generating membrane tension, enforcing cell-intrinsic meandering search, thereby enhancing detection of rare antigens during lymph-node surveillance, enabling pathogen eradication. Also required in B-cells, where it regulates different membrane/cytoskeleton-dependent processes. Involved in Fc-gamma receptor (Fc-gamma-R) phagocytosis., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 2,
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        "biomarker_type": "",
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        "secondary_ac_list": "Q8TEI9;Q8TES2;Q96BE2;Q96RI5;Q96RI6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0005547 phosphatidylinositol-3,4,5-trisphosphate binding;GO:0043325 phosphatidylinositol-3,4-bisphosphate binding",
        "go_cellular_component": "GO:0001891 phagocytic cup;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0015629 actin cytoskeleton;GO:0016020 membrane",
        "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030048 actin filament-based movement;GO:0038096 Fc-gamma receptor signaling pathway involved in phagocytosis;GO:0072678 T cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 8.2,
        "record_id": "B0I1T2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HCI7-1",
        "uniprot_id": [
            {
                "id": "MSL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HCI7",
                "type": "external"
            }
        ],
        "mass": 62541.0,
        "length": 577,
        "protein_name": "E3 ubiquitin-protein ligase MSL2",
        "gene_name": "MSL2",
        "organism": "Human",
        "refseq_name": "E3 ubiquitin-protein ligase MSL2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001138889",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138889",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MSL2; KIAA1585; MSL2L1; RNF184",
        "gene_names_refseq": "KBHS; MSL-2; MSL2L1; MSL2; RNF184",
        "protein_names_uniprotkb": "E3 ubiquitin-protein ligase MSL2; 2.3.2.27; MSL-2; MSL2-like 1; Male-specific lethal 2-like 1; Male-specific lethal-2 homolog 1; Male-specific lethal-2 homolog; RING finger protein 184",
        "protein_names_refseq": "E3 ubiquitin-protein ligase MSL2 isoform 2; E3 ubiquitin-protein ligase MSL2; E3 ubiquitin-protein transferase MSL2; MSL2-like 1; male-specific lethal 2 homolog; male-specific lethal 2-like 1; male-specific lethal-2 homolog 1; ring finger protein 184",
        "tax_id": 9606,
        "disease": "Karayol-Borroto-Haghshenas neurodevelopmental syndrome (MONDO:MONDO:0975836)",
        "pathway": " (hsa:55167);  (R-HSA-3214847)",
        "pathway_count": 2,
        "publication_count": 54,
        "publication_id_list": "10786633;10821277;11237011;15313887;16227571;16387653;16543150;18381289;18452278;18623064;19033443;19187765;20018852;21726816;23084835;23186163;23874665;25218447;25576301;26992070;27600516;27846572;28218747;28228285;28514659;28832583;28904123;29242379;29437277;29557506;29786170;30192525;30315122;30429286;30524438;30930284;31844290;31848261;32157095;32897882;32938616;32983136;33592498;33837287;33912179;35051231;35561310;35580925;37938771;38702431;38815585;9427644;9558366;9880483",
        "class_list": "",
        "function": "A multisubunit human histone acetylase complex that contains homologs of the Drosophila MSL proteins MOF, MSL1 (hampin A), MSL2, and MSL3 was described. This complex is responsible for histone H4 lysine-16 acetylation of all cellular chromosomes. Erratum:[Mol Cell Biol. 2006 Jan;26(1):387], [RefSeq, PubMed]; MSL2 variants lead to a neurodevelopmental syndrome with lack of coordination, epilepsy, specific dysmorphisms, and a distinct episignature., [RefSeq, PubMed]; Non-catalytic component of the MSL histone acetyltransferase complex, a multiprotein complex that mediates the majority of histone H4 acetylation at 'Lys-16' (H4K16ac), an epigenetic mark that prevents chromatin compaction (PubMed:16543150, PubMed:33837287). The MSL complex is required for chromosome stability and genome integrity by maintaining homeostatic levels of H4K16ac (PubMed:33837287). The MSL complex is also involved in gene dosage by promoting up-regulation of genes expressed by the X chromosome (By similarity). X up-regulation is required to compensate for autosomal biallelic expression (By similarity). The MSL complex also participates in gene dosage compensation by promoting expression of Tsix non-coding RNA (By similarity). MSL2 plays a key role in gene dosage by ensuring biallelic expression of a subset of dosage-sensitive genes, including many haploinsufficient genes (By similarity). Acts by promoting promoter-enhancer contacts, thereby preventing DNA methylation of one allele and creating a methylation-free environment for methylation-sensitive transcription factors such as SP1, KANSL1 and KANSL3 (By similarity). Also acts as an E3 ubiquitin ligase that promotes monoubiquitination of histone H2B at 'Lys-35' (H2BK34Ub), but not that of H2A (PubMed:21726816, PubMed:30930284). This activity is greatly enhanced by heterodimerization with MSL1 (PubMed:21726816, PubMed:30930284). H2B ubiquitination in turn stimulates histone H3 methylation at 'Lys-4' (H3K4me) and 'Lys-79' (H3K79me) and leads to gene activation, including that of HOXA9 and MEIS1 (PubMed:21726816). Also involved in the DNA damage response by mediating ubiquitination of TP53/p53 and TP53BP1 (PubMed:19033443, PubMed:23874665)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Novel protein-truncating variants of a chromatin-modifying gene MSL2 in syndromic neurodevelopmental disorders., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "reported_mutagensis": 1,
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        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "glyco_site_count": 0,
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        "secondary_ac_list": "B4DYL4;G5E9I1;Q0D2P1;Q8NDB4;Q9NVS4",
        "ec_number_list": [
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0061630 ubiquitin protein ligase activity;GO:0140585 promoter-enhancer loop anchoring activity;GO:0141054 histone H2B ubiquitin ligase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0072487 MSL complex",
        "go_biological_process": "GO:0006974 DNA damage response;GO:0045893 positive regulation of DNA-templated transcription;GO:0016567 protein ubiquitination;GO:0040029 epigenetic regulation of gene expression;GO:0006513 protein monoubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q9HCI7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95298-1",
        "uniprot_id": [
            {
                "id": "NDUC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95298",
                "type": "external"
            }
        ],
        "mass": 14188.0,
        "length": 119,
        "protein_name": "NADH dehydrogenase [ubiquinone] 1 subunit C2",
        "gene_name": "NDUFC2",
        "organism": "Human",
        "refseq_name": "NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001190983",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001190983",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NDUFC2; HLC1",
        "gene_names_refseq": "B14.5b; CI-B14.5b; HLC-1; MC1DN36; NADHDH2; NDUFC2",
        "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 subunit C2; CI-B14.5b; Complex I-B14.5b; HLC-1; Human lung cancer oncogene 1 protein; NADH-ubiquinone oxidoreductase subunit B14.5b",
        "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 2, 14.5kDa; NADH dehydrogenase [ubiquinone] 1 subunit C2 isoform 2; NADH dehydrogenase [ubiquinone] 1 subunit C2; NADH-ubiquinone oxidoreductase subunit B14.5b; complex I subunit B14.5b; complex I-B14.5b; human lung cancer oncogene 1 protein",
        "tax_id": 9606,
        "disease": "stroke (Disease Ontology:DOID:0051061); nuclear type mitochondrial complex I deficiency (Disease Ontology:DOID:0112065); mitochondrial complex I deficiency, nuclear type 36 (MONDO:MONDO:0030902)",
        "pathway": " (hsa:4718);  (R-HSA-611105);  (R-HSA-6798695);  (R-HSA-6799198)",
        "pathway_count": 4,
        "publication_count": 133,
        "publication_id_list": "10327278;11220739;11230166;11237011;11695836;12231006;12611891;12837546;1327877;14741580;15250827;16230336;17033964;17936786;186667;19064571;19531498;19752196;20112406;20406883;20552642;20858599;20877624;21136679;21509594;21924235;22645359;22869377;23150584;23270816;23553477;23564345;23650620;23747254;23783831;239860;24029068;24191001;24714562;24715725;25418920;25469497;25564869;25576301;25645385;25678554;25802875;25892735;26154972;26375851;26728094;26758079;26992070;27397612;27499296;27543614;27600516;27626371;27846572;27862975;27920218;28063628;28218747;28228285;28832583;28834231;28904123;29242379;29314611;29331515;29371260;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30001391;30315122;30410026;30429286;30484775;30779550;31154438;31611695;31666358;31844290;31848261;31866046;31998317;32157095;32265295;32320651;32357974;32488085;32502341;32897882;32938616;32969598;32983136;33123756;33141586;33392160;33537174;33592498;33633747;33717175;33879611;33882309;34185709;34433824;34932366;35051231;35318648;35333655;35561310;35580925;35614220;36010968;36215666;36241641;36284347;37506315;37558995;37938771;38199007;4288886;8692836;9571201;9878551",
        "class_list": "",
        "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed]; Bi-allelic pathogenic variants in NDUFC2 cause early-onset Leigh syndrome and stalled biogenesis of complex I., [RefSeq, PubMed]; NDUFC2 deficiency exacerbates endothelial mesenchymal transformation during ischemia-reperfusion via NLRP3., [RefSeq, PubMed]; NDUFC2 gene expression is decreased in both classic and follicular variants of papillary thyroid carcinoma., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Polymorphic variants at NDUFC2, encoding a mitochondrial complex I subunit, associate with cardiac hypertrophy in human hypertension. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PNU8;E9PRB2;Q549M5;Q6FIH8;Q9UBJ9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005886 plasma membrane;GO:0035577 azurophil granule membrane",
        "go_biological_process": "GO:1903427 negative regulation of reactive oxygen species biosynthetic process;GO:2001171 positive regulation of ATP biosynthetic process;GO:0032981 mitochondrial respiratory chain complex I assembly;GO:1901223 negative regulation of non-canonical NF-kappaB signal transduction;GO:0010918 positive regulation of mitochondrial membrane potential",
        "synthesized_glycan_count": 0,
        "hit_score": 13.4,
        "record_id": "O95298-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N8Q9-1",
        "uniprot_id": [
            {
                "id": "NIPA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N8Q9",
                "type": "external"
            }
        ],
        "mass": 39185.0,
        "length": 360,
        "protein_name": "Magnesium transporter NIPA2",
        "gene_name": "NIPA2",
        "organism": "Human",
        "refseq_name": "magnesium transporter NIPA2 isoform a",
        "refseq_ac": [
            {
                "id": "NP_001008860",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008860",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NIPA2",
        "gene_names_refseq": "NIPA2; SLC57A2",
        "protein_names_uniprotkb": "Magnesium transporter NIPA2; Non-imprinted in Prader-Willi/Angelman syndrome region protein 2",
        "protein_names_refseq": "magnesium transporter NIPA2 isoform a; magnesium transporter NIPA2; non imprinted in Prader-Willi/Angelman syndrome 2; non-imprinted in Prader-Willi/Angelman syndrome region protein 2",
        "tax_id": 9606,
        "disease": "hereditary spastic paraplegia (Disease Ontology:DOID:2476)",
        "pathway": " (hsa:81614);  (R-HSA-5223345)",
        "pathway_count": 2,
        "publication_count": 86,
        "publication_id_list": "10571941;11237011;11326272;11326338;11401429;12297987;12297989;12951058;13130483;14508708;14984739;15804357;16982806;17166836;18057121;18347014;1840603;18930737;19262752;1955075;19717468;22119785;22367439;22649030;23169667;24725410;24790029;25347071;25469497;25576301;26154972;26620797;26635246;26824658;26992070;27102039;27600516;28218747;28228285;28467828;28514659;28832583;29242379;29314611;29317506;29437277;29557506;29632046;29632711;30315122;30410026;30833945;31003774;31154438;31844290;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32938616;33141586;33298915;33392160;33717175;33912179;33936100;33968037;34171305;34357683;34509645;34561969;34932366;35051231;35251023;35318648;35580925;37938771;4018271;7615546;7619062;7749638;9114041;9537412",
        "class_list": "",
        "function": "AGEs dose-dependently down-regulated the expression of NIPA2 in osteoblasts. NIPA2 also regulated osteoblast apoptosis by affecting the intracellular magnesium level and further affecting the osteogenic capacity of osteoblasts., [RefSeq, PubMed]; Acts as a selective Mg(2+) transporter., [UniProtKB, PubMed]; Located in the genomic domain between break points 1 and 2 on chromosome 15, of the Prader-Willi/Angelman syndromes, [RefSeq, PubMed]; Mutations in NIPA2 gene were associated with childhood absence epilepsy (CAE), which indicated that the haploinsufficiency of NIPA2 might be a candidate mechanism underlying the IGE/CAE phenotypes caused by 15q11.2 microdeletions or rare mutations in NIPA2, [RefSeq, PubMed]; Quantitated mRNA levels of NIPA2, NIPA2,l CYFIP1, and GCP5 in Prader-Willi syndrome and correlated levels with psychological and behavior scales, [RefSeq, PubMed]; This gene encodes a possible magnesium transporter. This gene is located adjacent to the imprinted domain in the Prader-Willi syndrome deletion region of chromosome 15. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene are found on chromosomes 3, 7 and 21.[provided by RefSeq, May 2010]., [RefSeq]; This study primarily reveals that a selective magnesium transporter NIPA2 may play a role in the pathogenesis of CAE. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "F8W7Y8;Q96F03;Q9BVS2",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity",
        "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0015693 magnesium ion transport",
        "synthesized_glycan_count": 0,
        "hit_score": 8.7,
        "record_id": "Q8N8Q9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6KC79-1",
        "uniprot_id": [
            {
                "id": "NIPBL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6KC79",
                "type": "external"
            }
        ],
        "mass": 316051.0,
        "length": 2804,
        "protein_name": "Nipped-B-like protein",
        "gene_name": "NIPBL",
        "organism": "Human",
        "refseq_name": "nipped-B-like protein isoform B",
        "refseq_ac": [
            {
                "id": "NP_056199",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056199",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NIPBL; IDN3; SCC2",
        "gene_names_refseq": "CDLS1; CDLS; IDN3-B; IDN3; NIPBL; Scc2",
        "protein_names_uniprotkb": "Nipped-B-like protein; Delangin; SCC2 homolog",
        "protein_names_refseq": "Nipped-B homolog; SCC2 homolog; delangin; nipped-B-like protein isoform B; nipped-B-like protein; sister chromatid cohesion 2 homolog",
        "tax_id": 9606,
        "disease": "Cornelia de Lange syndrome 1 (Disease Ontology:DOID:0080505); Cornelia de Lange syndrome (Disease Ontology:DOID:11725); cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:25836);  (R-HSA-2470946)",
        "pathway_count": 2,
        "publication_count": 161,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15146185;15146186;15318302;15882967;16565220;16682347;16802858;16959974;16964243;17081983;17112726;17113138;17322306;17525332;17924679;18077418;18212344;18452278;18491316;18669648;18691976;18707149;18767875;19369195;19413330;19415658;19608861;19651622;19664994;19664995;19690332;19691289;19696148;20058876;20068230;20068231;20124326;20358602;20562864;21406692;21934712;22628566;22898188;23186163;23254390;23481700;23783831;24275569;24714562;24715725;25418920;25447906;25576301;25645385;25880248;25892735;26154972;26375851;26728094;26758079;26768311;26992070;27397612;27600516;27846572;27862975;27920218;28063628;28167679;28218747;28228285;28514659;28832583;28834231;28855257;28860189;28904123;28914604;29237092;29242379;29351928;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30059200;30315122;30379171;30429286;30620550;30779550;30833945;31154438;31217245;31222486;31492838;31530632;31844290;31848261;31998317;32157095;32161166;32265295;32357974;32387766;32409525;32488085;32502341;32574038;32897882;32938616;32983136;33091337;33123756;33141586;33298915;33392160;33592498;33691108;33717175;33836029;33912179;33968037;33981976;34019948;34087483;34171305;34185709;34509645;34846842;34932366;35051231;35132862;35254053;35289036;35318648;35494241;35513511;35580925;35842780;36010968;36241641;36284347;36898992;37217939;37340703;37541260;37938771;38378967;39302247;39531497;39534244;39742660;40307207",
        "class_list": "",
        "function": "Deep intronic NIPBL de novo mutations and differential diagnoses revealed by whole genome and RNA sequencing in Cornelia de Lange syndrome patients., [RefSeq, PubMed]; Different NIPBL requirements of cohesin-STAG1 and cohesin-STAG2. Publication Status: Online-Only, [RefSeq, PubMed]; Identified mutations in one gene, NIPBL, in four sporadic and two familial cases of Cornelia de Lange syndrome, [RefSeq, PubMed]; NIPBL-mediated RAD21 facilitates tumorigenicity by the PI3K pathway in non-small-cell lung cancer. Erratum:[Commun Biol. 2024 Apr 1;7(1):397. doi: 10.1038/s42003-024-06085-w. PMID: 38561443] Publication Status: Online-Only, [RefSeq, PubMed]; Plays an important role in the loading of the cohesin complex on to DNA. Forms a heterodimeric complex (also known as cohesin loading complex) with MAU2/SCC4 which mediates the loading of the cohesin complex onto chromatin (PubMed:22628566, PubMed:28914604). Plays a role in cohesin loading at sites of DNA damage. Its recruitment to double-strand breaks (DSBs) sites occurs in a CBX3-, RNF8- and RNF168-dependent manner whereas its recruitment to UV irradiation-induced DNA damage sites occurs in a ATM-, ATR-, RNF8- and RNF168-dependent manner (PubMed:28167679). Along with ZNF609, promotes cortical neuron migration during brain development by regulating the transcription of crucial genes in this process. Preferentially binds promoters containing paused RNA polymerase II. Up-regulates the expression of SEMA3A, NRP1, PLXND1 and GABBR2 genes, among others (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; This gene encodes the homolog of the Drosophila melanogaster Nipped-B gene product and fungal Scc2-type sister chromatid cohesion proteins. The Drosophila protein facilitates enhancer-promoter communication of remote enhancers and plays a role in developmental regulation. It is also homologous to a family of chromosomal adherins with broad roles in sister chromatid cohesion, chromosome condensation, and DNA repair. The human protein has a bipartite nuclear targeting sequence and a putative HEAT repeat. Condensins, cohesins and other complexes with chromosome-related functions also contain HEAT repeats. Mutations in this gene result in Cornelia de Lange syndrome, a disorder characterized by dysmorphic facial features, growth delay, limb reduction defects, and cognitive disability. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 19,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 19,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 19,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 68,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 105,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 3,
        "glyco_site_count": 22,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6KCD6;Q6N080;Q6ZT92;Q7Z2E6;Q8N4M5;Q9Y6Y3;Q9Y6Y4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003714 transcription corepressor activity;GO:0042826 histone deacetylase binding;GO:0070087 chromo shadow domain binding;GO:1990841 promoter-specific chromatin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0070062 extracellular exosome;GO:0000785 chromatin;GO:0032039 integrator complex",
        "go_biological_process": "GO:0061010 gallbladder development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling;GO:0006351 DNA-templated transcription;GO:0050890 cognition",
        "synthesized_glycan_count": 0,
        "hit_score": 18.8,
        "record_id": "Q6KC79-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.001000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P29401-1",
        "uniprot_id": [
            {
                "id": "TKT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P29401",
                "type": "external"
            }
        ],
        "mass": 67878.0,
        "length": 623,
        "protein_name": "Transketolase",
        "gene_name": "TKT",
        "organism": "Human",
        "refseq_name": "transketolase isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001055",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001055",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TKT",
        "gene_names_refseq": "HEL-S-48; HEL107; SDDHD; TKT1; TKT; TK",
        "protein_names_uniprotkb": "Transketolase; 2.2.1.1; TK",
        "protein_names_refseq": "epididymis luminal protein 107; epididymis secretory protein Li 48; transketolase isoform 1",
        "tax_id": 9606,
        "disease": "transketolase deficiency (MONDO:MONDO:0014881)",
        "pathway": " (hsa:7086);  (R-HSA-163754);  (R-HSA-71336);  (R-HSA-9818028)",
        "pathway_count": 4,
        "publication_count": 176,
        "publication_id_list": "10.1101/2023.09.13.557529;10518023;10869557;11237011;11283793;12234984;12665801;14988808;15302935;15592455;1567394;17145369;17585908;17804405;18186520;18560757;18669648;18775706;19273602;19608861;19664995;19690332;20068231;20112406;20667822;20923965;21775727;22682222;22789539;22869377;22965115;23186163;23301498;23481700;23965678;24714562;24715725;24981175;25229427;25418920;25576301;25645385;25810538;2581946;25880248;25892735;26154972;26374642;26375851;26728094;26758079;26768311;26811146;26853435;26929215;26992070;27259054;27397612;27452731;27600516;27846572;27862975;27920218;28063628;28228285;28467828;28514659;28649982;28832583;28834231;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29563135;29632046;29632711;29769354;29786170;29789417;30192525;30315122;30397120;30410026;30484775;30524438;30779550;30833945;31154438;31217245;31222486;31530632;31534226;31717259;31844290;31848261;31989830;31998317;32119511;32157095;32161166;32162841;32265295;32284348;32303435;32336239;32350084;32357974;32373127;32387766;3248678;32488085;32502341;32582032;32649885;32839604;32897882;32938616;32983136;33123756;33141586;33214551;33298915;33392160;33592498;33691108;33717175;33859744;33912179;33936100;33968037;33981976;34019948;34087483;34161071;34171305;34185709;34211107;34357683;34509645;34561969;34725712;34932366;35051231;35083852;35110545;35138101;35154160;35251023;35289036;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37217939;37938771;38216672;38665916;3932573;3994686;40596516;40914422;41016576;7396409;8300619;8419340;9115179;9357955;9920387",
        "class_list": "",
        "function": "Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate (PubMed:20667822, PubMed:27259054, PubMed:31534226). Thus, catalyzes the reversible transfer of a two-carbon ketol group from sedoheptulose-7-phosphate to glyceraldehyde-3-phosphate, producing xylulose-5-phosphate and ribose-5-phosphate (PubMed:20667822, PubMed:27259054, PubMed:31534226). The phosphate group of the substrate plays a role in stabilizing the substrate-thiamine intermediate while preventing the formation of the reactive enamine intermediate (Ref.28). Can also use fructose-6-phosphate as a ketose donor (Probable)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; QM/MM Study of Human Transketolase: Thiamine Diphosphate Activation Mechanism and Complete Catalytic Cycle., [RefSeq, PubMed]; TKT-PARP1 axis induces radioresistance by promoting DNA double-strand break repair in hepatocellular carcinoma., [RefSeq, PubMed]; The crystal structure of human transketolase and new insights into its mode of action., [RefSeq, PubMed]; This gene encodes a thiamine-dependent enzyme which plays a role in the channeling of excess sugar phosphates to glycolysis in the pentose phosphate pathway. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Apr 2012]., [RefSeq]; Transketolase promotes colorectal cancer metastasis through regulating AKT phosphorylation. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K089;B4DE31;E7EPA7;Q8TBA3;Q96HH3",
        "ec_number_list": [
            {
                "id": "2.2.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.2.1.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0042803 protein homodimerization activity;GO:0005509 calcium ion binding;GO:0030976 thiamine pyrophosphate binding;GO:0004802 transketolase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005777 peroxisome;GO:0005829 cytosol;GO:0016607 nuclear speck;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0009052 pentose-phosphate shunt, non-oxidative branch;GO:0006098 pentose-phosphate shunt;GO:0046166 glyceraldehyde-3-phosphate biosynthetic process;GO:1901159 D-xylulose 5-phosphate biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 18.3,
        "record_id": "P29401-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5JTV8-1",
        "uniprot_id": [
            {
                "id": "TOIP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5JTV8",
                "type": "external"
            }
        ],
        "mass": 66248.0,
        "length": 583,
        "protein_name": "Torsin-1A-interacting protein 1",
        "gene_name": "TOR1AIP1",
        "organism": "Human",
        "refseq_name": "torsin-1A-interacting protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001254507",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254507",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TOR1AIP1; LAP1",
        "gene_names_refseq": "LAP1B; LAP1C; LAP1; LGMD2Y; TOR1AIP1",
        "protein_names_uniprotkb": "Torsin-1A-interacting protein 1; LAP1B; Lamin-associated protein 1B",
        "protein_names_refseq": "lamin-associated protein 1B; lamina-associated polypeptide 1B; torsin A interacting protein 1; torsin-1A-interacting protein 1 isoform 1",
        "tax_id": 9606,
        "disease": "autosomal recessive limb-girdle muscular dystrophy type 2Y (Disease Ontology:DOID:0110289)",
        "pathway": " (hsa:26092);  (R-HSA-9013405);  (R-HSA-9035034)",
        "pathway_count": 3,
        "publication_count": 128,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11784792;12061773;12577064;15767459;16361107;16777452;16959974;17064668;17081983;17525332;17765681;17916560;18077418;18452278;18669648;18691976;18802091;19159218;19413330;19415658;19651622;19664994;19690332;20058876;20068230;20068231;20166139;20233848;21119010;21406692;22661428;22665057;22869377;23087206;23090970;23096567;23186163;23569223;24102721;24190977;24275569;24275647;24715725;24856141;25461922;25576301;25645385;25668492;25746724;25810538;26154972;26992070;27278019;27452731;27481945;27846572;27852748;28110863;28218747;28486133;28510447;28649982;28832583;28834231;28904123;28947137;29242379;29331515;29351928;29393594;29437277;29493099;29557506;29632046;29632711;29741879;29776664;29786170;30059200;30315122;30410026;30723199;30833945;31154438;31373491;31844290;31848261;31871319;31998317;32055997;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33214551;33298915;33392160;33465208;33592498;33691108;33912179;34019948;34171305;34357683;34846842;35051231;35251023;35254053;35318648;35494241;35580925;36010968;36284347;37074911;37108075;37938771;38665916;40596516;40914422;8945468",
        "class_list": "",
        "function": "All seven patients are homozygous for a nonsense mutation in the TOR1AIP1 gene resulting in the loss of both protein isoforms LAP1B and LAP1C. Publication Status: Online-Only, [RefSeq, PubMed]; LAP1 protein encoded by TOR1AIP1 may play a role in dysferlinopathy pathogenesis, [RefSeq, PubMed]; Molecular cloning of LAP1B & the role of the protein domains in localization of LAP1B to nuclear and endoplasmic reticulum membranes was determined, [RefSeq, PubMed]; Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; TOR1AIP1-Associated Nuclear Envelopathies. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a type 2 integral membrane protein that binds A- and B-type lamins. The encoded protein localizes to the inner nuclear membrane and may be involved in maintaining the attachment of the nuclear membrane to the nuclear lamina during cell division. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Apr 2016]., [RefSeq]; Two novel cases further expand the phenotype of TOR1AIP1-associated nuclear envelopathies., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 9,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 28,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 32,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 10,
        "disease_count": 1,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0A0MSK5;A8K630;B0QZ57;Q5JTV6;Q8IZ65;Q9H8Y6;Q9HAJ1;Q9NV52;Q9Y3X5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051117 ATPase binding;GO:0008092 cytoskeletal protein binding;GO:0001671 ATPase activator activity;GO:0005521 lamin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0031965 nuclear membrane;GO:0005637 nuclear inner membrane",
        "go_biological_process": "GO:0034504 protein localization to nucleus;GO:0032781 positive regulation of ATP-dependent activity;GO:0071763 nuclear membrane organization",
        "synthesized_glycan_count": 0,
        "hit_score": 15.1,
        "record_id": "Q5JTV8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y4B5-1",
        "uniprot_id": [
            {
                "id": "MTCL1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y4B5",
                "type": "external"
            }
        ],
        "mass": 209526.0,
        "length": 1905,
        "protein_name": "Microtubule cross-linking factor 1",
        "gene_name": "MTCL1",
        "organism": "Human",
        "refseq_name": "microtubule cross-linking factor 1 isoform 4",
        "refseq_ac": [
            {
                "id": "NP_056025",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056025",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MTCL1; CCDC165; KIAA0802; SOGA2",
        "gene_names_refseq": "CCDC165; KIAA0802; MTCL1; SOGA2",
        "protein_names_uniprotkb": "Microtubule cross-linking factor 1; Coiled-coil domain-containing protein 165; PAR-1-interacting protein; SOGA family member 2",
        "protein_names_refseq": "PAR-1-interacting protein; SOGA family member 2; coiled-coil domain containing 165; coiled-coil domain-containing protein 165; microtubule cross-linking factor 1 isoform 4; microtubule cross-linking factor 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23255)",
        "pathway_count": 1,
        "publication_count": 53,
        "publication_id_list": "11237011;16964243;17081983;18220336;18649358;18669648;19369195;19690332;20068231;23186163;23481700;23902687;24715725;25576301;25645385;25892735;26768311;26992070;27521566;27846572;27893789;28228285;28657654;28787032;29242379;29351928;29393594;29557506;30379171;30548255;31373491;31844290;32157095;32161166;32387766;32938616;32983136;33587225;33968037;34019948;34087483;34171305;34405274;35051231;35254053;35580925;36010968;36215666;36241641;38127107;38253038;38665916;39531497",
        "class_list": "",
        "function": "Circular RNA MTCL1 targets SMAD3 by sponging miR-145-5p for regulation of cell proliferation and migration in Hirschsprung's disease. Publication Status: Online-Only, [RefSeq, PubMed]; Microtubule-associated factor involved in the late phase of epithelial polarization and microtubule dynamics regulation (PubMed:23902687). Plays a role in the development and maintenance of non-centrosomal microtubule bundles at the lateral membrane in polarized epithelial cells (PubMed:23902687). Required for faithful chromosome segregation during mitosis (PubMed:33587225)., [UniProtKB, PubMed, PubMed]; Microtubule-regulating activity of microtubule crosslinking factor 1 Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Results suggest that the PPP2R5E phosphatase may contribute to microtubule organization by stabilizing MTCL1., [RefSeq, PubMed]; SOGA1 and SOGA2/MTCL1 are CLASP-interacting proteins required for faithful chromosome segregation in human cells., [RefSeq, PubMed]; We propose MTCL1 as a candidate gene for autosomal recessive cerebellar ataxia in humans. In addition, our study confirms the high diagnostic yield of NGS in early-onset cerebellar ataxias, with at least 50% detection rate in our ataxia cohort., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 35,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 44,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PAY7;Q6ZMQ9;Q8IWA9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008017 microtubule binding;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0000922 spindle pole;GO:0005615 extracellular space;GO:0005856 cytoskeleton;GO:0016324 apical plasma membrane;GO:0016328 lateral plasma membrane",
        "go_biological_process": "GO:0007059 chromosome segregation;GO:0010506 regulation of autophagy;GO:0051301 cell division;GO:0090314 positive regulation of protein targeting to membrane;GO:0001578 microtubule bundle formation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.1,
        "record_id": "Q9Y4B5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TBZ2-1",
        "uniprot_id": [
            {
                "id": "MYBPP_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TBZ2",
                "type": "external"
            }
        ],
        "mass": 111926.0,
        "length": 984,
        "protein_name": "MYCBP-associated protein",
        "gene_name": "MYCBPAP",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "MYCBPAP; AMAP1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "MYCBP-associated protein; AMAM-1; AMAP-1; AMY-1-binding protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84073)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11230166;11237011;12151104;18077418;25892735;29242379;29393594;29632046;29731959;39704931",
        "class_list": "",
        "function": "Plays a crucial role in centrosome-nuclear envelope docking during spermiogenesis, a key step for anchoring the centrosome to the nucleus that is essential for proper sperm flagellum biogenesis. Also required for acrosome biogenesis, manchette organization, and spermatid head morphogenesis, contributing to the complete and functional assembly of the sperm flagellum., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A140VK87;A6NHJ3;B4DZQ1;Q8TDV8;Q9H0K0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005543 phospholipid binding;GO:0030276 clathrin binding",
        "go_cellular_component": "GO:0030125 clathrin vesicle coat;GO:1990716 axonemal central apparatus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006897 endocytosis;GO:0007283 spermatogenesis;GO:0007268 chemical synaptic transmission;GO:0030317 flagellated sperm motility;GO:0001675 acrosome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q8TBZ2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15394-1",
        "uniprot_id": [
            {
                "id": "NCAM2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15394",
                "type": "external"
            }
        ],
        "mass": 93046.0,
        "length": 837,
        "protein_name": "Neural cell adhesion molecule 2",
        "gene_name": "NCAM2",
        "organism": "Human",
        "refseq_name": "neural cell adhesion molecule 2 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_004531",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004531",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NCAM2; NCAM21",
        "gene_names_refseq": "NCAM21; NCAM2",
        "protein_names_uniprotkb": "Neural cell adhesion molecule 2; N-CAM-2; NCAM-2",
        "protein_names_refseq": "N-CAM-2; NCAM-2; neural cell adhesion molecule 2 isoform 2 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4685)",
        "pathway_count": 1,
        "publication_count": 31,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12754519;18510355;18706912;20058876;21300289;23090970;24190977;27596683;29391424;29393594;29557506;29741879;29895898;30315122;32043120;32157095;32387766;32938616;33548223;33912179;33968037;34087483;34357683;34433824;34509645;35051231;35580925;37074911;9226371",
        "class_list": "glycogene",
        "function": "In the crystal structure, two Ig domains interact by domain swapping, as the two N-terminal beta-strands are interchanged., [RefSeq, PubMed]; May play important roles in selective fasciculation and zone-to-zone projection of the primary olfactory axons., [UniProtKB, UniProtKB, UniProtKB]; NCAM2 Regulates Dendritic and Axonal Differentiation through the Cytoskeletal Proteins MAP2 and 14-3-3., [RefSeq, PubMed]; Our reported case raises the questions whether the NCAM2-deletion is the true cause of the autism spectrum disorder or only a risk factor and whether there might be any connection in NCAM2 with skull-size, [RefSeq, PubMed]; Spatiotemporal processing of neural cell adhesion molecules 1 and 2 by BACE1 in vivo., [RefSeq, PubMed]; The protein encoded by this gene belongs to the immunoglobulin superfamily. It is a type I membrane protein and may function in selective fasciculation and zone-to-zone projection of the primary olfactory axons. [provided by RefSeq, Jul 2008]., [RefSeq]; These results reveal that the NCAM2 FnIII domains form a rigid structure that binds and activates FGFR in a manner related to, but different from NCAM1. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 10,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 10,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "reported_snv": 1257,
        "reported_interactions": 0,
        "missing_score": 8621,
        "biomarker_type": "",
        "glycan_count": 15,
        "disease_count": 0,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8MQ06;B7Z841;Q7Z7F2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043005 neuron projection;GO:0097060 synaptic membrane",
        "go_biological_process": "GO:0007158 neuron cell-cell adhesion;GO:0007155 cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 5.7,
        "record_id": "O15394-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010001.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96EZ4-1",
        "uniprot_id": [
            {
                "id": "MYEOV_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96EZ4",
                "type": "external"
            }
        ],
        "mass": 33556.0,
        "length": 313,
        "protein_name": "Myeloma-overexpressed gene protein",
        "gene_name": "MYEOV",
        "organism": "Human",
        "refseq_name": "myeloma-overexpressed gene protein isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001280223",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001280223",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYEOV; OCIM",
        "gene_names_refseq": "MYEOV; OCIM",
        "protein_names_uniprotkb": "Myeloma-overexpressed gene protein; Oncogene in multiple myeloma",
        "protein_names_refseq": "14) positive multiple myelomas); myeloma overexpressed (in a subset of t(11; myeloma overexpressed gene (in a subset of t(11; myeloma-overexpressed gene protein isoform 2; myeloma-overexpressed gene protein; oncogene in multiple myeloma",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26579)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "10753852;11237011;12202983;16275643;16552434;29314611;30181549;30620550;32938616;33912179;33968037;34171305;34930894;35051231;36698109;37667096;38490328",
        "class_list": "",
        "function": "Epigenetic inactivation of myeov is associated with esophageal squamous cell carcinomas, [RefSeq, PubMed]; Experiments demonstrated that the MYEOV ceRNA sequestered miR-30c-2-3p from binding its targets TGFBR2 and USP15 mRNAs, which in turn leading to constitutive activation of TGF-beta signaling and tumor progression in Non-small cell lung cancer., [RefSeq, PubMed]; MYEOV overexpression induced by demethylation of its promoter contributes to pancreatic cancer progression via activation of the folate cycle/c-Myc/mTORC1 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; MYEOV protein synthesis is regulated by upstream open reading frames, [RefSeq, PubMed]; MYEOV with High Frequencies of Mutations in Head and Neck Cancers Facilitates Cancer Cell Malignant Behaviors., [RefSeq, PubMed]; Super-enhancer mediated upregulation of MYEOV suppresses ferroptosis in lung adenocarcinoma., [RefSeq, PubMed]; The MYEOV-MYC association promotes oncogenic miR-17/93-5p expression in pancreatic ductal adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The putative role for MYEOV genes may provide important targets for intervention in Gastric adenocarcinoma, evidenced by their role in promoting invasion and proliferation, key phenotypic hallmarks of cancer cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
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        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UGN6;Q9UGN7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q96EZ4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NFY4-1",
        "uniprot_id": [
            {
                "id": "NEMP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NFY4",
                "type": "external"
            }
        ],
        "mass": 48664.0,
        "length": 417,
        "protein_name": "Nuclear envelope integral membrane protein 2",
        "gene_name": "NEMP2",
        "organism": "Human",
        "refseq_name": "nuclear envelope integral membrane protein 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001136117",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136117",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NEMP2; TMEM194B",
        "gene_names_refseq": "NEMP2; TMEM194B",
        "protein_names_uniprotkb": "Nuclear envelope integral membrane protein 2",
        "protein_names_refseq": "UPF0571 transmembrane protein; nuclear envelope integral membrane protein 2 precursor; transmembrane protein 194B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100131211)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "11237011;22424782;23481700;25418920;25576301;25892735;26992070;27893789;28218747;28228285;28832583;28904123;29242379;29437277;29632046;31844290;32157095;32387766;32502341;32897882;32938616;33691108;33912179;34211107;34509645;34561969;35051231",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DYG6",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005637 nuclear inner membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "A6NFY4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5VY43-1",
        "uniprot_id": [
            {
                "id": "PEAR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5VY43",
                "type": "external"
            }
        ],
        "mass": 110666.0,
        "length": 1037,
        "protein_name": "Platelet endothelial aggregation receptor 1",
        "gene_name": "PEAR1",
        "organism": "Human",
        "refseq_name": "platelet endothelial aggregation receptor 1 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001073940",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073940",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PEAR1; MEGF12",
        "gene_names_refseq": "JEDI; MEGF12; PEAR1",
        "protein_names_uniprotkb": "Platelet endothelial aggregation receptor 1; Multiple EGF-like domains protein 12; Multiple epidermal growth factor-like domains protein 12; hPEAR1",
        "protein_names_refseq": "multiple EGF-like domains protein 12; multiple EGF-like-domains 12; multiple epidermal growth factor-like domains protein 12; platelet endothelial aggregation receptor 1 isoform 1 precursor",
        "tax_id": 9606,
        "disease": "neurodegenerative disease (Disease Ontology:DOID:1289); myopathy (Disease Ontology:DOID:423)",
        "pathway": " (hsa:375033)",
        "pathway_count": 1,
        "publication_count": 16,
        "publication_id_list": "11237011;15851471;18511696;19429868;20526338;21791418;28832583;30429286;30459171;34075782;36241641;36436185;36792666;38299390;38665916;38728491",
        "class_list": "",
        "function": "A specific intronic PEAR1 gene variant is ientified that associated with greater platelet aggregability and protein expression., [RefSeq, PubMed]; C allele of PEAR1 (Platelet endothelial aggregation receptor-1)was generally associated in both ethnic groups with increased aggregation of native platelets GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Effect of PEAR1, PTGS1 gene polymorphisms on the recurrence of aspirin-treated patients with ischemic stroke in the Han population of China: A 4-year follow-up study., [RefSeq, PubMed]; Genetic Polymorphisms of GP1BA, PEAR1, and PAI-1 may be Associated with Serum sIgE and Blood Eosinophil Levels in Chinese Patients with Allergic Diseases., [RefSeq, PubMed]; Genetic variants of PEAR1 and ischemic clinical outcomes in coronary artery disease patients: a systematic review and meta-analysis., [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; PEAR1 is a novel platelet receptor that signals secondary to alpha(IIb)beta(3)-mediated platelet-platelet contacts, [RefSeq, PubMed]; PEAR1 is a platelet receptor that signals upon the formation of platelet-platelet contacts independent of platelet activation and secondary to platelet aggregation (Nanda et al., 2005 [PubMed 15851471]).[supplied by OMIM, Mar 2008]., [RefSeq]; PEAR1 is a potential regulator of early hematopoiesis of human pluripotent stem cells., [RefSeq, PubMed]; Required for SVEP1-mediated platelet activation, via its interaction with SVEP1 and subsequent activation of AKT/mTOR signaling (PubMed:36792666). May be involved in the early stages of hematopoiesis (By similarity)., [UniProtKB, UniProtKB, PubMed]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 46,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8TEK2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0038023 signaling receptor activity",
        "go_cellular_component": "GO:0001891 phagocytic cup;GO:0016020 membrane;GO:0030027 lamellipodium;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0070527 platelet aggregation;GO:0043491 phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0010572 positive regulation of platelet activation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.1,
        "record_id": "Q5VY43-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000011001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P21817-1",
        "uniprot_id": [
            {
                "id": "RYR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P21817",
                "type": "external"
            }
        ],
        "mass": 565176.0,
        "length": 5038,
        "protein_name": "Ryanodine receptor 1",
        "gene_name": "RYR1",
        "organism": "Human",
        "refseq_name": "ryanodine receptor 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_000531",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000531",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RYR1; RYDR",
        "gene_names_refseq": "CCO; CMYO1A; CMYO1B; CMYP1A; CMYP1B; KDS; MHS1; MHS; PPP1R137; RYDR; RYR-1; RYR1; RYR; SKRR",
        "protein_names_uniprotkb": "Ryanodine receptor 1; RYR-1; RyR1; Skeletal muscle calcium release channel; Skeletal muscle ryanodine receptor; Skeletal muscle-type ryanodine receptor; Type 1 ryanodine receptor",
        "protein_names_refseq": "central core disease of muscle; protein phosphatase 1, regulatory subunit 137; ryanodine receptor 1 (skeletal); ryanodine receptor 1 isoform 1; sarcoplasmic reticulum calcium release channel; skeletal muscle calcium release channel; skeletal muscle ryanodine receptor; type 1-like ryanodine receptor",
        "tax_id": 9606,
        "disease": "King Denborough syndrome (Disease Ontology:DOID:0080990); congenital myopathy 1B (Disease Ontology:DOID:0080991); pre-eclampsia (Disease Ontology:DOID:10591); gestational diabetes (Disease Ontology:DOID:11714); intracranial vasospasm (Disease Ontology:DOID:13100); primary pulmonary hypertension (Disease Ontology:DOID:14557); alcohol use disorder (Disease Ontology:DOID:1574); osteochondrodysplasia (Disease Ontology:DOID:2256); congenital myopathy 1A (Disease Ontology:DOID:3529); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); malignant hyperthermia (Disease Ontology:DOID:8545)",
        "pathway": " (hsa:6261);  (R-HSA-2672351);  (R-HSA-5578775)",
        "pathway_count": 3,
        "publication_count": 254,
        "publication_id_list": "10.1101/2023.09.13.557529;10051009;10097181;10220561;10484775;10564087;10612851;10642508;10720933;10767424;10823104;10830164;10831588;10888602;10913253;11062458;11113224;11182090;11237011;11241852;11389482;11525881;11575529;11588175;11687798;11709545;11734858;11741831;11842292;11904445;11904675;11928716;11956057;12059893;12066726;12112081;12119109;12123492;12136074;12208234;12393854;12411788;12565913;12566385;12629052;12709367;12719381;12832055;12883402;12907679;12937085;12953268;1354642;1379744;14532276;14584882;14634667;14641996;14670767;14732627;14985404;15010458;15044642;15147738;15174025;15221887;15260953;15318163;15448513;15504734;15505377;15598648;15754088;15916532;15919655;16163667;16219661;16380615;1639409;16754674;16813530;16849430;16850186;1693919;17204054;17224452;17226826;17322306;17357072;17381423;17448995;17486119;17699613;1774074;17881003;18000046;18063579;18253926;18268335;18310267;18312400;18318008;18400985;18449189;18508966;18650434;18662336;18724360;18765655;18995841;19153159;19191329;19278978;19307298;19380724;19387438;19620632;19664994;19685112;19751721;19808995;19953639;20142353;20388639;20388710;20466723;20525693;20538786;20583297;20681998;20961976;21040849;21108950;21514828;21527911;21674524;21984732;22002868;22210847;2226863;22427649;22707725;22752422;22773952;22913516;22946059;22972900;2298749;23112050;23173055;2321095;23362265;23481700;23549614;23558838;23610579;23616951;24013571;2430951;24561095;24715725;2477373;2536303;2559024;25645385;25994790;26115329;26359375;26381711;26562072;26631338;27234031;27543614;27586648;27616680;27918309;28071645;28154142;28228285;2838329;28411811;28645727;28790369;28832583;29393594;29508533;2953725;29557506;29786170;29953482;30429286;30484775;30524438;30635368;30779550;31154438;31844290;31848261;32387766;32488085;32502341;32938616;34171305;34509645;35051231;35469018;35494241;35580925;36010968;36215666;36241641;36284347;38520674;39150833;39409197;6328127;7556644;7588753;7665160;7702581;7751854;7795595;7829078;7849712;7881417;7929371;8012359;8041726;8112288;8220422;8220423;8380342;8383669;8533761;8544406;8626462;8661021;8798450;8809036;8918259;9037075;9066328;9138151;9346285;9389851;9395096;9450902;9497245;9571199;9607712;9662395;9700209;9719863;9744806",
        "class_list": "",
        "function": "Compound Heterozygous RYR1 Variants in a Patient with Severe Congenital Myopathy: Case Report and Comparison with Additional Cases of Recessive RYR1-Related Myopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Cytosolic calcium-activated calcium channel that mediates the release of Ca(2+) from the sarcoplasmic reticulum into the cytosol and thereby plays a key role in triggering muscle contraction following depolarization of T-tubules. Repeated very high-level exercise increases the open probability of the channel and leads to Ca(2+) leaking into the cytoplasm. Can also mediate the release of Ca(2+) from intracellular stores in neurons, and may thereby promote prolonged Ca(2+) signaling in the brain. Required for normal embryonic development of muscle fibers and skeletal muscle. Required for normal heart morphogenesis, skin development and ossification during embryogenesis., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Individuals and Families Affected by RYR1-Related Diseases: The Patient/Caregiver Perspective., [RefSeq, PubMed]; Lethal multiple pterygium syndrome, large cystic hygroma, and cleft palate: Rare and severe fetal presentations of RYR1- and NEB-related congenital myopathies., [RefSeq, PubMed]; This gene encodes a ryanodine receptor found in skeletal muscle. The encoded protein functions as a calcium release channel in the sarcoplasmic reticulum but also serves to connect the sarcoplasmic reticulum and transverse tubule. Mutations in this gene are associated with malignant hyperthermia susceptibility, central core disease, and minicore myopathy with external ophthalmoplegia. Alternatively spliced transcripts encoding different isoforms have been described. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 13,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 193,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 13,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16314;Q16368;Q9NPK1;Q9P1U4",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005262 calcium channel activity;GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0005509 calcium ion binding;GO:0015278 intracellularly gated calcium channel activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005790 smooth endoplasmic reticulum;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0043931 ossification involved in bone maturation;GO:0006936 muscle contraction;GO:0051289 protein homotetramerization;GO:0001666 response to hypoxia;GO:0006816 calcium ion transport",
        "synthesized_glycan_count": 0,
        "hit_score": 25.9,
        "record_id": "P21817-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.000100.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P24821-1",
        "uniprot_id": [
            {
                "id": "TENA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P24821",
                "type": "external"
            }
        ],
        "mass": 240853.0,
        "length": 2201,
        "protein_name": "Tenascin",
        "gene_name": "TNC",
        "organism": "Human",
        "refseq_name": "tenascin isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_002151",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002151",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TNC; HXB",
        "gene_names_refseq": "150-225; DFNA56; GMEM; GP; HXB; JI; TN-C; TNC; TN",
        "protein_names_uniprotkb": "Tenascin; Cytotactin; GMEM; GP 150-225; Glioma-associated-extracellular matrix antigen; Hexabrachion; JI; Myotendinous antigen; Neuronectin; TN-C; TN; Tenascin-C",
        "protein_names_refseq": "GP 150-225; cytotactin; deafness, autosomal dominant 56; glioma-associated-extracellular matrix antigen; hexabrachion (tenascin); myotendinous antigen; neuronectin; tenascin isoform 1 precursor; tenascin-C additional domain 1",
        "tax_id": 9606,
        "disease": "polycystic kidney disease (Disease Ontology:DOID:0080322); autosomal dominant nonsyndromic deafness 56 (Disease Ontology:DOID:0110581); asbestosis (Disease Ontology:DOID:10320); pleural tuberculosis (Disease Ontology:DOID:106); allergic conjunctivitis (Disease Ontology:DOID:11204); intracranial vasospasm (Disease Ontology:DOID:13100); lung cancer (Disease Ontology:DOID:1324); pulmonary sarcoidosis (Disease Ontology:DOID:13406); asthma (Disease Ontology:DOID:2841); glioblastoma (Disease Ontology:DOID:3068); high grade glioma (Disease Ontology:DOID:3070); pleural empyema (Disease Ontology:DOID:3798); cholangiocarcinoma (Disease Ontology:DOID:4947); pneumonia (Disease Ontology:DOID:552); myocardial infarction (Disease Ontology:DOID:5844); pulmonary hypertension (Disease Ontology:DOID:6432); extrinsic allergic alveolitis (Disease Ontology:DOID:841)",
        "pathway": " (hsa:3371);  (R-HSA-216083);  (R-HSA-3000170);  (R-HSA-3000178);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 6,
        "publication_count": 237,
        "publication_id_list": "10.1101/2023.09.13.557529;0;10022829;10026136;10077652;10209034;10218588;10339611;10366422;10438935;10512690;10543983;10593924;10605720;10614670;10640428;10673326;10673366;10681634;10713152;10810289;10811134;10898936;10912521;10951195;10982388;10990447;11084047;11158056;11158588;11237011;11250653;11259413;11264294;11316783;11518510;11522292;11572855;11606061;11713259;11739083;11751371;11788658;11980922;12225811;12241545;12379487;12466191;12496264;12585966;12682293;1279805;12807887;12810533;12904166;12975610;1370451;1376317;1383255;14681059;14715956;14976204;15075323;15126567;15240572;15296743;15308688;15330449;15345499;15383545;1544908;15469690;15479743;15485880;15525596;15642270;15713743;1588291;15899827;16002701;16051604;16239428;16293224;16335952;16493581;16731529;16754661;16933105;16945929;1704365;17047378;1707164;1719530;17249697;17312271;17314405;17339034;17588949;17968485;17985932;18578522;18710925;18775695;18780401;19159218;19502598;19884327;20033473;2010551;20166139;2059554;20705068;21642437;21789315;22134916;22539938;22654117;22884367;23090970;23301498;23374253;2364322;23936043;2412224;24190977;2420006;24275569;2430969;2466295;2476804;2479552;25576301;26091039;26992070;27424145;27726376;27846572;28467828;28657654;29308320;29391424;29557506;2963012;29741879;29786170;29789417;30429286;30459171;31844290;32125861;32157095;32387766;32488085;32938616;32983136;33043033;33141586;33507879;33592498;33633747;33968037;34078123;34185709;35051231;35154160;35318648;35494241;35580925;36010968;36213313;36228153;36284347;37074911;37758009;37929694;37938771;37972699;37987507;38471098;38665916;6193777;6439184;7499434;7505120;7519608;7523391;7524681;7525263;7525578;7525634;7525824;7527058;7527330;7531707;7538844;7541634;7542249;7542669;7543116;7559467;7588299;7683646;7685013;7689487;7693733;7852349;8002934;8118028;8344274;8440685;8560266;8609172;8781553;8798654;8817670;8824254;8838667;8894645;8910476;8943283;8964575;9115237;9251239;9252349;9294172;9341124;9346959;9443892;9497324;9565552;9685393;9709957;9733769;9786878;9858236;9922210;9949188",
        "class_list": "glycogene",
        "function": "Association of Tenascin-C Gene Polymorphisms with Risk of Acute Coronary Syndrome in South Indian Population: A Case-Control Genetic Association Study., [RefSeq, PubMed]; Caveolin-1-dependent tenascin C inclusion in extracellular vesicles is required to promote breast cancer cell malignancy., [RefSeq, PubMed]; Characteristics of n6-methyladenosine (m6A) regulators and role of FTO/TNC in scleroderma., [RefSeq, PubMed]; Engrailed 2 serves as a master regulator of the super-enhancer in the TNC gene locus in non-small cell lung cancer., [RefSeq, PubMed]; Extracellular matrix protein implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity as well as neuronal regeneration. Promotes neurite outgrowth from cortical neurons grown on a monolayer of astrocytes. Ligand for integrins alpha-8/beta-1, alpha-9/beta-1, alpha-V/beta-3 and alpha-V/beta-6. In tumors, stimulates angiogenesis by elongation, migration and sprouting of endothelial cells (PubMed:19884327)., [UniProtKB, PubMed]; Tenascin-C-EGFR activation induces functional human satellite cell proliferation and promotes wound-healing of skeletal muscles via oleanic acid., [RefSeq, PubMed]; This gene encodes an extracellular matrix protein with a spatially and temporally restricted tissue distribution. This protein is homohexameric with disulfide-linked subunits, and contains multiple EGF-like and fibronectin type-III domains. It is implicated in guidance of migrating neurons as well as axons during development, synaptic plasticity, and neuronal regeneration. [provided by RefSeq, Jul 2011]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 20,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 15,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 20,
        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 20,
        "total_o_glycosites": 9,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3051,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 202,
        "disease_count": 17,
        "glyco_site_count": 32,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9IYT7;C9J575;C9J6D9;C9J848;Q14583;Q15567;Q5T7S3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding;GO:0045545 syndecan binding;GO:0005201 extracellular matrix structural constituent",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005925 focal adhesion;GO:0016020 membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0030155 regulation of cell adhesion;GO:0009611 response to wounding;GO:0001558 regulation of cell growth;GO:0050727 regulation of inflammatory response",
        "synthesized_glycan_count": 0,
        "hit_score": 46.9,
        "record_id": "P24821-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000010001.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96MN2-1",
        "uniprot_id": [
            {
                "id": "NALP4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96MN2",
                "type": "external"
            }
        ],
        "mass": 113415.0,
        "length": 994,
        "protein_name": "NACHT, LRR and PYD domains-containing protein 4",
        "gene_name": "NLRP4",
        "organism": "Human",
        "refseq_name": "NACHT, LRR and PYD domains-containing protein 4",
        "refseq_ac": [
            {
                "id": "NP_604393",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_604393",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NLRP4; NALP4; PAN2; PYPAF4; RNH2",
        "gene_names_refseq": "CLR19.5; CT58; NALP4; NLRP4; PAN2; PYPAF4; RNH2",
        "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 4; CT58; Cancer/testis antigen 58; PAAD and NACHT-containing protein 2; PAN2; PYPAF4; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; Ribonuclease inhibitor 2",
        "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 4; NACHT, leucine rich repeat and PYD containing 4; PAAD and NACHT-containing protein 2; PYRIN and NACHT-containing protein 2; PYRIN-containing APAF1-like protein 4; cancer/testis antigen 58; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 4; ribonuclease inhibitor 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:147945);  (R-HSA-1606341);  (R-HSA-3134975);  (R-HSA-3270619)",
        "pathway_count": 4,
        "publication_count": 51,
        "publication_id_list": "11035028;11237011;11839743;12093792;12133833;12387869;12563287;12692549;15210742;16281057;16306936;17483521;17526488;17618271;18818105;19307177;19433799;19776740;19926846;21074459;21209283;21862588;22388039;22394562;22579474;22619329;22745133;22928810;23222971;23396211;23481700;24560620;24715725;25892735;26758079;28228285;30315122;30779550;31154438;31844290;31937595;32387766;32983136;33141586;33691108;34257569;34927309;35051231;35467709;35580925;9463386",
        "class_list": "",
        "function": "May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways., [UniProtKB, PubMed, PubMed]; NLRP4 is recruited to and accumulates in bacteria-containing phagosomes and transiently dissociates from beclin1 following group A streptococcus infection, thereby controlling the autophagic flux crucial for cell-autonomous antibacterial resistance., [RefSeq, PubMed]; NLRP4 negatively regulates type I interferon response and influences the outcome in anti-programmed cell death protein (PD)-1/PD-ligand 1 therapy., [RefSeq, PubMed]; Our results provide molecular insight into the mechanisms by which NLRP4-DTX4 targets TBK1 for degradation. Publication Status: Online-Only, [RefSeq, PubMed]; Somatic Mutation of NLRP Genes in Gastric and Colonic Cancers. Publication Status: Online-Only, [RefSeq, PubMed]; The hyper-expression of NLRP4 characterizes the occurrence of macrophage activation syndrome assessing STING pathway in adult-onset Still's disease., [RefSeq, PubMed]; The protein encoded by this gene is a member of the nucleotide-binding and leucine-rich repeat receptor (NLR) family, and is predicted to contain an N-terminal pyrin effector domain (PYD), a centrally-located nucleotide-binding and oligomerization domain (NACHT) and C-terminal leucine-rich repeats (LRR). This gene product has a demonstrated role as a negative regulator of autophagy and type I interferon signaling pathways as a result of protein interactions with its NACHT domain. The PYD domain has also been shown to be important in the inhibition of NF-kB (nuclear factor kappa-light-chain-enhancer of activated B cells). [provided by RefSeq, Dec 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 50,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q86W87;Q96AY6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006954 inflammatory response;GO:0050727 regulation of inflammatory response;GO:0045824 negative regulation of innate immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q96MN2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UQ07-1",
        "uniprot_id": [
            {
                "id": "MOK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UQ07",
                "type": "external"
            }
        ],
        "mass": 48014.0,
        "length": 419,
        "protein_name": "MAPK/MAK/MRK overlapping kinase",
        "gene_name": "MOK",
        "organism": "Human",
        "refseq_name": "MAPK/MAK/MRK overlapping kinase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001258940",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258940",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MOK; RAGE1; RAGE",
        "gene_names_refseq": "MOK; RAGE-1; RAGE1; RAGE; STK30",
        "protein_names_uniprotkb": "MAPK/MAK/MRK overlapping kinase; 2.7.11.22; MOK protein kinase; RAGE-1; Renal tumor antigen 1",
        "protein_names_refseq": "MAPK/MAK/MRK overlapping kinase isoform 2; MAPK/MAK/MRK overlapping kinase; renal cell carcinoma antigen; renal tumor antigen 1",
        "tax_id": 9606,
        "disease": "renal cell carcinoma (Disease Ontology:DOID:4450)",
        "pathway": " (hsa:5891)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "10421840;11237011;15327990;17344846;24244486;24529564;25505266;25755699;30779550;32157095;33639133;35051231;35874702;39894887;8781117",
        "class_list": "",
        "function": "Able to phosphorylate several exogenous substrates and to undergo autophosphorylation. Negatively regulates cilium length in a cAMP and mTORC1 signaling-dependent manner., [UniProtKB, UniProtKB]; Identification of MOK, a member of the mitogen-activated protein kinase superfamily, as one of the genes induced by a caudal-related homeobox transcription factor, Cdx2, [RefSeq, PubMed]; Our results suggest MOK promoter hypomethylation is a common event and contributes to MOK overexpression in acute myeloid leukemia Publication Status: Online-Only, [RefSeq, PubMed]; RAGE silencing deters CML-AGE induced inflammation and TLR4 expression in endothelial cells., [RefSeq, PubMed]; The expressions of ICK/MAK/MOK proteins in the intestinal tract can be differentially and dynamically regulated, implicating a significant functional diversity within this group of protein kinases. Publication Status: Online-Only, [RefSeq, PubMed]; The findings indicate a statistically significant association of p.Gly82Ser polymorphism in RAGE with DR in T2DM patients., [RefSeq, PubMed]; This gene belongs to the MAP kinase superfamily. The gene was found to be regulated by caudal type transcription factor 2 (Cdx2) protein. The encoded protein, which is localized to epithelial cells in the intestinal crypt, may play a role in growth arrest and differentiation of cells of upper crypt and lower villus regions. Multiple alternatively spliced transcript variants encoding different isoforms have been observed for this gene. [provided by RefSeq, Dec 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6Z4;B7Z7P6;E7ER76;E7ERR8;Q92790;Q93067",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
            },
            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
                "type": "external"
            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
                "type": "external"
            },
            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
                "type": "external"
            },
            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
                "type": "external"
            },
            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
                "type": "external"
            },
            {
                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
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            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
                "type": "external"
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            {
                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0004693 cyclin-dependent protein serine/threonine kinase activity;GO:0106310 protein serine kinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005929 cilium;GO:0097546 ciliary base;GO:0005769 early endosome",
        "go_biological_process": "GO:0035556 intracellular signal transduction;GO:0072584 caveolin-mediated endocytosis;GO:2000641 regulation of early endosome to late endosome transport;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0051493 regulation of cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 1.8,
        "record_id": "Q9UQ07-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NQX4-1",
        "uniprot_id": [
            {
                "id": "MYO5C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NQX4",
                "type": "external"
            }
        ],
        "mass": 202810.0,
        "length": 1742,
        "protein_name": "Unconventional myosin-Vc",
        "gene_name": "MYO5C",
        "organism": "Human",
        "refseq_name": "unconventional myosin-Vc",
        "refseq_ac": [
            {
                "id": "NP_061198",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061198",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYO5C",
        "gene_names_refseq": "MYO5C",
        "protein_names_uniprotkb": "Unconventional myosin-Vc",
        "protein_names_refseq": "myosin 5C; myosin-Vc; unconventional myosin-Vc",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55930)",
        "pathway_count": 1,
        "publication_count": 47,
        "publication_id_list": "11237011;11870218;18077418;18079121;18201966;19008234;20068231;25418920;25576301;26758079;26976594;27498562;28218747;28514659;28904123;29242379;29331515;29393594;29557506;29786170;30315122;30410026;30429286;30524438;31698103;31844290;32157095;32357974;32387766;32488085;32938616;33298915;33537174;33592498;33691108;33912179;33968037;33981976;34087483;34171305;34185709;34680964;35051231;35084586;35494241;36010968;36284347",
        "class_list": "",
        "function": "Kinetic simulations reveal that the high ADP affinity of actomyosin Vc may lead to elevations of the duty ratio of myosin Vc to as high as 64% under possible physiological ADP concentrations, [RefSeq, PubMed]; May be involved in transferrin trafficking. Likely to power actin-based membrane trafficking in many physiologically crucial tissues., [UniProtKB]; MyoVc is unique in taking variable size steps, which are frequently in the backward direction. Results obtained with chimeric constructs implicate the lever arm/rod of MyoVc as being responsible for these properties. Actin bundles allow single MyoVc motors to move processively., [RefSeq, PubMed]; Myosin Vc is a low duty ratio nonprocessive motor, [RefSeq, PubMed]; Pendred Syndrome, or Not Pendred Syndrome? That Is the Question. Publication Status: Online-Only, [RefSeq, PubMed]; Related Rab protein, Rab10, can interact with myosin Va, myosin Vb, and myosin Vc, [RefSeq, PubMed]; Spire1 and Myosin Vc promote Ca(2+)-evoked externalization of von Willebrand factor in endothelial cells. Publication Status: Online-Only, [RefSeq, PubMed]; The myosin V structure reveals the detailed rearrangements underlying myosin force generation as well as the basis of strain-dependent ADP release that is essential for processive myosins, such as myosin V., [RefSeq, PubMed]; Unveiling the interaction between the molecular motor Myosin Vc and the small GTPase Rab3A., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6P1W8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003779 actin binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0015629 actin cytoskeleton;GO:0016020 membrane",
        "go_biological_process": "GO:0006897 endocytosis;GO:0007015 actin filament organization;GO:0030050 vesicle transport along actin filament",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q9NQX4-1",
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        "filter_code": "0000000.1000101.010000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P10082-1",
        "uniprot_id": [
            {
                "id": "PYY_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P10082",
                "type": "external"
            }
        ],
        "mass": 11145.0,
        "length": 97,
        "protein_name": "Peptide YY",
        "gene_name": "PYY",
        "organism": "Human",
        "refseq_name": "peptide YY isoform 1 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_001380957",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001380957",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PYY",
        "gene_names_refseq": "PYY-I; PYY1; PYY",
        "protein_names_uniprotkb": "Peptide YY; PYY-II; PYY-I; PYY; Peptide tyrosine tyrosine",
        "protein_names_refseq": "peptide YY isoform 1 preproprotein; peptide tyrosine tyrosine; prepro-PYY",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5697);  (R-HSA-375276);  (R-HSA-418594)",
        "pathway_count": 3,
        "publication_count": 121,
        "publication_id_list": "10079109;10100623;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10604470;10854085;10899166;11007482;11322507;11385580;11457843;11562423;11683476;11773063;12120503;12167864;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15539556;1567413;15947423;15951850;1655761;16634148;16819834;16923326;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18577758;21314817;23446738;23690594;24188711;24906252;2534964;2587421;2649896;2748346;27496565;2834384;29557506;29789417;3202875;3366244;34185709;35180645;3525564;36088864;36525977;37380814;37938771;37995867;3840109;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8015379;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8318545;8373420;8381365;8383682;8395824;8406495;8440682;8463333;8503909;8615752;8666380;8702752;873923;8823230;9171878;9521323;9530155;9593744;9607765;9685625;9722565;9792798;9832121;9851594",
        "class_list": "",
        "function": "Emerging evidence of the relationship between fat-free mass and ghrelin, glucagon-like peptide-1, and peptide-YY. Review article, [RefSeq, PubMed]; Is a NPY2R agonist involved in the down-regulation of appetite and food intake, probably acting on receptors located on proopiomelanocortin(POMC)-releasing and neuropeptide Y(NPY)-releasing neurons in the arcuate nucleus of hypothalamus (PubMed:12167864). In NPY-releasing neurons, NPY2R activation by PYY(3-36) leads to membrane hyperpolarization and reduced release of the orexigenic neuropeptide NPY (By similarity)., [UniProtKB, PubMed, UniProtKB]; Ligand for neuropeptide Y receptor type 1 (NPY1R) and neuropeptide Y receptor type 2 (NPY2R) (PubMed:1317848, PubMed:7592910, PubMed:36525977). Also binds NPY5R (By similarity). Receptor binding induces adenylate cyclase-inhibiting G protein-coupled receptor signaling, resulting in inhibition of cAMP production (PubMed:1317848, PubMed:7592910). Receptor activation by PYY also leads to an increase of intracellular Ca(2+) levels (PubMed:1317848, PubMed:36525977, PubMed:7592910). This gut peptide inhibits exocrine pancreatic secretion (By similarity). Involved in the regulation of colonic antisecretory tone, and colonic contractility (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Peptide YY inhibits transcription and replication of hepatitis B virus by suppressing promoter/enhancer activity., [RefSeq, PubMed]; RET Signaling Persists in the Adult Intestine and Stimulates Motility by Limiting PYY Release From Enteroendocrine Cells., [RefSeq, PubMed]; Structural basis for Y2 receptor-mediated neuropeptide Y and peptide YY signaling., [RefSeq, PubMed]; This gene encodes a member of the neuropeptide Y (NPY) family of peptides. The encoded preproprotein is proteolytically processed to generate two alternative peptide products that differ in length by three amino acids. These peptides, secreted by endocrine cells in the gut, exhibit different binding affinities for each of the neuropeptide Y receptors. Binding of the encoded peptides to these receptors mediates regulation of pancreatic secretion, gut mobility and energy homeostasis. Rare variations in this gene could increase susceptibility to obesity and elevated serum levels of the encoded peptides may be associated with anorexia nervosa. [provided by RefSeq, Feb 2016]., [RefSeq]; We critically discuss recent findings relating to the role of PYY in mediating the beneficial effects of bariatric surgery, the role of PYY in glucose homeostasis, the role of hepatoportal PYY in mediating its central physiological effects--{REVIEW} Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "secondary_ac_list": "Q5U5Q6;Q6FGH8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005184 neuropeptide hormone activity;GO:0005179 hormone activity;GO:0048018 receptor ligand activity;GO:0031841 neuropeptide Y receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:1903999 negative regulation of eating behavior;GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior;GO:0060575 intestinal epithelial cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 12.2,
        "record_id": "P10082-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P02144-1",
        "uniprot_id": [
            {
                "id": "MYG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P02144",
                "type": "external"
            }
        ],
        "mass": 17184.0,
        "length": 154,
        "protein_name": "Myoglobin",
        "gene_name": "MB",
        "organism": "Human",
        "refseq_name": "myoglobin isoform 1",
        "refseq_ac": [
            {
                "id": "NP_005359",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005359",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MB",
        "gene_names_refseq": "MB; MYOSB; PVALB",
        "protein_names_uniprotkb": "Myoglobin; 1.11.1.-; 1.7.-.-; Nitrite reductase MB; Pseudoperoxidase MB",
        "protein_names_refseq": "myoglobin isoform 1; nitrite reductase MB; pseudoperoxidase MB",
        "tax_id": 9606,
        "disease": "COVID-19 (Disease Ontology:DOID:0080600); iron deficiency anemia (Disease Ontology:DOID:11758); hypothyroidism (Disease Ontology:DOID:1459); alcohol use disorder (Disease Ontology:DOID:1574); acute kidney failure (Disease Ontology:DOID:3021); pulmonary hypertension (Disease Ontology:DOID:6432); amphetamine abuse (Disease Ontology:DOID:670); hyperthyroidism (Disease Ontology:DOID:7998); cocaine abuse (Disease Ontology:DOID:809); myopathy, sarcoplasmic body (MONDO:MONDO:0859530)",
        "pathway": " (hsa:4151);  (R-HSA-8981607)",
        "pathway_count": 2,
        "publication_count": 46,
        "publication_id_list": "10360958;11029004;11237011;11429401;11452891;11473128;11893755;11919282;12962627;13584010;14530264;15299006;15601759;18477386;18718500;19919085;20675544;22787149;23160832;23195625;2342104;28904123;29557506;29786170;2989088;30918256;32305557;32450473;32596365;32891753;34671319;34679218;34972240;35527200;36284347;37643191;37759463;4627044;5032105;5285572;5540041;5555219;5555226;5805522;6571704;7895732",
        "class_list": "",
        "function": "Comparative analysis of the myoglobin gene in whales and humans reveals evolutionary changes in regulatory elements and expression levels. Publication Status: Online-Only, [RefSeq, PubMed]; GAPDH is involved in the heme-maturation of myoglobin and hemoglobin., [RefSeq, PubMed]; Monomeric heme protein which primary function is to store oxygen and facilitate its diffusion within muscle tissues. Reversibly binds oxygen through a pentacoordinated heme iron and enables its timely and efficient release as needed during periods of heightened demand (PubMed:30918256, PubMed:34679218). Depending on the oxidative conditions of tissues and cells, and in addition to its ability to bind oxygen, it also has a nitrite reductase activity whereby it regulates the production of bioactive nitric oxide (PubMed:32891753). Under stress conditions, like hypoxia and anoxia, it also protects cells against reactive oxygen species thanks to its pseudoperoxidase activity (PubMed:34679218)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Myoglobin Protects Breast Cancer Cells Due to Its ROS and NO Scavenging Properties. Publication Status: Online-Only, [RefSeq, PubMed]; Myoglobin in Brown Adipose Tissue: A Multifaceted Player in Thermogenesis. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Pseudoperoxidase activity, conformational stability, and aggregation propensity of the His98Tyr myoglobin variant: implications for the onset of myoglobinopathy., [RefSeq, PubMed]; This gene encodes a member of the globin superfamily and is predominantly expressed in skeletal and cardiac muscles. The encoded protein forms a monomeric globular haemoprotein that is primarily responsible for the storage and facilitated transfer of oxygen from the cell membrane to the mitochondria. This protein also plays a role in regulating physiological levels of nitric oxide. Multiple transcript variants encoding distinct isoforms exist for this gene. [provided by RefSeq, May 2020]., [RefSeq]",
        "predicted_glycosites": 0,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "monitoring",
        "glycan_count": 0,
        "disease_count": 10,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q52H51;Q5THY7",
        "ec_number_list": [
            {
                "id": "1.11.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.-",
                "type": "external"
            },
            {
                "id": "1.7.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.7.-.-",
                "type": "external"
            },
            {
                "id": "1.11.1.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.11.1.7",
                "type": "external"
            },
            {
                "id": "1.15.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.15.1.1",
                "type": "external"
            },
            {
                "id": "1.14.12.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.12.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0020037 heme binding;GO:0019825 oxygen binding;GO:0004601 peroxidase activity;GO:0005344 oxygen carrier activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:0016528 sarcoplasm",
        "go_biological_process": "GO:0003009 skeletal muscle contraction;GO:0019430 removal of superoxide radicals;GO:0015671 oxygen transport",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "P02144-1",
        "record_type": "protein",
        "filter_code": "0100000.0000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NV92-1",
        "uniprot_id": [
            {
                "id": "NFIP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NV92",
                "type": "external"
            }
        ],
        "mass": 36390.0,
        "length": 336,
        "protein_name": "NEDD4 family-interacting protein 2",
        "gene_name": "NDFIP2",
        "organism": "Human",
        "refseq_name": "NEDD4 family-interacting protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_061953",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061953",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NDFIP2; KIAA1165; N4WBP5A",
        "gene_names_refseq": "N4WBP5A; NDFIP2",
        "protein_names_uniprotkb": "NEDD4 family-interacting protein 2; NEDD4 WW domain-binding protein 5A; Putative MAPK-activating protein PM04/PM05/PM06/PM07; Putative NF-kappa-B-activating protein 413",
        "protein_names_refseq": "MAPK-activating protein PM04 PM05 PM06 PM07; NEDD4 WW domain-binding protein 5A; NEDD4 family-interacting protein 2 isoform 1; NEDD4 family-interacting protein 2; NF-kappa-B-activating protein 413; putative MAPK-activating protein PM04/PM05/PM06/PM07; putative NF-kappa-B-activating protein 413",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54602)",
        "pathway_count": 1,
        "publication_count": 30,
        "publication_id_list": "11237011;12050153;12761501;12796489;15252135;18077418;18292551;18776082;19343052;20534535;23719902;25418920;25502872;26363003;28228285;28467828;29242379;29317506;29485866;30626607;32161166;32350084;32357974;33392160;33968037;34357683;34433824;35051231;35154160;35251023",
        "class_list": "",
        "function": "Activates HECT domain-containing E3 ubiquitin-protein ligases, including ITCH, NEDD4, NEDD4L, SMURF2, WWP1 and WWP2, and consequently modulates the stability of their targets. As a result, may control many cellular processes. Recruits ITCH, NEDD4 and SMURF2 to endosomal membranes. Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus and multivesicular body where it mediates KCNH2 degradation (PubMed:26363003). May modulate EGFR signaling. Together with NDFIP1, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed]; Data show that membrane protein Ndfip1 recruits E3 ubiquitin (Ub) ligase Nedd4-2 to the Golgi to target ether-a-go-go-related gene (hERG) channel for degradation while membrane protein Ndfip2 also mediates Nedd4-2 interaction with hERG in the Golgi., [RefSeq, PubMed]; N4WBP5A acts as an adaptor to recruit Nedd4 family ubiquitin-protein ligases to the protein trafficking machinery, [RefSeq, PubMed]; N4WBP5A may play a regulatory role in modulating Nedd4 activity at the level of the Golgi apparatus in T lymphocytes, [RefSeq, PubMed]; Role in regulating epithelial sodium channel, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 4,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z2H3;Q7Z428;Q8TAR3;Q9ULQ5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0050699 WW domain binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0007034 vacuolar transport;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0031398 positive regulation of protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q9NV92-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14CX7-1",
        "uniprot_id": [
            {
                "id": "NAA25_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14CX7",
                "type": "external"
            }
        ],
        "mass": 112292.0,
        "length": 972,
        "protein_name": "N-alpha-acetyltransferase 25, NatB auxiliary subunit",
        "gene_name": "NAA25",
        "organism": "Human",
        "refseq_name": "N-alpha-acetyltransferase 25, NatB auxiliary subunit",
        "refseq_ac": [
            {
                "id": "NP_079229",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079229",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAA25; C12orf30; MDM20; NAP1",
        "gene_names_refseq": "C12orf30; MDM20; NAA25; NAP1",
        "protein_names_uniprotkb": "N-alpha-acetyltransferase 25, NatB auxiliary subunit; Mitochondrial distribution and morphology protein 20; N-terminal acetyltransferase B complex subunit MDM20; N-terminal acetyltransferase B complex subunit NAA25; NatB complex subunit MDM20; p120",
        "protein_names_refseq": "N-alpha-acetyltransferase 25, NatB auxiliary subunit; N-terminal acetyltransferase B complex subunit NAA25; mitochondrial distribution and morphology 20; natB complex subunit MDM20",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80018)",
        "pathway_count": 1,
        "publication_count": 67,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;16959974;18570629;19565500;19660095;20068231;23301498;24715725;25418920;25576301;26154972;26600389;26811146;26992070;27600516;27846572;27862975;27920218;28218747;28228285;28832583;28834231;28904123;29242379;29393594;29437277;29557506;29769354;29789417;30315122;30410026;30429286;30524438;30656483;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33592498;33936100;33968037;33981976;34018994;34019948;34230638;34357683;34405274;34509645;34561969;34932366;35051231;35318648;35580925;36010968;36215666;36241641;36284347;37217939;37938771;38253038",
        "class_list": "",
        "function": "Genome-wide long non-coding RNA association study on Han Chinese women identifies lncHSAT164 as a novel susceptibility gene for breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Human N-acetyltransferase complexe NatB consists of human N-acetyltransferase 3 and human MDM20. The hMDM20 knockdown decreased the fraction of cells in G(0)/G(1)-phase and increased the fraction of cells in the sub-G(0)/G(1)-phase. GeneRIF: hMdm20 (C12orf30) is an auxiliary subunit of the human NatB N-terminal acetyltransferase complex while hNat3 (NAT5) is the catalytic subunit. This ribosome associated complex acetylates nascent Met-Asp/Glu- polypeptides., [RefSeq, PubMed]; Mdm20 acts as a novel regulator of Rictor, thereby controlling mTORC2 activity, and leading to the activation of PKCalphaS657 and FoxO1. Publication Status: Online-Only, [RefSeq, PubMed]; Non-catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln. May play a role in normal cell-cycle progression., [UniProtKB, PubMed]; The relationship between the prognosis of children with acute arterial stroke and polymorphisms of CDKN2B, HDAC9, NINJ2, NAA25 genes., [RefSeq, PubMed]; There are associations between juvenile idiopathic arthritis and variants in the TNFAIP3, STAT4, and C12orf30 regions that have previously shown associations with other autoimmune diseases, including rheumatoid arthritis and systemic lupus erythematosus. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes the auxiliary subunit of the heteromeric N-terminal acetyltransferase B complex. This complex acetylates methionine residues that are followed by acidic or asparagine residues.[provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0JLU7;Q6MZH1;Q7Z4N6;Q9H911",
        "ec_number_list": [],
        "go_molecular_function": "GO:0010698 acetyltransferase activator activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031416 NatB complex",
        "go_biological_process": "GO:0007010 cytoskeleton organization",
        "synthesized_glycan_count": 0,
        "hit_score": 7.3,
        "record_id": "Q14CX7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O76024-1",
        "uniprot_id": [
            {
                "id": "WFS1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O76024",
                "type": "external"
            }
        ],
        "mass": 100292.0,
        "length": 890,
        "protein_name": "Wolframin",
        "gene_name": "WFS1",
        "organism": "Human",
        "refseq_name": "wolframin",
        "refseq_ac": [
            {
                "id": "NP_001139325",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001139325",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "WFS1",
        "gene_names_refseq": "CTRCT41; WFRS; WFS1; WFSL; WFS",
        "protein_names_uniprotkb": "Wolframin",
        "protein_names_refseq": "Wolfram syndrome 1 (wolframin); wolframin",
        "tax_id": 9606,
        "disease": "nonsyndromic deafness (Disease Ontology:DOID:0050563); autosomal dominant Wolfram syndrome (Disease Ontology:DOID:0080584); cataract 41 (Disease Ontology:DOID:0110241); autosomal dominant nonsyndromic deafness 6 (Disease Ontology:DOID:0110584); Wolfram syndrome 1 (Disease Ontology:DOID:0110629); optic atrophy 1 (Disease Ontology:DOID:0111441); sensorineural hearing loss (Disease Ontology:DOID:10003); glucose intolerance (Disease Ontology:DOID:10603); Wolfram syndrome (Disease Ontology:DOID:10632); post-traumatic stress disorder (Disease Ontology:DOID:2055); optic atrophy (Disease Ontology:DOID:5723); cataract (Disease Ontology:DOID:83); diabetic retinopathy (Disease Ontology:DOID:8947); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:7466);  (R-HSA-381038);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 4,
        "publication_count": 150,
        "publication_id_list": "10.1101/2023.09.13.557529;10026136;10077652;10218588;10512690;10521293;10601334;10614670;10624825;10679252;10681634;10760554;10810289;10827079;10898936;10912521;10951195;10990447;11158056;11161832;11237011;11250653;11264294;11295831;11316783;11317350;11522292;11606061;11709537;11709538;11739083;11751371;11788658;12181639;12204115;12241545;12379487;12466191;12810533;12904166;1370451;1383255;15126567;15308688;15466936;15469690;15485880;15525596;15605410;15642270;16461360;16539657;16648378;16989814;17047378;17249697;17312271;17492394;17517145;17985932;18518985;18578522;18664523;18688868;20068230;20069065;21282569;21356526;21538838;22226368;22938506;23035048;23186163;23531866;24190977;24462758;2476804;2479552;25388789;26091039;26375851;27862975;28218747;28832583;28834231;28855257;29242379;29557506;29632711;29741879;29769354;29786170;29789417;30315122;30429286;31154438;31844290;31848261;32157095;32161166;32488085;32938616;32983136;33141586;33298915;33912179;33936100;33968037;34087483;34171305;34185709;34725712;35051231;35580925;36010968;36241641;36284347;37074911;37859980;37931151;38665916;38721948;39363032;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7590364;7683646;7689487;8666242;8781553;8817670;8894645;8964575;9037597;9450183;9473480;9497324;9709957;9733769;9771706;9786878;9817917;9922210",
        "class_list": "",
        "function": "Characteristics of autosomal dominant WFS1-associated optic neuropathy and its comparability to OPA1-associated autosomal dominant optic atrophy. Publication Status: Online-Only, [RefSeq, PubMed]; High Frequency of Recessive WFS1 Mutations Among Indian Children With Islet Antibody-negative Type 1 Diabetes., [RefSeq, PubMed]; Novel WFS1 Variants in Two Moroccan Families with Wolfram Syndrome., [RefSeq, PubMed]; Participates in the regulation of cellular Ca(2+) homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca(2+) store (PubMed:16989814). Negatively regulates the ER stress response and positively regulates the stability of V-ATPase subunits ATP6V1A and ATP1B1 by preventing their degradation through an unknown proteasome-independent mechanism (PubMed:23035048)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; The miR-668 binding site variant rs1046322 on WFS1 is associated with obesity in Southeast Asians. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 42,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 14,
        "disease_count": 16,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R797;D3DVT1;Q8N6I3;Q9UNW6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0048306 calcium-dependent protein binding;GO:0051117 ATPase binding;GO:0031625 ubiquitin protein ligase binding;GO:0070628 proteasome binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0030141 secretory granule;GO:0030425 dendrite;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0042048 olfactory behavior;GO:1903892 negative regulation of ATF6-mediated unfolded protein response;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0003091 renal water homeostasis;GO:0043066 negative regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 16.8,
        "record_id": "O76024-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9P253-1",
        "uniprot_id": [
            {
                "id": "VPS18_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9P253",
                "type": "external"
            }
        ],
        "mass": 110186.0,
        "length": 973,
        "protein_name": "Vacuolar protein sorting-associated protein 18 homolog",
        "gene_name": "VPS18",
        "organism": "Human",
        "refseq_name": "vacuolar protein sorting-associated protein 18 homolog",
        "refseq_ac": [
            {
                "id": "NP_065908",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065908",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "VPS18; KIAA1475",
        "gene_names_refseq": "PEP3; VPS18",
        "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 18 homolog; hVPS18",
        "protein_names_refseq": "VPS18, CORVET/HOPS core subunit; hVPS18; vacuolar protein sorting 18 homolog; vacuolar protein sorting protein 18; vacuolar protein sorting-associated protein 18 homolog",
        "tax_id": 9606,
        "disease": "cholestasis (Disease Ontology:DOID:13580)",
        "pathway": " (hsa:57617);  (R-HSA-9754560)",
        "pathway_count": 2,
        "publication_count": 110,
        "publication_id_list": "11237011;11250079;11382755;16203730;16959974;16996030;17081983;17897319;18552835;18669648;18691976;19608861;20434987;21802320;22223895;22424782;23186163;23301498;23351085;23434281;23481700;23901104;24366607;24554770;24714562;24715725;25418920;25576301;25645385;25783203;25880248;25892735;26154972;26728094;26768311;26811146;26992070;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28325809;28514659;28649982;28832583;28834231;28855257;28904123;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30410026;30429286;30484775;30779550;31217245;31530632;31844290;31848261;31937595;31998317;32157095;32350084;32357974;32387766;32502341;32897882;32938616;32983136;33123756;33141586;33298915;33422265;33592498;33717175;33912179;33936100;33947832;33966045;33968037;33981976;34087483;34099617;34171305;34211107;34357683;34386498;34509645;34932366;35051231;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347",
        "class_list": "",
        "function": "HVPS18 may play an important role in regulation of SNK activity through its ubiquitin ligase, [RefSeq, PubMed]; Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes which are proposed to be involved in the Rab5-to-Rab7 endosome conversion probably implicating MON1A/B, and via binding SNAREs and SNARE complexes to mediate tethering and docking events during SNARE-mediated membrane fusion. The HOPS complex is proposed to be recruited to Rab7 on the late endosomal membrane and to regulate late endocytic, phagocytic and autophagic traffic towards lysosomes. The CORVET complex is proposed to function as a Rab5 effector to mediate early endosome fusion probably in specific endosome subpopulations (PubMed:11382755, PubMed:23351085, PubMed:24554770, PubMed:25783203). Required for fusion of endosomes and autophagosomes with lysosomes (PubMed:25783203). Involved in dendrite development of Pukinje cells (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed]; Targeting of VPS18 by the lysosomotropic agent RDN reverses TFE3-mediated drug resistance. Publication Status: Online-Only, [RefSeq, PubMed]; Ubiquitin binding and ubiquitylation of GGA3-GAT domain are mutually inseparable through a ubiquitin ligase activity of hVPS18, [RefSeq, PubMed]; Vesicle mediated protein sorting plays an important role in segregation of intracellular molecules into distinct organelles. Genetic studies in yeast have identified more than 40 vacuolar protein sorting (VPS) genes involved in vesicle transport to vacuoles. This gene encodes the human homolog of yeast class C Vps18 protein. The mammalian class C Vps proteins are predominantly associated with late endosomes/lysosomes, and like their yeast counterparts, may mediate vesicle trafficking steps in the endosome/lysosome pathway. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
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        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8TCG0;Q96DI3;Q9H268",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0019905 syntaxin binding;GO:0061630 ubiquitin protein ligase activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0030897 HOPS complex;GO:0005768 endosome;GO:0005769 early endosome;GO:0005884 actin filament",
        "go_biological_process": "GO:0048284 organelle fusion;GO:0035542 regulation of SNARE complex assembly;GO:0006886 intracellular protein transport;GO:0007032 endosome organization;GO:0007040 lysosome organization",
        "synthesized_glycan_count": 0,
        "hit_score": 11.3,
        "record_id": "Q9P253-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99801-1",
        "uniprot_id": [
            {
                "id": "NKX31_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99801",
                "type": "external"
            }
        ],
        "mass": 26350.0,
        "length": 234,
        "protein_name": "Homeobox protein Nkx-3.1",
        "gene_name": "NKX3-1",
        "organism": "Human",
        "refseq_name": "homeobox protein Nkx-3.1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001243268",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243268",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NKX3-1; NKX3.1; NKX3A",
        "gene_names_refseq": "BAPX2; NKX3-1; NKX3.1; NKX3A; NKX3",
        "protein_names_uniprotkb": "Homeobox protein Nkx-3.1; Homeobox protein NK-3 homolog A",
        "protein_names_refseq": "NK homeobox, family 3, A; NK3 transcription factor homolog A; NK3 transcription factor related, locus 1; homeobox protein NK-3 homolog A; homeobox protein Nkx-3.1 isoform 2; homeobox protein Nkx-3.1",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:4824)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "11137288;11809674;11980664;12972618;16581776;18077445;18757402;19462257;23129228;23890999;25576301;25777618;25892735;28218747;28228285;29508533;29557506;29769354;30429286;30833945;31844290;32157095;32938616;34171305;35051231;36746884;37334663;37893500;38525603;9226374;9377551;9537602",
        "class_list": "",
        "function": "Comprehensive Analysis of NKX3.2 in Liver Hepatocellular Carcinoma by Bigdata. Publication Status: Online-Only, [RefSeq, PubMed]; Fibroblast-derived exosomal microRNA regulates NKX3-1 expression in androgen-sensitive, androgen receptor-dependent prostate cancer cells., [RefSeq, PubMed]; NKX3.1 Expression and Molecular Characterization of Secretory Myoepithelial Carcinoma (SMCA): Advancing the Case for a Salivary Mucous Acinar Phenotype., [RefSeq, PubMed]; NKX3.1 Expression in Non-Prostatic Tumors and Characterizing its Expression in Esophageal/Gastroesophageal Adenocarcinoma. Review article, [RefSeq, PubMed]; This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jan 2012]., [RefSeq]; Transcription factor, which binds preferentially the consensus sequence 5'-TAAGT[AG]-3' and can behave as a transcriptional repressor. Plays an important role in normal prostate development, regulating proliferation of glandular epithelium and in the formation of ducts in prostate. Acts as a tumor suppressor controlling prostate carcinogenesis, as shown by the ability to inhibit proliferation and invasion activities of PC-3 prostate cancer cells., [UniProtKB, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 11,
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        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15465;Q9H2P4;Q9H2P5;Q9H2P6;Q9H2P7;Q9HBG0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0042826 histone deacetylase binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0090734 site of DNA damage",
        "go_biological_process": "GO:0060770 negative regulation of epithelial cell proliferation involved in prostate gland development;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007507 heart development",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q99801-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60293-1",
        "uniprot_id": [
            {
                "id": "ZC3H1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60293",
                "type": "external"
            }
        ],
        "mass": 226356.0,
        "length": 1989,
        "protein_name": "Zinc finger C3H1 domain-containing protein",
        "gene_name": "ZFC3H1",
        "organism": "Human",
        "refseq_name": "zinc finger C3H1 domain-containing protein",
        "refseq_ac": [
            {
                "id": "NP_659419",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_659419",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZFC3H1; CCDC131; KIAA0546; PSRC2",
        "gene_names_refseq": "CCDC131; CSRC2; PSRC2; ZFC3H1",
        "protein_names_uniprotkb": "Zinc finger C3H1 domain-containing protein; Coiled-coil domain-containing protein 131; Proline/serine-rich coiled-coil protein 2",
        "protein_names_refseq": "coiled-coil domain containing 131; coiled-coil domain-containing protein 131; proline/serine-rich coiled-coil 2; proline/serine-rich coiled-coil protein 2; zinc finger C3H1 domain-containing protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:196441);  (R-HSA-9930044)",
        "pathway_count": 2,
        "publication_count": 105,
        "publication_id_list": "11237011;16565220;17174896;17412707;17525332;18452278;18669648;18767875;19007248;19413330;19415658;19651622;19664994;19690332;19691289;20068231;21406692;21705430;21855801;22424782;22645359;23186163;23481700;24366607;24715725;25268596;25505266;25576301;25578728;25892735;26024233;26154972;26992070;27434818;27600516;27846572;27862975;27871484;27920218;28218747;28228285;28649982;28832583;28904123;29242379;29298432;29437277;29493099;29508533;29557506;29605689;29632711;29769354;29906447;30315122;30379171;30429286;31092671;31154438;31217245;31530632;31844290;31848261;31950173;31998317;32157095;32161166;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33633747;33717175;33767452;33912179;33913806;33936100;33968037;34019948;34087483;34171305;34211107;34405274;34509645;34514952;34561969;34932366;35051231;35131366;35494241;35561310;35580925;36010968;36240223;36581221;37217939;37875486;39534244;40596516",
        "class_list": "",
        "function": "PAPgamma associates with PAXT nuclear exosome to control the abundance of PROMPT ncRNAs. Publication Status: Online-Only, [RefSeq, PubMed]; Subunit of the trimeric poly(A) tail exosome targeting (PAXT) complex, a complex that directs a subset of long and polyadenylated poly(A) RNAs for exosomal degradation. The RNA exosome is fundamental for the degradation of RNA in eukaryotic nuclei. Substrate targeting is facilitated by its cofactor MTREX, which links to RNA-binding protein adapters., [UniProtKB, PubMed]; ZFC3H1 participates in the transcriptional activation of IL-8. Erratum:[PLoS One. 2015 Sep 11;10(9):e0138262. doi: 10.1371/journal.pone.0138262. Coin, Fredric [corrected to Coin, Frederic]. PMID: 26360022] Publication Status: Online-Only, [RefSeq, PubMed]; Zinc finger C3H1 domain-containing protein (ZFC3H1) evaluates the prognosis and treatment of prostate adenocarcinoma (PRAD): A study based on TCGA data., [RefSeq, PubMed]; Zinc finger C3H1-type containing serves as a novel prognostic biomarker in human pan-cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
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        "total_o_glycosites": 4,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 36,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 46,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6GMU1;Q6P2S9;Q6ZV36;Q96BE7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:1990477 MTREC complex",
        "go_biological_process": "GO:0006396 RNA processing;GO:0006401 RNA catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.1,
        "record_id": "O60293-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P56278-1",
        "uniprot_id": [
            {
                "id": "MTCP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P56278",
                "type": "external"
            }
        ],
        "mass": 12600.0,
        "length": 107,
        "protein_name": "Protein p13 MTCP-1",
        "gene_name": "MTCP1",
        "organism": "Human",
        "refseq_name": "protein p13 MTCP-1",
        "refseq_ac": [
            {
                "id": "NP_001018025",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001018025",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MTCP1; C6.1B",
        "gene_names_refseq": "MTCP1; P13MTCP1; TCL1C; p8MTCP1",
        "protein_names_uniprotkb": "Protein p13 MTCP-1; MTCP-1 type B1; Mature T-cell proliferation-1 type B1; p13MTCP1",
        "protein_names_refseq": "MTCP-1 type B1; TCL1 family AKT coactivator C; mature T-cell proliferation-1 type B1; protein p13 MTCP-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4515)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "10959629;10983986;11707444;17136114;19064571;29557506;33298915;34732719;8361760;9520380",
        "class_list": "",
        "function": "Enhances the phosphorylation and activation of AKT1 and AKT2., [UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Rare t(X;14)(q28;q32) translocation reveals link between MTCP1 and chronic lymphocytic leukemia. Publication Status: Online-Only, [RefSeq, PubMed]; This gene was identified by involvement in some t(X;14) translocations associated with mature T-cell proliferations. This region has a complex gene structure, with a common promoter and 5' exon spliced to two different sets of 3' exons that encode two different proteins. This gene represents the upstream 13 kDa protein that is a member of the TCL1 family. This protein may be involved in leukemogenesis. [provided by RefSeq, Mar 2009]., [RefSeq]; Transgenic mice overexpressing MTCP1 develop leukemias with a CD8 central memory phenotype in most cases., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5HYP2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0043539 protein serine/threonine kinase activator activity",
        "go_cellular_component": "",
        "go_biological_process": "GO:0035556 intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "P56278-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86UY6-1",
        "uniprot_id": [
            {
                "id": "NAA40_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86UY6",
                "type": "external"
            }
        ],
        "mass": 27194.0,
        "length": 237,
        "protein_name": "N-alpha-acetyltransferase 40",
        "gene_name": "NAA40",
        "organism": "Human",
        "refseq_name": "N-alpha-acetyltransferase 40 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001287729",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001287729",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAA40; NAT11; PATT1",
        "gene_names_refseq": "NAA40; NAT11; NatD; PATT1; hNatD",
        "protein_names_uniprotkb": "N-alpha-acetyltransferase 40; 2.3.1.257; N-acetyltransferase 11; N-alpha-acetyltransferase D; NatD; Protein acetyltransferase 1; hNatD",
        "protein_names_refseq": "N(alpha)-acetyltransferase 40, NatD catalytic subunit, homolog; N-acetyltransferase 11 (GCN5-related, putative); N-alpha acetyl transferase 40; N-alpha-acetyltransferase 40 isoform 2; N-alpha-acetyltransferase D; natD catalytic subunit; protein acetyltransferase 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79829)",
        "pathway_count": 1,
        "publication_count": 36,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;19660095;19695338;21935442;24248912;24397554;25619998;25732826;26666750;26811146;28832583;28904123;29030587;29242379;29331515;29393594;29493099;29557506;29632711;30315122;30779550;30858358;31154438;31844290;32357974;32938616;32983136;33298915;33592498;33691108;34932366;35044762;35580925;36010968;36284347",
        "class_list": "",
        "function": "A novel protein acetyltransferase Patt1 might be involved in the development of hepatocellular carcinoma, [RefSeq, PubMed]; Effects of Oncohistone Mutations and PTM Crosstalk on the N-Terminal Acetylation Activities of NatD., [RefSeq, PubMed]; Findings reveal an anti-apoptotic role for Naa40 and exhibit its potential as a therapeutic target in colorectal cancers., [RefSeq, PubMed]; N-alpha-acetyltransferase that specifically mediates the acetylation of the N-terminal residues of histones H4 and H2A (PubMed:21935442, PubMed:25619998). In contrast to other N-alpha-acetyltransferase, has a very specific selectivity for histones H4 and H2A N-terminus and specifically recognizes the 'Ser-Gly-Arg-Gly sequence' (PubMed:21935442, PubMed:25619998). Acts as a negative regulator of apoptosis (PubMed:26666750). May play a role in hepatic lipid metabolism (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]; NatD-mediated acetylation of histone H4 serine 1 competes with phosphorylation by CK2alpha at the same residue, leading to the upregulation of Slug and lung cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; Results strongly suggest that human Naa40p/NatD is conserved from yeast. Thus, the NATs of all classes of N-terminally acetylated proteins in humans now appear to be accounted for., [RefSeq, PubMed]; The findings strengthen the importance of NAA40 to maintain colorectal cancer cell growth. We show that NAA40 oncogenic properties stimulate the global levels of H4R3me2s by transcriptionally activating PRMT5 methyltransferase which in turn modulates the expression of key downstream cancer-related genes. Publication Status: Online-Only, [RefSeq, PubMed]; The knowledge of detailed molecular architecture of Patt1 is not only the key to understanding its mechanistic functional properties but it also opens the possibility of rational drug and protein design experiments, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 11,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DR03;B4DU10;Q5HYL5;Q9H897",
        "ec_number_list": [
            {
                "id": "2.3.1.257",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.257",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0010485 histone H4 acetyltransferase activity;GO:0043998 histone H2A acetyltransferase activity;GO:1990189 protein N-terminal-serine acetyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.9,
        "record_id": "Q86UY6-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.1000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7RTP0-1",
        "uniprot_id": [
            {
                "id": "NIPA1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7RTP0",
                "type": "external"
            }
        ],
        "mass": 34562.0,
        "length": 329,
        "protein_name": "Magnesium transporter NIPA1",
        "gene_name": "NIPA1",
        "organism": "Human",
        "refseq_name": "magnesium transporter NIPA1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001135747",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135747",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NIPA1; SPG6",
        "gene_names_refseq": "FSP3; NIPA1; SLC57A1; SPG6",
        "protein_names_uniprotkb": "Magnesium transporter NIPA1; Non-imprinted in Prader-Willi/Angelman syndrome region protein 1; Spastic paraplegia 6 protein",
        "protein_names_refseq": "magnesium transporter NIPA1 isoform 2; magnesium transporter NIPA1; non imprinted in Prader-Willi/Angelman syndrome 1; non-imprinted in Prader-Willi/Angelman syndrome region protein 1; spastic paraplegia 6 protein",
        "tax_id": 9606,
        "disease": "hereditary spastic paraplegia 6 (Disease Ontology:DOID:0110811); hereditary spastic paraplegia (Disease Ontology:DOID:2476)",
        "pathway": " (hsa:123606);  (R-HSA-5223345)",
        "pathway_count": 2,
        "publication_count": 57,
        "publication_id_list": "10571941;11237011;11326272;11326338;11401429;12297987;12297989;12805275;12951058;13130483;14508708;14508710;14984739;15643603;15804357;17166836;18057121;18347014;1840603;18930737;19262752;1955075;19717468;22119785;22649030;23169667;24725410;24790029;26620797;26635246;26824658;26992070;27102039;28218747;28228285;29437277;29557506;30315122;30410026;31286297;31530632;31844290;32938616;33633747;33936100;34211107;35051231;36241641;36607129;36736696;38667292;4018271;7615546;7619062;7749638;9114041;9537412",
        "class_list": "",
        "function": "Acts as a Mg(2+) transporter. Can also transport other divalent cations such as Fe(2+), Sr(2+), Ba(2+), Zn(2+) and Co(2+) but to a much less extent than Mg(2+) (By similarity)., [UniProtKB, UniProtKB]; Clinical and genetic characterization of NIPA1 mutations in a Taiwanese cohort with hereditary spastic paraplegia. Review article, [RefSeq, PubMed]; Investigating Repeat Expansions in NIPA1, NOP56, and NOTCH2NLC Genes: A Closer Look at Amyotrophic Lateral Sclerosis Patients from Southern Italy. Publication Status: Online-Only, [RefSeq, PubMed]; LncRNA NIPA1-SO confers atherosclerotic protection by suppressing the transmembrane protein NIPA1., [RefSeq, PubMed]; Located in the genomic domain between break points 1 and 2 on chromosome 15, of the Prader-Willi/Angelman syndromes, [RefSeq, PubMed]; No role of NIPA1 repeat length as a modifier of the C9orf72 ALS disease risk., [RefSeq, PubMed]; This gene encodes a magnesium transporter that associates with early endosomes and the cell surface in a variety of neuronal and epithelial cells. This protein may play a role in nervous system development and maintenance. Multiple transcript variants encoding different isoforms have been found for this gene. Mutations in this gene have been associated with autosomal dominant spastic paraplegia 6. [provided by RefSeq, Nov 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RA76;Q5HYA9;Q7KZB0;Q86XW4",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0015095 magnesium ion transmembrane transporter activity",
        "go_cellular_component": "GO:0005769 early endosome;GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0015693 magnesium ion transport;GO:0055085 transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "Q7RTP0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NC60-1",
        "uniprot_id": [
            {
                "id": "NOA1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NC60",
                "type": "external"
            }
        ],
        "mass": 78458.0,
        "length": 698,
        "protein_name": "Nitric oxide-associated protein 1",
        "gene_name": "NOA1",
        "organism": "Human",
        "refseq_name": "nitric oxide-associated protein 1",
        "refseq_ac": [
            {
                "id": "NP_115689",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115689",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NOA1; C4orf14",
        "gene_names_refseq": "C4orf14; MTG3; NOA1; hAtNOS1; hNOA1; mAtNOS1",
        "protein_names_uniprotkb": "Nitric oxide-associated protein 1",
        "protein_names_refseq": "mitochondrial GTPase 3 homolog; nitric oxide synthase, mitochondrial (putative); nitric oxide-associated protein 1; putative ortholog of Arabidopsis mitochondrial nitric oxide synthase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84273)",
        "pathway_count": 1,
        "publication_count": 42,
        "publication_id_list": "16497976;16959974;18456285;19103604;19690332;20068231;22447445;24715725;25072814;26154972;26992070;27920218;28218747;28228285;28514659;28832583;28904123;29437277;29557506;30315122;30410026;31154438;31844290;32157095;32357974;32387766;32502341;32938616;33141586;33298915;33392160;33691108;33717175;33912179;33936100;33968037;34087483;34357683;34509645;35051231;36010968;36241641",
        "class_list": "",
        "function": "Involved in regulation of mitochondrial protein translation and respiration. Plays a role in mitochondria-mediated cell death. May act as a scaffolding protein or stabilizer of respiratory chain supercomplexes. Binds GTP., [UniProtKB, PubMed]; Our results uncovered an unexpected, mandatory detour of NOA1 through the nucleolus before uptake into mitochondria. Publication Status: Online-Only, [RefSeq, PubMed]; The present study suggests a novel function for mAtNOS1 in regulating mitochondrial nitric oxide and calcium and inducing apoptosis of MCF-7 cells, [RefSeq, PubMed]; The protein encoded by this gene is a nuclear-encoded GTPase that functions in the mitochondrion. Upon translation, this protein is imported into the nucleus and then into the nucleolus before being exported to the mitochondrion. The encoded protein is required for oxygen-dependent regulation of mitochondrial respiratory complexes and for mitochondrial protein synthesis. [provided by RefSeq, Dec 2015]., [RefSeq]; This study indicates rhat C4orf14 is involved in 28S subunit biogenesis and mtDNA maintenance., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8N7L6;Q9BSQ9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005525 GTP binding;GO:0140691 RNA folding chaperone",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0006915 apoptotic process;GO:0007005 mitochondrion organization;GO:0061668 mitochondrial ribosome assembly;GO:0180026 mitochondrial small ribosomal subunit assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 4.3,
        "record_id": "Q8NC60-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P52655-1",
        "uniprot_id": [
            {
                "id": "TF2AA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P52655",
                "type": "external"
            }
        ],
        "mass": 41514.0,
        "length": 376,
        "protein_name": "Transcription initiation factor IIA subunit 1",
        "gene_name": "GTF2A1",
        "organism": "Human",
        "refseq_name": "transcription initiation factor IIA subunit 1 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001265869",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265869",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GTF2A1; TF2A1",
        "gene_names_refseq": "GTF2A1; TF2A1; TFIIA-42; TFIIAL; TFIIA",
        "protein_names_uniprotkb": "Transcription initiation factor IIA subunit 1; General transcription factor IIA subunit 1; TFIIA p19 subunit; TFIIA p35 subunit; TFIIA-42; TFIIAL; Transcription initiation factor TFIIA 42 kDa subunit",
        "protein_names_refseq": "TFIIA alpha/beta subunits; general transcription factor IIA 1; general transcription factor IIA, 1, 19/37kDa; glucose regulated protein, 58kD pseudogene; transcription initiation factor IIA subunit 1 isoform 3; transcription initiation factor IIA subunit 1; transcription initiation factor TFIIA 42 kDa subunit",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2957);  (R-HSA-167161);  (R-HSA-167162);  (R-HSA-167172);  (R-HSA-674695);  (R-HSA-6807505);  (R-HSA-73776);  (R-HSA-73779);  (R-HSA-75953);  (R-HSA-76042);  (R-HSA-9018519)",
        "pathway_count": 11,
        "publication_count": 248,
        "publication_id_list": "10022900;10024882;10199401;10500157;10723029;10828826;10873660;11010967;11030333;11034064;11103799;11136970;11165043;11237011;11278496;11345900;11410592;11433015;11452016;11486021;11581164;11682626;11739720;11784853;11856838;11859374;11884399;12414730;12498683;12574128;12612073;12676794;12959972;1310361;14631847;14675539;14701755;15001666;15257296;15276198;15282324;15343269;15345050;1535687;15489290;15514030;15986123;16009131;16046058;16087863;16113099;16239144;1630819;16308568;16537915;16901896;16959974;16980581;17013392;17081983;17277772;1739980;17463000;17495528;17510434;17637753;17666587;17690249;18079403;18187655;18219272;18256232;1829677;18322535;18358809;18452278;18476782;18533032;18762174;18805503;19001364;19020303;19098913;19274700;19295514;19321454;19383337;1939271;19667075;19718048;20219941;20220130;20457598;20498280;20570965;20682797;21106759;21151129;2125285;21445275;21573489;2181374;21835891;21878914;21934649;21940756;22056668;22137580;22231121;22252320;22265404;22441827;22492511;22545144;22704330;23145106;23166507;23172872;23192763;23301498;23303788;23403292;23435229;23723241;23906331;23932780;24097444;24167369;24270878;24371278;2449431;24735615;24854081;24885040;24973012;24997600;24998469;25296600;25365482;25433557;25542856;25576301;25633194;25663755;25674852;25675981;25728767;26056233;26153859;26204489;26462610;26479350;26992070;27062924;27193682;27600516;27846572;27886276;27893789;28218747;28228285;28539435;28832583;28834231;2919170;29242379;29351928;29437277;2944599;29493099;29508533;29557506;30315122;30410026;30429286;3045126;31154438;31844290;31848261;32157095;32357974;32387766;32488085;32502341;3281094;32897882;32938616;32983136;33298915;33592498;33691108;33968037;34019948;34087483;34561969;34932366;3498214;35051231;35580925;36010968;36241641;3677090;37938771;38665916;39534244;40596516;7151173;7559524;7601352;7660122;7660129;7660130;7715707;7935485;7937828;8156590;8195246;8197458;8224848;8224850;8253082;8330735;8339931;8370526;8419924;8465201;8490964;8628262;8668525;8876171;8946909;9009278;9153304;9188510;9201922;9256425;9338790;9353262;9388265;9405375;9407024;9450929;9489704;9611253;9671459;9705341;9731700;9832505",
        "class_list": "",
        "function": "Accurate transcription initiation on TATA-containing class II genes involves the ordered assembly of RNA polymerase II (POLR2A; MIM 180660) and several general initiation factors (summarized by DeJong and Roeder, 1993 [PubMed 8224848]). One of these factors is TFIIA, which when purified from HeLa extracts consists of 35-, 19-, and 12-kD subunits.[supplied by OMIM, Jul 2010]., [RefSeq]; TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 8,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 16,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3KNQ9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0046982 protein heterodimerization activity;GO:0000979 RNA polymerase II core promoter sequence-specific DNA binding;GO:0017025 TBP-class protein binding;GO:0061629 RNA polymerase II-specific DNA-binding transcription factor binding",
        "go_cellular_component": "GO:0097550 transcription preinitiation complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005672 transcription factor TFIIA complex",
        "go_biological_process": "GO:0060261 positive regulation of transcription initiation by RNA polymerase II;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0006366 transcription by RNA polymerase II;GO:0051123 RNA polymerase II preinitiation complex assembly;GO:0006367 transcription initiation at RNA polymerase II promoter",
        "synthesized_glycan_count": 0,
        "hit_score": 25.9,
        "record_id": "P52655-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N729-1",
        "uniprot_id": [
            {
                "id": "NPW_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N729",
                "type": "external"
            }
        ],
        "mass": 18048.0,
        "length": 165,
        "protein_name": "Neuropeptide W",
        "gene_name": "NPW",
        "organism": "Human",
        "refseq_name": "neuropeptide W preproprotein",
        "refseq_ac": [
            {
                "id": "NP_001092926",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001092926",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NPW; PPL8; PPNPW",
        "gene_names_refseq": "L8C; L8; NPW; PPL8; PPNPW",
        "protein_names_uniprotkb": "Neuropeptide W; Preproprotein L8; hPPL8",
        "protein_names_refseq": "neuropeptide W preproprotein; prepro-neuropeptide W; preproprotein L8",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:283869);  (R-HSA-375276);  (R-HSA-418594)",
        "pathway_count": 3,
        "publication_count": 121,
        "publication_id_list": "10079109;10100623;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10604470;10854085;10899166;11007482;11237011;11322507;11385580;11457843;11562423;11683476;11773063;12120503;12130646;12401809;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15539556;1567413;15947423;15951850;1655761;16634148;16923326;1710450;1710578;1719979;1722333;18127230;18434541;1847994;18577758;22826747;23446738;23690594;24715725;24906252;25270269;25326458;2534964;25576301;2649896;26536090;26992070;2748346;27496565;2834384;30429286;3202875;32350084;3366244;35051231;35251023;3525564;36213313;37453717;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8015379;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8406495;8440682;8463333;8503909;8615752;8666380;8702752;873923;8823230;9171878;9521323;9530155;9593744;9607765;9685625;9722565;9792798;9832121;9851594",
        "class_list": "",
        "function": "A non-AUG translation initiation site is used to express mouse prepro-Npw, [RefSeq, PubMed]; Determined that non-AUG translation initiation is used to express human prepro-NPW, [RefSeq, PubMed]; Our data highlight that NPW modulates the CaV1.2 currents via G protein-coupled receptor 7, and the presence of it influences arterial tone. Erratum:[J Hypertens. 2016 May;34(5):1023. doi: 10.1097/01.hjh.0000482494.85475.78. PMID: 27031934], [RefSeq, PubMed]; Plays a regulatory role in the organization of neuroendocrine signals accessing the anterior pituitary gland. Stimulates water drinking and food intake. May play a role in the hypothalamic response to stress (By similarity). NPW23 activates GPR7 and GPR8 more efficiently than NPW30., [UniProtKB]; The product of this gene is processed into 23- and 30-amino acid neuropeptides that bind and activate two G-protein coupled receptors in the central nervous system. The neuropeptides have been shown to enhance cortisol secretion from adrenal cells through the adenylate cyclase/protein kinase A signaling cascade. The preproprotein is translated using a non-AUG initiation codon that is inferred from analyses of the mouse ortholog. [provided by RefSeq, Jul 2008]., [RefSeq]; These studies indicated an inconsistency between plasma and gastric NPW expression in response to nutrient ingestion, suggesting food induced gastric NPW expression may play a more important role locally, [RefSeq, PubMed]; This review of NPW suggests that study of effects of this peptide may reveal its role in regulating feeding and energy metabolism coupled to leptin levels in the brain. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
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        "reported_snv": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001664 G protein-coupled receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:0007218 neuropeptide signaling pathway;GO:0007631 feeding behavior",
        "synthesized_glycan_count": 0,
        "hit_score": 12.3,
        "record_id": "Q8N729-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P57103-1",
        "uniprot_id": [
            {
                "id": "NAC3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P57103",
                "type": "external"
            }
        ],
        "mass": 103010.0,
        "length": 927,
        "protein_name": "Sodium/calcium exchanger 3",
        "gene_name": "SLC8A3",
        "organism": "Human",
        "refseq_name": "sodium/calcium exchanger 3 isoform G",
        "refseq_ac": [
            {
                "id": "NP_001123889",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123889",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC8A3; NCX3",
        "gene_names_refseq": "NCX3; SLC8A3",
        "protein_names_uniprotkb": "Sodium/calcium exchanger 3; Na(+)/Ca(2+)-exchange protein 3; Solute carrier family 8 member 3",
        "protein_names_refseq": "Na(+)/Ca(2+)-exchange protein 3; sodium/calcium exchanger 3 isoform G; sodium/calcium exchanger 3; sodium/calcium exchanger SLC8A3; solute carrier family 8 (sodium/calcium exchanger), member 3",
        "tax_id": 9606,
        "disease": "Alzheimer's disease (Disease Ontology:DOID:10652); status epilepticus (Disease Ontology:DOID:1824); brain ischemia (Disease Ontology:DOID:2316)",
        "pathway": " (hsa:6547);  (R-HSA-418359);  (R-HSA-425561);  (R-HSA-5578775);  (R-HSA-8949215)",
        "pathway_count": 5,
        "publication_count": 103,
        "publication_id_list": "10220561;10662833;10913253;11062458;11237011;11294880;11904675;12119109;12379639;12406570;12438411;12502570;12558991;12832055;12953268;1374913;14625281;15060069;15174025;15260953;15598648;15754088;15777725;15904662;16357253;16754674;1693919;16959974;17178908;17224452;17357072;17486119;18166528;18452278;18628306;18995841;19278978;19664994;19751721;19797662;20018762;20298697;20388710;20693986;21108950;21685886;21685888;21720385;21959935;22210847;2226863;22427649;22707725;22972900;23362265;23409044;23506867;23549614;23610579;23716663;23755363;23900286;24162235;24231807;2430951;24344246;24503055;24560927;2477373;24898248;25077561;25171321;25565209;2559024;25753332;25994790;26421717;26976564;27099988;27669901;2838329;2844759;28645727;29526322;2953725;29594857;30379171;31844290;33717175;34127021;35051231;35494241;35705078;5961668;6328127;7399049;7702581;7929371;8021246;8798450;8918259;9346285;9856482",
        "class_list": "",
        "function": "Mediates the electrogenic exchange of Ca(2+) against Na(+) ions across the cell membrane, and thereby contributes to the regulation of cytoplasmic Ca(2+) levels and Ca(2+)-dependent cellular processes. Contributes to cellular Ca(2+) homeostasis in excitable cells, both in muscle and in brain. In a first phase, voltage-gated channels mediate the rapid increase of cytoplasmic Ca(2+) levels due to release of Ca(2+) stores from the endoplasmic reticulum. SLC8A3 mediates the export of Ca(2+) from the cell during the next phase, so that cytoplasmic Ca(2+) levels rapidly return to baseline. Contributes to Ca(2+) transport during excitation-contraction coupling in muscle. In neurons, contributes to the rapid decrease of cytoplasmic Ca(2+) levels back to baseline after neuronal activation, and thereby contributes to modulate synaptic plasticity, learning and memory (By similarity). Required for normal oligodendrocyte differentiation and for normal myelination (PubMed:21959935). Mediates Ca(2+) efflux from mitochondria and contributes to mitochondrial Ca(2+) ion homeostasis (By similarity)., [UniProtKB, PubMed, UniProtKB]; Sodium-calcium exchanger-3 regulates pain ''wind-up'': From human psychophysics to spinal mechanisms., [RefSeq, PubMed]; Structure-Dynamic Coupling Through Ca(2+)-Binding Regulatory Domains of Mammalian NCX Isoform/Splice Variants Review article, [RefSeq, PubMed]; The downregulation of NCXs is positively correlated with the prognosis of stage II-IV colon cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The gene promoter of the human isoform of this protein is controlled by cAMP and calcium., [RefSeq, PubMed]; These results...suggest that cells can use a dynamic Ca(2+) signaling toolkit in which the NCX3 sub-cellular localization changes in synchrony with the cell cycle, [RefSeq, PubMed]; This gene encodes a member of the sodium/calcium exchanger integral membrane protein family. Na+/Ca2+ exchange proteins are involved in maintaining Ca2+ homeostasis in a wide variety of cell types. The protein is regulated by intracellular calcium ions and is found in both the plasma membrane and intracellular organellar membranes, where exchange of Na+ for Ca2+ occurs in an electrogenic manner. Alternative splicing has been observed for this gene and multiple variants have been described. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
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        "reported_snv": 13,
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        "biomarker_type": "",
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        "secondary_ac_list": "Q5K3P6;Q5K3P7;Q8IUE9;Q8IUF0;Q8NFI7;Q96QG1;Q96QG2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0046872 metal ion binding;GO:0005432 calcium:sodium antiporter activity;GO:1905060 calcium:monoatomic cation antiporter activity involved in regulation of postsynaptic cytosolic calcium ion concentration",
        "go_cellular_component": "GO:0005741 mitochondrial outer membrane;GO:0005829 cytosol;GO:0005874 microtubule;GO:0005886 plasma membrane;GO:0014069 postsynaptic density",
        "go_biological_process": "GO:1902532 negative regulation of intracellular signal transduction;GO:0007611 learning or memory;GO:0007612 learning;GO:0007613 memory;GO:0050808 synapse organization",
        "synthesized_glycan_count": 0,
        "hit_score": 10.7,
        "record_id": "P57103-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100100010001.111.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P13385-1",
        "uniprot_id": [
            {
                "id": "TDGF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P13385",
                "type": "external"
            }
        ],
        "mass": 21169.0,
        "length": 188,
        "protein_name": "Protein Cripto",
        "gene_name": "CRIPTO",
        "organism": "Human",
        "refseq_name": "protein Cripto isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001167607",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001167607",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CRIPTO; CRIPTO-1; TDGF1",
        "gene_names_refseq": "CR-1; CRGF; CRIPTO; CR; TDGF1",
        "protein_names_uniprotkb": "Protein Cripto; CRGF; Cripto, EGF-CFC family member; Cripto-1 growth factor; Epidermal growth factor-like cripto protein CR1; Teratocarcinoma-derived growth factor 1",
        "protein_names_refseq": "cripto-1 growth factor; epidermal growth factor-like cripto protein CR1; protein Cripto isoform 2; protein Cripto; teratocarcinoma-derived growth factor 1",
        "tax_id": 9606,
        "disease": "neural tube defect (Disease Ontology:DOID:0080074); congenital heart disease (Disease Ontology:DOID:1682); colon cancer (Disease Ontology:DOID:219)",
        "pathway": " (hsa:6997);  (R-HSA-1181150);  (R-HSA-1433617);  (R-HSA-2892247)",
        "pathway_count": 4,
        "publication_count": 92,
        "publication_id_list": "10067895;10209961;10473623;10822381;10934479;11024047;11237011;11294908;11389842;11485994;11500501;11751684;11779503;11779505;11855863;11909953;12063393;12065233;12592392;12919325;14681828;14978253;15062104;15150278;15277698;15340161;15342941;15350224;15485907;15531507;15955829;16153702;16260601;16397896;16670092;16846370;16862074;16954206;16978057;17068183;1715580;17204602;17267691;17272273;17506876;17567999;17572666;18212089;18366076;18388306;18653770;1882841;18835250;18930707;19114992;19128516;19440552;19544431;19696931;19829295;20505756;20505821;20526341;20549704;20616345;20624125;20694664;20872845;21049019;21356369;21383881;21532621;22215994;22887036;24218367;25603319;27881714;2792079;34502188;34517344;34569498;34943832;35434129;7545930;7688835;8878477;9288972;9311995;9354794;9670020;9702198;9807024",
        "class_list": "",
        "function": "CRIPTO-1 Is Immunolocalized in the Syncytiotrophoblast of Ampullary Pregnancies. Publication Status: Online-Only, [RefSeq, PubMed]; Cripto-1 as a Key Factor in Tumor Progression, Epithelial to Mesenchymal Transition and Cancer Stem Cells. Review article Publication Status: Online-Only, [RefSeq, PubMed]; GPI-anchored cell membrane protein involved in Nodal signaling. Cell-associated CRIPTO acts as a Nodal coreceptor in cis. Shedding of CRIPTO by TMEM8A modulates Nodal signaling by allowing soluble CRIPTO to act as a Nodal coreceptor on other cells (PubMed:27881714). Could play a role in the determination of the epiblastic cells that subsequently give rise to the mesoderm (PubMed:11909953)., [UniProtKB, PubMed, PubMed]; Liver-specific over-expression of Cripto-1 in transgenic mice promotes hepatocyte proliferation and deregulated expression of hepatocarcinogenesis-related genes and signaling pathways., [RefSeq, PubMed]; MiR-3929 Inhibits Proliferation and Promotes Apoptosis by Downregulating Cripto-1 Expression in Cervical Cancer Cells., [RefSeq, PubMed]; Oncofetal Protein CRIPTO Is Involved in Wound Healing and Fibrogenesis in the Regenerating Liver and Is Associated with the Initial Stages of Cardiac Fibrosis. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes an epidermal growth factor-related protein that contains a cripto, FRL-1, and cryptic domain. The encoded protein is an extracellular, membrane-bound signaling protein that plays an essential role in embryonic development and tumor growth. Mutations in this gene are associated with forebrain defects. Pseudogenes of this gene are found on chromosomes 2, 3, 6, 8, 19 and X. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 1,
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        "secondary_ac_list": "Q8TCC1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0008083 growth factor activity;GO:0038100 nodal binding;GO:0070697 activin receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0045121 membrane raft",
        "go_biological_process": "GO:0009792 embryo development ending in birth or egg hatching;GO:0007507 heart development;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0030335 positive regulation of cell migration",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "P13385-1",
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        "filter_code": "0000000.1100111.100000.000000000001000000.0000010010000.011.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N699-1",
        "uniprot_id": [
            {
                "id": "MYCT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N699",
                "type": "external"
            }
        ],
        "mass": 26593.0,
        "length": 235,
        "protein_name": "Myc target protein 1",
        "gene_name": "MYCT1",
        "organism": "Human",
        "refseq_name": "myc target protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_079383",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_079383",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYCT1; MTLC; MTMC1",
        "gene_names_refseq": "MTLC; MYCT1",
        "protein_names_uniprotkb": "Myc target protein 1; Myc target in myeloid cells protein 1",
        "protein_names_refseq": "myc target in myeloid cells 1; myc target in myeloid cells protein 1; myc target protein 1 isoform 1; myc target protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80177)",
        "pathway_count": 1,
        "publication_count": 15,
        "publication_id_list": "11237011;12673574;14562369;20166139;21799513;21998677;22672838;28832583;29557506;31154438;33658356;34604957;37499454;38112991;38172714",
        "class_list": "",
        "function": "Dual role of endothelial Myct1 in tumor angiogenesis and tumor immunity., [RefSeq, PubMed]; Hypermethylation contributed to the transcriptional down-regulation of MYCT1 and could inhibit cancer cell differentiation in laryngeal squamous cell cancer. Publication Status: Online-Only, [RefSeq, PubMed]; MTLC was down-regulated in the majority of gastric cancer tissues and could promote apoptosis of GC cell lines, which suggests that MTLC may play an important role in the carcinogenesis of gastric carcinoma., [RefSeq, PubMed]; MYCT-1 Gene Expression in Patients with Gastric Cancer: an Ex Vivo Study., [RefSeq, PubMed]; MYCT1 in cancer development: Gene structure, regulation, and biological implications for diagnosis and treatment. Review article, [RefSeq, PubMed]; MYCT1 inhibits hematopoiesis in diffuse large B-cell lymphoma by suppressing RUNX1 transcription. Publication Status: Online-Only, [RefSeq, PubMed]; MYCT1-TV, a novel MYCT1 transcript, is regulated by c-Myc and down-regulation of MYCT1-TV/MYCT1 could contribute to LSCC development and function, [RefSeq, PubMed]; May regulate certain MYC target genes, MYC seems to be a direct upstream transcriptional activator. Does not seem to significantly affect growth cell capacity. Overexpression seems to mediate many of the known phenotypic features associated with MYC, including promotion of apoptosis, alteration of morphology, enhancement of anchorage-independent growth, tumorigenic conversion, promotion of genomic instability, and inhibition of hematopoietic differentiation (By similarity)., [UniProtKB]; Nitrosative stress induces downregulation of ribosomal protein genes via MYCT1 in vascular smooth muscle cells. Erratum:[Eur Rev Med Pharmacol Sci. 2022 Oct;26(19):6893. doi: 10.26355/eurrev_202210_29866. PMID: 36263566], [RefSeq, PubMed]; Results suggest MYCT1 transcription can be activated downstream of RUNX1-ETO as well as MYC, contributing to key aspects of the leukaemic phenotypes these oncoproteins promote, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q8N396;Q8TBE8;Q9H763",
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        "go_cellular_component": "GO:0005654 nucleoplasm",
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    },
    {
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            {
                "id": "MRM2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UI43",
                "type": "external"
            }
        ],
        "mass": 27424.0,
        "length": 246,
        "protein_name": "rRNA methyltransferase 2, mitochondrial",
        "gene_name": "MRM2",
        "organism": "Human",
        "refseq_name": "rRNA methyltransferase 2, mitochondrial",
        "refseq_ac": [
            {
                "id": "NP_037525",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_037525",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MRM2; FJH1; FTSJ2",
        "gene_names_refseq": "FJH1; FTSJ2; HEL97; MRM2; MTDPS17; RRMJ2",
        "protein_names_uniprotkb": "rRNA methyltransferase 2, mitochondrial; 16S rRNA (uridine(1369)-2'-O)-methyltransferase; 16S rRNA [Um1369] 2'-O-methyltransferase; 2.1.1.-; Protein ftsJ homolog 2",
        "protein_names_refseq": "16S rRNA (uridine(1369)-2'-O)-methyltransferase; 16S rRNA [Um1369] 2'-O-methyltransferase; FtsJ RNA methyltransferase homolog 2; FtsJ homolog 2; MRM2 RNA methyltransferase homolog; cell division protein FtsJ; epididymis luminal protein 97; protein ftsJ homolog 2; putative ribosomal RNA methyltransferase 2; rRNA (uridine-2'-O-)-methyltransferase; rRNA methyltransferase 2, mitochondrial",
        "tax_id": 9606,
        "disease": "mitochondrial DNA depletion syndrome 17 (Disease Ontology:DOID:0070448); MELAS syndrome (Disease Ontology:DOID:3687)",
        "pathway": " (hsa:29960);  (R-HSA-6793080)",
        "pathway_count": 2,
        "publication_count": 53,
        "publication_id_list": "11237011;11809803;11827451;12496758;15110318;19356719;19417006;20877624;21531335;22341444;22645359;22949673;23022348;23303773;23804760;24036117;25009282;25074936;26464487;26992070;27600516;27667664;27920218;27974379;28063628;28082677;28228285;28832583;28904123;28973171;29242379;29493099;29632046;31844290;31848261;31998317;32157095;32161166;32357974;32488085;32502341;32938616;33691108;33912179;33968037;34087483;34171305;34357683;34561969;35177605;36002240;36215666;37938771",
        "class_list": "",
        "function": "FTSJ2 is a nucleolar RNA methyltransferase involved in eukaryotic RNA processing and modification., [RefSeq, PubMed]; MRM2 variants in families with complex dystonic syndromes: evidence for phenotypic heterogeneity., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; S-adenosyl-L-methionine-dependent 2'-O-ribose methyltransferase that catalyzes the formation of 2'-O-methyluridine at position 1369 (Um1369) in the 16S mitochondrial large subunit ribosomal RNA (mtLSU rRNA), a universally conserved modification in the peptidyl transferase domain of the mtLSU rRNA (PubMed:25009282, PubMed:25074936, PubMed:35177605). This activity may require prior 2'-O-methylguanosine modification at position 1370 (Gm1370) by MRM3 (PubMed:35177605). Essential for late-stage assembly of mtLSU required for efficient translation of mitochondrial DNA encoded proteins; methyltransferase activity is not required for this function (PubMed:35177605). Essential for mitochondrial respiratory function (PubMed:35177605)., [UniProtKB, PubMed, PubMed, PubMed]; The protein encoded by this gene is a member of the S-adenosylmethionine-binding protein family. It is a nucleolar protein and it may be involved in the processing and modification of rRNA. This gene has been suggested to be involved in cell cycle control and DNA repair. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q24JR8",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008650 rRNA (uridine-2'-O-)-methyltransferase activity;GO:0008168 methyltransferase activity",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0031167 rRNA methylation;GO:0006364 rRNA processing;GO:1902775 mitochondrial large ribosomal subunit assembly;GO:0001510 RNA methylation;GO:0000451 rRNA 2'-O-methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q9UI43-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95168-1",
        "uniprot_id": [
            {
                "id": "NDUB4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95168",
                "type": "external"
            }
        ],
        "mass": 15209.0,
        "length": 129,
        "protein_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4",
        "gene_name": "NDUFB4",
        "organism": "Human",
        "refseq_name": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001161803",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161803",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NDUFB4",
        "gene_names_refseq": "B15; CI-B15; NDUFB4",
        "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4; CI-B15; Complex I-B15; NADH-ubiquinone oxidoreductase B15 subunit",
        "protein_names_refseq": "NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 4, 15kDa; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4 isoform 2; NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 4; NADH-ubiquinone oxidoreductase B15 subunit; complex I B15 subunit; complex I-B15",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4710);  (R-HSA-611105);  (R-HSA-6799198)",
        "pathway_count": 3,
        "publication_count": 115,
        "publication_id_list": "10327278;11220739;11237011;11695836;12231006;12611891;12837546;1327877;14741580;15250827;16230336;17033964;17936786;186667;18991276;19752196;20406883;20552642;20858599;21924235;23150584;23186163;23270816;23481700;23553477;23564345;23747254;239860;24191001;24714562;24715725;25418920;25564869;25576301;25645385;25678554;26154972;26728094;26992070;27499296;27600516;27626371;27846572;27862975;27920218;28063628;28218747;28228285;28832583;28834231;28855257;28904123;29242379;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30429286;30779550;31154438;31222486;31530632;31666358;31844290;31848261;31866046;31937595;31998317;32157095;32161166;32265295;32320651;32350084;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33633747;33691108;33717175;33879611;33882309;33912179;33936100;33968037;34087483;34171305;34211107;34509645;34561969;35051231;35333655;35580925;35614220;36010968;36215666;36241641;36284347;38199007;38211818;39894887;4288886;9571201;9878551",
        "class_list": "",
        "function": "Accessory subunit NDUFB4 participates in mitochondrial complex I supercomplex formation., [RefSeq, PubMed]; Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; This gene encodes a non-catalytic subunit of the multisubunit NADH:ubiquinone oxidoreductase, the first enzyme complex in the mitochondrial electron transport chain (complex I). Mammalian complex I is composed of 45 different subunits and transfers electrons from NADH to ubiquinone. [provided by RefSeq, Dec 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RUY3;B9EJC7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I",
        "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration;GO:0022904 respiratory electron transport chain",
        "synthesized_glycan_count": 0,
        "hit_score": 11.8,
        "record_id": "O95168-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P29120-1",
        "uniprot_id": [
            {
                "id": "NEC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P29120",
                "type": "external"
            }
        ],
        "mass": 84152.0,
        "length": 753,
        "protein_name": "Neuroendocrine convertase 1",
        "gene_name": "PCSK1",
        "organism": "Human",
        "refseq_name": "neuroendocrine convertase 1 isoform 1 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_000430",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000430",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PCSK1; NEC1",
        "gene_names_refseq": "BMIQ12; NEC1; PC1/3; PC1; PC3; PCSK1; SPC3",
        "protein_names_uniprotkb": "Neuroendocrine convertase 1; 3.4.21.93; NEC 1; PC1; Prohormone convertase 1; Proprotein convertase 1",
        "protein_names_refseq": "neuroendocrine convertase 1 isoform 1 preproprotein; neuroendocrine convertase 1; prohormone convertase 1; prohormone convertase 3; proprotein convertase 1/3",
        "tax_id": 9606,
        "disease": "proprotein convertase 1/3 deficiency (Disease Ontology:DOID:0111698); hypothyroidism (Disease Ontology:DOID:1459); islet cell tumor (Disease Ontology:DOID:1799); endocrine system disease (Disease Ontology:DOID:28); hyperglycemia (Disease Ontology:DOID:4195); hyperthyroidism (Disease Ontology:DOID:7998); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:5122);  (R-HSA-209952);  (R-HSA-264876);  (R-HSA-381771);  (R-HSA-400511);  (R-HSA-422085)",
        "pathway_count": 6,
        "publication_count": 106,
        "publication_id_list": "10.1038/emboj.2013.79;10366038;10391209;10521251;10604470;11089560;11237011;11462236;11493706;11564718;11600536;11707400;11756331;11904301;11978683;12050285;12354137;12414809;12540594;12553549;12651102;12810581;14463577;14599721;14617756;14704853;14719035;14719797;1499644;15126524;15126574;15142980;15256494;1528899;15331542;1547893;15584901;15604212;15619630;15878854;1605851;16158220;16158222;16219666;16407158;16714477;16728727;16984975;17065399;17289852;17595246;17595255;17681422;18202141;18396350;18443287;18519800;18593849;18604207;19001044;19280057;19327128;19628676;20308425;21091435;21145486;21308844;21713314;23234360;23584533;25091901;2669954;2822027;2890159;29393594;29557506;30078552;30828317;31154438;31184304;32161166;32723473;32928873;33485965;33592498;35051231;36822744;36864747;37761915;37877373;37938771;38009939;3841689;3896518;3900195;7626024;7797529;7883856;8100523;8428636;8666140;8798518;8916141;9166668;9207799;9631292",
        "class_list": "",
        "function": "Association of PCSK1 and PPARG1 Allelic Variants with Obesity and Metabolic Syndrome in Mexican Adults. Publication Status: Online-Only, [RefSeq, PubMed]; Contribution of heterozygous PCSK1 variants to obesity and implications for precision medicine: a case-control study., [RefSeq, PubMed]; Differential sex-association between PCSK1 polymorphisms and obesity risk in Portuguese children., [RefSeq, PubMed]; Functional characterization of all missense variants in LEPR, PCSK1, and POMC genes arising from single-nucleotide variants., [RefSeq, PubMed]; Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, oxytocin, vasopressin, enkephalin, dynorphin, somatostatin, insulin and AGRP., [UniProtKB, UniProtKB]; The N221D variant in PCSK1 is highly prevalent in childhood obesity and can influence the metabolic profile. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the subtilisin-like proprotein convertase family, which includes proteases that process protein and peptide precursors trafficking through regulated or constitutive branches of the secretory pathway. The encoded protein undergoes an initial autocatalytic processing event in the ER to generate a heterodimer which exits the ER and sorts to subcellular compartments where a second autocatalytic even takes place and the catalytic activity is acquired. The protease is packaged into and activated in dense core secretory granules and expressed in the neuroendocrine system and brain. This gene encodes one of the seven basic amino acid-specific members which cleave their substrates at single or paired basic residues. It functions in the proteolytic activation of polypeptide hormones and neuropeptides precursors. Mutations in this gene have been associated with susceptibility to obesity and proprotein convertase 1/3 deficiency. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene [provided by RefSeq, Jan 2014]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 8,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z8T7;E9PHA1;P78478;Q92532",
        "ec_number_list": [
            {
                "id": "3.4.21.93",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.93",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0042802 identical protein binding;GO:0008236 serine-type peptidase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0034774 secretory granule lumen;GO:0043005 neuron projection;GO:0030133 transport vesicle",
        "go_biological_process": "GO:0006508 proteolysis;GO:0007267 cell-cell signaling;GO:0016486 peptide hormone processing;GO:0043043 peptide biosynthetic process;GO:0030070 insulin processing",
        "synthesized_glycan_count": 0,
        "hit_score": 11.4,
        "record_id": "P29120-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UKX2-1",
        "uniprot_id": [
            {
                "id": "MYH2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UKX2",
                "type": "external"
            }
        ],
        "mass": 223044.0,
        "length": 1941,
        "protein_name": "Myosin-2",
        "gene_name": "MYH2",
        "organism": "Human",
        "refseq_name": "myosin-2",
        "refseq_ac": [
            {
                "id": "NP_001093582",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001093582",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYH2; MYHSA2",
        "gene_names_refseq": "CMYO6; CMYP6; IBM3; MYH2A; MYH2; MYHSA2; MYHas8; MyHC-2A; MyHC-IIa",
        "protein_names_uniprotkb": "Myosin-2; MyHC-2a; MyHC-IIa; Myosin heavy chain 2a; Myosin heavy chain 2; Myosin heavy chain IIa; Myosin heavy chain, skeletal muscle, adult 2",
        "protein_names_refseq": "fast 2a myosin heavy chain; inclusion body myopathy 3, autosomal dominant; myosin heavy chain 2a; myosin heavy chain IIa; myosin heavy chain, skeletal muscle, adult 2; myosin, heavy chain 2, skeletal muscle, adult; myosin, heavy polypeptide 2, skeletal muscle, adult; myosin-2; type IIA myosin heavy chain",
        "tax_id": 9606,
        "disease": "distal arthrogryposis (Disease Ontology:DOID:0050646); cardiomyopathy (Disease Ontology:DOID:0050700); familial hypertrophic cardiomyopathy (Disease Ontology:DOID:0080326); congenital myopathy 6 (Disease Ontology:DOID:0080719); dilated cardiomyopathy 1S (Disease Ontology:DOID:0110454); autosomal dominant hyaline body myopathy (Disease Ontology:DOID:0111269); distal arthrogryposis type 1 (Disease Ontology:DOID:0111596); distal arthrogryposis type 2B3 (Disease Ontology:DOID:0111602); distal arthrogryposis type 2A (Disease Ontology:DOID:0111605); distal myopathy (Disease Ontology:DOID:11720); dilated cardiomyopathy (Disease Ontology:DOID:12930); myotonia congenita (Disease Ontology:DOID:2106); inclusion body myositis (Disease Ontology:DOID:3429); restrictive cardiomyopathy (Disease Ontology:DOID:397); myopathy (Disease Ontology:DOID:423)",
        "pathway": " (hsa:4620);  (R-HSA-2029482);  (R-HSA-9664422)",
        "pathway_count": 3,
        "publication_count": 77,
        "publication_id_list": "10219243;10388558;10496324;10559936;10724160;10781580;10878810;10995437;11114175;11157975;11231582;11237011;11276226;11278486;11329366;11340081;11553796;11747816;11804587;11829459;11854399;12055636;12105426;12189515;12213210;12235133;12428245;12743368;1314888;14676198;15040784;15452139;15657136;15741996;16262445;16546099;16641196;16702231;16880808;17081983;17188549;17202194;17308335;17823310;18070890;18391171;19741094;19955216;20068231;21037092;21419341;23675550;2474607;27397612;27862975;27893789;29557506;31154438;32161166;32938616;35051231;35580925;36010968;37154181;37218133;37871676;7545970;7751403;7848918;8809042;8986718;9600938;9705280;9799231;9843499;9883880;9885284",
        "class_list": "",
        "function": "Analysis of normal variation indicates that there is strong selective pressure against mutations in MYH2; On the basis of these results, we suggest that MyHC genes should be regarded as candidate genes in hereditary myopathies of unknown etiology., [RefSeq, PubMed]; MYH2-related Myopathy: Expanding the Clinical Spectrum of Chronic Progressive External Ophthalmoplegia (CPEO)., [RefSeq, PubMed]; Myosin heavy chain 2 (MYH2) expression in hypertrophic chondrocytes of soft callus provokes endochondral bone formation in fracture., [RefSeq, PubMed]; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction., [UniProtKB, UniProtKB]; Myosins are actin-based motor proteins that function in the generation of mechanical force in eukaryotic cells. Muscle myosins are heterohexamers composed of 2 myosin heavy chains and 2 pairs of nonidentical myosin light chains. This gene encodes a member of the class II or conventional myosin heavy chains, and functions in skeletal muscle contraction. This gene is found in a cluster of myosin heavy chain genes on chromosome 17. A mutation in this gene results in inclusion body myopathy-3. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Sep 2009]., [RefSeq]; Nonmuscle myosin 2 filaments are processive in cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 36,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 36,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 15,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVL4;Q14322;Q16229;Q567P6;Q86T56",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005516 calmodulin binding;GO:0005524 ATP binding;GO:0051015 actin filament binding;GO:0000146 microfilament motor activity;GO:0003779 actin binding",
        "go_cellular_component": "GO:0005859 muscle myosin complex;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005911 cell-cell junction;GO:0030017 sarcomere",
        "go_biological_process": "GO:0006936 muscle contraction;GO:0030049 muscle filament sliding",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q9UKX2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y3D2-1",
        "uniprot_id": [
            {
                "id": "MSRB2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y3D2",
                "type": "external"
            }
        ],
        "mass": 19536.0,
        "length": 182,
        "protein_name": "Methionine-R-sulfoxide reductase B2, mitochondrial",
        "gene_name": "MSRB2",
        "organism": "Human",
        "refseq_name": "methionine-R-sulfoxide reductase B2, mitochondrial precursor",
        "refseq_ac": [
            {
                "id": "NP_036360",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036360",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MSRB2; CBS-1; CGI-131; MSRB",
        "gene_names_refseq": "CBS-1; CBS1; CGI-131; MSRB2; MSRB; PILB",
        "protein_names_uniprotkb": "Methionine-R-sulfoxide reductase B2, mitochondrial; 1.8.4.12; 1.8.4.14; MsrB2",
        "protein_names_refseq": "methionine-R-sulfoxide reductase B2, mitochondrial precursor; methionine-R-sulfoxide reductase B2, mitochondrial; pilin-like transcription factor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22921);  (R-HSA-5676934)",
        "pathway_count": 2,
        "publication_count": 25,
        "publication_id_list": "10375640;10452521;10567350;11237011;12220640;14759519;15914630;18424444;25078755;25576301;28218747;29437277;29731959;30315122;31154438;31282614;31844290;31848261;32157095;32387766;33298915;34509645;3624258;38638027;7592526",
        "class_list": "",
        "function": "CBS1, a methionine sulfoxide reductase of type B, is most abundant in muscle tissues, especially in the heart and thereby shows an expression pattern different to the human methionine sulfoxide reductase A, [RefSeq, PubMed]; MSRB is down-regulated during cell aging., [RefSeq, PubMed]; MSRB2 Ameliorates H2O2-induced Chondrocyte Oxidative Stress and Suppresses Apoptosis in Osteoarthritis., [RefSeq, PubMed]; Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Upon oxidative stress, may play a role in the preservation of mitochondrial integrity by decreasing the intracellular reactive oxygen species build-up through its scavenging role, hence contributing to cell survival and protein maintenance., [UniProtKB, PubMed]; Release of the enzyme MsrB2 from damaged mitochondria, initiating autophagosome formation, represents a novel regulatory mechanism for oxidative stress-induced mitophagy., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q17R44;Q4G1C7;Q9Y5W6",
        "ec_number_list": [
            {
                "id": "1.8.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.12",
                "type": "external"
            },
            {
                "id": "1.8.4.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.4.14",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0033743 peptide-methionine (R)-S-oxide reductase activity;GO:0033745 L-methionine-(R)-S-oxide reductase activity;GO:0003779 actin binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005829 cytosol",
        "go_biological_process": "GO:0006979 response to oxidative stress;GO:0030041 actin filament polymerization;GO:0030091 protein repair",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q9Y3D2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HD47-1",
        "uniprot_id": [
            {
                "id": "MOG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HD47",
                "type": "external"
            }
        ],
        "mass": 20448.0,
        "length": 186,
        "protein_name": "Ran guanine nucleotide release factor",
        "gene_name": "RANGRF",
        "organism": "Human",
        "refseq_name": "ran guanine nucleotide release factor isoform B",
        "refseq_ac": [
            {
                "id": "NP_001171272",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171272",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RANGRF; HSPC165; HSPC236; MDS5; MOG1; RANGNRF",
        "gene_names_refseq": "HSPC165; HSPC236; MOG1; RANGNRF; RANGRF",
        "protein_names_uniprotkb": "Ran guanine nucleotide release factor; Ran-binding protein MOG1; RanGNRF",
        "protein_names_refseq": "MOG1 homolog; ran guanine nucleotide release factor isoform B; ran-binding protein MOG1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:29098);  (R-HSA-5576892)",
        "pathway_count": 2,
        "publication_count": 44,
        "publication_id_list": "11290418;1309946;14500339;15000524;18184654;19406745;21127204;21447824;21566136;21621375;21817159;22054663;22514276;23420830;23481700;23804213;24142675;24366607;28832583;28904123;29040603;29242379;29393594;29508533;29557506;30282806;30429286;31154438;31217245;31530632;31844290;31998317;32157095;32265295;32938616;33298915;33592498;33912179;33968037;34932366;35318648;35580925;36284347;8107964",
        "class_list": "",
        "function": "In cardiomyocytes, MOG1 is mostly localized in the cell membrane and co-localized with Nav1.5, indicating that MOG1 is a critical regulator of sodium channel function in the heart, [RefSeq, PubMed]; May regulate the intracellular trafficking of RAN (PubMed:11290418). Promotes guanine nucleotide release from RAN and inhibits binding of new GTP by preventing the binding of the RAN guanine nucleotide exchange factor RCC1 (PubMed:29040603). Regulates the levels of GTP-bound RAN in the nucleus, and thereby plays a role in the regulation of RAN-dependent mitotic spindle dynamics (PubMed:29040603). Enhances the expression of SCN5A at the cell membrane in cardiomyocytes (PubMed:18184654, PubMed:21621375, PubMed:23420830)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Results suggest that dominant-negative mutations in MOG1 can impair the trafficking of Na(v)1.5 to the membrane, leading to I(Na) reduction and clinical manifestation of Brugada syndrome., [RefSeq, PubMed]; The MOG1 domain required for the interaction with Nav1.5 to the region spanning amino acids 146-174, and a refined deletion analysis further narrowed this domain to amino acids146-155., [RefSeq, PubMed]; This gene encodes a protein that has been shown to function as a guanine nucleotide release factor in mouse and to regulate the expression and function of the Nav1.5 cardiac sodium channel in human. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_mutagensis": 4,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "D3DTR6;Q68DI3;Q9BR68;Q9HD48;Q9NRU9;Q9P001;Q9P0P2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017080 sodium channel regulator activity;GO:0044325 transmembrane transporter binding;GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding;GO:0099103 channel activator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005791 rough endoplasmic reticulum;GO:0005829 cytosol",
        "go_biological_process": "GO:1900825 regulation of membrane depolarization during cardiac muscle cell action potential;GO:0090307 mitotic spindle assembly;GO:2000010 positive regulation of protein localization to cell surface;GO:0060047 heart contraction;GO:0006888 endoplasmic reticulum to Golgi vesicle-mediated transport",
        "synthesized_glycan_count": 0,
        "hit_score": 4.5,
        "record_id": "Q9HD47-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NR99-1",
        "uniprot_id": [
            {
                "id": "MXRA5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NR99",
                "type": "external"
            }
        ],
        "mass": 312150.0,
        "length": 2828,
        "protein_name": "Matrix-remodeling-associated protein 5",
        "gene_name": "MXRA5",
        "organism": "Human",
        "refseq_name": "matrix-remodeling-associated protein 5 precursor",
        "refseq_ac": [
            {
                "id": "NP_056234",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056234",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MXRA5",
        "gene_names_refseq": "MXRA5",
        "protein_names_uniprotkb": "Matrix-remodeling-associated protein 5; Adhesion protein with leucine-rich repeats and immunoglobulin domains related to perlecan; Adlican",
        "protein_names_refseq": "adhesion protein with leucine-rich repeats and Immunoglobulin domains related to perlecan; adlican; matrix-remodeling-associated protein 5 precursor; matrix-remodelling associated 5",
        "tax_id": 9606,
        "disease": "lung cancer (Disease Ontology:DOID:1324)",
        "pathway": " (hsa:25878)",
        "pathway_count": 1,
        "publication_count": 52,
        "publication_id_list": "10.1038/emboj.2013.79;15609104;19615748;22696596;22898188;23090970;23092983;23481700;23584533;24190977;24715725;25326458;25576301;26406953;26566883;26740625;27599751;27726376;27846572;28904123;29557506;29632711;29741879;29786170;30192525;30429286;30459171;31154438;31217245;31844290;31848261;32157095;32337544;32392178;32938616;33141586;33592498;33633747;34087483;34171305;34211107;34211612;35051231;35580925;36213313;36284347;37074911;37217939;37730838;38253038;39148085;39462449",
        "class_list": "",
        "function": "HIF-1alpha Activates Hypoxia-Induced MXRA5 Expression in the Progression of Ovarian Cancer., [RefSeq, PubMed]; Identification and functional activity of matrix-remodeling associated 5 (MXRA5) in benign hyperplastic prostate., [RefSeq, PubMed]; Identification of HTRA1, DPT and MXRA5 as potential biomarkers associated with osteoarthritis progression and immune infiltration. Publication Status: Online-Only, [RefSeq, PubMed]; In kidney, has anti-inflammatory and anti-fibrotic properties by limiting the induction of chemokines, fibronectin and collagen expression in response to TGB1 and pro-inflammatory stimuli., [UniProtKB, PubMed]; MXRA5 Is a Novel Immune-Related Biomarker That Predicts Poor Prognosis in Glioma. Publication Status: Online-Only, [RefSeq, PubMed]; Public RNA-seq data-based identification and functional analyses reveal that MXRA5 retains proliferative and migratory abilities of dental pulp stem cells. Publication Status: Online-Only, [RefSeq, PubMed]; Screened one most frequently mutated novel gene, matrix-remodeling associated 5 (MXRA5), in an additional larger Chinese sample set of 52 patients with NSCLC and confirmed its high somatic mutation frequency, [RefSeq, PubMed]; These results indicated the potential value of MXRA5 as a novel therapeutic target for the treatment of non-small cell lung cancer., [RefSeq, PubMed]; This gene encodes one of the matrix-remodelling associated proteins. This protein contains 7 leucine-rich repeats and 12 immunoglobulin-like C2-type domains related to perlecan. This gene has a pseudogene on chromosome Y. [provided by RefSeq, Mar 2010]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 9,
        "reported_o_glycosites_with_glycan": 31,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 9,
        "total_reported_o_glycosites": 32,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 9,
        "total_o_glycosites": 32,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 139,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 59,
        "disease_count": 1,
        "glyco_site_count": 46,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6P1M7;Q9Y3Y8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005201 extracellular matrix structural constituent",
        "go_cellular_component": "GO:0031012 extracellular matrix;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0071559 response to transforming growth factor beta",
        "synthesized_glycan_count": 0,
        "hit_score": 15.3,
        "record_id": "Q9NR99-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.001000.000000000001000000.1100000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z5D8-1",
        "uniprot_id": [
            {
                "id": "NANGN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z5D8",
                "type": "external"
            }
        ],
        "mass": 22750.0,
        "length": 188,
        "protein_name": "NANOG neighbor homeobox",
        "gene_name": "NANOGNB",
        "organism": "Human",
        "refseq_name": "NANOG neighbor homeobox",
        "refseq_ac": [
            {
                "id": "NP_001138937",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138937",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NANOGNB",
        "gene_names_refseq": "NANOGNB",
        "protein_names_uniprotkb": "NANOG neighbor homeobox; Homeobox protein C14",
        "protein_names_refseq": "NANOG neighbor homeobox; homeobox C14; homeobox protein C14",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:360030)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "11237011;32502341",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q7Z5D8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NDL7-1",
        "uniprot_id": [
            {
                "id": "MT21E_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NDL7",
                "type": "external"
            }
        ],
        "mass": 24458.0,
        "length": 214,
        "protein_name": "Methyltransferase-like protein 21E",
        "gene_name": "METTL21EP",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "METTL21EP; METTL21CP1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Methyltransferase-like protein 21E; 2.1.1.-",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "Protein-lysine methyltransferase., [UniProtKB]",
        "predicted_glycosites": 0,
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        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AA34QW07",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008276 protein methyltransferase activity",
        "go_cellular_component": "GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0032259 methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A6NDL7-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96QE2-1",
        "uniprot_id": [
            {
                "id": "MYCT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96QE2",
                "type": "external"
            }
        ],
        "mass": 70371.0,
        "length": 648,
        "protein_name": "Proton myo-inositol cotransporter",
        "gene_name": "SLC2A13",
        "organism": "Human",
        "refseq_name": "proton myo-inositol cotransporter",
        "refseq_ac": [
            {
                "id": "NP_443117",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_443117",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC2A13",
        "gene_names_refseq": "HMIT; SLC2A13",
        "protein_names_uniprotkb": "Proton myo-inositol cotransporter; H(+)-myo-inositol cotransporter; H(+)-myo-inositol symporter; Hmit; Solute carrier family 2 member 13",
        "protein_names_refseq": "H(+)-myo-inositol symporter; h(+)-myo-inositol cotransporter; proton (H+) myo-inositol symporter; proton myo-inositol cotransporter; solute carrier family 2 (facilitated glucose transporter), member 13",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:114134);  (R-HSA-429593)",
        "pathway_count": 2,
        "publication_count": 49,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11500374;12039040;17081983;18767875;19032932;19413330;19415658;19473719;19607714;20068231;21679696;23186163;24190977;24275569;24715725;25576301;26154972;26811146;27600516;27846572;27920218;29317506;29393594;29557506;30429286;31548259;31689868;31844290;31918632;32157095;32350084;32387766;32488085;32938616;32983136;33592498;34357683;34561969;35051231;35318648;35580925;36215666;36241641;37938771;7537337;7789985;8626564",
        "class_list": "glycogene",
        "function": "Genetic alterations of TSPAN14, SLC2A13 and PHF20 could play a role in non-small-cell lung cancer promotion, [RefSeq, PubMed]; H(+)-myo-inositol cotransporter (PubMed:11500374). Can also transport related stereoisomers (PubMed:11500374)., [UniProtKB, PubMed]; HMIT is primarily a neuronal transporter widely expressed in the rat and human brain, with particularly high levels in the hippocampus and cortex, as shown by immunohistochemistry. Publication Status: Online-Only, [RefSeq, PubMed]; Our study revealed that both BDKRB2 and TENM2 genetic polymorphisms were interrogated in relation to anti-tuberculosis drug induced liver injury (ATDILI) susceptibility and some laboratory indicators in the Western Chinese Han population, shedding a new light on exploring novel biomarkers and targets for ATDILI., [RefSeq, PubMed]; The Solute Carrier Family 2 Genes Are Potential Prognostic Biomarkers in Acute Myeloid Leukemia., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 740,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q17S07",
        "ec_number_list": [],
        "go_molecular_function": "GO:0002020 protease binding;GO:0051117 ATPase binding;GO:0005366 myo-inositol:proton symporter activity;GO:0005365 myo-inositol transmembrane transporter activity;GO:0022857 transmembrane transporter activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030426 growth cone",
        "go_biological_process": "GO:0055085 transmembrane transport;GO:1902004 positive regulation of amyloid-beta formation;GO:0015798 myo-inositol transport;GO:0150104 transport across blood-brain barrier",
        "synthesized_glycan_count": 0,
        "hit_score": 5.4,
        "record_id": "Q96QE2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010001.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BSU3-1",
        "uniprot_id": [
            {
                "id": "NAA11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BSU3",
                "type": "external"
            }
        ],
        "mass": 25979.0,
        "length": 229,
        "protein_name": "N-alpha-acetyltransferase 11",
        "gene_name": "NAA11",
        "organism": "Human",
        "refseq_name": "N-alpha-acetyltransferase 11",
        "refseq_ac": [
            {
                "id": "NP_116082",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_116082",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAA11; ARD1B; ARD2",
        "gene_names_refseq": "ARD1B; ARD2; NAA11; hARD2",
        "protein_names_uniprotkb": "N-alpha-acetyltransferase 11; 2.3.1.255; N-terminal acetyltransferase complex ARD1 subunit homolog B; NatA catalytic subunit Naa11; hARD2",
        "protein_names_refseq": "=N-terminal acetyltransferase complex ARD1 subunit homolog B; ARD1 homolog B; N-alpha-acetyltransferase 11; N-terminal acetyltransferase complex ARD1 subunit homolog B; human arrest defective 2; natA catalytic subunit Naa11",
        "tax_id": 9606,
        "disease": "Ogden syndrome (Disease Ontology:DOID:0050781)",
        "pathway": " (hsa:84779)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;16638120;19660095;20419844;22048246;22292636;23186163;27600516;28904123;29557506;31217245;32157095;32488085;32502341;32938616;33141586;34211107;35051231;35580925",
        "class_list": "",
        "function": "ARD1 protein was observed at 61.0% (50/82), 54.7% (87/159), 37.9% (25/66), 36.8% (7/19) in IDC, fibroadenoma, hyperplasia, and inflammation, respectively., [RefSeq, PubMed]; Displays alpha (N-terminal) acetyltransferase activity. Proposed alternative catalytic subunit of the N-terminal acetyltransferase A (NatA) complex., [UniProtKB, PubMed]; HARD2, an N-alpha-acetyltransferase has 81 % sequence identity to hARD1. Its gene may originate from a eutherian-mammal-specific retrotransposition event. hARD2-NATH complexes may be responsible for protein N-alpha-acetylation in human cells. GeneRIF: hARD2 (MGC10646) is a novel human protein N-alpha acetyltransferase Publication Status: Online-Only, [RefSeq, PubMed]; LOH in genes around D4S2964, including ARD1B and SEPT11 may play an important role in hepatocellular carcinoma development and progression, [RefSeq, PubMed]; NAA11 expression is tissue-specific and is epigenetically regulated by DNA methylation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q66K19;Q6P479",
        "ec_number_list": [
            {
                "id": "2.3.1.255",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.255",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:1990189 protein N-terminal-serine acetyltransferase activity;GO:1990190 protein-N-terminal-glutamate acetyltransferase activity;GO:0008999 protein-N-terminal-alanine acetyltransferase activity",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031415 NatA complex",
        "go_biological_process": "GO:0006474 N-terminal protein amino acid acetylation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q9BSU3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15274-1",
        "uniprot_id": [
            {
                "id": "NADC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15274",
                "type": "external"
            }
        ],
        "mass": 30846.0,
        "length": 297,
        "protein_name": "Nicotinate-nucleotide pyrophosphorylase [carboxylating]",
        "gene_name": "QPRT",
        "organism": "Human",
        "refseq_name": "nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001305178",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305178",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "QPRT",
        "gene_names_refseq": "HEL-S-90n; QPRTase; QPRT",
        "protein_names_uniprotkb": "Nicotinate-nucleotide pyrophosphorylase [carboxylating]; 2.4.2.19; QAPRTase; QPRTase; Quinolinate phosphoribosyltransferase [decarboxylating]",
        "protein_names_refseq": "epididymis secretory sperm binding protein Li 90n; nicotinate-nucleotide pyrophosphorylase (carboxylating); nicotinate-nucleotide pyrophosphorylase [carboxylating] isoform 2",
        "tax_id": 9606,
        "disease": "Huntington's disease (Disease Ontology:DOID:12858); pellagra (Disease Ontology:DOID:8457)",
        "pathway": " (hsa:23475);  (R-HSA-196807)",
        "pathway_count": 2,
        "publication_count": 109,
        "publication_id_list": "10331643;10613898;11237011;11248244;11594753;11788603;11866528;11991719;12359228;12547821;12574164;12790796;13563527;14516279;14966140;15090606;15137942;15381699;15674325;16118205;1637327;16690024;17402747;17604275;17641676;17868694;17914902;18411268;19531469;20388704;21209280;2129526;21504897;21699903;21933152;21994945;22544926;22701565;22822066;23212377;23230272;23481700;24038671;24714562;24715725;24717514;24847004;25418920;25531177;25576301;25645385;26154972;26375851;26805589;26811146;26992070;27846572;27920218;28228285;28467828;28649982;28832583;28834231;28855257;28904123;29242379;29393594;29508533;29557506;30315122;30410026;30429286;30443311;30524438;31217245;31844290;32157095;32238439;32265295;32350084;32357974;32387766;32488085;32502341;32716908;32897882;32906142;32938616;33087354;33141586;33298915;33392160;33537174;33912179;34087483;34509645;35051231;35251023;36010968;36215666;36241641;37723185;4349867;8182091;8289818;8527488;8575745;8809081;9473669",
        "class_list": "",
        "function": "A comprehensive analysis of the role of QPRT in breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the catabolism of quinolinic acid (QA)., [UniProtKB, PubMed, PubMed, PubMed]; Our data suggest that QPRT may play an important role in the pathogenesis of autism spectrum disorders in Chr16p11.2 deletion carriers. Publication Status: Online-Only, [RefSeq, PubMed]; Silencing DSCAM-AS1 suppresses the growth and invasion of ER-positive breast cancer cells by downregulating both DCTPP1 and QPRT. Erratum:[Aging (Albany NY). 2022 Jan 15;14(1):528-529. doi: 10.18632/aging.203837. PMID: 35050859], [RefSeq, PubMed]; Targeting NAD(+) Biosynthesis Overcomes Panobinostat and Bortezomib-Induced Malignant Glioma Resistance., [RefSeq, PubMed]; This gene encodes a key enzyme in catabolism of quinolinate, an intermediate in the tryptophan-nicotinamide adenine dinucleotide pathway. Quinolinate acts as a most potent endogenous exitotoxin to neurons. Elevation of quinolinate levels in the brain has been linked to the pathogenesis of neurodegenerative disorders such as epilepsy, Alzheimer's disease, and Huntington's disease. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 14,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 2,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q53XW7;Q96G22;Q9BSG6",
        "ec_number_list": [
            {
                "id": "2.4.2.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.2.19",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0004514 nicotinate-nucleotide diphosphorylase (carboxylating) activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0070062 extracellular exosome;GO:1902494 catalytic complex",
        "go_biological_process": "GO:0009435 NAD+ biosynthetic process;GO:0034213 quinolinate catabolic process;GO:0034354 'de novo' NAD+ biosynthetic process from L-tryptophan",
        "synthesized_glycan_count": 0,
        "hit_score": 11.0,
        "record_id": "Q15274-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UHQ9-1",
        "uniprot_id": [
            {
                "id": "NB5R1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UHQ9",
                "type": "external"
            }
        ],
        "mass": 34095.0,
        "length": 305,
        "protein_name": "NADH-cytochrome b5 reductase 1",
        "gene_name": "CYB5R1",
        "organism": "Human",
        "refseq_name": "NADH-cytochrome b5 reductase 1",
        "refseq_ac": [
            {
                "id": "NP_057327",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057327",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CYB5R1; NQO3A2; PRO9865",
        "gene_names_refseq": "B5R.1; B5R1; B5R2; CYB5R1; NQO3A2; humb5R2",
        "protein_names_uniprotkb": "NADH-cytochrome b5 reductase 1; 1.6.2.2; Humb5R2; NAD(P)H:quinone oxidoreductase type 3 polypeptide A2; b5R.1",
        "protein_names_refseq": "NAD(P)H:quinone oxidoreductase type 3, polypeptide A2; NADH-cytochrome b5 reductase 1",
        "tax_id": 9606,
        "disease": "methemoglobinemia (Disease Ontology:DOID:10783)",
        "pathway": " (hsa:51706);  (R-HSA-114608);  (R-HSA-1237044)",
        "pathway_count": 3,
        "publication_count": 96,
        "publication_id_list": "10090333;10529219;10611283;11237011;11606574;12754312;12933803;12975309;1311094;1395;1435334;14630798;14958;15131110;15297306;15501038;1554744;15858218;16303743;16563834;16992238;16994616;17012249;17712059;17990881;19273840;19668749;19913121;20068231;20162361;20230836;21041929;2111324;234739;23481700;23640497;24715725;25576301;25937211;26154972;26992070;27120783;27452731;27600516;28228285;28832583;28834231;29242379;29557506;29786170;30429286;30524438;30620550;3080418;3136125;31844290;32157095;32357974;32387766;32938616;33011882;33298915;33321093;33592498;33912179;33936100;33968037;34087483;34185709;34405274;34509645;35051231;35580925;36010968;37217939;37938771;38665916;40596516;4514311;4647257;4975618;4994926;5656372;6407977;6433979;6457647;6819139;8070313;8300612;8467233;8875343;8972395;9054574;9143858;9336012;9486145",
        "class_list": "glycogene",
        "function": "Catalyzes the reduction of two molecules of cytochrome b5 using NADH as the electron donor., [UniProtKB, UniProtKB]; Data show that cytochrome b5 reductase 1 (CYB5R1) gene expression is strongly linked to epithelial-mesenchymal transition (EMT) in colon cancer., [RefSeq, PubMed]; Membrane Damage during Ferroptosis Is Caused by Oxidation of Phospholipids Catalyzed by the Oxidoreductases POR and CYB5R1., [RefSeq, PubMed]; Microsomal reductase activity in patients with thyroid neoplasms., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 376,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0PK21;B2R8E0;O95329;Q53F73;Q8NCL5;Q9UHJ1",
        "ec_number_list": [
            {
                "id": "1.6.2.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.6.2.2",
                "type": "external"
            },
            {
                "id": "5.3.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.3.4.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0071949 FAD binding;GO:0004128 cytochrome-b5 reductase activity, acting on NAD(P)H;GO:0090524 cytochrome-b5 reductase activity, acting on NADH",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0016126 sterol biosynthetic process;GO:0015701 bicarbonate transport",
        "synthesized_glycan_count": 0,
        "hit_score": 10.0,
        "record_id": "Q9UHQ9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14594-1",
        "uniprot_id": [
            {
                "id": "NCAN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14594",
                "type": "external"
            }
        ],
        "mass": 143093.0,
        "length": 1321,
        "protein_name": "Neurocan core protein",
        "gene_name": "NCAN",
        "organism": "Human",
        "refseq_name": "neurocan core protein precursor",
        "refseq_ac": [
            {
                "id": "NP_004377",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004377",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NCAN; CSPG3; NEUR",
        "gene_names_refseq": "CSPG3; NCAN",
        "protein_names_uniprotkb": "Neurocan core protein; Chondroitin sulfate proteoglycan 3",
        "protein_names_refseq": "chondroitin sulfate proteoglycan 3 (neurocan); neurocan core protein precursor; neurocan core protein; neurocan proteoglycan",
        "tax_id": 9606,
        "disease": "nicotine dependence (Disease Ontology:DOID:0050742); warfarin resistance (Disease Ontology:DOID:0080665); lung cancer (Disease Ontology:DOID:1324)",
        "pathway": " (hsa:1463);  (R-HSA-1971475);  (R-HSA-2022870);  (R-HSA-2022923);  (R-HSA-2024101);  (R-HSA-3000178);  (R-HSA-3560783);  (R-HSA-3560801);  (R-HSA-3595172);  (R-HSA-3595174);  (R-HSA-3595177);  (R-HSA-373760);  (R-HSA-419037);  (R-HSA-4420332)",
        "pathway_count": 14,
        "publication_count": 156,
        "publication_id_list": "10.1101/2023.09.13.557529;10022829;10187838;10339581;10339611;10473568;10506123;10673326;10781596;10781601;10842173;10963998;11056388;11084047;11099377;11139592;11237011;11259413;11414686;11470797;11514575;11551958;11568288;11788602;11877387;12080076;12145278;12163485;12225811;12512856;12522689;12556911;12761225;12765789;12874280;12888274;12907687;1326557;1376317;14715956;14978216;14993226;15057824;15075323;15211654;15215498;15294915;15296743;1544908;15461586;15647514;16000162;16267048;16293224;16493581;16505484;17194707;17227754;17588949;18059411;18316376;18513679;18698629;1907800;19188366;19224584;1928092;1946389;19473117;19661164;19889881;20004762;20166139;20533528;2059554;20691685;20830804;21129727;21129728;21152083;2122463;21642437;21763480;21789315;22134916;22810237;23234360;2364322;23656592;23664117;23664118;23704329;2412224;2420006;2430969;24425863;24443026;25220293;25326458;25521717;25801500;26758079;26758378;27599773;27887608;2809592;28657654;29514872;29557506;2971395;29741879;30410026;30459171;31154438;3134052;32583466;33981976;3468507;35051231;39531497;5822067;6193777;6439184;738706;7490074;7499434;7513709;7527058;7542669;7559467;7628016;7685013;7693733;7852349;8002934;8213840;8262246;8440685;8663515;8798654;8910306;8943283;9223416;9252349;9294172;9341124;9346959;9398268;9506957;9521684;9685393;9795216;9823490;9883891;9892646;9949188",
        "class_list": "glycogene",
        "function": "May modulate neuronal adhesion and neurite growth during development by binding to neural cell adhesion molecules (NG-CAM and N-CAM). Chondroitin sulfate proteoglycan; binds to hyaluronic acid., [UniProtKB]; NCAN genotype is associated with limbic gray matter alterations in healthy and subjects with major depression in brain areas implicated in emotion perception and regulation, [RefSeq, PubMed]; NCAN rs2228603 is not a risk factor for the incidence of NAFLD in Chinese population. The dual and opposite role of T variant in protecting liver with a higher level of HDL was found. Publication Status: Online-Only, [RefSeq, PubMed]; Neurocan genome-wide psychiatric risk variant affects explicit memory performance and hippocampal function in healthy humans., [RefSeq, PubMed]; Neurocan is a chondroitin sulfate proteoglycan thought to be involved in the modulation of cell adhesion and migration.[supplied by OMIM, Jul 2002]., [RefSeq]; This study aims to analyze the influences of single-nucleotide polymorphism in the NCAN-CILP2 region on non-alcoholic fatty liver disease and plasma lipid levels in the Asian and Pacific ethnic groups. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 4,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1664,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 21,
        "disease_count": 3,
        "glyco_site_count": 14,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9UPK6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0030246 carbohydrate binding;GO:0005540 hyaluronic acid binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005796 Golgi lumen;GO:0045202 synapse;GO:0043202 lysosomal lumen",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007417 central nervous system development;GO:0001501 skeletal system development",
        "synthesized_glycan_count": 0,
        "hit_score": 18.5,
        "record_id": "O14594-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000011001.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P13349-1",
        "uniprot_id": [
            {
                "id": "MYF5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P13349",
                "type": "external"
            }
        ],
        "mass": 28296.0,
        "length": 255,
        "protein_name": "Myogenic factor 5",
        "gene_name": "MYF5",
        "organism": "Human",
        "refseq_name": "myogenic factor 5",
        "refseq_ac": [
            {
                "id": "NP_005584",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005584",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYF5; BHLHC2",
        "gene_names_refseq": "EORVA; MYF5; bHLHc2",
        "protein_names_uniprotkb": "Myogenic factor 5; Class C basic helix-loop-helix protein 2; Myf-5; bHLHc2",
        "protein_names_refseq": "class C basic helix-loop-helix protein 2; myf-5; myogenic factor 5",
        "tax_id": 9606,
        "disease": "Duchenne muscular dystrophy (Disease Ontology:DOID:11723); musculoskeletal system disease (Disease Ontology:DOID:17); ophthalmoplegia, external, with rib and vertebral anomalies (MONDO:MONDO:0032565)",
        "pathway": " (hsa:4617);  (R-HSA-525793);  (R-HSA-9839394)",
        "pathway_count": 3,
        "publication_count": 22,
        "publication_id_list": "10330143;10601328;10805738;11782431;12634428;18299279;19564926;20160094;2721498;28080960;29844345;29887215;30467960;31409900;37222488;38927634;9069290;9418854;9461343;9786951;9858528;9988769",
        "class_list": "",
        "function": "Analysis of human rhabdomyosarcoma revealed that MYF5 and MYOD are mutually-exclusively expressed and each is required for sustained tumor growth. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of a Novel Frameshift Variant in MYF5 Leading to External Ophthalmoplegia with Rib and Vertebral Anomalies. Publication Status: Online-Only, [RefSeq, PubMed]; SNAIL silencing allows the re-expression of MYF5 and canonical MYOD binding, promoting alveolar rhabdomyosarcoma cell myogenic differentiation. Publication Status: Online-Only, [RefSeq, PubMed]; The direct role of MYF5 in rib, spine, and extraocular muscle formation in humans., [RefSeq, PubMed]; Transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation (PubMed:29887215). Together with MYOG and MYOD1, co-occupies muscle-specific gene promoter core region during myogenesis. Induces fibroblasts to differentiate into myoblasts. Probable sequence specific DNA-binding protein., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ISR9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0000785 chromatin;GO:0090575 RNA polymerase II transcription regulator complex",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007517 muscle organ development;GO:0035914 skeletal muscle cell differentiation;GO:0007519 skeletal muscle tissue development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.3,
        "record_id": "P13349-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P61599-1",
        "uniprot_id": [
            {
                "id": "NAA20_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P61599",
                "type": "external"
            }
        ],
        "mass": 20368.0,
        "length": 178,
        "protein_name": "N-alpha-acetyltransferase 20",
        "gene_name": "NAA20",
        "organism": "Human",
        "refseq_name": "N-alpha-acetyltransferase 20 isoform a",
        "refseq_ac": [
            {
                "id": "NP_057184",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057184",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAA20; NAT5",
        "gene_names_refseq": "MRT73; NAA20; NAT3P; NAT3; NAT5P; NAT5; dJ1002M8.1",
        "protein_names_uniprotkb": "N-alpha-acetyltransferase 20; 2.3.1.254; Methionine N-acetyltransferase; N-acetyltransferase 5; N-terminal acetyltransferase B complex catalytic subunit NAA20; N-terminal acetyltransferase B complex catalytic subunit NAT5; NatB catalytic subunit; NatB complex subunit NAT5",
        "protein_names_refseq": "N-acetyltransferase 3 homolog; N-acetyltransferase 5 (ARD1 homolog, S. cerevisiae); N-acetyltransferase 5 (GCN5-related, putative); N-acetyltransferase 5, ARD1 subunit (arrest-defective 1, S. cerevisiae, homolog); N-alpha-acetyltransferase 20 isoform a; N-terminal acetyltransferase B complex catalytic subunit NAA20; N-terminal acetyltransferase B complex catalytic subunit NAT5; N-terminal acetyltransferase complex ARD1 subunit; methionine N-acetyltransferase; natB catalytic subunit; natB complex subunit NAT5",
        "tax_id": 9606,
        "disease": "autosomal recessive intellectual developmental disorder 73 (Disease Ontology:DOID:0081233)",
        "pathway": " (hsa:51126)",
        "pathway_count": 1,
        "publication_count": 60,
        "publication_id_list": "11230166;11237011;18570629;19660095;21872626;22424782;22814378;24714562;24715725;25732826;25880248;26154972;26992070;27846572;27862975;28218747;28510447;28904123;29437277;29493099;29557506;30315122;30410026;31217245;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32976911;32983136;33141586;33219302;33298915;33392160;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34230638;34509645;34932366;35051231;35318648;35580925;36010968;36215666;36241641;36284347;37191084;37827343;38335281",
        "class_list": "",
        "function": "Catalytic subunit of the NatB complex which catalyzes acetylation of the N-terminal methionine residues of peptides beginning with Met-Asp, Met-Glu, Met-Asn and Met-Gln (PubMed:34230638). Proteins with cell cycle functions are overrepresented in the pool of NatB substrates. Required for maintaining the structure and function of actomyosin fibers and for proper cellular migration., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB]; Human N-acetyltransferase complexe NatB consists of human N-acetyltransferase 3 and human MDM20. hNAT3 knockdown results in an increase in G(0)/G(1)-phase cells. GeneRIF: hNat3 (NAT5) is the catalytic subunit and hMdm20 the auxiliary subunit of the human NatB N-terminal acetyltransferase complex. This ribosome associated complex acetylates nascent Met-Asp/Glu- polypeptides., [RefSeq, PubMed]; Maturation of NAA20 Aminoterminal End Is Essential to Assemble NatB N-Terminal Acetyltransferase Complex., [RefSeq, PubMed]; Missense NAA20 variants impairing the NatB protein N-terminal acetyltransferase cause autosomal recessive developmental delay, intellectual disability, and microcephaly., [RefSeq, PubMed]; NAA20 recruits Rin2 and promotes triple-negative breast cancer progression by regulating Rab5A-mediated activation of EGFR signaling., [RefSeq, PubMed]; NAT5 is a component of N-acetyltransferase complex B (NatB). Human NatB performs cotranslational N(alpha)-terminal acetylation of methionine residues when they are followed by asparagine (Starheim et al., 2008 [PubMed 18570629]).[supplied by OMIM, Apr 2009]., [RefSeq]; Naa20, the catalytic subunit of NatB complex, contributes to hepatocellular carcinoma by regulating the LKB1-AMPK-mTOR axis., [RefSeq, PubMed]; Sequential CRISPR screening reveals partial NatB inhibition as a strategy to mitigate alpha-synuclein levels in human neurons., [RefSeq, PubMed]; The human NatB complex composed of Naa20 (NAT3) and Naa25 (MDM20) N-terminally acetylates Met-Glu-, Met-Asp-, Met-Asn- and Met-Gln- N-termini, and is important for the structure and function of actomyosin fibers and for proper cellular migration., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NHA3;B2R4G4;Q5TFT7;Q9D7H8;Q9H0Y4;Q9NQH6;Q9Y6D2",
        "ec_number_list": [
            {
                "id": "2.3.1.254",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.254",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004596 protein-N-terminal amino-acid acetyltransferase activity;GO:0120518 protein N-terminal-methionine acetyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0031416 NatB complex",
        "go_biological_process": "GO:0032956 regulation of actin cytoskeleton organization;GO:0006474 N-terminal protein amino acid acetylation;GO:0018002 N-terminal peptidyl-glutamic acid acetylation;GO:0017190 N-terminal peptidyl-aspartic acid acetylation;GO:0017192 N-terminal peptidyl-glutamine acetylation",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "P61599-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q08AG7-1",
        "uniprot_id": [
            {
                "id": "MZT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q08AG7",
                "type": "external"
            }
        ],
        "mass": 8479.0,
        "length": 82,
        "protein_name": "Mitotic-spindle organizing protein 1",
        "gene_name": "MZT1",
        "organism": "Human",
        "refseq_name": "mitotic-spindle organizing protein 1",
        "refseq_ac": [
            {
                "id": "NP_001065243",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001065243",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MZT1; C13orf37; MOZART1",
        "gene_names_refseq": "C13orf37; MOZART1; MZT1",
        "protein_names_uniprotkb": "Mitotic-spindle organizing protein 1; Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1",
        "protein_names_refseq": "mitotic-spindle organizing protein 1; mitotic-spindle organizing protein associated with a ring of gamma-tubulin 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:440145);  (R-HSA-380270);  (R-HSA-380320)",
        "pathway_count": 3,
        "publication_count": 46,
        "publication_id_list": "11956313;12221128;16462731;20360068;22424782;23481700;23921553;24715725;25576301;26154972;26992070;27852835;28851027;29557506;30429286;31844290;32157095;32357974;32387766;32502341;32610146;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34171305;34509645;34561969;34932366;35051231;35561310;36010968;36215666;38609661;39321809;7769006;7790358;8838651",
        "class_list": "",
        "function": "MZT Proteins Form Multi-Faceted Structural Modules in the gamma-Tubulin Ring Complex., [RefSeq, PubMed]; MZT1 is a 'priming factor' for gamma-tubulin ring complex that allows spatial regulation of nucleation., [RefSeq, PubMed]; NMR secondary structure and interactions of recombinant human MOZART1 protein with its binding partner, GCP3, has been presented., [RefSeq, PubMed]; Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:38609661, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:38609661, PubMed:39321809)., [UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5W0P5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0031021 interphase microtubule organizing center;GO:0000931 gamma-tubulin ring complex",
        "go_biological_process": "GO:0090307 mitotic spindle assembly;GO:0007020 microtubule nucleation;GO:0033566 gamma-tubulin complex localization;GO:0051415 microtubule nucleation by interphase microtubule organizing center",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q08AG7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14324-1",
        "uniprot_id": [
            {
                "id": "MYPC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14324",
                "type": "external"
            }
        ],
        "mass": 128072.0,
        "length": 1141,
        "protein_name": "Myosin-binding protein C, fast-type",
        "gene_name": "MYBPC2",
        "organism": "Human",
        "refseq_name": "myosin-binding protein C, fast-type",
        "refseq_ac": [
            {
                "id": "NP_004524",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004524",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYBPC2; MYBPCF",
        "gene_names_refseq": "MYBPC2; MYBPCF; MYBPC; fsMyBP-C",
        "protein_names_uniprotkb": "Myosin-binding protein C, fast-type; C-protein, skeletal muscle fast isoform; Fast MyBP-C",
        "protein_names_refseq": "fast MyBP-C; fast skeletal-type muscle myosin-binding-protein C; fast-type muscle myosin-binding-protein C; myosin binding protein C, fast type; myosin-binding protein C, fast-type; testicular tissue protein Li 126",
        "tax_id": 9606,
        "disease": "congenital heart disease (Disease Ontology:DOID:1682); myopathy (Disease Ontology:DOID:423)",
        "pathway": " (hsa:4606);  (R-HSA-390522)",
        "pathway_count": 2,
        "publication_count": 29,
        "publication_id_list": "10747208;12386147;17081983;17876814;20605413;20740642;23481700;24715725;25576301;25892735;26154972;26992070;28228285;28832583;29242379;29769354;30315122;31844290;32357974;33141586;33298915;33499774;33912179;33936100;34019948;35051231;35580925;37217939;8375400",
        "class_list": "",
        "function": "Identification of interactions between domains of Myosin binding protein-C that are modulated by hypertrophic cardiomyopathy missense mutations., [RefSeq, PubMed]; MYBPC2 and MYL1 as Significant Gene Markers for Rhabdomyosarcoma., [RefSeq, PubMed]; The CD-loop is a natively unfolded sequence with a likely coupling between folding and ligand binding., [RefSeq, PubMed]; The mean methylation level of CpGs was significantly higher in MYBPC3 than MYBPC2., [RefSeq, PubMed]; The patients with a frameshift deletion mutation of MyBPC may develop LV systolic dysfunction and suffer from cardiovascular events through mid-life and beyond., [RefSeq, PubMed]; Thick filament-associated protein located in the crossbridge region of vertebrate striated muscle a bands. In vitro it binds MHC, F-actin and native thin filaments, and modifies the activity of actin-activated myosin ATPase. It may modulate muscle contraction or may play a more structural role., [UniProtKB]; This gene encodes a member of the myosin-binding protein C family. This family includes the fast-, slow- and cardiac-type isoforms, each of which is a myosin-associated protein found in the cross-bridge-bearing zone (C region) of A bands in striated muscle. The protein encoded by this locus is referred to as the fast-type isoform. Mutations in the related but distinct genes encoding the slow-type and cardiac-type isoforms have been associated with distal arthrogryposis, type 1 and hypertrophic cardiomyopathy, respectively. [provided by RefSeq, Jul 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 40,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4G9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0008307 structural constituent of muscle",
        "go_cellular_component": "GO:0005829 cytosol;GO:0032982 myosin filament;GO:0031430 M band",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0045214 sarcomere organization",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "Q14324-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q69YL0-1",
        "uniprot_id": [
            {
                "id": "NCAS2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q69YL0",
                "type": "external"
            }
        ],
        "mass": 10891.0,
        "length": 99,
        "protein_name": "Protein NCBP2AS2",
        "gene_name": "NCBP2AS2",
        "organism": "Human",
        "refseq_name": "protein NCBP2AS2",
        "refseq_ac": [
            {
                "id": "NP_001342172",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001342172",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NCBP2AS2; HIAR",
        "gene_names_refseq": "HIAR; KRASIM; NCBP2-AS2; NCBP2AS2",
        "protein_names_uniprotkb": "Protein NCBP2AS2; Hypoxia-induced angiogenesis regulator; NCBP2 antisense gene protein 2",
        "protein_names_refseq": "KRAS-interacting microprotein; NCBP2 antisense RNA 2 (head to head); NCBP2 antisense gene protein 2; hypoxia-induced angiogenesis regulator; protein NCBP2AS2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:152217)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "25418920;27846572;28649982;28904123;29493099;30723174;31844290;32265295;33936100;33968037",
        "class_list": "",
        "function": "The uncharacterized protein hypoxia-induced angiogenesis regulator (NCBP2-AS2) that was renamed HIAR (hypoxia-induced angiogenesis regulator) was the protein most increased in abundance in hypoxic cancer-associated fibroblasts (CAFs). Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q69YL0-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6NSJ0-1",
        "uniprot_id": [
            {
                "id": "MYORG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6NSJ0",
                "type": "external"
            }
        ],
        "mass": 81087.0,
        "length": 714,
        "protein_name": "Alpha-galactosidase MYORG",
        "gene_name": "MYORG",
        "organism": "Human",
        "refseq_name": "alpha-galactosidase MYORG",
        "refseq_ac": [
            {
                "id": "NP_065753",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_065753",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYORG; KIAA1161; NET37",
        "gene_names_refseq": "IBGC7; KIAA1161; MYORG; NET37",
        "protein_names_uniprotkb": "Alpha-galactosidase MYORG; 3.2.1.22; Myogenesis regulating glycosidase; Nuclear envelope transmembrane protein 37",
        "protein_names_refseq": "alpha-galactosidase MYORG; myogenesis regulating glycosidase (putative); nuclear envelope transmembrane protein 37",
        "tax_id": 9606,
        "disease": "basal ganglia calcification (Disease Ontology:DOID:0060230); basal ganglia calcification, idiopathic, 7, autosomal recessive (MONDO:MONDO:0032673)",
        "pathway": " (hsa:57462)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;17081983;19159218;19204726;19706595;23481700;24190977;24715725;26758079;26811146;28904123;29242379;29393594;29493099;29557506;29741879;29786170;29789417;29910000;30315122;30429286;30460687;30589467;30656188;30895394;31009047;31154438;31844290;32357974;32896900;32938616;33141586;33298915;33592498;33912179;33968037;34171305;34185709;34346093;34357683;35051231;36010968;36129849;36215666;36241641;37074911;37680026;39180105",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "Alpha-galactosidase with unusual specificity for the Gal-alpha1,4-Glc structure, whose in vivo substrate is still unknown (PubMed:36129849). Promotes myogenesis by activating AKT signaling through the maturation and secretion of IGF2 (By similarity)., [UniProtKB, UniProtKB, PubMed]; Fahr's disease linked to a novel mutation in MYORG variants manifesting as paroxysmal limb stiffness and dysarthria: Case report and literature review. Review article, [RefSeq, PubMed]; Findings provide strong evidence that loss-of-function mutations of MYORG cause brain calcification in humans. Compound heterozygous or homozygous mutations of MYORG co-segregated completely with primary familial brain calcification in six families., [RefSeq, PubMed]; Genetic and pathophysiological insights from autopsied patient with primary familial brain calcification: novel MYORG variants and astrocytic implications. Publication Status: Online-Only, [RefSeq, PubMed]; MYORG as a novel causative gene for primary familial brain calcification, [RefSeq, PubMed]; MYORG gene disease-causing variants in a family with primary familial brain calcification presenting with stroke-like episodes., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Paroxysmal Kinesigenic Dyskinesia Secondary to Brain Calcification with a Homozygous MYORG Mutation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 7,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 1103,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 13,
        "disease_count": 2,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T587;Q5T588;Q9ULQ9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004557 alpha-galactosidase activity;GO:0016798 hydrolase activity, acting on glycosyl bonds",
        "go_cellular_component": "GO:0031965 nuclear membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0005975 carbohydrate metabolic process;GO:0048741 skeletal muscle fiber development;GO:0043568 positive regulation of insulin-like growth factor receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q6NSJ0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000000001.100.10100",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6NSW7-1",
        "uniprot_id": [
            {
                "id": "NANP8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6NSW7",
                "type": "external"
            }
        ],
        "mass": 34673.0,
        "length": 305,
        "protein_name": "Homeobox protein NANOGP8",
        "gene_name": "NANOGP8",
        "organism": "Human",
        "refseq_name": "homeobox protein NANOGP8",
        "refseq_ac": [
            {
                "id": "NP_001342210",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001342210",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NANOGP8",
        "gene_names_refseq": "NANOGP8; PN8",
        "protein_names_uniprotkb": "Homeobox protein NANOGP8",
        "protein_names_refseq": "homeobox protein NANOGP8; nanog-like protein; putative homeobox protein NANOGP8",
        "tax_id": 9606,
        "disease": "colon cancer (Disease Ontology:DOID:219)",
        "pathway": " (hsa:388112)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "15233988;16469101;16623708;20581802;23173096;26087476;28033430;28453235;29689047;34165720;39894887",
        "class_list": "",
        "function": "A Restriction Endonuclease-Based Assay to Distinguish NANOGP8 Retrogene from Parental NANOG., [RefSeq, PubMed]; LGR5-expressing fraction of CD54+ cells represents gastric cancer CSCs, in which LGR5 is closely associated with stemness and EMT core genes Publication Status: Online-Only, [RefSeq, PubMed]; May act as a transcription regulator (By similarity). When overexpressed, promotes entry of cells into S phase and cell proliferation., [UniProtKB, PubMed]; NANOGP8 is expressed in primary human glioblastoma and is required for glioblastoma growth in xenograft assay in mice, [RefSeq, PubMed]; NANOGP8 is the main regulator of gastric cancer stem cells. NANOGP8 is correlated with cell proliferation, migration, invasion, clonogenic capacity, beta-catenin accumulation in nucleus, and chemoresistance in gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Results indicate that NANOG and NANOGP8 proteins are expressed in prostate cancer cell lines, and NANOG and NANOGP8 equally contribute to the high malignant potential of prostate cancer., [RefSeq, PubMed]; Studies demonstrated a paracrine role for endothelial cells in regulating the cancer stem cells phenotype and chemoresistance in colorectal cancer cells by AKT-mediated induction of NANOGP8., [RefSeq, PubMed]; This gene represents a transcribed retrogene of the Nanog homeobox gene. The putative encoded protein may participate in reprogramming of cancer cells. In vitro studies using a recombinant protein have shown that the protein localizes to the nucleus and can promote cell proliferation, similar to the Nanog protein. [provided by RefSeq, Sep 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "J7H3Y9;J7H3Z5;J7H408;J7H412;J7H416;J7H738;J7H745;J7H749;J7H9S6;J7H9T4;J7HAW9;J7HAX1;J7HAX8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008284 positive regulation of cell population proliferation;GO:0030154 cell differentiation;GO:0019827 stem cell population maintenance",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q6NSW7-1",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86YV6-1",
        "uniprot_id": [
            {
                "id": "MYLK4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86YV6",
                "type": "external"
            }
        ],
        "mass": 44508.0,
        "length": 388,
        "protein_name": "Myosin light chain kinase family member 4",
        "gene_name": "MYLK4",
        "organism": "Human",
        "refseq_name": "myosin light chain kinase family member 4 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001012418",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012418",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYLK4; SGK085",
        "gene_names_refseq": "MLCK4; MYLK4; SgK085",
        "protein_names_uniprotkb": "Myosin light chain kinase family member 4; 2.7.11.1; SgK085; Sugen kinase 85",
        "protein_names_refseq": "caMLCK like; myosin light chain kinase family member 4 isoform 1; sugen kinase 85",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:340156)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "11237011;12471243;17344846;33980265;35051231;39894887",
        "class_list": "",
        "function": "MYLK4 promotes tumor progression through the activation of epidermal growth factor receptor signaling in osteosarcoma. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RUC0;Q5TAW2",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
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        "publication_id_list": "10023775;10209961;10219247;10369418;10510379;10586089;10716450;10804184;10867011;11058569;11077116;11084045;11104795;11120780;11237011;11278437;11278729;11356008;11404481;11463377;11751684;11855863;11960372;12065233;12223527;12242343;12600988;12787504;12787505;12832402;14634100;14681828;14688391;14712222;14990856;15108323;15110706;15116091;15233988;15261459;15277698;15342930;15342941;15493035;15513931;15582778;15584925;15625129;15695770;15743839;15805299;15860457;15869882;15881652;15950906;15955829;15982323;15983365;15988017;16000880;16007214;16048438;16107692;16153702;16205632;16236134;16391521;16397018;16397896;16451196;16510571;16540365;16606674;16670092;16846370;16862074;16954206;16978057;17068183;1715580;17204602;17267691;17427945;17458857;17506876;17567999;17572495;17572666;17580084;17628018;18029452;18035408;18042803;18212089;18243101;18353781;18366076;18388306;18447642;18550259;18644974;18653770;18687985;18729794;18824471;19057969;19124156;19128516;19151334;19185846;19329776;19397496;19440552;19489980;19522013;19544431;19604364;19688839;19696931;19755485;19829295;19966271;20027182;20074535;20493732;20505756;20505821;20526341;20549704;20616345;20624125;20837710;20872845;20925113;20953172;21049019;21102457;21245162;21252155;21630377;21689689;21730069;21791611;21816365;21924763;21937440;21969378;21994466;22015605;22046235;22178155;22205702;22210884;22215994;22327294;22383755;22402664;22493428;22693070;22851691;22855527;22887036;22988117;23086340;23124025;23172665;23178592;23455323;23555662;23708658;23827706;23827708;23967200;24097101;24218367;24678451;24743777;24793005;25234944;25543152;25693565;25825768;25921273;25936800;26189426;26687479;27052315;28457890;28985527;29091993;29234012;29713018;30590035;30595535;32127035;32448362;33470497;33608411;34065661;35411086;37461005;37774079;38796740;38977352;39175947;7510216;7512451;7529288;7545930;7555726;7688835;7795521;7796300;7898939;7907877;8085155;8602263;8621622;8663118;8668165;8797861;8816495;9000051;9013879;9354794;9417125;9651359;9723655;9736340;9807024;9822675;9874564",
        "class_list": "",
        "function": "Clinicopathologic Impact of NANOG, ZEB1, and EpCAM Biomarkers on Prognosis of Serous Ovarian Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; High NANOG expression correlates with worse patients' survival in esophageal adenocarcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; NANOG regulate the JAK/STAT3 pathway to promote trophoblast cell migration and epithelial-mesenchymal transition (EMT) in hypertensive disorders of pregnancy (HDP) through protein interaction with CDK1., [RefSeq, PubMed]; Secreted factors from M1 macrophages drive prostate cancer stem cell plasticity by upregulating NANOG, SOX2, and CD44 through NFkappaB-signaling. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a DNA binding homeobox transcription factor involved in embryonic stem (ES) cell proliferation, renewal, and pluripotency. The encoded protein can block ES cell differentiation and can also autorepress its own expression in differentiating cells. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2015]., [RefSeq]; Transcription regulator involved in inner cell mass and embryonic stem (ES) cells proliferation and self-renewal. Imposes pluripotency on ES cells and prevents their differentiation towards extraembryonic endoderm and trophectoderm lineages. Blocks bone morphogenetic protein-induced mesoderm differentiation of ES cells by physically interacting with SMAD1 and interfering with the recruitment of coactivators to the active SMAD transcriptional complexes. Acts as a transcriptional activator or repressor. Binds optimally to the DNA consensus sequence 5'-TAAT[GT][GT]-3' or 5'-[CG][GA][CG]C[GC]ATTAN[GC]-3'. Binds to the POU5F1/OCT4 promoter (PubMed:25825768). Able to autorepress its expression in differentiating (ES) cells: binds to its own promoter following interaction with ZNF281/ZFP281, leading to recruitment of the NuRD complex and subsequent repression of expression. When overexpressed, promotes cells to enter into S phase and proliferation., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; [High expression of the stemness-associated molecule Nanog in esophageal squamous cell carcinoma tissues promotes tumor invasion and metastasis by activating the TGF-beta signaling pathway]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "D3DUU4;Q2TTG0;Q6JZS5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0000976 transcription cis-regulatory region binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0000785 chromatin",
        "go_biological_process": "GO:2000648 positive regulation of stem cell proliferation;GO:0001714 endodermal cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation",
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        "hit_score": 23.3,
        "record_id": "Q9H9S0-1",
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    },
    {
        "uniprot_canonical_ac": "Q9NZM1-1",
        "uniprot_id": [
            {
                "id": "MYOF_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZM1",
                "type": "external"
            }
        ],
        "mass": 234709.0,
        "length": 2061,
        "protein_name": "Myoferlin",
        "gene_name": "MYOF",
        "organism": "Human",
        "refseq_name": "myoferlin isoform a",
        "refseq_ac": [
            {
                "id": "NP_038479",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_038479",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYOF; FER1L3; KIAA1207",
        "gene_names_refseq": "FER1L3; HAE7; MYOF",
        "protein_names_uniprotkb": "Myoferlin; Fer-1-like protein 3",
        "protein_names_refseq": "fer-1-like 3, myoferlin; fer-1-like family member 3; fer-1-like protein 3; myoferlin isoform a",
        "tax_id": 9606,
        "disease": "colitis (Disease Ontology:DOID:0060180); acute necrotizing pancreatitis (Disease Ontology:DOID:0080998); brain small vessel disease (Disease Ontology:DOID:0112313); Alzheimer's disease (Disease Ontology:DOID:10652); limb-girdle muscular dystrophy (Disease Ontology:DOID:11724); Sjogren's syndrome (Disease Ontology:DOID:12894); Kawasaki disease (Disease Ontology:DOID:13378); hereditary angioedema (Disease Ontology:DOID:14735); atherosclerosis (Disease Ontology:DOID:1936); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); atopic dermatitis (Disease Ontology:DOID:3310); anti-basement membrane glomerulonephritis (Disease Ontology:DOID:4780); human immunodeficiency virus infectious disease (Disease Ontology:DOID:526); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); systemic juvenile rheumatoid arthritis (Disease Ontology:DOID:676); ulcerative colitis (Disease Ontology:DOID:8577); intermediate coronary syndrome (Disease Ontology:DOID:8805); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); angioedema, hereditary, 7 (MONDO:MONDO:0025713)",
        "pathway": " (hsa:26509)",
        "pathway_count": 1,
        "publication_count": 100,
        "publication_id_list": "10607832;10995573;11237011;11959863;15302935;17081983;17702744;18083107;18495154;18502764;18578522;18669648;19608861;19651622;19664994;20058876;20068231;21136679;22299025;23186163;23481700;24687993;25576301;25645385;25802875;26707827;26768311;26853435;27452731;27726376;27846572;28832583;28904123;29093164;29242379;29331515;29393594;29493099;29508533;29557506;29786170;29789417;30379171;30429286;30484775;30779550;30833945;31154438;31222486;31844290;31848261;32125861;32157095;32161166;32350084;32357974;32488085;32502341;32542751;32897882;32938616;32983136;33043033;33141586;33214551;33298915;33465208;33592498;33912179;33968037;33981976;34019948;34087483;34171305;34357683;34405274;34725712;35051231;35083852;35154160;35318648;35494241;35561310;35580925;35984564;36010968;36215666;36241641;36284347;36827461;37217939;37434585;37938771;38253038;38253296;38368370;38665916;39302247;39894887;41018975",
        "class_list": "",
        "function": "A missense variant in MYOF is associated with ARVC and sudden cardiac death., [RefSeq, PubMed]; Calcium/phospholipid-binding protein that plays a role in the plasmalemma repair mechanism of endothelial cells that permits rapid resealing of membranes disrupted by mechanical stress. Involved in endocytic recycling. Implicated in VEGF signal transduction by regulating the levels of the receptor KDR (By similarity)., [UniProtKB]; HBZ upregulates myoferlin expression to facilitate HTLV-1 infection. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of myoferlin as a mitochondria-associated membranes component required for calcium signaling in PDAC cell lines. Publication Status: Online-Only, [RefSeq, PubMed]; Impairment of APPL1/Myoferlin facilitates adipogenic differentiation of mesenchymal stem cells by blocking autophagy flux in osteoporosis. Publication Status: Online-Only, [RefSeq, PubMed]; Mutations in dysferlin, a protein associated with the plasma membrane, can cause muscle weakness that affects both proximal and distal muscles. The protein encoded by this gene is a type II membrane protein that is structurally similar to dysferlin. It is a member of the ferlin family and associates with both plasma and nuclear membranes. The protein contains C2 domains that play a role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Two transcript variants encoding different isoforms have been found for this gene. Other possible variants have been detected, but their full-length nature has not been determined. [provided by RefSeq, Dec 2008]., [RefSeq]; Tetraspanin CD82 Associates with Trafficking Vesicle in Muscle Cells and Binds to Dysferlin and Myoferlin., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "B3KQN5;Q5VWW2;Q5VWW3;Q5VWW4;Q5VWW5;Q7Z642;Q8IWH0;Q9HBU3;Q9NZM0;Q9ULL3;Q9Y4U4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005543 phospholipid binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0070062 extracellular exosome;GO:0031410 cytoplasmic vesicle",
        "go_biological_process": "GO:0001778 plasma membrane repair;GO:0006936 muscle contraction;GO:0008015 blood circulation;GO:0046928 regulation of neurotransmitter secretion",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q9NZM1-1",
        "record_type": "protein",
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    },
    {
        "uniprot_canonical_ac": "Q9Y2G1-1",
        "uniprot_id": [
            {
                "id": "MYRF_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y2G1",
                "type": "external"
            }
        ],
        "mass": 124397.0,
        "length": 1151,
        "protein_name": "Myelin regulatory factor",
        "gene_name": "MYRF",
        "organism": "Human",
        "refseq_name": "myelin regulatory factor isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001120864",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120864",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MYRF; C11orf9; KIAA0954; MRF",
        "gene_names_refseq": "11orf9; C11orf9; CUGS; MMERV; MRF; MYRF; NNO1; Ndt80; pqn-47",
        "protein_names_uniprotkb": "Myelin regulatory factor; 3.4.-.-; Myelin gene regulatory factor",
        "protein_names_refseq": "myelin gene regulatory factor; myelin regulatory factor isoform 2 precursor",
        "tax_id": 9606,
        "disease": "nanophthalmos (Disease Ontology:DOID:0080634); primary angle-closure glaucoma (Disease Ontology:DOID:1405); cerebral infarction (Disease Ontology:DOID:3526); congenital diaphragmatic hernia (Disease Ontology:DOID:3827); eye disease (Disease Ontology:DOID:5614); hyperopia (Disease Ontology:DOID:9834); encephalitis/encephalopathy, mild, with reversible myelin vacuolization (MONDO:MONDO:0020853); cardiac-urogenital syndrome (MONDO:MONDO:0032653)",
        "pathway": " (hsa:745)",
        "pathway_count": 1,
        "publication_count": 51,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;10828591;11237011;19608861;23584533;23966832;25813380;25892735;26758079;28514659;28855257;29242379;29265453;29446546;29557506;29729323;29769354;30070761;30315122;30459171;30532227;31048900;31217245;31266062;31611695;31844290;32157095;32350084;32983136;33592498;33691108;33717175;33864620;33912179;33968037;33981976;34087483;34171305;34357683;34433824;35051231;35136345;35251023;35580925;36010968;36129575;36241641;36284347;36695166;9615227",
        "class_list": "",
        "function": "Constitutes a precursor of the transcription factor. Mediates the autocatalytic cleavage that releases the Myelin regulatory factor, N-terminal component that specifically activates transcription of central nervous system (CNS) myelin genes (PubMed:23966832)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Evaluation of MYRF as a candidate gene for primary angle closure glaucoma. Publication Status: Online-Only, [RefSeq, PubMed]; MYRF: A Mysterious Membrane-Bound Transcription Factor Involved in Myelin Development and Human Diseases., [RefSeq, PubMed]; Membrane-bound part that has no transcription factor activity and remains attached to the endoplasmic reticulum membrane following cleavage., [UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a transcription factor that is required for central nervous system myelination and may regulate oligodendrocyte differentiation. It is thought to act by increasing the expression of genes that effect myelin production but may also directly promote myelin gene expression. Loss of a similar gene in mouse models results in severe demyelination. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Nov 2014]., [RefSeq]; Transcription factor that specifically activates expression of myelin genes such as MBP, MOG, MAG, DUSP15 and PLP1 during oligodendrocyte (OL) maturation, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Specifically recognizes and binds DNA sequence 5'-CTGGYAC-3' in the regulatory regions of myelin-specific genes and directly activates their expression. Not only required during oligodendrocyte differentiation but is also required on an ongoing basis for the maintenance of expression of myelin genes and for the maintenance of a mature, viable oligodendrocyte phenotype (PubMed:23966832)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Truncation mutations in MYRF underlie primary angle closure glaucoma., [RefSeq, PubMed]; Two sisters with cardiac-urogenital syndrome secondary to pathogenic splicing variant in the MYRF gene with unaffected parents: A case of gonadal mosaicism?, [RefSeq, PubMed]",
        "predicted_glycosites": 4,
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        "secondary_ac_list": "O43582;Q9P1Q6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0008233 peptidase activity;GO:0003677 DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0022010 central nervous system myelination;GO:0048714 positive regulation of oligodendrocyte differentiation;GO:0045893 positive regulation of DNA-templated transcription;GO:0042220 response to cocaine",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q9Y2G1-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "E5RHQ5-1",
        "uniprot_id": [
            {
                "id": "NPB11_HUMAN",
                "url": "https://www.uniprot.org/uniprot/E5RHQ5",
                "type": "external"
            }
        ],
        "mass": 129208.0,
        "length": 1161,
        "protein_name": "Nuclear pore complex-interacting protein family member B11",
        "gene_name": "NPIPB11",
        "organism": "Human",
        "refseq_name": "nuclear pore complex-interacting protein family member B11",
        "refseq_ac": [
            {
                "id": "NP_001297066",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001297066",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NPIPB11",
        "gene_names_refseq": "NPIPB11; NPIP",
        "protein_names_uniprotkb": "Nuclear pore complex-interacting protein family member B11",
        "protein_names_refseq": "NPIP-like locus; hepatitis B virus pre-pre-S promoter DNA-binding protein; nuclear pore complex-interacting protein family member B11; pps22-1 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:728888)",
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        "publication_count": 2,
        "publication_id_list": "11237011;35494241",
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        "record_id": "E5RHQ5-1",
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        "filter_code": "0000000.1000101.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NFF2-1",
        "uniprot_id": [
            {
                "id": "NP1L6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NFF2",
                "type": "external"
            }
        ],
        "mass": 12045.0,
        "length": 107,
        "protein_name": "Putative nucleosome assembly protein 1-like 6",
        "gene_name": "NAP1L6P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "NAP1L6P; NAP1L6",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative nucleosome assembly protein 1-like 6",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006334 nucleosome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A6NFF2-1",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TAT5-1",
        "uniprot_id": [
            {
                "id": "NEIL3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TAT5",
                "type": "external"
            }
        ],
        "mass": 67769.0,
        "length": 605,
        "protein_name": "Endonuclease 8-like 3",
        "gene_name": "NEIL3",
        "organism": "Human",
        "refseq_name": "endonuclease 8-like 3",
        "refseq_ac": [
            {
                "id": "NP_060718",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060718",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NEIL3",
        "gene_names_refseq": "FGP2; FPG2; NEI3; NEIL3; ZGRF3; hFPG2; hNEI3",
        "protein_names_uniprotkb": "Endonuclease 8-like 3; 3.2.2.-; 4.2.99.18; DNA glycosylase FPG2; DNA glycosylase/AP lyase Neil3; Endonuclease VIII-like 3; Nei-like protein 3",
        "protein_names_refseq": "DNA glycosylase FPG2; DNA glycosylase hFPG2; DNA glycosylase/AP lyase Neil3; endonuclease 8-like 3; endonuclease VIII-like 3; nei endonuclease VIII-like 3; nei-like protein 3; zinc finger, GRF-type containing 3",
        "tax_id": 9606,
        "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:55247);  (R-HSA-110328);  (R-HSA-110329);  (R-HSA-110330);  (R-HSA-110331);  (R-HSA-9629232);  (R-HSA-9636003)",
        "pathway_count": 7,
        "publication_count": 97,
        "publication_id_list": "10074426;10706276;10882850;10930409;11056019;11237011;11904416;12097317;12140329;12200441;12433996;12456671;12718543;15341901;16221681;16428305;19121397;19170771;1924375;19426544;21722948;22365498;22544926;22569481;22645359;22848106;22962365;23186163;23755964;25418920;25576301;25892735;26095805;26375851;26929215;26992070;27354518;27693351;27760045;27869121;28514659;28649982;28832583;28854357;28904123;29234069;29242379;29393594;29493099;29769354;30379171;30524438;30620550;31844290;32265295;32357974;32387766;32488085;32502341;32897882;33633747;33691108;33717175;33750389;33912179;33921035;33936100;33968037;33981976;34171305;34509645;35031058;35051231;35580925;36010968;36241641;36581221;37872095;37992567;7479006;8016081;8110764;8218289;8284199;8407958;8475094;8662714;9187114;9207108;9223305;9223306;9321410;9430628;9705289;9790531;9811839;9890904",
        "class_list": "",
        "function": "CircNEIL3 regulatory loop promotes pancreatic ductal adenocarcinoma progression via miRNA sponging and A-to-I RNA-editing. Erratum:[Mol Cancer. 2022 Aug 19;21(1):165. doi: 10.1186/s12943-022-01636-3. PMID: 35986360] Publication Status: Online-Only, [RefSeq, PubMed]; DNA glycosylase which prefers single-stranded DNA (ssDNA), or partially ssDNA structures such as bubble and fork structures, to double-stranded DNA (dsDNA) (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). Mediates interstrand cross-link repair in response to replication stress: acts by mediating DNA glycosylase activity, cleaving one of the two N-glycosyl bonds comprising the interstrand cross-link, which avoids the formation of a double-strand break but generates an abasic site that is bypassed by translesion synthesis polymerases (By similarity). In vitro, displays strong glycosylase activity towards the hydantoin lesions spiroiminodihydantoin (Sp) and guanidinohydantoin (Gh) in both ssDNA and dsDNA; also recognizes FapyA, FapyG, 5-OHU, 5-OHC, 5-OHMH, Tg and 8-oxoA lesions in ssDNA (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). No activity on 8-oxoG detected (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). Also shows weak DNA-(apurinic or apyrimidinic site) lyase activity (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964). In vivo, appears to be the primary enzyme involved in removing Sp and Gh from ssDNA in neonatal tissues (PubMed:12433996, PubMed:19170771, PubMed:22569481, PubMed:23755964)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; Deficiency of NEIL3 Enhances the Chemotherapy Resistance of Prostate Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; EWSR1-induced circNEIL3 promotes glioma progression and exosome-mediated macrophage immunosuppressive polarization via stabilizing IGF2BP3. Publication Status: Online-Only, [RefSeq, PubMed]; HFPG1 and hFPG2 repair 8-oxoguanine and other DNA oxidation products. (hFPG1 and hFPG2), [RefSeq, PubMed]; NEIL3 belongs to a class of DNA glycosylases homologous to the bacterial Fpg/Nei family. These glycosylases initiate the first step in base excision repair by cleaving bases damaged by reactive oxygen species and introducing a DNA strand break via the associated lyase reaction (Bandaru et al., 2002 [PubMed 12509226]).[supplied by OMIM, Mar 2008]., [RefSeq]; NEIL3 promotes cell proliferation of ccRCC via the cyclin D1-Rb-E2F1 feedback loop regulation., [RefSeq, PubMed]; [Overexpression of Nei endonuclease VIII-like protein 3 in hepatocellular carcinoma indicates increased levels of immune infiltration and an unfavorable prognosis]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2PPJ3;Q8NG51;Q9NV95",
        "ec_number_list": [
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "3.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.2.-",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "4.2.99.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.-",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "1.14.11.51",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.51",
                "type": "external"
            },
            {
                "id": "1.14.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.-",
                "type": "external"
            },
            {
                "id": "1.14.11.33",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.33",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0003684 damaged DNA binding;GO:0019104 DNA N-glycosylase activity;GO:0003690 double-stranded DNA binding;GO:0003906 DNA-(apurinic or apyrimidinic site) endonuclease activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005694 chromosome",
        "go_biological_process": "GO:0006284 base-excision repair;GO:0045007 depurination;GO:0000012 single strand break repair;GO:0036297 interstrand cross-link repair;GO:0006285 base-excision repair, AP site formation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.2,
        "record_id": "Q8TAT5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BS92-1",
        "uniprot_id": [
            {
                "id": "NPS3B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BS92",
                "type": "external"
            }
        ],
        "mass": 28313.0,
        "length": 247,
        "protein_name": "Protein NipSnap homolog 3B",
        "gene_name": "NIPSNAP3B",
        "organism": "Human",
        "refseq_name": "protein NipSnap homolog 3B",
        "refseq_ac": [
            {
                "id": "NP_060846",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060846",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NIPSNAP3B; NIPSNAP3",
        "gene_names_refseq": "FP944; NIPSNAP3B; NIPSNAP3; SNAP1",
        "protein_names_uniprotkb": "Protein NipSnap homolog 3B; NipSnap3B; SNAP1",
        "protein_names_refseq": "protein NipSnap homolog 3B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55335)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "11237011;11352567;25892735;28832583;28904123;29557506;29769354;31154438;32897882;33717175;33912179;33968037",
        "class_list": "",
        "function": "NIPSNAP3B belongs to a family of proteins with putative roles in vesicular trafficking (Buechler et al., 2004 [PubMed 15177564]).[supplied by OMIM, Mar 2008]., [RefSeq]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q5VX30;Q9NUM2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005739 mitochondrion",
        "go_biological_process": "GO:0000423 mitophagy",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q9BS92-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0DM63-1",
        "uniprot_id": [
            {
                "id": "NPIA8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0DM63",
                "type": "external"
            }
        ],
        "mass": 42230.0,
        "length": 369,
        "protein_name": "Nuclear pore complex-interacting protein family member A8",
        "gene_name": "NPIPA8",
        "organism": "Human",
        "refseq_name": "nuclear pore complex-interacting protein family member A7",
        "refseq_ac": [
            {
                "id": "NP_001269436",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001269436",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NPIPA8",
        "gene_names_refseq": "NPIPA7; NPIPA8",
        "protein_names_uniprotkb": "Nuclear pore complex-interacting protein family member A8",
        "protein_names_refseq": "Nuclear pore complex-interacting protein family member A8; nuclear pore complex-interacting protein family member A7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:101059938);  (hsa:101059953)",
        "pathway_count": 2,
        "publication_count": 3,
        "publication_id_list": "11237011;29242379;31092671",
        "class_list": "",
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        "total_reported_n_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "P0DM63-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6P582-1",
        "uniprot_id": [
            {
                "id": "MZT2A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P582",
                "type": "external"
            }
        ],
        "mass": 16221.0,
        "length": 158,
        "protein_name": "Mitotic-spindle organizing protein 2A",
        "gene_name": "MZT2A",
        "organism": "Human",
        "refseq_name": "mitotic-spindle organizing protein 2A",
        "refseq_ac": [
            {
                "id": "NP_001078834",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001078834",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MZT2A; FAM128A; MOZART2A",
        "gene_names_refseq": "FAM128A; MOZART2A; MZT2A",
        "protein_names_uniprotkb": "Mitotic-spindle organizing protein 2A; Mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A",
        "protein_names_refseq": "family with sequence similarity 128, member A; mitotic-spindle organizing protein 2A; mitotic-spindle organizing protein associated with a ring of gamma-tubulin 2A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:653784);  (R-HSA-380270);  (R-HSA-380320)",
        "pathway_count": 3,
        "publication_count": 39,
        "publication_id_list": "11237011;11956313;12221128;16462731;19913121;20360068;20628086;20861304;23481700;23921553;25469497;25576301;25645385;26154972;26992070;28063628;28228285;28832583;28834231;29242379;29331515;29393594;29508533;29632046;29786170;30315122;30524438;31217245;32265295;32610146;33298915;33592498;33754417;33936100;34019948;39321809;7769006;7790358;8838651",
        "class_list": "",
        "function": "Data show that depletion of GCP8 specifically affects the organization of the interphase microtubule network., [RefSeq, PubMed]; MZT Proteins Form Multi-Faceted Structural Modules in the gamma-Tubulin Ring Complex., [RefSeq, PubMed]; MZT2A promotes NSCLC viability and invasion by increasing Akt phosphorylation via the MOZART2 domain. Erratum:[Cancer Sci. 2025 Nov 18. doi: 10.1111/cas.70271. PMID: 41254876], [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Required for the recruitment and the assembly of the gamma-tubulin ring complex (gTuRC) at the centrosome (PubMed:20360068, PubMed:39321809). The gTuRC regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments, a critical step in centrosome duplication and spindle formation (PubMed:39321809)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
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        "total_reported_o_glycosites": 1,
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        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3SWV8;Q8WVB2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005813 centrosome;GO:0005819 spindle;GO:0005829 cytosol;GO:0000931 gamma-tubulin ring complex",
        "go_biological_process": "GO:0007020 microtubule nucleation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q6P582-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15522-1",
        "uniprot_id": [
            {
                "id": "NKX28_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15522",
                "type": "external"
            }
        ],
        "mass": 25866.0,
        "length": 239,
        "protein_name": "Homeobox protein Nkx-2.8",
        "gene_name": "NKX2-8",
        "organism": "Human",
        "refseq_name": "homeobox protein Nkx-2.8",
        "refseq_ac": [
            {
                "id": "NP_055175",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055175",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NKX2-8; NKX-2.8; NKX2G; NKX2H",
        "gene_names_refseq": "NKX2-8; NKX2.8; NKX2H; Nkx2-9",
        "protein_names_uniprotkb": "Homeobox protein Nkx-2.8; Homeobox protein NK-2 homolog H",
        "protein_names_refseq": "NK-2 homolog 8; NK2 transcription factor related, locus 8; homeobox protein NK-2 homolog H; homeobox protein Nkx-2.8",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:26257)",
        "pathway_count": 1,
        "publication_count": 6,
        "publication_id_list": "12167706;29242379;29311157;31047858;35610207;9446603",
        "class_list": "",
        "function": "A murine Nkx2.8 was isolated from the Hepal-6 cell line and showed oligonucleotide binding competitive with fetoprotein transcription factor., [RefSeq, PubMed]; Low NKX2-8 expression is associated with Bladder Urothelial Carcinoma., [RefSeq, PubMed]; Nkx2.8 promotes chemosensitivity in bladder urothelial carcinoma via transcriptional repression of MDR1. Publication Status: Online-Only, [RefSeq, PubMed]; Our results demonstrate that NKX2-8 deletion-reprogrammed FA metabolism contributes to chemoresistance and Perhexiline might serve as a potential tailored treatment for patients with NKX2-8-deleted EOC., [RefSeq, PubMed]; The protein encoded by this gene is a homeobox-containing developmental regulator associated with liver development. The encoded protein binds to the alpha-fetoprotein (AFP) gene promoter and increases the expression of AFP. This gene is overexpressed in some lung cancers and is linked to poor patient survival, possibly due to its resistance to cisplatin. This gene is aberrantly methylated in pancreatic cancer, deleted in squamous cell lung carcinomas, and acts as a tumor suppressor in esophageal cancer. Mutations in this gene may also be a cause of neural tube defects. [provided by RefSeq, Dec 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IUT7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0003690 double-stranded DNA binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0001889 liver development;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation;GO:0045944 positive regulation of transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 0.7,
        "record_id": "O15522-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43677-1",
        "uniprot_id": [
            {
                "id": "NDUC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43677",
                "type": "external"
            }
        ],
        "mass": 8734.0,
        "length": 76,
        "protein_name": "NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial",
        "gene_name": "NDUFC1",
        "organism": "Human",
        "refseq_name": "NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor",
        "refseq_ac": [
            {
                "id": "NP_001171915",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171915",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NDUFC1",
        "gene_names_refseq": "KFYI; NDUFC1",
        "protein_names_uniprotkb": "NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial; CI-KFYI; Complex I-KFYI; NADH-ubiquinone oxidoreductase KFYI subunit",
        "protein_names_refseq": "CI-KFYI; NADH dehydrogenase (ubiquinone) 1, subcomplex unknown, 1, 6kDa; NADH dehydrogenase [ubiquinone] 1 subunit C1, mitochondrial precursor; NADH-ubiquinone oxidoreductase KFYI subunit; complex I KFYI subunit; complex I-KFYI",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4717);  (R-HSA-611105);  (R-HSA-6799198)",
        "pathway_count": 3,
        "publication_count": 54,
        "publication_id_list": "10327278;11220739;11237011;11695836;12231006;12837546;1327877;14741580;15250827;16230336;17033964;17936786;186667;19752196;20406883;20552642;20858599;21924235;23150584;23270816;23553477;23564345;23747254;239860;24191001;24715725;25564869;25576301;25678554;26992070;27499296;27626371;28904123;31611695;31666358;31866046;32265295;32320651;32502341;32938616;33141586;33298915;33879611;33882309;34171305;35333655;35614220;36241641;38199007;4288886;9425316;9571201;9653160;9878551",
        "class_list": "",
        "function": "Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The encoded protein is a subunit of the NADH:ubiquinone oxidoreductase (complex I), the first enzyme complex in the electron transport chain located in the inner mitochondrial membrane. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K532;Q3MIJ9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008137 NADH dehydrogenase (ubiquinone) activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005743 mitochondrial inner membrane;GO:0045271 respiratory chain complex I",
        "go_biological_process": "GO:0006120 mitochondrial electron transport, NADH to ubiquinone;GO:0042776 proton motive force-driven mitochondrial ATP synthesis;GO:0009060 aerobic respiration;GO:0022904 respiratory electron transport chain",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "O43677-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O60287-1",
        "uniprot_id": [
            {
                "id": "NPA1P_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O60287",
                "type": "external"
            }
        ],
        "mass": 254389.0,
        "length": 2271,
        "protein_name": "Nucleolar pre-ribosomal-associated protein 1",
        "gene_name": "URB1",
        "organism": "Human",
        "refseq_name": "nucleolar pre-ribosomal-associated protein 1",
        "refseq_ac": [
            {
                "id": "NP_055640",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055640",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "URB1; C21orf108; KIAA0539; NOP254; NPA1",
        "gene_names_refseq": "C21orf108; NPA1; URB1",
        "protein_names_uniprotkb": "Nucleolar pre-ribosomal-associated protein 1; Nucleolar protein 254 kDa; URB1 ribosome biogenesis 1 homolog",
        "protein_names_refseq": "URB1 ribosome biogenesis 1 homolog; URB1 ribosome biogenesis homolog; nucleolar pre-ribosomal-associated protein 1; nucleolar preribosomal-associated protein 1; nucleolar protein 254 kDa",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9875)",
        "pathway_count": 1,
        "publication_count": 114,
        "publication_id_list": "10773462;12429849;16963496;20068231;20220067;21209280;22424782;22544926;22645359;22898188;23481700;24029068;24714562;24715725;25418920;25576301;25645385;25802875;25892735;26154972;26375851;26728094;26811146;26929215;26992070;27397612;27600516;27846572;27862975;27893789;27920218;28063628;28218747;28228285;28514659;28832583;28834231;28855257;28904123;29237092;29242379;29331515;29371260;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30410026;30429286;30484775;30524438;30779550;30833945;31092671;31154438;31217245;31222486;31530632;31844290;31848261;31886628;31937595;31998317;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32888357;32897882;32938616;32983136;33091337;33141586;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34405274;34509645;34561969;34931806;34932366;35051231;35561310;35580925;35661819;36010968;36215666;36241641;36284347;36581221;37938771;39894887;40596516",
        "class_list": "",
        "function": "RAPTOR promotes colorectal cancer proliferation by inducing mTORC1 and upregulating ribosome assembly factor URB1. Erratum:[Cancer Med. 2021 Oct;10(20):7442-7443. doi: 10.1002/cam4.4337. PMID: 34608772], [RefSeq, PubMed]; Ribosome assembly factor URB1 contributes to colorectal cancer proliferation through transcriptional activation of ATF4., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
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        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DSE5;Q96NX1;Q9NYQ1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0001650 fibrillar center",
        "go_biological_process": "GO:0000463 maturation of LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA);GO:0000466 maturation of 5.8S rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "O60287-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C0P6-1",
        "uniprot_id": [
            {
                "id": "NPS_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C0P6",
                "type": "external"
            }
        ],
        "mass": 10103.0,
        "length": 89,
        "protein_name": "Neuropeptide S",
        "gene_name": "NPS",
        "organism": "Human",
        "refseq_name": "neuropeptide S precursor",
        "refseq_ac": [
            {
                "id": "NP_001025184",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025184",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NPS",
        "gene_names_refseq": "NPS",
        "protein_names_uniprotkb": "Neuropeptide S",
        "protein_names_refseq": "neuropeptide S precursor; prepro-neuropeptide S",
        "tax_id": 9606,
        "disease": "morphine dependence (Disease Ontology:DOID:2560)",
        "pathway": " (hsa:594857);  (R-HSA-375276);  (R-HSA-416476);  (R-HSA-418555)",
        "pathway_count": 4,
        "publication_count": 175,
        "publication_id_list": "10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10899166;11007482;11015615;11322507;11385580;11457843;11562423;11683476;11742120;11753430;11773063;12036966;12058044;12106601;12120503;12180353;12427552;12540846;12719537;1280419;12860470;12956774;1314587;1317848;1325670;1337145;1346068;13549488;14463577;14550283;14573733;14671004;15139756;1517224;15312648;15539556;1567413;15765929;15769620;15947423;15951850;16182515;16268778;16313925;16339447;1655761;16687412;16720571;16754659;16790440;16923326;1710450;1710578;17168849;1719979;1722333;18044684;18127230;18434541;1847994;18515384;18577758;18936096;1905813;19105585;19876791;19929708;20381629;21036126;2163110;23446738;23690594;2417744;24687066;24906252;2491850;2553411;2553705;25714705;26417854;2649896;26865629;27496565;2841328;28463995;2871555;29443750;29602314;30833991;3086311;3127824;31279028;31326375;31399091;31983287;3202875;32226383;32497535;32540603;32618402;32715661;33049737;33556445;3366244;34252586;3525564;38287231;3856870;6085243;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8340388;8373420;8381365;8383682;8395824;8440682;8463333;8503909;8514797;8615752;8664309;8666380;8672451;8702752;873923;8823230;9171878;9263355;9305846;9417641;9521323;9530155;9593744;9607765;9651336;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "Analgesic effects of NPS are linked with dopaminergic neurotransmission mainly through dopamine D2-like receptor signaling, [RefSeq, PubMed]; Further refining the critical region of 10q26 microdeletion syndrome: A possible involvement of INSYN2 and NPS in the cognitive phenotype., [RefSeq, PubMed]; Ligand for NPSR1 (PubMed:15312648, PubMed:15947423, PubMed:16720571, PubMed:16790440). Binds to its receptor with nanomolar affinity and initiates a G(q)/GNAQ-dependent phospholipase C-activating signaling pathway. This results in Ca(2+) mobilization from intracellular stores and increased intracellular Ca(2+) levels (PubMed:15312648, PubMed:15947423, PubMed:16720571, PubMed:16790440, PubMed:25714705, PubMed:26865629). In addition to this pathway, NPS binding to its receptor activates cAMP/PKA signal transduction (PubMed:26865629). Finally, both pathways converge to activate ERK1/ERK2 phosphorylation and signaling cascade (PubMed:26865629). Modulates arousal and anxiety. May play an important anorexigenic role (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Neandertal introgression and accumulation of hypomorphic mutations in the neuropeptide S (NPS) system promote attenuated functionality., [RefSeq, PubMed]; SNPs modify asthma risk Publication Status: Online-Only, [RefSeq, PubMed]; Sphingosine 1-phosphate signaling axis mediates neuropeptide S-induced invasive phenotype of endometriotic cells., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_mutagensis": 6,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0160041 neuropeptide activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0007218 neuropeptide signaling pathway;GO:0070374 positive regulation of ERK1 and ERK2 cascade;GO:0032230 positive regulation of synaptic transmission, GABAergic;GO:0051968 positive regulation of synaptic transmission, glutamatergic;GO:0007200 phospholipase C-activating G protein-coupled receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 17.6,
        "record_id": "P0C0P6-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P12036-1",
        "uniprot_id": [
            {
                "id": "NFH_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P12036",
                "type": "external"
            }
        ],
        "mass": 111838.0,
        "length": 1020,
        "protein_name": "Neurofilament heavy polypeptide",
        "gene_name": "NEFH",
        "organism": "Human",
        "refseq_name": "neurofilament heavy polypeptide",
        "refseq_ac": [
            {
                "id": "NP_066554",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066554",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NEFH; KIAA0845; NFH",
        "gene_names_refseq": "CMT2CC; NEFH; NFH",
        "protein_names_uniprotkb": "Neurofilament heavy polypeptide; 200 kDa neurofilament protein; NF-H; Neurofilament triplet H protein",
        "protein_names_refseq": "200 kDa neurofilament protein; NF-H; neurofilament heavy polypeptide; neurofilament triplet H protein; neurofilament, heavy polypeptide 200kDa",
        "tax_id": 9606,
        "disease": "autoimmune optic neuritis (Disease Ontology:DOID:0040089); congenital hypothyroidism (Disease Ontology:DOID:0050328); amyotrophic lateral sclerosis type 1 (Disease Ontology:DOID:0060193); Charcot-Marie-Tooth disease axonal type 2CC (Disease Ontology:DOID:0110180); sciatic neuropathy (Disease Ontology:DOID:11446); Creutzfeldt-Jakob disease (Disease Ontology:DOID:11949); optic neuritis (Disease Ontology:DOID:1210); hypothyroidism (Disease Ontology:DOID:1459); glaucoma (Disease Ontology:DOID:1686); status epilepticus (Disease Ontology:DOID:1824); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); relapsing-remitting multiple sclerosis (Disease Ontology:DOID:2378); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); monoclonal gammopathy of uncertain significance (Disease Ontology:DOID:7442); epilepsy with generalized tonic-clonic seizures (Disease Ontology:DOID:7725); neuromyelitis optica (Disease Ontology:DOID:8869); phenylketonuria (Disease Ontology:DOID:9281)",
        "pathway": " (hsa:4744)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "12130654;18510355;24275569;27040688;28657654;28832583;29242379;29786170;30379171;30397120;31092671;3138108;32161166;33895854;34518334;35091664;36042248;36200879;7849698;8621664;9592082",
        "class_list": "",
        "function": "An NEFH founder mutation causes broad phenotypic spectrum in multiple Japanese families., [RefSeq, PubMed]; Charcot-Marie-Tooth disease type 2CC due to NEFH variants causes a progressive, non-length-dependent, motor-predominant phenotype., [RefSeq, PubMed]; Intronic NEFH variant is associated with reduced risk for sporadic ALS and later age of disease onset. Publication Status: Online-Only, [RefSeq, PubMed]; Myelin basic protein and neurofilament H in postmortem cerebrospinal fluid as surrogate markers of fatal traumatic brain injury., [RefSeq, PubMed]; Neurodegeneration Markers in the Cerebrospinal Fluid of 100 Patients with Schizophrenia Spectrum Disorder., [RefSeq, PubMed]; Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the heavy neurofilament protein. This protein is commonly used as a biomarker of neuronal damage and susceptibility to amyotrophic lateral sclerosis (ALS) has been associated with mutations in this gene. [provided by RefSeq, Oct 2008]., [RefSeq]; Neurofilaments usually contain three intermediate filament proteins: NEFL, NEFM, and NEFH which are involved in the maintenance of neuronal caliber. NEFH has an important function in mature axons that is not subserved by the two smaller NF proteins. May additionally cooperate with the neuronal intermediate filament proteins PRPH and INA to form neuronal filamentous networks (By similarity)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 10,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 10,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 10,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 48,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 18,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DYY4;Q96HF8;Q9UJS7;Q9UQ14",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0008017 microtubule binding;GO:0019901 protein kinase binding;GO:0030674 protein-macromolecule adaptor activity;GO:0019894 kinesin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0014069 postsynaptic density;GO:0030424 axon;GO:0005883 neurofilament",
        "go_biological_process": "GO:0045110 intermediate filament bundle assembly;GO:0007409 axonogenesis;GO:0061564 axon development;GO:0030031 cell projection assembly;GO:0033693 neurofilament bundle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "P12036-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P17050-1",
        "uniprot_id": [
            {
                "id": "NAGAB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P17050",
                "type": "external"
            }
        ],
        "mass": 46565.0,
        "length": 411,
        "protein_name": "Alpha-N-acetylgalactosaminidase",
        "gene_name": "NAGA",
        "organism": "Human",
        "refseq_name": "alpha-N-acetylgalactosaminidase precursor",
        "refseq_ac": [
            {
                "id": "NP_000253",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000253",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAGA",
        "gene_names_refseq": "D22S674; GALB; NAGA",
        "protein_names_uniprotkb": "Alpha-N-acetylgalactosaminidase; 3.2.1.49; Alpha-galactosidase B",
        "protein_names_refseq": "Acetylgalactosaminidase, alpha-N- (alpha-galactosidase B); N-acetylgalactosaminidase, alpha-; alpha-N-acetylgalactosaminidase precursor; alpha-NaGalase; nagalase",
        "tax_id": 9606,
        "disease": "Schindler disease type 1 (Disease Ontology:DOID:0112318); Kanzaki disease (Disease Ontology:DOID:0112319); Fabry disease (Disease Ontology:DOID:14499); neuroaxonal dystrophy (Disease Ontology:DOID:2367); angiokeratoma (Disease Ontology:DOID:479); obsolete Schindler disease (MONDO:MONDO:0000189)",
        "pathway": " (hsa:4668)",
        "pathway_count": 1,
        "publication_count": 62,
        "publication_id_list": "10.1101/2023.09.13.557529;10704524;11251574;11313741;1418679;1646157;17693683;19159218;19683538;2174888;2243144;22544926;2256909;23090970;23481700;2372288;24190977;24715725;25502872;2551294;25576301;2564952;26853435;27862975;27920218;28228285;28467828;28832583;28904123;29242379;29557506;29741879;30315122;31154438;31468281;31844290;32157095;32350084;32357974;32387766;32938616;32983136;33043033;33141586;33298915;33931730;33968037;34357683;34509645;34816536;35008409;35051231;35154160;35521802;35580925;37074911;38665916;7707696;8040340;8071745;8782044;9741689",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "A Novel Homozygous Missense Variant in the NAGA Gene with Extreme Intrafamilial Phenotypic Heterogeneity., [RefSeq, PubMed]; A missense variant in NDUFA6 confers schizophrenia risk by affecting YY1 binding and NAGA expression., [RefSeq, PubMed]; Could low alpha-N-acetylgalactosaminidase plasma concentration cause schizophrenia?, [RefSeq, PubMed]; NAGA encodes the lysosomal enzyme alpha-N-acetylgalactosaminidase, which cleaves alpha-N-acetylgalactosaminyl moieties from glycoconjugates. Mutations in NAGA have been identified as the cause of  Schindler disease types I and II (type II also known as Kanzaki disease). [provided by RefSeq, Jul 2008]., [RefSeq]; Removes terminal alpha-N-acetylgalactosamine residues from glycolipids and glycopeptides. Required for the breakdown of glycolipids., [UniProtKB, PubMed]; Silencing of alpha-N-acetylgalactosaminidase in the gastric cancer cells amplified cell death and attenuated migration, while the multidrug resistance remained unchanged., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 5,
        "mined_n_glycosites": 5,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 6,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 6,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 30,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 530,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 95,
        "disease_count": 6,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [
            {
                "id": "3.2.1.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.49",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0004557 alpha-galactosidase activity;GO:0008456 alpha-N-acetylgalactosaminidase activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0016020 membrane;GO:0070062 extracellular exosome;GO:0005764 lysosome",
        "go_biological_process": "GO:0019377 glycolipid catabolic process;GO:0016052 carbohydrate catabolic process;GO:0009311 oligosaccharide metabolic process;GO:0016139 glycoside catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 16.5,
        "record_id": "P17050-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100100000001.110.10100",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P47972-1",
        "uniprot_id": [
            {
                "id": "NPTX2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P47972",
                "type": "external"
            }
        ],
        "mass": 47042.0,
        "length": 431,
        "protein_name": "Neuronal pentraxin-2",
        "gene_name": "NPTX2",
        "organism": "Human",
        "refseq_name": "neuronal pentraxin-2 precursor",
        "refseq_ac": [
            {
                "id": "NP_002514",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002514",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NPTX2",
        "gene_names_refseq": "NARP; NP-II; NP2; NPTX2",
        "protein_names_uniprotkb": "Neuronal pentraxin-2; NP-II; NP2; Neuronal pentraxin II",
        "protein_names_refseq": "apexin; neuronal activity-regulated pentaxin; neuronal pentraxin II; neuronal pentraxin-2 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4885)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10.1101/2023.09.13.557529;10748068;16115696;17408830;23090970;24190977;27543614;29393594;29557506;31154438;31844290;33633747;34087483;35051231;36010968;36120776;36284347;36638907;37074911;37345460;37614206;38355792;8530029",
        "class_list": "",
        "function": "A Combination of Neurofilament Light, Glial Fibrillary Acidic Protein, and Neuronal Pentraxin-2 Discriminates Between Frontotemporal Dementia and Other Dementias., [RefSeq, PubMed]; A model of human neural networks reveals NPTX2 pathology in ALS and FTLD., [RefSeq, PubMed]; Assessments of the Utilities of CSF NPTX2 for Disease Progression in Cognitively Normal Individuals Who Progress to Clinical MCI and AD., [RefSeq, PubMed]; Likely to play role in the modification of cellular properties that underlie long-term plasticity. Binds to agar matrix in a calcium-dependent manner (By similarity)., [UniProtKB]; NPTX2 Promotes Epithelial-Mesenchymal Transition in Cutaneous Squamous Cell Carcinoma through METTL3-Mediated N6-Methyladenosine Methylation of SNAIL., [RefSeq, PubMed]; NPTX2 in Cerebrospinal Fluid Predicts the Progression From Normal Cognition to Mild Cognitive Impairment., [RefSeq, PubMed]; Study tested for the association of four SNPs of NPTX2 & haplotypes consisting of the SNPs with autism, between autistic patients & controls in a Japanese population; no significant difference was observed in allele, genotype or haplotype frequencies GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The purpose of the present study was to assess the toxic effect of taipoxin in SCLC-cell lines and to determine if toxicity correlates to NPR and NP1 and NP2 expression levels., [RefSeq, PubMed]; This gene encodes a member of the family of neuronal petraxins, synaptic proteins that are related to C-reactive protein. This protein is involved in excitatory synapse formation. It also plays a role in clustering of alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptors at established synapses, resulting in non-apoptotic cell death of dopaminergic nerve cells. Up-regulation of this gene in Parkinson disease (PD) tissues suggests that the protein may be involved in the pathology of PD. [provided by RefSeq, Feb 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 29,
        "reported_interactions": 0,
        "missing_score": 9641,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D267;Q86XV7;Q96G70",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0030246 carbohydrate binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0098793 presynapse",
        "go_biological_process": "GO:0007268 chemical synaptic transmission",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "P47972-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P59044-1",
        "uniprot_id": [
            {
                "id": "NLRP6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P59044",
                "type": "external"
            }
        ],
        "mass": 98768.0,
        "length": 892,
        "protein_name": "NACHT, LRR and PYD domains-containing protein 6",
        "gene_name": "NLRP6",
        "organism": "Human",
        "refseq_name": "NACHT, LRR and PYD domains-containing protein 6 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001263629",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263629",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NLRP6; NALP6; PYPAF5",
        "gene_names_refseq": "AVR; CLR11.4; NALP6; NAVR/AVR; NAVR; NLRP6; PAN3; PYPAF5",
        "protein_names_uniprotkb": "NACHT, LRR and PYD domains-containing protein 6; Angiotensin II/vasopressin receptor; PYRIN-containing APAF1-like protein 5",
        "protein_names_refseq": "NACHT, LRR and PYD domains-containing protein 6 isoform 2; NACHT, LRR and PYD domains-containing protein 6; NACHT, leucine rich repeat and PYD containing 6; PYRIN-containing APAF1-like protein 5; angiotensin II/vasopressin receptor; nucleotide-binding oligomerization domain, leucine rich repeat and pyrin domain containing 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:171389)",
        "pathway_count": 1,
        "publication_count": 31,
        "publication_id_list": "11984003;12019269;12387869;12563287;21088234;21593405;23470617;24714562;26154972;26282398;29493099;30392956;30674671;31154438;31530632;31844290;31848261;31932628;32387766;33141586;33377178;34161762;34678144;35051231;35651286;37770465;38278335;38315242;38720893;7489366;9095083",
        "class_list": "",
        "function": "A novel pyroptosis risk model composed of NLRP6 effectively predicts the prognosis of hepatocellular carcinoma patients., [RefSeq, PubMed]; Acts as the sensor component of the NLRP6 inflammasome, which mediates inflammasome activation in response to various pathogen-associated signals, leading to maturation and secretion of IL1B and IL18 (PubMed:30392956, PubMed:34678144). Inflammasomes are supramolecular complexes that assemble in the cytosol in response to pathogens and other damage-associated signals and play critical roles in innate immunity and inflammation (PubMed:30674671). Acts as a recognition receptor (PRR): recognizes and binds specific pathogens and other damage-associated signals, such as lipoteichoic acid (LTA), a cell-wall component of Gram-positive bacteria, or double stranded RNA (dsRNA) (PubMed:30392956, PubMed:33377178, PubMed:34678144). May also recognize and bind lipopolysaccharide (LPS), a major component of the outer membrane of Gram-negative bacteria; however, LPS is probably not a major activator of the NLRP6 inflammasome (PubMed:31932628, PubMed:34678144). Following LTA- or dsRNA-binding, NLRP6 undergoes liquid-liquid phase separation (LLPS), enhancing multivalent interactions, an essential step for the formation of the NLRP6 inflammasome polymeric complex (PubMed:34678144). The NLRP6 inflammasome acts by promoting recruitment of effector pro-inflammatory caspases (CASP1 and/or CASP4) that catalyze maturation and secretion of IL1B and IL18 in the extracellular milieu (PubMed:12387869, PubMed:30392956, PubMed:30674671, PubMed:34678144). The NLRP6 inflammasome plays a central role in the maintenance of epithelial integrity and host defense against microbial infections in the intestine (PubMed:30392956). Required to restrict infection against Gram-positive bacteria by recognizing lipoteichoic acid (LTA), leading to recruitment of CASP4 and CASP1, and subsequent maturation and secretion of IL1B and IL18 (PubMed:30392956, PubMed:33377178). Involved in intestinal antiviral innate immunity together with DHX15: recognizes and binds viral dsRNA to restrict infection by enteric viruses through the interferon pathway and GSDMD-dependent release of IL18 (PubMed:34161762, PubMed:34678144). Required to prevent infection by the apicomplexan parasite Cryptosporidium in enterocytes by promoting GSDMD-dependent release of IL18 (By similarity). The NLRP6 inflammasome may also regulate the gut microbiota composition by acting as a sensor of microbiota-associated metabolites to form a PYCARD/ASC-dependent inflammasome for downstream IL18 release and secretion of antimicrobial peptides (By similarity). Essential for gut mucosal self-renewal and proliferation (By similarity). Regulate mucus secretion in an inflammasome- and autophagy-dependent manner to prevent invasion by enteric bacteria, (By similarity). During systemic bacterial infections, the NLRP6 inflammasome negatively regulates neutrophil recruitment and neutrophil extracellular traps (NETs) formation (By similarity). May promote peripheral nerve recovery following injury via an inflammasome-independent mechanism (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Decreased expression of the NLRP6 inflammasome is associated with increased intestinal permeability and inflammation in obesity with type 2 diabetes. Publication Status: Online-Only, [RefSeq, PubMed]; NLRP6 deficiency suppresses colorectal cancer liver metastasis growth by modulating M-MDSC-induced immunosuppressive microenvironment., [RefSeq, PubMed]; NLRP6 negatively regulates host defense against polymicrobial sepsis. Publication Status: Online-Only, [RefSeq, PubMed]; NLRP6 potentiates PI3K/AKT signalling by promoting autophagic degradation of p85alpha to drive tumorigenesis. Publication Status: Online-Only, [RefSeq, PubMed]; The dual AngII/AVP receptor gene N119S/C163R variant exhibits sodium-induced dysfunction and cosegregates with salt-sensitive hypertension in the Dahl salt-sensitive hypertensive rat model., [RefSeq, PubMed]; The protein encoded by this gene binds arginine-vasopressin and may be involved in the arginine-vasopressin-mediated regulation of renal salt-water balance. The encoded protein also mediates inflammatory responses in the colon to allow recovery from intestinal epithelial damage and protects against tumorigenesis and the development of colitis. Finally, this protein can increase activation of NF-kappa-B, activation of CASP1 through interaction with ASC, and cAMP accumulation. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]., [RefSeq]; This publication deals with the rat ortholog of the human NLRP6 gene., [RefSeq, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9F3;E9PJZ8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0003725 double-stranded RNA binding;GO:0042277 peptide binding;GO:0035591 signaling adaptor activity;GO:0001530 lipopolysaccharide binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0031965 nuclear membrane;GO:0061702 canonical inflammasome complex",
        "go_biological_process": "GO:0050830 defense response to Gram-positive bacterium;GO:0051260 protein homooligomerization;GO:0051607 defense response to virus;GO:0002862 negative regulation of inflammatory response to antigenic stimulus;GO:0043124 negative regulation of canonical NF-kappaB signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 3.2,
        "record_id": "P59044-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15223-1",
        "uniprot_id": [
            {
                "id": "NECT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15223",
                "type": "external"
            }
        ],
        "mass": 57158.0,
        "length": 517,
        "protein_name": "Nectin-1",
        "gene_name": "NECTIN1",
        "organism": "Human",
        "refseq_name": "nectin-1 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_002846",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002846",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NECTIN1; HVEC; PRR1; PVRL1",
        "gene_names_refseq": "CD111; CLPED1; ED4; HIgR; HV1S; HVEC; NECTIN1; OFC7; PRR1; PRR; PVRL1; PVRR1; PVRR; SK-12; nectin-1",
        "protein_names_uniprotkb": "Nectin-1; HIgR; Herpes virus entry mediator C; Herpesvirus Ig-like receptor; Herpesvirus entry mediator C; HveC; Nectin cell adhesion molecule 1; Poliovirus receptor-related protein 1",
        "protein_names_refseq": "ectodermal dysplasia 4 (Margarita Island type); herpes simplex virus type 1 sensitivity; herpes virus entry mediator C; herpesvirus Ig-like receptor; nectin 1; nectin-1 isoform 1 precursor; poliovirus receptor-like 1; poliovirus receptor-related 1 (herpesvirus entry mediator C); poliovirus receptor-related protein 1",
        "tax_id": 9606,
        "disease": "cleft lip-palate-ectodermal dysplasia syndrome (Disease Ontology:DOID:0060773); ectodermal dysplasia (Disease Ontology:DOID:2121); cleft palate (Disease Ontology:DOID:674); cleft lip (Disease Ontology:DOID:9296)",
        "pathway": " (hsa:5818);  (R-HSA-418990);  (R-HSA-420597)",
        "pathway_count": 3,
        "publication_count": 90,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10225955;10932188;11237011;11356977;11544254;11559849;12050160;12759359;15741237;16335952;16467305;16679515;17016520;17967169;18510355;19139490;19349973;19354288;19901323;21325282;21406692;21980294;22146396;22902367;23090970;23555621;23584533;24190977;24715725;25231300;25372031;25502872;25576301;25913853;26992070;28218747;28228285;28381567;28542478;28832583;28834231;28904123;29242379;29314611;29393594;29437277;29632046;29741879;30192525;30429286;30459171;30779550;31844290;31848261;31998317;32157095;32938616;33141586;33298915;33537174;33592498;33717175;33936100;33968037;34019948;34357683;34587223;35051231;35154160;35580925;35705054;36010968;36229674;37074911;37289055;38471041;38857290;39048823;39048830;39139080;40307207;7721102;7806582;9219219;9616127;9657005;9696799;9845526",
        "class_list": "",
        "function": "(Microbial infection) Acts as a receptor for herpes simplex virus 1/HHV-1, herpes simplex virus 2/HHV-2, and pseudorabies virus/PRV (PubMed:21980294, PubMed:25231300, PubMed:28381567, PubMed:28542478, PubMed:34587223, PubMed:38857290, PubMed:39048823, PubMed:39048830, PubMed:7721102, PubMed:9616127, PubMed:9657005). Constitutes the major receptor for herpes simplex virus 1/HHV-1 entry into host cells (PubMed:34587223)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Cell adhesion molecule that promotes cell-cell contacts and plays important roles in the development of the nervous system (PubMed:21325282). Acts by forming homophilic or heterophilic trans-dimers (PubMed:21325282). Heterophilic interactions have been detected between NECTIN1 and NECTIN3 and between NECTIN1 and NECTIN4 (By similarity). Involved in axon guidance by promoting contacts between the commissural axons and the floor plate cells (By similarity). Involved in synaptogegesis (By similarity). Has some neurite outgrowth-promoting activity (By similarity). Promotes formation of checkerboard-like cellular pattern of hair cells and supporting cells in the auditory epithelium via heterophilic interaction with NECTIN3: NECTIN1 is present in the membrane of hair cells and associates with NECTIN3 on supporting cells, thereby mediating heterotypic adhesion between these two cell types (By similarity). Required for enamel mineralization (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; Downregulation of endogenous nectin1 in human keratinocytes by herpes simplex virus 1 glycoprotein D excludes superinfection but does not affect NK cell function., [RefSeq, PubMed]; Ex Vivo Infection of Human Skin Models with Herpes Simplex Virus 1: Accessibility of the Receptor Nectin-1 during Formation or Impairment of Epidermal Barriers Is Restricted by Tight Junctions., [RefSeq, PubMed]; Genetic associations and parent-of-origin effects of PVRL1 in non-syndromic cleft lip with or without cleft palate across multiple ethnic populations., [RefSeq, PubMed]; Loss of NECTIN1 triggers melanoma dissemination upon local IGF1 depletion., [RefSeq, PubMed]; This gene encodes an adhesion protein that plays a role in the organization of adherens junctions and tight junctions in epithelial and endothelial cells. The protein is a calcium(2+)-independent cell-cell adhesion molecule that belongs to the immunoglobulin superfamily and has 3 extracellular immunoglobulin-like loops, a single transmembrane domain (in some isoforms), and a cytoplasmic region. This protein acts as a receptor for glycoprotein D (gD) of herpes simplex viruses 1 and 2 (HSV-1, HSV-2), and pseudorabies virus (PRV) and mediates viral entry into epithelial and neuronal cells. Mutations in this gene cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 8,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 6,
        "reported_mutagensis": 17,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 17,
        "disease_count": 4,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75465;Q2M3D3;Q9HBE6;Q9HBW2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0015026 coreceptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0050839 cell adhesion molecule binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0032584 growth cone membrane;GO:0048787 presynaptic active zone membrane;GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0005912 adherens junction",
        "go_biological_process": "GO:0006955 immune response;GO:0007155 cell adhesion;GO:0098609 cell-cell adhesion;GO:0046718 symbiont entry into host cell;GO:0051963 regulation of synapse assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 11.9,
        "record_id": "Q15223-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15818-1",
        "uniprot_id": [
            {
                "id": "NPTX1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15818",
                "type": "external"
            }
        ],
        "mass": 47122.0,
        "length": 432,
        "protein_name": "Neuronal pentraxin-1",
        "gene_name": "NPTX1",
        "organism": "Human",
        "refseq_name": "neuronal pentraxin-1 precursor",
        "refseq_ac": [
            {
                "id": "NP_002513",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002513",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NPTX1",
        "gene_names_refseq": "NP1; NPTX1; SCA50",
        "protein_names_uniprotkb": "Neuronal pentraxin-1; NP-I; NP1; Neuronal pentraxin I",
        "protein_names_refseq": "NP-I; neuronal pentraxin I; neuronal pentraxin-1 precursor",
        "tax_id": 9606,
        "disease": "autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441); spinocerebellar ataxia 50 (MONDO:MONDO:0859334)",
        "pathway": " (hsa:4884)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;16115696;17151277;20068231;23090970;24190977;25029423;29242379;29557506;30484775;32502341;32855309;34171305;34212686;34788392;35051231;35216489;35285082;35560436;37357360;37515330;8884281",
        "class_list": "",
        "function": "Downregulation of NPTX1 induces cell cycle progression through Wnt/beta-catenin signaling in breast cancer., [RefSeq, PubMed]; Long acting progestin contraceptive-enhanced NPTX1 secretion and reactive oxygen species generation in endometrial stromal cells impair endometrial endothelial cells survival resulting in a loss in vascular integrity., [RefSeq, PubMed]; May be involved in mediating uptake of synaptic material during synapse remodeling or in mediating the synaptic clustering of AMPA glutamate receptors at a subset of excitatory synapses., [UniProtKB, UniProtKB]; MiR-148a-3p regulates proliferation and apoptosis of idiopathic gingival fibroma by targeting NPTX1., [RefSeq, PubMed]; NPTX1 is a member of the neuronal pentraxin gene family. Neuronal pentraxin 1 is similar to the rat NP1 gene which encodes a binding protein for the snake venom toxin taipoxin. Human NPTX1 mRNA is exclusively localized to the nervous system. [provided by RefSeq, Jul 2008]., [RefSeq]; NPTX1 mutations trigger endoplasmic reticulum stress and cause autosomal dominant cerebellar ataxia., [RefSeq, PubMed]; Neuronal pentraxin 1 transgene is a key factor for the synapse loss, the neurite damage, and the apoptotic neuronal death evoked by amyloid-beta protein, which regulates NP1 expression., [RefSeq, PubMed]; Proteomic analysis of the human hippocampus identifies neuronal pentraxin 1 (NPTX1) as synapto-axonal target in late-stage Parkinson's disease., [RefSeq, PubMed]; The purpose of the present study was to assess the toxic effect of taipoxin in SCLC-cell lines and to determine if toxicity correlates to NPR and NP1 and NP2 expression levels., [RefSeq, PubMed]; Tryptophan Metabolites Regulate Neuropentraxin 1 Expression in Endothelial Cells. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KXH3;Q5FWE6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005783 endoplasmic reticulum;GO:0043083 synaptic cleft;GO:0030133 transport vesicle;GO:0005576 extracellular region",
        "go_biological_process": "GO:0097107 postsynaptic density assembly;GO:0006839 mitochondrial transport;GO:0071333 cellular response to glucose stimulus;GO:0007268 chemical synaptic transmission;GO:0007417 central nervous system development",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q15818-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86UR1-1",
        "uniprot_id": [
            {
                "id": "NOXA1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86UR1",
                "type": "external"
            }
        ],
        "mass": 50933.0,
        "length": 476,
        "protein_name": "NADPH oxidase activator 1",
        "gene_name": "NOXA1",
        "organism": "Human",
        "refseq_name": "NADPH oxidase activator 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001242996",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001242996",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NOXA1; P51NOX",
        "gene_names_refseq": "NOXA1; NY-CO-31; SDCCAG31; p51NOX",
        "protein_names_uniprotkb": "NADPH oxidase activator 1; Antigen NY-CO-31; NCF2-like protein; NOX activator 1; P67phox-like factor; p51-nox",
        "protein_names_refseq": "NADPH oxidase activator 1 isoform 2; NCF2-like protein; Nox activator 1; antigen NY-CO-31; inhibitory NADPH oxidase activator 1; p51-nox; p67phox-like factor; serologically defined colon cancer antigen 31",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10811);  (R-HSA-5668599);  (R-HSA-9013149);  (R-HSA-9013423);  (R-HSA-9673324)",
        "pathway_count": 5,
        "publication_count": 296,
        "publication_id_list": "10072071;10232922;10400704;10455184;10464238;10490598;10508610;10523665;10523675;10526156;10559246;10579713;10618392;10698942;10699171;10699464;10871633;10873802;10958683;11007481;11058585;11085924;11090627;11101902;11145705;11149925;11237011;11358862;11373293;11396949;11431473;11432776;11584276;11672528;11704860;11707441;11751577;11756552;11773441;11779461;11803464;11804587;11804589;11804590;11884391;11912491;11956649;11961559;12015986;12056906;12071859;12093360;12096337;12097334;12195014;12221096;12351724;12432077;12531887;12533515;12546821;12547822;12650940;12657628;12665586;12716910;12857875;12877655;12923183;14512443;14514689;14530365;14617635;14636582;1464587;14675773;14718541;14978110;15023524;15033976;15064355;15107133;15133129;15143170;15147912;15181005;15302923;15339924;15342493;15485661;15507211;15579468;15591124;15601624;15608632;15611138;15728722;15824103;15850391;15858067;15897194;15936275;16002401;16112081;16116428;16184169;16243036;16329988;16473593;16492808;16507994;16519628;1660188;16636067;16702231;16762923;16777452;16777849;16778989;16862148;16896804;16914516;16968698;17077126;17126813;17130287;17145773;17196961;17214551;17244649;17583407;17599059;17602954;17627283;17702745;17765681;17804252;17913709;17976533;18006505;18045877;18218625;18249095;18347018;18396277;18426980;18653540;18697831;18719708;18793328;18838382;19269969;19365405;19372727;19494238;19534724;19605563;19673492;19713215;19755710;19934221;20006983;20110267;20230789;20400958;20457807;20460433;20609497;20679435;20810653;20813901;20943948;20956805;21148482;21239714;21542010;21565175;21613211;21730051;21865595;21989057;22004470;22096251;22298643;22407364;22475431;22608513;22734669;22808130;22970203;23109420;23209303;23255595;23288169;23289851;23396967;23434736;23572525;23707487;23718289;23821037;23875749;23940355;23980663;24086303;24259668;24335996;24352656;24859002;24865425;24933155;24960694;25024229;25211221;25428919;25704760;25721503;25795300;25862245;25877926;26129894;26529257;26628301;26887924;26992070;27117132;27145964;27216196;27481945;27555588;27558335;27566826;27713499;27806292;28114311;28196833;28218747;28356423;28834231;29089502;29358323;29382922;29437277;30853411;31871319;32015503;32094511;32203420;32847975;35051231;35580925;7479768;7512369;7559638;7673236;7721814;7753201;7835339;8021274;8089108;8107774;8537347;8543060;8643598;8645157;8662891;8756646;8769096;8798539;8805223;8810315;8816443;8939998;8947551;8990121;8994827;9013646;9099726;9113980;9252344;9305890;9438849;9490638;9497316;9520479;9582072;9610721;9659915;9670022;9674432;9716412;9792683;9804763;9822598;9843499;9988689",
        "class_list": "",
        "function": "Functions as an activator of NOX1, a superoxide-producing NADPH oxidase. Functions in the production of reactive oxygen species (ROS) which participate in a variety of biological processes including host defense, hormone biosynthesis, oxygen sensing and signal transduction. May also activate CYBB/gp91phox and NOX3., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; MARCH5 requires MTCH2 to coordinate proteasomal turnover of the MCL1:NOXA complex., [RefSeq, PubMed]; MARCH5-dependent degradation of MCL1/NOXA complexes defines susceptibility to antimitotic drug treatment., [RefSeq, PubMed]; The Novel Histone Deacetylase Inhibitor, OBP-801, Induces Apoptosis in Rhabdoid Tumors by Releasing the Silencing of NOXA., [RefSeq, PubMed]; This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Dec 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 12,
        "reported_mutagensis": 10,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60533;Q29VU9;Q29VV0;Q2TAM1;Q8IUS3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0017124 SH3 domain binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0031267 small GTPase binding;GO:0016176 superoxide-generating NADPH oxidase activator activity",
        "go_cellular_component": "GO:0043020 NADPH oxidase complex;GO:0005829 cytosol",
        "go_biological_process": "GO:0006801 superoxide metabolic process;GO:0042554 superoxide anion generation;GO:0010310 regulation of hydrogen peroxide metabolic process;GO:0060263 regulation of respiratory burst",
        "synthesized_glycan_count": 0,
        "hit_score": 29.7,
        "record_id": "Q86UR1-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BT67-1",
        "uniprot_id": [
            {
                "id": "NFIP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BT67",
                "type": "external"
            }
        ],
        "mass": 24899.0,
        "length": 221,
        "protein_name": "NEDD4 family-interacting protein 1",
        "gene_name": "NDFIP1",
        "organism": "Human",
        "refseq_name": "NEDD4 family-interacting protein 1",
        "refseq_ac": [
            {
                "id": "NP_085048",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085048",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NDFIP1; N4WBP5; PSEC0192; PSEC0223",
        "gene_names_refseq": "N4WBP5; NDFIP1",
        "protein_names_uniprotkb": "NEDD4 family-interacting protein 1; Breast cancer-associated protein SGA-1M; NEDD4 WW domain-binding protein 5; Putative MAPK-activating protein PM13; Putative NF-kappa-B-activating protein 164; Putative NFKB and MAPK-activating protein",
        "protein_names_refseq": "NEDD4 family-interacting protein 1; Nedd4 WW domain-binding protein 5; breast cancer-associated protein SGA-1M; putative MAPK-activating protein PM13; putative NF-kappa-B-activating protein 164; putative NFKB and MAPK-activating protein",
        "tax_id": 9606,
        "disease": "stroke (Disease Ontology:DOID:0051061)",
        "pathway": " (hsa:80762)",
        "pathway_count": 1,
        "publication_count": 79,
        "publication_id_list": "11748237;12761501;16303743;18776082;18819914;19343052;19706893;20068231;20112406;20534535;21081667;22223895;23087404;23328677;25418920;25469497;25502872;25576301;25631046;25632008;25645385;25801959;26154972;26319551;26363003;26811146;26929215;26992070;27452731;27846572;27920218;28063628;28218747;28467828;28855257;29242379;29314611;29317506;29393594;29493099;29557506;29632046;29632711;29786170;30315122;30429286;31092671;31154438;31844290;31848261;32157095;32161166;32162841;32265295;32357974;32387766;32488085;32897882;32983136;33043033;33091337;33392160;33592498;33912179;33936100;33968037;34171305;34320783;34357683;34433824;34725369;34932366;35051231;35154160;35580925;36215666;36617825;36929005;38365133",
        "class_list": "",
        "function": "Activates HECT domain-containing E3 ubiquitin-protein ligases, including NEDD4 and ITCH, and consequently modulates the stability of their targets. As a result, controls many cellular processes. Prevents chronic T-helper cell-mediated inflammation by activating ITCH and thus controlling JUNB degradation (By similarity). Promotes pancreatic beta cell death through degradation of JUNB and inhibition of the unfolded protein response, leading to reduction of insulin secretion (PubMed:26319551). Restricts the production of pro-inflammatory cytokines in effector Th17 T-cells by promoting ITCH-mediated ubiquitination and degradation of RORC (By similarity). Together with NDFIP2, limits the cytokine signaling and expansion of effector Th2 T-cells by promoting degradation of JAK1, probably by ITCH- and NEDD4L-mediated ubiquitination (By similarity). Regulates peripheral T-cell tolerance to self and foreign antigens, forcing the exit of naive CD4+ T-cells from the cell cycle before they become effector T-cells (By similarity). Negatively regulates RLR-mediated antiviral response by promoting SMURF1-mediated ubiquitination and subsequent degradation of MAVS (PubMed:23087404). Negatively regulates KCNH2 potassium channel activity by decreasing its cell-surface expression and interfering with channel maturation through recruitment of NEDD4L to the Golgi apparatus where it mediates KCNH2 degradation (PubMed:26363003). In cortical neurons, mediates the ubiquitination of the divalent metal transporter SLC11A2/DMT1 by NEDD4L, leading to its down-regulation and protection of the cells from cobalt and iron toxicity (PubMed:19706893). Important for normal development of dendrites and dendritic spines in cortex (By similarity). Enhances the ubiquitination of BRAT1 mediated by: NEDD4, NEDD4L and ITCH and is required for the nuclear localization of ubiquitinated BRAT1 (PubMed:25631046). Enhances the ITCH-mediated ubiquitination of MAP3K7 by recruiting E2 ubiquitin-conjugating enzyme UBE2L3 to ITCH (By similarity). Modulates EGFR signaling through multiple pathways. In particular, may regulate the ratio of AKT1-to-MAPK8 signaling in response to EGF, acting on AKT1 probably through PTEN destabilization and on MAPK8 through ITCH-dependent MAP2K4 inactivation. As a result, may control cell growth rate (PubMed:20534535). Inhibits cell proliferation by promoting PTEN nuclear localization and changing its signaling specificity (PubMed:25801959)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Genetic variation in NDFIP1 modifies the metabolic patterns in immune cells of multiple sclerosis patients. Publication Status: Online-Only, [RefSeq, PubMed]; NDFIP1 limits cellular TAZ accumulation via exosomal sorting to inhibit NSCLC proliferation., [RefSeq, PubMed]; Ndfip1 is required for the exosomal secretion of Nedd4 family proteins, [RefSeq, PubMed]; Ndfip1 protected dopaminergic neurons via regulating mitochondrial function and ferroptosis in Parkinson's disease., [RefSeq, PubMed]; Research progress on the role of Ndfip1 (Nedd4 family interacting protein 1) in immune cells. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene belongs to a small group of evolutionarily conserved proteins with three transmembrane domains. It is a potential target for ubiquitination by the Nedd4 family of proteins. This protein is thought to be part of a family of integral Golgi membrane proteins. [provided by RefSeq, Jul 2008]., [RefSeq]; UBA6 and NDFIP1 regulate the degradation of ferroportin. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RDB8;D3DQF0;Q658T8;Q8N2E3;Q8N2F9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0050699 WW domain binding",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005938 cell cortex",
        "go_biological_process": "GO:0007034 vacuolar transport;GO:0006879 intracellular iron ion homeostasis;GO:0043123 positive regulation of canonical NF-kappaB signal transduction;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0031398 positive regulation of protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 8.0,
        "record_id": "Q9BT67-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H009-1",
        "uniprot_id": [
            {
                "id": "NACA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H009",
                "type": "external"
            }
        ],
        "mass": 23223.0,
        "length": 215,
        "protein_name": "Nascent polypeptide-associated complex subunit alpha-2",
        "gene_name": "NACA2",
        "organism": "Human",
        "refseq_name": "nascent polypeptide-associated complex subunit alpha-2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_954984",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_954984",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NACA2; NACAL",
        "gene_names_refseq": "ANAC; NACA2; NACAL",
        "protein_names_uniprotkb": "Nascent polypeptide-associated complex subunit alpha-2; Alpha-NAC-like; Hom s 2.01; NAC-alpha-like; Nascent polypeptide-associated complex subunit alpha-like",
        "protein_names_refseq": "IgE autoantigen alpha-nascent polypeptide-associated complex; alpha-NAC protein; hom s 2.01 protein; nascent polypeptide associated complex alpha subunit 2; nascent polypeptide-associated complex subunit alpha-2 isoform 1; nascent polypeptide-associated complex, alpha polypeptide, 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:342538)",
        "pathway_count": 1,
        "publication_count": 30,
        "publication_id_list": "12406326;16201836;19690332;20546612;22645359;23657466;26024233;26154972;26962231;26992070;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29331515;29393594;29786170;29789417;30192525;30315122;30524438;33298915;33592498;33633747;33936100;34087483;37217939",
        "class_list": "",
        "function": "Alpha-nac is a potent inducer of a Th1 response via IL12 and TLR2., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Prevents inappropriate targeting of non-secretory polypeptides to the endoplasmic reticulum (ER). Binds to nascent polypeptide chains as they emerge from the ribosome and blocks their interaction with the signal recognition particle (SRP), which normally targets nascent secretory peptides to the ER. Also reduces the inherent affinity of ribosomes for protein translocation sites in the ER membrane (M sites) (By similarity)., [UniProtKB]",
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        "predicted_n_glycosites": 0,
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        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
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        "reported_snv": 10,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2VIR9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051082 unfolded protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005854 nascent polypeptide-associated complex",
        "go_biological_process": "GO:0015031 protein transport;GO:0006612 protein targeting to membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q9H009-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9ULW6-1",
        "uniprot_id": [
            {
                "id": "NP1L2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9ULW6",
                "type": "external"
            }
        ],
        "mass": 52542.0,
        "length": 460,
        "protein_name": "Nucleosome assembly protein 1-like 2",
        "gene_name": "NAP1L2",
        "organism": "Human",
        "refseq_name": "nucleosome assembly protein 1-like 2",
        "refseq_ac": [
            {
                "id": "NP_068798",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_068798",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NAP1L2; BPX",
        "gene_names_refseq": "BPX; NAP1L2",
        "protein_names_uniprotkb": "Nucleosome assembly protein 1-like 2; Brain-specific protein, X-linked; Histone chaperone NAP1L2",
        "protein_names_refseq": "brain specific gene BPX; brain-specific protein, X-linked; histone chaperone NAP1L2; nucleosome assembly protein 1-like 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4674)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "21333655;23481700;26967585;28228285;29493099;29508533;30315122;30429286;31844290;31848261;32938616;32983136;33091337;35032339;35051231;35251023;37217939",
        "class_list": "",
        "function": "Histone chaperone (By similarity). Plays a role in the epigenetic regulation of gene expression during cellular differentiation, by regulating the acetylation status of histone H3 and therefore chromatin accessibility (PubMed:35032339). Plays a role in the differentiation of neuronal cells (By similarity). Increased activity during aging may suppress osteogenic differentiation of bone marrow mesenchymal stem cells (BMSCs) and promote their senescence; recruits SIRT1 to deacetylate histone H3 'Lys-14' at the promoter of osteogenic genes (PubMed:35032339)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; NAP1L2 may play an important role in the development and progression of atopic dermatitis., [RefSeq, PubMed]; Results identified several proteins interacting with NAP1L2, including the ubiquitously expressed members of the nucleosome assembly protein family, NAP1L1 and NAP1L4., [RefSeq, PubMed]; The protein encoded by this intronless gene is a member of the nucleosome assembly protein (NAP) family. The encoded protein represents a class of tissue-specific factors that interact with chromatin to regulate neuronal cell proliferation. [provided by RefSeq, Jan 2011]., [RefSeq]",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RE61;B4E161;Q8TAN6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0042393 histone binding;GO:0035034 histone acetyltransferase regulator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0000785 chromatin",
        "go_biological_process": "GO:0030182 neuron differentiation;GO:0006334 nucleosome assembly;GO:0040029 epigenetic regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q9ULW6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A087X179-1",
        "uniprot_id": [
            {
                "id": "TBC3E_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A087X179",
                "type": "external"
            }
        ],
        "mass": 62131.0,
        "length": 549,
        "protein_name": "TBC1 domain family member 3E",
        "gene_name": "TBC1D3E",
        "organism": "Human",
        "refseq_name": "TBC1 domain family member 3E",
        "refseq_ac": [
            {
                "id": "NP_001278395",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278395",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TBC1D3E",
        "gene_names_refseq": "PRC17; TBC1D3E",
        "protein_names_uniprotkb": "TBC1 domain family member 3E",
        "protein_names_refseq": "Prostate cancer gene 17 protein; Protein TRE17-alpha; Rab GTPase-activating protein PRC17; TBC1 domain family member 3E; TBC1 domain family member 3; TBC1 domain family member-like",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:102723859)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "16863688;21030649",
        "class_list": "",
        "function": "Acts as a GTPase activating protein for RAB5. Does not act on RAB4 or RAB11 (By similarity)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity",
        "go_cellular_component": "GO:0005768 endosome;GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "A0A087X179-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A1B0GTY4-1",
        "uniprot_id": [
            {
                "id": "TEX50_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A1B0GTY4",
                "type": "external"
            }
        ],
        "mass": 20847.0,
        "length": 177,
        "protein_name": "Testis-expressed protein 50",
        "gene_name": "TEX50",
        "organism": "Human",
        "refseq_name": "testis-expressed protein 50 precursor",
        "refseq_ac": [
            {
                "id": "NP_001182119",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001182119",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TEX50",
        "gene_names_refseq": "TEX50",
        "protein_names_uniprotkb": "Testis-expressed protein 50",
        "protein_names_refseq": "testis-expressed protein 50 precursor; testis-expressed protein 50",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:730159)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "35051231;36284347;40906813",
        "class_list": "",
        "function": "Sperm membrane protein required for stability of the sperm acrosome after its formation in the testis. Essential for male fertility., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "go_cellular_component": "GO:0016020 membrane",
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        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "A0A1B0GTY4-1",
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        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NHL2-1",
        "uniprot_id": [
            {
                "id": "TBAL3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NHL2",
                "type": "external"
            }
        ],
        "mass": 49909.0,
        "length": 446,
        "protein_name": "Tubulin alpha chain-like 3",
        "gene_name": "TUBAL3",
        "organism": "Human",
        "refseq_name": "tubulin alpha chain-like 3 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001165335",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001165335",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TUBAL3",
        "gene_names_refseq": "TUBAL3",
        "protein_names_uniprotkb": "Tubulin alpha chain-like 3; 3.6.5.-",
        "protein_names_refseq": "tubulin alpha chain-like 3 isoform 2; tubulin alpha chain-like 3",
        "tax_id": 9606,
        "disease": "lissencephaly (Disease Ontology:DOID:0050453); polymicrogyria (Disease Ontology:DOID:0080918); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234)",
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            {
                "id": "NP_001273587",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001273587",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TBC1D4; AS160; KIAA0603",
        "gene_names_refseq": "AS160; NIDDM5; TBC1D4",
        "protein_names_uniprotkb": "TBC1 domain family member 4; AS160; Akt substrate of 160 kDa",
        "protein_names_refseq": "TBC (Tre-2, BUB2, CDC16) domain-containing protein; TBC1 domain family member 4 isoform 2; akt substrate of 160 kDa",
        "tax_id": 9606,
        "disease": "acanthosis nigricans (Disease Ontology:DOID:3138); diabetes mellitus, noninsulin-dependent, 5 (MONDO:MONDO:0014488)",
        "pathway": " (hsa:9882);  (R-HSA-1445148)",
        "pathway_count": 2,
        "publication_count": 140,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11994271;12637568;15302935;15304337;15919790;15971998;16083285;16880201;16964243;17081983;17287340;17322306;17369524;17617058;17693683;17995453;18212344;18220336;18276765;18452278;18669648;18767875;18771725;18801932;19013499;19077034;19252894;19413330;19470471;19608861;19651622;19664994;19664995;19690332;19897488;20068231;20166139;20410134;20574165;20631154;20701589;20837646;20937701;20938636;21406692;21454505;21454690;21505451;21907143;22207758;22333157;22645359;22851577;22908308;23186163;23481700;23752133;23801578;24247980;24275569;24714562;24715725;24843827;24876356;25043022;25103239;25280670;25418920;2550440;25505266;25645385;25892735;25991826;26154972;26375851;26811146;27600516;27846572;27920218;28063628;28228285;28292969;28487439;28510447;28832583;28904123;29242379;29393594;29493099;29557506;29632046;29632711;29786170;30135087;30315122;30410026;30429286;30484775;30833945;30872638;31154438;31530632;31844290;31848261;32161166;32357974;32365859;32387766;32488085;32502341;32891058;32897882;32921413;32938616;32983136;33141586;33298915;33592498;33717175;33912179;33968037;33981976;34171305;34357683;34932366;35051231;35318648;35580925;36010968;36215666;36241641;36284347;36944026;37129117;39181362;40914422;8094051;8664345",
        "class_list": "",
        "function": "AS160 phosphotyrosine-binding domain constructs inhibit insulin-stimulated GLUT4 vesicle fusion with the plasma membrane, [RefSeq, PubMed]; Expression characteristics of TBC1D4 activating protein molecule and identification of key module genes for preventing thyroid cancer progression., [RefSeq, PubMed]; KIAA0603 is likely to be a Rab GAP that participates in the regulation of activated T cells in atopic dermatitis, [RefSeq, PubMed]; May act as a GTPase-activating protein for RAB2A, RAB8A, RAB10 and RAB14. Isoform 2 promotes insulin-induced glucose transporter SLC2A4/GLUT4 translocation at the plasma membrane, thus increasing glucose uptake., [UniProtKB, PubMed, PubMed, PubMed]; Prematurely truncated TBC1D4 protein tended to increase basal cell membrane GLUT4 levels (P = 0.053) and significantly reduced insulin-stimulated GLUT4 cell membrane translocation (P < 0.05)., [RefSeq, PubMed]; The effect of diabetes and the diabetogenic TBC1D4 p.Arg684ter variant on kidney function in Inuit in Greenland., [RefSeq, PubMed]; The effect of traditional diet on glucose homoeostasis in carriers and non-carriers of a common TBC1D4 variant in Greenlandic Inuit: a randomised crossover study., [RefSeq, PubMed]; The transcript variant 2 of AS160 in contrast to full-length AS160 is a novel regulator of glucose transport that positively influences glucose-uptake rates., [RefSeq, PubMed]; This gene is a member of the Tre-2/BUB2/CDC16 domain family. The protein encoded by this gene is a Rab-GTPase-activating protein, and contains two phopshotyrosine-binding domains (PTB1 and PTB2), a calmodulin-binding domain (CBD), a Rab-GTPase domain, and multiple AKT phosphomotifs. This protein is thought to play an important role in glucose homeostasis by regulating the insulin-dependent trafficking of the glucose transporter 4 (GLUT4), important for removing glucose from the bloodstream into skeletal muscle and fat tissues. Reduced expression of this gene results in an increase in GLUT4 levels at the plasma membrane, suggesting that this protein is important in intracellular retention of GLUT4 under basal conditions. When exposed to insulin, this protein is phosphorylated, dissociates from GLUT4 vesicles, resulting in increased GLUT4 at the cell surface, and enhanced glucose transport. Phosphorylation of this protein by AKT is required for proper translocation of GLUT4 to the cell surface. Individuals homozygous for a mutation in this gene are at higher risk for type 2 diabetes and have higher levels of circulating glucose and insulin levels after glucose ingestion. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 37,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 30,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7E2X8;B4DU25;B4E235;B6ETN8;B6ETN9;Q5W0B9;Q68D14",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005829 cytosol",
        "go_biological_process": "GO:0032869 cellular response to insulin stimulus;GO:0016192 vesicle-mediated transport",
        "synthesized_glycan_count": 0,
        "hit_score": 14.5,
        "record_id": "O60343-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75333-1",
        "uniprot_id": [
            {
                "id": "TBX10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75333",
                "type": "external"
            }
        ],
        "mass": 42341.0,
        "length": 385,
        "protein_name": "T-box transcription factor TBX10",
        "gene_name": "TBX10",
        "organism": "Human",
        "refseq_name": "T-box transcription factor TBX10",
        "refseq_ac": [
            {
                "id": "NP_005986",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005986",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TBX10; TBX7",
        "gene_names_refseq": "TBX10; TBX13; TBX7",
        "protein_names_uniprotkb": "T-box transcription factor TBX10; T-box protein 10",
        "protein_names_refseq": "T-box 10; T-box 7; T-box protein 10; T-box transcription factor TBX10; T-box-containing transcriptional activator",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:347853)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "12915323;16247549;16327884;20544801;20572854;28228285;28834231;29393594;9545502",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed, PubMed, PubMed]; Probable transcriptional regulator involved in developmental processes., [UniProtKB]; This gene encodes a member of the T-box family of transcription factors. These transcription factors share a DNA-binding domain called the T-box, and play a role in several developmental processes including early embryonic cell fate and organogenesis. The encoded protein is a member of the T-box 1 subfamily. Mutations in this gene are thought to be a cause of isolated cleft lip with or without cleft palate. [provided by RefSeq, Nov 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14D64;Q86XS3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0000785 chromatin",
        "go_biological_process": "GO:0001708 cell fate specification;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0009653 anatomical structure morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "O75333-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P05543-1",
        "uniprot_id": [
            {
                "id": "THBG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P05543",
                "type": "external"
            }
        ],
        "mass": 46325.0,
        "length": 415,
        "protein_name": "Thyroxine-binding globulin",
        "gene_name": "SERPINA7",
        "organism": "Human",
        "refseq_name": "thyroxine-binding globulin precursor",
        "refseq_ac": [
            {
                "id": "NP_000345",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000345",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SERPINA7; TBG",
        "gene_names_refseq": "SERPINA7; TBGQTL; TBG",
        "protein_names_uniprotkb": "Thyroxine-binding globulin; Serpin A7; T4-binding globulin",
        "protein_names_refseq": "T4-binding globulin; mutant serpin family A member 7; serine (or cysteine) proteinase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; serpin A7; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 7; thyroxin-binding globulin; thyroxine-binding globulin precursor; thyroxine-binding globulin",
        "tax_id": 9606,
        "disease": "hypothyroidism (Disease Ontology:DOID:1459); diabetic ketoacidosis (Disease Ontology:DOID:1837); hyperthyroidism (Disease Ontology:DOID:7998); diabetes mellitus (Disease Ontology:DOID:9351); type 1 diabetes mellitus (Disease Ontology:DOID:9744)",
        "pathway": " (hsa:6906)",
        "pathway_count": 1,
        "publication_count": 33,
        "publication_id_list": "1294376;1515456;16335952;16938877;18407078;1901689;1906047;19838169;2115061;2155256;23090970;2495303;2501669;29391424;29557506;29671580;29741879;30237853;30459171;3094014;32266677;32350084;33554479;34481533;34725484;34761328;35580925;36241641;36475360;37074911;414747;8232304;8268226",
        "class_list": "",
        "function": "Compound hemizygous variants in SERPINA7 gene cause thyroxine-binding globulin deficiency., [RefSeq, PubMed]; Identification of Mutations in the Thyroxine-Binding Globulin (TBG) Gene in Patients with TBG Deficiency in Korea., [RefSeq, PubMed]; Identification of a novel mutation in thyroxine-binding globulin (TBG) gene associated with TBG-deficiency and its effect on the thyroid function., [RefSeq, PubMed]; Major thyroid hormone transport protein in serum., [UniProtKB]; Partial thyroxine-binding globulin deficiency in a family with coding region mutations in the TBG gene., [RefSeq, PubMed]; The decrease of T3 / T4 is not hypothyroidism - a new mutation of Serpina7 gene results in partial thyroglobulin deficiency., [RefSeq, PubMed]; There are three proteins including thyroxine-binding globulin (TBG), transthyretin and albumin responsible for carrying the thyroid hormones thyroxine (T4) and 3,5,3'-triiodothyronine (T3) in the bloodstream. This gene encodes the major thyroid hormone transport protein, TBG, in serum. It belongs to the serpin family in genomics, but the protein has no inhibitory function like many other members of the serpin family. Mutations in this gene result in TGB deficiency, which has been classified as partial deficiency, complete deficiency, and excess, based on the level of serum TBG. Alternatively spliced transcript variants encoding different isoforms have been found, but the full-length nature of these variants has not been determined.[provided by RefSeq, Jun 2012]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 930,
        "biomarker_type": "",
        "glycan_count": 41,
        "disease_count": 5,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DUX1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0070327 thyroid hormone transport",
        "synthesized_glycan_count": 0,
        "hit_score": 7.9,
        "record_id": "P05543-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P20061-1",
        "uniprot_id": [
            {
                "id": "TCO1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P20061",
                "type": "external"
            }
        ],
        "mass": 48207.0,
        "length": 433,
        "protein_name": "Transcobalamin-1",
        "gene_name": "TCN1",
        "organism": "Human",
        "refseq_name": "transcobalamin-1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001053",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001053",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TCN1; TC1",
        "gene_names_refseq": "HC; TC-1; TC1; TCI; TCN1",
        "protein_names_uniprotkb": "Transcobalamin-1; HC; Haptocorrin; Protein R; TC I; TC-1; TCI; Transcobalamin I",
        "protein_names_refseq": "haptocorin; haptocorrin; protein R; transcobalamin I (vitamin B12 binding protein, R binder family); transcobalamin-1 precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6947);  (R-HSA-6798695);  (R-HSA-9758881);  (R-HSA-9758890)",
        "pathway_count": 4,
        "publication_count": 52,
        "publication_id_list": "10080186;10887099;12590260;14528014;14576052;15652495;16335952;16537422;16740002;17954916;17990953;18779389;19136951;20237569;20524213;21511966;22547309;22631584;22900303;22922874;23090970;23650620;23836931;23846701;24190977;27411955;27456980;27600516;2777761;29391424;29741879;29769354;30523278;30777892;31844290;32125861;32157095;33845046;33968037;34549663;35686504;37074911;37209861;37586352;3782074;4001945;759210;7768901;8692836;8706697;8710919;915005",
        "class_list": "",
        "function": "Binds vitamin B12 with femtomolar affinity and protects it from the acidic environment of the stomach., [UniProtKB]; Clinicopathological Analysis and Prognostic Assessment of TCN1 in Patients with Gastric Cancer., [RefSeq, PubMed]; Reference intervals and stability of haptocorrin and holotranscobalamin in Danish children and elderly. Erratum:[Clin Chim Acta. 2024 Jan 1;552:117648. doi: 10.1016/j.cca.2023.117648. PMID: 37978014], [RefSeq, PubMed]; TCN1 Deficiency Inhibits the Malignancy of Colorectal Cancer Cells by Regulating the ITGB4 Pathway., [RefSeq, PubMed]; TCN1 Expression Is Increased in Asthma., [RefSeq, PubMed]; This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This protein is a major constituent of secondary granules in neutrophils and facilitates the transport of cobalamin into cells. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 7,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 38,
        "reported_interactions": 0,
        "missing_score": 8657,
        "biomarker_type": "",
        "glycan_count": 11,
        "disease_count": 0,
        "glyco_site_count": 8,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KAC5;Q8WV77",
        "ec_number_list": [],
        "go_molecular_function": "GO:0031419 cobalamin binding;GO:0140355 cargo receptor ligand activity;GO:0140313 molecular sequestering activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0035580 specific granule lumen;GO:1904724 tertiary granule lumen",
        "go_biological_process": "GO:0015889 cobalamin transport;GO:0006824 cobalt ion transport",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "P20061-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P40227-1",
        "uniprot_id": [
            {
                "id": "TCPZ_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P40227",
                "type": "external"
            }
        ],
        "mass": 58024.0,
        "length": 531,
        "protein_name": "T-complex protein 1 subunit zeta",
        "gene_name": "CCT6A",
        "organism": "Human",
        "refseq_name": "T-complex protein 1 subunit zeta isoform b",
        "refseq_ac": [
            {
                "id": "NP_001009186",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001009186",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CCT6A; CCT6; CCTZ",
        "gene_names_refseq": "CCT-zeta-1; CCT-zeta; CCT6A; CCT6; Cctz; HTR3; MoDP-2; TCP-1-zeta; TCP20; TCPZ; TTCP20",
        "protein_names_uniprotkb": "T-complex protein 1 subunit zeta; 3.6.1.-; Acute morphine dependence-related protein 2; CCT-zeta-1; Chaperonin containing T-complex polypeptide 1 subunit 6A; HTR3; TCP-1-zeta; Tcp20",
        "protein_names_refseq": "T-complex protein 1 subunit zeta isoform b; T-complex protein 1 subunit zeta; T-complex protein 1, zeta subunit; acute morphine dependence related protein 2; amino acid transport defect-complementing; chaperonin containing T-complex polypeptide 1 subunit 6A; chaperonin containing T-complex subunit 6; chaperonin containing TCP1, subunit 6A (zeta 1); histidine transport regulator 3",
        "tax_id": 9606,
        "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)",
        "pathway": " (hsa:908);  (R-HSA-389957);  (R-HSA-389960);  (R-HSA-390450);  (R-HSA-390471);  (R-HSA-6814122);  (R-HSA-9013418)",
        "pathway_count": 7,
        "publication_count": 155,
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        "class_list": "",
        "function": "CCT6A facilitates lung adenocarcinoma progression and glycolysis via STAT1/HK2 axis. Publication Status: Online-Only, [RefSeq, PubMed]; CCT6A knockdown suppresses osteosarcoma cell growth and Akt pathway activation in vitro. Publication Status: Online-Only, [RefSeq, PubMed]; CCT6A promotes cell proliferation in colon cancer by targeting BIRC5 associated with p53 status., [RefSeq, PubMed]; CCT6A promotes esophageal squamous cell carcinoma cell proliferation, invasion and epithelial-mesenchymal transition by activating TGF-beta/Smad/c-Myc pathway., [RefSeq, PubMed]; Chaperonin containing TCP1 subunit 6A may activate Notch and Wnt pathways to facilitate the malignant behaviors and cancer stemness in oral squamous cell carcinoma., [RefSeq, PubMed]; Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis (PubMed:25467444, PubMed:36493755, PubMed:35449234, PubMed:37193829). The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance (PubMed:25467444)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, several pseudogenes of this gene have been located. [provided by RefSeq, Jun 2010]., [RefSeq]",
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        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0044183 protein folding chaperone",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005874 microtubule;GO:0070062 extracellular exosome;GO:0005832 chaperonin-containing T-complex",
        "go_biological_process": "GO:1904871 positive regulation of protein localization to Cajal body;GO:0032212 positive regulation of telomere maintenance via telomerase;GO:0050821 protein stabilization;GO:0006457 protein folding;GO:1904851 positive regulation of establishment of protein localization to telomere",
        "synthesized_glycan_count": 0,
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        "record_id": "P40227-1",
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        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "TCTA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P57738",
                "type": "external"
            }
        ],
        "mass": 11341.0,
        "length": 103,
        "protein_name": "T-cell leukemia translocation-altered gene protein",
        "gene_name": "TCTA",
        "organism": "Human",
        "refseq_name": "T-cell leukemia translocation-altered gene protein",
        "refseq_ac": [
            {
                "id": "NP_071503",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071503",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TCTA",
        "gene_names_refseq": "TCTA",
        "protein_names_uniprotkb": "T-cell leukemia translocation-altered gene protein; T-cell leukemia translocation-associated gene protein",
        "protein_names_refseq": "T-cell leukemia translocation-altered gene protein; T-cell leukemia translocation-associated gene protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6988)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "19560569;19692168;19913121;20046013;20628086;22174563;28832583;29393594;29557506;30429286;31844290;31848261;32157095;7728759",
        "class_list": "",
        "function": "It expressed in synovial tissues from patients with RA and inhibits human osteoclastogenesis. (review) Review article, [RefSeq, PubMed]; May be required for cellular fusion during osteoclastogenesis., [UniProtKB, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; TCTA is a novel protein expressed in synovial tissues of rheumatoid arthritis that regulate human osteoclastogenesis., [RefSeq, PubMed]; TCTA protein has roles in lung cancer cell lines and human osteoclastogenesis [review] Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
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        "secondary_ac_list": "B2R4I4;Q6I9U4;Q9BSB0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "GO:0045671 negative regulation of osteoclast differentiation;GO:0072675 osteoclast fusion",
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    },
    {
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                "id": "TCAL1_HUMAN",
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            }
        ],
        "mass": 18641.0,
        "length": 159,
        "protein_name": "Transcription elongation factor A protein-like 1",
        "gene_name": "TCEAL1",
        "organism": "Human",
        "refseq_name": "transcription elongation factor A protein-like 1",
        "refseq_ac": [
            {
                "id": "NP_001006640",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006640",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TCEAL1; SIIR",
        "gene_names_refseq": "HIJRS; NEDGFAX; SIIR; TCEAL1; WEX9; p21; pp21",
        "protein_names_uniprotkb": "Transcription elongation factor A protein-like 1; Nuclear phosphoprotein p21/SIIR; TCEA-like protein 1; Transcription elongation factor S-II protein-like 1",
        "protein_names_refseq": "TCEA-like protein 1; nuclear phosphoprotein p21/SIIR; transcription elongation factor A (SII)-like 1; transcription elongation factor A protein-like 1; transcription elongation factor S-II protein-like 1",
        "tax_id": 9606,
        "disease": "neurodevelopmental disorder with gait disturbance, dysmorphic facies, and behavioral abnormalities, X-linked (MONDO:MONDO:0859085)",
        "pathway": " (hsa:9338)",
        "pathway_count": 1,
        "publication_count": 12,
        "publication_id_list": "10051408;17081983;17287340;19475409;19651622;20068231;31154438;33033111;36368327;38200082;7592688;8206389",
        "class_list": "",
        "function": "Confirmation and expansion of the phenotype of the TCEAL1-related neurodevelopmental disorder., [RefSeq, PubMed]; In vivo CRISPR/Cas9 knockout screen: TCEAL1 silencing enhances docetaxel efficacy in prostate cancer. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in transcriptional regulation. Modulates various viral and cellular promoters in a promoter context-dependent manner. For example, transcription from the FOS promoter is increased, while Rous sarcoma virus (RSV) long terminal repeat (LTR) promoter activity is repressed. Does not bind DNA directly., [UniProtKB]; TCEAL1 loss-of-function results in an X-linked dominant neurodevelopmental syndrome and drives the neurological disease trait in Xq22.2 deletions., [RefSeq, PubMed]; This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. Members of this family may function as nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. The encoded protein is similar to transcription elongation factor A/transcription factor SII and contains a zinc finger-like motif as well as a sequence related to the transcription factor SII Pol II-binding region. It may exert its effects via protein-protein interactions with other transcriptional regulators rather than via direct binding of DNA. Multiple family members are located on the X chromosome. Alternative splicing results in multiple transcript variants encoding a single isoform. [provided by RefSeq, Jul 2008]., [RefSeq]; Treatment with active matabolite of vitamin D (1alpha,25-dihydroxyvitamin D3) up-regulates mRNA expression of p21., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q9UJQ9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "Q15170-1",
        "record_type": "protein",
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    },
    {
        "uniprot_canonical_ac": "Q5T9Z0-1",
        "uniprot_id": [
            {
                "id": "TEDM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5T9Z0",
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        ],
        "mass": 31315.0,
        "length": 273,
        "protein_name": "Transmembrane epididymal protein 1",
        "gene_name": "TEDDM1",
        "organism": "Human",
        "refseq_name": "transmembrane epididymal protein 1",
        "refseq_ac": [
            {
                "id": "NP_741997",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_741997",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TEDDM1; HE9",
        "gene_names_refseq": "EDDM9; Epdd1; HE9; HEL-S-45e; TEDDM1; TMEM45C",
        "protein_names_uniprotkb": "Transmembrane epididymal protein 1; He9; Human epididymis-specific protein 9",
        "protein_names_refseq": "epididymal protein 9; epididymis secretory sperm binding protein Li 45e; human epididymis-specific protein 9; putative membrane protein HE9; transmembrane epididymal protein 1; transmembrane protein 45C",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:127670)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "31154438;32387766;34433824",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IVJ0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q5T9Z0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5H9L2-1",
        "uniprot_id": [
            {
                "id": "TCAL5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5H9L2",
                "type": "external"
            }
        ],
        "mass": 23307.0,
        "length": 206,
        "protein_name": "Transcription elongation factor A protein-like 5",
        "gene_name": "TCEAL5",
        "organism": "Human",
        "refseq_name": "transcription elongation factor A protein-like 5",
        "refseq_ac": [
            {
                "id": "NP_001012997",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012997",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TCEAL5",
        "gene_names_refseq": "TCEAL5; WEX4",
        "protein_names_uniprotkb": "Transcription elongation factor A protein-like 5; TCEA-like protein 5; Transcription elongation factor S-II protein-like 5",
        "protein_names_refseq": "TCEA-like protein 5; transcription elongation factor A (SII)-like 5; transcription elongation factor A protein-like 5; transcription elongation factor S-II protein-like 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:340543)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "20166139;36284347",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]; This gene, which is located on the X chromosome, encodes a protein which contains a BEX (brain expressed X-liked like family) domain. This domain is found in proteins encoded by the TCEAL elongation factor (transcription elongation factor A (SII)-like) gene family also located on the X chromosome. The coding region for this gene is located entirely in the terminal exon. [provided by RefSeq, Sep 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RUJ4",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q5H9L2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UBN4-1",
        "uniprot_id": [
            {
                "id": "TRPC4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UBN4",
                "type": "external"
            }
        ],
        "mass": 112101.0,
        "length": 977,
        "protein_name": "Short transient receptor potential channel 4",
        "gene_name": "TRPC4",
        "organism": "Human",
        "refseq_name": "short transient receptor potential channel 4 isoform beta",
        "refseq_ac": [
            {
                "id": "NP_001129427",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129427",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TRPC4",
        "gene_names_refseq": "HTRP-4; HTRP4; TRP4; TRPC4",
        "protein_names_uniprotkb": "Short transient receptor potential channel 4; Trp-related protein 4; TrpC4; hTrp-4; hTrp4",
        "protein_names_refseq": "short transient receptor potential channel 4 isoform beta; short transient receptor potential channel 4; trp-related protein 4",
        "tax_id": 9606,
        "disease": "nicotine dependence (Disease Ontology:DOID:0050742); autism spectrum disorder (Disease Ontology:DOID:0060041); neurodegenerative disease (Disease Ontology:DOID:1289); lung cancer (Disease Ontology:DOID:1324)",
        "pathway": " (hsa:7223);  (R-HSA-3295583);  (R-HSA-418890)",
        "pathway_count": 3,
        "publication_count": 39,
        "publication_id_list": "11042129;11050376;11163362;11226139;11243859;11301059;11713258;12015988;12032305;12154080;1422598;14634208;15757897;16144838;16254212;16959974;17081983;17850865;18048348;19996314;20025796;20164195;20574736;20716668;21427121;25389312;25765567;25855297;28124739;29351928;29557506;30429286;31324691;31848261;33968037;35051231;39009885;39478185;8646775",
        "class_list": "",
        "function": "Forms a receptor-activated non-selective calcium permeant cation channel (PubMed:11042129, PubMed:11713258, PubMed:16144838, PubMed:39478185). Acts as a cell-cell contact-dependent endothelial calcium entry channel (PubMed:19996314). Forms a homomeric ion channel or a heteromeric ion channel with TRPC1; the heteromeric ion channel has reduced calcium permeability compared to the homomeric channel (PubMed:39478185). Also permeable to monovalent ions including sodium, lithium and cesium ions (PubMed:39478185)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Forms a receptor-activated non-selective calcium permeant cation channel., [UniProtKB, PubMed]; In vitro and in vivo inhibition of the host TRPC4 channel attenuates Zika virus infection., [RefSeq, PubMed]; Results showed a trend toward association of TRPC4 variants and photoparoxysmal response/idiopathic generalized epilepsies. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a member of the canonical subfamily of transient receptor potential cation channels. The encoded protein forms a non-selective calcium-permeable cation channel that is activated by Gq-coupled receptors and tyrosine kinases, and plays a role in multiple processes including endothelial permeability, vasodilation, neurotransmitter release and cell proliferation. Single nucleotide polymorphisms in this gene may be associated with generalized epilepsy with photosensitivity. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1ALE0;B1ALE1;B1ALE2;Q15721;Q3SWS6;Q96P03;Q96P04;Q96P05;Q9UIB0;Q9UIB1;Q9UIB2",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "1.8.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0070679 inositol 1,4,5 trisphosphate binding;GO:0005262 calcium channel activity;GO:0045296 cadherin binding;GO:0008013 beta-catenin binding;GO:0005261 monoatomic cation channel activity",
        "go_cellular_component": "GO:0034703 cation channel complex;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0005901 caveola",
        "go_biological_process": "GO:0006816 calcium ion transport;GO:0051480 regulation of cytosolic calcium ion concentration;GO:0051899 membrane depolarization;GO:0070588 calcium ion transmembrane transport;GO:0003254 regulation of membrane depolarization",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q9UBN4-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P68543-1",
        "uniprot_id": [
            {
                "id": "UBX2A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P68543",
                "type": "external"
            }
        ],
        "mass": 29278.0,
        "length": 259,
        "protein_name": "UBX domain-containing protein 2A",
        "gene_name": "UBXN2A",
        "organism": "Human",
        "refseq_name": "UBX domain-containing protein 2A",
        "refseq_ac": [
            {
                "id": "NP_859064",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_859064",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UBXN2A; UBXD4",
        "gene_names_refseq": "UBXD4; UBXN2A",
        "protein_names_uniprotkb": "UBX domain-containing protein 2A; UBX domain-containing protein 4",
        "protein_names_refseq": "UBX domain containing 4; UBX domain-containing protein 2A; UBX domain-containing protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:165324)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "22454508;23481700;24366607;24625977;26154972;26265139;26634371;26992070;27600516;27920218;28218747;28832583;28904123;29393594;29437277;30315122;30410026;30429286;31217245;31844290;32157095;32161166;32357974;32387766;32502341;32938616;32983136;33141586;33298915;33936100;33968037;33981976;34087483;34171305;34509645;35580925;36010968;36241641;36889268;37037900",
        "class_list": "",
        "function": "Acts to repress the ubiquitination and subsequent endoplasmic reticulum-associated degradation of CHRNA3 by the STUB1-VCP-UBXN2A complex in cortical neurons (PubMed:26265139). Also acts to promote the translocation of CHRNA3 to the plasma membrane and subsequently increases plasma membrane acetylcholine-gated ion-channel activation (By similarity). Plays a role in the inhibition of STUB1-mediated TP53 degradation, via its interaction with HSPA9 which acts to inhibit TP53 binding to HSPA9 (PubMed:24625977, PubMed:26634371). Positively mediates the ubiquitination and proteosomal degradation of RICTOR, may thereby act as a negative regulator of the mTORC2 pathway (PubMed:37037900)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB]; UBXN2A suppresses the Rictor-mTORC2 signaling pathway, an established tumorigenic pathway in human colorectal cancer., [RefSeq, PubMed]; UBXN2A, a Ubiquitin-Like Protein, Alters Proteins in mTORC2 Pathway., [RefSeq, PubMed]; Ubx2 and Ubxd8 regulates lipid droplet homeostasis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "risk",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K577;B7ZKP8;Q569G8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0033130 acetylcholine receptor binding;GO:0043130 ubiquitin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005829 cytosol",
        "go_biological_process": "GO:0031468 nuclear membrane reassembly;GO:0000045 autophagosome assembly;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0045732 positive regulation of protein catabolic process;GO:0061025 membrane fusion",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "P68543-1",
        "record_type": "protein",
        "filter_code": "0000100.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6IBS0-1",
        "uniprot_id": [
            {
                "id": "TWF2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6IBS0",
                "type": "external"
            }
        ],
        "mass": 39548.0,
        "length": 349,
        "protein_name": "Twinfilin-2",
        "gene_name": "TWF2",
        "organism": "Human",
        "refseq_name": "twinfilin-2",
        "refseq_ac": [
            {
                "id": "NP_009215",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_009215",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TWF2; MSTP011; PTK9L",
        "gene_names_refseq": "A6RP; A6r; MSTP011; PTK9L; TWF2",
        "protein_names_uniprotkb": "Twinfilin-2; A6-related protein; Protein tyrosine kinase 9-like; Twinfilin-1-like protein; hA6RP",
        "protein_names_refseq": "PTK9L protein tyrosine kinase 9-like (A6-related protein); protein tyrosine kinase 9-like (A6-related protein); twinfilin, actin-binding protein, homolog 2; twinfilin-1-like protein; twinfilin-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:11344);  (R-HSA-9662360);  (R-HSA-9662361)",
        "pathway_count": 3,
        "publication_count": 66,
        "publication_id_list": "10025409;10406962;10821263;11163272;11230166;11237011;15592455;17344846;17910947;19608861;19690332;20166139;21406692;22424782;25505266;25576301;26154972;26375851;26992070;27726376;27846572;28832583;28904123;29242379;29351928;29493099;29557506;29632711;29786170;30315122;30429286;30779550;31154438;31530632;31844290;31848261;31998317;32157095;32162841;32350084;32387766;32488085;32502341;32938616;32983136;33043033;33298915;33592498;33912179;33968037;33981976;34019948;34357683;34725712;34932366;35051231;35132862;35154160;35251023;35580925;36241641;37055180;37938771;38665916;40596516;40914422",
        "class_list": "",
        "function": "Actin-binding protein involved in motile and morphological processes. Inhibits actin polymerization, likely by sequestering G-actin. By capping the barbed ends of filaments, it also regulates motility. Seems to play an important role in clathrin-mediated endocytosis and distribution of endocytic organelles. May play a role in regulating the mature length of the middle and short rows of stereocilia (By similarity)., [UniProtKB]; Cross-Platform Synaptic Network Analysis of Human Entorhinal Cortex Identifies TWF2 as a Modulator of Dendritic Spine Length., [RefSeq, PubMed]; The protein encoded by this gene was identified by its interaction with the catalytic domain of protein kinase C-zeta. The encoded protein contains an actin-binding site and an ATP-binding site. It is most closely related to twinfilin (PTK9), a conserved actin monomer-binding protein. [provided by RefSeq, Jul 2008]., [RefSeq]; Twinfilin-2 is a protein that is involved in neurite outgrowth, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9Y3F5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003785 actin monomer binding;GO:0005524 ATP binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005884 actin filament;GO:0030027 lamellipodium;GO:0030426 growth cone;GO:0048471 perinuclear region of cytoplasm",
        "go_biological_process": "GO:0010976 positive regulation of neuron projection development;GO:0032956 regulation of actin cytoskeleton organization;GO:0071300 cellular response to retinoic acid;GO:0051016 barbed-end actin filament capping;GO:0071363 cellular response to growth factor stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q6IBS0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6YHU6-1",
        "uniprot_id": [
            {
                "id": "THADA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6YHU6",
                "type": "external"
            }
        ],
        "mass": 219607.0,
        "length": 1953,
        "protein_name": "tRNA (32-2'-O)-methyltransferase regulator THADA",
        "gene_name": "THADA",
        "organism": "Human",
        "refseq_name": "tRNA (32-2'-O)-methyltransferase regulator THADA isoform a",
        "refseq_ac": [
            {
                "id": "NP_001077422",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077422",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "THADA; GITA; KIAA1767",
        "gene_names_refseq": "ARMC13; GITA; THADA; Trm732",
        "protein_names_uniprotkb": "tRNA (32-2'-O)-methyltransferase regulator THADA; Gene inducing thyroid adenomas protein; Thyroid adenoma-associated protein",
        "protein_names_refseq": "Trm732 homolog; death receptor-interacting protein; gene inducing thyroid adenomas protein; tRNA (32-2'-O)-methyltransferase regulator THADA isoform a; tRNA (32-2'-O)-methyltransferase regulator THADA; thyroid adenoma-associated protein",
        "tax_id": 9606,
        "disease": "non-syndromic X-linked intellectual disability (Disease Ontology:DOID:0050776); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:63892);  (R-HSA-6782315)",
        "pathway_count": 2,
        "publication_count": 113,
        "publication_id_list": "10430867;10982862;11027153;11111046;11237011;12403464;12955091;15861136;15870694;15994936;16043508;16424344;17071714;17123335;17889454;18372903;18567810;18567820;18691976;19017811;19414587;20068231;20123966;20308323;20354154;20584901;21059936;21131277;22344696;22424782;22591353;22995836;23042678;23048041;23186163;23381944;23481700;23604283;24029068;24126054;24204302;24715725;24901367;25261850;25404562;25418920;25576301;25645385;25880248;25892735;25916855;26154972;26160102;26310293;26375851;26811146;26992070;27055666;27600516;27846572;27862975;28904123;29437277;29557506;30410026;30429286;30484775;31092671;31217245;31481669;31844290;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33487086;33592498;33691108;33717175;33779462;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34405274;34509645;34561969;34932366;35051231;35254053;35494241;35580925;36010968;36215666;36241641;36610787;36672824;38561668;39894887;9430663;9851972",
        "class_list": "",
        "function": "Clinicopathologic Characteristics of Thyroid Nodules Positive for the THADA-IGF2BP3 Fusion on Preoperative Molecular Analysis., [RefSeq, PubMed]; Identification of the target gene of 2p21 aberrations in thyroid adenomas tentatively referred to as thyroid adenoma-associated gene (THADA); gene spans roughly 365 kbp; based on preliminary results, it encodes a death receptor-interacting protein [THADA], [RefSeq, PubMed]; Intronic sequence of PPAR(gamma) is fused to exon 28 of THADA in thyroid tumors of follicular origin including carcinomas as well as adenomas, [RefSeq, PubMed]; Meta-analysis and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Negative regulation of thyroid adenoma-associated protein (THADA) in the cardiac glycoside-induced anti-cancer effect. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Replication study of THADA rs13429458 variant with PCOS susceptibility and its related traits in Indian women., [RefSeq, PubMed]; THADA, SDHAF4, and MACF1 Gene Polymorphisms and Placental Expression in Women with Gestational Diabetes. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is the target of 2p21 choromosomal aberrations in benign thyroid adenomas. Single nucleotide polymorphisms (SNPs) in this gene may be associated with type 2 diabetes and polycystic ovary syndrome. The encoded protein is likely involved in the death receptor pathway and apoptosis. [provided by RefSeq, Sep 2016]., [RefSeq]; Together with methyltransferase FTSJ1, methylates the 2'-O-ribose of nucleotides at position 32 of the anticodon loop of substrate tRNAs., [UniProtKB, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "A8K1V8;B7WNS6;Q3KR04;Q53RC6;Q53TB2;Q6YHU2;Q6ZU38;Q8IY32;Q8TAU8;Q96I88;Q9BZF7;Q9C096;Q9H6U0;Q9H6W7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030234 enzyme regulator activity",
        "go_cellular_component": "GO:0098554 cytoplasmic side of endoplasmic reticulum membrane",
        "go_biological_process": "GO:0002128 tRNA nucleoside ribose methylation;GO:0055088 lipid homeostasis;GO:0030488 tRNA methylation;GO:0032471 negative regulation of endoplasmic reticulum calcium ion concentration;GO:1990845 adaptive thermogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 11.6,
        "record_id": "Q6YHU6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y4P3-1",
        "uniprot_id": [
            {
                "id": "TBL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y4P3",
                "type": "external"
            }
        ],
        "mass": 49798.0,
        "length": 447,
        "protein_name": "Transducin beta-like protein 2",
        "gene_name": "TBL2",
        "organism": "Human",
        "refseq_name": "transducin beta-like protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_036585",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_036585",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TBL2; PRO1125; WBSCR13",
        "gene_names_refseq": "TBL2; WBSCR13; WS-betaTRP",
        "protein_names_uniprotkb": "Transducin beta-like protein 2; WS beta-transducin repeats protein; WS-betaTRP; Williams-Beuren syndrome chromosomal region 13 protein",
        "protein_names_refseq": "WS beta-transducin repeats protein; Williams-Beuren syndrome chromosome region 13; epididymis secretory sperm binding protein; transducin -like 2; transducin beta-like protein 2 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26608)",
        "pathway_count": 1,
        "publication_count": 43,
        "publication_id_list": "10.1101/2023.09.13.557529;10575226;11230166;11237011;12975309;17525332;20068231;23481700;25418920;25576301;26154972;26239904;26992070;27846572;28510447;28904123;29437277;29485866;29493099;29557506;31154438;31530632;31844290;32157095;32357974;32387766;32502341;32811528;32938616;33298915;33592498;33633747;33912179;33968037;34019948;34229054;35051231;35580925;36241641;36284347;37477745;38665916;9860302",
        "class_list": "",
        "function": "TBL2 methylation is associated with hyper-low-density lipoprotein cholesterolemia: a case-control study. Publication Status: Online-Only, [RefSeq, PubMed]; TBL2 participates in ATF4 translation through its association with the mRNA., [RefSeq, PubMed]; This gene encodes a member of the beta-transducin protein family. Most proteins of the beta-transducin family are involved in regulatory functions. This protein is possibly involved in some intracellular signaling pathway. This gene is deleted in Williams-Beuren syndrome, a developmental disorder caused by deletion of multiple genes at 7q11.23. [provided by RefSeq, Jul 2008]., [RefSeq]; Transducin Beta-Like 2 is a Potential Driver Gene that Adapts to Endoplasmic Reticulum Stress to Promote Tumor Growth of Lung Adenocarcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q9UQE2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0019901 protein kinase binding;GO:0051219 phosphoprotein binding;GO:0031369 translation initiation factor binding",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0071456 cellular response to hypoxia;GO:0042149 cellular response to glucose starvation;GO:0030968 endoplasmic reticulum unfolded protein response",
        "synthesized_glycan_count": 0,
        "hit_score": 5.2,
        "record_id": "Q9Y4P3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UJT1-1",
        "uniprot_id": [
            {
                "id": "TBD_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UJT1",
                "type": "external"
            }
        ],
        "mass": 51034.0,
        "length": 453,
        "protein_name": "Tubulin delta chain",
        "gene_name": "TUBD1",
        "organism": "Human",
        "refseq_name": "tubulin delta chain isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001180538",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180538",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TUBD1; TUBD",
        "gene_names_refseq": "TUBD1; TUBD",
        "protein_names_uniprotkb": "Tubulin delta chain; Delta-tubulin",
        "protein_names_refseq": "delta-tubulin; tubulin delta chain isoform 2; tubulin delta chain",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51174)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "10620804;11237011;15081367;19913121;20628086;23481700;25576301;26768311;26992070;28832583;28834231;28904123;28906251;29242379;29493099;31844290;32157095;32357974;32387766;32897882;32938616;33968037;34087483;34561969;35580925",
        "class_list": "",
        "function": "Acts as a positive regulator of hedgehog signaling and regulates ciliary function., [UniProtKB, UniProtKB]; Here, the authors report that centrioles in delta-tubulin and epsilon-tubulin null mutant human cells lack triplet microtubules and fail to undergo centriole maturation. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "B4DPT8;B4DW01;D3DU02;E9PCA7;E9PCQ8;Q5KU36;Q9BWG9;Q9H7Z8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005200 structural constituent of cytoskeleton;GO:0005525 GTP binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005813 centrosome;GO:0005874 microtubule;GO:0005929 cilium",
        "go_biological_process": "GO:0045880 positive regulation of smoothened signaling pathway;GO:0000278 mitotic cell cycle;GO:0007010 cytoskeleton organization;GO:0000226 microtubule cytoskeleton organization;GO:0030030 cell projection organization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q9UJT1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A0G2JN01-1",
        "uniprot_id": [
            {
                "id": "A0A0G2JN01_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A0G2JN01",
                "type": "external"
            }
        ],
        "mass": 36023.0,
        "length": 328,
        "protein_name": "Killer cell immunoglobulin like receptor, three Ig domains pseudogene 1",
        "gene_name": "KIR3DP1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "KIR3DP1; LOC128966729",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Killer cell immunoglobulin like receptor, three Ig domains pseudogene 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
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        "pathway_count": 0,
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity;GO:0140375 immune receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0002767 immune response-inhibiting cell surface receptor signaling pathway;GO:0007154 cell communication",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "A0A0G2JN01-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000001000.001.00000",
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    },
    {
        "uniprot_canonical_ac": "Q9BZV1-1",
        "uniprot_id": [
            {
                "id": "UBXN6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BZV1",
                "type": "external"
            }
        ],
        "mass": 49754.0,
        "length": 441,
        "protein_name": "UBX domain-containing protein 6",
        "gene_name": "UBXN6",
        "organism": "Human",
        "refseq_name": "UBX domain-containing protein 6 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001164562",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164562",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "UBXN6; UBXD1; UBXDC2",
        "gene_names_refseq": "UBXD1; UBXDC2; UBXN6",
        "protein_names_uniprotkb": "UBX domain-containing protein 6; UBX domain-containing protein 1",
        "protein_names_refseq": "CTB-50L17.16; UBX domain containing 1; UBX domain-containing 2; UBX domain-containing protein 1; UBX domain-containing protein 6 isoform 2; UBX domain-containing protein 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80700)",
        "pathway_count": 1,
        "publication_count": 66,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;11342112;18083107;18656546;18669648;19174149;19275885;21822278;21896481;22337587;23335559;23349634;24366607;24715725;25418920;25576301;25645385;26475856;26992070;27600516;27753622;28218747;28228285;28467828;28514659;28832583;28834231;28904123;29242379;29393594;29437277;29508533;29557506;29632046;29786170;30315122;30379171;31154438;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33592498;33717175;33912179;33936100;33981976;34021047;34171305;34185709;34561969;35051231;35154160;35580925;36010968;36284347;37217939;37316325;37938771",
        "class_list": "",
        "function": "May negatively regulate the ATPase activity of VCP, an ATP-driven segregase that associates with different cofactors to control a wide variety of cellular processes (PubMed:26475856). As a cofactor of VCP, it may play a role in the transport of CAV1 to lysosomes for degradation (PubMed:21822278, PubMed:23335559). It may also play a role in endoplasmic reticulum-associated degradation (ERAD) of misfolded proteins (PubMed:19275885). Together with VCP and other cofactors, it may play a role in macroautophagy, regulating for instance the clearance of damaged lysosomes (PubMed:27753622)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; UBX Domain Protein 6 Positively Regulates JAK-STAT1/2 Signaling., [RefSeq, PubMed]; UBXD1 is a novel co-factor of the human p97 ATPase., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
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        "total_reported_n_glycosites": 1,
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        "secondary_ac_list": "D6W626;Q96AH1;Q96IK9;Q9BZV0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051117 ATPase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0043335 protein unfolding;GO:0016236 macroautophagy;GO:0036503 ERAD pathway;GO:0000423 mitophagy;GO:0032510 endosome to lysosome transport via multivesicular body sorting pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 7.1,
        "record_id": "Q9BZV1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96DN5-1",
        "uniprot_id": [
            {
                "id": "TBC31_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96DN5",
                "type": "external"
            }
        ],
        "mass": 124189.0,
        "length": 1066,
        "protein_name": "TBC1 domain family member 31",
        "gene_name": "TBC1D31",
        "organism": "Human",
        "refseq_name": "TBC1 domain family member 31 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001138560",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001138560",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TBC1D31; WDR67",
        "gene_names_refseq": "Gm85; TBC1D31; WDR67",
        "protein_names_uniprotkb": "TBC1 domain family member 31; WD repeat-containing protein 67",
        "protein_names_refseq": "TBC1 domain family member 31 isoform 2; WD repeat domain 67; WD repeat-containing protein 67",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:93594)",
        "pathway_count": 1,
        "publication_count": 49,
        "publication_id_list": "11237011;14654843;23481700;25418920;25576301;25880248;25892735;26154972;26375851;26638075;26992070;27600516;28904123;29437277;29493099;29557506;30315122;30484775;30779550;30833945;31092671;31154438;31222486;31530632;31844290;32157095;32161166;32350084;32502341;32938616;32983136;33298915;33592498;33691108;33912179;33934390;33968037;33981976;34171305;34932366;35051231;35251023;35580925;36010968;36241641;36284347;36581221;37468454;39206796",
        "class_list": "",
        "function": "A novel homozygous missense variant in TBC1D31 in a consanguineous family with congenital anomalies of the kidney and urinary tract (CAKUT)., [RefSeq, PubMed]; Genomic Amplification of TBC1D31 Promotes Hepatocellular Carcinoma Through Reducing the Rab22A-Mediated Endolysosomal Trafficking and Degradation of EGFR., [RefSeq, PubMed]; Molecular adapter which is involved in cilium biogenesis. Part of a functional complex including OFD1 a centriolar protein involved in cilium assembly. Could regulate the cAMP-dependent phosphorylation of OFD1, and its subsequent ubiquitination by PJA2 which ultimately leads to its proteasomal degradation., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZL19;Q2M2J9;Q3MIR6;Q8TBP9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity",
        "go_cellular_component": "GO:0005813 centrosome;GO:0034451 centriolar satellite;GO:0036064 ciliary basal body",
        "go_biological_process": "GO:0060271 cilium assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q96DN5-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86VM9-1",
        "uniprot_id": [
            {
                "id": "ZCH18_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86VM9",
                "type": "external"
            }
        ],
        "mass": 106378.0,
        "length": 953,
        "protein_name": "Zinc finger CCCH domain-containing protein 18",
        "gene_name": "ZC3H18",
        "organism": "Human",
        "refseq_name": "zinc finger CCCH domain-containing protein 18 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001281269",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001281269",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZC3H18; NHN1",
        "gene_names_refseq": "NHN1; ZC3H18",
        "protein_names_uniprotkb": "Zinc finger CCCH domain-containing protein 18; Nuclear protein NHN1",
        "protein_names_refseq": "conserved nuclear protein NHN1; zinc finger CCCH domain-containing protein 18 isoform 1; zinc finger CCCH domain-containing protein 18",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:124245);  (R-HSA-9930044)",
        "pathway_count": 2,
        "publication_count": 99,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;15302935;16964243;17081983;17174896;17287340;17412707;17924679;18077418;18212344;18220336;18452278;18491316;18669648;18691976;18707149;18767875;19367720;19413330;19415658;19608861;19651622;19664994;19664995;19690332;20058876;20068230;20068231;20166139;21406692;21705430;21855801;22706990;23186163;23301498;23481700;24275569;24715725;25218447;25578728;25755297;25880248;26154972;26811146;26992070;27434818;27846572;27871484;27920218;28832583;28834231;28904123;29242379;29298432;29493099;29508533;29557506;29789417;29906447;30192525;30315122;30379171;30429286;31604914;31844290;31950173;32157095;32357974;32488085;32502341;32897882;32938616;32960271;32983136;33123756;33298915;33592498;33691108;33717175;33767452;33913806;33968037;33981976;34087483;34171305;34185709;34561969;34932366;35051231;35318648;35580925;36010968;36241641;36284347;37217939;37612136;37875486;40473212",
        "class_list": "",
        "function": "NCBP3 positively impacts mRNA biogenesis., [RefSeq, PubMed]; ZC3H18 copy number losses could contribute to homologous recombination defects in high-grade serous ovarian cancers. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 56,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96DG4;Q96MP7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0030674 protein-macromolecule adaptor activity;GO:0140262 mRNA cap binding complex binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0032991 protein-containing complex;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0050779 RNA destabilization",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q86VM9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q92526-1",
        "uniprot_id": [
            {
                "id": "TCPW_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q92526",
                "type": "external"
            }
        ],
        "mass": 57821.0,
        "length": 530,
        "protein_name": "Probable T-complex protein 1 subunit zeta-2",
        "gene_name": "CCT6B",
        "organism": "Human",
        "refseq_name": "probable T-complex protein 1 subunit zeta-2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001180458",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180458",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CCT6B",
        "gene_names_refseq": "CCT-zeta-2; CCT6B; CCTZ-2; Cctz2; TCP-1-zeta-2; TSA303",
        "protein_names_uniprotkb": "Probable T-complex protein 1 subunit zeta-2; 3.6.1.-; CCT-zeta-2; CCT-zeta-like; Chaperonin containing T-complex polypeptide 1 subunit 6B; TCP-1-zeta-2; TCP-1-zeta-like; Testis-specific Tcp20; Testis-specific protein TSA303",
        "protein_names_refseq": "chaperonin containing TCP1, subunit 6B (zeta 2); chaperonin-containing T-complex polypeptide 1, subunit 6B; probable T-complex protein 1 subunit zeta-2 isoform 2; probable T-complex protein 1 subunit zeta-2; testis-specific Tcp20; testis-specific protein TSA303",
        "tax_id": 9606,
        "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)",
        "pathway": " (hsa:10693);  (R-HSA-389957);  (R-HSA-389960);  (R-HSA-390450);  (R-HSA-390471);  (R-HSA-6814122)",
        "pathway_count": 6,
        "publication_count": 55,
        "publication_id_list": "11237011;11466336;12502735;15889144;16415341;16702223;16717095;18775504;19011634;19376773;21098288;21995946;22424782;23481700;23637185;23747015;24756126;25342745;25467444;25576301;25645385;25659125;25675501;26154972;26375851;26992070;28832583;28904123;29242379;29557506;30429286;30524438;31844290;32265295;32357974;32387766;32938616;33043033;33298915;33392160;33592498;33691108;33912179;33936100;33968037;34171305;34509645;35008409;35051231;35561310;39894887;8812458;9013858;9153422;9819444",
        "class_list": "",
        "function": "Antagonistic actions of PhLP3 and prefoldin serve to modulate CCT activity and play a key role in establishing a functional cytoskeleton in vivo, [RefSeq, PubMed]; Could function as a component of a tissue-specific chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of actin, tubulin and other proteins upon ATP hydrolysis., [UniProtKB, UniProtKB]; Describes the cloning of a very similar protein in mouse., [RefSeq, PubMed]; This gene encodes a molecular chaperone that is a member of the chaperonin-containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DX20;B4DYB0;Q8TC34",
        "ec_number_list": [
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "1.2.1.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.12",
                "type": "external"
            },
            {
                "id": "3.5.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.-",
                "type": "external"
            },
            {
                "id": "3.5.1.98",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.98",
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            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
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            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
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            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
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            {
                "id": "3.6.4.10",
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            {
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            {
                "id": "3.2.1.45",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.45",
                "type": "external"
            },
            {
                "id": "2.4.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.-",
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            {
                "id": "3.2.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.-",
                "type": "external"
            },
            {
                "id": "3.2.1.46",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.46",
                "type": "external"
            },
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
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            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
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            },
            {
                "id": "5.6.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
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            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
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            },
            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
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            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
                "type": "external"
            },
            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
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            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
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            {
                "id": "3.1.13.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
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            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
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            {
                "id": "3.1.13.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-",
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            {
                "id": "2.7.1.91",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91",
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            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
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            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
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            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0044183 protein folding chaperone",
        "go_cellular_component": "GO:0005832 chaperonin-containing T-complex;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006457 protein folding",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "Q92526-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UBQ0-1",
        "uniprot_id": [
            {
                "id": "VPS29_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UBQ0",
                "type": "external"
            }
        ],
        "mass": 20506.0,
        "length": 182,
        "protein_name": "Vacuolar protein sorting-associated protein 29",
        "gene_name": "VPS29",
        "organism": "Human",
        "refseq_name": "vacuolar protein sorting-associated protein 29 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_057310",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057310",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "VPS29; DC15; DC7; MDS007",
        "gene_names_refseq": "DC15; DC7; PEP11; VPS29",
        "protein_names_uniprotkb": "Vacuolar protein sorting-associated protein 29; PEP11 homolog; Vesicle protein sorting 29; hVPS29",
        "protein_names_refseq": "PEP11 homolog; epididymis secretory sperm binding protein; hVPS29; retromer protein; vacuolar protein sorting 29 homolog; vacuolar protein sorting-associated protein 29 isoform 1; vacuolar protein sorting-associated protein 29; vacuolar sorting protein VPS29/PEP11; vesicle protein sorting 29; x 007 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51699);  (R-HSA-3238698)",
        "pathway_count": 2,
        "publication_count": 124,
        "publication_id_list": "10694878;11031247;11062004;11102511;11230166;11231171;11237011;11433298;12717451;15247922;15788412;16364628;16645052;16678095;16678096;16737443;17108000;17117926;17141155;17397399;17891154;18160347;18160348;18193032;18193037;18430724;19442504;19566487;19608861;19619488;19837038;20477987;20533886;20826466;20923837;21554866;21629666;21725318;21725319;21768372;21886182;22027831;22041890;22046319;22094269;22094272;22108505;22653731;22784633;22888000;22952392;22983114;23148298;23260141;23331060;23481700;23563491;24715725;24856514;25418920;25576301;25645385;25693203;25802875;25892735;26992070;27920218;28228285;28446606;28832583;28892079;28904123;29242379;29557506;29786170;30213940;30315122;30410026;30524438;30573663;30779550;31020640;31154438;31217245;31530632;31712251;31844290;32157095;32161166;32357974;32387766;32488085;32938616;33141586;33298915;33392160;33592498;33691108;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34357683;34405274;34509645;35051231;35154160;35580925;36010968;36241641;36284347;37172566;37916325;37938771;38062209;38459129;38665916;39587083;8167409;8262072;8985181",
        "class_list": "",
        "function": "(Microbial infection) The heterotrimeric retromer cargo-selective complex (CSC) mediates the exit of human papillomavirus from the early endosome and the delivery to the Golgi apparatus., [UniProtKB, PubMed]; Component of the commander complex that is essential for endosomal recycling of transmembrane cargos; the commander complex is composed of the CCC subcomplex and the retriever subcomplex (PubMed:37172566, PubMed:39587083, PubMed:38062209, PubMed:38459129). Component of the retriever complex, which is a heterotrimeric complex related to retromer cargo-selective complex (CSC) and essential for retromer-independent retrieval and recycling of numerous cargos such as integrin alpha-5/beta-1 (ITGA5:ITGB1) (PubMed:28892079, PubMed:37172566, PubMed:39587083, PubMed:38062209, PubMed:38459129). Component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway. The recruitment of the CSC to the endosomal membrane involves RAB7A and SNX3. The SNX-BAR retromer mediates retrograde transport of cargo proteins from endosomes to the trans-Golgi network (TGN) and is involved in endosome-to-plasma membrane transport for cargo protein recycling. The SNX3-retromer mediates the retrograde endosome-to-TGN transport of WLS distinct from the SNX-BAR retromer pathway. The SNX27-retromer is believed to be involved in endosome-to-plasma membrane trafficking and recycling of a broad spectrum of cargo proteins. The CSC seems to act as recruitment hub for other proteins, such as the WASH complex and TBC1D5. Required to regulate transcytosis of the polymeric immunoglobulin receptor (pIgR-pIgA) (PubMed:15247922, PubMed:21725319, PubMed:23563491). In the endosomes, retriever complex drives the retrieval and recycling of NxxY-motif-containing cargo proteins by coupling to SNX17, a cargo essential for the homeostatic maintenance of numerous cell surface proteins associated with processes that include cell migration, cell adhesion, nutrient supply and cell signaling (PubMed:28892079, PubMed:39587083). The recruitment of the retriever complex to the endosomal membrane involves CCC and WASH complexes (PubMed:28892079). Involved in GLUT1 endosome-to-plasma membrane trafficking; the function is dependent of association with ANKRD27 (PubMed:24856514)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Potential functions and causal associations of VPS29 in hepatocellular carcinoma: a bioinformatic and Mendelian randomization study., [RefSeq, PubMed]; This gene belongs to a group of vacuolar protein sorting (VPS) genes that, when functionally impaired, disrupt the efficient delivery of vacuolar hydrolases. The protein encoded by this gene is a component of a large multimeric complex, termed the retromer complex, which is involved in retrograde transport of proteins from endosomes to the trans-Golgi network. This VPS protein may be involved in the formation of the inner shell of the retromer coat for retrograde vesicles leaving the prevacuolar compartment. Alternative splice variants encoding different isoforms and representing non-protein coding transcripts have been found for this gene. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 14,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q502Y5;Q6FIF8;Q6IAH3;Q9H0W0;Q9NRP1;Q9NRU7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0030906 retromer, cargo-selective complex;GO:0005768 endosome;GO:0005769 early endosome;GO:0005829 cytosol;GO:0005770 late endosome",
        "go_biological_process": "GO:0006886 intracellular protein transport;GO:0042147 retrograde transport, endosome to Golgi;GO:0032456 endocytic recycling;GO:0015031 protein transport",
        "synthesized_glycan_count": 0,
        "hit_score": 12.7,
        "record_id": "Q9UBQ0-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UIF3-1",
        "uniprot_id": [
            {
                "id": "TEKT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UIF3",
                "type": "external"
            }
        ],
        "mass": 49672.0,
        "length": 430,
        "protein_name": "Tektin-2",
        "gene_name": "TEKT2",
        "organism": "Human",
        "refseq_name": "tektin-2",
        "refseq_ac": [
            {
                "id": "NP_055281",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055281",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TEKT2",
        "gene_names_refseq": "TEKT2; TEKTB1; TEKTIN-T; h-tektin-t",
        "protein_names_uniprotkb": "Tektin-2; TEKTB1; Tektin-B1; Tektin-t; Testicular tektin B1-like protein; Testicular tektin",
        "protein_names_refseq": "tektin 2 (testicular); tektin-2; tektin-B1; testicular tektin B1-like protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:27285)",
        "pathway_count": 1,
        "publication_count": 11,
        "publication_id_list": "11237011;11751288;12029069;18227105;31848261;35051231;36010968;36191189;36215666;36251411;39894887",
        "class_list": "",
        "function": "Integrative transcriptome analysis reveals TEKT2 and PIAS2 involvement in diabetic nephropathy., [RefSeq, PubMed]; Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme (PubMed:36191189). Plays a key role in the assembly or attachment of the inner dynein arm to microtubules in sperm flagella and tracheal cilia. Forms filamentous polymers in the walls of ciliary and flagellar microtubules., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; This gene product belongs to the tektin family of proteins. Tektins comprise a family of filament-forming proteins that are coassembled with tubulins to form ciliary and flagellar microtubules. This gene is expressed in the testis and its protein is localized to the flagella of the sperms, indicating that it may play a role in spermatogenesis. [provided by RefSeq, Jul 2008]., [RefSeq]; This is the first description of human pathology linked to a tektin-family gene, since only murine models are available for these genes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "missing_score": 0,
        "biomarker_type": "",
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        "secondary_ac_list": "A6NIS6;O60638",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0015630 microtubule cytoskeleton;GO:0005815 microtubule organizing center;GO:0036126 sperm flagellum;GO:0005814 centriole",
        "go_biological_process": "GO:0060294 cilium movement involved in cell motility;GO:0030317 flagellated sperm motility;GO:0060271 cilium assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q9UIF3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NY65-1",
        "uniprot_id": [
            {
                "id": "TBA8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NY65",
                "type": "external"
            }
        ],
        "mass": 50094.0,
        "length": 449,
        "protein_name": "Tubulin alpha-8 chain",
        "gene_name": "TUBA8",
        "organism": "Human",
        "refseq_name": "tubulin alpha-8 chain isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001180343",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180343",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TUBA8; TUBAL2",
        "gene_names_refseq": "CDCBM8; MACTHC2; TUBA8; TUBAL2",
        "protein_names_uniprotkb": "Tubulin alpha-8 chain; 3.6.5.-; Alpha-tubulin 8; Tubulin alpha chain-like 2",
        "protein_names_refseq": "tubulin alpha 8 trucated form; tubulin alpha chain-like 2; tubulin alpha-8 chain isoform 2",
        "tax_id": 9606,
        "disease": "lissencephaly (Disease Ontology:DOID:0050453); autosomal dominant isolated macrothrombocytopenia 2 (Disease Ontology:DOID:0060995); polymicrogyria (Disease Ontology:DOID:0080918); lissencephaly 3 (Disease Ontology:DOID:0112232); microlissencephaly (Disease Ontology:DOID:0112234)",
        "pathway": " (hsa:51807);  (R-HSA-1445148);  (R-HSA-190840);  (R-HSA-190861);  (R-HSA-2132295);  (R-HSA-2467813);  (R-HSA-2500257);  (R-HSA-3371497);  (R-HSA-380320);  (R-HSA-389960);  (R-HSA-389977);  (R-HSA-437239);  (R-HSA-5620920);  (R-HSA-5626467);  (R-HSA-5663220);  (R-HSA-6807878);  (R-HSA-6811434);  (R-HSA-6811436);  (R-HSA-68877);  (R-HSA-8852276);  (R-HSA-8955332);  (R-HSA-9609690);  (R-HSA-9609736);  (R-HSA-9619483);  (R-HSA-9646399);  (R-HSA-9648025);  (R-HSA-9668328);  (R-HSA-983189);  (R-HSA-9833482)",
        "pathway_count": 29,
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        "function": "Data provide evidence for a role of TUBA8 in hepatic fibrogenesis and malignancies making it a novel player in non-alcoholic steatohepatitis and hepatocellular carcinoma pathology., [RefSeq, PubMed]; Dysregulation of SAA1, TUBA8 and Monocytes Are Key Factors in Ankylosing Spondylitis With Femoral Head Necrosis. Publication Status: Online-Only, [RefSeq, PubMed]; Low TUBA8 expression is associated with 22q11.2 deletion syndrome., [RefSeq, PubMed]; Mutation of the variant alpha-tubulin TUBA8 results in polymicrogyria with optic nerve hypoplasia., [RefSeq, PubMed]; This gene encodes a member of the alpha tubulin protein family. Alpha tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. Mutations in this gene are associated with polymicrogyria and optic nerve hypoplasia. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Jul 2010]., [RefSeq]; Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
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        "protein_names_refseq": "TCEA-like protein 4; epididymis secretory sperm binding protein; transcription elongation factor A (SII)-like 4; transcription elongation factor A protein-like 4 isoform 1; transcription elongation factor A protein-like 4; transcription elongation factor S-II protein-like 4",
        "tax_id": 9606,
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        "class_list": "",
        "function": "Expression of TCEAL4 was down-regulated in all anaplastic thyroid carcinomas studied. Loss of TCEAL4 expression might be associated with development of ATC from pre-existing diffferentiated TC. Publication Status: Online-Only, [RefSeq, PubMed]; May be involved in transcriptional regulation., [UniProtKB]; This gene encodes a member of the transcription elongation factor A (SII)-like (TCEAL) gene family. This family is comprised of nuclear phosphoproteins that modulate transcription in a promoter context-dependent manner. Multiple family members are located on the X chromosome. Alternatively splicing results in multiple transcript variants. There is a pseudogene for this gene on chromosome 13. [provided by RefSeq, Apr 2015]., [RefSeq]",
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        "length": 508,
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            {
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            }
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        "gene_names_refseq": "UBXD2; UBXDC1; UBXN4; erasin",
        "protein_names_uniprotkb": "UBX domain-containing protein 4; Erasin; UBX domain-containing protein 2",
        "protein_names_refseq": "UBX domain containing 2; UBX domain-containing 1; UBX domain-containing protein 2; UBX domain-containing protein 4",
        "tax_id": 9606,
        "disease": "candidiasis (Disease Ontology:DOID:1508)",
        "pathway": " (hsa:23190)",
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        "publication_count": 79,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;16968747;17525332;18077418;19822669;21993680;23186163;23301498;23481700;24714562;24715725;25418920;25576301;26154972;26375851;26728094;26811146;26929215;26992070;27452731;27846572;27862975;27920218;28218747;28228285;28352266;28446606;28514659;28649982;28832583;28834231;28855257;28904123;29242379;29331515;29393594;29493099;29508533;29557506;29632046;29632711;29786170;30315122;30410026;30429286;30524438;30779550;31217245;31844290;32119511;32157095;32265295;32387766;32488085;32502341;32897882;32938616;32983136;33298915;33392160;33592498;33717175;33912179;33936100;33968037;33981976;34087483;34561969;34932366;35051231;35154160;35318648;35561310;35580925;36010968;36284347;37938771;40914422",
        "class_list": "",
        "function": "Erasin/UBXD2 may be involved in endoplasmic-reticulum-associated protein degradation and in Alzheimer's disease., [RefSeq, PubMed]; Involved in endoplasmic reticulum-associated protein degradation (ERAD). Acts as a platform to recruit both UBQLN1 and VCP to the ER during ERAD (PubMed:19822669)., [UniProtKB, PubMed, PubMed]; Knockdown of erasin, a platform for p97/VCP and ubiquilin binding, or knockdown of ubiquilin in human cells slowed degradation of two classical endoplasmic reticulum-associated protein degradation substrates., [RefSeq, PubMed]; UBXD2 is an integral membrane protein of the endoplasmic reticulum (ER) that binds valosin-containing protein (VCP; MIM 601023) and promotes ER-associated protein degradation (ERAD) (Liang et al., 2006 [PubMed 16968747]).[supplied by OMIM, Mar 2008]., [RefSeq]",
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        "secondary_ac_list": "A8K9W4;Q4ZG56;Q8IYM5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005635 nuclear envelope;GO:0005783 endoplasmic reticulum;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0036503 ERAD pathway;GO:0006986 response to unfolded protein",
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    },
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        "mass": 28707.0,
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        "protein_name": "Transcription cofactor vestigial-like protein 1",
        "gene_name": "VGLL1",
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        "refseq_name": "transcription cofactor vestigial-like protein 1",
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            {
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057351",
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        "gene_names_uniprotkb": "VGLL1; TDU",
        "gene_names_refseq": "TDU; VGL1; VGLL1",
        "protein_names_uniprotkb": "Transcription cofactor vestigial-like protein 1; Protein TONDU; Vgl-1",
        "protein_names_refseq": "TONDU; WUGSC:H_GS188P18.1b; transcription cofactor vestigial-like protein 1; vestigial like 1; vgl-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51442)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "10518497;11237011;24891455;31925773;33069758;33087697;35051231;37004960;38233381;38417636",
        "class_list": "",
        "function": "May act as a specific coactivator for the mammalian TEFs., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Novel EWSR1-VGLL1 fusion in a pediatric neuroepithelial neoplasm., [RefSeq, PubMed]; The protein encoded by this gene binds proteins of the TEA domain family of transcription factors (TEFs) through the Vg (vestigial) homology region found in its N-terminus. It may thus function as a specific coactivator for the mammalian TEFs. [provided by RefSeq, Sep 2009]., [RefSeq]; VGLL1 cooperates with TEAD4 to control human trophectoderm lineage specification. Erratum:[Nat Commun. 2025 Mar 18;16(1):2643. doi: 10.1038/s41467-025-57929-w. PMID: 40102433] Publication Status: Online-Only, [RefSeq, PubMed]; VGLL1 expression is associated with a triple-negative basal-like phenotype in breast cancer, [RefSeq, PubMed]; VGLL1 phosphorylation and activation promotes gastric cancer malignancy via TGF-beta/ERK/RSK2 signaling., [RefSeq, PubMed]; VGLL1 stabilization of cytoplasmic TAZ promotes EGFR expression and maintains tumor initiating cells in breast cancer independent of TEAD., [RefSeq, PubMed]; Vestigial-like 1 (VGLL1): An ancient co-transcriptional activator linking wing, placenta, and tumor development. Review article, [RefSeq, PubMed]; Vestigial-like 1 is a shared targetable cancer-placenta antigen expressed by pancreatic and basal-like breast cancers. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5H915",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003713 transcription coactivator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q99990-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y2W6-2",
        "uniprot_id": [
            {
                "id": "TDRKH_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y2W6",
                "type": "external"
            }
        ],
        "mass": 62046.0,
        "length": 561,
        "protein_name": "Tudor and KH domain-containing protein",
        "gene_name": "TDRKH",
        "organism": "Human",
        "refseq_name": "tudor and KH domain-containing protein isoform a",
        "refseq_ac": [
            {
                "id": "NP_001077432",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001077432",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TDRKH; TDRD2",
        "gene_names_refseq": "TDRD2; TDRKH",
        "protein_names_uniprotkb": "Tudor and KH domain-containing protein; Tudor domain-containing protein 2",
        "protein_names_refseq": "putative RNA binding protein; tudor and KH domain-containing protein isoform a; tudor and KH domain-containing protein; tudor domain containing 2; tudor domain-containing protein 2",
        "tax_id": 9606,
        "disease": "azoospermia (Disease Ontology:DOID:14227)",
        "pathway": " (hsa:11022);  (R-HSA-5601884)",
        "pathway_count": 2,
        "publication_count": 39,
        "publication_id_list": "10767542;15955813;17322306;18922463;20877624;21465557;22233380;23056369;23186163;23826142;23980886;24656595;25621951;27846572;27920218;28218747;28832583;28904123;29118143;29242379;29437277;29557506;29605689;30315122;30503856;31844290;31848261;32157095;32357974;32387766;32938616;33298915;33912179;33968037;34357683;35051231;35580925;38956960;40914422",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Participates in the primary piRNA biogenesis pathway and is required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. The piRNA metabolic process mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for the final steps of primary piRNA biogenesis by participating in the processing of 31-37 nt intermediates into mature piRNAs. May act in pi-bodies and piP-bodies by transferring piRNA precursors or intermediates to or between these granules., [UniProtKB, UniProtKB]; TDRKH missense mutation segregates with dominant distal hereditary motor neuropathy in a four generation pedigree., [RefSeq, PubMed]; Tudor domain proteins interact with arginine-glycine-rich motifs in a methylarginine-dependent manner., [RefSeq, PubMed]; Unlike most other Tudor domains TDRD2 preferentially recognizes an unmethylated arginine-rich sequence from PIWIL1., [RefSeq, PubMed]; Whole genome sequencing identifies a homozygous splicing variant in TDRKH segregating with non-obstructive azoospermia in an Iranian family., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DV24;Q5SZR3;Q5SZR5;Q8N582;Q9NYV5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0071546 pi-body;GO:0071547 piP-body;GO:0043186 P granule",
        "go_biological_process": "GO:0030719 P granule organization;GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0007140 male meiotic nuclear division;GO:0034587 piRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "Q9Y2W6-2",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y4F4-1",
        "uniprot_id": [
            {
                "id": "TGRM1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y4F4",
                "type": "external"
            }
        ],
        "mass": 189360.0,
        "length": 1720,
        "protein_name": "TOG array regulator of axonemal microtubules protein 1",
        "gene_name": "TOGARAM1",
        "organism": "Human",
        "refseq_name": "TOG array regulator of axonemal microtubules protein 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_055906",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055906",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TOGARAM1; FAM179B; KIAA0423",
        "gene_names_refseq": "FAM179B; JBTS37; KIAA0423; TOGARAM1",
        "protein_names_uniprotkb": "TOG array regulator of axonemal microtubules protein 1; Crescerin-1; Protein FAM179B",
        "protein_names_refseq": "TOG array regulator of axonemal microtubules protein 1 isoform 2; TOG array regulator of axonemal microtubules protein 1; crescerin-1; family with sequence similarity 179 member B; protein FAM179B",
        "tax_id": 9606,
        "disease": "Joubert syndrome (Disease Ontology:DOID:0050777); ciliopathy (Disease Ontology:DOID:0060340); Joubert syndrome 37 (MONDO:MONDO:0030933)",
        "pathway": " (hsa:23116)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "11237011;16335990;22617051;23481700;24715725;25418920;25645385;26154972;27846572;29557506;30315122;30429286;31092671;31217245;31844290;32157095;32387766;32453716;32502341;32747439;32938616;33298915;33592498;33912179;33968037;34405274;34509645;35051231;35494241;36010968;36284347;37938771",
        "class_list": "",
        "function": "Involved in ciliogenesis (PubMed:32453716). It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length (PubMed:32453716). Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4 (By similarity)., [UniProtKB, UniProtKB, UniProtKB, PubMed]; Involved in ciliogenesis. It is required for appropriate acetylation and polyglutamylation of ciliary microtubules, and regulation of cilium length. Interacts with microtubules and promotes microtubule polymerization via its HEAT repeat domains, especially those in TOG region 2 and 4., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 49,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q68D66;Q6PG27",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008017 microtubule binding",
        "go_cellular_component": "GO:0005929 cilium;GO:0005930 axoneme;GO:0036064 ciliary basal body;GO:0005881 cytoplasmic microtubule",
        "go_biological_process": "GO:0060271 cilium assembly;GO:0000226 microtubule cytoskeleton organization;GO:0031116 positive regulation of microtubule polymerization;GO:1905515 non-motile cilium assembly;GO:0035082 axoneme assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q9Y4F4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9P273-1",
        "uniprot_id": [
            {
                "id": "TEN3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9P273",
                "type": "external"
            }
        ],
        "mass": 300950.0,
        "length": 2699,
        "protein_name": "Teneurin-3",
        "gene_name": "TENM3",
        "organism": "Human",
        "refseq_name": "teneurin-3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001073946",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073946",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TENM3; KIAA1455; ODZ3; TNM3",
        "gene_names_refseq": "MCOPCB9; MCOPS15; ODZ3; TEN3; TENM3; TNM3; Ten-m3; ten-3",
        "protein_names_uniprotkb": "Teneurin-3; Protein Odd Oz/ten-m homolog 3; Ten-3; Ten-m3; Tenascin-M3; Teneurin transmembrane protein 3",
        "protein_names_refseq": "ODZ3-like protein; odz, odd Oz/ten-m homolog 3; protein Odd Oz/ten-m homolog 3; tenascin-M3; teneurin-3 isoform 1; teneurin-3; testicular tissue protein Li 195",
        "tax_id": 9606,
        "disease": "cocaine dependence (Disease Ontology:DOID:9975); microphthalmia, isolated, with coloboma 9 (MONDO:MONDO:0014059)",
        "pathway": " (hsa:55714)",
        "pathway_count": 1,
        "publication_count": 54,
        "publication_id_list": "10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10625539;11237011;22299025;22766609;24190977;25813380;25880248;25892735;27103084;28904123;29351928;29393594;29557506;29605689;29731959;29753094;29789417;30315122;30377343;30429286;30484775;30513139;30779550;31154438;31222486;31844290;32157095;32161166;32357974;32387766;32938616;32960451;33298915;33392160;33592498;33912179;33968037;33981976;34087483;34174923;34357683;35051231;35154160;35494241;35580925;36010968;36241641;36284347;37074911;37217939;37938771;38665916",
        "class_list": "",
        "function": "Involved in neural development by regulating the establishment of proper connectivity within the nervous system. Acts in both pre- and postsynaptic neurons in the hippocampus to control the assembly of a precise topographic projection: required in both CA1 and subicular neurons for the precise targeting of proximal CA1 axons to distal subiculum, probably by promoting homophilic cell adhesion. Required for proper dendrite morphogenesis and axon targeting in the vertebrate visual system, thereby playing a key role in the development of the visual pathway. Regulates the formation in ipsilateral retinal mapping to both the dorsal lateral geniculate nucleus (dLGN) and the superior colliculus (SC). May also be involved in the differentiation of the fibroblast-like cells in the superficial layer of mandibular condylar cartilage into chondrocytes., [UniProtKB, UniProtKB]; Null mutation in ODZ3 causes autosomal recessive microphthalmia in humans., [RefSeq, PubMed]; Replicative verification of susceptibility genes previously identified from families with segregating developmental dysplasia of the hip. Publication Status: Online-Only, [RefSeq, PubMed]; Ten-m/Odz3 regulates migration and differentiation of chondrogenic ATDC5 cells via RhoA-mediated actin reorganization., [RefSeq, PubMed]; This gene encodes a member of the teneurin transmembrane protein family. The encoded protein may be involved in the regulation of neuronal development including development of the visual pathway. Mutations in this gene have been associated with microphthalmia and developmental dysplasia of the hip. [provided by RefSeq, Jan 2023]., [RefSeq]",
        "predicted_glycosites": 9,
        "predicted_n_glycosites": 9,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 8,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 9,
        "reported_o_glycosites_with_glycan": 6,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 9,
        "total_reported_o_glycosites": 6,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 9,
        "total_o_glycosites": 6,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 143,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 23,
        "disease_count": 2,
        "glyco_site_count": 24,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5XUL9;Q96SY2;Q9NV77;Q9NVW1;Q9NZJ2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0050839 cell adhesion molecule binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030424 axon;GO:0043005 neuron projection",
        "go_biological_process": "GO:0007165 signal transduction;GO:0010976 positive regulation of neuron projection development;GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0048666 neuron development;GO:0048593 camera-type eye morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "Q9P273-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.001000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NT68-1",
        "uniprot_id": [
            {
                "id": "TEN2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NT68",
                "type": "external"
            }
        ],
        "mass": 307787.0,
        "length": 2774,
        "protein_name": "Teneurin-2",
        "gene_name": "TENM2",
        "organism": "Human",
        "refseq_name": "teneurin-2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001073897",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001073897",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TENM2; KIAA1127; ODZ2; TNM2",
        "gene_names_refseq": "ODZ2; TEN-M2; TEN2; TENM2; TNM2; ten-2",
        "protein_names_uniprotkb": "Teneurin-2; Protein Odd Oz/ten-m homolog 2; Ten-2; Ten-m2; Tenascin-M2; Teneurin transmembrane protein 2",
        "protein_names_refseq": "neurestin alpha; odd Oz/ten-m homolog 2; odz, odd Oz/ten-m homolog 2; protein Odd Oz/ten-m homolog 2; tenascin-M2; teneurin-2 isoform 2; teneurin-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:57451)",
        "pathway_count": 1,
        "publication_count": 32,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;12783990;18927281;21724987;23090970;24190977;25502872;25892735;28088466;28411811;28832583;28904123;29557506;29741879;30315122;30457553;31222486;31844290;31848261;32157095;32161166;32350084;32938616;32983136;33298915;33592498;33968037;35051231;35580925;36010968;37074911",
        "class_list": "",
        "function": "Acts as a ligand of the ADGRL1 receptor. Mediates axon guidance and heterophilic cell-cell adhesion., [UniProtKB, PubMed]; Gene rearrangements of ODZ2 is associated with mucosa-associated lymphoid tissue lymphoma., [RefSeq, PubMed]; Induces gene transcription inhibition., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Intracellular domain of teneurin-2 has a nuclear function and role in repressing zic-1-mediated transcription, [RefSeq, PubMed]; Involved in neural development, regulating the establishment of proper connectivity within the nervous system (PubMed:21724987). Acts as a ligand of the ADGRL1 and ADGRL3 receptors that are expressed at the surface of adjacent cells (PubMed:21724987). Promotes the formation of filopodia and enlarged growth cone in neuronal cells (PubMed:21724987). Mediates axon guidance and homophilic and heterophilic cell-cell adhesion (PubMed:21724987). May function as a cellular signal transducer (PubMed:21724987)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TENM2 knockdown induces both UCP1 mRNA and protein expression upon adipogenic differentiation without affecting mitochondrial mass., [RefSeq, PubMed]; These findings reveal a novel mechanism of axonal pathfinding, whereby latrophilin-1 and Lasso mediate both short-range interaction that supports synaptogenesis, and long-range signaling that induces axonal attraction. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 14,
        "predicted_n_glycosites": 12,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 149,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 11,
        "disease_count": 0,
        "glyco_site_count": 17,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9ULU2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0042803 protein homodimerization activity;GO:0046982 protein heterodimerization activity;GO:0005509 calcium ion binding;GO:0050839 cell adhesion molecule binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane;GO:0005911 cell-cell junction",
        "go_biological_process": "GO:0098942 retrograde trans-synaptic signaling by trans-synaptic protein complex;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0098609 cell-cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q9NT68-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.001000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96QE5-1",
        "uniprot_id": [
            {
                "id": "TEFM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96QE5",
                "type": "external"
            }
        ],
        "mass": 41676.0,
        "length": 360,
        "protein_name": "Transcription elongation factor, mitochondrial",
        "gene_name": "TEFM",
        "organism": "Human",
        "refseq_name": "transcription elongation factor, mitochondrial",
        "refseq_ac": [
            {
                "id": "NP_078959",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_078959",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TEFM; C17orf42",
        "gene_names_refseq": "C17orf42; COXPD58; TEFM",
        "protein_names_uniprotkb": "Transcription elongation factor, mitochondrial",
        "protein_names_refseq": "transcription elongation factor of mitochondria; transcription elongation factor, mitochondrial",
        "tax_id": 9606,
        "disease": "combined oxidative phosphorylation deficiency (Disease Ontology:DOID:0060286); combined oxidative phosphorylation deficiency 58 (MONDO:MONDO:0957537)",
        "pathway": " (hsa:79736)",
        "pathway_count": 1,
        "publication_count": 35,
        "publication_id_list": "11237011;11468690;19291764;21278163;24715725;25576301;25690892;26992070;28228285;28510447;28514659;28834231;28904123;29033127;30315122;30379171;31154438;31217245;31844290;31848261;32387766;32488085;32938616;33298915;33717175;33771980;33912179;33968037;35051231;35580925;36010968;36241641;36284347;36823193;40596516",
        "class_list": "",
        "function": "Data indicate transcription elongation factor (TEFM) as an essential component of the mitochondrial transcription machinery., [RefSeq, PubMed]; Data provide insights into target specificity of TEFM and mechanisms by which it regulates the switch between transcription and replication of mitochondrial DNA., [RefSeq, PubMed]; Elevated TEFM expression promotes growth and metastasis through activation of ROS/ERK signaling in hepatocellular carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; TEFM variants impair mitochondrial transcription causing childhood-onset neurological disease. Publication Status: Online-Only, [RefSeq, PubMed]; The TEFM protein is proposed to be a critical component of the transcription apparatus of human mitochondria., [RefSeq, PubMed]; Transcription elongation factor which increases mitochondrial RNA polymerase processivity (PubMed:21278163, PubMed:36823193). Regulates transcription of the mitochondrial genome, including genes important for the oxidative phosphorylation machinery (PubMed:21278163, PubMed:36823193)., [UniProtKB, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
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        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P655;Q6GPG5;Q6PJ19;Q96H04;Q9H5Z9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003711 transcription elongation factor activity",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix;GO:0042645 mitochondrial nucleoid;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0006392 transcription elongation by mitochondrial RNA polymerase;GO:0002082 regulation of oxidative phosphorylation;GO:1903109 positive regulation of mitochondrial transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 3.8,
        "record_id": "Q96QE5-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96M53-1",
        "uniprot_id": [
            {
                "id": "TBATA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96M53",
                "type": "external"
            }
        ],
        "mass": 39460.0,
        "length": 351,
        "protein_name": "Protein TBATA",
        "gene_name": "TBATA",
        "organism": "Human",
        "refseq_name": "protein TBATA isoform b",
        "refseq_ac": [
            {
                "id": "NP_001305171",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305171",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TBATA; C10orf27; SPATIAL",
        "gene_names_refseq": "C10orf27; SPATIAL; TBATA",
        "protein_names_uniprotkb": "Protein TBATA; Protein SPATIAL; Stromal protein associated with thymii and lymph node homolog; Thymus, brain and testes-associated protein",
        "protein_names_refseq": "protein TBATA isoform b; protein TBATA; stromal protein associated with thymii and lymph node homolog; thymus, brain and testes-associated protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:219793)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;17196196;17961552;18208870;19918778;20937703;23719902;35494241",
        "class_list": "",
        "function": "C10orf27 is a candidate gene for multiple sclerosis susceptibility and pathogenesis GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Functional analysis of the orthologous mouse protein., [RefSeq, PubMed, PubMed, PubMed, PubMed]; May play a role in spermatid differentiation. Modulates thymic stromal cell proliferation and thymus function., [UniProtKB]; This gene encodes a protein that regulates thymic epithelial cell proliferation and thymus size. It has been identified as a ligand for the class I human leukocyte antigen (HLA-I) in thymus. Studies of the orthologous mouse protein suggest that it may also play a role in spermatid differentiation, as well as in neuronal morphogenesis and synaptic plasticity. Polymorphisms in this gene are associated with susceptibility for multiple sclerosis (MS). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A4QPA8;B2RPQ2;Q5T4G2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0036064 ciliary basal body",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q96M53-1",
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        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6URK8-1",
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            {
                "id": "SMIP8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6URK8",
                "type": "external"
            }
        ],
        "mass": 24810.0,
        "length": 216,
        "protein_name": "Sperm microtubule inner protein 8",
        "gene_name": "SPMIP8",
        "organism": "Human",
        "refseq_name": "sperm microtubule inner protein 8 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_950247",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_950247",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SPMIP8; TEPP",
        "gene_names_refseq": "SPMIP8; TEPP",
        "protein_names_uniprotkb": "Sperm microtubule inner protein 8; Testis, prostate and placenta-expressed protein",
        "protein_names_refseq": "sperm microtubule inner protein 8 isoform 1; testicular tissue protein Li 196; testis, prostate and placenta expressed; testis, prostate and placenta-expressed protein; testis/prostate/placenta-expressed protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:374739)",
        "pathway_count": 1,
        "publication_count": 1,
        "publication_id_list": "14652002",
        "class_list": "",
        "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "secondary_ac_list": "Q6URK7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0036126 sperm flagellum;GO:0160111 axonemal A tubule inner sheath",
        "go_biological_process": "GO:0030317 flagellated sperm motility",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q6URK8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZNM6-1",
        "uniprot_id": [
            {
                "id": "SMI10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZNM6",
                "type": "external"
            }
        ],
        "mass": 15452.0,
        "length": 134,
        "protein_name": "Sperm-associated microtubule inner protein 10",
        "gene_name": "SPMIP10",
        "organism": "Human",
        "refseq_name": "sperm-associated microtubule inner protein 10",
        "refseq_ac": [
            {
                "id": "NP_997291",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_997291",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SPMIP10; C5orf48; TEX43",
        "gene_names_refseq": "C5orf48; SPMIP10; TEX43; Tseg7",
        "protein_names_uniprotkb": "Sperm-associated microtubule inner protein 10; Testis-expressed protein 43",
        "protein_names_refseq": "sperm associated microtubule inner protein 10; sperm-associated microtubule inner protein 10; testis expressed 43; testis specific expressed gene 7; testis-expressed sequence 43 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:389320)",
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        "publication_count": 0,
        "publication_id_list": "",
        "class_list": "",
        "function": "Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in flagellum axoneme, which is required for flagellum beating. May serve to reinforce and thus stabilize the microtubule structure in the sperm flagella. Involved in the regulation of sperm motility., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_s_glycosites": 0,
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        "go_molecular_function": "",
        "go_cellular_component": "GO:0036126 sperm flagellum;GO:0160112 axonemal B tubule inner sheath",
        "go_biological_process": "GO:0030317 flagellated sperm motility",
        "synthesized_glycan_count": 0,
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        "record_id": "Q6ZNM6-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
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            {
                "id": "TCF24_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7RTU0",
                "type": "external"
            }
        ],
        "mass": 17516.0,
        "length": 167,
        "protein_name": "Transcription factor 24",
        "gene_name": "TCF24",
        "organism": "Human",
        "refseq_name": "transcription factor 24",
        "refseq_ac": [
            {
                "id": "NP_001180431",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180431",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TCF24",
        "gene_names_refseq": "TCF-24; TCF24; bHLHa25",
        "protein_names_uniprotkb": "Transcription factor 24; TCF-24",
        "protein_names_refseq": "transcription factor 24",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:100129654)",
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        "publication_count": 3,
        "publication_id_list": "14516699;33392160;35051231",
        "class_list": "",
        "function": "Putative transcription factor., [UniProtKB]",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "H3BPR9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046983 protein dimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0032502 developmental process",
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        "record_id": "Q7RTU0-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
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                "type": "external"
            }
        ],
        "mass": 25407.0,
        "length": 230,
        "protein_name": "Inactive L-threonine 3-dehydrogenase, mitochondrial",
        "gene_name": "TDH",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "TDH; SDR14E1P",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Inactive L-threonine 3-dehydrogenase, mitochondrial; Short chain dehydrogenase/reductase family 14E member 1 pseudogene",
        "protein_names_refseq": "",
        "tax_id": 9606,
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        "publication_id_list": "12361482;32983136;35580925",
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        "secondary_ac_list": "Q8IZJ5;Q96LV6",
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        "go_cellular_component": "GO:0005739 mitochondrion",
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        "record_id": "Q8IZJ6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IZS6-1",
        "uniprot_id": [
            {
                "id": "DYLT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IZS6",
                "type": "external"
            }
        ],
        "mass": 23176.0,
        "length": 198,
        "protein_name": "Dynein light chain Tctex-type protein 2",
        "gene_name": "DYNLT2",
        "organism": "Human",
        "refseq_name": "dynein light chain Tctex-type protein 2",
        "refseq_ac": [
            {
                "id": "NP_777570",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_777570",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "DYNLT2; TCTE3; TCTEX1D3",
        "gene_names_refseq": "DYNLT2; TCTE3; TCTEX1D3; TCTEX2; Tctex4; oda12",
        "protein_names_uniprotkb": "Dynein light chain Tctex-type protein 2; T-complex testis-specific protein 3; T-complex-associated testis-expressed protein 3; Tcte-3; Tctex1 domain-containing protein 3",
        "protein_names_refseq": "T-complex testis-specific protein 3; T-complex-associated testis-expressed protein 3; Tctex1 domain containing 3; dynein light chain Tctex-type protein 2; t-complex-associated-testis-expressed 3; tctex1 domain-containing protein 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6991);  (R-HSA-5620924)",
        "pathway_count": 2,
        "publication_count": 58,
        "publication_id_list": "10069812;11278908;11285270;12584439;12795688;15231740;15269286;15489852;15523559;15955805;16049494;16435301;16492809;16775004;16782012;17312020;17314406;17574030;18180368;18304522;18364699;18369462;18852297;19112494;19147001;19253336;19384852;19450523;19720863;19805633;20435895;20526327;20526328;20530210;20889716;21085971;21427764;21936775;22118932;22922713;22992454;23945166;23990561;24140113;24296415;24596149;24616010;25205765;25349261;25443296;29079176;32749594;8516294;8522608;9114011;9585416;9585417;9852153",
        "class_list": "",
        "function": "Because TCTE3 encodes a putative light chain of the outer dynein arm of cilia and human diseases caused by ciliary dysfunction show various phenotypes including skeletal defect, TCTE3 may be a genetic candidate influencing CDH. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Component of dynein, a family of motor proteins essential for movement along microtubules (PubMed:11278908, PubMed:12584439). Required for structural and functional integrity of cilia (By similarity). Candidate for involvement in male sterility (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB]; Study of Linc00574 Regulatory Effect on the TCTE3 Expression in Sperm Motility., [RefSeq, PubMed]; TCTE3 is a useful marker of pancreatobiliary differentiation and may aid in the diagnosis of pancreatobiliary adenocarcinomas., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_mutagensis": 0,
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        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0045505 dynein intermediate chain binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005874 microtubule;GO:0016020 membrane;GO:0005868 cytoplasmic dynein complex",
        "go_biological_process": "GO:0007018 microtubule-based movement",
        "synthesized_glycan_count": 0,
        "hit_score": 5.9,
        "record_id": "Q8IZS6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NAT2-3",
        "uniprot_id": [
            {
                "id": "TDRD5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NAT2",
                "type": "external"
            }
        ],
        "mass": 109737.0,
        "length": 981,
        "protein_name": "Tudor domain-containing protein 5",
        "gene_name": "TDRD5",
        "organism": "Human",
        "refseq_name": "tudor domain-containing protein 5 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001186014",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001186014",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TDRD5; TUDOR3",
        "gene_names_refseq": "TDRD5; TUDOR3",
        "protein_names_uniprotkb": "Tudor domain-containing protein 5",
        "protein_names_refseq": "testicular tissue protein Li 194; tudor domain-containing protein 5 isoform 1; tudor domain-containing protein 5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:163589)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "19536175;20302647;20305267;24714562;29786170;32059713;32161166;34087483;35051231;35580925",
        "class_list": "",
        "function": "Here we evaluate gene and protein expression levels of four key TDRDs (TDRD1, TDRD5, TDRD9 and TDRD12) in testicular biopsy samples obtained from men with obstructive azoospermia (OA, n = 29), as controls, and various types of non-obstructive azoospermia containing hypospermatogenesis (HP, 28), maturation arrest (MA, n = 30), and Sertoli cell-only syndrome (SCOS, n = 32) as cases. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Required during spermiogenesis to participate in the repression transposable elements and prevent their mobilization, which is essential for the germline integrity. Probably acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Required for chromatoid body (CB) assembly (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 12,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A1L4G5;B7ZLV0;Q5EBN4;Q5VTV0;Q6ZSK2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0045202 synapse;GO:0071546 pi-body;GO:0033391 chromatoid body",
        "go_biological_process": "GO:0030719 P granule organization;GO:0007286 spermatid development;GO:0141196 transposable element silencing by piRNA-mediated DNA methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q8NAT2-3",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NDG6-1",
        "uniprot_id": [
            {
                "id": "TDRD9_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NDG6",
                "type": "external"
            }
        ],
        "mass": 155683.0,
        "length": 1382,
        "protein_name": "ATP-dependent RNA helicase TDRD9",
        "gene_name": "TDRD9",
        "organism": "Human",
        "refseq_name": "ATP-dependent RNA helicase TDRD9",
        "refseq_ac": [
            {
                "id": "NP_694591",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694591",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TDRD9; C14orf75",
        "gene_names_refseq": "C14orf75; HIG-1; HLS; NET54; SPGF30; SPNE; TDRD9",
        "protein_names_uniprotkb": "ATP-dependent RNA helicase TDRD9; 3.6.4.13; Tudor domain-containing protein 9",
        "protein_names_refseq": "ATP-dependent RNA helicase TDRD9; hypoxia-inducible HIG-1; putative ATP-dependent RNA helicase TDRD9; tudor domain-containing protein 9",
        "tax_id": 9606,
        "disease": "spermatogenic failure 30 (Disease Ontology:DOID:0111913)",
        "pathway": " (hsa:122402);  (R-HSA-5601884)",
        "pathway_count": 2,
        "publication_count": 22,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;18922463;19308021;20414141;20549515;21465557;22233380;23056369;23826142;23980886;24656595;27600516;28536242;30484775;31844290;32036563;32059713;32938616;32983136;35051231;37074911",
        "class_list": "",
        "function": "ATP-binding RNA helicase required during spermatogenesis (PubMed:28536242). Required to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Acts downstream of piRNA biogenesis: exclusively required for transposon silencing in the nucleus, suggesting that it acts as a nuclear effector in the nucleus together with PIWIL4., [UniProtKB, PubMed, UniProtKB]; First report of a recessive deleterious mutation in TDRD9 in humans; study demonstrates that non-obstructive azoospermia can be caused by a mutation in TDRD9, [RefSeq, PubMed]; Here we evaluate gene and protein expression levels of four key TDRDs (TDRD1, TDRD5, TDRD9 and TDRD12) in testicular biopsy samples obtained from men with obstructive azoospermia (OA, n = 29), as controls, and various types of non-obstructive azoospermia containing hypospermatogenesis (HP, 28), maturation arrest (MA, n = 30), and Sertoli cell-only syndrome (SCOS, n = 32) as cases. Publication Status: Online-Only, [RefSeq, PubMed]; Mutational alterations of TDRD 1, 4 and 9 genes in colorectal cancers., [RefSeq, PubMed]; Observational study and genome-wide association study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]",
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        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 9507,
        "biomarker_type": "",
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        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A4S7;Q6ZU54;Q8N7T3;Q8N827;Q8N9V5;Q96AS9",
        "ec_number_list": [
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
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            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
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            },
            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
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            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
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            },
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
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            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
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            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
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                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
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            },
            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
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            },
            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
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            },
            {
                "id": "2.1.1.386",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.386",
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            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
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                "id": "2.7.11.1",
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            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
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            {
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            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
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            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
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            },
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
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            },
            {
                "id": "3.1.13.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
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            },
            {
                "id": "5.6.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
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            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
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            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0004386 helicase activity;GO:0003724 RNA helicase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0071547 piP-body",
        "go_biological_process": "GO:0007283 spermatogenesis;GO:0009566 fertilization;GO:0030154 cell differentiation;GO:0007140 male meiotic nuclear division;GO:0034587 piRNA processing",
        "synthesized_glycan_count": 0,
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        "kg_view_protein": true
    },
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            {
                "id": "TET1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NFU7",
                "type": "external"
            }
        ],
        "mass": 235309.0,
        "length": 2136,
        "protein_name": "Methylcytosine dioxygenase TET1",
        "gene_name": "TET1",
        "organism": "Human",
        "refseq_name": "methylcytosine dioxygenase TET1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_085128",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085128",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TET1; CXXC6; KIAA1676; LCX",
        "gene_names_refseq": "CXXC6; LCX; TET1; bA119F7.1",
        "protein_names_uniprotkb": "Methylcytosine dioxygenase TET1; 1.14.11.80; CXXC-type zinc finger protein 6; Leukemia-associated protein with a CXXC domain; Ten-eleven translocation 1 gene protein",
        "protein_names_refseq": "CXXC finger 6; CXXC zinc finger 6; CXXC-type zinc finger protein 6; leukemia-associated protein with a CXXC domain; methylcytosine dioxygenase TET1 isoform 2; methylcytosine dioxygenase TET1; ten-eleven translocation 1 gene protein; ten-eleven translocation-1; tet oncogene 1",
        "tax_id": 9606,
        "disease": "hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:80312);  (R-HSA-5221030)",
        "pathway_count": 2,
        "publication_count": 57,
        "publication_id_list": "12124344;12646957;16385451;18163421;18587051;19372391;19372393;19651622;20639862;21057493;21321204;21490601;21496894;21778364;21817016;21862836;22327402;22962365;23186163;23403289;23548903;23727577;23812591;24315485;24357321;24394411;25284789;25557551;26992070;27259240;27397612;28397838;28411811;28531272;28834231;29276034;29351928;29557506;30192525;31278917;32157095;32387766;32502341;32938616;33833093;34561969;35051231;35798741;36010968;36056023;37231419;37541260;37610277;37643326;37995981;38369780;38431880",
        "class_list": "",
        "function": "DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015]., [RefSeq]; Demonstrated that TET1 is fused to MLL in a case of pediatric acute myeloid leukemia containing the t(10;11)(q22;q23), [RefSeq, PubMed]; Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). As isoform 1, binds to promoters, particularly to those with high CG content, however displays reduced global chromatin affinity compared with isoform 1, leading to decreased global DNA demethylation compared with isoform 1 (By similarity). Contrary to isoform 1, isoform 2 localizes during S phase to sites of ongoing DNA replication in heterochromatin, causing a significant de novo 5hmC formation, globally, and more so in heterochromatin, including LINE 1 interspersed DNA repeats leading to their activation (By similarity). In hippocampal neurons, isoform 2 regulates the expression of a unique subset of genes compared to isoform 1, although some overlap between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 2 controls miniature excitatory postsynaptic current frequency, but not amplitude (By similarity). Isoform 2 may regulate genes involved in hippocampal-dependent memory, leading to negative regulation of memory, contrary to isoform 1 that may improve memory (By similarity). In immature and partially differentiated gonadotrope cells, directly represses luteinizing hormone gene LHB expression and does not catalyze 5hmC at the gene promoter (By similarity)., [UniProtKB, UniProtKB, PubMed]; Dioxygenase that plays a key role in active DNA demethylation (PubMed:28531272). Binds to promoters, particularly to those with high CG content (By similarity). In hippocampal neurons, isoform 1 regulates the expression of a unique subset of genes compared to isoform 2, although some overlap exists between both isoforms, hence differentially regulates excitatory synaptic transmission (By similarity). In hippocampal neuron cell cultures, isoform 1 controls both miniature excitatory postsynaptic current amplitude and frequency (By similarity). Isoform 1 may regulate genes involved in hippocampal-dependent memory, leading to positive regulation of memory, contrary to isoform 2 that may decrease memory (By similarity)., [UniProtKB, UniProtKB, PubMed]; Dioxygenase that plays a key role in active DNA demethylation, by catalyzing the sequential oxidation of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5caC) (PubMed:19372391, PubMed:21496894, PubMed:21778364, PubMed:35798741). In addition to its role in DNA demethylation, plays a more general role in chromatin regulation by recruiting histone modifying protein complexes to alter histone marks and chromatin accessibility, leading to both activation and repression of gene expression (PubMed:33833093). Plays therefore a role in many biological processes, including stem cell maintenance, T- and B-cell development, inflammation regulation, genomic imprinting, neural activity or DNA repair (PubMed:31278917). Involved in the balance between pluripotency and lineage commitment of cells and plays a role in embryonic stem cells maintenance and inner cell mass cell specification. Together with QSER1, plays an essential role in the protection and maintenance of transcriptional and developmental programs to inhibit the binding of DNMT3A/3B and therefore de novo methylation (PubMed:33833093). May play a role in pancreatic beta-cell specification during development. In this context, may function as an upstream epigenetic regulator of PAX4 presumably through direct recruitment by FOXA2 to a PAX4 enhancer to preserve its unmethylated status, thereby potentiating PAX4 expression to adopt beta-cell fate during endocrine lineage commitment (PubMed:35798741). Under DNA hypomethylation conditions, such as in female meiotic germ cells, may induce epigenetic reprogramming of pericentromeric heterochromatin (PCH), the constitutive heterochromatin of pericentromeric regions. PCH forms chromocenters in the interphase nucleus and chromocenters cluster at the prophase of meiosis. In this context, may also be essential for chromocenter clustering in a catalytic activity-independent manner, possibly through the recruitment polycomb repressive complex 1 (PRC1) to the chromocenters (By similarity). During embryonic development, may be required for normal meiotic progression in oocytes and meiotic gene activation (By similarity). Binds preferentially to DNA containing cytidine-phosphate-guanosine (CpG) dinucleotides over CpH (H=A, T, and C), hemimethylated-CpG and hemimethylated-hydroxymethyl-CpG (PubMed:29276034)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; LINC00891 Attenuates the Proliferation and Metastasis of Osteosarcoma Cells via miR-27a-3p/TET1 Axis., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Significant association with late-onset Alzheimer's disease for 4 SNPs: rs1881747 near DKK1, rs2279420 in ANK3, rs2306402 in CTNNA3, and rs5030882 in CXXC6 in 1,160 cases and 1,389 controls. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; TET1 Regulates Skeletal Stem-Cell Mediated Cartilage Regeneration., [RefSeq, PubMed]; TET1 inhibits liver fibrosis by blocking hepatic stellate cell activation., [RefSeq, PubMed]; TET1 inhibits the migration and invasion of cervical cancer cells by regulating autophagy., [RefSeq, PubMed]; TET1 regulates stem cell properties and cell cycle of Cancer stem cells in triple-negative breast cancer via DNA demethylation., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 119,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A023HHK9;A0A023HHL0;Q5VUP7;Q7Z6B6;Q8TCR1;Q9C0I7",
        "ec_number_list": [
            {
                "id": "1.14.11.80",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.80",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0005506 iron ion binding;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0008327 methyl-CpG binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0031965 nuclear membrane;GO:0005694 chromosome",
        "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:1902455 negative regulation of stem cell population maintenance;GO:0044029 positive regulation of gene expression via chromosomal CpG island demethylation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006338 chromatin remodeling",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q8NFU7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96SF2-1",
        "uniprot_id": [
            {
                "id": "TCPQM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96SF2",
                "type": "external"
            }
        ],
        "mass": 59388.0,
        "length": 557,
        "protein_name": "T-complex protein 1 subunit theta-like 2",
        "gene_name": "CCT8L2",
        "organism": "Human",
        "refseq_name": "T-complex protein 1 subunit theta-like 2",
        "refseq_ac": [
            {
                "id": "NP_055221",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055221",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CCT8L2; CESK1",
        "gene_names_refseq": "CCT8L2; CESK1",
        "protein_names_uniprotkb": "T-complex protein 1 subunit theta-like 2; Chaperonin containing T-complex polypeptide 1 subunit 8-like 2",
        "protein_names_refseq": "T-complex protein 1 subunit theta-like 2; chaperonin containing T-complex polypeptide 1 subunit 8-like 2; chaperonin containing TCP1, subunit 8 (theta)-like 2; putative T-complex protein 1 subunit theta-like 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:150160)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "10585773;20193073;26768311;28218747;30444036;31154438;32938616;35051231",
        "class_list": "",
        "function": "Possible molecular chaperone; assists the folding of proteins upon ATP hydrolysis., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4QPH3;Q9UJS3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0051082 unfolded protein binding;GO:0005253 monoatomic anion channel activity;GO:0015269 calcium-activated potassium channel activity;GO:0140662 ATP-dependent protein folding chaperone",
        "go_cellular_component": "GO:0005832 chaperonin-containing T-complex",
        "go_biological_process": "GO:0006457 protein folding",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q96SF2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BYX2-1",
        "uniprot_id": [
            {
                "id": "TBD2A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BYX2",
                "type": "external"
            }
        ],
        "mass": 105414.0,
        "length": 928,
        "protein_name": "TBC1 domain family member 2A",
        "gene_name": "TBC1D2",
        "organism": "Human",
        "refseq_name": "TBC1 domain family member 2A isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001254500",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254500",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TBC1D2; PARIS1; PP8997; TBC1D2A",
        "gene_names_refseq": "PARIS-1; PARIS1; TBC1D2A; TBC1D2",
        "protein_names_uniprotkb": "TBC1 domain family member 2A; Armus; PARIS-1; Prostate antigen recognized and identified by SEREX 1",
        "protein_names_refseq": "TBC1 domain family member 2A isoform 1; TBC1 domain family, member 2A; armus; prostate antigen recognized and identified by SEREX 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55357);  (R-HSA-8854214)",
        "pathway_count": 2,
        "publication_count": 65,
        "publication_id_list": "10202141;11785977;16055087;16395330;17081983;17658474;17901050;18199687;18319245;18466115;18669648;19077034;20095038;20116244;20363736;20404108;20944657;21383079;21458671;22219378;22613832;22762500;22795129;22854040;23019362;23285084;23481700;23562278;24715725;27862975;28218747;28904123;29242379;29437277;29557506;29786170;30315122;30379171;30429286;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32938616;32983136;33123756;33298915;33592498;33912179;33968037;33981976;34087483;34405274;34509645;35051231;35318648;35494241;35580925;36010968;36284347;37217939;37938771",
        "class_list": "",
        "function": "Acts as a GTPase-activating protein for RAB7A. Signal effector acting as a linker between RAC1 and RAB7A, leading to RAB7A inactivation and subsequent inhibition of cadherin degradation and reduced cell-cell adhesion., [UniProtKB, PubMed]; Armus expression induces autophagosome accumulation in keratinocytes., [RefSeq, PubMed]; Integration of Rac1 and Rab7 activities by Armus provides an important regulatory node for E-cadherin turnover and stability of cell-cell contacts, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; TBC1D2/Armus, a GAP of Rab7 GTPase, is reported as a novel target of miR-17., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 1,
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        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
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        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWD1;B4DQ05;B9A6J7;Q59EU0;Q5TBQ5;Q6IPC7;Q7L1K8;Q8WYT1;Q9H6A2;Q9NSH4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity;GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030054 cell junction;GO:0031410 cytoplasmic vesicle",
        "go_biological_process": "GO:0043547 positive regulation of GTPase activity",
        "synthesized_glycan_count": 0,
        "hit_score": 6.8,
        "record_id": "Q9BYX2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9HAU6-1",
        "uniprot_id": [
            {
                "id": "TCTP8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9HAU6",
                "type": "external"
            }
        ],
        "mass": 15994.0,
        "length": 139,
        "protein_name": "Putative translationally-controlled tumor protein-like protein TPT1P8",
        "gene_name": "TPT1P8",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "TPT1P8; FKSG2",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative translationally-controlled tumor protein-like protein TPT1P8; Putative apoptosis inhibitor FKSG2",
        "protein_names_refseq": "",
        "tax_id": 9606,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "Q9HAU6-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UFV1-1",
        "uniprot_id": [
            {
                "id": "TBC29_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UFV1",
                "type": "external"
            }
        ],
        "mass": 16280.0,
        "length": 150,
        "protein_name": "Putative TBC1 domain family member 29",
        "gene_name": "TBC1D29P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "TBC1D29P; TBC1D29",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative TBC1 domain family member 29",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "24715725",
        "class_list": "",
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        "predicted_glycosites": 0,
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        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
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        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
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        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q9UFV1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A0A075B6V0-1",
        "uniprot_id": [
            {
                "id": "A0A075B6V0_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A0A075B6V0",
                "type": "external"
            }
        ],
        "mass": 2251.0,
        "length": 20,
        "protein_name": "T cell receptor alpha joining 16",
        "gene_name": "TRAJ16",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "TRAJ16",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "T cell receptor alpha joining 16",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "11237011",
        "class_list": "",
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        "refseq_name": "putative killer cell immunoglobulin-like receptor like protein KIR3DP1",
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            {
                "id": "XP_054189416",
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            {
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        "go_molecular_function": "GO:0030280 structural constituent of skin epidermis",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005856 cytoskeleton;GO:0045095 keratin filament",
        "go_biological_process": "GO:0030855 epithelial cell differentiation;GO:0045109 intermediate filament organization;GO:0002009 morphogenesis of an epithelium",
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        "protein_name": "Splicing factor C9orf78",
        "gene_name": "C9orf78",
        "organism": "Human",
        "refseq_name": "splicing factor C9orf78",
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            {
                "id": "NP_057604",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057604",
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        "gene_names_uniprotkb": "C9orf78; HCA59",
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        "protein_names_uniprotkb": "Splicing factor C9orf78; Hepatocellular carcinoma-associated antigen 59",
        "protein_names_refseq": "hepatocellular carcinoma-associated antigen 59; splicing factor C9orf78; telomere length and silencing protein 1 homolog; uncharacterized protein C9orf78",
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        "pathway": " (hsa:51759);  (R-HSA-72163)",
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        "publication_id_list": "10882114;11014198;11101529;11233976;11991638;12097419;12176931;12411573;12414731;12477934;14625303;14713954;15302935;15592455;16314458;16809785;17081983;17095540;17287340;17322306;17332742;17606899;17924679;18322460;18452278;18491316;18593880;18669648;18707149;18767875;19103666;19165350;19367720;19536130;19651622;19664995;19690332;19901323;20068231;20166139;20423332;20980672;21406692;21536652;2176635;22110043;22365833;22959432;22961380;23186163;23222130;23236153;23345524;24196718;24275569;24304693;24448447;24715725;24737827;24914973;25555158;25576301;2558966;26154972;26385511;26420826;26969736;26992070;27377154;27459055;27683217;27846572;27920218;28062851;28076346;28228285;28446606;28502770;28781166;28832583;29242379;29301961;29360106;29361316;29493099;29557506;29632711;2963332;30315277;30429286;30484775;30705154;30728453;30765414;30833945;30975767;31092671;31409651;31844290;31848261;32157095;32179686;32329775;32494006;32502341;32897882;32938616;32983136;33141586;33243851;33298915;33446560;33691108;33912179;33968037;34019948;34087483;34171305;34301950;34822310;35051231;35167828;35241646;35318648;35385551;35580925;36241641;36284347;3757028;8566756;8608946;9016565;9242493;9512519;9524131;9539711;9671485;9701291;9731529",
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        "function": "C9ORF78 partially localizes to centromeres and plays a role in chromosome segregation., [RefSeq, PubMed]; Plays a role in pre-mRNA splicing by promoting usage of the upstream 3'-splice site at alternative NAGNAG splice sites; these are sites featuring alternative acceptor motifs separated by only a few nucleotides (PubMed:35241646). May also modulate exon inclusion events (PubMed:35241646). Plays a role in spliceosomal remodeling by displacing WBP4 from SNRNP200 and may act to inhibit SNRNP200 helicase activity (PubMed:35241646). Binds U5 snRNA (PubMed:35241646). Required for proper chromosome segregation (PubMed:35167828). Not required for splicing of shelterin components (PubMed:35167828)., [UniProtKB, PubMed, PubMed]",
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        "go_molecular_function": "GO:0030623 U5 snRNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005681 spliceosomal complex;GO:0000775 chromosome, centromeric region",
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        "protein_name": "Zinc finger protein 592",
        "gene_name": "ZNF592",
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        "gene_names_refseq": "CAMOS; SCAR5; ZNF592",
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        "protein_names_refseq": "zinc finger protein 592",
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        "pathway": " (hsa:9640);  (R-HSA-9940951)",
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        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB, PubMed]; Plasma membrane protein SCARA5 can contribute to human hepatocellular carcinoma (HCC) tumorigenesis and metastasis via activation of the FAK signaling pathway., [RefSeq, PubMed]; This gene is thought to play a role in a complex developmental pathway and the regulation of genes involved in cerebellar development. Mutations in this gene have been associated with autosomal recessive spinocerebellar ataxia. [provided by RefSeq, Jan 2011]., [RefSeq]; ZNF592 is idenified as the gene responsible for Cerebellar Ataxia with Mental retardation, Optic atrophy and Skin abnormalities, a rare, nonprogressive, cerebellar ataxia syndrome., [RefSeq, PubMed]",
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        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding",
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        "protein_name": "Uncharacterized protein C20orf204",
        "gene_name": "C20orf204",
        "organism": "Human",
        "refseq_name": "uncharacterized protein C20orf204 precursor",
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            {
                "id": "NP_001335019",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001335019",
                "type": "external"
            }
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        "protein_names_uniprotkb": "Uncharacterized protein C20orf204",
        "protein_names_refseq": "long intergenic non-protein coding RNA 176; proline rich 17; putative proline-rich protein 17; uncharacterized protein C20orf204 precursor; uncharacterized protein C20orf204",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:284739)",
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        "function": "Knockdown of long non-coding RNA LINC00176 suppresses ovarian cancer progression by BCL3-mediated down-regulation of ceruloplasmin., [RefSeq, PubMed]; LINC00176 facilitates CD4(+)T cell adhesion in systemic lupus erythematosus via the WNT5a signaling pathway by regulating WIF1., [RefSeq, PubMed]; Study identified a novel long intergenic noncoding RNA, Linc00176, that plays a role in proliferation and survival of hepatocellular carcinoma., [RefSeq, PubMed]",
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        ],
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        "protein_name": "Probable non-functional immunoglobulin heavy variable 7-81",
        "gene_name": "IGHV7-81",
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        "record_id": "Q5HYJ3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5UCC4-1",
        "uniprot_id": [
            {
                "id": "EMC10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5UCC4",
                "type": "external"
            }
        ],
        "mass": 27347.0,
        "length": 262,
        "protein_name": "ER membrane protein complex subunit 10",
        "gene_name": "EMC10",
        "organism": "Human",
        "refseq_name": "ER membrane protein complex subunit 10 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_778233",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_778233",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EMC10; C19orf63; INM02; PRO1556",
        "gene_names_refseq": "C19orf63; EMC10; HSM1; HSS1; NEDDFAS",
        "protein_names_uniprotkb": "ER membrane protein complex subunit 10; Hematopoietic signal peptide-containing membrane domain-containing protein 1",
        "protein_names_refseq": "ER membrane protein complex subunit 10 isoform 1 precursor; UPF0510 protein INM02; hematopoietic signal peptide-containing membrane domain-containing 1; hematopoietic signal peptide-containing secreted 1",
        "tax_id": 9606,
        "disease": "neurodevelopmental disorder with dysmorphic facies and variable seizures (MONDO:MONDO:0031011)",
        "pathway": " (hsa:284361)",
        "pathway_count": 1,
        "publication_count": 67,
        "publication_id_list": "10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;11237011;12975309;15163304;19159218;19570817;20680400;22119785;24190977;25505266;25576301;25813380;26992070;27846572;27920218;28063628;28218747;28228285;28510447;28832583;28834231;28904123;28931551;29242231;29242379;29393594;29493099;29557506;29632046;29741879;29809151;30315122;30415835;30429286;30459171;30484775;31217245;31844290;32157095;32357974;32439656;32459176;32488085;32502341;32869858;32938616;32983136;33298915;33392160;33531666;33592498;33691108;33912179;34087483;34171305;34357683;34414886;35051231;35124540;35251023;35580925;35684946;36077468;36215666;36241641;36443308",
        "class_list": "",
        "function": "An engineered transcriptional reporter of protein localization identifies regulators of mitochondrial and ER membrane protein trafficking in high-throughput CRISPRi screens. Publication Status: Online-Only, [RefSeq, PubMed]; As a novel secreted protein, INM02 is associated with functions of pancreatic islets, especially of beta-cells, [RefSeq, PubMed]; Biallelic loss of EMC10 leads to mild to severe intellectual disability., [RefSeq, PubMed]; High-expression of hHSS1 is associated high-grade gliomas., [RefSeq, PubMed]; Membrane-Bound EMC10 Is Required for Sperm Motility via Maintaining the Homeostasis of Cytoplasm Sodium in Sperm. Publication Status: Online-Only, [RefSeq, PubMed]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable). Promotes angiogenesis and tissue repair in the heart after myocardial infarction. Stimulates cardiac endothelial cell migration and outgrowth via the activation of p38 MAPK, PAK and MAPK2 signaling pathways (PubMed:28931551)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Secreted EMC10 is upregulated in human obesity and its neutralizing antibody prevents diet-induced obesity in mice. Publication Status: Online-Only, [RefSeq, PubMed]; The phenotype of homozygous EMC10 variant: A new syndrome with intellectual disability and language impairment., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 8,
        "disease_count": 1,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5UCC6;Q69YT5;Q6UWP3;Q86YL4;Q8N541",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0072546 EMC complex;GO:0005576 extracellular region;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0010595 positive regulation of endothelial cell migration;GO:0045766 positive regulation of angiogenesis;GO:0001938 positive regulation of endothelial cell proliferation;GO:0071816 tail-anchored membrane protein insertion into ER membrane",
        "synthesized_glycan_count": 0,
        "hit_score": 8.1,
        "record_id": "Q5UCC4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NR12-1",
        "uniprot_id": [
            {
                "id": "PDLI7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NR12",
                "type": "external"
            }
        ],
        "mass": 49845.0,
        "length": 457,
        "protein_name": "PDZ and LIM domain protein 7",
        "gene_name": "PDLIM7",
        "organism": "Human",
        "refseq_name": "PDZ and LIM domain protein 7 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_005442",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005442",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PDLIM7; ENIGMA",
        "gene_names_refseq": "LMP1; LMP3; PDLIM7",
        "protein_names_uniprotkb": "PDZ and LIM domain protein 7; LIM mineralization protein; LMP; Protein enigma",
        "protein_names_refseq": "1110003B01Rik; LIM domain protein; LMP; Lim mineralization protein 3; PDZ and LIM domain 7 (enigma); PDZ and LIM domain protein 7 isoform 1; PDZ and LIM domain protein 7; protein enigma",
        "tax_id": 9606,
        "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); myofibrillar myopathy 4 (Disease Ontology:DOID:0080095); myopathy (Disease Ontology:DOID:423)",
        "pathway": " (hsa:9260);  (R-HSA-8853659)",
        "pathway_count": 2,
        "publication_count": 121,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10359609;10448070;10995764;11000521;11002419;11237011;11237712;11360177;11390647;11470823;11491658;11874232;11886862;12242309;12771945;14766744;15044950;15286081;15569713;16959974;17924679;18452278;18669648;20068230;20068231;21158410;22266808;22661428;23186163;23584533;24129315;25892735;26154972;26992070;27920218;28228285;28832583;28834231;29237092;29242379;29351928;29393594;29557506;29632046;29769354;30059200;30379171;30429286;31154438;31492838;31844290;31848261;32119511;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32574038;32870666;32938616;32938750;32983136;33043033;33214551;33298915;33592498;33912179;33968037;34019948;34087483;34405274;34725712;34846842;35051231;35132862;35138101;35154160;35251023;35254053;35289036;35318648;35513511;35580925;35896296;36010968;36241641;36284347;37222327;37340703;38132395;38243825;38665916;38838015;39302247;39531497;39534244;40136647;40596516;7665556;7929196;8628282;8631863;8637703;8662982;8663426;8674117;8940095;9047384;9192684;9299438;9407096;9491986;9528800;9764818;9883723",
        "class_list": "",
        "function": "Enigma of the cholesterol paradox in acute myocardial infarction: lessons from an 8-year follow-up of all-cause mortality in an age-matched and sex-matched case-control study with controls from the patients' recruitment area. Publication Status: Online-Only, [RefSeq, PubMed]; Epstein-Barr virus in gastric cancer and association with 30 bp del-latent membrane protein 1 polymorphism. Publication Status: Online-Only, [RefSeq, PubMed]; May function as a scaffold on which the coordinated assembly of proteins can occur. May play a role as an adapter that, via its PDZ domain, localizes LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Involved in both of the two fundamental mechanisms of bone formation, direct bone formation (e.g. embryonic flat bones mandible and cranium), and endochondral bone formation (e.g. embryonic long bone development). Plays a role during fracture repair. Involved in BMP6 signaling pathway (By similarity)., [UniProtKB, PubMed, PubMed]; PDLIM7 Promotes Tumor Metastasis in Papillary Thyroid Carcinoma via Stabilizing Focal Adhesion Kinase Protein., [RefSeq, PubMed]; Regulatory and Interacting Partners of PDLIM7 in Thyroid Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is representative of a family of proteins composed of conserved PDZ and LIM domains. LIM domains are proposed to function in protein-protein recognition in a variety of contexts including gene transcription and development and in cytoskeletal interaction. The LIM domains of this protein bind to protein kinases, whereas the PDZ domain binds to actin filaments. The gene product is involved in the assembly of an actin filament-associated complex essential for transmission of ret/ptc2 mitogenic signaling. The biological function is likely to be that of an adapter, with the PDZ domain localizing the LIM-binding proteins to actin filaments of both skeletal muscle and nonmuscle tissues. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 18,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 18,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 18,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 6,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 3,
        "glyco_site_count": 19,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q14250;Q5XG82;Q6NVZ5;Q96C91;Q9BXB8;Q9BXB9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0051371 muscle alpha-actinin binding;GO:0003779 actin binding;GO:0046872 metal ion binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005912 adherens junction;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton;GO:0001725 stress fiber",
        "go_biological_process": "GO:0007507 heart development;GO:0030154 cell differentiation;GO:0030036 actin cytoskeleton organization;GO:0006898 receptor-mediated endocytosis;GO:0001503 ossification",
        "synthesized_glycan_count": 0,
        "hit_score": 14.5,
        "record_id": "Q9NR12-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q4G0M1-1",
        "uniprot_id": [
            {
                "id": "ERFE_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q4G0M1",
                "type": "external"
            }
        ],
        "mass": 37279.0,
        "length": 354,
        "protein_name": "Erythroferrone",
        "gene_name": "ERFE",
        "organism": "Human",
        "refseq_name": "erythroferrone precursor",
        "refseq_ac": [
            {
                "id": "NP_001278761",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001278761",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ERFE; C1QTNF15; CTRP15; FAM132B",
        "gene_names_refseq": "C1QTNF15; CTRP15; ERFE; FAM132B",
        "protein_names_uniprotkb": "Erythroferrone; Complement C1q tumor necrosis factor-related protein 15; Myonectin",
        "protein_names_refseq": "complement C1q tumor necrosis factor-related protein 15; erythroferrone precursor; family with sequence similarity 132, member B; myonectin; protein FAM132B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:151176)",
        "pathway_count": 1,
        "publication_count": 23,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;11237011;22351773;23584533;24880340;26978524;29557506;30097509;30833945;31154438;31800957;32157095;32983136;33968037;35051231;35251023;35700181;36215666;36675239;37253412;37866631;37949218",
        "class_list": "",
        "function": "Characterization of erythroferrone oligomerization and its impact on BMP antagonism., [RefSeq, PubMed]; Characterization of erythroferrone structural domains relevant to its iron-regulatory function., [RefSeq, PubMed]; In Silico Pan-Cancer Analysis Reveals Prognostic Role of the Erythroferrone (ERFE) Gene in Human Malignancies. Publication Status: Online-Only, [RefSeq, PubMed]; In hemodialysis patients DA and CERA increased levels of ERFE that regulated hepcidin 25 and led to iron mobilization from body stores during erythropoiesis. Publication Status: Online-Only, [RefSeq, PubMed]; Iron-regulatory hormone that acts as an erythroid regulator after hemorrhage: produced by erythroblasts following blood loss and mediates suppression of hepcidin (HAMP) expression in the liver, thereby promoting increased iron absorption and mobilization from stores (PubMed:24880340, PubMed:30097509, PubMed:31800957). Promotes lipid uptake into adipocytes and hepatocytes via transcriptional up-regulation of genes involved in fatty acid uptake (By similarity). Inhibits apoptosis and inflammatory response in cardiomyocytes via promotion of sphingosine-1-phosphate (S1P) and cAMP-dependent activation of AKT signaling (By similarity). Inhibits autophagy induced by nutrient deficiency in hepatocytes via promoting the phosphorylation of IRS1, AKT, and MTOR, and thereby subsequent activation of the AKT-MTOR signaling pathway (By similarity). Negatively regulates the differentiation of osteoblasts, potentially via sequestering BMP2, and thereby inhibits the activation of SMAD signaling (By similarity). The reduction in BMP2 signaling in osteoblasts also results in an increase in expression of the osteoclastogenesis-promoting factors TNFSF11/RANKL and SOST, thereby indirectly promotes bone resorption (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Myonectin links skeletal muscle to lipid homeostasis in liver and adipose tissue in response to alterations in energy state, revealing a novel myonectin-mediated metabolic circuit., [RefSeq, PubMed]; Placental Erythroferrone and Erythropoietin mRNA Expression is not Associated with Maternal or Neonatal Iron Status in Adolescents Carrying Singletons and Adult Women Carrying Multiples., [RefSeq, PubMed]; Plasma Complement C1q/tumor necrosis factor-related protein 15 concentration is associated with polycystic ovary syndrome. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "W8S2M9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0005179 hormone activity;GO:0140313 molecular sequestering activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0043066 negative regulation of apoptotic process;GO:0051897 positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction;GO:0006879 intracellular iron ion homeostasis;GO:0010507 negative regulation of autophagy;GO:0030514 negative regulation of BMP signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "Q4G0M1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IUH3-1",
        "uniprot_id": [
            {
                "id": "RBM45_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IUH3",
                "type": "external"
            }
        ],
        "mass": 53502.0,
        "length": 476,
        "protein_name": "RNA-binding protein 45",
        "gene_name": "RBM45",
        "organism": "Human",
        "refseq_name": "RNA-binding protein 45 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_694453",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_694453",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RBM45; DRB1; DRBP1",
        "gene_names_refseq": "DRB1; RB-1; RBM45",
        "protein_names_uniprotkb": "RNA-binding protein 45; Developmentally-regulated RNA-binding protein 1; RB-1; RNA-binding motif protein 45",
        "protein_names_refseq": "RNA-binding protein 45 isoform 1; RNA-binding protein 45; developmentally regulated RNA-binding protein 1; putative RNA binding protein RB-1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:129831)",
        "pathway_count": 1,
        "publication_count": 38,
        "publication_id_list": "11237011;12220514;22993125;23186163;24714562;24715725;25418920;25576301;25892735;26154972;26728094;26929215;26992070;27862975;28218747;28832583;28855257;28904123;29557506;29769354;29786170;30379171;30429286;31217245;31844290;32157095;32357974;32983136;33298915;33717175;33912179;33968037;34019948;34118419;35051231;36435031;36581221;38040804",
        "class_list": "",
        "function": "A new member of RRM-type neural RNA-binding protein, [RefSeq, PubMed]; Family-based exome sequencing identifies RBM45 as a possible candidate gene for frontotemporal dementia and amyotrophic lateral sclerosis., [RefSeq, PubMed]; Molecular basis of ssDNA recognition by RBM45 protein of neurodegenerative disease from multiple molecular dynamics simulations and energy predictions., [RefSeq, PubMed]; RBM45 reprograms lipid metabolism promoting hepatocellular carcinoma via Rictor and ACSL1/ACSL4., [RefSeq, PubMed]; RNA-binding protein with binding specificity for poly(C). May play an important role in neural development., [UniProtKB, UniProtKB, PubMed]; This gene encodes a member of the RNA recognition motif (RRM)-type RNA-binding family of proteins. This protein exhibits preferential binding to poly(C) RNA. Initial cloning of this gene found that the rat ortholog was dynamically expressed in the developing rat brain. This protein has been localized to inclusion bodies in the brain and spinal cord of amyotrophic lateral sclerosis and Alzheimer's patients. A pseudogene has been identified on chromosome 8. [provided by RefSeq, Feb 2015]., [RefSeq]; This study demonistrated that RBM45 protein accumulates in inclusion bodies in amyotrophic lateral sclerosis (ALS) and frontotemporal lobar degeneration with TDP-43 inclusions (FTLD-TDP) patients., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6NYL0;Q8NFC9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 4.1,
        "record_id": "Q8IUH3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P55899-1",
        "uniprot_id": [
            {
                "id": "FCGRN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P55899",
                "type": "external"
            }
        ],
        "mass": 39743.0,
        "length": 365,
        "protein_name": "IgG receptor FcRn large subunit p51",
        "gene_name": "FCGRT",
        "organism": "Human",
        "refseq_name": "IgG receptor FcRn large subunit p51 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001129491",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129491",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FCGRT; FCRN",
        "gene_names_refseq": "FCGRT; FCRN; FcgammaRn; alpha-chain",
        "protein_names_uniprotkb": "IgG receptor FcRn large subunit p51; FcRn; IgG Fc fragment receptor transporter alpha chain; Neonatal Fc receptor",
        "protein_names_refseq": "Fc fragment of IgG receptor and transporter; Fc fragment of IgG, receptor, transporter, alpha; FcRn alpha chain; IgG Fc fragment receptor transporter alpha chain; IgG receptor FcRn large subunit p51 isoform 1 precursor; IgG receptor FcRn large subunit p51; heavy chain of the major histocompatibility complex class I-like Fc receptor; immunoglobulin receptor, intestinal, heavy chain; major histocompatibility complex class I-like Fc receptor; neonatal Fc receptor; neonatal Fc-receptor for Ig; neonatal fragment crystallizable Fc receptor FcRn; transmembrane alpha chain of the neonatal receptor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2217)",
        "pathway_count": 1,
        "publication_count": 48,
        "publication_id_list": "10.1101/2023.09.13.557529;10933786;10998088;11237011;12578848;15340161;24190977;24275569;24469444;25548167;25576301;26992070;27452731;27920218;28330995;28560793;29242379;29557506;29632711;29741879;29786170;29789417;30459171;30808762;31104841;32157095;32350084;32387766;32938616;32983136;33091337;33123756;33298915;33392160;33912179;33968037;34357683;34509645;35051231;35154160;35251023;35580925;37074911;37938771;38353127;38971109;39266307;7964511",
        "class_list": "",
        "function": "(Microbial infection) Acts as an uncoating receptor for a panel of echoviruses including Echovirus 5, 6, 7, 9, 11, 13, 25 and 29., [UniProtKB, PubMed, PubMed]; Albumin influences leucocyte FcRn expression in the early days of kidney transplantation., [RefSeq, PubMed]; Cell surface receptor that transfers passive humoral immunity from the mother to the newborn. Binds to the Fc region of monomeric immunoglobulin gamma and mediates its selective uptake from milk (PubMed:10933786, PubMed:7964511). IgG in the milk is bound at the apical surface of the intestinal epithelium. The resultant FcRn-IgG complexes are transcytosed across the intestinal epithelium and IgG is released from FcRn into blood or tissue fluids. Throughout life, contributes to effective humoral immunity by recycling IgG and extending its half-life in the circulation. Mechanistically, monomeric IgG binding to FcRn in acidic endosomes of endothelial and hematopoietic cells recycles IgG to the cell surface where it is released into the circulation (PubMed:10998088). In addition of IgG, regulates homeostasis of the other most abundant circulating protein albumin/ALB (PubMed:24469444, PubMed:28330995)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, UniProtKB, UniProtKB]; Neonatal Fc receptor is a functional receptor for classical human astrovirus., [RefSeq, PubMed]; The role of immunoglobulin transport receptor, neonatal Fc receptor in mucosal infection and immunity and therapeutic intervention. Review article, [RefSeq, PubMed]; This gene encodes a receptor that binds the Fc region of monomeric immunoglobulin G. The encoded protein transfers immunoglobulin G antibodies from mother to fetus across the placenta. This protein also binds immunoglobulin G to protect the antibody from degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 8836,
        "biomarker_type": "",
        "glycan_count": 49,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5HYM5;Q9HBV7;Q9NZ19",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030881 beta-2-microglobulin binding;GO:0019864 IgG binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0009897 external side of plasma membrane;GO:0010008 endosome membrane;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006955 immune response;GO:0002416 IgG immunoglobulin transcytosis in epithelial cells mediated by FcRn immunoglobulin receptor",
        "synthesized_glycan_count": 0,
        "hit_score": 10.0,
        "record_id": "P55899-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96L91-1",
        "uniprot_id": [
            {
                "id": "EP400_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96L91",
                "type": "external"
            }
        ],
        "mass": 343489.0,
        "length": 3159,
        "protein_name": "E1A-binding protein p400",
        "gene_name": "EP400",
        "organism": "Human",
        "refseq_name": "E1A-binding protein p400",
        "refseq_ac": [
            {
                "id": "NP_056224",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056224",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EP400; CAGH32; KIAA1498; KIAA1818; TNRC12",
        "gene_names_refseq": "CAGH32; EP400; P400; TNRC12",
        "protein_names_uniprotkb": "E1A-binding protein p400; 3.6.4.-; CAG repeat protein 32; Domino homolog; Trinucleotide repeat-containing gene 12 protein; hDomino; p400 kDa SWI2/SNF2-related protein",
        "protein_names_refseq": "CAG repeat protein 32; E1A-binding protein p400; domino homolog; hDomino(p400); hDomino; p400 SWI2/SNF2-related protein; p400 kDa SWI2/SNF2-related protein; trinucleotide repeat containing 12; trinucleotide repeat-containing gene 12 protein",
        "tax_id": 9606,
        "disease": "syndromic intellectual disability (Disease Ontology:DOID:0050888); developmental disorder of mental health (Disease Ontology:DOID:0060037)",
        "pathway": " (hsa:57634);  (R-HSA-2559584);  (R-HSA-2559586);  (R-HSA-3214847)",
        "pathway_count": 4,
        "publication_count": 180,
        "publication_id_list": "10.1074/mcp.M114.046862;10.1101/2023.09.13.557529;10037601;10323868;10669743;10786633;10821277;11237011;11454856;11509179;12393752;12556884;12963728;14532133;14966270;15064416;15196461;15313887;15369670;15458641;15510216;15621527;15655109;15790808;16141325;16166375;16262255;16387653;16858402;16901784;17081983;17158953;17242198;17242207;17694070;17923702;18381289;18413597;18438399;18623064;18669648;19029251;19187765;19608861;19783983;20018852;20068231;21320693;21406692;21807893;22424782;22661428;23186163;23301498;2342578;23481700;2392154;23964094;24275569;24366607;24463511;24714562;24715725;25240135;25418920;25576301;25645385;25813380;25892735;26154972;26375851;26728094;26811146;26929215;26992070;27600516;27655845;27846572;27920218;28218747;28228285;28314751;28657654;28832583;28834231;28904123;29237092;29242379;29351928;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29786170;30059200;30315122;30379171;30410026;30429286;30524438;30620550;30779550;30833945;31092671;31154438;31217245;31492838;31637018;31844290;31848261;31998317;32157095;32161166;32265295;32350084;32357974;32387766;32488085;32502341;32574038;32897882;32938616;32938750;32983136;33141586;33214551;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33968037;33981976;34019948;34171305;34185709;34211107;34509645;34561969;34725712;34846842;34932366;35051231;35132862;35138101;35254053;35289036;35318648;35513511;35561310;35580925;35705054;36010968;36241641;36284347;37340703;37541260;38665916;38838015;39302247;39531497;39534244;40307207;40596516;41350704;8242751;8242752;9225980;9427644;9558366;9733514;9733515;9843217;9880483",
        "class_list": "",
        "function": "Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. May be required for transcriptional activation of E2F1 and MYC target genes during cellular proliferation. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42 transcription activity. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AZ1 from the nucleosome., [UniProtKB, PubMed, PubMed]; P400 is a component of the p53-p21(WAF1/CIP1/sid1) pathway, regulating the p21 transcription and cell senescence induction program., [RefSeq, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 5,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 61,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 61,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 61,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 15,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 24,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 4,
        "disease_count": 2,
        "glyco_site_count": 67,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15411;Q6P2F5;Q8N8Q7;Q8NE05;Q96JK7;Q9P230",
        "ec_number_list": [
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:1990405 protein antigen binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0016607 nuclear speck;GO:0035267 NuA4 histone acetyltransferase complex;GO:0000812 Swr1 complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0006281 DNA repair;GO:0007399 nervous system development;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization;GO:0042981 regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 24.7,
        "record_id": "Q96L91-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.001000.000000000001000000.1100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q96EB1-1",
        "uniprot_id": [
            {
                "id": "ELP4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96EB1",
                "type": "external"
            }
        ],
        "mass": 46588.0,
        "length": 424,
        "protein_name": "Elongator complex protein 4",
        "gene_name": "ELP4",
        "organism": "Human",
        "refseq_name": "elongator complex protein 4 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001275654",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001275654",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ELP4; C11orf19; PAXNEB",
        "gene_names_refseq": "AN2; AN; C11orf19; ELP4; PAX6NEB; PAXNEB; dJ68P15A.1; hELP4",
        "protein_names_uniprotkb": "Elongator complex protein 4; PAX6 neighbor gene protein; hELP4",
        "protein_names_refseq": "PAX6 neighbor gene protein; elongation protein 4 homolog; elongator complex protein 4 isoform 2; elongator complex protein 4",
        "tax_id": 9606,
        "disease": "aniridia (Disease Ontology:DOID:12271); aniridia 2 (MONDO:MONDO:0014937)",
        "pathway": " (hsa:26610);  (R-HSA-3214847)",
        "pathway_count": 2,
        "publication_count": 86,
        "publication_id_list": "10.1101/2023.09.13.557529;10786633;10821277;11230166;11237011;11714725;11818576;11889558;15313887;16387653;16713582;17924679;18381289;18623064;19187765;20018852;22854966;23481700;24290376;24714562;24715725;25418920;25576301;25645385;25892735;26010655;26375851;26728094;26992070;27846572;27862975;27920218;28904123;29242379;29332244;29393594;29493099;29557506;29632046;29805303;30379171;30429286;30620550;30833945;31154438;31217245;31222486;31530632;31743616;31844290;31848261;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33537174;33592498;33717175;33936100;33968037;34087483;34171305;34211107;34357683;34509645;34725712;35051231;35254053;35318648;35513511;35561310;35580925;36010968;36215666;36241641;36284347;37938771;9427644;9558366;9880483",
        "class_list": "",
        "function": "Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; ELP4 rs986527 polymorphism affected the incidence of clinical symptoms and the levels of TNF-alpha and IL-1beta in patients with intracranial Arachnoid Cysts., [RefSeq, PubMed]; Elongator activated migration and invasion of hepatocellular carcinoma cells by promoting the expression of MMP-2 and MMP-9 through the PI3K/AKT signaling pathway Publication Status: Online-Only, [RefSeq, PubMed]; Our results suggest that ELP4 deletions are highly likely to be pathogenic, predisposing to a range of neurodevelopmental phenotypes from ASD to language impairment and epilepsy., [RefSeq, PubMed]; This gene encodes a component of the six subunit elongator complex, a histone acetyltransferase complex that associates directly with RNA polymerase II during transcriptional elongation. The human gene can partially complement sensitivity phenotypes of yeast ELP4 deletion mutants. This gene has also been associated with Rolandic epilepsy. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E3W0;E7EPZ6;Q9H4E8;Q9NX11",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0008023 transcription elongation factor complex;GO:0033588 elongator holoenzyme complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006417 regulation of translation;GO:0002098 tRNA wobble uridine modification",
        "synthesized_glycan_count": 0,
        "hit_score": 9.2,
        "record_id": "Q96EB1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6P179-1",
        "uniprot_id": [
            {
                "id": "ERAP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P179",
                "type": "external"
            }
        ],
        "mass": 110462.0,
        "length": 960,
        "protein_name": "Endoplasmic reticulum aminopeptidase 2",
        "gene_name": "ERAP2",
        "organism": "Human",
        "refseq_name": "endoplasmic reticulum aminopeptidase 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001123612",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001123612",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ERAP2; LRAP",
        "gene_names_refseq": "ERAP2; L-RAP; LRAP",
        "protein_names_uniprotkb": "Endoplasmic reticulum aminopeptidase 2; 3.4.11.-; L-RAP; Leukocyte-derived arginine aminopeptidase",
        "protein_names_refseq": "endoplasmic reticulum aminopeptidase 2 isoform 1; leukocyte-derived arginine aminopeptidase",
        "tax_id": 9606,
        "disease": "severe pre-eclampsia (Disease Ontology:DOID:13129)",
        "pathway": " (hsa:64167);  (R-HSA-983170)",
        "pathway_count": 2,
        "publication_count": 117,
        "publication_id_list": "10.1101/2023.09.13.557529;10064069;10600378;10777614;10825291;10982397;11160214;11163199;11237011;11514579;12436109;12436110;12645939;12799365;14681859;14718384;15286279;15691326;15908954;15927284;16286653;16335952;16465444;16473882;16585582;17056546;17088086;17316621;17332242;17656363;19119025;19193869;19261456;19342655;19361863;19426129;19575639;19851281;2038058;20605430;21050182;22106953;23090970;24190977;24366607;2450918;24715725;25418920;25880248;25892735;26375851;26811146;26992070;27397612;27452731;27846572;27920218;28218747;28228285;28489076;28832583;28904123;29242379;29391424;29437277;29493099;29508533;29557506;29741879;29769354;29786170;30315122;30410026;30429286;30524438;30573663;30779550;31217245;31530632;31844290;31848261;32157095;32350084;32357974;32488085;32897882;32938616;32983136;33091337;33298915;33592498;33633747;33717175;33912179;33936100;33968037;34019948;34185709;34357683;34932366;35051231;35154160;35251023;35580925;36241641;36284347;36581221;37074911;37686141;38190099;38704785;39123229;40914422;7642652;7876241;8342042;9605141",
        "class_list": "",
        "function": "A cis-regulatory element regulates ERAP2 expression through autoimmune disease risk SNPs., [RefSeq, PubMed]; A study of the association between single nucleotide polymorphisms of the endoplasmic reticulum aminopeptidase 2 (ERAP2) gene and the risk of ankylosing spondylitis in Egyptians. Publication Status: Online-Only, [RefSeq, PubMed]; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Preferentially hydrolyzes the basic residues Arg and Lys., [UniProtKB, PubMed, PubMed, PubMed]; ERAP1 and ERAP2 Haplotypes Influence Suboptimal HLA-B*27:05-Restricted Anti-Viral CD8+ T Cell Responses Cross-Reactive to Self-Epitopes. Publication Status: Online-Only, [RefSeq, PubMed]; The effect of rs2910686 on ERAP2 expression in IBD and epithelial inflammatory response. Erratum:[J Transl Med. 2024 Sep 20;22(1):849. doi: 10.1186/s12967-024-05645-2. PMID: 39304925] Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a zinc metalloaminopeptidase of the M1 protease family that resides in the endoplasmic reticulum and functions in N-terminal trimming antigenic epitopes for presentation by major histocompatibility complex (MHC) class I molecules. Certain mutations in this gene are associated with the inflammatory arthritis syndrome ankylosing spondylitis and pre-eclampsia. This gene is located adjacent to a closely related aminopeptidase gene on chromosome 5. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 10,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 8,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 11,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 11,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 4,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 37,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 46,
        "disease_count": 1,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z5K1;Q8TD32;Q8WVJ4;Q9HBX2",
        "ec_number_list": [
            {
                "id": "3.4.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0008237 metallopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0070006 metalloaminopeptidase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005789 endoplasmic reticulum membrane;GO:0005737 cytoplasm;GO:0012505 endomembrane system",
        "go_biological_process": "GO:0006508 proteolysis;GO:0008217 regulation of blood pressure;GO:0043171 peptide catabolic process;GO:0002474 antigen processing and presentation of peptide antigen via MHC class I;GO:0002250 adaptive immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 17.6,
        "record_id": "Q6P179-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IYD8-1",
        "uniprot_id": [
            {
                "id": "FANCM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IYD8",
                "type": "external"
            }
        ],
        "mass": 232191.0,
        "length": 2048,
        "protein_name": "Fanconi anemia group M protein",
        "gene_name": "FANCM",
        "organism": "Human",
        "refseq_name": "Fanconi anemia group M protein isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001295062",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001295062",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FANCM; KIAA1596",
        "gene_names_refseq": "FAAP250; FANCM; KIAA1596; POF15; SPGF28",
        "protein_names_uniprotkb": "Fanconi anemia group M protein; 3.6.4.13; ATP-dependent RNA helicase FANCM; FAAP250; Fanconi anemia-associated polypeptide of 250 kDa; Protein FACM; Protein Hef ortholog",
        "protein_names_refseq": "ATP-dependent RNA helicase FANCM; Fanconi anemia complementation group M; Fanconi anemia group M protein isoform 2; fanconi anemia group M protein; fanconi anemia-associated polypeptide of 250 kDa; protein Hef ortholog",
        "tax_id": 9606,
        "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); primary ovarian insufficiency 15 (Disease Ontology:DOID:0080872); spermatogenic failure 28 (Disease Ontology:DOID:0111916); Fanconi anemia (Disease Ontology:DOID:13636)",
        "pathway": " (hsa:57697);  (R-HSA-6783310);  (R-HSA-9833482)",
        "pathway_count": 3,
        "publication_count": 242,
        "publication_id_list": "10.1101/2023.09.13.557529;10082513;10348343;10400669;10620360;10626894;10648614;10848580;10866685;11096080;11134010;11152499;11156368;11237011;11238103;11238927;11239454;11278865;11313968;11337501;11350938;11438540;11500375;11781817;11909525;11939789;11985496;12231563;12397061;12882984;1373135;14585331;15229216;15299030;15572677;15737233;15752359;15907845;16116422;16116434;16179258;16179259;16373505;16431927;16600570;16717090;16916645;16943440;1695551;16982605;17079286;17196820;17289582;17412408;17460694;17938197;18082604;18096616;18174376;18452278;18835251;18931676;18957415;19111657;19229320;19413330;19416861;19423727;19561358;19589784;19596236;19615748;19710021;19733181;19804757;19838063;19995904;20102227;20347428;20347429;20385554;20395957;20519500;20603015;20603016;20603073;20670894;20671156;20685959;21072047;21123651;21294215;21464321;21518807;21636578;21701511;21764741;21937648;21978664;21994559;22214662;22258451;22287633;22396592;2247437;22510687;22692201;22986343;23084476;23186163;23229543;23325218;23481700;23698467;23723247;23732991;24076221;24347309;24389026;24623135;24623813;24659800;24714562;24715725;24726325;24753571;24905007;25418920;25430771;25500724;25576301;25645385;25653431;25848059;26154972;26432638;26446704;26488609;26716879;26728094;26817845;26992070;27208315;27269119;27423063;27846572;27974558;28069888;28167698;28218747;28228285;28281686;28765891;28832583;28904123;29170442;29175459;29231267;29231814;29242379;29348664;29351928;29393594;29394925;29395325;29440070;29493099;29501855;29508533;29557506;29632046;29789417;29895858;30075111;30174290;30315122;30379171;30770398;30779550;30833945;31031002;31154438;31217245;31844290;32093270;32157095;32161166;32357974;32387766;32488085;32502341;32716602;32801355;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33808629;33911136;33912179;33968037;34171305;34174402;34211107;34932366;34974812;35051231;35685460;35802266;35947956;36010968;36215666;36241641;36707629;36712380;37127961;37938771;39189453;7491766;7515177;7545299;7565688;7693978;7737357;7903669;8576172;8576179;8661426;8810342;8910500;9034343;9079663;9442054;9521856;9528799;9687506;9737981;9819388;9920933",
        "class_list": "",
        "function": "DNA-dependent ATPase component of the Fanconi anemia (FA) core complex (PubMed:16116422). Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage (PubMed:16116422, PubMed:19423727, PubMed:20347428, PubMed:20347429, PubMed:29231814). In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates (PubMed:20347428, PubMed:20347429). Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX (PubMed:20347429). In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates (PubMed:17289582). In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA (PubMed:16116434)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; DNA-dependent ATPase component of the Fanconi anemia (FA) core complex. Required for the normal activation of the FA pathway, leading to monoubiquitination of the FANCI-FANCD2 complex in response to DNA damage, cellular resistance to DNA cross-linking drugs, and prevention of chromosomal breakage. In complex with CENPS and CENPX, binds double-stranded DNA (dsDNA), fork-structured DNA (fsDNA) and Holliday junction substrates. Its ATP-dependent DNA branch migration activity can process branched DNA structures such as a movable replication fork. This activity is strongly stimulated in the presence of CENPS and CENPX. In complex with FAAP24, efficiently binds to single-strand DNA (ssDNA), splayed-arm DNA, and 3'-flap substrates. In vitro, on its own, strongly binds ssDNA oligomers and weakly fsDNA, but does not bind to dsDNA., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; FANCM is an anchor required for recruitment of the FA core complex to chromatin, and the FANCM/FAAP24 interaction is essential for this chromatin-loading activity, [RefSeq, PubMed]; FANCM missense variants and breast cancer risk: a case-control association study of 75,156 European women., [RefSeq, PubMed]; Mechanism of structure-specific DNA binding by the FANCM branchpoint translocase., [RefSeq, PubMed]; Prevalence of FANCM germline variants in BRCA1/2 negative breast and/or ovarian cancer patients from Pakistan., [RefSeq, PubMed]; The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group M. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2015]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 76,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 4,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RTQ9;Q3YFH9;Q8N9X6;Q9HCH6",
        "ec_number_list": [
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
            },
            {
                "id": "4.2.99.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.99.18",
                "type": "external"
            },
            {
                "id": "5.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.1.6",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "3.6.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.12",
                "type": "external"
            },
            {
                "id": "3.4.21.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.53",
                "type": "external"
            },
            {
                "id": "5.6.2.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.5",
                "type": "external"
            },
            {
                "id": "3.1.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.-.-",
                "type": "external"
            },
            {
                "id": "3.5.4.37",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.4.37",
                "type": "external"
            },
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "7.2.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.2.2.-",
                "type": "external"
            },
            {
                "id": "5.6.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.-",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "3.5.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.2.6",
                "type": "external"
            },
            {
                "id": "3.6.1.15",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.15",
                "type": "external"
            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
                "type": "external"
            },
            {
                "id": "3.1.22.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.22.-",
                "type": "external"
            },
            {
                "id": "3.4.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.-",
                "type": "external"
            },
            {
                "id": "3.1.13.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.1",
                "type": "external"
            },
            {
                "id": "5.6.2.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.6",
                "type": "external"
            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
                "type": "external"
            },
            {
                "id": "2.3.2.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.23",
                "type": "external"
            },
            {
                "id": "1.3.1.91",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.91",
                "type": "external"
            },
            {
                "id": "2.7.1.91",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.91",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.1.21.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.21.-",
                "type": "external"
            },
            {
                "id": "3.1.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1",
                "type": "external"
            },
            {
                "id": "2.7.4.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.3",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0043138 3'-5' DNA helicase activity;GO:0003682 chromatin binding;GO:0005524 ATP binding;GO:0016887 ATP hydrolysis activity;GO:0000400 four-way junction DNA binding",
        "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0071821 FANCM-MHF complex;GO:0005654 nucleoplasm;GO:0005829 cytosol;GO:0000785 chromatin",
        "go_biological_process": "GO:0000712 resolution of meiotic recombination intermediates;GO:0036297 interstrand cross-link repair;GO:0031297 replication fork processing;GO:1902527 positive regulation of protein monoubiquitination;GO:0045003 double-strand break repair via synthesis-dependent strand annealing",
        "synthesized_glycan_count": 0,
        "hit_score": 25.0,
        "record_id": "Q8IYD8-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P01857-2",
        "uniprot_id": [
            {
                "id": "IGHG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P01857",
                "type": "external"
            }
        ],
        "mass": 43912.0,
        "length": 399,
        "protein_name": "Immunoglobulin heavy constant gamma 1",
        "gene_name": "IGHG1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "IGHG1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Immunoglobulin heavy constant gamma 1; Ig gamma-1 chain C region EU; Ig gamma-1 chain C region KOL; Ig gamma-1 chain C region NIE; Ig gamma-1 chain C region",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "multiple myeloma (Disease Ontology:DOID:9538)",
        "pathway": " (R-HSA-166663);  (R-HSA-173623);  (R-HSA-2029481);  (R-HSA-2029482);  (R-HSA-2029485);  (R-HSA-6785807);  (R-HSA-9664323);  (R-HSA-9664422);  (R-HSA-977606)",
        "pathway_count": 9,
        "publication_count": 324,
        "publication_id_list": "10.1007/s00018-021-03863-1;10.1101/2023.09.13.557529;1002129;10023775;10219243;10219247;10224668;10369418;10496324;10510379;10531307;10559936;10574203;10579907;10586089;1067618;10724160;10781580;10818239;10861086;10867011;10878810;10917521;10925294;10995437;11058569;11084045;11104795;11120780;11157975;11231582;11276226;11278437;11278486;11278729;11329366;11340081;11340299;11356008;11404481;11406581;11425868;11463377;11553796;11694537;11711607;11747816;11749377;11804587;11829459;11854399;11939578;11960372;11972529;12055245;12055636;12105426;12117970;12189515;12213210;12223527;12235133;12242343;12396008;12417718;12427744;1249422;12600988;12652077;12660731;12743368;12832402;12869549;1314888;1372004;1386357;14280442;14634100;14676198;14712222;15040784;15116091;15161916;15199963;15261459;15294978;15452139;15536084;15572068;15584925;15657136;15805299;15809313;15869882;15879134;15950906;16007214;16048438;16079145;16107692;16192651;16205632;16219319;16236134;16262445;16397018;1639758;16451196;16497229;16510571;16540365;16546099;16606674;16641196;16678913;16702231;16880808;16921024;16999828;17182573;17188549;17202194;17308335;17427945;17458857;17505110;17572495;17576170;17590538;18070890;18243101;18353781;18391171;18420934;18447642;18514042;18644974;18818202;19124156;19139490;19159218;19185846;19358553;19397496;19741094;19955216;20176268;2026457;20357243;20493732;21037092;21102457;21252155;2138613;21419341;21609021;21689689;21730069;21768335;21788512;21937440;21994466;22046235;22158414;22184099;22205702;22383755;22693070;22802338;22851691;23086340;23124025;23172665;23382691;23455323;23487775;23555662;2363690;23675550;23865566;23944609;23967200;24097101;24190977;2420889;24530628;2465906;2466593;24680513;24743777;2474607;24766575;2481448;24841998;25004930;25234944;2529342;25345863;25561553;25685702;25733881;26140596;28566370;29133956;293688;293746;29445378;2956252;29671580;2971659;29741879;29992770;30061887;301546;30237853;30397120;30659065;31467031;32125861;33563762;34089345;34725484;34834161;3567160;36529104;36581221;3661998;36867679;37217939;37421619;38383719;3848661;38665916;39983994;4098172;4923144;5489771;5530842;6019133;6214588;6219696;6222381;6230668;6238120;6287432;6334079;6454142;6607952;670886;6811139;6884994;6906228;702059;70787;7236608;7391570;7391573;7510216;7512451;7512959;7516890;7517665;7521687;7522622;7529288;7530449;7540366;7542572;760802;761607;7690834;7691959;7718892;7795521;7796300;7848918;7898939;7907877;8085155;814163;8226994;8228618;826475;8327478;8340414;8345200;8495193;8538770;8541526;8602263;8611682;8621622;8657103;8663118;8668165;8786315;8797861;8809042;8816495;8862523;8870235;8943038;8986718;9000504;9013879;9038722;9042338;9050880;9162098;9314552;9600938;9651359;9705280;9723655;9736340;978134;9799231;9822675;9843499;9857068;9874564;9883880;9885284;9973503",
        "class_list": "",
        "function": "Constant region of immunoglobulin (Ig) heavy chains. Igs are membrane-bound or secreted glycoproteins produced by B lymphocytes. In the recognition phase of humoral immunity, the membrane-bound Igs serve as receptors, which upon binding to a specific antigen trigger the clonal expansion and differentiation of B lymphocytes into Ig-secreting plasma cells. Secreted Igs known as antibodies mediate the effector phase of humoral immunity by blocking the interaction of infectious antigens with cellular receptors (via the antigen-binding region) and eliciting effector mechanisms that lead to pathogen neutralization (via the constant region) (PubMed:17576170, PubMed:20176268, PubMed:22158414). The antigen-binding region is formed by the variable domain of one heavy chain paired with the variable domain of its associated light chain. Each Ig molecule has two antigen-binding sites with remarkable affinity for a particular antigen due to V-(D)-J rearrangement, somatic hypermutations and affinity maturation of the variable domains upon antigen exposure (PubMed:17576170, PubMed:20176268, PubMed:22158414). The constant region defines the Ig isotype that perform distinct sets of effector functions. B cells diversify and rearrange their Ig constant regions through class-switch recombination, a process by which the constant region is switched from one Ig isotype to another, namely from IgM and IgD to IgG, IgA and IgE (PubMed:17576170, PubMed:20176268, PubMed:22158414). The constant region of Ig gamma-1 (IgG1) isotype interacts (via the fragment crystallizable, Fc) with receptors on innate immune cells and the complement system to mediate humoral effector functions, including antibody-dependent cellular cytotoxicity or phagocytosis, complement-dependent cytotoxicity and inflammatory responses., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 55,
        "reported_phosphosites": 0,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 221,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A0A0MS08",
        "ec_number_list": [],
        "go_molecular_function": "GO:0034987 immunoglobulin receptor binding;GO:0034988 Fc-gamma receptor I complex binding;GO:0003823 antigen binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0072562 blood microparticle",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0002250 adaptive immune response;GO:0050853 B cell receptor signaling pathway;GO:0097278 complement-dependent cytotoxicity;GO:0006958 complement activation, classical pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 54.9,
        "record_id": "P01857-2",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q01804-1",
        "uniprot_id": [
            {
                "id": "OTUD4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q01804",
                "type": "external"
            }
        ],
        "mass": 124045.0,
        "length": 1114,
        "protein_name": "OTU domain-containing protein 4",
        "gene_name": "OTUD4",
        "organism": "Human",
        "refseq_name": "OTU domain-containing protein 4 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001096123",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001096123",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "OTUD4; HIN-1; KIAA1046",
        "gene_names_refseq": "DUBA6; HIN1; HSHIN1; OTUD4",
        "protein_names_uniprotkb": "OTU domain-containing protein 4; 3.4.19.12; HIV-1-induced protein HIN-1",
        "protein_names_refseq": "HIV-1 induced protein HIN-1; OTU domain-containing protein 4 isoform 3; OTU domain-containing protein 4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:54726)",
        "pathway_count": 1,
        "publication_count": 55,
        "publication_id_list": "11237011;1475186;15144186;16964243;17081983;18669648;19690332;20068231;21406692;22223895;23186163;23301498;23656588;23827681;24275569;24715725;25880248;25892735;25944111;26992070;28832583;29242379;29351928;29393594;29395066;29493099;29557506;30429286;31373491;31844290;32157095;32357974;32387766;32897882;32938616;32983136;33214551;33717175;33912179;33968037;33981976;34019948;34171305;34509645;35051231;35138101;35580925;37642406;38040050;38429268;38518721;38553613;38665916;39531497;40215271",
        "class_list": "",
        "function": "Alternatively spliced transcript variants have been found for this gene. The smaller protein isoform encoded by the shorter transcript variant is found only in HIV-1 infected cells. [provided by RefSeq, Jul 2010]., [RefSeq]; Deubiquitinase which hydrolyzes the isopeptide bond between the ubiquitin C-terminus and the lysine epsilon-amino group of the target protein (PubMed:23827681, PubMed:25944111, PubMed:29395066). May negatively regulate inflammatory and pathogen recognition signaling in innate immune response. Upon phosphorylation at Ser-202 and Ser-204 residues, via IL-1 receptor and Toll-like receptor signaling pathway, specifically deubiquitinates 'Lys-63'-polyubiquitinated MYD88 adapter protein triggering down-regulation of NF-kappa-B-dependent transcription of inflammatory mediators (PubMed:29395066). Independently of the catalytic activity, acts as a scaffold for alternative deubiquitinases to assemble specific deubiquitinase-substrate complexes. Associates with USP7 and USP9X deubiquitinases to stabilize alkylation repair enzyme ALKBH3, thereby promoting the repair of alkylated DNA lesions (PubMed:25944111)., [UniProtKB, PubMed, PubMed, PubMed]; Deubiquitinating enzyme OTUD4 regulates metastasis in triple-negative breast cancer by stabilizing Snail1., [RefSeq, PubMed]; Deubiquitinating enzyme OTUD4 stabilizes RBM47 to induce ATF3 transcription: a novel mechanism underlying the restrained malignant properties of ccRCC cells., [RefSeq, PubMed]; NRF2 regulates EGF stability through OTUD4 in lung adenocarcinoma., [RefSeq, PubMed]; OTUD4 is a positive regulator of ALKBH2 and ALKBH3, two DNA demethylases critical for alkylation repair., [RefSeq, PubMed]; OTUD4 promotes the progression of glioblastoma by deubiquitinating CDK1 and activating MAPK signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; OTUD4 regulates metastasis and chemoresistance in melanoma by stabilizing Snail1., [RefSeq, PubMed]; The syndrome of hypogonadotropic hypogonadism, ataxia, and dementia can be caused by inactivating mutations in RNF216 or by the combination of mutations in RNF216 and OTUD4, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 9,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 21,
        "reported_mutagensis": 7,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DYS4;Q147U2;Q1ZYK1;Q6PG39;Q96MQ5;Q9NT94;Q9UPV6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0060090 molecular adaptor activity;GO:0003723 RNA binding;GO:0004843 cysteine-type deubiquitinase activity;GO:0061578 K63-linked deubiquitinase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:2000660 negative regulation of interleukin-1-mediated signaling pathway;GO:0006508 proteolysis;GO:0070536 protein K63-linked deubiquitination;GO:0006307 DNA alkylation repair;GO:0034122 negative regulation of toll-like receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q01804-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16827-1",
        "uniprot_id": [
            {
                "id": "PTPRO_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16827",
                "type": "external"
            }
        ],
        "mass": 138344.0,
        "length": 1216,
        "protein_name": "Receptor-type tyrosine-protein phosphatase O",
        "gene_name": "PTPRO",
        "organism": "Human",
        "refseq_name": "receptor-type tyrosine-protein phosphatase O isoform b precursor",
        "refseq_ac": [
            {
                "id": "NP_002839",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002839",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTPRO; GLEPP1; PTPU2",
        "gene_names_refseq": "GLEPP1; NPHS6; PTP-OC; PTP-U2; PTPROT; PTPRO; PTPU2; R-PTP-O",
        "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase O; 3.1.3.48; Glomerular epithelial protein 1; PTP-U2; PTPase U2; Protein tyrosine phosphatase U2; R-PTP-O",
        "protein_names_refseq": "PTP phi; PTPase U2; glomerular epithelial protein 1; osteoclastic transmembrane protein-tyrosine phosphatase; phosphotyrosine phosphatase U2; protein tyrosine phosphatase PTP-U2; receptor-type tyrosine-protein phosphatase O isoform b precursor",
        "tax_id": 9606,
        "disease": "nephrotic syndrome type 6 (Disease Ontology:DOID:0080384)",
        "pathway": " (hsa:5800);  (R-HSA-9034015)",
        "pathway_count": 2,
        "publication_count": 24,
        "publication_id_list": "10.1101/2023.09.13.557529;10498613;11237011;18058037;19167335;21722858;28228285;29351928;29557506;29789417;30783489;32157095;32387766;32983136;34509645;35051231;35580925;36003382;36241641;37074911;38182570;39276174;7665166;7753550",
        "class_list": "",
        "function": "PTPRO-related CD8(+) T-cell signatures predict prognosis and immunotherapy response in patients with breast cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Protein tyrosine phosphatase PTPRO represses lung adenocarcinoma progression by inducing mitochondria-dependent apoptosis and restraining tumor metastasis. Publication Status: Online-Only, [RefSeq, PubMed]; Protein tyrosine phosphatase receptor type O serves as a key regulator of insulin resistance-induced alpha-synuclein aggregation in Parkinson's disease. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the R3 subtype family of receptor-type protein tyrosine phosphatases. These proteins are localized to the apical surface of polarized cells and may have tissue-specific functions through activation of Src family kinases. This gene contains two distinct promoters, and alternatively spliced transcript variants encoding multiple isoforms have been observed. The encoded proteins may have multiple isoform-specific and tissue-specific functions, including the regulation of osteoclast production and activity, inhibition of cell proliferation and facilitation of apoptosis. This gene is a candidate tumor suppressor, and decreased expression of this gene has been observed in several types of cancer. [provided by RefSeq, May 2011]., [RefSeq]",
        "predicted_glycosites": 13,
        "predicted_n_glycosites": 12,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 64,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 6,
        "disease_count": 1,
        "glyco_site_count": 17,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AV39;Q13101;Q8IYG3;Q9UBF0;Q9UBT5",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21",
                "type": "external"
            },
            {
                "id": "3.1.3.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity;GO:0045296 cadherin binding;GO:0017147 Wnt-protein binding;GO:0005001 transmembrane receptor protein tyrosine phosphatase activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0098982 GABA-ergic synapse;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0030027 lamellipodium",
        "go_biological_process": "GO:0036060 slit diaphragm assembly;GO:0090260 negative regulation of retinal ganglion cell axon guidance;GO:0090090 negative regulation of canonical Wnt signaling pathway;GO:0003093 regulation of glomerular filtration;GO:0000902 cell morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q16827-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15262-1",
        "uniprot_id": [
            {
                "id": "PTPRK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15262",
                "type": "external"
            }
        ],
        "mass": 162102.0,
        "length": 1439,
        "protein_name": "Receptor-type tyrosine-protein phosphatase kappa",
        "gene_name": "PTPRK",
        "organism": "Human",
        "refseq_name": "receptor-type tyrosine-protein phosphatase kappa isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001129120",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129120",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTPRK; PTPK",
        "gene_names_refseq": "PTPRK; R-PTP-kappa",
        "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase kappa; 3.1.3.48; Protein-tyrosine phosphatase kappa; R-PTP-kappa",
        "protein_names_refseq": "dJ480J14.2.1 (protein tyrosine phosphatase, receptor type, K (R-PTP-KAPPA, protein tyrosine phosphatase kappa, protein tyrosine phosphatase kappa; protein-tyrosine phosphatase kappa; protein-tyrosine phosphatase, receptor type, kappa; receptor-type tyrosine-protein phosphatase kappa isoform a precursor; receptor-type tyrosine-protein phosphatase kappa",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5796);  (R-HSA-182971)",
        "pathway_count": 2,
        "publication_count": 94,
        "publication_id_list": "10.1101/2023.09.13.557529;10514377;10652316;10953014;11237011;11823423;11894095;12072436;12218189;12234920;12593795;12593796;14505571;14985334;15021893;15117950;15465819;15475003;15701692;15962011;16407834;19054389;19159218;19167335;19349973;19814798;19836242;21376233;23090970;24190977;25263444;25502872;25576301;25645385;25880248;26154972;27846572;28228285;28832583;29242379;29391424;29393594;29557506;29671580;29741879;29786170;29789417;30315122;30429286;30484775;30524438;30833945;31154438;31217245;31530632;31844290;31848261;32125861;32157095;32350084;32357974;32387766;32488085;32502341;32938616;32983136;33298915;33592498;33717175;33912179;33968037;34087483;34171305;34185709;34357683;34590584;35051231;35318648;35580925;36010968;36129915;36215666;36241641;36284347;36436563;36611909;37074911;37938771;7541030;7542744;7657591;8621719;8663237;9047348",
        "class_list": "",
        "function": "A MET-PTPRK kinase-phosphatase rheostat controls ZNRF3 and Wnt signaling. Publication Status: Online-Only, [RefSeq, PubMed]; Determinants of receptor tyrosine phosphatase homophilic adhesion: Structural comparison of PTPRK and PTPRM extracellular domains., [RefSeq, PubMed]; Investigation of cell signalings and therapeutic targets in PTPRK-RSPO3 fusion-positive colorectal cancer. Publication Status: Online-Only, [RefSeq, PubMed]; PTPRK, an EGFR Phosphatase, Is Decreased in CeD Biopsies and Intestinal Organoids. Publication Status: Online-Only, [RefSeq, PubMed]; Regulation of processes involving cell contact and adhesion such as growth control, tumor invasion, and metastasis. Negative regulator of EGFR signaling pathway. Forms complexes with beta-catenin and gamma-catenin/plakoglobin. Beta-catenin may be a substrate for the catalytic activity of PTPRK/PTP-kappa., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and two tandem catalytic domains, and thus represents a receptor-type PTP. The extracellular region contains a meprin-A5 antigen-PTP mu (MAM) domain, an Ig-like domain and four fibronectin type III-like repeats. This PTP was shown to mediate homophilic intercellular interaction, possibly through the interaction with beta- and gamma-catenin at adherens junctions. Expression of this gene was found to be stimulated by TGF-beta 1, which may be important for the inhibition of keratinocyte proliferation. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 6,
        "predicted_n_glycosites": 6,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 7,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 7,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 46,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 59,
        "disease_count": 0,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RTQ8;B7ZMG0;Q14763;Q5TG10;Q5TG11",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21",
                "type": "external"
            },
            {
                "id": "3.1.3.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0019901 protein kinase binding;GO:0008013 beta-catenin binding;GO:0045295 gamma-catenin binding;GO:0005001 transmembrane receptor protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005912 adherens junction;GO:0009986 cell surface;GO:0016020 membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0007165 signal transduction;GO:0008285 negative regulation of cell population proliferation;GO:0016477 cell migration;GO:0031175 neuron projection development",
        "synthesized_glycan_count": 0,
        "hit_score": 16.1,
        "record_id": "Q15262-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1000000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15197-1",
        "uniprot_id": [
            {
                "id": "EPHB6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15197",
                "type": "external"
            }
        ],
        "mass": 110700.0,
        "length": 1021,
        "protein_name": "Ephrin type-B receptor 6",
        "gene_name": "EPHB6",
        "organism": "Human",
        "refseq_name": "ephrin type-B receptor 6 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001267724",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001267724",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPHB6",
        "gene_names_refseq": "EPHB6; HEP",
        "protein_names_uniprotkb": "Ephrin type-B receptor 6; HEP; Tyrosine-protein kinase-defective receptor EPH-6",
        "protein_names_refseq": "ephrin type-B receptor 6 isoform b; ephrin type-B receptor 6; human kinase-defective Eph-family receptor protein; tyrosine-protein kinase-defective receptor EPH-6",
        "tax_id": 9606,
        "disease": "silicosis (Disease Ontology:DOID:10325); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); dilated cardiomyopathy (Disease Ontology:DOID:12930); alcohol use disorder (Disease Ontology:DOID:1574); status epilepticus (Disease Ontology:DOID:1824); lung non-small cell carcinoma (Disease Ontology:DOID:3908); hyperglycemia (Disease Ontology:DOID:4195); congestive heart failure (Disease Ontology:DOID:6000); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:2051);  (R-HSA-2682334);  (R-HSA-3928662);  (R-HSA-3928664);  (R-HSA-3928665)",
        "pathway_count": 5,
        "publication_count": 66,
        "publication_id_list": "10047984;10219243;10848605;10995436;11058585;11134074;11237011;11448999;11557983;11580899;11713248;11747816;11780069;11804587;11983165;12084815;12495863;12517763;12546821;12676796;12695502;12702722;12973357;14988728;15340161;15351694;15378065;15548136;15721239;15800193;15848800;15955811;16298995;16511561;16959974;17310244;17322526;17344846;17428795;17440041;17548511;17928214;18425388;18713744;18754880;19234485;19525919;19553453;19915143;20496116;2201922;29557506;29789417;31611695;32938616;32983136;33592498;33968037;34357683;34431498;35051231;36010968;37294054;7478585;9207182;9499402",
        "class_list": "",
        "function": "EphB6 deficiency in intestinal neurons promotes tumor growth in colorectal cancer by neurotransmitter GABA signaling., [RefSeq, PubMed]; Kinase-defective receptor for members of the ephrin-B family. Binds to ephrin-B1 and ephrin-B2. Modulates cell adhesion and migration by exerting both positive and negative effects upon stimulation with ephrin-B2. Inhibits JNK activation, T-cell receptor-induced IL-2 secretion and CD25 expression upon stimulation with ephrin-B2., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; This gene encodes a member of a family of transmembrane proteins that function as receptors for ephrin-B family proteins. Unlike other members of this family, the encoded protein does not contain a functional kinase domain. Activity of this protein can influence cell adhesion and migration. Expression of this gene is downregulated during tumor progression, suggesting that the protein may suppress tumor invasion and metastasis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 16,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 10,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D2I7;A8CDT5;D3DXD3;Q2TB23;Q2TB24",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0038023 signaling receptor activity;GO:0005003 ephrin receptor activity;GO:0004672 protein kinase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0009986 cell surface",
        "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0007411 axon guidance",
        "synthesized_glycan_count": 0,
        "hit_score": 6.7,
        "record_id": "O15197-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0000000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P16422-1",
        "uniprot_id": [
            {
                "id": "EPCAM_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P16422",
                "type": "external"
            }
        ],
        "mass": 34932.0,
        "length": 314,
        "protein_name": "Epithelial cell adhesion molecule",
        "gene_name": "EPCAM",
        "organism": "Human",
        "refseq_name": "epithelial cell adhesion molecule precursor",
        "refseq_ac": [
            {
                "id": "NP_002345",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002345",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPCAM; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1",
        "gene_names_refseq": "Ber-Ep4; BerEp4; DIAR5; EGP-2; EGP314; EGP40; EPCAM; ESA; HNPCC8; KS1/4; KSA; LYNCH8; M4S1; MIC18; MK-1; MOC-31; TACSTD1; TROP1",
        "protein_names_uniprotkb": "Epithelial cell adhesion molecule; Adenocarcinoma-associated antigen; Cell surface glycoprotein Trop-1; EGP314; EGP; Ep-CAM; Epithelial cell surface antigen; Epithelial glycoprotein 314; Epithelial glycoprotein; KS 1/4 antigen; KSA; Major gastrointestinal tumor-associated protein GA733-2; Tumor-associated calcium signal transducer 1; hEGP314",
        "protein_names_refseq": "adenocarcinoma-associated antigen; cell surface glycoprotein Trop-1; epithelial cell adhesion molecule precursor; epithelial glycoprotein 314; human epithelial glycoprotein-2; major gastrointestinal tumor-associated protein GA733-2; membrane component, chromosome 4, surface marker (35kD glycoprotein); trophoblast cell surface antigen 1; tumor-associated calcium signal transducer 1",
        "tax_id": 9606,
        "disease": "congenital diarrhea 5 with tufting enteropathy (Disease Ontology:DOID:0060776); hereditary nonpolyposis colorectal cancer type 8 (Disease Ontology:DOID:0070270); middle cerebral artery infarction (Disease Ontology:DOID:3525); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:4072);  (R-HSA-202733);  (R-HSA-9638630);  (R-HSA-9927418);  (R-HSA-9927426);  (R-HSA-9927432);  (R-HSA-9938206)",
        "pathway_count": 7,
        "publication_count": 105,
        "publication_id_list": "10.1038/emboj.2013.79;10606205;10764623;11080501;11207550;11237011;11256994;11564780;11739641;11779189;11812992;12070135;12208882;12469115;12782713;14529530;14615387;15000751;15195135;15528364;15681301;15721307;1591491;15922867;16054130;16258728;16297198;16585556;16691243;16737840;16783819;17064312;17099249;17116209;17167768;17172599;17322099;17379836;17442946;17452516;17505016;17525755;17563375;17580308;17600130;17615384;17625065;18508581;18572020;19098912;19159218;19279206;19785009;20064925;20683652;2108441;21193412;21659548;2333300;23584533;23945545;24043627;24142340;2463074;2469722;24764293;2538457;25576301;28510447;2911574;29314611;29557506;29741879;31154438;32350084;32938616;33324790;34087483;35051231;35251023;35472243;35580925;36241641;36853838;37074911;38291183;38415550;38971196;39010070;39085882;468991;7509040;7521878;7693697;8163559;8166770;8314844;8382772;9052782;9169774;9242610;9295288;9382878;9693095;9763524",
        "class_list": "",
        "function": "Immune evasion in lung metastasis of leiomyosarcoma: upregulation of EPCAM inhibits CD8[+] T cell infiltration., [RefSeq, PubMed]; Intracellular domain of epithelial cell adhesion molecule induces Wnt receptor transcription to promote colorectal cancer progression. Publication Status: Online-Only, [RefSeq, PubMed]; May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; PARP-1, EpCAM, and FRalpha as potential targets for intraoperative detection and delineation of endometriosis: a quantitative tissue expression analysis. Publication Status: Online-Only, [RefSeq, PubMed]; TLR4, IgA and EpCAM Expression in Colorectal Cancer and Their Possible Association with Microbiota as a Pathogenic Factor; An Immunohistochemical and Genetic Study. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy. [provided by RefSeq, Dec 2008]., [RefSeq]; WNT Oncogenic Transcription Requires MYC Suppression of Lysosomal Activity and EPCAM Stabilization in Gastric Tumors., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 1,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 48,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 65,
        "disease_count": 4,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "P18180;Q6FG26;Q6FG49;Q96C47;Q9UCD0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0044877 protein-containing complex binding;GO:0098641 cadherin binding involved in cell-cell adhesion",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005923 bicellular tight junction;GO:0009986 cell surface;GO:0016323 basolateral plasma membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:2000648 positive regulation of stem cell proliferation;GO:0008284 positive regulation of cell population proliferation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0048863 stem cell differentiation;GO:0001657 ureteric bud development",
        "synthesized_glycan_count": 0,
        "hit_score": 17.8,
        "record_id": "P16422-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100100000001.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BVX2-1",
        "uniprot_id": [
            {
                "id": "T106C_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BVX2",
                "type": "external"
            }
        ],
        "mass": 27875.0,
        "length": 250,
        "protein_name": "Transmembrane protein 106C",
        "gene_name": "TMEM106C",
        "organism": "Human",
        "refseq_name": "transmembrane protein 106C isoform b",
        "refseq_ac": [
            {
                "id": "NP_001137313",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001137313",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TMEM106C; EMOC",
        "gene_names_refseq": "TMEM106C",
        "protein_names_uniprotkb": "Transmembrane protein 106C; Endoplasmic reticulum membrane protein overexpressed in cancer",
        "protein_names_refseq": "endoplasmic reticulum membrane protein overexpressed in cancer; transmembrane protein 106C isoform b",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79022)",
        "pathway_count": 1,
        "publication_count": 55,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;22424782;22544926;23481700;24190977;24715725;25066864;25418920;25576301;25645385;25807930;26154972;26929215;26992070;28218747;28228285;28514659;28832583;28904123;29242379;29393594;29493099;29557506;29632046;30315122;31092671;31154438;31844290;32037603;32157095;32161166;32265295;32350084;32357974;32387766;32897882;32938616;33141586;33298915;33392160;33591950;33592498;33912179;33968037;33981976;34357683;34476506;34509645;35154160;35251023;35580925;36010968;36215666;36241641",
        "class_list": "",
        "function": "LINC00238 inhibits hepatic carcinoma progression by activating TMEM106Cmediated apoptosis pathway., [RefSeq, PubMed]; TMEM106C contributes to the malignant characteristics and poor prognosis of hepatocellular carcinoma., [RefSeq, PubMed]; Transmembrane protein 106C promotes the development of hepatocellular carcinoma., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R998;B7Z5M4;Q3B761",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane;GO:0012505 endomembrane system",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 5.8,
        "record_id": "Q9BVX2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13322-1",
        "uniprot_id": [
            {
                "id": "GRB10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13322",
                "type": "external"
            }
        ],
        "mass": 67231.0,
        "length": 594,
        "protein_name": "Growth factor receptor-bound protein 10",
        "gene_name": "GRB10",
        "organism": "Human",
        "refseq_name": "growth factor receptor-bound protein 10 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001001549",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001001549",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GRB10; GRBIR; KIAA0207",
        "gene_names_refseq": "GRB-IR; GRB10; Grb-10; IRBP; MEG1; RSS",
        "protein_names_uniprotkb": "Growth factor receptor-bound protein 10; GRB10 adapter protein; Insulin receptor-binding protein Grb-IR",
        "protein_names_refseq": "GRB10 adapter protein; GRB10 adaptor protein; growth factor receptor-bound protein 10 isoform b; insulin receptor-binding protein Grb-IR; maternally expressed gene 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2887);  (R-HSA-1433557);  (R-HSA-74713);  (R-HSA-74749);  (R-HSA-74751);  (R-HSA-8853659);  (R-HSA-9607240);  (R-HSA-9648895)",
        "pathway_count": 8,
        "publication_count": 198,
        "publication_id_list": "10102273;10218944;10323868;10358045;10377264;10397721;10427092;10448070;10523831;10523834;10679268;10783894;10856193;10861285;10871840;10884405;10982836;10995764;11000521;11002419;11027663;11063744;11075717;11094066;11163539;11237011;11237712;11241327;11360177;11390647;11395417;11470823;11491658;11494148;11520784;11527390;11707405;11809791;11886862;12062105;12192036;12242309;12493740;12551896;12660731;12771945;12824176;12853971;12878163;1371879;1375232;1381360;14615605;14630918;14766744;14981546;15044950;15060076;15069075;15143187;15286081;15316008;15526160;15569713;15722337;15952796;16129412;16266983;16434550;16483568;16684964;16737840;16814735;16873377;16964243;17140605;1721591;17254966;17255936;17267404;17344430;17376403;17662946;17726049;18055463;18083107;18220336;18391968;18669648;18697750;18787071;19064725;19413330;19438505;19477218;19487367;19648926;19664994;19805105;20068231;20304997;20423929;21389326;21659604;21827948;21884975;23168613;23186163;23246379;23876217;25645385;25931127;26895103;26992070;27536065;28522571;28576946;28814160;28832583;28851395;29242379;29309929;29485866;29557506;29704617;29964125;30620550;31066629;31085175;31844290;32157095;32387766;32938616;32983136;33592498;33968037;33969901;33981976;34171305;35051231;36010968;36241641;36284347;37179120;37938771;40596516;7479769;7506952;7509796;7523381;7526158;7536744;7665556;7680037;7739560;8145851;8479541;8611693;8628282;8631863;8636116;8637703;8647802;8662982;8663426;8674117;8695790;8702728;8774734;8798417;8810325;8816480;8950973;8990121;9006901;9038210;9045650;9047384;9111318;9153226;9192684;9256427;9299438;9355737;9360986;9407096;9446650;9491986;9553107;9609109;9690470;9753425;9764818;9799234;9872323;9881709;9883723;9918857",
        "class_list": "",
        "function": "Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Circ_0009910 shuttled by exosomes regulates proliferation, cell cycle and apoptosis of acute myeloid leukemia cells by regulating miR-5195-3p/GRB10 axis., [RefSeq, PubMed]; GRB10 gene is expressed from the paternal allele in the brain, but from the maternal allele in the placental trophoblasts., [RefSeq, PubMed]; GRB10 is a novel factor associated with gastric cancer proliferation and prognosis., [RefSeq, PubMed]; The product of this gene belongs to a small family of adapter proteins that are known to interact with a number of receptor tyrosine kinases and signaling molecules. This gene encodes a growth factor receptor-binding protein that interacts with insulin receptors and insulin-like growth-factor receptors. Overexpression of some isoforms of the encoded protein inhibits tyrosine kinase activity and results in growth suppression. This gene is imprinted in a highly isoform- and tissue-specific manner, with expression observed from the paternal allele in the brain, and from the maternal allele in the placental trophoblasts. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Oct 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 20,
        "reported_mutagensis": 14,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D258;A7VJ95;A8K0E6;D3DVM9;O00427;O00701;O75222;Q92606;Q92907;Q92948",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005158 insulin receptor binding;GO:0042802 identical protein binding;GO:0030159 signaling receptor complex adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0035556 intracellular signal transduction;GO:0032868 response to insulin;GO:0008286 insulin receptor signaling pathway;GO:0030178 negative regulation of Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 20.1,
        "record_id": "Q13322-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UF33-1",
        "uniprot_id": [
            {
                "id": "EPHA6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UF33",
                "type": "external"
            }
        ],
        "mass": 116379.0,
        "length": 1036,
        "protein_name": "Ephrin type-A receptor 6",
        "gene_name": "EPHA6",
        "organism": "Human",
        "refseq_name": "ephrin type-A receptor 6 isoform c",
        "refseq_ac": [
            {
                "id": "NP_001265229",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265229",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPHA6; EHK2; HEK12",
        "gene_names_refseq": "EHK-2; EHK2; EK12; EPA6; EPHA6; HEK12; PRO57066",
        "protein_names_uniprotkb": "Ephrin type-A receptor 6; 2.7.10.1; EHK-2; EK12; EPH homology kinase 2; EPH-like kinase 12",
        "protein_names_refseq": "EPH homology kinase 2; EPH-like kinase 12; ephrin receptor EphA6; ephrin type-A receptor 6 isoform c; ephrin type-A receptor 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285220);  (R-HSA-2682334);  (R-HSA-3928663);  (R-HSA-3928665)",
        "pathway_count": 4,
        "publication_count": 31,
        "publication_id_list": "10769020;10848605;11179879;11237011;11448999;11780069;12084815;12495863;12973357;14726470;15351694;15848799;15848800;16511561;17322526;17344846;17428795;17928214;18713744;19525919;20496116;28832583;29208002;29242379;29393594;29557506;31483918;31844290;33141586;33392160;9499402",
        "class_list": "",
        "function": "Our data imply that EPHA6 expression is beneficial for glioblastoma multiforme inhibition, particularly in combination with activation of BMP-2 signaling.These results suggest that EPHA6 expression or protein levels could be used as biomarkers for identification of subsets of glioblastoma multiforme patients who might benefit from BMP treatment., [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; The EPHA6 rs4857055 C > T SNP is a novel candidate gene for hypertension in the Korean population. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 3,
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        "secondary_ac_list": "D6RAL5",
        "ec_number_list": [
            {
                "id": "3.4.24.81",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
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                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
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                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
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            }
        ],
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        "protein_name": "Ubiquitin-like protein ISG15",
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            {
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            }
        ],
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        "protein_names_uniprotkb": "Ubiquitin-like protein ISG15; IP17; Interferon-induced 15 kDa protein; Interferon-induced 17 kDa protein; Ubiquitin cross-reactive protein; hUCRP",
        "protein_names_refseq": "interferon, alpha-inducible protein (clone IFI-15K); interferon-induced 17-kDa/15-kDa protein; interferon-stimulated protein, 15 kDa; ubiquitin cross-reactive protein; ubiquitin-like protein ISG15",
        "tax_id": 9606,
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        "function": "Case Report: ISG15 deficiency caused by novel variants in two families and effective treatment with Janus kinase inhibition. Publication Status: Online-Only, [RefSeq, PubMed]; Dynamic molecular network analysis of iPSC-Purkinje cells differentiation delineates roles of ISG15 in SCA1 at the earliest stage. Publication Status: Online-Only, [RefSeq, PubMed]; Evaluation of long non-coding RNAs EGOT, NRAV, NRIR and mRNAs ISG15 and IFITM3 expressions in COVID-19 patients., [RefSeq, PubMed]; ISG15 Promotes Progression and Gemcitabine Resistance of Pancreatic Cancer Cells Through ATG7. Publication Status: Online-Only, [RefSeq, PubMed]; ISG15 accelerates acute kidney injury and the subsequent AKI-to-CKD transition by promoting TGFbetaR1 ISGylation. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a ubiquitin-like protein that is conjugated to intracellular target proteins upon activation by interferon-alpha and interferon-beta. Several functions have been ascribed to the encoded protein, including chemotactic activity towards neutrophils, direction of ligated target proteins to intermediate filaments, cell-to-cell signaling, and antiviral activity during viral infections. While conjugates of this protein have been found to be noncovalently attached to intermediate filaments, this protein is sometimes secreted. [provided by RefSeq, Dec 2012]., [RefSeq]; Ubiquitin-like protein which plays a key role in the innate immune response to viral infection either via its conjugation to a target protein (ISGylation) or via its action as a free or unconjugated protein (PubMed:27564865, PubMed:39465252). ISGylation involves a cascade of enzymatic reactions involving E1, E2, and E3 enzymes which catalyze the conjugation of ISG15 to a lysine residue in the target protein (PubMed:33727702). Its target proteins include IFIT1, MX1/MxA, PPM1B, UBE2L6, UBA7, CHMP5, CHMP2A, CHMP4B and CHMP6. Isgylation of the viral sensor IFIH1/MDA5 promotes IFIH1/MDA5 oligomerization and triggers activation of innate immunity against a range of viruses, including coronaviruses, flaviviruses and picornaviruses (PubMed:33727702). Can also isgylate: EIF2AK2/PKR which results in its activation, RIGI which inhibits its function in antiviral signaling response, EIF4E2 which enhances its cap structure-binding activity and translation-inhibition activity, UBE2N and UBE2E1 which negatively regulates their activity, IRF3 which inhibits its ubiquitination and degradation and FLNB which prevents its ability to interact with the upstream activators of the JNK cascade thereby inhibiting IFNA-induced JNK signaling. Exhibits antiviral activity towards both DNA and RNA viruses, including influenza A, HIV-1 and Ebola virus. Restricts HIV-1 and ebola virus via disruption of viral budding. Inhibits the ubiquitination of HIV-1 Gag and host TSG101 and disrupts their interaction, thereby preventing assembly and release of virions from infected cells. Inhibits Ebola virus budding mediated by the VP40 protein by disrupting ubiquitin ligase activity of NEDD4 and its ability to ubiquitinate VP40. ISGylates influenza A virus NS1 protein which causes a loss of function of the protein and the inhibition of virus replication. The secreted form of ISG15 can: induce natural killer cell proliferation, act as a chemotactic factor for neutrophils and act as a IFN-gamma-inducing cytokine playing an essential role in antimycobacterial immunity. The secreted form acts through the integrin ITGAL/ITGB2 receptor to initiate activation of SRC family tyrosine kinases including LYN, HCK and FGR which leads to secretion of IFNG and IL10; the interaction is mediated by ITGAL (PubMed:29100055)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q5SVA4;Q7Z2G2;Q96GF0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding;GO:0003735 structural constituent of ribosome;GO:0031386 protein tag activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0070585 protein localization to mitochondrion;GO:0007229 integrin-mediated signaling pathway;GO:0045087 innate immune response;GO:0051607 defense response to virus;GO:0045071 negative regulation of viral genome replication",
        "synthesized_glycan_count": 0,
        "hit_score": 46.6,
        "record_id": "P05161-1",
        "record_type": "protein",
        "filter_code": "0000000.0100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6PVY3-1",
        "uniprot_id": [
            {
                "id": "F177B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6PVY3",
                "type": "external"
            }
        ],
        "mass": 18145.0,
        "length": 158,
        "protein_name": "Protein FAM177B",
        "gene_name": "FAM177B",
        "organism": "Human",
        "refseq_name": "protein FAM177B",
        "refseq_ac": [
            {
                "id": "NP_001311009",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311009",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM177B",
        "gene_names_refseq": "FAM177B",
        "protein_names_uniprotkb": "Protein FAM177B",
        "protein_names_refseq": "protein FAM177B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:400823)",
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        "publication_id_list": "11237011;29351928;34087483;34185709",
        "class_list": "",
        "function": "",
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        "secondary_ac_list": "Q6ZUN8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
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        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "A6PVY3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P23142-1",
        "uniprot_id": [
            {
                "id": "FBLN1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P23142",
                "type": "external"
            }
        ],
        "mass": 77214.0,
        "length": 703,
        "protein_name": "Fibulin-1",
        "gene_name": "FBLN1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "FBLN1; PP213",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Fibulin-1; FIBL-1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "synpolydactyly (Disease Ontology:DOID:0060242)",
        "pathway": " (hsa:2192);  (R-HSA-2129379)",
        "pathway_count": 2,
        "publication_count": 59,
        "publication_id_list": "10.1101/2023.09.13.557529;10025398;10318851;10424889;10544250;10646116;10930463;11237011;11238726;11792823;11829738;11836357;11850827;11970960;12200142;12358597;12415008;12429738;12644824;1400330;14701737;15498874;1708799;17324935;18339631;18477386;18702456;19139490;21646718;2269669;23090970;24084572;24190977;2527614;29314611;29393594;29557506;29632711;29671580;29741879;30459171;34019948;34411563;35051231;37074911;37217939;38665916;7500359;7534784;7642629;8552629;8737292;9106159;9278415;9393974;9466671;9725916;9811350;9927660",
        "class_list": "",
        "function": "Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "B0QY42;B1AHL4;P23143;P23144;P37888;Q5TIC4;Q8TBH8;Q9HBQ5;Q9UC21;Q9UGR4;Q9UH41",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding;GO:0016504 peptidase activator activity;GO:0042802 identical protein binding;GO:0005509 calcium ion binding;GO:0044877 protein-containing complex binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome;GO:0005604 basement membrane",
        "go_biological_process": "GO:0071635 negative regulation of transforming growth factor beta production;GO:1904237 positive regulation of substrate-dependent cell migration, cell attachment to substrate;GO:2000647 negative regulation of stem cell proliferation;GO:0007162 negative regulation of cell adhesion;GO:0010628 positive regulation of gene expression",
        "synthesized_glycan_count": 0,
        "hit_score": 12.4,
        "record_id": "P23142-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q53HC9-1",
        "uniprot_id": [
            {
                "id": "EIPR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q53HC9",
                "type": "external"
            }
        ],
        "mass": 43603.0,
        "length": 387,
        "protein_name": "EARP and GARP complex-interacting protein 1",
        "gene_name": "EIPR1",
        "organism": "Human",
        "refseq_name": "EARP and GARP complex-interacting protein 1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_003301",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003301",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EIPR1; TSSC1",
        "gene_names_refseq": "EIPR-1; EIPR1; TSSC1",
        "protein_names_uniprotkb": "EARP and GARP complex-interacting protein 1; Endosome-associated recycling protein-interacting protein; Golgi-associated retrograde protein-interacting protein; Tumor-suppressing STF cDNA 1 protein; Tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein",
        "protein_names_refseq": "EARP and GARP complex-interacting protein 1 isoform 2; EARP and GARP complex-interacting protein 1; EARP-interacting protein; Golgi-associated retrograde protein-interacting protein; endosome-associated recycling protein-interacting protein; protein TSSC1; tumor suppressing subtransferable candidate 1; tumor-suppressing STF cDNA 1 protein; tumor-suppressing subchromosomal transferable fragment candidate gene 1 protein; tumor-suppressing subtransferable fragment candidate gene 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7260)",
        "pathway_count": 1,
        "publication_count": 45,
        "publication_id_list": "11237011;19690332;21872626;21993680;23481700;23933319;25418920;26154972;26375851;26929215;26992070;27440922;27920218;28218747;28228285;28510447;28832583;28834231;29242379;29437277;29493099;29508533;29557506;29786170;30410026;31844290;32157095;32357974;32502341;32897882;33592498;33691108;33912179;33936100;33963283;33968037;34171305;34357683;34932366;35051231;35580925;36284347;37938771;40914422;9403053",
        "class_list": "",
        "function": "Acts as a component of endosomal retrieval machinery that is involved in protein transport from early endosomes to either recycling endosomes or the trans-Golgi network (PubMed:27440922). Mediates the recruitment of Golgi-associated retrograde protein (GARP) complex to the trans-Golgi network and controls early endosome-to-Golgi transport of internalized protein (PubMed:27440922). Promotes the recycling of internalized transferrin receptor (TFRC) to the plasma membrane through interaction with endosome-associated recycling protein (EARP) complex (PubMed:27440922). Controls proper insulin distribution and secretion, and retention of cargo in mature dense core vesicles (By similarity). Required for the stability of the endosome-associated retrograde protein (EARP) complex subunits and for proper localization and association of EARP with membranes (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB]; Allele-specific DNA methylation maps in monozygotic twins discordant for psychiatric disorders reveal that disease-associated switching at the EIPR1 regulatory loci modulates neural function., [RefSeq, PubMed]; Fluorescence recovery after photobleaching shows that TSSC1 is required for efficient recruitment of GARP to the TGN. These studies thus demonstrate that TSSC1 plays a critical role in endosomal retrieval pathways as a regulator of both GARP and EARP function., [RefSeq, PubMed]; TSSC1 inhibits breast cancer cell invasion. Subsequently, TSSC1 is confirmed as a target of Runx2 and is negatively regulated by Runx2., [RefSeq, PubMed]; This gene has been reported in PMID 9403053 as one of several tumor-suppressing subtransferable fragments located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocortical carcinoma, and lung, ovarian, and breast cancer. Alignment of this gene to genomic sequence data suggests that this gene resides on chromosome 2 rather than chromosome 11. [provided by RefSeq, Dec 2008]., [RefSeq]",
        "predicted_glycosites": 0,
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        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D6W4Y1;O43179;Q53S19;Q53SG2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005802 trans-Golgi network;GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0050796 regulation of insulin secretion;GO:0016567 protein ubiquitination;GO:2001137 positive regulation of endocytic recycling;GO:0032456 endocytic recycling;GO:1905281 positive regulation of retrograde transport, endosome to Golgi",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q53HC9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6X9E4-1",
        "uniprot_id": [
            {
                "id": "FBW12_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6X9E4",
                "type": "external"
            }
        ],
        "mass": 53056.0,
        "length": 464,
        "protein_name": "F-box/WD repeat-containing protein 12",
        "gene_name": "FBXW12",
        "organism": "Human",
        "refseq_name": "F-box/WD repeat-containing protein 12 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001153399",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001153399",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FBXW12; FBW12; FBXO12; FBXO35",
        "gene_names_refseq": "FBW12; FBXO12; FBXO35; FBXW12",
        "protein_names_uniprotkb": "F-box/WD repeat-containing protein 12; F-box and WD-40 domain-containing protein 12; F-box only protein 35",
        "protein_names_refseq": "F-box and WD-40 domain protein 12; F-box and WD-40 domain-containing protein 12; F-box only protein 35; F-box- and WD40-repeat-containing protein; F-box/WD repeat-containing protein 12 isoform 2; F-box/WD repeat-containing protein 12",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:285231);  (R-HSA-8951664);  (R-HSA-983168)",
        "pathway_count": 3,
        "publication_count": 133,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11062501;11069780;11237011;11259415;11292861;11292862;11350924;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12646216;12682069;12759363;12816948;14690597;14734113;14757770;15040455;15224091;15224092;15282312;15361859;15367669;15537541;15571818;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16595681;16647857;16707496;16790436;16849449;16943200;16954532;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18662542;18775313;18776931;18805092;18826954;18851830;18926707;19028597;19250909;19321346;19352404;19452197;19489725;19617556;19748355;19851334;19874575;19940261;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;2261476;22959436;23201271;23333871;23401859;23453757;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24366543;24636985;24793695;24793696;25314029;25349211;25355947;25531226;26171402;26344709;26460955;26617728;26632597;26906416;27030794;27222660;27565346;28115426;29153394;29557506;30610225;32005965;32284348;33444648;35051231;9380723;9668046;9790970;9887101;9891082",
        "class_list": "",
        "function": "FBXO35 gene had a ubiquitously low expression pattern in most human adult tissues. FBXO35 gene was found located in chromosome 3p21., [RefSeq, PubMed]; FBXW12 functions as an E3 ligase constituent to ubiquitinate and degrade IL-22R and that therapeutic FBXW12 inhibition may enhance IL-22 signaling and bolster mucosal host defense and infection containment., [RefSeq, PubMed]; FBXW12 gene is deleted in approximately ten percent of the epithelial ovarian cancer cases studied; such deletions comprised either the FBXW12 promoter or the mRNA-encoding region. Publication Status: Online-Only, [RefSeq, PubMed]; Members of the F-box protein family, such as FBXW12, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603034), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]., [RefSeq]; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex (PubMed:26171402). Promotes degradation of interleukin-22 receptor subunit IL22RA1 in resting and IL22-stimulated conditions by facilitating its ubiquitination (PubMed:26171402). Functions as a cell growth suppressor (PubMed:26171402)., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E9PG36;Q494Y9;Q494Z0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0016567 protein ubiquitination;GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.4,
        "record_id": "Q6X9E4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6NXP2-1",
        "uniprot_id": [
            {
                "id": "GAR1A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6NXP2",
                "type": "external"
            }
        ],
        "mass": 34516.0,
        "length": 309,
        "protein_name": "Golgi-associated RAB2 interactor protein 1A",
        "gene_name": "GARIN1A",
        "organism": "Human",
        "refseq_name": "Golgi-associated RAB2 interactor protein 1A isoform a",
        "refseq_ac": [
            {
                "id": "NP_001012457",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001012457",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GARIN1A; FAM137B; FAM71F2",
        "gene_names_refseq": "FAM137B; FAM71F2; GARIN1A; GARI",
        "protein_names_uniprotkb": "Golgi-associated RAB2 interactor protein 1A",
        "protein_names_refseq": "Golgi associated RAB2 interactor protein 1A; Golgi-associated RAB2 interactor protein 1A isoform a; Golgi-associated RAB2B interactor; family with sequence similarity 137, member B; family with sequence similarity 71 member F2; protein FAM71F2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:346653)",
        "pathway_count": 1,
        "publication_count": 3,
        "publication_id_list": "11237011;17672918;24715725",
        "class_list": "",
        "function": "RAB2B effector protein required for accurate acrosome formation and normal male fertility., [UniProtKB, UniProtKB]; Validated occurrence of an unusual TG 3' splice site in intron 1, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q0VGF6;Q0VGF7;Q86X39",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005794 Golgi apparatus",
        "go_biological_process": "GO:0001675 acrosome assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q6NXP2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P98095-1",
        "uniprot_id": [
            {
                "id": "FBLN2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P98095",
                "type": "external"
            }
        ],
        "mass": 126573.0,
        "length": 1184,
        "protein_name": "Fibulin-2",
        "gene_name": "FBLN2",
        "organism": "Human",
        "refseq_name": "fibulin-2 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001004019",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001004019",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FBLN2",
        "gene_names_refseq": "FBLN2",
        "protein_names_uniprotkb": "Fibulin-2; FIBL-2",
        "protein_names_refseq": "FIBL-2; fibulin-2 isoform a precursor",
        "tax_id": 9606,
        "disease": "intrinsic cardiomyopathy (Disease Ontology:DOID:0060036)",
        "pathway": " (hsa:2199);  (R-HSA-2129379)",
        "pathway_count": 2,
        "publication_count": 57,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10025398;10424889;10544250;10646116;10930463;11237011;11970960;12358597;12415008;12429738;1400330;14701737;1708799;17255108;17324935;18318008;18339631;19159218;20187088;21646718;22171320;23090970;23584533;24190977;26992070;29242379;29741879;29786170;30459171;31154438;31844290;32157095;32350084;32938616;33890711;33971972;34019948;34411563;35051231;35132862;35251023;35580925;35705054;36010968;36608640;37074911;37162505;37543430;38665916;40307207;7500359;7534784;7806230;8737292;9725916",
        "class_list": "",
        "function": "Fibulin-2 Facilitates Malignant Progression of Hepatocellular Carcinoma., [RefSeq, PubMed]; Its binding to fibronectin and some other ligands is calcium dependent. May act as an adapter that mediates the interaction between FBN1 and ELN (PubMed:17255108)., [UniProtKB, PubMed]; Knockdown of FBLN2 suppresses TGF-beta1-induced MRC-5 cell migration and fibrosis by downregulating VTN., [RefSeq, PubMed]; Loss of enteric neuronal Ndrg4 promotes colorectal cancer via increased release of Nid1 and Fbln2., [RefSeq, PubMed]; Rare variant analysis of 4241 pulmonary arterial hypertension cases from an international consortium implicates FBLN2, PDGFD, and rare de novo variants in PAH. Erratum:[Genome Med. 2021 Jun 22;13(1):106. doi: 10.1186/s13073-021-00915-w. PMID: 34158098] Publication Status: Online-Only, [RefSeq, PubMed]; TMT-based quantitative proteomic analysis revealed that FBLN2 and NPR3 are involved in the early osteogenic differentiation of mesenchymal stem cells (MSCs)., [RefSeq, PubMed]; This gene encodes an extracellular matrix protein, which belongs to the fibulin family. This protein binds various extracellular ligands and calcium. It may play a role during organ development, in particular, during the differentiation of heart, skeletal and neuronal structures. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 26,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 26,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 26,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 64,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 39,
        "disease_count": 1,
        "glyco_site_count": 29,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z9C5;Q8IUI0;Q8IUI1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0050840 extracellular matrix binding;GO:0005201 extracellular matrix structural constituent;GO:0030023 extracellular matrix constituent conferring elasticity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0031012 extracellular matrix;GO:1903561 extracellular vesicle;GO:0001527 microfibril;GO:0071953 elastic fiber",
        "go_biological_process": "GO:0010811 positive regulation of cell-substrate adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "P98095-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15653-1",
        "uniprot_id": [
            {
                "id": "IKBB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15653",
                "type": "external"
            }
        ],
        "mass": 37771.0,
        "length": 356,
        "protein_name": "NF-kappa-B inhibitor beta",
        "gene_name": "NFKBIB",
        "organism": "Human",
        "refseq_name": "NF-kappa-B inhibitor beta isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001230045",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230045",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NFKBIB; IKBB; TRIP9",
        "gene_names_refseq": "IKBB; NFKBIB; TRIP9",
        "protein_names_uniprotkb": "NF-kappa-B inhibitor beta; I-kappa-B-beta; IkB-B; IkB-beta; IkappaBbeta; NF-kappa-BIB; TR-interacting protein 9; TRIP-9; Thyroid receptor-interacting protein 9",
        "protein_names_refseq": "I-kappa-B-beta; NF-kappa-B inhibitor beta isoform 2; NF-kappa-B inhibitor beta; NF-kappa-BIB; TR-interacting protein 9; TRIP-9; ikB-B; ikB-beta; ikappaBbeta; nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta; thyroid receptor-interacting protein 9",
        "tax_id": 9606,
        "disease": "collagen disease (Disease Ontology:DOID:854)",
        "pathway": " (hsa:4793);  (R-HSA-1169091);  (R-HSA-1810476);  (R-HSA-445989);  (R-HSA-933542);  (R-HSA-9920951)",
        "pathway_count": 6,
        "publication_count": 122,
        "publication_id_list": "10066435;10230406;10321728;10514424;10593898;10657303;10723127;11237011;11460167;12070292;12118249;12221085;12672800;12732617;14695475;15024091;15145317;16056267;16115877;16286457;16301747;16356855;16573520;16822942;17047224;17428801;1756723;17728323;18462684;18462924;18941233;19066035;19590578;19666475;19909372;20068231;20449947;20696886;23481700;24275569;24714562;24715725;24973451;25576301;26154972;26728094;26992070;27108190;27600516;27701768;27846572;27920218;28228285;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30524438;3129195;31844290;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33691108;33717175;33936100;33968037;33981976;34087483;34171305;34211107;34509645;35051231;35561310;36010968;36241641;36310878;37938771;7479848;7479976;7575604;7628694;7776974;7809113;7831327;7862124;7957109;8387275;8657102;8670417;8816457;8887627;9008162;9038140;9135156;9278383;9315679;9346484;9520401;9689078;9721103;9859996;9865693;9914500;9990852",
        "class_list": "",
        "function": "Inhibits NF-kappa-B by complexing with and trapping it in the cytoplasm. However, the unphosphorylated form resynthesized after cell stimulation is able to bind NF-kappa-B allowing its transport to the nucleus and protecting it to further NFKBIA-dependent inactivation. Association with inhibitor kappa B-interacting NKIRAS1 and NKIRAS2 prevent its phosphorylation rendering it more resistant to degradation, explaining its slower degradation., [UniProtKB]; The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Jul 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 13,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K3F4;Q96BJ7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003713 transcription coactivator activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0007165 signal transduction;GO:0071222 cellular response to lipopolysaccharide",
        "synthesized_glycan_count": 0,
        "hit_score": 12.3,
        "record_id": "Q15653-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y2G0-1",
        "uniprot_id": [
            {
                "id": "EFR3B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y2G0",
                "type": "external"
            }
        ],
        "mass": 92487.0,
        "length": 817,
        "protein_name": "Protein EFR3 homolog B",
        "gene_name": "EFR3B",
        "organism": "Human",
        "refseq_name": "protein EFR3 homolog B isoform 1",
        "refseq_ac": [
            {
                "id": "NP_055786",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055786",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EFR3B; KIAA0953",
        "gene_names_refseq": "EFR3B; KIAA0953",
        "protein_names_uniprotkb": "Protein EFR3 homolog B",
        "protein_names_refseq": "protein EFR3 homolog B isoform 1; protein EFR3 homolog B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:22979)",
        "pathway_count": 1,
        "publication_count": 40,
        "publication_id_list": "11237011;19913121;20628086;23229899;23481700;24366607;25380825;25608530;25645385;26571211;26992070;27397612;27846572;27920218;29331515;29393594;29508533;29557506;29632711;29786170;30379171;30484775;31154438;31844290;32157095;32350084;32488085;33123756;33141586;33298915;33912179;34087483;34171305;34211107;34405274;35051231;35705054;36010968;36215666;37938771",
        "class_list": "",
        "function": "Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3B probably acts as the membrane-anchoring component. Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Observational study of gene-disease association, gene-environment interaction, and pharmacogenomic / toxicogenomic. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; These data suggest that mammalian Efr3s contribute to the control of the phosphorylation state and, hence, desensitization of AT1a receptors, and could affect responsiveness of G-protein-coupled receptors in higher eukaryotes., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
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        "total_reported_o_glycosites": 2,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 1,
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        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7WPL8;Q86XU6",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0046854 phosphatidylinositol phosphate biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.4,
        "record_id": "Q9Y2G0-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7KZ85-1",
        "uniprot_id": [
            {
                "id": "SPT6H_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7KZ85",
                "type": "external"
            }
        ],
        "mass": 199073.0,
        "length": 1726,
        "protein_name": "Transcription elongation factor SPT6",
        "gene_name": "SUPT6H",
        "organism": "Human",
        "refseq_name": "transcription elongation factor SPT6",
        "refseq_ac": [
            {
                "id": "NP_001307684",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307684",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SUPT6H; KIAA0162; SPT6H",
        "gene_names_refseq": "SPT6H; SPT6; SUPT6H; emb-5",
        "protein_names_uniprotkb": "Transcription elongation factor SPT6; Histone chaperone suppressor of Ty6; Tat-CT2 protein; Tat-cotransactivator 2 protein; hSPT6",
        "protein_names_refseq": "histone chaperone suppressor of Ty6; suppressor of Ty 6 homolog; tat-CT2 protein; tat-cotransactivator 2 protein; transcription elongation factor SPT6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:6830);  (R-HSA-112382);  (R-HSA-674695);  (R-HSA-75955)",
        "pathway_count": 4,
        "publication_count": 178,
        "publication_id_list": "10199401;10933715;11237011;11313498;11313499;11859374;11884399;12676794;15060154;15489290;17081983;17234882;17287340;18220336;18452278;18669648;19141475;1939271;19413330;19608861;19651622;19690332;19691289;19952111;20068231;20112406;20159561;20166139;21406692;21518874;21872626;21993680;22171252;22316138;22567361;22645359;23186163;23481700;23503590;23783831;24163256;24275569;24366607;2449431;24714562;24715725;25182531;25367160;25418920;25505266;25576301;25645385;25880248;25892735;26154972;26375851;26659056;26728094;26768311;26811146;26853435;26929215;26992070;27397612;27543614;27600516;27846572;27862975;27920218;28218747;28228285;28446606;28510447;28514659;28649982;28657654;28832583;28834231;28904123;29237092;29242379;29351928;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30059200;30315122;30379171;30410026;30429286;30484775;30620550;30779550;31092671;31217245;31373491;31492838;31844290;32119511;32157095;32265295;32350084;32357974;32387766;32488085;32502341;32574038;32897882;32938616;32983136;33043033;33064988;33091337;33141586;33214551;33298915;33392160;33537174;33542242;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34087483;34146481;34171305;34185709;34233157;34405274;34509645;34561969;34725712;34932366;35051231;35132862;35138101;35254053;35289036;35318648;35513511;35561310;35580925;35705054;36010968;36215666;36241641;36284347;36581221;36852700;37481442;37541260;37938771;38665916;39531497;39534244;39603239;40307207;40914422;7660122;7660129;7660130;8370526;8786132;9450929;9489704;9514752",
        "class_list": "",
        "function": "Histone H3-H4 chaperone that plays a key role in the regulation of transcription elongation and mRNA processing. Enhances the transcription elongation by RNA polymerase II (RNAPII) and is also required for the efficient activation of transcriptional elongation by the HIV-1 nuclear transcriptional activator, Tat. Besides chaperoning histones in transcription, acts to transport and splice mRNA by forming a complex with IWS1 and the C-terminal domain (CTD) of the RNAPII subunit RPB1 (POLR2A). The SUPT6H:IWS1:CTD complex recruits mRNA export factors (ALYREF/THOC4, EXOSC10) as well as histone modifying enzymes (such as SETD2), to ensure proper mRNA splicing, efficient mRNA export and elongation-coupled H3K36 methylation, a signature chromatin mark of active transcription. SUPT6H via its association with SETD1A, regulates both class-switch recombination and somatic hypermutation through formation of H3K4me3 epigenetic marks on activation-induced cytidine deaminase (AICDA) target loci. Promotes the activation of the myogenic gene program by entailing erasure of the repressive H3K27me3 epigenetic mark through stabilization of the chromatin interaction of the H3K27 demethylase KDM6A., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Hypermethylation-Mediated lncRNA MAGI2-AS3 Downregulation Facilitates Malignant Progression of Laryngeal Squamous Cell Carcinoma via Interacting With SPT6., [RefSeq, PubMed]; Insights into Spt6: a histone chaperone that functions in transcription, DNA replication, and genome stability. Review article, [RefSeq, PubMed]; Reults establish that human Spt6 (hSpt6) is a classic transcription elongation factor that enhances the rate of RNA polymerase II elongation., [RefSeq, PubMed]; SPT6 promotes epidermal differentiation and blockade of an intestinal-like phenotype through control of transcriptional elongation. Publication Status: Online-Only, [RefSeq, PubMed]; Targeted protein degradation reveals a direct role of SPT6 in RNAPII elongation and termination., [RefSeq, PubMed]; Two distinct mechanisms of RNA polymerase II elongation stimulation in vivo., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 9,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 9,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 9,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 30,
        "reported_mutagensis": 0,
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        "reported_snv": 51,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7E2B4;Q15737;Q6GMQ4;Q7KYW9;Q7LDK4;Q8N526;Q92775;Q96AH3;Q9BTH9;Q9BTI2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003723 RNA binding;GO:0042393 histone binding;GO:0031491 nucleosome binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex",
        "go_biological_process": "GO:0034728 nucleosome organization;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0045191 regulation of isotype switching;GO:0006368 transcription elongation by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 19.0,
        "record_id": "Q7KZ85-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q49AJ0-1",
        "uniprot_id": [
            {
                "id": "F135B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q49AJ0",
                "type": "external"
            }
        ],
        "mass": 155770.0,
        "length": 1406,
        "protein_name": "Protein FAM135B",
        "gene_name": "FAM135B",
        "organism": "Human",
        "refseq_name": "protein FAM135B",
        "refseq_ac": [
            {
                "id": "NP_056996",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056996",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM135B; C8orfK32",
        "gene_names_refseq": "C8ORFK32; FAM135B",
        "protein_names_uniprotkb": "Protein FAM135B",
        "protein_names_refseq": "protein FAM135B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51059)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "11237011;25576301;27600516;29393594;29557506;29769354;29789417;30391288;31530632;31844290;32357974;32387766;33298915;33323378;33340561;34185709;34509645;35051231;35318648;35580925;36215666",
        "class_list": "",
        "function": "A GRN Autocrine-Dependent FAM135B/AKT/mTOR Feedforward Loop Promotes Esophageal Squamous Cell Carcinoma Progression., [RefSeq, PubMed]; Silencing FAM135B enhances radiosensitivity of esophageal carcinoma cell., [RefSeq, PubMed]; Using microarray analysis reveals novel genes such as FAM135B, dysregulated in Spinal and bulbar muscular atrophy (SBMA). Knockdown of FAM135B results in neurodegeneration, indicating its role in SBMA., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "B5MDB3;O95879;Q2WGJ7;Q3KP46",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0006629 lipid metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q49AJ0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N766-1",
        "uniprot_id": [
            {
                "id": "EMC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N766",
                "type": "external"
            }
        ],
        "mass": 111759.0,
        "length": 993,
        "protein_name": "ER membrane protein complex subunit 1",
        "gene_name": "EMC1",
        "organism": "Human",
        "refseq_name": "ER membrane protein complex subunit 1 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001258356",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258356",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EMC1; KIAA0090; PSEC0263",
        "gene_names_refseq": "CAVIPMR; EMC1; KIAA0090",
        "protein_names_uniprotkb": "ER membrane protein complex subunit 1",
        "protein_names_refseq": "ER membrane protein complex subunit 1 isoform 2 precursor",
        "tax_id": 9606,
        "disease": "cerebellar atrophy, visual impairment, and psychomotor retardation (Disease Ontology:DOID:0081276); intestinal cancer (Disease Ontology:DOID:10155)",
        "pathway": " (hsa:23065)",
        "pathway_count": 1,
        "publication_count": 112,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;16303743;17547437;19159218;20068231;20095854;22119785;22898188;23090970;23105016;23481700;24190977;24714562;24715725;25418920;25576301;25645385;25892735;26154972;26375851;26728094;26768311;26811146;26929215;26942288;26992070;27397612;27452731;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28514659;28832583;28834231;28904123;29242231;29242379;29331515;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29741879;29769354;29786170;29809151;30315122;30415835;30429286;30484775;30524438;31217245;31530632;31611695;31844290;31848261;32092440;32157095;32265295;32350084;32357974;32387766;32439656;32459176;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33968037;33981976;34019948;34171305;34185709;34211107;34357683;34405274;34509645;34725712;34932366;35051231;35154160;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;36581221;37074911;37938771;38665916;40307207",
        "class_list": "",
        "function": "EMC1 is a gene in which either biallelic or monoallelic variants might lead to a syndrome including intellectual disability and preferential degeneration of the cerebellum., [RefSeq, PubMed]; Novel truncating and missense variants extending the spectrum of EMC1-related phenotypes, causing autism spectrum disorder, severe global development delay and visual impairment., [RefSeq, PubMed]; Observational study of gene-disease association and gene-environment interaction. (HuGE Navigator), [RefSeq, PubMed]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; This gene encodes a single-pass type I transmembrane protein, which is a subunit of the endoplasmic reticulum membrane protein complex (EMC). Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
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        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 15,
        "disease_count": 2,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K6F3;Q14700;Q5TG62;Q63HL0;Q63HL3;Q8NBH8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0072546 EMC complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence",
        "synthesized_glycan_count": 0,
        "hit_score": 13.2,
        "record_id": "Q8N766-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y316-1",
        "uniprot_id": [
            {
                "id": "MEMO1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y316",
                "type": "external"
            }
        ],
        "mass": 33733.0,
        "length": 297,
        "protein_name": "Protein MEMO1",
        "gene_name": "MEMO1",
        "organism": "Human",
        "refseq_name": "protein MEMO1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001131074",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131074",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MEMO1; C2orf4; CGI-27; MEMO; NS5ATP7",
        "gene_names_refseq": "C2orf4; CGI-27; MEMO1; MEMO; NS5ATP7",
        "protein_names_uniprotkb": "Protein MEMO1; C21orf19-like protein; HCV NS5A-transactivated protein 7; Hepatitis C virus NS5A-transactivated protein 7; Mediator of ErbB2-driven cell motility 1; Mediator of cell motility 1; Memo-1",
        "protein_names_refseq": "C21orf19-like protein; HCV NS5A-transactivated protein 7; hepatitis C virus NS5A-transactivated protein 7; mediator of ErbB2-driven cell motility 1; protein MEMO1 isoform 2; protein MEMO1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:51072);  (R-HSA-6785631)",
        "pathway_count": 2,
        "publication_count": 59,
        "publication_id_list": "11237011;11707072;15156151;16497976;18045866;18083107;18955552;20068231;20937854;21840311;23481700;24366607;24714562;25576301;25880248;26375851;26728094;26811146;26992070;28218747;28228285;28510447;28514659;28832583;28834231;28904123;29242379;29786170;31020640;31217245;31530632;31844290;32157095;32265295;32357974;32387766;32502341;32938616;32983136;33043033;33298915;33592498;33691108;33912179;33936100;33968037;34019948;34087483;34171305;34561969;34932366;35051231;35154160;36010968;36067318;36215666;36627049;38640016;38665916",
        "class_list": "",
        "function": "2.1A crystal structure and homology to class III nonheme iron-dependent dioxygenases, [RefSeq, PubMed]; Data suggest that Memo controls cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton [Memo], [RefSeq, PubMed]; MEMO1 binds iron and modulates iron homeostasis in cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Is required for breast carcinoma cell migration., [UniProtKB, PubMed, PubMed]; Memo-RhoA-mDia1 signaling coordinates the organization of the lamellipodial actin network, adhesion site formation, and microtubule outgrowth within the cell leading edge to sustain cell motility., [RefSeq, PubMed]; Memo1 binds reduced copper ions, interacts with copper chaperone Atox1, and protects against copper-mediated redox activity in vitro., [RefSeq, PubMed]; WD repeat protein 54-mediator of ErbB2-driven cell motility 1 axis promotes bladder cancer tumorigenesis and metastasis and impairs chemosensitivity., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 4,
        "reported_mutagensis": 6,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DLS0;D6W575;Q5R2V8;Q5R2V9;Q6NSL5",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol",
        "go_biological_process": "GO:0032886 regulation of microtubule-based process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.2,
        "record_id": "Q9Y316-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8NFI3-1",
        "uniprot_id": [
            {
                "id": "ENASE_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8NFI3",
                "type": "external"
            }
        ],
        "mass": 83987.0,
        "length": 743,
        "protein_name": "Cytosolic endo-beta-N-acetylglucosaminidase",
        "gene_name": "ENGASE",
        "organism": "Human",
        "refseq_name": "cytosolic endo-beta-N-acetylglucosaminidase isoform 4",
        "refseq_ac": [
            {
                "id": "NP_001036038",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001036038",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ENGASE",
        "gene_names_refseq": "ENGASE",
        "protein_names_uniprotkb": "Cytosolic endo-beta-N-acetylglucosaminidase; 3.2.1.96; ENGase",
        "protein_names_refseq": "Di-N-acetylchitobiosyl beta-N-acetylglucosaminidase; Mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase; cytosolic endo-beta-N-acetylglucosaminidase isoform 4; cytosolic endo-beta-N-acetylglucosaminidase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64772);  (R-HSA-532668)",
        "pathway_count": 2,
        "publication_count": 34,
        "publication_id_list": "10788335;10929008;11237011;12114544;12145188;12905469;15215856;15358861;15362974;16055502;16168377;18524852;18586680;19690332;21873561;23186163;24275569;25576301;26611529;29351928;29557506;30429286;31844290;32387766;32897882;33592498;33730571;33912179;33981976;34171305;34397265;35051231;35580925;36010968",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "Endo-beta-n-acetylglucosaminidase present in the synovial fluid of rheumatoid arthritis patients, may contribute to the depletion of glycosaminoglycans from cartilage allowing the invasion of synovial cells, [RefSeq, PubMed]; Endoglycosidase that releases N-glycans from glycoproteins by cleaving the beta-1,4-glycosidic bond in the N,N'-diacetylchitobiose core. Involved in the processing of free oligosaccharides in the cytosol., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Identification of O-GlcNAcase as a caspase-3 substrate with a novel caspase-3 cleavage site and provide insight about O-GlcNAcase regulation during apoptosis., [RefSeq, PubMed]; Involved in processing of free oligosaccharides in the cytosol; identification of the gene encoding human cytosolic ENGase, [RefSeq, PubMed]; N-acetyl-ss-D-glucosaminidase is predictive of mortality in chronic heart failure: a 10-year follow-up., [RefSeq, PubMed]; Serological N-acetyl-glucosaminidase, telomere length, and the UCP2-886G>A variant are independent risk factors for type 2 diabetes., [RefSeq, PubMed]; This gene encodes a cytosolic enzyme which catalyzes the hydrolysis of peptides and proteins with mannose modifications to produce free oligosaccharides. [provided by RefSeq, Feb 2012]., [RefSeq]; Transcriptome-wide association study reveals two genes that influence mismatch negativity., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1019,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q659F0;Q8TB86;Q9H6U4",
        "ec_number_list": [
            {
                "id": "3.2.1.96",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.96",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0033925 mannosyl-glycoprotein endo-beta-N-acetylglucosaminidase activity",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0006457 protein folding;GO:0006491 N-glycan processing",
        "synthesized_glycan_count": 0,
        "hit_score": 3.7,
        "record_id": "Q8NFI3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.10100",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P26378-6",
        "uniprot_id": [
            {
                "id": "ELAV4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P26378",
                "type": "external"
            }
        ],
        "mass": 42398.0,
        "length": 385,
        "protein_name": "ELAV-like protein 4",
        "gene_name": "ELAVL4",
        "organism": "Human",
        "refseq_name": "ELAV-like protein 4 isoform 9",
        "refseq_ac": [
            {
                "id": "NP_001311142",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311142",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ELAVL4; HUD; PNEM",
        "gene_names_refseq": "ELAVL4; HUD; PNEM",
        "protein_names_uniprotkb": "ELAV-like protein 4; Hu-antigen D; HuD; Paraneoplastic encephalomyelitis antigen HuD",
        "protein_names_refseq": "ELAV (embryonic lethal, abnormal vision, Drosophila)-like 4 (Hu antigen D); ELAV like neuron-specific RNA binding protein 4; ELAV-like protein 4 isoform 9; ELAV-like protein 4; paraneoplastic encephalomyelitis antigen HuD",
        "tax_id": 9606,
        "disease": "sciatic neuropathy (Disease Ontology:DOID:11446); hypothyroidism (Disease Ontology:DOID:1459); status epilepticus (Disease Ontology:DOID:1824); learning disability (Disease Ontology:DOID:8927)",
        "pathway": " (hsa:1996)",
        "pathway_count": 1,
        "publication_count": 27,
        "publication_id_list": "10710437;11175903;12034726;12209604;12468554;16508003;1655278;17035636;17234598;18218628;21088113;21389246;22387028;24857657;25892735;29061699;29557506;31154438;34314701;34471224;35843356;36215666;36284347;36498933;37676718;37938771;7898713",
        "class_list": "",
        "function": "ALS-related FUS mutations alter axon growth in motoneurons and affect HuD/ELAVL4 and FMRP activity. Publication Status: Online-Only, [RefSeq, PubMed]; ELAVL4 promotes the tumorigenesis of small cell lung cancer by stabilizing LncRNA LYPLAL1-DT and enhancing profilin 2 activation., [RefSeq, PubMed]; ELAVL4, splicing, and glutamatergic dysfunction precede neuron loss in MAPT mutation cerebral organoids., [RefSeq, PubMed]; Emerging Roles for the RNA-Binding Protein HuD (ELAVL4) in Nervous System Diseases. Review article Publication Status: Online-Only, [RefSeq, PubMed]; RNA-binding protein ELAVL4/HuD ameliorates Alzheimer's disease-related molecular changes in human iPSC-derived neurons., [RefSeq, PubMed]; RNA-binding protein that is involved in the post-transcriptional regulation of mRNAs (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Plays a role in the regulation of mRNA stability, alternative splicing and translation (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:17035636, PubMed:17234598, PubMed:7898713). Binds to AU-rich element (ARE) sequences in the 3' untranslated region (UTR) of target mRNAs, including GAP43, VEGF, FOS, CDKN1A and ACHE mRNA (PubMed:10710437, PubMed:12034726, PubMed:12468554, PubMed:7898713). Many of the target mRNAs are coding for RNA-binding proteins, transcription factors and proteins involved in RNA processing and/or neuronal development and function (By similarity). By binding to the mRNA 3'UTR, decreases mRNA deadenylation and thereby contributes to the stabilization of mRNA molecules and their protection from decay (PubMed:12034726). Also binds to the polyadenylated (poly(A)) tail in the 3'UTR of mRNA, thereby increasing its affinity for mRNA binding (PubMed:12034726). Mainly plays a role in neuron-specific RNA processing by stabilization of mRNAs such as GAP43, ACHE and mRNAs of other neuronal proteins, thereby contributing to the differentiation of neural progenitor cells, nervous system development, learning and memory mechanisms (PubMed:12034726, PubMed:12468554, PubMed:17234598, PubMed:18218628). Involved in the negative regulation of the proliferative activity of neuronal stem cells and in the positive regulation of neuronal differentiation of neural progenitor cells (By similarity). Promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone of the hippocampus by binding to and stabilizing SATB1 mRNA (By similarity). Binds and stabilizes MSI1 mRNA in neural stem cells (By similarity). Exhibits increased binding to ACHE mRNA during neuronal differentiation, thereby stabilizing ACHE mRNA and enhancing its expression (PubMed:12468554, PubMed:17234598). Protects CDKN1A mRNA from decay by binding to its 3'-UTR (By similarity). May bind to APP and BACE1 mRNAS and the BACE1AS lncRNA and enhance their stabilization (PubMed:24857657). Plays a role in neurite outgrowth and in the establishment and maturation of dendritic arbors, thereby contributing to neocortical and hippocampal circuitry function (By similarity). Stabilizes GAP43 mRNA and protects it from decay during postembryonic development in the brain (PubMed:12034726). By promoting the stabilization of GAP43 mRNA, plays a role in NGF-mediated neurite outgrowth (By similarity). Binds to BDNF long 3'UTR mRNA, thereby leading to its stabilization and increased dendritic translation after activation of PKC (By similarity). By increasing translation of BDNF after nerve injury, may contribute to nerve regeneration (By similarity). Acts as a stabilizing factor by binding to the 3'UTR of NOVA1 mRNA, thereby increasing its translation and enhancing its functional activity in neuron-specific splicing (PubMed:18218628). Stimulates translation of mRNA in a poly(A)- and cap-dependent manner, possibly by associating with the EIF4F cap-binding complex (By similarity). May also negatively regulate translation by binding to the 5'UTR of Ins2 mRNA, thereby repressing its translation (By similarity). Upon glucose stimulation, Ins2 mRNA is released from ELAVL4 and translational inhibition is abolished (By similarity). Also plays a role in the regulation of alternative splicing (PubMed:17035636). May regulate alternative splicing of CALCA pre-mRNA into Calcitonin and Calcitonin gene-related peptide 1 (CGRP) by competing with splicing regulator TIAR for binding to U-rich intronic sequences of CALCA pre-mRNA (PubMed:17035636)., [UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 4,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1APY6;B1APY7;B1APY8;B7Z4G7;Q8IYD4;Q96J74;Q96J75;Q9UD24",
        "ec_number_list": [],
        "go_molecular_function": "GO:0097158 pre-mRNA intronic pyrimidine-rich binding;GO:0003730 mRNA 3'-UTR binding;GO:0008143 poly(A) binding;GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0140517 protein-RNA adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0030424 axon;GO:0030425 dendrite;GO:0030426 growth cone;GO:0043204 perikaryon",
        "go_biological_process": "GO:0006396 RNA processing;GO:0006397 mRNA processing;GO:0008380 RNA splicing;GO:0070935 3'-UTR-mediated mRNA stabilization;GO:1905870 positive regulation of 3'-UTR-mediated mRNA stabilization",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "P26378-6",
        "record_type": "protein",
        "filter_code": "0000000.0000111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IZ81-1",
        "uniprot_id": [
            {
                "id": "ELMD2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IZ81",
                "type": "external"
            }
        ],
        "mass": 34961.0,
        "length": 293,
        "protein_name": "ELMO domain-containing protein 2",
        "gene_name": "ELMOD2",
        "organism": "Human",
        "refseq_name": "ELMO domain-containing protein 2",
        "refseq_ac": [
            {
                "id": "NP_714913",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_714913",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ELMOD2",
        "gene_names_refseq": "9830169G11Rik; ELMOD2",
        "protein_names_uniprotkb": "ELMO domain-containing protein 2",
        "protein_names_refseq": "ELMO domain-containing protein 2; ELMO/CED-12 domain containing 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:255520)",
        "pathway_count": 1,
        "publication_count": 28,
        "publication_id_list": "11237011;16773575;17452337;19966137;23481700;24616099;26811146;26992070;28218747;28832583;28904123;29393594;29437277;29632046;30315122;30865555;31844290;32157095;32265295;32350084;32357974;32938616;33592498;34185709;38253038;38665916;38838015;40596516",
        "class_list": "",
        "function": "Acts as a GTPase-activating protein (GAP) toward guanine nucleotide exchange factors like ARL2, ARL3, ARF1 and ARF6, but not for GTPases outside the Arf family. Regulates IFN-related antiviral responses., [UniProtKB, PubMed, PubMed]; Results describe the purification from bovine testis of an Arl2 GAP and its identity as ELMOD2, a protein with no previously described function., [RefSeq, PubMed]; Results suggest ELMOD2 as a novel candidate gene for susceptibility in familial idiopathic pulmonary fibrosis, [RefSeq, PubMed]; Results suggest that ELMOD2 is functioning as an effector downstream of ARL2 and upstream of the mitofusins to promote mitochondrial fusion. Data provide insights into the pathway by which mitochondrial fusion is regulated in the cell., [RefSeq, PubMed]; TLR3 pathway is dependent on ELMOD2, [RefSeq, PubMed]; The non-opioid sigma-1 receptor (S1R) was identified as a novel effector of GAP activity of ELMOD1-3 proteins as its direct binding to either ELMOD1 or ELMOD2 resulted in loss of GAP activity., [RefSeq, PubMed]; This gene encodes one of six engulfment and motility (ELMO) domain-containing proteins. This gene is thought to play a role in antiviral responses. Mutations in this gene may be involved in the cause of familial idiopathic pulmonary fibrosis. [provided by RefSeq, Sep 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R712;D3DNZ0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005096 GTPase activator activity",
        "go_cellular_component": "GO:0016020 membrane",
        "go_biological_process": "GO:0051607 defense response to virus;GO:0050688 regulation of defense response to virus",
        "synthesized_glycan_count": 0,
        "hit_score": 3.3,
        "record_id": "Q8IZ81-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O76062-1",
        "uniprot_id": [
            {
                "id": "ERG24_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O76062",
                "type": "external"
            }
        ],
        "mass": 46406.0,
        "length": 418,
        "protein_name": "Delta(14)-sterol reductase TM7SF2",
        "gene_name": "TM7SF2",
        "organism": "Human",
        "refseq_name": "delta(14)-sterol reductase TM7SF2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001264162",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001264162",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TM7SF2; ANG1",
        "gene_names_refseq": "ANG1; C14SR; DHCR14A; NET47; TM7SF2",
        "protein_names_uniprotkb": "Delta(14)-sterol reductase TM7SF2; 1.3.1.70; 3-beta-hydroxysterol Delta (14)-reductase; Another new gene 1 protein; C-14 sterol reductase; C14SR; Delta-14-SR; Putative sterol reductase SR-1; Sterol C14-reductase; Transmembrane 7 superfamily member 2",
        "protein_names_refseq": "3-beta-hydroxysterol Delta (14)-reductase; C-14 sterol reductase; another new gene 1 protein; delta(14)-sterol reductase TM7SF2 isoform 2; delta(14)-sterol reductase TM7SF2; delta-14-SR; putative sterol reductase SR-1; sterol C14-reductase",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7108);  (R-HSA-2426168);  (R-HSA-6807047);  (R-HSA-6807062)",
        "pathway_count": 4,
        "publication_count": 92,
        "publication_id_list": "10369263;10391218;10391219;10400691;10759542;11237011;11414710;11519011;11937680;12083769;12177166;12189593;12618959;12764144;12812989;12829805;1377680;14404284;14506130;16784888;17449569;17925399;18559965;18654640;18682402;18726356;1968462;19940018;20138239;20450493;20719759;20937905;21285510;22634312;23050906;24715725;25418920;25892735;26154972;26811146;26992070;27600516;27920218;28228285;28832583;28834231;29242379;29393594;29557506;29769354;30315122;30524438;31154438;31530632;31844290;31848261;31911440;32157095;32265295;32387766;32897882;32938616;33691108;33912179;33968037;34171305;34509645;34932366;35051231;35580925;36010968;7567999;7592729;7732023;7909540;8020941;8619637;8626466;8626488;8647822;8663358;8663599;8797093;8798690;8976377;9099716;9465114;9604010;9615229;9634533;9748295;9878250",
        "class_list": "",
        "function": "Catalyzes the reduction of the C14-unsaturated bond of lanosterol, as part of the metabolic pathway leading to cholesterol biosynthesis., [UniProtKB, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; Data suggest that, besides the SRE motif, both the inverted CCAAT-box and GC-box2 are essential for full TM7SF2 promoter activation by SREBP-2., [RefSeq, PubMed]; LBR mutant variants and sterol reductases can severely interfere with the regular organization of the nuclear envelope and the endoplasmic reticulum., [RefSeq, PubMed]; Results show that the TM7SF2 gene product SR-1 and six chimeras containing SR-1 and Neurospora erg-3 sequences fail to complement sterol c-14 reductase mutants in Neurospora and yeast., [RefSeq, PubMed]; Twin enzymes, divergent control: The cholesterogenic enzymes DHCR14 and LBR are differentially regulated transcriptionally and post-translationally., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "reported_phosphosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "secondary_ac_list": "A8K4H0;O95982;Q8IY06;Q96E64;Q96GZ1",
        "ec_number_list": [
            {
                "id": "1.3.1.70",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.70",
                "type": "external"
            },
            {
                "id": "1.3.1.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.3.1.21",
                "type": "external"
            },
            {
                "id": "3.3.2.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.11",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0050661 NADP binding;GO:0050613 Delta14-sterol reductase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane;GO:0043235 receptor complex;GO:0005789 endoplasmic reticulum membrane;GO:0005637 nuclear inner membrane",
        "go_biological_process": "GO:0006695 cholesterol biosynthetic process;GO:0033490 cholesterol biosynthetic process via lathosterol",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "O76062-1",
        "record_type": "protein",
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        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15022-1",
        "uniprot_id": [
            {
                "id": "SUZ12_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15022",
                "type": "external"
            }
        ],
        "mass": 83055.0,
        "length": 739,
        "protein_name": "Polycomb protein SUZ12",
        "gene_name": "SUZ12",
        "organism": "Human",
        "refseq_name": "polycomb protein SUZ12 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_056170",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056170",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SUZ12; CHET9; JJAZ1; KIAA0160",
        "gene_names_refseq": "CHET9; IMMAS; JJAZ1; SUZ12",
        "protein_names_uniprotkb": "Polycomb protein SUZ12; ChET 9 protein; Chromatin precipitated E2F target 9 protein; Joined to JAZF1 protein; Suppressor of zeste 12 protein homolog",
        "protein_names_refseq": "chET 9 protein; chromatin precipitated E2F target 9 protein; joined to JAZF1 protein; polycomb protein SUZ12 isoform 1; polycomb protein SUZ12; suppressor of zeste 12 protein homolog",
        "tax_id": 9606,
        "disease": "spina bifida (Disease Ontology:DOID:0080016); renal Wilms' tumor (Disease Ontology:DOID:5176); Imagawa-Matsumoto syndrome (MONDO:MONDO:0032916)",
        "pathway": " (hsa:23512);  (R-HSA-212300);  (R-HSA-2559580);  (R-HSA-3214841);  (R-HSA-4551638);  (R-HSA-5617472);  (R-HSA-8943724);  (R-HSA-8953750);  (R-HSA-9609690);  (R-HSA-9710421);  (R-HSA-9764725);  (R-HSA-9909649)",
        "pathway_count": 12,
        "publication_count": 371,
        "publication_id_list": "10.1101/2023.09.13.557529;10347217;10655587;10722742;10772813;10777502;10871633;10949293;11171983;11237011;11371647;11378386;11545734;11564866;11781575;11912130;11959841;11959846;11960997;12004135;12032081;12123582;12130538;12134156;12189133;12193592;12351676;12421820;12435631;12453418;12540855;12670868;12700765;12808055;12857923;12909625;13130464;14507994;14532106;14536086;14578449;14690610;14701874;14992727;15014447;15099518;15145825;15199155;15225548;15231737;15235609;15287722;15385962;15536069;15542832;15563468;15592428;15684044;15866172;15867264;15964846;16079151;16118227;16140760;16186825;16199523;16224021;16292313;16337592;16357870;16418168;16431907;16436515;16519522;16549775;16618801;16676006;16682010;16702404;16712789;16805913;16826196;17001316;17018294;17021013;17081983;17130829;17185360;17200670;17210787;17254968;17255097;17322306;17332741;17344414;17395714;17428788;17500065;17544230;1756725;17600109;17660710;17693683;17707229;17713478;17761849;17765224;17825402;17851529;17873065;17875933;17974977;18086877;18172008;18172012;18203656;18220336;18223688;18285464;18346456;18365017;18391013;18408014;18452278;18487508;18535146;18562691;18628979;18669648;18691969;18767875;18772439;18781158;18793328;18974356;19007248;19026781;19088198;19115252;19232136;19413330;19440552;19451217;19451218;19462008;19528227;19571010;19651622;19664995;19682613;19690332;19691289;19747919;1975088;19782034;19808676;19854132;19884659;20068231;20075857;20085832;20098713;20112406;20123894;20233713;20351170;20417598;20418909;20516213;20871592;20937877;20974918;21131967;21170310;21196496;21289308;21406692;21596310;21690215;21779408;21832073;21872626;21986495;22009739;22020331;22099308;22128185;22158034;22174689;22323599;22325352;22336108;22402492;22466170;22493095;22569366;22645359;22683641;22705304;22879880;22939622;23186163;23219899;23287862;23326524;23431328;23466526;23481700;23534758;23630040;23679895;23750026;23954429;24068740;24074865;24129315;24174538;24312487;24369422;24586203;24627085;24714562;24715725;24718924;24782567;25101834;25135475;25391492;25418920;25576301;25645385;25704882;2570724;25728608;25728771;25810538;25892735;25913784;26154972;26212009;26375851;26572645;26728094;26811146;26910647;26929215;26992070;27068747;27501258;27846572;27920218;28063628;28229514;28352266;28404884;28415052;28649982;28832583;28834231;28904123;29242379;29351928;29393594;29493099;29499137;29508533;29557506;29632046;29632711;29729076;29769354;30019515;30026490;30315122;30360396;30379171;30385408;30429286;30484775;30524438;30761409;30898548;30923826;30993897;31086175;31217245;31736240;31844290;31959557;32157095;32183950;32188940;32357974;32387766;32488085;32502341;32860047;32897882;32938616;32983136;33141586;33298915;33537174;33592498;33608512;33633747;33691108;33717175;33912179;33968037;33981976;34078123;34087483;34171305;34211107;34509645;34932366;35008676;35051231;35083852;35138000;35292107;35561310;35580925;35851744;36010968;36215666;36241641;36919607;37217939;37938771;37967992;39400513;40596516;7488013;7501971;7535770;7588633;7623816;7816143;7831296;7859739;7906964;7908827;8001816;8078588;8259215;8319905;8622669;8622688;8626550;8674428;8741839;8759021;8774846;8846784;8974401;9030721;9162092;9195981;9218805;9272954;9482740;9501179;9529249;9564042;9628874;9689056;9704927;9768359;9824166",
        "class_list": "",
        "function": "An investigation of the etiology and follow-up findings in 35 children with overgrowth syndromes, including biallelic SUZ12 variant., [RefSeq, PubMed]; Circ-SUZ12 Protects Cardiomyocytes from Hypoxia-Induced Dysfunction Through Upregulating SUZ12 Expression to Activate Wnt/beta-catenin Signaling Pathway., [RefSeq, PubMed]; Polycomb group (PcG) protein. Component of the PRC2 complex, which methylates 'Lys-9' (H3K9me) and 'Lys-27' (H3K27me) of histone H3, leading to transcriptional repression of the affected target gene (PubMed:15225548, PubMed:15231737, PubMed:15385962, PubMed:16618801, PubMed:17344414, PubMed:18285464, PubMed:28229514, PubMed:29499137, PubMed:31959557). The PRC2 complex may also serve as a recruiting platform for DNA methyltransferases, thereby linking two epigenetic repression systems (PubMed:12351676, PubMed:12435631, PubMed:15099518, PubMed:15225548, PubMed:15385962, PubMed:15684044, PubMed:16431907, PubMed:18086877, PubMed:18285464). Genes repressed by the PRC2 complex include HOXC8, HOXA9, MYT1 and CDKN2A (PubMed:15231737, PubMed:16618801, PubMed:17200670, PubMed:31959557)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; The expression and role of SUZ12 in lung adenocarcinoma., [RefSeq, PubMed]; This zinc finger gene has been identified at the breakpoints of a recurrent chromosomal translocation reported in endometrial stromal sarcoma. Recombination of these breakpoints results in the fusion of this gene and JAZF1. The protein encoded by this gene contains a zinc finger domain in the C terminus of the coding region. [provided by RefSeq, Jul 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 12,
        "reported_mutagensis": 6,
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        "reported_snv": 30,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96BD9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008047 enzyme activator activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0031490 chromatin DNA binding;GO:1990841 promoter-specific chromatin binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0016604 nuclear body;GO:0035098 ESC/E(Z) complex",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0045596 negative regulation of cell differentiation;GO:0031507 heterochromatin formation;GO:0140718 facultative heterochromatin formation",
        "synthesized_glycan_count": 0,
        "hit_score": 37.6,
        "record_id": "Q15022-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P34913-1",
        "uniprot_id": [
            {
                "id": "HYES_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P34913",
                "type": "external"
            }
        ],
        "mass": 62616.0,
        "length": 555,
        "protein_name": "Bifunctional epoxide hydrolase 2",
        "gene_name": "EPHX2",
        "organism": "Human",
        "refseq_name": "bifunctional epoxide hydrolase 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001243411",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243411",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPHX2",
        "gene_names_refseq": "ABHD20; CEH; EPHX2; SEH",
        "protein_names_uniprotkb": "Bifunctional epoxide hydrolase 2; Epoxide hydratase; SEH; Soluble epoxide hydrolase",
        "protein_names_refseq": "bifunctional epoxide hydrolase 2 isoform 2; bifunctional epoxide hydrolase 2; epoxide hydratase; epoxide hydrolase 2, cytoplasmic; epoxide hydrolase 2, cytosolic; epoxide hydrolase, soluble",
        "tax_id": 9606,
        "disease": "stroke (Disease Ontology:DOID:0051061); dystonia 33 (Disease Ontology:DOID:0060940); Alzheimer's disease (Disease Ontology:DOID:10652); hypertension (Disease Ontology:DOID:10763); hypertrophic cardiomyopathy (Disease Ontology:DOID:11984); Huntington's disease (Disease Ontology:DOID:12858); familial hypercholesterolemia (Disease Ontology:DOID:13810); Parkinson's disease (Disease Ontology:DOID:14330); hepatitis B (Disease Ontology:DOID:2043); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); pulmonary venoocclusive disease (Disease Ontology:DOID:5453); pulmonary hypertension (Disease Ontology:DOID:6432)",
        "pathway": " (hsa:2053);  (R-HSA-2142670);  (R-HSA-9018682);  (R-HSA-9033241)",
        "pathway_count": 4,
        "publication_count": 106,
        "publication_id_list": "10022913;10562279;10673331;10862610;11101887;11237011;11546814;11781871;11931631;12456682;12468260;12559034;12574508;12574510;12578380;12717447;12869654;12885776;15096040;15196990;15258110;15545321;15858711;16322563;16854980;17007944;17726030;18359941;18712838;19103881;19197237;19208625;19584060;19608861;19632994;19746975;19969453;20178365;20934334;21164107;21217101;21554508;21976670;21980954;22002062;22057399;22217705;22371489;22387545;22747494;22798687;23481700;23963456;24235149;24865970;25016021;25036362;25505266;25538232;25854684;26086376;26138649;26220973;26344566;27597759;28063628;28521612;28611990;28765278;28787099;28832583;28860189;29242379;29393594;29557506;29632046;30192525;30379171;31530632;31848261;32502341;32983136;33691108;35051231;35494241;35580925;36636821;38013165;39197248;7625847;7719337;7790377;8342951;8619856;8631948;8824437;8858165;8991089;9090381;9090382;9090383;9539740;9653144;9668159;9837948;9866708",
        "class_list": "",
        "function": "Bifunctional enzyme (PubMed:12574510). The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12574510, PubMed:12869654, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady-state levels of physiological mediators (PubMed:12574510, PubMed:12869654, PubMed:21217101, PubMed:22798687)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Bifunctional enzyme (PubMed:12574510). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid (PubMed:12574510). Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates (PubMed:22217705, PubMed:22387545)., [UniProtKB, PubMed, PubMed, PubMed]; Bifunctional enzyme. The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides. Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides. Also determines steady-state levels of physiological mediators., [UniProtKB, UniProtKB, UniProtKB]; Bifunctional enzyme. The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10-phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10-phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z-enoic acid and 12-phosphonooxy-octadec-9E-enoic acid. Has phosphatase activity toward lyso-glycerophospholipids with also some lower activity toward lysolipids of sphingolipid and isoprenoid phosphates., [UniProtKB, UniProtKB, UniProtKB]; Role of soluble epoxide hydrolase in the abnormal activation of fibroblast-like synoviocytes from patients with rheumatoid arthritis., [RefSeq, PubMed]; Targeting soluble epoxide hydrolase promotes osteogenic-angiogenic coupling via activating SLIT3/HIF-1alpha signalling pathway., [RefSeq, PubMed]; Targeting the soluble epoxide hydrolase pathway as a novel therapeutic approach for the treatment of pain. Review article, [RefSeq, PubMed]; This gene encodes a member of the epoxide hydrolase family. The protein, found in both the cytosol and peroxisomes, binds to specific epoxides and converts them to the corresponding dihydrodiols. Mutations in this gene have been associated with familial hypercholesterolemia. Alternatively spliced transcript variants have been described. [provided by RefSeq, Feb 2012]., [RefSeq]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "B2Z3B1;B3KTU8;B3KUA0;G3V134;J3KPH7;Q16764;Q9HBJ1;Q9HBJ2",
        "ec_number_list": [
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "3.1.3.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.4",
                "type": "external"
            },
            {
                "id": "3.1.3.106",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.106",
                "type": "external"
            },
            {
                "id": "3.6.1.75",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.75",
                "type": "external"
            },
            {
                "id": "3.3.2.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9",
                "type": "external"
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            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.3.2.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10",
                "type": "external"
            },
            {
                "id": "3.1.3.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0052642 lysophosphatidic acid phosphatase activity;GO:0000287 magnesium ion binding;GO:0015643 toxic substance binding;GO:0042803 protein homodimerization activity;GO:0004301 epoxide hydrolase activity",
        "go_cellular_component": "GO:0005777 peroxisome;GO:0005782 peroxisomal matrix;GO:0005829 cytosol;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0016311 dephosphorylation;GO:0010628 positive regulation of gene expression;GO:0090181 regulation of cholesterol metabolic process;GO:0042632 cholesterol homeostasis;GO:0001558 regulation of cell growth",
        "synthesized_glycan_count": 0,
        "hit_score": 10.9,
        "record_id": "P34913-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WW01-1",
        "uniprot_id": [
            {
                "id": "SEN15_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WW01",
                "type": "external"
            }
        ],
        "mass": 18641.0,
        "length": 171,
        "protein_name": "tRNA-splicing endonuclease subunit Sen15",
        "gene_name": "TSEN15",
        "organism": "Human",
        "refseq_name": "tRNA-splicing endonuclease subunit Sen15 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001120866",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001120866",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TSEN15; C1orf19; SEN15",
        "gene_names_refseq": "C1orf19; PCH2F; TSEN15; sen15",
        "protein_names_uniprotkb": "tRNA-splicing endonuclease subunit Sen15; HsSEN15; SEN15 homolog; tRNA-intron endonuclease Sen15",
        "protein_names_refseq": "TSEN15 tRNA splicing endonuclease subunit; tRNA splicing endonuclease 15 homolog; tRNA-intron endonuclease Sen15; tRNA-splicing endonuclease subunit Sen15 isoform 2; tRNA-splicing endonuclease subunit Sen15",
        "tax_id": 9606,
        "disease": "pontocerebellar hypoplasia type 2F (Disease Ontology:DOID:0112329)",
        "pathway": " (hsa:116461);  (R-HSA-6784531)",
        "pathway_count": 2,
        "publication_count": 83,
        "publication_id_list": "10444065;11237011;11318611;11455963;11727826;11871657;12138183;12526808;12711671;12729736;15109492;15317868;16361254;16710424;17166513;17204286;17224653;18226598;18809514;18984158;21311021;21450806;21559454;21593607;22424782;22944664;23186163;23481700;2470644;24715725;24870230;24944287;25558065;25576301;25640237;25849199;26154972;27392077;27600516;27862975;28218747;28228285;28510447;28832583;28860189;28904123;29242379;29557506;30524438;31154438;31222486;31844290;31848261;32157095;32357974;32387766;32488085;32502341;32897882;32938616;33141586;33298915;33392160;33537174;33592498;33691108;33968037;33981976;34211107;34405274;34509645;34584079;35132862;35580925;35705054;36010968;36284347;37938771;6930639;7759547;7828588;9512417;9660920",
        "class_list": "",
        "function": "A candidate SNP associated with the tRNA-splicing protein gene TSEN15 was independently associated with the risk of atrial fibrillation., [RefSeq, PubMed]; Assembly defects of human tRNA splicing endonuclease contribute to impaired pre-tRNA processing in pontocerebellar hypoplasia. Publication Status: Online-Only, [RefSeq, PubMed]; Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini (PubMed:15109492, PubMed:27392077). There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. The tRNA splicing endonuclease is also involved in mRNA processing via its association with pre-mRNA 3'-end processing factors, establishing a link between pre-tRNA splicing and pre-mRNA 3'-end formation, suggesting that the endonuclease subunits function in multiple RNA-processing events (PubMed:15109492)., [UniProtKB, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB]; Results demonstrate that mutations in any known subunit of the TSEN complex can cause pontocerebellar hypoplasia and progressive microcephaly, emphasizing the importance of its function during brain development Erratum:[Am J Hum Genet. 2016 Sep 1;99(3):785. doi: 10.1016/j.ajhg.2016.08.009. PMID: 27588454], [RefSeq, PubMed]; This gene encodes a subunit of the tRNA splicing endonuclease, which catalyzes the removal of introns from tRNA precursors. Alternative splicing results in multiple transcript variants. There is a pseudogene of this gene on chromosome 17. [provided by RefSeq, Jul 2014]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DKP0;Q9BZQ5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003676 nucleic acid binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005634 nucleus",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0000379 tRNA-type intron splice site recognition and cleavage;GO:0006388 tRNA splicing, via endonucleolytic cleavage and ligation",
        "synthesized_glycan_count": 0,
        "hit_score": 8.7,
        "record_id": "Q8WW01-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5T9C2-1",
        "uniprot_id": [
            {
                "id": "EEIG1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5T9C2",
                "type": "external"
            }
        ],
        "mass": 41785.0,
        "length": 384,
        "protein_name": "Early estrogen-induced gene 1 protein",
        "gene_name": "EEIG1",
        "organism": "Human",
        "refseq_name": "early estrogen-induced gene 1 protein isoform a",
        "refseq_ac": [
            {
                "id": "NP_001030331",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001030331",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EEIG1; C9orf132; FAM102A",
        "gene_names_refseq": "C9orf132; EEIG1; FAM102A; SYM-3A; bA203J24.7",
        "protein_names_uniprotkb": "Early estrogen-induced gene 1 protein; EEIG1",
        "protein_names_refseq": "early estrogen-induced gene 1 protein isoform a; early estrogen-induced gene 1 protein; family with sequence similarity 102 member A; protein FAM102A; sym-3 homolog A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:399665)",
        "pathway_count": 1,
        "publication_count": 24,
        "publication_id_list": "14605097;19901323;23478294;23481700;25576301;28832583;28904123;29242379;29310965;29485866;29557506;30429286;31844290;31998317;32157095;32938616;33141586;33592498;33968037;34087483;34171305;35051231;35580925;36241641",
        "class_list": "",
        "function": "A novel estrogen-responsive gene was identified and named EEIG1 for early estrogen-induced gene 1, [RefSeq, PubMed]; EEIG1 is a novel RANK signaling component controlling RANK-mediated osteoclast formation., [RefSeq, PubMed]; In this study, 2 of 8 (primary angle-closure glaucoma) PACG-associated loci were associated significantly with PACS status, the earliest stage in the angle-closure glaucoma disease course. The association of these PACG loci with PACS status suggests that these loci may confer susceptibility to a narrow angle configuration., [RefSeq, PubMed]; Key component of TNFSF11/RANKL- and TNF-induced osteoclastogenesis pathways, thereby mediates bone resorption in pathological bone loss conditions (By similarity). Required for TNFSF11/RANKL-induced osteoclastogenesis via its interaction with TNFRSF11A/RANK, thereby facilitates the downstream transcription of NFATC1 and activation of PLCG2 (By similarity). Facilitates recruitment of the transcriptional repressor PRDM1/BLIMP1 to the promoter of the anti-osteoclastogenesis gene IRF8, thereby resulting in transcription of osteoclast differentiation factors (By similarity). May play a role in estrogen action (PubMed:14605097)., [UniProtKB, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A329;Q8TEL4",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0045121 membrane raft",
        "go_biological_process": "GO:0045672 positive regulation of osteoclast differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.7,
        "record_id": "Q5T9C2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P10070-5",
        "uniprot_id": [
            {
                "id": "GLI2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P10070",
                "type": "external"
            }
        ],
        "mass": 167783.0,
        "length": 1586,
        "protein_name": "Transcription activator GLI2",
        "gene_name": "GLI2",
        "organism": "Human",
        "refseq_name": "zinc finger protein GLI2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_005261",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005261",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "GLI2; THP",
        "gene_names_refseq": "CJS; GLI2; HPE9; PHS2; THP1; THP2",
        "protein_names_uniprotkb": "Transcription activator GLI2; GLI family zinc finger protein 2; Tax helper protein",
        "protein_names_refseq": "GLI family zinc finger protein 2; GLI-Kruppel family member GLI2; glioma-associated oncogene family zinc finger 2; oncogene GLI2; tax helper protein 1; tax helper protein 2; tax-responsive element-2 holding protein; tax-responsive element-25-bp sequence binding protein; zinc finger protein GLI2 isoform 1; zinc finger protein GLI2",
        "tax_id": 9606,
        "disease": "primary bacterial infectious disease (Disease Ontology:DOID:0050338); spina bifida (Disease Ontology:DOID:0080016); esophageal atresia/tracheoesophageal fistula (Disease Ontology:DOID:0080171); Culler-Jones syndrome (Disease Ontology:DOID:0080328); holoprosencephaly 9 (Disease Ontology:DOID:0110873); biliary atresia (Disease Ontology:DOID:13608)",
        "pathway": " (hsa:2736);  (R-HSA-5610783);  (R-HSA-5610787);  (R-HSA-5632684);  (R-HSA-5635851);  (R-HSA-8941284)",
        "pathway_count": 6,
        "publication_count": 173,
        "publication_id_list": "10.1101/2023.09.13.557529;10075717;10433824;10564661;10806483;10966113;11027307;11375483;11960000;12050670;12068298;12123571;12138125;12192414;12361967;12426310;12435627;14528312;14581620;14603322;14611647;14723851;15087129;15107406;15115751;15198976;15300262;15537544;15930098;15994174;16061793;16136078;16155214;16229832;16254602;16311594;16339192;16396903;16421275;16459297;16459298;16493421;16611981;16651542;16707575;16740475;16980583;17027958;17096318;17115028;17200122;17283082;17442700;17442891;17553904;17641202;17762891;17960137;18327258;18455992;18497258;18669648;18827223;18832070;19000668;19056373;19196978;19223390;19286674;19305393;19365551;19368795;19371734;19533801;19549984;19592253;19622347;19666503;19684112;19767740;19776033;19818708;19852954;19877275;19878745;19906846;19948480;19955409;19996169;20014402;20016067;20067783;20068231;20154143;20207148;20360384;20395968;20412786;20460306;20487519;20512148;20643644;20685856;20818436;20844016;20889716;20956384;2105456;21204792;21209331;21695114;21801010;21878643;22007132;22028470;22231273;22391300;22391301;22982193;23209152;23301498;23332756;23408573;23719536;23725801;23762415;23955340;24072710;24302888;24311597;24339784;24582806;24845016;24854174;24863049;24917297;24925320;24952464;26565916;26992070;27535533;27846572;2850480;28834231;28973407;29351928;29786170;30059200;30420690;30429286;30620550;31217245;31492838;31848261;32157095;32387766;32488085;33592498;34267186;35051231;35254053;35580925;36010968;38385859;38453045;38509065;38665916;38896052;38968120;8350401;9557682;9601642;9874371",
        "class_list": "",
        "function": "(Microbial infection) Acts as a transcriptional activator in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682)., [UniProtKB, PubMed, PubMed]; (Microbial infection) Acts as a transcriptional activators in T-cell leukemia virus type 1 (HTLV-1)-infected cells in a Tax-dependent manner. Binds to the DNA sequence 5'-GAACCACCCA-3' which is part of the Tax-responsive element (TRE-2S) regulatory element that augments the Tax-dependent enhancer of HTLV-1 (PubMed:9557682)., [UniProtKB, PubMed, PubMed]; Acts as a transcriptional repressor., [UniProtKB, PubMed]; GLI family zinc finger protein 2 promotes skin fibroblast proliferation and DNA damage repair by targeting the miR-200/ataxia telangiectasia mutated axis in diabetic wound healing., [RefSeq, PubMed]; Heterozygous missense variant in GLI2 impairs human endocrine pancreas development. Publication Status: Online-Only, [RefSeq, PubMed]; Involved in the smoothened (SHH) signaling pathway., [UniProtKB, PubMed]; KRAS Promotes GLI2-Dependent Transcription during Pancreatic Carcinogenesis., [RefSeq, PubMed]; Positive regulation of Hedgehog signaling via phosphorylation of GLI2/GLI3 by DYRK2 kinase., [RefSeq, PubMed]; TGF-beta1/SMAD3-driven GLI2 isoform expression contributes to aggressive phenotypes of hepatocellular carcinoma., [RefSeq, PubMed]; This gene encodes a protein which belongs to the C2H2-type zinc finger protein subclass of the Gli family. Members of this subclass are characterized as transcription factors which bind DNA through zinc finger motifs. These motifs contain conserved H-C links. Gli family zinc finger proteins are mediators of Sonic hedgehog (Shh) signaling and they are implicated as potent oncogenes in the embryonal carcinoma cell. The protein encoded by this gene localizes to the cytoplasm and activates patched Drosophila homolog (PTCH) gene expression. It is also thought to play a role during embryogenesis. The encoded protein is associated with several phenotypes- Greig cephalopolysyndactyly syndrome, Pallister-Hall syndrome, preaxial polydactyly type IV, postaxial polydactyly types A1 and B. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcription factor that acts as a key effector of the smoothened signaling pathway, and which plays a role in skeleton development (PubMed:15994174, PubMed:18455992, PubMed:19878745, PubMed:20154143, PubMed:20685856, PubMed:24311597, PubMed:26565916, PubMed:9557682). Specifically binds to the minimal GLI-consensus sequence 5'-GACCACCCA-3' to activate or repress the expression of target genes (By similarity). Functions both as a transcriptional activator and repressor: the full-length GLI2 form (Transcription activator GLI2) acts as a transcription activator following smoothened activation, while the Transcription repressor GLI2R, which is generated in absence of smoothened, acts as a transcription repressor (By similarity). The transcriptional activator form constitutes the major form of GLI2 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed]; Transcription factor, which activates expression of target genes in response to smoothened (SMO) activation (PubMed:18455992, PubMed:19878745, PubMed:24311597, PubMed:26565916, PubMed:9557682). Constitutes a major form of GLI2, while the transcription repressor form (GLI2R) plays a minor role (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Transcription repressor, which inhibits expression of target genes in the absence of smoothened (SMO) signaling (By similarity). Generated by proteolytic processing of the full-length GLI2 form in the absence of hedgehog (DHH, IHH or SHH), when SMO transducer is inhibited (By similarity). Constitutes a minor form of GLI2, while the transcription activator GLI2 form plays a major role in smoothened signaling (By similarity)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 5,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 29,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 66,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 6,
        "glyco_site_count": 11,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60252;O60253;O60254;O60255;Q15590;Q15591;Q4JHT4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005813 centrosome;GO:0005829 cytosol",
        "go_biological_process": "GO:0007418 ventral midline development;GO:0007442 hindgut morphogenesis;GO:0009913 epidermal cell differentiation;GO:0021696 cerebellar cortex morphogenesis;GO:0021508 floor plate formation",
        "synthesized_glycan_count": 0,
        "hit_score": 18.2,
        "record_id": "P10070-5",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86Z14-1",
        "uniprot_id": [
            {
                "id": "KLOTB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86Z14",
                "type": "external"
            }
        ],
        "mass": 119808.0,
        "length": 1044,
        "protein_name": "Beta-klotho",
        "gene_name": "KLB",
        "organism": "Human",
        "refseq_name": "beta-klotho",
        "refseq_ac": [
            {
                "id": "NP_783864",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_783864",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KLB",
        "gene_names_refseq": "BKL; KLB",
        "protein_names_uniprotkb": "Beta-klotho; BKL; BetaKlotho; Klotho beta-like protein",
        "protein_names_refseq": "b-Klotho; beta-klotho; betaKlotho; klotho beta like; klotho beta-like protein",
        "tax_id": 9606,
        "disease": "kidney disease (Disease Ontology:DOID:557)",
        "pathway": " (hsa:152831);  (R-HSA-109704);  (R-HSA-1257604);  (R-HSA-1307965);  (R-HSA-2219530);  (R-HSA-5654228);  (R-HSA-5654712);  (R-HSA-5654719);  (R-HSA-5654720);  (R-HSA-5654733);  (R-HSA-5673001);  (R-HSA-6811558)",
        "pathway_count": 12,
        "publication_count": 165,
        "publication_id_list": "10191262;10508167;10579907;10629055;10652257;10869344;11027663;11090077;11136978;11147812;11313946;11353842;11447289;11546808;11702783;11803464;11997436;12032311;12094235;12121613;12167717;12419216;12660731;12767043;12815057;12974390;1325671;1379698;1381348;14506247;14534538;14707138;15094036;15356145;1545823;15546878;15718470;15834429;15863030;16339315;16358222;16456541;1656221;16627759;16647110;16684964;16844695;16847462;1716764;17200115;17227708;17339340;17623664;17626883;17627937;17711860;17998941;18079394;18259951;18317450;18373495;18452557;18594509;18606717;18754654;18755892;18775330;18829467;18829560;18840094;18925875;1898771;19063940;19117008;19185485;19187780;19279408;19411071;19438505;19576174;19644473;19652666;19805105;19920141;19962665;20080590;20231295;20338997;20478380;20522708;20713702;21102635;21188471;21317208;21368164;21372320;21478295;21668414;21779497;21779505;21827948;21976531;21984976;21993244;22120714;22188813;22569528;22588880;22589270;22750304;22802530;23103841;23303910;23443682;23575685;24897931;24937142;25219551;25781681;26085527;27862975;28778966;29741879;29786170;31135801;32983136;33592498;35051231;35251023;37074911;37217939;37582861;37660729;38141848;39048709;39226764;6148751;7543144;7559490;7637810;7744773;7809086;7935463;7972015;8052307;8264585;8394845;8493579;8622701;8645157;8657148;8665852;8710374;8780727;8939933;9045692;9182757;9299490;9480847;9604935;9632781;9660748;9736715;9895304;9927426",
        "class_list": "glycogene;glycosylhydrolase",
        "function": "A functional FGF19 receptor may consist of FGF receptor (FGFR) and heparan sulfate complexed with either alphaKlotho or betaKlotho, [RefSeq, PubMed]; Both FGF23 and FGF21 require intact alpha or betaKlotho for signaling, respectively, whereas FGF19 can signal through a Klotho chimera consisting of the N terminus of alphaKlotho and the C terminus of betaKlotho., [RefSeq, PubMed]; Contributes to the transcriptional repression of cholesterol 7-alpha-hydroxylase (CYP7A1), the rate-limiting enzyme in bile acid synthesis. Probably inactive as a glycosidase. Increases the ability of FGFR1 and FGFR4 to bind FGF21 (By similarity)., [UniProtKB]; Development and validation of a predictive model based on beta-Klotho for head and neck squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; FGF21 prevents neuronal cell ferroptosis after spinal cord injury by activating the FGFR1/beta-Klotho pathway., [RefSeq, PubMed]; High expression of Klotho is associated with ovarian disease progression, [RefSeq, PubMed]; Klotho-beta attenuates Rab8a-mediated exosome regulation and promotes prostate cancer progression., [RefSeq, PubMed]; Liver-secreted FGF21 induces sarcopenia by inhibiting satellite cell myogenesis via klotho beta in decompensated cirrhosis., [RefSeq, PubMed]; Liver-specific activities of FGF19 require Klotho beta., [RefSeq, PubMed]; Lysine tRNA fragments and miR-194-5p co-regulate hepatic steatosis via beta-Klotho and perilipin 2., [RefSeq, PubMed]; The down-regulation of the renal klotho gene could increase renal damage induced by angiotensin II, while klotho gene induction could have therapeutic possibilities in treating angiotensin II-induced kidney damage. Review article, [RefSeq, PubMed]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 7,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1200,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 5,
        "disease_count": 1,
        "glyco_site_count": 12,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2M3K8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004553 hydrolase activity, hydrolyzing O-glycosyl compounds;GO:0017134 fibroblast growth factor binding;GO:0005104 fibroblast growth factor receptor binding",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0005975 carbohydrate metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 17.7,
        "record_id": "Q86Z14-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000010000.101.10100",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H6Q3-1",
        "uniprot_id": [
            {
                "id": "SLAP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H6Q3",
                "type": "external"
            }
        ],
        "mass": 28585.0,
        "length": 261,
        "protein_name": "Src-like-adapter 2",
        "gene_name": "SLA2",
        "organism": "Human",
        "refseq_name": "src-like-adapter 2 isoform a",
        "refseq_ac": [
            {
                "id": "NP_115590",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115590",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLA2; C20orf156; SLAP2",
        "gene_names_refseq": "C20orf156; MARS; SLA2; SLAP-2; SLAP2",
        "protein_names_uniprotkb": "Src-like-adapter 2; MARS; Modulator of antigen receptor signaling; SLAP-2; Src-like adapter protein 2",
        "protein_names_refseq": "Src-like adapter protein-2; modulator of antigen receptor signaling; src-like-adapter 2 isoform a",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:84174);  (R-HSA-9706369)",
        "pathway_count": 2,
        "publication_count": 44,
        "publication_id_list": "11696592;11891219;12024036;12527895;16684964;17110436;17446348;18192505;19276253;20828795;21072051;21262971;22438257;22942183;22952242;23300935;23548639;23707526;24705897;24715725;25505266;25576301;26154972;26308771;27458164;27666490;27846572;27920218;28086240;28611190;28832583;29242379;29632711;29880609;30315122;31066629;31937595;32502341;32983136;33298915;33617900;33936100;34211107;39531497",
        "class_list": "",
        "function": "Adapter protein, which negatively regulates T-cell receptor (TCR) signaling. Inhibits T-cell antigen-receptor induced activation of nuclear factor of activated T-cells. May act by linking signaling proteins such as ZAP70 with CBL, leading to a CBL dependent degradation of signaling proteins., [UniProtKB, PubMed]; In platelets, SLAP-2 may have function as a negative regulator of GPVI-mediated signaling by interacting with c-Cbl., [RefSeq, PubMed]; Negatively regulates T cell receptor signaling, [RefSeq, PubMed]; SLAP2 Adaptor Binding Disrupts c-CBL Autoinhibition to Activate Ubiquitin Ligase Function., [RefSeq, PubMed]; The human SLAP-2 gene is located on chromosome 20q, and the SLAP-2 coding region consists of seven exons, a unique cDNA encoding an alternatively spliced SLAP-2 isoform has been identified, [RefSeq, PubMed]; This gene encodes a member of the SLAP family of adapter proteins. The encoded protein may play an important receptor-proximal role in downregulating T and B cell-mediated responses and inhibits antigen receptor-induced calcium mobilization. This protein interacts with Cas-Br-M (murine) ecotropic retroviral transforming sequence c. Two transcript variants encoding distinct isoforms have been identified for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K648;E1P5U1;E1P5U2;Q5TH27;Q5TH28;Q8WY18;Q96QI4;Q9H135",
        "ec_number_list": [],
        "go_molecular_function": "GO:0035591 signaling adaptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005770 late endosome;GO:0010008 endosome membrane",
        "go_biological_process": "GO:0050849 negative regulation of calcium-mediated signaling;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0042110 T cell activation;GO:0050776 regulation of immune response;GO:0050860 negative regulation of T cell receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "Q9H6Q3-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6IA86-1",
        "uniprot_id": [
            {
                "id": "ELP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6IA86",
                "type": "external"
            }
        ],
        "mass": 92500.0,
        "length": 826,
        "protein_name": "Elongator complex protein 2",
        "gene_name": "ELP2",
        "organism": "Human",
        "refseq_name": "elongator complex protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001229804",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001229804",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ELP2; STATIP1",
        "gene_names_refseq": "ELP2; MRT58; SHINC-2; STATIP1; StIP",
        "protein_names_uniprotkb": "Elongator complex protein 2; ELP2; SHINC-2; STAT3-interacting protein 1; StIP1",
        "protein_names_refseq": "STAT3-interacting protein 1; elongation protein 2 homolog; elongator complex protein 2 isoform 1; elongator complex protein 2; elongator protein 2; signal transducer and activator of transcription 3 interacting protein 1",
        "tax_id": 9606,
        "disease": "autism spectrum disorder (Disease Ontology:DOID:0060041); autosomal recessive intellectual developmental disorder 58 (Disease Ontology:DOID:0081220); intellectual disability (Disease Ontology:DOID:1059)",
        "pathway": " (hsa:55250);  (R-HSA-3214847)",
        "pathway_count": 2,
        "publication_count": 90,
        "publication_id_list": "10.1101/2023.09.13.557529;10786633;10821277;11237011;11714725;11818576;15313887;16387653;18381289;18623064;18991276;19187765;20018852;22069317;22645359;22854966;23301498;23481700;24715725;25417721;25418920;25576301;25645385;25847581;25960406;26024233;26154972;26375851;26758079;26992070;27846572;28904123;29332244;29437277;29493099;29557506;30315122;30410026;30429286;30779550;31154438;31217245;31530632;31844290;31848261;32157095;32161166;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33393008;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33976153;33981976;34087483;34171305;34211107;34357683;34405274;34509645;34653680;34932366;35051231;35318648;35561310;35580925;36010968;36241641;36284347;36787709;37938771;38665916;39894887;9427644;9558366;9880483",
        "class_list": "",
        "function": "Clinical and molecular findings in a Turkish family with an ultra-rare condition, ELP2-related neurodevelopmental disorder., [RefSeq, PubMed]; Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine) (PubMed:29332244). The elongator complex catalyzes the formation of carboxymethyluridine in the wobble base at position 34 in tRNAs (PubMed:29332244)., [UniProtKB, PubMed]; ELP2 compound heterozygous variants associated with cortico-cerebellar atrophy, nodular heterotopia and epilepsy: Phenotype expansion and review of the literature. Review article, [RefSeq, PubMed]; Elp2 and STAT-3 mediate, at least in part, the stimulation of Hsp70 expression by 4PBA., [RefSeq, PubMed]; Elp2 mutations perturb the epitranscriptome and lead to a complex neurodevelopmental phenotype. Publication Status: Online-Only, [RefSeq, PubMed]; Epilepsy or neurodevelopmental disorders are associated with homozygous and pathogenic ELP2 variation in three siblings., [RefSeq, PubMed]; Studied the possible relationship between STATIP1, STAT3 and CML resistance. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8KAI6;B4DTG0;B4DXP0;E7EP23;E9PCX0;Q53GZ0;Q687Y8;Q8N5C2;Q96GV4;Q96PI7;Q9H9N0;Q9NV81",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019901 protein kinase binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0008023 transcription elongation factor complex;GO:0033588 elongator holoenzyme complex",
        "go_biological_process": "GO:0006357 regulation of transcription by RNA polymerase II;GO:0006417 regulation of translation;GO:0006368 transcription elongation by RNA polymerase II;GO:0002098 tRNA wobble uridine modification",
        "synthesized_glycan_count": 0,
        "hit_score": 9.5,
        "record_id": "Q6IA86-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P09104-1",
        "uniprot_id": [
            {
                "id": "ENOG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P09104",
                "type": "external"
            }
        ],
        "mass": 47269.0,
        "length": 434,
        "protein_name": "Gamma-enolase",
        "gene_name": "ENO2",
        "organism": "Human",
        "refseq_name": "gamma-enolase",
        "refseq_ac": [
            {
                "id": "NP_001966",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001966",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ENO2",
        "gene_names_refseq": "ENO2; HEL-S-279; NSE",
        "protein_names_uniprotkb": "Gamma-enolase; 2-phospho-D-glycerate hydro-lyase; 4.2.1.11; Enolase 2; NSE; Neural enolase; Neuron-specific enolase",
        "protein_names_refseq": "2-phospho-D-glycerate hydro-lyase; 2-phospho-D-glycerate hydrolyase; enolase 2 (gamma, neuronal); epididymis secretory protein Li 279; gamma-enolase; neural enolase; neuron specific gamma enolase; neuron-specific enolase; neuronal enriched enolase; neurone-specific enolase",
        "tax_id": 9606,
        "disease": "Bruck syndrome (Disease Ontology:DOID:0060231); Parkinsonism (Disease Ontology:DOID:0080855); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); urinary bladder cancer (Disease Ontology:DOID:11054); migraine without aura (Disease Ontology:DOID:12783); toxic shock syndrome (Disease Ontology:DOID:14115); hypothyroidism (Disease Ontology:DOID:1459); neuroendocrine carcinoma (Disease Ontology:DOID:1800); breast carcinoma (Disease Ontology:DOID:3459); lung adenocarcinoma (Disease Ontology:DOID:3910); brain disease (Disease Ontology:DOID:936)",
        "pathway": " (hsa:2026);  (R-HSA-70171);  (R-HSA-70263)",
        "pathway_count": 3,
        "publication_count": 142,
        "publication_id_list": "10229653;10714828;11237011;11371164;11506403;11780755;11851336;12093795;12437512;12616532;1278465;12965206;12965222;13538944;14718531;14722102;15289101;15592455;15710582;16033098;16062024;16511037;17804405;18337460;183598;18449899;18510355;18613815;1871135;18910716;18910717;18927083;19118303;19615748;20068231;2045099;21949678;22219026;22544926;23168256;23186163;23446454;23506893;23576270;2462567;25648650;26375851;2792767;2793178;28228285;2846554;28467828;28514659;28649982;28832583;28904123;29242379;29314611;29393594;29508533;2960695;29775581;30192525;30315122;30517626;30524438;30573663;30833945;30994045;31217245;3170585;31844290;3208766;32157095;32161166;32347972;32350084;32357974;32387766;32502341;32504736;32938616;33141586;33298915;3355497;33592498;3385803;33912179;33968037;34171305;34405274;34433824;3453121;34782236;35008409;35051231;35251023;3529090;35561310;36010968;36215666;36459650;3653393;37189072;37938771;38250157;38302568;38710213;38923759;4413246;4555506;4827367;5009693;5687724;6434534;6444721;6451249;6696436;6771269;7144574;7150652;7391027;7573034;7717389;7825568;7989588;8117307;8211187;8325892;8447317;8571957;8645161;8786021;9074930;9382095;9428641;9438414;9493266;9585002;9657976;9678974;9758626",
        "class_list": "",
        "function": "Circular RNA circESYT2 serves as a microRNA-665 sponge to promote the progression of hepatocellular carcinoma through ENO2., [RefSeq, PubMed]; Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis (By similarity). Has neurotrophic and neuroprotective properties on a broad spectrum of central nervous system (CNS) neurons. Binds, in a calcium-dependent manner, to cultured neocortical neurons and promotes cell survival (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; HOXC6-mediated transcriptional activation of ENO2 promotes oral squamous cell carcinoma progression through the Warburg effect., [RefSeq, PubMed]; Neuron-specific enolase at admission as a predictor for stroke volume, severity and outcome in ischemic stroke patients: a prognostic biomarker review. Publication Status: Online-Only, [RefSeq, PubMed]; Neuron-specific enolase in hypertension patients with acute ischemic stroke and its value forecasting long-term functional outcomes. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme, a homodimer, is found in mature neurons and cells of neuronal origin. A switch from alpha enolase to gamma enolase occurs in neural tissue during development in rats and primates. [provided by RefSeq, Jul 2008]., [RefSeq]; Tumor-derived Exosomal ENO2 Modulates Polarization of Tumor-associated Macrophages through Reprogramming Glycolysis to Promote Progression of Diffuse Large B-cell Lymphoma. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "prognostic",
        "glycan_count": 1,
        "disease_count": 12,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z2X9;Q96J33",
        "ec_number_list": [
            {
                "id": "4.2.1.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.11",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0019899 enzyme binding;GO:0042802 identical protein binding;GO:0044877 protein-containing complex binding;GO:0004634 phosphopyruvate hydratase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005938 cell cortex;GO:0009986 cell surface",
        "go_biological_process": "GO:0006094 gluconeogenesis;GO:0032355 response to estradiol;GO:0006096 glycolytic process;GO:0061621 canonical glycolysis;GO:0009410 response to xenobiotic stimulus",
        "synthesized_glycan_count": 0,
        "hit_score": 14.5,
        "record_id": "P09104-1",
        "record_type": "protein",
        "filter_code": "0001000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P21802-1",
        "uniprot_id": [
            {
                "id": "FGFR2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P21802",
                "type": "external"
            }
        ],
        "mass": 92025.0,
        "length": 821,
        "protein_name": "Fibroblast growth factor receptor 2",
        "gene_name": "FGFR2",
        "organism": "Human",
        "refseq_name": "fibroblast growth factor receptor 2 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_000132",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000132",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FGFR2; BEK; KGFR; KSAM",
        "gene_names_refseq": "BBDS; BEK; BFR-1; CD332; CEK3; CFD1; ECT1; FGFR2; JWS; K-SAM; KGFR; TK14; TK25",
        "protein_names_uniprotkb": "Fibroblast growth factor receptor 2; 2.7.10.1; FGFR-2; K-sam; KGFR; Keratinocyte growth factor receptor",
        "protein_names_refseq": "BEK fibroblast growth factor receptor; bacteria-expressed kinase; fibroblast growth factor receptor 2 isoform 1 precursor; keratinocyte growth factor receptor; protein tyrosine kinase, receptor like 14",
        "tax_id": 9606,
        "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); lacrimoauriculodentodigital syndrome 1 (Disease Ontology:DOID:0050331); Beare-Stevenson cutis gyrata syndrome (Disease Ontology:DOID:0050660); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); bent bone dysplasia syndrome 1 (Disease Ontology:DOID:0060992); bone disease (Disease Ontology:DOID:0080001); Antley-Bixler syndrome (Disease Ontology:DOID:0081289); Antley-Bixler syndrome without disordered steroidogenesis (Disease Ontology:DOID:0081290); LADD syndrome (Disease Ontology:DOID:0081370); Jackson-Weiss syndrome (Disease Ontology:DOID:0111337); prostate cancer (Disease Ontology:DOID:10283); intestinal atresia (Disease Ontology:DOID:10486); stomach cancer (Disease Ontology:DOID:10534); retinitis pigmentosa (Disease Ontology:DOID:10584); portal hypertension (Disease Ontology:DOID:10762); essential hypertension (Disease Ontology:DOID:10825); hypospadias (Disease Ontology:DOID:10892); urinary bladder cancer (Disease Ontology:DOID:11054); acrocephalosyndactylia (Disease Ontology:DOID:12960); primary pulmonary hypertension (Disease Ontology:DOID:14557); Pfeiffer syndrome (Disease Ontology:DOID:14705); Saethre-Chotzen syndrome (Disease Ontology:DOID:14768); breast cancer (Disease Ontology:DOID:1612); squamous cell carcinoma (Disease Ontology:DOID:1749); transient cerebral ischemia (Disease Ontology:DOID:224); Crouzon syndrome (Disease Ontology:DOID:2339); craniosynostosis (Disease Ontology:DOID:2340); transitional cell carcinoma (Disease Ontology:DOID:2671); endometriosis (Disease Ontology:DOID:289); Epstein-Barr virus infectious disease (Disease Ontology:DOID:2938); high grade glioma (Disease Ontology:DOID:3070); dysgerminoma (Disease Ontology:DOID:4441); stomach carcinoma (Disease Ontology:DOID:5517); hepatocellular carcinoma (Disease Ontology:DOID:684); female breast carcinoma (Disease Ontology:DOID:7843); intestinal volvulus (Disease Ontology:DOID:8445); Kaposi's sarcoma (Disease Ontology:DOID:8632); familial scaphocephaly syndrome, McGillivray type (MONDO:MONDO:0012307)",
        "pathway": " (hsa:2263);  (R-HSA-2023837);  (R-HSA-2033519);  (R-HSA-5655253);  (R-HSA-8851708);  (R-HSA-8853333)",
        "pathway_count": 6,
        "publication_count": 188,
        "publication_id_list": "10.1101/2023.09.13.557529;10067911;10076886;10076887;10196476;10394936;10406670;10490103;10574673;10574949;10579907;10618369;10626794;10633130;10652257;10712195;10830168;10918587;10945669;10951518;11055896;11069186;11121055;11157491;11173845;11237011;11325814;11380921;11390973;11429702;11689702;11739186;11781872;11856867;12000365;12009017;12034712;12124745;12400058;12529371;12591959;12900900;1309608;1313574;1400433;14534538;15190072;15282208;15448205;15523615;15561780;15629145;15863030;15996217;16061565;16091734;16140923;16384934;16440883;1647213;16501574;16597617;16844695;16959974;16969861;1697263;17311277;17344846;17505008;17525745;17552943;17623664;17803937;18056630;18247426;18337450;18373495;18374639;18381441;18552176;18757403;19060208;19103595;19147536;19381019;19387476;19410646;19749790;19809159;19946327;20094046;20101236;20106510;20179196;20709759;21160078;21355848;21367659;21454610;21596750;21666749;21711248;2172978;22387015;22975805;23558953;23564461;2377625;24122810;24275569;24588013;24858661;26362256;26429889;29557506;30237853;30459171;30833945;31146385;31154438;31844290;31848261;32157095;32409632;32488085;32938616;33981976;34185709;34357683;35051231;35154160;35251023;36010968;37074911;38561822;38674107;38802203;7581378;7607643;7647778;7655462;7668257;7719329;7719333;7719344;7719345;7773297;7866434;7874170;7987400;8205545;8434615;8522336;8528214;8644708;8651276;8663044;8673103;8676562;8696350;8755573;8798788;8946174;8956050;8958319;8961926;9002682;9048930;9150725;9152842;9169049;9266968;9385368;9438390;9452027;9475591;9502772;9521581;9539778;9585583;9586546;9605588;9677057;9693549;9700203;9714439;9719378;9857065",
        "class_list": "glycogene",
        "function": "Elucidating the Role of Wildtype and Variant FGFR2 Structural Dynamics in (Dys)Function and Disorder. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic insights into the 'sandwich fusion' subtype of Klippel-Feil syndrome: novel FGFR2 mutations identified by 21 cases of whole-exome sequencing. Publication Status: Online-Only, [RefSeq, PubMed]; Perinatal imaging findings of a fetus with Pfeiffer syndrome and a heterozygous c.1019A>G, p.Tyr340Cys (Y340C) mutation in FGFR2 presenting a cloverleaf skull, craniosynostosis and short limbs on prenatal ultrasound mimicking thanatophoric dysplasia type II., [RefSeq, PubMed]; The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis. Multiple alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Jan 2009]., [RefSeq]; Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 5,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 17,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 3623,
        "reported_interactions": 0,
        "missing_score": 9015,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 38,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DFC2;E7EVR6;E9PCR0;P18443;Q01742;Q12922;Q14300;Q14301;Q14302;Q14303;Q14304;Q14305;Q14672;Q14718;Q14719;Q1KHY5;Q86YI4;Q8IXC7;Q96KL9;Q96KM0;Q96KM1;Q96KM2;Q9NZU2;Q9NZU3;Q9UD01;Q9UD02;Q9UIH3;Q9UIH4;Q9UIH5;Q9UIH6;Q9UIH7;Q9UIH8;Q9UM87;Q9UMC6;Q9UNS7;Q9UQH7;Q9UQH8;Q9UQH9;Q9UQI0",
        "ec_number_list": [
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            },
            {
                "id": "3.1.13.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-",
                "type": "external"
            },
            {
                "id": "2.7.7.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48",
                "type": "external"
            },
            {
                "id": "2.7.7.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
            },
            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005007 fibroblast growth factor receptor activity;GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008201 heparin binding;GO:0042802 identical protein binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005794 Golgi apparatus;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0048755 branching morphogenesis of a nerve;GO:0060523 prostate epithelial cord elongation;GO:0060527 prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0001525 angiogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 20.1,
        "record_id": "P21802-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000010001.101.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P13929-1",
        "uniprot_id": [
            {
                "id": "ENOB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P13929",
                "type": "external"
            }
        ],
        "mass": 46987.0,
        "length": 434,
        "protein_name": "Beta-enolase",
        "gene_name": "ENO3",
        "organism": "Human",
        "refseq_name": "beta-enolase isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001180432",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180432",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ENO3",
        "gene_names_refseq": "ENO3; GSD13; MSE",
        "protein_names_uniprotkb": "Beta-enolase; 2-phospho-D-glycerate hydro-lyase; 4.2.1.11; Enolase 3; MSE; Muscle-specific enolase; Skeletal muscle enolase",
        "protein_names_refseq": "2-phospho-D-glycerate hydrolyase; beta-enolase isoform 2; enolase 3 (beta, muscle); muscle enriched enolase; muscle-specific enolase; skeletal muscle enolase",
        "tax_id": 9606,
        "disease": "glycogen storage disease XIII (Disease Ontology:DOID:0061288); hereditary spastic paraplegia 2 (Disease Ontology:DOID:0110773); intellectual disability (Disease Ontology:DOID:1059); depressive disorder (Disease Ontology:DOID:1596); aortic valve stenosis (Disease Ontology:DOID:1712); epilepsy (Disease Ontology:DOID:1826); Pelizaeus-Merzbacher disease (Disease Ontology:DOID:3210)",
        "pathway": " (hsa:2027);  (R-HSA-70171);  (R-HSA-70263)",
        "pathway_count": 3,
        "publication_count": 117,
        "publication_id_list": "10229653;10714828;11237011;11371164;11506403;11780755;11851336;12093795;12437512;12616532;1278465;12965206;12965222;13538944;14718531;14722102;15188056;15710582;16511037;17804405;18337460;183598;1840492;18449899;18613815;1871135;18910716;18910717;18927083;19118303;21740066;21949678;22219026;22424782;23168256;2336366;23446454;23481700;23506893;24275569;2462567;25576301;25645385;25648650;2587223;25918939;26154972;27862975;2793178;28228285;2846554;28510447;28514659;28834231;29508533;29557506;2960695;30315122;30379171;30397120;30517626;30941482;31697874;3170585;31844290;3208766;32161166;32938616;32983136;33392160;3355497;33592498;33968037;34171305;34357683;34433824;3453121;34782236;35051231;35154160;3529090;35477821;37938771;38665916;4413246;4555506;4827367;5009693;5687724;6434534;6444721;6451249;6696436;6771269;7144574;7150652;7391027;7573034;7717389;7825568;7989588;8117307;8211187;8325892;8447317;8513787;8571957;8645161;8786021;9382095;9428641;9438414;9493266;9585002;9657976;9678974;9758626",
        "class_list": "",
        "function": "ENO3 promotes colorectal cancer progression by enhancing cell glycolysis. Publication Status: Online-Only, [RefSeq, PubMed]; Enolase 3 (ENO3) overexpression under serine/threonine kinase 11 (STK11) loss-of-function mutations implies that ENO3 might be a selective anticancer target in STK11-mutant cancer., [RefSeq, PubMed]; Enolase that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate in glycolysis and the reverse reaction in gluconeogenesis. Appears to have a function in striated muscle development and regeneration., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; TRK1 forms a complex with human enolases and interacts with tRK1 and human pre-lysyl-tRNA synthetase (preKARS2) Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes one of the three enolase isoenzymes found in mammals. This isoenzyme is found in skeletal muscle cells in the adult where it may play a role in muscle development and regeneration. A switch from alpha enolase to beta enolase occurs in muscle tissue during development in rodents. Mutations in this gene have be associated glycogen storage disease. Alternatively spliced transcript variants encoding different isoforms have been described.[provided by RefSeq, Jul 2010]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 7,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DUI6;B4DUM6;D3DTL2;E7ENK8;Q96AE2",
        "ec_number_list": [
            {
                "id": "4.2.1.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.2.1.11",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0004634 phosphopyruvate hydratase activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0016020 membrane;GO:0070062 extracellular exosome",
        "go_biological_process": "GO:0006094 gluconeogenesis;GO:0006096 glycolytic process;GO:0061621 canonical glycolysis;GO:0021762 substantia nigra development",
        "synthesized_glycan_count": 0,
        "hit_score": 12.0,
        "record_id": "P13929-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P54756-1",
        "uniprot_id": [
            {
                "id": "EPHA5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P54756",
                "type": "external"
            }
        ],
        "mass": 114803.0,
        "length": 1037,
        "protein_name": "Ephrin type-A receptor 5",
        "gene_name": "EPHA5",
        "organism": "Human",
        "refseq_name": "ephrin type-A receptor 5 isoform c",
        "refseq_ac": [
            {
                "id": "NP_001268694",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001268694",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPHA5; BSK; EHK1; HEK7; TYRO4",
        "gene_names_refseq": "CEK7; EHK-1; EHK1; EK7; EPHA5; HEK7; TYRO4",
        "protein_names_uniprotkb": "Ephrin type-A receptor 5; 2.7.10.1; Brain-specific kinase; EHK-1; EK7; EPH homology kinase 1; EPH-like kinase 7; hEK7",
        "protein_names_refseq": "EPH homology kinase 1; EPH-like kinase 7; brain-specific kinase; ephrin type-A receptor 5 isoform c; ephrin type-A receptor 5; epididymis secretory sperm binding protein; receptor protein-tyrosine kinase HEK7; tyrosine-protein kinase receptor EHK-1",
        "tax_id": 9606,
        "disease": "adrenal cortical adenoma (Disease Ontology:DOID:0050891); primary pigmented nodular adrenocortical disease 4 (Disease Ontology:DOID:0070549); alcohol use disorder (Disease Ontology:DOID:1574); brain ischemia (Disease Ontology:DOID:2316); fibrolamellar carcinoma (Disease Ontology:DOID:5015); congestive heart failure (Disease Ontology:DOID:6000); amphetamine abuse (Disease Ontology:DOID:670)",
        "pathway": " (hsa:2044);  (R-HSA-2682334);  (R-HSA-3928663);  (R-HSA-3928665)",
        "pathway_count": 4,
        "publication_count": 39,
        "publication_id_list": "10.1101/2023.09.13.557529;10375373;10769020;10848605;11179879;11237011;11448999;11780069;12084815;12495863;12973357;15351694;15848799;15848800;16511561;17322526;17344846;17428795;17928214;18713744;19525919;20068231;20496116;24190977;29557506;31844290;32157095;33592498;34357683;35051231;35251023;35332588;36164608;36241641;36345952;7748564;7898931;9191074;9499402",
        "class_list": "",
        "function": "Association between EPHA5 methylation status in peripheral blood leukocytes and the risk and prognosis of gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of EPHA5 in lung adenocarcinoma is associated with lymph node metastasis and EGFR mutation., [RefSeq, PubMed]; Immunohistochemical evaluation of forkhead box A1 and EphA5 markers in serous ovarian carcinomas, and their impact on the clinical outcome of patients., [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 most probably constitutes the cognate/functional ligand for EPHA5. Functions as an axon guidance molecule during development and may be involved in the development of the retinotectal, entorhino-hippocampal and hippocamposeptal pathways. Together with EFNA5 plays also a role in synaptic plasticity in adult brain through regulation of synaptogenesis. In addition to its function in the nervous system, the interaction of EPHA5 with EFNA5 mediates communication between pancreatic islet cells to regulate glucose-stimulated insulin secretion (By similarity)., [UniProtKB]; This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, Aug 2013]., [RefSeq]",
        "predicted_glycosites": 5,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 208,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 7,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z3F2",
        "ec_number_list": [
            {
                "id": "3.4.24.81",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity;GO:0005004 GPI-linked ephrin receptor activity",
        "go_cellular_component": "GO:0005791 rough endoplasmic reticulum;GO:0005886 plasma membrane;GO:0030424 axon;GO:0030425 dendrite;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0048013 ephrin receptor signaling pathway;GO:0021766 hippocampus development;GO:0061179 negative regulation of insulin secretion involved in cellular response to glucose stimulus;GO:0007413 axonal fasciculation;GO:0048666 neuron development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "P54756-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1000000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9P0K8-1",
        "uniprot_id": [
            {
                "id": "FOXJ2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9P0K8",
                "type": "external"
            }
        ],
        "mass": 62395.0,
        "length": 574,
        "protein_name": "Forkhead box protein J2",
        "gene_name": "FOXJ2",
        "organism": "Human",
        "refseq_name": "forkhead box protein J2",
        "refseq_ac": [
            {
                "id": "NP_060886",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_060886",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FOXJ2; FHX",
        "gene_names_refseq": "FHX; FOXJ2",
        "protein_names_uniprotkb": "Forkhead box protein J2; Fork head homologous X",
        "protein_names_refseq": "FOXJ2 forkhead factor; fork head homologous X; forkhead box protein J2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:55810);  (R-HSA-9764790)",
        "pathway_count": 2,
        "publication_count": 44,
        "publication_id_list": "10777590;10966786;12787665;17525332;18077418;18564921;18669648;19413330;19690332;20068231;23186163;23481700;24275569;24715725;25505266;25576301;26154972;27862975;28832583;29242379;29331515;29393594;29493099;29508533;29557506;29632711;30206221;30429286;30542730;31844290;31848261;31957176;32157095;32502341;33298915;33592498;33725831;33912179;33982790;35051231;35580925;36420658;38253038;40307207",
        "class_list": "",
        "function": "Low FOXJ2 expression is associated with unfavorable postoperative prognosis of patients with epithelial ovarian cancer., [RefSeq, PubMed]; MicroRNA4545p promotes breast cancer progression by inducing epithelialmesenchymal transition via targeting the FoxJ2/Ecadherin axis., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; The data clearly show that ARHGAP9/FOXJ2 inhibit cell migration and invasion during hepatocellular carcinoma development via inducing the transcription of CDH1. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional activator., [UniProtKB, PubMed]; Transcriptional activator. Able to bind to two different type of DNA binding sites. More effective than isoform FOXJ2.S in transcriptional activation (PubMed:10777590, PubMed:10966786). Plays an important role in spermatogenesis, especially in spermatocyte meiosis (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 14,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AVK4;B2RMP3;Q96PS9;Q9NSN5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0043565 sequence-specific DNA binding;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0000785 chromatin",
        "go_biological_process": "GO:0110059 negative regulation of blood vessel endothelial cell differentiation;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0007283 spermatogenesis;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q9P0K8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14974-1",
        "uniprot_id": [
            {
                "id": "IMB1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14974",
                "type": "external"
            }
        ],
        "mass": 97170.0,
        "length": 876,
        "protein_name": "Importin subunit beta-1",
        "gene_name": "KPNB1",
        "organism": "Human",
        "refseq_name": "importin subunit beta-1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001263382",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001263382",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "KPNB1; NTF97",
        "gene_names_refseq": "IMB1; IPO1; IPOB; Impnb; KPNB1; NTF97",
        "protein_names_uniprotkb": "Importin subunit beta-1; Importin-90; Karyopherin subunit beta-1; Nuclear factor p97; PTAC97; Pore targeting complex 97 kDa subunit",
        "protein_names_refseq": "PTAC97; importin 1; importin 90; importin beta-1 subunit; importin subunit beta-1 isoform 2; importin subunit beta-1; karyopherin (importin) beta 1; nuclear factor p97; pore targeting complex 97 kDa subunit",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3837);  (R-HSA-1169408);  (R-HSA-140342);  (R-HSA-1655829);  (R-HSA-168271);  (R-HSA-168276);  (R-HSA-180746);  (R-HSA-2995383);  (R-HSA-6798695);  (R-HSA-68616);  (R-HSA-909733);  (R-HSA-9615933);  (R-HSA-9636249);  (R-HSA-9692916);  (R-HSA-9828806);  (R-HSA-9918432)",
        "pathway_count": 16,
        "publication_count": 348,
        "publication_id_list": "10205180;10209022;10228156;10318789;10353244;10367892;10395669;10397761;10428864;10542297;10644685;10713148;10805775;10846107;10911995;10929717;10982844;11092454;11095724;11112487;11157743;11229403;11231159;11237011;11283257;11337497;11377645;11404376;11585831;11682607;11788588;11891849;12029096;12095920;12504010;12525615;12582176;12748178;12764225;12766484;12842042;12909626;14645851;14769151;15047845;15131269;15149602;15208624;15297880;15312780;15449939;15485925;15550381;15569692;15629770;15702989;15778442;15836774;15910001;16009940;16112642;16122702;16139798;16171404;16171819;16352599;16407192;16408927;16428300;16549788;16699525;16704975;16715065;16762929;16775314;16815975;16872604;16914094;16987978;17035307;17098863;17209048;17235358;17251292;17270291;17289916;1730654;17351669;17376915;17412287;17449569;17596301;17680271;17716973;17761676;17938174;17969444;18035202;18187419;18239742;18283539;18287095;18292551;18305167;18316408;18575461;18583345;18628300;18669648;18691969;18691976;19073728;19125153;19270716;19380580;19386897;19398035;19608861;19620630;1985200;20068230;20068231;20130243;20133869;20147401;2017166;20219937;20305658;20308324;20363976;20385878;20476751;20576617;20643137;20701745;20711181;20818336;20974814;21555516;21795390;22046132;22084111;2211721;22121020;22223895;22253733;22299025;22312431;22398447;22500989;22544926;22701565;22751019;22770216;23061660;23121362;23186163;23187890;23301498;23481700;23483519;23650620;23783831;23795651;24003239;24366607;24417533;24509444;24622840;24699649;24714562;24715725;24854014;25135833;25371710;25502872;25505266;25576301;25602437;25645385;25689043;25764917;25784553;25810538;25892735;25907116;26139588;26154972;26208004;26320399;26378163;26728094;26853435;26992070;27164085;27203180;27383988;27600516;27846572;27875273;27920218;28071726;28148787;28218747;28228285;28228593;28467828;28832583;28834231;28904123;29242379;29294448;29314611;29393594;29437277;29493099;29508533;29557506;29632711;29769354;29786170;29789417;30185776;30315122;30355688;30410026;30429286;30484775;30485383;30779550;31020640;31034780;31154438;31217245;31231549;31530632;31844290;31848261;31875875;31937595;31998317;32032529;32113509;32119511;32157095;32350084;32357974;32387766;32488085;32502341;32511913;32574262;32661006;32728199;32758689;32808929;32862111;32938616;32983136;33060197;33117408;33123756;33141586;33189161;33193462;33214551;33298899;33298915;33392160;33396578;33592498;33717175;33801762;33912179;33936100;33968037;33981976;34019948;34087483;34171305;34357683;34509645;34561969;34725712;34932366;35051231;35083852;35138101;35154160;35215835;35251023;35318648;35580925;36010968;36241641;36284347;37166548;37217939;37473981;38132118;38254206;38665916;38793607;39302247;40914422;6162102;6548414;688397;7510216;7526154;7537377;7540766;7559393;7615630;7627554;8156598;8197134;8232552;8313914;8605876;8617227;8621447;8674110;8692836;8692944;8702790;9019411;9092824;9096384;9108473;9121453;9242679;9334213;9405152;9488713;9497385;9525617;9634703;9651582;9659902;9660177;9670026;9687515;9847332;9861020;9891055;9891056;9989503",
        "class_list": "",
        "function": "(Microbial infection) In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev., [UniProtKB, PubMed, PubMed, PubMed]; Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Acting autonomously, serves itself as NLS receptor (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649, PubMed:7615630, PubMed:9687515). The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus (PubMed:10228156, PubMed:11682607, PubMed:11891849, PubMed:19386897, PubMed:24699649, PubMed:7615630, PubMed:9687515). Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5 (PubMed:11682607, PubMed:9687515). In association with IPO7, mediates the nuclear import of H1 histone (PubMed:10228156). In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones (By similarity). Imports MRTFA, SNAI1 and PRKCI into the nucleus (PubMed:11891849, PubMed:19386897, PubMed:20818336, PubMed:24699649)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Human RTEL1 Interacts with KPNB1 (Importin beta) and NUP153 and Connects Nuclear Import to Nuclear Envelope Stability in S-Phase. Publication Status: Online-Only, [RefSeq, PubMed]; KPNB1-mediated nuclear import in cancer. Review article, [RefSeq, PubMed]; MicroRNA-130a-3p impedes the progression of papillary thyroid carcinoma through downregulation of KPNB1 by targeting PSME3., [RefSeq, PubMed]; Nucleocytoplasmic transport, a signal- and energy-dependent process, takes place through nuclear pore complexes embedded in the nuclear envelope. The import of proteins containing a nuclear localization signal (NLS) requires the NLS import receptor, a heterodimer of importin alpha and beta subunits also known as karyopherins. Importin alpha binds the NLS-containing cargo in the cytoplasm and importin beta docks the complex at the cytoplasmic side of the nuclear pore complex. In the presence of nucleoside triphosphates and the small GTP binding protein Ran, the complex moves into the nuclear pore complex and the importin subunits dissociate. Importin alpha enters the nucleoplasm with its passenger protein and importin beta remains at the pore. Interactions between importin beta and the FG repeats of nucleoporins are essential in translocation through the pore complex. The protein encoded by this gene is a member of the importin beta family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2013]., [RefSeq]; Stabilization of KPNB1 by deubiquitinase USP7 promotes glioblastoma progression through the YBX1-NLGN3 axis. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 9,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZAV6;D3DTT3;Q14637;Q53XN2;Q96J27",
        "ec_number_list": [],
        "go_molecular_function": "GO:0061676 importin-alpha family protein binding;GO:0003723 RNA binding;GO:0008270 zinc ion binding;GO:0019899 enzyme binding;GO:0019904 protein domain specific binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005635 nuclear envelope;GO:0005643 nuclear pore;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0007079 mitotic chromosome movement towards spindle pole;GO:0006610 ribosomal protein import into nucleus;GO:0090307 mitotic spindle assembly;GO:0045540 regulation of cholesterol biosynthetic process;GO:0045542 positive regulation of cholesterol biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 35.2,
        "record_id": "Q14974-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16659-1",
        "uniprot_id": [
            {
                "id": "MK06_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16659",
                "type": "external"
            }
        ],
        "mass": 82681.0,
        "length": 721,
        "protein_name": "Mitogen-activated protein kinase 6",
        "gene_name": "MAPK6",
        "organism": "Human",
        "refseq_name": "mitogen-activated protein kinase 6",
        "refseq_ac": [
            {
                "id": "NP_002739",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002739",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MAPK6; ERK3; PRKM6",
        "gene_names_refseq": "ERK3; HsT17250; MAPK6; PRKM6; p97MAPK",
        "protein_names_uniprotkb": "Mitogen-activated protein kinase 6; 2.7.11.24; ERK-3; Extracellular signal-regulated kinase 3; MAP kinase 6; MAP kinase isoform p97; MAPK 6; p97-MAPK",
        "protein_names_refseq": "ERK-3; MAP kinase 6; MAPK 6; extracellular signal-regulated kinase 3; extracellular signal-regulated kinase, p97; mitogen-activated protein kinase 6; p97-MAPK; protein kinase, mitogen-activated 5; protein kinase, mitogen-activated 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5597);  (R-HSA-5687128)",
        "pathway_count": 2,
        "publication_count": 142,
        "publication_id_list": "10470034;10975528;11584266;11741894;11804587;12546821;12808096;12915405;15226418;15538386;15577943;16360641;16371649;16971392;16973613;17161475;17254968;17344846;17395884;17728103;17947239;18031682;18162290;18235225;18248330;18593949;18644862;18669648;18720373;19054851;19166925;19369195;19473979;19513348;19593530;19651622;19664994;20236090;20536836;20543837;20734105;20849292;21177870;21317288;21329875;21329882;21372320;22267219;22279049;22505454;22508986;22645313;22645359;22800433;23069990;23186163;23481700;23878308;24309468;24366607;24585635;24714562;25339975;25576301;25880248;25892735;26154972;26375851;26728094;26992070;27600516;27846572;28218747;28228285;28832583;28834231;28904123;29242379;29371260;29393594;29437277;29493099;29508533;29557506;29632046;30315122;30410026;30429286;30524438;30779550;30833945;31217245;31222486;31530632;31844290;32157095;32314963;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33070159;33141586;33298915;33392160;33537174;33592498;33633747;33691108;33717175;33912179;33968037;33981976;34087483;34171305;34185709;34405274;34509645;34561969;34932366;35051231;35580925;36010968;36250437;36284347;37057894;37215982;37938771;38964515;39894887;7559638;7799959;7969157;8107774;8621539;8875998;9535855;9628874;9747882",
        "class_list": "",
        "function": "Atypical MAPK protein. Phosphorylates microtubule-associated protein 2 (MAP2) and MAPKAPK5. The precise role of the complex formed with MAPKAPK5 is still unclear, but the complex follows a complex set of phosphorylation events: upon interaction with atypical MAPKAPK5, ERK3/MAPK6 is phosphorylated at Ser-189 and then mediates phosphorylation and activation of MAPKAPK5, which in turn phosphorylates ERK3/MAPK6. May promote entry in the cell cycle (By similarity)., [UniProtKB]; ERK3/MAPK6 dictates CDC42/RAC1 activity and ARP2/3-dependent actin polymerization. Publication Status: Online-Only, [RefSeq, PubMed]; Increased methylation of ZNF671 suppresses tumor progression by promoting MAPK6 transcription in laryngeal carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-128-3p inhibits the inflammation by targeting MAPK6 in penicillin-induced astrocytes., [RefSeq, PubMed]; The circ_0003928/miR-31-5p/MAPK6 cascade affects high glucose-induced inflammatory response, fibrosis and oxidative stress in HK-2 cells., [RefSeq, PubMed]; The protein encoded by this gene is a member of the Ser/Thr protein kinase family, and is most closely related to mitogen-activated protein kinases (MAP kinases). MAP kinases also known as extracellular signal-regulated kinases (ERKs), are activated through protein phosphorylation cascades and act as integration points for multiple biochemical signals. This kinase is localized in the nucleus, and has been reported to be activated in fibroblasts upon treatment with serum or phorbol esters. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 18,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R945;B5BU65;Q68DH4;Q8IYN8",
        "ec_number_list": [
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.21",
                "type": "external"
            },
            {
                "id": "3.4.19.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.19.12",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.-",
                "type": "external"
            },
            {
                "id": "2.7.11.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.4",
                "type": "external"
            },
            {
                "id": "2.7.11.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.10",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.25",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
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            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
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            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
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            {
                "id": "2.7.11.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.39",
                "type": "external"
            },
            {
                "id": "3.1.26.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.26.-",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.2.3",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.11.-",
                "type": "external"
            },
            {
                "id": "2.7.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.6",
                "type": "external"
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            {
                "id": "2.7.13.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.13.3",
                "type": "external"
            },
            {
                "id": "2.7.4.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.4.18",
                "type": "external"
            },
            {
                "id": "3.1.24.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.24.-",
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            },
            {
                "id": "2.7.11.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.11",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "3.4.25.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.25.1",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
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            {
                "id": "2.7.1.153",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.153",
                "type": "external"
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            {
                "id": "2.7.1.137",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.137",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.1.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.154",
                "type": "external"
            },
            {
                "id": "2.7.11.31",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.31",
                "type": "external"
            },
            {
                "id": "2.3.2.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.27",
                "type": "external"
            },
            {
                "id": "2.7.11.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.12",
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            {
                "id": "2.7.11.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.17",
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            {
                "id": "2.7.11.8",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.8",
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            {
                "id": "2.7.11.19",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.19",
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            },
            {
                "id": "4.1.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.32",
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            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
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            {
                "id": "2.7.11.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.38",
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                "id": "2.7.11.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.34",
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            {
                "id": "3.6.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.-.-",
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            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
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            {
                "id": "2.7.1.150",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.150",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004674 protein serine/threonine kinase activity;GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0004707 MAP kinase activity",
        "go_cellular_component": "GO:0032156 septin cytoskeleton;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006468 protein phosphorylation;GO:0007165 signal transduction;GO:0035556 intracellular signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 14.5,
        "record_id": "Q16659-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95602-1",
        "uniprot_id": [
            {
                "id": "RPA1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95602",
                "type": "external"
            }
        ],
        "mass": 194811.0,
        "length": 1720,
        "protein_name": "DNA-directed RNA polymerase I subunit RPA1",
        "gene_name": "POLR1A",
        "organism": "Human",
        "refseq_name": "DNA-directed RNA polymerase I subunit RPA1",
        "refseq_ac": [
            {
                "id": "NP_056240",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056240",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "POLR1A",
        "gene_names_refseq": "A190; AFDCIN; HLD27; POLR1A; RPA190; RPA194; RPA1; RPO1-4; RPO14",
        "protein_names_uniprotkb": "DNA-directed RNA polymerase I subunit RPA1; 2.7.7.6; A190; DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A; RNA polymerase I 194 kDa subunit; RNA polymerase I subunit A1; RPA194",
        "protein_names_refseq": "DNA-directed RNA polymerase I largest subunit; DNA-directed RNA polymerase I subunit A1; DNA-directed RNA polymerase I subunit RPA1; RNA polymerase I 194 kDa subunit; polymerase (RNA) I polypeptide A, 194kDa; polymerase (RNA) I subunit A",
        "tax_id": 9606,
        "disease": "acrofacial dysostosis Cincinnati type (Disease Ontology:DOID:0060353); hypomyelinating leukodystrophy (Disease Ontology:DOID:0060786); leukodystrophy, hypomyelinating, 27 (MONDO:MONDO:0958018)",
        "pathway": " (hsa:25885);  (R-HSA-427413);  (R-HSA-5250924);  (R-HSA-73762);  (R-HSA-73772);  (R-HSA-73863)",
        "pathway_count": 6,
        "publication_count": 126,
        "publication_id_list": "10082553;10471499;10913176;11237011;11250901;11250903;11283244;12393749;12446911;12646563;14610093;14969726;1547496;15558034;16514417;16603771;16809778;16858408;17318177;17355984;18452278;18669648;18991276;19691289;19838300;20068231;21555369;21559432;21872626;22544926;22645359;22805593;23186163;23555303;23667505;24366607;24714562;24715725;24901984;24952918;25505266;25576301;25880248;25913037;25916849;26089203;26154972;26992070;27418187;27418309;27502483;27600516;27846572;27920218;2805069;28051070;28218747;28228285;28514659;28832583;28834231;28904123;29242379;29371260;29393594;29437277;29493099;29508533;29557506;29632046;29632711;29769354;29786170;29789417;30315122;30410026;30429286;30484775;30524438;31217245;31844290;32157095;32357974;32387766;32502341;32897882;32938616;32983136;33141586;33298915;33392160;33592498;33633747;33717175;33912179;33936100;33968037;33981976;34087483;34171305;34185709;34211107;34405274;34509645;34561969;34671025;34887565;34932366;35051231;35154160;35251023;35318648;35580925;36010968;36215666;36241641;36271492;36284347;36917474;37075751;37167337;37938771;7491500;7597036;7801123;9582279",
        "class_list": "",
        "function": "Analyzed the kinetics of assembly and elongation of the RNA polymerase I complex on endogenous ribosomal genes in the nuclei of living cells with the use of in vivo microscopy [RPA43], [RefSeq, PubMed]; Catalytic core component of RNA polymerase I (Pol I), a DNA-dependent RNA polymerase which synthesizes ribosomal RNA precursors using the four ribonucleoside triphosphates as substrates. Transcribes 47S pre-rRNAs from multicopy rRNA gene clusters, giving rise to 5.8S, 18S and 28S ribosomal RNAs (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Pol I-mediated transcription cycle proceeds through transcription initiation, transcription elongation and transcription termination stages. During transcription initiation, Pol I pre-initiation complex (PIC) is recruited by the selectivity factor 1 (SL1/TIF-IB) complex bound to the core promoter that precedes an rDNA repeat unit. The PIC assembly bends the promoter favoring the formation of the transcription bubble and promoter escape. Once the polymerase has escaped from the promoter it enters the elongation phase during which RNA is actively polymerized, based on complementarity with the template DNA strand. Highly processive, assembles in structures referred to as 'Miller trees' where many elongating Pol I complexes queue and transcribe the same rDNA coding regions. At terminator sequences downstream of the rDNA gene, PTRF interacts with Pol I and halts Pol I transcription leading to the release of the RNA transcript and polymerase from the DNA (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492). Forms Pol I active center together with the second largest subunit POLR1B/RPA2. Appends one nucleotide at a time to the 3' end of the nascent RNA, with POLR1A/RPA1 contributing a Mg(2+)-coordinating DxDGD motif, and POLR1B/RPA2 participating in the coordination of a second Mg(2+) ion and providing lysine residues believed to facilitate Watson-Crick base pairing between the incoming nucleotide and the template base. Typically, Mg(2+) ions direct a 5' nucleoside triphosphate to form a phosphodiester bond with the 3' hydroxyl of the preceding nucleotide of the nascent RNA, with the elimination of pyrophosphate. Has proofreading activity: Pauses and backtracks to allow the cleavage of a missincorporated nucleotide via POLR1H/RPA12. High Pol I processivity is associated with decreased transcription fidelity (By similarity) (PubMed:11250903, PubMed:11283244, PubMed:16858408, PubMed:34671025, PubMed:34887565, PubMed:36271492)., [UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates., [UniProtKB, UniProtKB]; Expression of RNA polymerase I catalytic core is influenced by RPA12. Publication Status: Online-Only, [RefSeq, PubMed]; POLR1A variants underlie phenotypic heterogeneity in craniofacial, neural, and cardiac anomalies., [RefSeq, PubMed]; The protein encoded by this gene is the largest subunit of the RNA polymerase I complex. The encoded protein represents the catalytic subunit of the complex, which transcribes DNA into ribosomal RNA precursors. Defects in this gene are a cause of the Cincinnati type of acrofacial dysostosis. [provided by RefSeq, May 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 50,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z7T0;D6W5M0;Q0VG05;Q9UEH0;Q9UFT9",
        "ec_number_list": [
            {
                "id": "2.7.7.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "5.6.2.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.3",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.1.13.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-",
                "type": "external"
            },
            {
                "id": "2.7.7.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.11.26",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.26",
                "type": "external"
            },
            {
                "id": "2.7.11.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.24",
                "type": "external"
            },
            {
                "id": "2.7.11.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.22",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "2.3.1.57",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.57",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0000287 magnesium ion binding;GO:0003677 DNA binding;GO:0003682 chromatin binding;GO:0008270 zinc ion binding;GO:0003899 DNA-directed RNA polymerase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0001650 fibrillar center;GO:0000785 chromatin;GO:0005694 chromosome",
        "go_biological_process": "GO:0006360 transcription by RNA polymerase I;GO:1904750 negative regulation of protein localization to nucleolus;GO:0006362 transcription elongation by RNA polymerase I;GO:0006361 transcription initiation at RNA polymerase I promoter;GO:0006363 termination of RNA polymerase I transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 12.7,
        "record_id": "O95602-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13127-1",
        "uniprot_id": [
            {
                "id": "REST_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13127",
                "type": "external"
            }
        ],
        "mass": 121872.0,
        "length": 1097,
        "protein_name": "RE1-silencing transcription factor",
        "gene_name": "REST",
        "organism": "Human",
        "refseq_name": "RE1-silencing transcription factor isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001180437",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001180437",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "REST; NRSF; XBR",
        "gene_names_refseq": "DFNA27; GINGF5; HGF5; NRSF; REST; WT6; XBR",
        "protein_names_uniprotkb": "RE1-silencing transcription factor; Neural-restrictive silencer factor; X2 box repressor",
        "protein_names_refseq": "RE1-silencing transcription factor isoform 1; neural-restrictive silencer factor; neuron restrictive silencer factor; repressor binding to the X2 box",
        "tax_id": 9606,
        "disease": "gingival fibromatosis 5 (Disease Ontology:DOID:0080280); autosomal dominant nonsyndromic deafness 27 (Disease Ontology:DOID:0110556); alcohol use disorder (Disease Ontology:DOID:1574); nephroblastoma (Disease Ontology:DOID:2154); Wilms tumor 6 (MONDO:MONDO:0014779)",
        "pathway": " (hsa:5978);  (R-HSA-3214815);  (R-HSA-8943724);  (R-HSA-9031628);  (R-HSA-9679191);  (R-HSA-9768777)",
        "pathway_count": 6,
        "publication_count": 265,
        "publication_id_list": "10078534;10087012;10203854;10381005;10444591;10449787;10521596;10611221;10611312;10656257;10734093;10734128;10748112;10826704;10872467;10882540;10904264;10922406;10926844;10984481;11018254;11027551;11237011;11280768;11331872;11343657;11378386;11509652;11545734;11567222;11739383;11741002;11742974;11755530;11779185;11781575;11840323;11909966;11956230;11959846;12032298;12399542;12511643;12724404;1377233;14522948;14597720;14645515;14969744;15102911;15161978;15449318;15542842;15620361;1570299;15733869;15836632;15880109;16034366;16115318;16136673;16187211;16221685;16260776;16287845;16288918;16339507;16407550;16418168;16442230;16484497;16522641;16574654;16676006;16702404;16732277;16823502;17088210;17088211;17088212;17211407;17632064;17662961;17873065;17898216;17974977;18056528;18088355;18160048;18172008;1833716;18354482;18391013;18456662;18487508;18524893;1861162;19061646;19116276;19193899;19194657;19440552;19884659;19926875;20068231;2017159;20223979;20233713;2040600;20506119;20516213;2052361;2072895;21057636;2109185;21258371;21284946;21289308;21326363;21486943;21587264;21621608;22053691;22065583;22128185;22302795;2237820;22401777;22552008;22814904;23186163;23287862;23481700;23641311;24060757;24272870;24291638;24584101;24670762;24715725;24718924;25248477;25569790;25576301;25728608;25748042;25801024;26002965;26018600;26053433;26101246;26154972;26375851;26551668;2676516;26910647;26992070;27041596;27128622;27220739;27531581;27600516;27920218;28076410;28275114;28286024;28425720;28686854;28832583;28834231;28904123;29242379;29493099;29557506;29559111;29632711;29786170;29945920;29961578;30201761;30315122;30410026;30429286;30484775;30524438;30684677;30833945;31048504;3127059;31530632;31844290;31848261;32157095;32357974;32387766;32488085;32502341;32522876;32897882;32938616;32983136;33298915;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34509645;34561969;34932366;35051231;35580925;36010968;36215666;36241641;36284347;3672127;37217939;38866867;38940038;39080761;39273639;39430242;7513682;7551568;7592934;7595538;7608156;7624335;7697725;7777577;7823924;7857651;7871435;7876254;7923378;8090221;8090222;8248782;8413279;8483478;8568247;8576248;8583621;8668170;8756618;8846918;8918830;9032251;9084409;9150135;9343422;9390517;9418898;9622090;9651585;9722618;9770464;9774344;9790534;9808461;9822744;9858769",
        "class_list": "",
        "function": "Binds to the 3' region of the neuron-restrictive silencer element (NRSE), with lower affinity than full-length REST isoform 1 (By similarity). Exhibits weaker repressor activity compared to isoform 1 (PubMed:11779185). May negatively regulate the repressor activity of isoform 1 by binding to isoform 1, thereby preventing its binding to NRSE and leading to derepression of target genes (PubMed:11779185). However, in another study, does not appear to be implicated in repressor activity of a NRSE motif-containing reporter construct nor in inhibitory activity on the isoform 1 transcriptional repressor activity (PubMed:11741002). Post-transcriptional inactivation of REST by SRRM4-dependent alternative splicing into isoform 3 is required in mechanosensory hair cells in the inner ear for derepression of neuronal genes and hearing (By similarity)., [UniProtKB, UniProtKB, PubMed, PubMed]; Functional Analysis of RE1 Silencing Transcription Factor as a Putative Tumor Suppressor in Human Endometrial Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; KIF15 promotes human glioblastoma progression under the synergistic transactivation of REST and P300. Publication Status: Online-Only, [RefSeq, PubMed]; REST Promotes Autophagy in Gastric Cancer by Transcriptionally Activating FABP6 to Inhibit the Akt/mTOR Signaling Pathway., [RefSeq, PubMed]; REST-dependent downregulation of von Hippel-Lindau tumor suppressor promotes autophagy in SHH-medulloblastoma. Publication Status: Online-Only, [RefSeq, PubMed]; SMARCA4 controls state plasticity in small cell lung cancer through regulation of neuroendocrine transcription factors and REST splicing. Erratum:[J Hematol Oncol. 2024 Sep 29;17(1):89. doi: 10.1186/s13045-024-01609-7. PMID: 39343962] Publication Status: Online-Only, [RefSeq, PubMed]; This gene was initially identified as a transcriptional repressor that represses neuronal genes in non-neuronal tissues. However, depending on the cellular context, this gene can act as either an oncogene or a tumor suppressor. The encoded protein is a member of the Kruppel-type zinc finger transcription factor family. It represses transcription by binding a DNA sequence element called the neuron-restrictive silencer element. The protein is also found in undifferentiated neuronal progenitor cells and it is thought that this repressor may act as a master negative regulator of neurogenesis. Alternatively spliced transcript variants have been described. [provided by RefSeq, May 2018]., [RefSeq]; Transcriptional repressor which binds neuron-restrictive silencer element (NRSE) and represses neuronal gene transcription in non-neuronal cells (PubMed:11741002, PubMed:11779185, PubMed:12399542, PubMed:26551668, PubMed:7697725, PubMed:7871435, PubMed:8568247). Restricts the expression of neuronal genes by associating with two distinct corepressors, SIN3A and RCOR1, which in turn recruit histone deacetylase to the promoters of REST-regulated genes (PubMed:10449787, PubMed:10734093). Mediates repression by recruiting the BHC complex at RE1/NRSE sites which acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier (By similarity). Transcriptional repression by REST-CDYL via the recruitment of histone methyltransferase EHMT2 may be important in transformation suppression (PubMed:19061646). Represses the expression of SRRM4 in non-neural cells to prevent the activation of neural-specific splicing events and to prevent production of REST isoform 3 (By similarity). Repressor activity may be inhibited by forming heterodimers with isoform 3, thereby preventing binding to NRSE or binding to corepressors and leading to derepression of target genes (PubMed:11779185). Also maintains repression of neuronal genes in neural stem cells, and allows transcription and differentiation into neurons by dissociation from RE1/NRSE sites of target genes (By similarity). Thereby is involved in maintaining the quiescent state of adult neural stem cells and preventing premature differentiation into mature neurons (PubMed:21258371). Plays a role in the developmental switch in synaptic NMDA receptor composition during postnatal development, by repressing GRIN2B expression and thereby altering NMDA receptor properties from containing primarily GRIN2B to primarily GRIN2A subunits (By similarity). Acts as a regulator of osteoblast differentiation (By similarity). Key repressor of gene expression in hypoxia; represses genes in hypoxia by direct binding to an RE1/NRSE site on their promoter regions (PubMed:27531581). May also function in stress resistance in the brain during aging; possibly by regulating expression of genes involved in cell death and in the stress response (PubMed:24670762). Repressor of gene expression in the hippocampus after ischemia by directly binding to RE1/NRSE sites and recruiting SIN3A and RCOR1 to promoters of target genes, thereby promoting changes in chromatin modifications and ischemia-induced cell death (By similarity). After ischemia, might play a role in repression of miR-132 expression in hippocampal neurons, thereby leading to neuronal cell death (By similarity). Negatively regulates the expression of SRRM3 in breast cancer cell lines (PubMed:26053433)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 13,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2RUE0;B9EGJ0;Q12956;Q12957;Q13134;Q59ER1;Q8IWI3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0042802 identical protein binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0017053 transcription repressor complex",
        "go_biological_process": "GO:1902459 positive regulation of stem cell population maintenance;GO:0060379 cardiac muscle cell myoblast differentiation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0002931 response to ischemia;GO:0006338 chromatin remodeling",
        "synthesized_glycan_count": 0,
        "hit_score": 26.8,
        "record_id": "Q13127-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q13045-1",
        "uniprot_id": [
            {
                "id": "FLII_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q13045",
                "type": "external"
            }
        ],
        "mass": 144751.0,
        "length": 1269,
        "protein_name": "Protein flightless-1 homolog",
        "gene_name": "FLII",
        "organism": "Human",
        "refseq_name": "protein flightless-1 homolog isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001243193",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243193",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FLII; FLIL",
        "gene_names_refseq": "CMD2J; FLII; FLIL; FLI; Fli1",
        "protein_names_uniprotkb": "Protein flightless-1 homolog",
        "protein_names_refseq": "flightless I actin binding protein; flightless I homolog; protein flightless-1 homolog isoform 2; protein flightless-1 homolog",
        "tax_id": 9606,
        "disease": "dilated cardiomyopathy (Disease Ontology:DOID:12930); obesity (Disease Ontology:DOID:9970); cardiomyopathy, dilated, 2j (MONDO:MONDO:0957984)",
        "pathway": " (hsa:2314)",
        "pathway_count": 1,
        "publication_count": 130,
        "publication_id_list": "10366446;11237011;11782012;12665801;14966289;16964243;17081983;17322306;18452278;18669648;18691976;18767875;19265123;19293151;19413330;19415658;19608861;19651622;19664994;19664995;19690332;20058876;20068231;21136679;21406692;22223895;22544926;23186163;23481700;23555621;24275569;24714562;24715725;25576301;25645385;25810538;26154972;26375851;26758079;26768311;26992070;27397612;27452731;27543614;27600516;27846572;27862975;28218747;28228285;28514659;28649982;28832583;28834231;28904123;29242379;29371260;29393594;29437277;29493099;29508533;29557506;29632711;29769354;29786170;29789417;30315122;30429286;30484775;30524438;30779550;30833945;31154438;31217245;31222486;31530632;31844290;31848261;31937595;31998317;32157095;32161166;32350084;32357974;32387766;32488085;32502341;32870709;32897882;32938616;32983136;33141586;33298915;33392160;33537174;33592498;33691108;33717175;33968037;33981976;34011528;34019948;34087483;34171305;34185709;34211107;34405274;34509645;34698116;34725712;34932366;34948000;35051231;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37126682;37217939;37561591;37938771;38665916;40914422;8248259;9177775;9525888;9671805",
        "class_list": "",
        "function": "A human FLII gene variant alters sarcomeric actin thin filament length and predisposes to cardiomyopathy., [RefSeq, PubMed]; FLII and MLL1 Cooperatively Regulate Aryl Hydrocarbon Receptor-Mediated Transcription in ARPE-19 Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Flightless I Homolog Reverses Enzalutamide Resistance through PD-L1-Mediated Immune Evasion in Prostate Cancer., [RefSeq, PubMed]; Increased Expression of Flightless I in Cutaneous Squamous Cell Carcinoma Affects Wnt/beta-Catenin Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Is a regulator of actin polymerization, required for proper myofibril organization and regulation of the length of sarcomeric thin filaments (By similarity). It also plays a role in the assembly of cardiomyocyte cell adhesion complexes (By similarity). Regulates cytoskeletal rearrangements involved in cytokinesis and cell migration, by inhibiting Rac1-dependent paxillin phosphorylation (By similarity). May play a role as coactivator in transcriptional activation by hormone-activated nuclear receptors (NR) and acts in cooperation with NCOA2 and CARM1 (PubMed:14966289). Involved in estrogen hormone signaling., [UniProtKB, PubMed, UniProtKB]; This gene encodes a protein with a gelsolin-like actin binding domain and an N-terminal leucine-rich repeat-protein protein interaction domain. The protein is similar to a Drosophila protein involved in early embryogenesis and the structural organization of indirect flight muscle. The gene is located within the Smith-Magenis syndrome region on chromosome 17. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 9,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DIL0;F5H407;J3QLG3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0005546 phosphatidylinositol-4,5-bisphosphate binding;GO:0051015 actin filament binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005813 centrosome;GO:0005903 brush border;GO:0005925 focal adhesion;GO:0015629 actin cytoskeleton",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0051016 barbed-end actin filament capping;GO:0008154 actin polymerization or depolymerization;GO:0045214 sarcomere organization;GO:0051014 actin filament severing",
        "synthesized_glycan_count": 0,
        "hit_score": 13.3,
        "record_id": "Q13045-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P54762-1",
        "uniprot_id": [
            {
                "id": "EPHB1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P54762",
                "type": "external"
            }
        ],
        "mass": 109885.0,
        "length": 984,
        "protein_name": "Ephrin type-B receptor 1",
        "gene_name": "EPHB1",
        "organism": "Human",
        "refseq_name": "ephrin type-B receptor 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_004432",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004432",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPHB1; ELK; EPHT2; HEK6; NET",
        "gene_names_refseq": "ELK; EPHB1; EPHT2; Hek6; NET",
        "protein_names_uniprotkb": "Ephrin type-B receptor 1; 2.7.10.1; EK6; ELK; EPH tyrosine kinase 2; EPH-like kinase 6; NET; Neuronally-expressed EPH-related tyrosine kinase; Tyrosine-protein kinase receptor EPH-2; hEK6",
        "protein_names_refseq": "EK6; EPH-like kinase 6; eph tyrosine kinase 2; ephrin type-B receptor 1 precursor; ephrin type-B receptor 1; neuronally-expressed EPH-related tyrosine kinase; tyrosine-protein kinase receptor EPH-2",
        "tax_id": 9606,
        "disease": "aortic dissection (Disease Ontology:DOID:0080685); prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); myocardial infarction (Disease Ontology:DOID:5844)",
        "pathway": " (hsa:2047);  (R-HSA-2682334);  (R-HSA-3928662);  (R-HSA-3928664);  (R-HSA-3928665)",
        "pathway_count": 5,
        "publication_count": 101,
        "publication_id_list": "10.1101/2023.09.13.557529;10047984;10219243;10669731;10848605;10995436;11058585;11134074;11237011;11448999;11557983;11580899;11713248;11747816;11780069;11804587;11983165;12084815;12223469;12495863;12546821;12676796;12695502;12702722;12925710;12973357;14988728;15340161;15351694;15378065;15548136;15721239;15800193;15848800;15951569;16298995;16511561;17016520;17310244;17322526;17344846;17389395;17428795;17440041;17548511;17928214;18034775;18593464;18713744;19525919;19553453;19615748;19915143;20496116;2201922;23181695;23481700;24190977;24715725;25502872;25576301;26375851;27846572;27862975;28228285;28467828;28832583;29242379;29508533;29550816;29557506;29632711;29786170;30315122;30401746;31844290;32157095;32350084;32357974;32368295;32502341;32938616;32983136;33141586;33356837;33627480;33717175;34171305;34211107;34509645;34932366;35051231;35154160;35580925;36010968;38102712;7478585;8666391;8798570;9430661;9499402",
        "class_list": "",
        "function": "EphB1 and EphA1 phosphorylate the Cx32CT domain residue Tyr(243) Unlike for Cx43, the tyrosine phosphorylation of the Cx32CT increased gap junction intercellular communication., [RefSeq, PubMed]; Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. [provided by RefSeq, Jul 2008]., [RefSeq]; Identification of tetracycline combinations as EphB1 tyrosine kinase inhibitors for treatment of neuropathic pain., [RefSeq, PubMed]; Peripheral EphrinB1/EphB1 signalling attenuates muscle hyperalgesia in MPS patients and a rat model of taut band-associated persistent muscle pain., [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Cognate/functional ephrin ligands for this receptor include EFNB1, EFNB2 and EFNB3. During nervous system development, regulates retinal axon guidance redirecting ipsilaterally ventrotemporal retinal ganglion cells axons at the optic chiasm midline. This probably requires repulsive interaction with EFNB2. In the adult nervous system together with EFNB3, regulates chemotaxis, proliferation and polarity of the hippocampus neural progenitors. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and synapse formation. May also regulate angiogenesis. More generally, may play a role in targeted cell migration and adhesion. Upon activation by EFNB1 and probably other ephrin-B ligands activates the MAPK/ERK and the JNK signaling cascades to regulate cell migration and adhesion respectively. Involved in the maintenance of the pool of satellite cells (muscle stem cells) by promoting their self-renewal and reducing their activation and differentiation (By similarity)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Recurring EPHB1 mutations in human cancers alter receptor signalling and compartmentalisation of colorectal cancer cells. Publication Status: Online-Only, [RefSeq, PubMed]; SUMOylation of EphB1 repressed activation of its downstream signaling molecule PKC-gamma, and consequently inhibited neuroblastoma tumorigenesis., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 5,
        "reported_mutagensis": 5,
        "reported_glycation": 0,
        "reported_snv": 161,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 4,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K593;B3KTB2;B5A969;O43569;O95142;O95143;Q0VG87",
        "ec_number_list": [
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.4.24.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.4.24.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "3.4.23.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0044877 protein-containing complex binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0008046 axon guidance receptor activity;GO:0005003 ephrin receptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030424 axon",
        "go_biological_process": "GO:0021934 hindbrain tangential cell migration;GO:0001525 angiogenesis;GO:0048013 ephrin receptor signaling pathway;GO:0050965 detection of temperature stimulus involved in sensory perception of pain;GO:0046777 protein autophosphorylation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.5,
        "record_id": "P54762-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1000000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NPA0-1",
        "uniprot_id": [
            {
                "id": "EMC7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NPA0",
                "type": "external"
            }
        ],
        "mass": 26471.0,
        "length": 242,
        "protein_name": "Endoplasmic reticulum membrane protein complex subunit 7",
        "gene_name": "EMC7",
        "organism": "Human",
        "refseq_name": "endoplasmic reticulum membrane protein complex subunit 7 precursor",
        "refseq_ac": [
            {
                "id": "NP_064539",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_064539",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EMC7; C11orf3; C15orf24; HT022; PRO1926",
        "gene_names_refseq": "C11orf3; C15orf24; EMC7; HT022; ORF1-FL1",
        "protein_names_uniprotkb": "Endoplasmic reticulum membrane protein complex subunit 7; ER membrane protein complex subunit 7",
        "protein_names_refseq": "UPF0480 protein C15orf24; chromosome 15 hypothetical ATG/GTP binding protein; endoplasmic reticulum membrane protein complex subunit 7 precursor; endoplasmic reticulum membrane protein complex subunit 7",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:56851)",
        "pathway_count": 1,
        "publication_count": 86,
        "publication_id_list": "10.1038/emboj.2013.79;10.1101/2023.09.13.557529;10873569;11237011;11584024;12496422;12975309;14563323;17165166;17825839;20112406;22119785;22898188;23584533;24366607;24715725;25418920;25469497;25576301;25645385;26154972;26811146;26929215;26992070;27452731;27600516;27846572;27920218;28063628;28228285;28649982;28832583;28834231;28904123;29242231;29242379;29393594;29557506;29632046;29632711;29786170;29809151;30192525;30315122;30410026;30415835;30779550;30833945;31154438;31530632;31844290;31848261;32111841;32157095;32265295;32350084;32357974;32387766;32439656;32459176;32488085;32502341;32897882;32938616;32983136;33298915;33592498;33912179;33968037;33981976;34087483;34171305;34211107;34932366;35051231;35318648;35580925;36010968;36215666;36241641;36284347;37938771;39894887;9103427;9570521;9647214",
        "class_list": "",
        "function": "Candidate modifier gene on the phenotypic expression of hypertrophy in patients with hyperthophic cardiomyopathy., [RefSeq, PubMed]; ER membrane protein complex subunit 4 (EMC4) and EMC7 support SV40 infection by promoting from the late endosome (LE) to the endoplasmic reticulum (ER) targeting of the virus. They do this by engaging LE-associated Rab7, to stabilize contact between the LE and ER. These EMC subunits also bind to the ER-resident fusion machinery component syntaxin18, which is required for SV40-arrival to the ER. Publication Status: Online-Only, [RefSeq, PubMed]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 7,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RC00;Q96ED5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030246 carbohydrate binding",
        "go_cellular_component": "GO:0072546 EMC complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence",
        "synthesized_glycan_count": 0,
        "hit_score": 9.4,
        "record_id": "Q9NPA0-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H6S3-1",
        "uniprot_id": [
            {
                "id": "ES8L2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H6S3",
                "type": "external"
            }
        ],
        "mass": 80621.0,
        "length": 715,
        "protein_name": "Epidermal growth factor receptor kinase substrate 8-like protein 2",
        "gene_name": "EPS8L2",
        "organism": "Human",
        "refseq_name": "epidermal growth factor receptor kinase substrate 8-like protein 2 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_073609",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_073609",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPS8L2; EPS8R2; PP13181",
        "gene_names_refseq": "DFNB106; EPS8L2; EPS8R2",
        "protein_names_uniprotkb": "Epidermal growth factor receptor kinase substrate 8-like protein 2; EPS8-like protein 2; EPS8-related protein 2; Epidermal growth factor receptor pathway substrate 8-related protein 2",
        "protein_names_refseq": "EPS8 like 2; EPS8-related protein 2; epidermal growth factor receptor kinase substrate 8-like protein 2 isoform 1; epidermal growth factor receptor kinase substrate 8-like protein 2; epidermal growth factor receptor pathway substrate 8-related protein 2",
        "tax_id": 9606,
        "disease": "autosomal recessive nonsyndromic deafness 106 (Disease Ontology:DOID:0080261); alcohol use disorder (Disease Ontology:DOID:1574)",
        "pathway": " (hsa:64787);  (R-HSA-9662360);  (R-HSA-9662361)",
        "pathway_count": 3,
        "publication_count": 43,
        "publication_id_list": "10025409;10821263;11163272;11237011;12620401;14565974;15498874;16083285;17693683;18212344;18220336;18452278;18669648;19651622;20068231;23186163;24275569;26282398;26992070;27452731;28281779;29237092;29242379;29485866;29557506;29786170;30429286;30484775;30833945;31154438;31844290;31848261;32938616;33537174;33592498;33912179;33968037;34171305;34185709;35051231;35580925;36215666;36284347",
        "class_list": "",
        "function": "Frame-shift variant (c.1014delC; p.Ser339Alafs*15) was identified in EPS8L2, encoding Epidermal growth factor receptor Pathway Substrate 8 L2, a protein of hair cells' stereocilia previously implicated in progressive deafness in the mouse Publication Status: Online-Only, [RefSeq, PubMed]; Stimulates guanine exchange activity of SOS1. May play a role in membrane ruffling and remodeling of the actin cytoskeleton. In the cochlea, is required for stereocilia maintenance in adult hair cells (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes a member of the EPS8 gene family. The encoded protein, like other members of the family, is thought to link growth factor stimulation to actin organization, generating functional redundancy in the pathways that regulate actin cytoskeletal remodeling. [provided by RefSeq, Dec 2008]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 17,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KSX1;B7ZKL3;Q53GM8;Q8WYW7;Q96K06;Q9H6K9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0045296 cadherin binding",
        "go_cellular_component": "GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0070062 extracellular exosome;GO:0031982 vesicle;GO:0032587 ruffle membrane",
        "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0007605 sensory perception of sound;GO:1900029 positive regulation of ruffle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 4.6,
        "record_id": "Q9H6S3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5T7M9-1",
        "uniprot_id": [
            {
                "id": "DIK1A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5T7M9",
                "type": "external"
            }
        ],
        "mass": 49024.0,
        "length": 428,
        "protein_name": "Divergent protein kinase domain 1A",
        "gene_name": "DIPK1A",
        "organism": "Human",
        "refseq_name": "divergent protein kinase domain 1A isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001006606",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006606",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "DIPK1A; FAM69A",
        "gene_names_refseq": "DIPK1A; FAM69A",
        "protein_names_uniprotkb": "Divergent protein kinase domain 1A; Protein FAM69A",
        "protein_names_refseq": "divergent protein kinase domain 1A isoform 1; family with sequence similarity 69 member A; protein FAM69A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:388650)",
        "pathway_count": 1,
        "publication_count": 21,
        "publication_id_list": "10.1038/emboj.2013.79;11237011;19506219;19834503;20087403;23481700;23584533;25880248;26992070;27920218;28832583;28834231;29242379;32157095;34087483;34171305;34211107;34357683;35051231;35251023;36010968",
        "class_list": "",
        "function": "An analysis and fine mapping of GFI-EVI5-RPL5-FAM69A locus, genotyping eight Tag-single nucleotide polymorphisms in 732 multiple sclerosis patients and 974 controls from Spain, was performed. GeneRIF: Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study and meta-analysis of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes a member of the FAM69 family of cysteine-rich type II transmembrane proteins. These proteins localize to the endoplasmic reticulum but their specific functions are unknown. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IRV2",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 2.6,
        "record_id": "Q5T7M9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q52LR7-1",
        "uniprot_id": [
            {
                "id": "EPC2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q52LR7",
                "type": "external"
            }
        ],
        "mass": 91095.0,
        "length": 807,
        "protein_name": "Enhancer of polycomb homolog 2",
        "gene_name": "EPC2",
        "organism": "Human",
        "refseq_name": "enhancer of polycomb homolog 2",
        "refseq_ac": [
            {
                "id": "NP_056445",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_056445",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPC2",
        "gene_names_refseq": "EPC-LIKE; EPC2",
        "protein_names_uniprotkb": "Enhancer of polycomb homolog 2; EPC-like",
        "protein_names_refseq": "enhancer of polycomb homolog 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26122)",
        "pathway_count": 1,
        "publication_count": 60,
        "publication_id_list": "11237011;18330920;18452278;18669648;19413330;19664995;20068231;23186163;23481700;24166297;25218447;26154972;26992070;27862975;28228285;28832583;29237092;29242379;29351928;29557506;29786170;30059200;30429286;30833945;31154438;31217245;31492838;31637018;31844290;31848261;32157095;32357974;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33912179;33936100;33968037;34019948;34087483;34171305;34846842;35051231;35254053;35289036;35318648;35494241;35580925;36010968;36215666;36241641;37938771;38665916;40307207;40596516",
        "class_list": "",
        "function": "EPC1 and EPC2 are components of a complex that directly or indirectly serves to prevent MYC accumulation and AML cell apoptosis, thus sustaining oncogenic potential, [RefSeq, PubMed]; May play a role in transcription or DNA repair., [UniProtKB]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 7,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B3KWT7;D3DP89;Q7L9J1;Q96RR7;Q9NUT8;Q9NVR1;Q9UFM9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0035267 NuA4 histone acetyltransferase complex;GO:0032777 piccolo histone acetyltransferase complex",
        "go_biological_process": "GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0006325 chromatin organization",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q52LR7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P12318-1",
        "uniprot_id": [
            {
                "id": "FCG2A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P12318",
                "type": "external"
            }
        ],
        "mass": 35001.0,
        "length": 317,
        "protein_name": "Low affinity immunoglobulin gamma Fc region receptor II-a",
        "gene_name": "FCGR2A",
        "organism": "Human",
        "refseq_name": "low affinity immunoglobulin gamma Fc region receptor II-a isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001129691",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129691",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FCGR2A; CD32; FCG2; FCGR2A1; IGFR2",
        "gene_names_refseq": "CD32A; CD32; CDw32; FCG2; FCGR2A1; FCGR2A; FCGR2; FcGR; FcgammaRIIa; IGFR2",
        "protein_names_uniprotkb": "Low affinity immunoglobulin gamma Fc region receptor II-a; CDw32; Fc-gamma RII-a; Fc-gamma-RIIa; FcRII-a; IgG Fc receptor II-a",
        "protein_names_refseq": "Fc fragment of IgG receptor IIa; Fc fragment of IgG, low affinity IIa, receptor (CD32); Fc gamma receptor RIIa3; Immunoglobulin G Fc receptor II; fc-gamma-RIIa; fcRII-a; igG Fc receptor II-a; low affinity immunoglobulin gamma Fc region receptor II-a isoform 1 precursor; low affinity immunoglobulin gamma Fc region receptor II-a",
        "tax_id": 9606,
        "disease": "diffuse large B-cell lymphoma (Disease Ontology:DOID:0050745); stroke (Disease Ontology:DOID:0051061); non-Hodgkin lymphoma (Disease Ontology:DOID:0060060); thrombosis (Disease Ontology:DOID:0060903); lupus nephritis (Disease Ontology:DOID:0080162); haemophilus meningitis (Disease Ontology:DOID:0080179); lymphoid leukemia (Disease Ontology:DOID:1037); hemolytic disease of the fetus (Disease Ontology:DOID:1098); factor VIII deficiency (Disease Ontology:DOID:12134); common variable immunodeficiency (Disease Ontology:DOID:12177); dengue disease (Disease Ontology:DOID:12205); dengue hemorrhagic fever (Disease Ontology:DOID:12206); neutropenia (Disease Ontology:DOID:1227); malaria (Disease Ontology:DOID:12365); crescentic glomerulonephritis (Disease Ontology:DOID:13139); temporal arteritis (Disease Ontology:DOID:13375); Plasmodium falciparum malaria (Disease Ontology:DOID:14067); cystic fibrosis (Disease Ontology:DOID:1485); arthus reaction (Disease Ontology:DOID:1556); respiratory system disease (Disease Ontology:DOID:1579); diffuse scleroderma (Disease Ontology:DOID:1580); thrombocytopenia (Disease Ontology:DOID:1588); epilepsy (Disease Ontology:DOID:1826); atherosclerosis (Disease Ontology:DOID:1936); multiple sclerosis (Disease Ontology:DOID:2377); asthma (Disease Ontology:DOID:2841); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); hemolytic anemia (Disease Ontology:DOID:583); lymphopenia (Disease Ontology:DOID:614); rheumatoid arthritis (Disease Ontology:DOID:7148); osteoarthritis (Disease Ontology:DOID:8398); chronic myeloid leukemia (Disease Ontology:DOID:8552); ulcerative colitis (Disease Ontology:DOID:8577); Crohn's disease (Disease Ontology:DOID:8778); psoriasis (Disease Ontology:DOID:8893); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); systemic lupus erythematosus (Disease Ontology:DOID:9074); multiple myeloma (Disease Ontology:DOID:9538)",
        "pathway": " (hsa:2212);  (R-HSA-2029481);  (R-HSA-2029482);  (R-HSA-2029485);  (R-HSA-6798695);  (R-HSA-9664323)",
        "pathway_count": 6,
        "publication_count": 145,
        "publication_id_list": "10219243;10224668;10331870;10397151;10496324;10559936;10579907;10724160;10781580;10861086;10878810;10995437;11157975;11231582;11237011;11276226;11278486;11329366;11340081;11397093;11425868;11553796;11711607;11747816;11749377;11804587;11829459;11854399;12055636;12105426;12117970;12189515;12213210;12235133;12417718;12660731;12690104;12743368;12869549;1314888;1372004;14676198;15040784;15161916;15294978;15452139;15536084;15657136;15809313;15879134;16262445;16497229;16546099;16641196;16678913;16702231;16880808;16921024;17188549;17202194;17308335;17590538;18070890;18391171;18818202;19011614;19741094;19955216;21037092;21419341;23650620;23675550;2474607;2526077;2529342;25345863;2824655;28566370;29557506;2965389;31611695;31844290;32157095;32350084;32357974;32387766;32897882;32938616;32983136;33091337;33392160;33936100;33968037;3402431;34357683;34509645;34932366;35051231;35154160;35251023;35580925;36215666;37421619;38335505;38408113;38455048;38544414;38594587;7487883;7512959;7516890;7517665;7521687;7522622;7530449;7718892;7848918;8132624;8226994;8228618;8327478;8327512;8340414;8541526;8611682;8636449;8657103;8692836;8756631;8809042;8862523;8986718;9000504;9042338;9050880;9162098;9314552;9600938;9705280;9799231;9843499;9857068;9883880;9885284;9973503",
        "class_list": "",
        "function": "Binds to the Fc region of immunoglobulins gamma. Low affinity receptor. By binding to IgG it initiates cellular responses against pathogens and soluble antigens. Promotes phagocytosis of opsonized antigens., [UniProtKB, PubMed]; CD32 captures committed haemogenic endothelial cells during human embryonic development., [RefSeq, PubMed]; Genetic variation of FcgammaRIIa induces higher uptake of Leishmania infantum and modulates cytokine production by adherent mononuclear cells in vitro. Publication Status: Online-Only, [RefSeq, PubMed]; New candidate SNPs for genetic association with Alzheimer's disease: a linkage disequilibrium analysis for the FCGRIIB and PILRA genes. Publication Status: Online-Only, [RefSeq, PubMed]; Platelet FcgammaRIIa expression in patients with stable coronary artery disease., [RefSeq, PubMed]; Regulatory mechanism of FCGR2A in macrophage polarization and its effects on intervertebral disc degeneration., [RefSeq, PubMed]; This gene encodes one member of a family of immunoglobulin Fc receptor genes found on the surface of many immune response cells. The protein encoded by this gene is a cell surface receptor found on phagocytic cells such as macrophages and neutrophils, and is involved in the process of phagocytosis and clearing of immune complexes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 10,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 39,
        "disease_count": 39,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8WUN1;Q8WW64",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019864 IgG binding;GO:0019770 IgG receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009897 external side of plasma membrane;GO:0030667 secretory granule membrane",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0050766 positive regulation of phagocytosis;GO:0032760 positive regulation of tumor necrosis factor production;GO:0001788 antibody-dependent cellular cytotoxicity",
        "synthesized_glycan_count": 0,
        "hit_score": 18.8,
        "record_id": "P12318-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43402-1",
        "uniprot_id": [
            {
                "id": "EMC8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43402",
                "type": "external"
            }
        ],
        "mass": 23773.0,
        "length": 210,
        "protein_name": "ER membrane protein complex subunit 8",
        "gene_name": "EMC8",
        "organism": "Human",
        "refseq_name": "ER membrane protein complex subunit 8 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001135760",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135760",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EMC8; C16orf2; C16orf4; COX4AL; COX4NB; FAM158B; NOC4",
        "gene_names_refseq": "C16orf2; C16orf4; COX4NB; EMC8; FAM158B; NOC4",
        "protein_names_uniprotkb": "ER membrane protein complex subunit 8; Neighbor of COX4; Protein FAM158B",
        "protein_names_refseq": "COX4 neighbor; ER membrane protein complex subunit 8 isoform 2; family with sequence similarity 158, member B; neighbor of COX4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10328)",
        "pathway_count": 1,
        "publication_count": 62,
        "publication_id_list": "10337626;11237011;19724895;19851296;20198315;22119785;23481700;24715725;25505266;25576301;26154972;26375851;26992070;27846572;28218747;28228285;28514659;28832583;28834231;28904123;29242231;29242379;29351928;29437277;29508533;29809151;30415835;30833945;31530632;31611695;31844290;31848261;31937595;31998317;32157095;32350084;32387766;32439656;32459176;32502341;32897882;32938616;32983136;33141586;33298915;33592498;33912179;33936100;33968037;33981976;34087483;34171305;34211107;34509645;35051231;35580925;36010968;36215666;36241641;37938771;38665916;40596516",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed, PubMed]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 8,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "C9JB21",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0072546 EMC complex;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane",
        "go_biological_process": "GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "O43402-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75355-1",
        "uniprot_id": [
            {
                "id": "ENTP3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75355",
                "type": "external"
            }
        ],
        "mass": 59105.0,
        "length": 529,
        "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 3",
        "gene_name": "ENTPD3",
        "organism": "Human",
        "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001239",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001239",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ENTPD3; CD39L3",
        "gene_names_refseq": "CD39L3; ENTPD3; HB6; NTPDase-3",
        "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 3; 3.6.1.5; CD39 antigen-like 3; Ecto-ATP diphosphohydrolase 3; Ecto-ATPDase 3; Ecto-ATPase 3; Ecto-apyrase 3; HB6; NTPDase 3; eNTPDase-3",
        "protein_names_refseq": "CD39 antigen-like 3; NTPDase 3; eNTPDase-3; ecto-ATP diphosphohydrolase 3; ecto-ATPDase 3; ecto-ATPase 3; ecto-apyrase 3; ectonucleoside triphosphate diphosphohydrolase 3 isoform 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:956);  (R-HSA-8850843)",
        "pathway_count": 2,
        "publication_count": 53,
        "publication_id_list": "10.1101/2023.09.13.557529;10231536;10400613;10470077;10510450;10681547;10866813;10948193;11041856;11041857;11237011;11278936;11300774;11927941;11929769;12694193;12706347;12888562;14529283;14675084;15122917;15130768;15966724;16338080;17095758;17502665;18404400;18404504;18404510;19640930;19743837;20682839;21074248;21586362;22169232;23241884;24715725;26018728;28472257;28956227;31154438;31998317;32125861;33968037;34380694;37074911;37076930;8955160;8995405;9364474;9556635;9675246;9676430",
        "class_list": "",
        "function": "Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs) (PubMed:10231536, PubMed:11300774, PubMed:15966724, PubMed:9675246). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:10231536, PubMed:11300774, PubMed:15966724, PubMed:9675246). This activity contributes to the regulation of extracellular levels of nucleotides (PubMed:10231536, PubMed:11300774, PubMed:15966724, PubMed:9675246). Has a preference for the hydrolysis of ATP (PubMed:10231536). Does not hydrolyzes AMP (PubMed:9675246)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; Despite the increased level of NTPDase1 and NTPDase3 mRNA expression in chondrogenically induced MSCs, their activity toward ATP remains quite low., [RefSeq, PubMed]; ENTPD3 Marks Mature Stem Cell-Derived beta-Cells Formed by Self-Aggregation In Vitro., [RefSeq, PubMed]; NTPDase2 and -3 are ecto-enzymes expressed in the enteric nervous system. Both enzymes confer protection against gut inflammation in experimental colitis and exhibit alterations in Crohn's disease. These observations suggest that purinergic signalling modulated by E-NTPDases governs neuro-immune interactions that are relevant in Crohn's disease., [RefSeq, PubMed]; Silencing NTPDase3 activity rehabilitates the osteogenic commitment of post-menopausal stem cell bone progenitors. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a plasma membrane-bound divalent cation-dependent E-type nucleotidase. The encoded protein is involved in the regulation of extracellular levels of ATP by hydrolysis of it and other nucleotides. Multiple transcript variants have been described. [provided by RefSeq, May 2014]., [RefSeq]",
        "predicted_glycosites": 4,
        "predicted_n_glycosites": 4,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 4,
        "mined_n_glycosites": 3,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 1,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
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        ],
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        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "GO:0009203 ribonucleoside triphosphate catabolic process;GO:0009191 ribonucleoside diphosphate catabolic process;GO:0009134 nucleoside diphosphate catabolic process",
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    {
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        "uniprot_id": [
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                "id": "NSMA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NY59",
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        ],
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        "length": 655,
        "protein_name": "Sphingomyelin phosphodiesterase 3",
        "gene_name": "SMPD3",
        "organism": "Human",
        "refseq_name": "sphingomyelin phosphodiesterase 3",
        "refseq_ac": [
            {
                "id": "NP_061137",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_061137",
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        ],
        "gene_names_uniprotkb": "SMPD3",
        "gene_names_refseq": "NSMASE2; SMPD3",
        "protein_names_uniprotkb": "Sphingomyelin phosphodiesterase 3; 3.1.4.12; Neutral sphingomyelinase 2; Neutral sphingomyelinase II; nSMase-2; nSMase2",
        "protein_names_refseq": "nSMase-2; neutral sphingomyelinase 2; neutral sphingomyelinase II; sphingomyelin phosphodiesterase 3",
        "tax_id": 9606,
        "disease": "osteogenesis imperfecta type 3 (Disease Ontology:DOID:0110339); osteogenesis imperfecta type 2 (Disease Ontology:DOID:0110341); osteogenesis imperfecta (Disease Ontology:DOID:12347); transient cerebral ischemia (Disease Ontology:DOID:224); chronic obstructive pulmonary disease (Disease Ontology:DOID:3083); pulmonary hypertension (Disease Ontology:DOID:6432); hypopituitarism (Disease Ontology:DOID:9406); pulmonary emphysema (Disease Ontology:DOID:9675)",
        "pathway": " (hsa:55512);  (R-HSA-5626978);  (R-HSA-9840310)",
        "pathway_count": 3,
        "publication_count": 119,
        "publication_id_list": "10191093;10196694;10406958;10781797;10823942;10861246;10942779;10993717;11237011;11350180;11435466;11489889;11707436;11784319;12374214;12391233;12510003;12518053;12566438;12594539;12662933;12885774;12888274;12909021;1352293;1352993;14741383;15003450;15051724;15213228;15458386;15714521;15773042;15845354;16229686;16230343;1634229;16478472;16517606;16595074;16698036;1670590;1678251;17105727;1718266;1720305;17349629;1740330;1756715;1840600;18524657;1889421;1907800;1915858;19405096;19836391;2001789;20080539;20728381;235289;239890;24275569;24715725;2562955;25892735;2717620;28126847;28904123;29443946;29557506;2960521;2965147;29692406;2970528;2971395;29747811;2976757;29769354;29802621;3014515;3048308;3136930;31495489;31530632;3158659;32938616;33912179;3456607;34584229;34951654;36768348;37640282;38542220;39940;5135907;5164093;527942;5822067;7504405;7628016;7730378;7744740;7852280;8281145;8370580;8399327;8573994;8591035;8663014;8663398;8804427;8808629;8889578;8955159;8985184;9217013;9338580;9520418;9521684",
        "class_list": "glycogene",
        "function": "Activation of neutral sphingomyelinase 2 through hyperglycemia contributes to endothelial apoptosis via vesicle-bound intercellular transfer of ceramides. Publication Status: Online-Only, [RefSeq, PubMed]; Catalyzes the hydrolysis of sphingomyelin to form ceramide and phosphocholine. Ceramide mediates numerous cellular functions, such as apoptosis and growth arrest, and is capable of regulating these 2 cellular events independently. Also hydrolyzes sphingosylphosphocholine. Regulates the cell cycle by acting as a growth suppressor in confluent cells. Probably acts as a regulator of postnatal development and participates in bone and dentin mineralization (PubMed:10823942, PubMed:14741383, PubMed:15051724). Binds to anionic phospholipids (APLs) such as phosphatidylserine (PS) and phosphatidic acid (PA) that modulate enzymatic activity and subcellular location. May be involved in IL-1-beta-induced JNK activation in hepatocytes (By similarity). May act as a mediator in transcriptional regulation of NOS2/iNOS via the NF-kappa-B activation under inflammatory conditions (By similarity)., [UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]; Inhibition of Neutral Sphingomyelinase 2 by Novel Small Molecule Inhibitors Results in Decreased Release of Extracellular Vesicles by Vascular Smooth Muscle Cells and Attenuated Calcification. Publication Status: Online-Only, [RefSeq, PubMed]; NSMase2 is a structural gene for nSMase, acts as a bona fide N-SMase in cells, and has a role in the regulation of cell growth and cell signaling, [RefSeq, PubMed]; Neutral sphingomyelinase mediates the co-morbidity trias of alcohol abuse, major depression and bone defects., [RefSeq, PubMed]; Regulated translocation of neutral sphingomyelinase-2 to the plasma membrane drives insulin resistance in steatotic hepatocytes., [RefSeq, PubMed]; The Role of Neutral Sphingomyelinase-2 (NSM2) in the Control of Neutral Lipid Storage in T Cells. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "reported_snv": 862,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "secondary_ac_list": "B7ZL82;Q2M1S8",
        "ec_number_list": [
            {
                "id": "3.1.4.12",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.12",
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            {
                "id": "3.1.4.3",
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            {
                "id": "3.1.4.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.38",
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            },
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
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        ],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0046872 metal ion binding;GO:0008081 phosphoric diester hydrolase activity;GO:0001786 phosphatidylserine binding;GO:0004767 sphingomyelin phosphodiesterase activity",
        "go_cellular_component": "GO:0000139 Golgi membrane;GO:0005576 extracellular region;GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0006685 sphingomyelin catabolic process;GO:0006684 sphingomyelin metabolic process;GO:1903543 positive regulation of exosomal secretion;GO:0006665 sphingolipid metabolic process",
        "synthesized_glycan_count": 0,
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    {
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        "uniprot_id": [
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                "id": "LRRF1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q32MZ4",
                "type": "external"
            }
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        "mass": 89253.0,
        "length": 808,
        "protein_name": "Leucine-rich repeat flightless-interacting protein 1",
        "gene_name": "LRRFIP1",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat flightless-interacting protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001131022",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001131022",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "LRRFIP1; GCF2; TRIP",
        "gene_names_refseq": "FLAP-1; FLAP1; FLIIAP1; GCF-2; GCF2; HUFI-1; LRRFIP1; TRIP",
        "protein_names_uniprotkb": "Leucine-rich repeat flightless-interacting protein 1; GC-binding factor 2; LRR FLII-interacting protein 1; TAR RNA-interacting protein",
        "protein_names_refseq": "GC-binding factor 2; LRR FLII-interacting protein 1; NEDD8-conjugating enzyme; TAR RNA-interacting protein; leucine rich repeat (in FLII) interacting protein 1; leucine-rich repeat flightless-interacting protein 1 isoform 1; leucine-rich repeat flightless-interacting protein 1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9208);  (R-HSA-1839117);  (R-HSA-3134973);  (R-HSA-5655302)",
        "pathway_count": 4,
        "publication_count": 147,
        "publication_id_list": "10364563;10366446;10480903;10579907;10652257;10688839;10887137;10918587;10935490;11157491;11237011;11429702;11689702;11739186;12124177;12393597;14522076;14534538;14660670;15034873;15050920;15173161;15448205;15609342;15800673;16091734;16199883;16844695;16946300;16959974;16964243;16990252;17081983;17505008;17533378;17698633;18205209;18337450;18373495;18381441;18412956;18552176;18669648;18757403;19103595;19147536;19265123;19369959;19381019;19690332;19749790;19809159;19874848;19946327;20068231;20094046;20179196;20226962;20453844;20709759;21160078;21330321;21406692;21666749;21711248;23035229;23099021;23186163;23301498;23481700;24275569;24366607;25114211;25502872;25880248;26768311;26853435;26992070;27452731;27600516;27846572;27862975;27920218;28218747;28228285;28510447;28832583;28834231;28904123;29242379;29351928;29393594;29493099;29508533;29557506;29996558;30315122;30379171;30429286;30524438;30709060;30779550;31154438;31530632;31717259;31844290;31848261;31998317;32157095;32350084;32387766;32488085;32502341;32938616;32983136;33123756;33141586;33298915;33592498;33717175;33912179;33968037;33981976;34078123;34087483;34932366;35051231;35132862;35154160;35251023;35338570;35580925;36010968;36215666;36241641;36284347;38665916;40307207;40914422;9425908;9541017;9576949;9671805;9705290;9716603;9857065;9949182",
        "class_list": "",
        "function": "LRRFIP1, an epigenetically regulated gene, is a prognostic biomarker and predicts malignant phenotypes of glioma., [RefSeq, PubMed]; LRRFIP1/GCF2 is a bioregulator in multidisciplinary systems of the human body and its dysregulation can cause diverse human diseases. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Results show that LRRFIP-1 is mainly produced by keratinocytes in the unwounded skin but is upregulated in both keratinocytes and fibroblasts in response to wounding, suggesting a role in the wound repair process. Publication Status: Online-Only, [RefSeq, PubMed]; Transcriptional repressor which preferentially binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate expression of TNF, EGFR and PDGFA. May control smooth muscle cells proliferation following artery injury through PDGFA repression. May also bind double-stranded RNA. Positively regulates Toll-like receptor (TLR) signaling in response to agonist probably by competing with the negative FLII regulator for MYD88-binding., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
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        "secondary_ac_list": "E9PGZ2;O75766;O75799;Q32MZ5;Q53T49;Q6PKG2;Q9Y607",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0042803 protein homodimerization activity;GO:0045296 cadherin binding;GO:0001227 DNA-binding transcription repressor activity, RNA polymerase II-specific;GO:0003725 double-stranded RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0005856 cytoskeleton",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 15.2,
        "record_id": "Q32MZ4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "FA78A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5JUQ0",
                "type": "external"
            }
        ],
        "mass": 31968.0,
        "length": 283,
        "protein_name": "Protein FAM78A",
        "gene_name": "FAM78A",
        "organism": "Human",
        "refseq_name": "protein FAM78A isoform 1",
        "refseq_ac": [
            {
                "id": "NP_203745",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_203745",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM78A; C9orf59",
        "gene_names_refseq": "C9orf59; FAM78A",
        "protein_names_uniprotkb": "Protein FAM78A",
        "protein_names_refseq": "protein FAM78A isoform 1; protein FAM78A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:286336)",
        "pathway_count": 1,
        "publication_count": 38,
        "publication_id_list": "10.1038/emboj.2013.79;11237011;23481700;23584533;24715725;25418920;25880248;26154972;26992070;27846572;27920218;28218747;28228285;28832583;28834231;28904123;29242379;29317506;29437277;29493099;29557506;30315122;31154438;31844290;31848261;32157095;32350084;32357974;32502341;32983136;33912179;34357683;34561969;35051231;35154160;35251023;35580925;36284347",
        "class_list": "",
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        "predicted_glycosites": 0,
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        "secondary_ac_list": "Q86VQ9;Q9H7P4",
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        "go_molecular_function": "",
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        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
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        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
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    },
    {
        "uniprot_canonical_ac": "Q14320-1",
        "uniprot_id": [
            {
                "id": "FA50A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14320",
                "type": "external"
            }
        ],
        "mass": 40242.0,
        "length": 339,
        "protein_name": "Protein FAM50A",
        "gene_name": "FAM50A",
        "organism": "Human",
        "refseq_name": "protein FAM50A",
        "refseq_ac": [
            {
                "id": "NP_004690",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004690",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM50A; DXS9928E; HXC26; XAP5",
        "gene_names_refseq": "9F; DXS9928E; FAM50A; HXC-26; HXC26; MRXSA; XAP5",
        "protein_names_uniprotkb": "Protein FAM50A; Protein HXC-26; Protein XAP-5",
        "protein_names_refseq": "Armfield X-linked mental retardation syndrome; protein FAM50A; protein XAP-5",
        "tax_id": 9606,
        "disease": "Armfield syndrome (Disease Ontology:DOID:0050764)",
        "pathway": " (hsa:9130);  (R-HSA-72163)",
        "pathway_count": 2,
        "publication_count": 134,
        "publication_id_list": "10882114;11014198;11101529;11233976;11237011;11991638;12176931;12411573;12414731;12477934;14625303;14713954;16314458;16809785;17095540;17332742;17606899;18322460;18593880;19103666;19165350;19536130;20068231;20423332;20980672;21536652;2176635;22110043;22365833;22959432;22961380;23222130;23236153;23345524;24196718;24304693;24448447;24714562;24737827;24914973;25555158;25576301;2558966;26385511;26420826;26728094;26811146;26969736;26992070;27377154;27459055;27600516;27683217;27846572;28062851;28076346;28218747;28502770;28781166;28832583;28834231;28904123;29242379;29301961;29360106;29361316;29493099;29557506;29632046;2963332;29786170;29789417;30315122;30315277;30379171;30410026;30429286;30705154;30728453;30765414;30975767;31154438;31217245;31409651;31530632;31844290;31848261;31998317;32157095;32179686;32329775;32387766;32488085;32494006;32703943;32897882;32938616;32983136;33214551;33243851;33298915;33392160;33446560;33592498;33912179;33968037;34019948;34171305;34301950;34561969;34822310;35051231;35318648;35385551;35580925;36010968;36284347;36834630;37393403;3757028;37938771;8566756;8608946;8733135;9016565;9039504;9242493;9339379;9512519;9524131;9539711;9671485;9701291;9731529",
        "class_list": "",
        "function": "Mutations in FAM50A suggest that Armfield XLID syndrome is a spliceosomopathy. Publication Status: Online-Only, [RefSeq, PubMed]; Probably involved in the regulation of pre-mRNA splicing., [UniProtKB, PubMed]; Proto-Oncogene FAM50A Can Regulate the Immune Microenvironment and Development of Hepatocellular Carcinoma In Vitro and In Vivo. Publication Status: Online-Only, [RefSeq, PubMed]; This gene belongs to the FAM50 family. The encoded protein is highly conserved in length and sequence across different species. It is a basic protein containing a nuclear localization signal, and may function as a DNA-binding protein or a transcriptional factor. [provided by RefSeq, Sep 2009]., [RefSeq]; Upregulation of FAM50A promotes cancer development. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "reported_phosphosites": 4,
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        "secondary_ac_list": "A8KAQ4;B2R997;Q5HY37;Q6PJH5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm",
        "go_biological_process": "GO:0006397 mRNA processing;GO:0007283 spermatogenesis;GO:0008380 RNA splicing;GO:0006325 chromatin organization;GO:0043484 regulation of RNA splicing",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "Q14320-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9C0D9-1",
        "uniprot_id": [
            {
                "id": "EPT1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9C0D9",
                "type": "external"
            }
        ],
        "mass": 45229.0,
        "length": 397,
        "protein_name": "Ethanolaminephosphotransferase 1",
        "gene_name": "SELENOI",
        "organism": "Human",
        "refseq_name": "ethanolaminephosphotransferase 1",
        "refseq_ac": [
            {
                "id": "NP_277040",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_277040",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SELENOI; EPT1; KIAA1724; SELI",
        "gene_names_refseq": "EPT1; SELENOI; SELI; SEPI; SPG81",
        "protein_names_uniprotkb": "Ethanolaminephosphotransferase 1; 2.7.8.1; SelI; Selenoprotein I; hEPT1",
        "protein_names_refseq": "ethanolaminephosphotransferase 1 (CDP-ethanolamine-specific); ethanolaminephosphotransferase 1; hEPT1",
        "tax_id": 9606,
        "disease": "hereditary spastic paraplegia 81 (Disease Ontology:DOID:0112349)",
        "pathway": " (hsa:85465);  (R-HSA-1483213)",
        "pathway_count": 2,
        "publication_count": 54,
        "publication_id_list": "10191259;10893425;11044454;11237011;12216837;12221122;12775843;15175005;17132865;17478478;18583706;19915674;22223895;22241472;25645385;25880248;25892735;26992070;27645994;28052917;28228285;28467828;28834231;28904123;29101747;29242379;29437277;29500230;29557506;30410026;31092671;31154438;31844290;32350084;32357974;32938616;33298915;33633747;33691108;33912179;33936100;34185709;34357683;34681834;34932366;35051231;35154160;35580925;36007576;36010968;36241641;36942482;36963501;9083101",
        "class_list": "",
        "function": "A novel homozygous synonymous splicing variant in SELENOI gene causes spastic paraplegia 81., [RefSeq, PubMed]; Biology and Roles in Diseases of Selenoprotein I Characterized by Ethanolamine Phosphotransferase Activity and Antioxidant Potential. Review article, [RefSeq, PubMed]; Ethanolaminephosphotransferase that catalyzes the transfer of phosphoethanolamine (PE) from CDP-ethanolamine to lipid acceptors, the final step in the synthesis of PE via the 'Kennedy' pathway (PubMed:17132865, PubMed:28052917, PubMed:29500230). PE is the second most abundant phospholipid of membranes in mammals and is involved in various membrane-related cellular processes (PubMed:17132865). The enzyme is critical for the synthesis of several PE species and also catalyzes the synthesis of plasmanyl-PE, a lipid required for proper myelination and neurodevelopment, from 1-alkyl-2-acylglycerol (PubMed:29500230)., [UniProtKB, PubMed, PubMed, PubMed]; Intracellular localization of human selenoprotein SelI and the degree of expression of its gene in different human tumor cell lines, [RefSeq, PubMed]; Roles for Selenoprotein I and Ethanolamine Phospholipid Synthesis in T Cell Activation. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Selenoprotein I (selenoi) as a critical enzyme in the central nervous system., [RefSeq, PubMed]; The multi-pass transmembrane protein encoded by this gene belongs to the CDP-alcohol phosphatidyltransferase class-I family. It catalyzes the transfer of phosphoethanolamine from CDP-ethanolamine to diacylglycerol to produce phosphatidylethanolamine, which is involved in the formation and maintenance of vesicular membranes, regulation of lipid metabolism, and protein folding. This protein is a selenoprotein, containing the rare selenocysteine (Sec) amino acid at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jul 2016]., [RefSeq]; These studies define the first human disorder arising due to defective CDP-ethanolamine biosynthesis and provide new insight into the role of Kennedy pathway components in human neurological function, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q63ZE3",
        "ec_number_list": [
            {
                "id": "2.7.8.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.1",
                "type": "external"
            },
            {
                "id": "2.7.8.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.2",
                "type": "external"
            },
            {
                "id": "2.7.8.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.8.22",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0004307 ethanolaminephosphotransferase activity;GO:0016780 phosphotransferase activity, for other substituted phosphate groups",
        "go_cellular_component": "GO:0005794 Golgi apparatus;GO:0005789 endoplasmic reticulum membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0008611 ether lipid biosynthetic process;GO:0042552 myelination;GO:0006646 phosphatidylethanolamine biosynthetic process;GO:0008654 phospholipid biosynthetic process;GO:0046474 glycerophospholipid biosynthetic process",
        "synthesized_glycan_count": 0,
        "hit_score": 5.5,
        "record_id": "Q9C0D9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14156-1",
        "uniprot_id": [
            {
                "id": "EFR3A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14156",
                "type": "external"
            }
        ],
        "mass": 92924.0,
        "length": 821,
        "protein_name": "Protein EFR3 homolog A",
        "gene_name": "EFR3A",
        "organism": "Human",
        "refseq_name": "protein EFR3 homolog A isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001310482",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001310482",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EFR3A; KIAA0143",
        "gene_names_refseq": "EFR3A",
        "protein_names_uniprotkb": "Protein EFR3 homolog A; Protein EFR3-like",
        "protein_names_refseq": "protein EFR3 homolog A isoform 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:23167)",
        "pathway_count": 1,
        "publication_count": 82,
        "publication_id_list": "11237011;18220336;18578522;18669648;18691976;19651622;20068231;21654843;23186163;23229899;24715725;24860643;25380825;25418920;25576301;25608530;25645385;25880248;25892735;26154972;26375851;26571211;26992070;27600516;27846572;27920218;28228285;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;29769354;29786170;30315122;30833945;31154438;31217245;31844290;31848261;31937595;31998317;32157095;32161166;32350084;32357974;32387766;32502341;32938616;32983136;33123756;33141586;33298915;33592498;33691108;33717175;33912179;33936100;33968037;33981976;34087483;34211107;34357683;34405274;34504076;34509645;34932366;35051231;35318648;35580925;36010968;36241641;36284347;36581221;37217939;37880612;38063110",
        "class_list": "",
        "function": "Circular RNA EFR3A promotes nasopharyngeal carcinoma progression through modulating the miR-654-3p/EFR3A axis. Publication Status: Online-Only, [RefSeq, PubMed]; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis. In the complex, EFR3A probably acts as the membrane-anchoring component. Also involved in responsiveness to G-protein-coupled receptors; it is however unclear whether this role is direct or indirect., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; EFR3A: a new raft domain organizing protein? Publication Status: Online-Only, [RefSeq, PubMed]; Oncogenic KRAS is dependent upon an EFR3A-PI4KA signaling axis for potent tumorigenic activity. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is part of a complex that plays a role in maintaining an active pool of phosphatidylinositol 4-kinase (PI4K) at the plasma membrane. This protein is thought to be a peripheral membrane protein that associates with the plasma membrane through palmitoylation. Studies indicate that this gene product plays a role in controlling G protein-coupled receptor (GPCR) activity by affecting receptor phosphorylation. Whole exome sequencing studies have implicated mutations in this gene with autism spectrum disorders. [provided by RefSeq, Apr 2016]., [RefSeq]; These data suggest that mammalian Efr3s contribute to the control of the phosphorylation state and, hence, desensitization of AT1a receptors, and could affect responsiveness of G-protein-coupled receptors in higher eukaryotes., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
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        "predicted_o_glycosites": 1,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
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        "reported_phosphosites": 7,
        "reported_mutagensis": 1,
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        "reported_snv": 20,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A7MD19;Q2VPK2;Q63HL7;Q68DX1;Q6IQ18",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0098793 presynapse",
        "go_biological_process": "GO:0072659 protein localization to plasma membrane;GO:0046854 phosphatidylinositol phosphate biosynthetic process;GO:0016082 synaptic vesicle priming",
        "synthesized_glycan_count": 0,
        "hit_score": 8.5,
        "record_id": "Q14156-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5T890-4",
        "uniprot_id": [
            {
                "id": "ER6L2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5T890",
                "type": "external"
            }
        ],
        "mass": 177127.0,
        "length": 1561,
        "protein_name": "DNA excision repair protein ERCC-6-like 2",
        "gene_name": "ERCC6L2",
        "organism": "Human",
        "refseq_name": "DNA excision repair protein ERCC-6-like 2 isoform c",
        "refseq_ac": [
            {
                "id": "NP_001010895",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001010895",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ERCC6L2; C9orf102; RAD26L",
        "gene_names_refseq": "BMFS2; C9orf102; ERCC6L2; HEBO; RAD26L; SR278",
        "protein_names_uniprotkb": "DNA excision repair protein ERCC-6-like 2; 3.6.4.-; DNA repair and recombination protein RAD26-like; Excision repair cross-complementation group 6-like 2",
        "protein_names_refseq": "DNA excision repair protein ERCC-6-like 2 isoform c; DNA excision repair protein ERCC-6-like 2; DNA repair and recombination protein RAD26-like; excision repair cross-complementation group 6 like 2; excision repair cross-complementing rodent repair deficiency, complementation group 6-like 2; putative repair and recombination helicase RAD26L; stretch responsive protein 278",
        "tax_id": 9606,
        "disease": "pancytopenia-developmental delay syndrome (MONDO:MONDO:0014317)",
        "pathway": " (hsa:375748)",
        "pathway_count": 1,
        "publication_count": 14,
        "publication_id_list": "18669648;20873783;24507776;27185855;28815563;29633571;30379171;32355287;32846126;33960642;36156210;36790458;37014751;37217939",
        "class_list": "",
        "function": "ERCC6L2 mitigates replication stress and promotes centromere stability., [RefSeq, PubMed]; ERCC6L2-associated disorder has recently been described. We identified an additional case through whole-exome sequencing. At the age of 9 years, the patient underwent whole exome sequencing and was discovered to have a homozygous stop mutation in ERCC6L2 (NCBI RefSeq NG_034107.1), c.1687C>T (p.Arg563*). Review article, [RefSeq, PubMed]; ERCC6L2-related disease: a novel entity of bone marrow failure disorder with high risk of clonal evolution. Review article, [RefSeq, PubMed]; Functional Radiogenetic Profiling Implicates ERCC6L2 in Non-homologous End Joining., [RefSeq, PubMed]; Germline ERCC excision repair 6 like 2 (ERCC6L2) mutations lead to impaired erythropoiesis and reshaping of the bone marrow microenvironment., [RefSeq, PubMed]; Hebo is ubiquitously expressed, localized in the nucleus, and rapidly recruited to DNAdsb's in an NBS1-dependent manner., [RefSeq, PubMed]; Microdeletion of 9q22.3: A patient with minimal deletion size associated with a severe phenotype., [RefSeq, PubMed]; Promotes double-strand break (DSB) end-joining and facilitates programmed recombination by controlling how DNA ends are joined in a spatially oriented manner during repair (By similarity). Also plays a role in DNA repair by restricting DNA end resection in double strand break (DSB) repair (PubMed:24507776, PubMed:37014751). Facilitates replication of complex DNA regions and regulates the maintenance of chromatin structure (PubMed:37014751)., [UniProtKB, UniProtKB, PubMed, PubMed]; These observations identify a distinct bone-marrow-failure syndrome due to mutations in ERCC6L2, a gene implicated in DNA repair and mitochondrial function., [RefSeq, PubMed]; This gene encodes a member of the Snf2 family of helicase-like proteins. The encoded protein may play a role in DNA repair and mitochondrial function. Mutations in this gene have been associated with bone marrow failure syndrome 2. Alternatively spliced transcript variants that encode different protein isoforms have been described. [provided by RefSeq, Apr 2014]., [RefSeq]; We report 2 cases of bone marrow failure with no extra-hematopoietic manifestations in patients from unrelated families with a homozygous truncating mutation in ERCC6L2. Bone marrow failure without developmental delay or microcephaly with ERCC6L2 mutation has not been previously described., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A590UJ07;A4D997;B2RTP8;Q49AM9;Q5T892;Q8N663;Q8N9D0;Q9NPM7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0005524 ATP binding;GO:0016787 hydrolase activity;GO:0019901 protein kinase binding;GO:0004386 helicase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005739 mitochondrion;GO:0005813 centrosome",
        "go_biological_process": "GO:0097680 double-strand break repair via classical nonhomologous end joining;GO:0006974 DNA damage response;GO:0034614 cellular response to reactive oxygen species;GO:0036297 interstrand cross-link repair",
        "synthesized_glycan_count": 0,
        "hit_score": 1.7,
        "record_id": "Q5T890-4",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14576-1",
        "uniprot_id": [
            {
                "id": "ELAV3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14576",
                "type": "external"
            }
        ],
        "mass": 39547.0,
        "length": 367,
        "protein_name": "ELAV-like protein 3",
        "gene_name": "ELAVL3",
        "organism": "Human",
        "refseq_name": "ELAV-like protein 3 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001411",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001411",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ELAVL3; HUC; PLE21",
        "gene_names_refseq": "ELAVL3; HUCL; HUC; PLE21",
        "protein_names_uniprotkb": "ELAV-like protein 3; Hu-antigen C; HuC; Paraneoplastic cerebellar degeneration-associated antigen; Paraneoplastic limbic encephalitis antigen 21",
        "protein_names_refseq": "ELAV (embryonic lethal, abnormal vision, Drosophila)-like 3 (Hu antigen C); ELAV like neuron-specific RNA binding protein 3; ELAV-like protein 3 isoform 1; ELAV-like protein 3; Hu antigen C; hu-antigen C; paraneoplastic cerebellar degeneration-associated antigen; paraneoplastic limbic encephalitis antigen 21",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:1995)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "10710437;11237011;25418920;31844290;33592498;34031238;34618203;7511893",
        "class_list": "",
        "function": "A member of the ELAVL protein family, ELAV-like 3 is a neural-specific RNA-binding protein which contains three RNP-type RNA recognition motifs. The observation that ELAVL3 is one of several Hu antigens (neuronal-specific RNA-binding proteins) recognized by the anti-Hu serum antibody present in sera from patients with paraneoplastic encephalomyelitis and sensory neuronopathy (PEM/PSN) suggests it has a role in neurogenesis. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]., [RefSeq]; MiR-124 synergism with ELAVL3 enhances target gene expression to promote neuronal maturity., [RefSeq, PubMed]; Nuclear depletion of RNA-binding protein ELAVL3 (HuC) in sporadic and familial amyotrophic lateral sclerosis., [RefSeq, PubMed]; RNA-binding protein that binds to AU-rich element (ARE) sequences of target mRNAs, including VEGF mRNA (PubMed:10710437). May also bind poly-A tracts via RRM 3 (By similarity). May be involved in neuronal differentiation and maintenance (By similarity). Plays a role in the stabilization of GAP43 mRNA and in spatial learning (By similarity)., [UniProtKB, PubMed, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q16135;Q96CL8;Q96QS9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0035925 mRNA 3'-UTR AU-rich region binding;GO:0140517 protein-RNA adaptor activity;GO:0003723 RNA binding",
        "go_cellular_component": "GO:1990904 ribonucleoprotein complex",
        "go_biological_process": "GO:0007399 nervous system development;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q14576-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q00597-1",
        "uniprot_id": [
            {
                "id": "FANCC_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q00597",
                "type": "external"
            }
        ],
        "mass": 63429.0,
        "length": 558,
        "protein_name": "Fanconi anemia group C protein",
        "gene_name": "FANCC",
        "organism": "Human",
        "refseq_name": "Fanconi anemia group C protein isoform a",
        "refseq_ac": [
            {
                "id": "NP_000127",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000127",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FANCC; FACC; FAC",
        "gene_names_refseq": "FA3; FACC; FAC; FANCC",
        "protein_names_uniprotkb": "Fanconi anemia group C protein; Protein FACC",
        "protein_names_refseq": "Fanconi anemia complementation group C; Fanconi anemia group C protein isoform a; Fanconi anemia group C protein",
        "tax_id": 9606,
        "disease": "tongue squamous cell carcinoma (Disease Ontology:DOID:0050865); aspirin-induced respiratory disease (Disease Ontology:DOID:0080822); Fanconi anemia complementation group C (Disease Ontology:DOID:0111087); pancytopenia (Disease Ontology:DOID:12450); Fanconi anemia (Disease Ontology:DOID:13636); breast cancer (Disease Ontology:DOID:1612); pancreatic cancer (Disease Ontology:DOID:1793); acute myeloid leukemia (Disease Ontology:DOID:9119)",
        "pathway": " (hsa:2176);  (R-HSA-6783310);  (R-HSA-6796648);  (R-HSA-9833482)",
        "pathway_count": 4,
        "publication_count": 247,
        "publication_id_list": "10082513;10348343;10400669;10572087;10620360;10626894;10648614;10848580;10866685;10984493;11096080;11134010;11152499;11156368;11237011;11238103;11238927;11239454;11278865;11313968;11337501;11350938;11350971;11438540;11500375;11520787;11781817;11909525;11939789;11971958;11985496;11988847;12231563;12397061;12670332;12724401;12882984;1373135;14585331;15229216;15299030;15502827;15572677;15737233;1574115;15752359;15781865;15907845;16116422;16179258;16179259;16373505;16431927;16600570;16717090;16916645;16943440;1695551;16982605;17079286;17196820;17289582;17412408;17460694;17938197;18082604;18096616;18174376;18835251;18931676;18957415;19111657;19229320;19416861;19561358;19589784;19596236;19710021;19733181;19804757;19838063;19995904;20102227;20347428;20347429;20385554;20395957;20519500;20603015;20603016;20603073;20670894;20671156;20685959;21072047;21123651;21294215;21464321;21518807;21636578;21701511;21764741;21937648;21978664;21994559;22012619;22214662;22258451;22266823;22287633;22396592;2247437;22510687;22692201;22986343;22988298;23084476;23229543;23325218;23481700;23698467;23723247;23732991;24076221;24347309;24389026;24554720;24623135;24623813;24659800;24662513;24726325;24753571;24905007;25418920;25429106;25430771;25500724;25561469;25576301;25653431;25712099;25848059;25892735;26432638;26446704;26488609;26716879;26817845;26992070;27208315;27269119;27423063;27600516;27920218;27974558;28069888;28167698;28228285;28281686;28514659;28765891;28832583;28834231;28904123;29170442;29175459;29231267;29242379;29348664;29393594;29394925;29395325;29440070;29501855;29557506;29769354;30174290;30315122;30379171;30484775;30770398;31031002;31092671;31217245;31844290;31848261;32093270;32161166;32265295;32387766;32488085;32502341;32716602;32801355;32938616;32983136;33141586;33298915;33592498;33808629;33911136;33960642;33968037;34171305;34174402;34864095;34932366;34974812;35051231;35685460;35947956;36010968;36215666;36241641;36712380;37127961;7491766;7515177;7517562;7545299;7565688;7693978;7737357;7903669;8058745;8128956;8348157;8490620;8499901;8576172;8576179;8661426;8810342;8844212;8910500;9034343;9063748;9079663;9242535;9442054;9521856;9528799;9687506;9737981;9819388;9920933",
        "class_list": "",
        "function": "DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1., [UniProtKB, UniProtKB, UniProtKB, PubMed]; In silico study of missense variants of FANCA, FANCC and FANCG genes reveals high risk deleterious alleles predisposing to Fanconi anemia pathogenesis., [RefSeq, PubMed]; Microdeletion of 9q22.3: A patient with minimal deletion size associated with a severe phenotype., [RefSeq, PubMed]; The Fanconi anemia complementation group (FANC) currently includes FANCA, FANCB, FANCC, FANCD1 (also called BRCA2), FANCD2, FANCE, FANCF, FANCG, FANCI, FANCJ (also called BRIP1), FANCL, FANCM and FANCN (also called PALB2). The previously defined group FANCH is the same as FANCA. Fanconi anemia is a genetically heterogeneous recessive disorder characterized by cytogenetic instability, hypersensitivity to DNA crosslinking agents, increased chromosomal breakage, and defective DNA repair. The members of the Fanconi anemia complementation group do not share sequence similarity; they are related by their assembly into a common nuclear protein complex. This gene encodes the protein for complementation group C. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
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        "reported_snv": 12,
        "reported_interactions": 0,
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        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 8,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B1ALR8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0043240 Fanconi anaemia nuclear complex;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006281 DNA repair;GO:0034599 cellular response to oxidative stress;GO:0036297 interstrand cross-link repair;GO:0006289 nucleotide-excision repair;GO:0065003 protein-containing complex assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 25.0,
        "record_id": "Q00597-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q4G163-1",
        "uniprot_id": [
            {
                "id": "FBX43_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q4G163",
                "type": "external"
            }
        ],
        "mass": 78402.0,
        "length": 708,
        "protein_name": "F-box only protein 43",
        "gene_name": "FBXO43",
        "organism": "Human",
        "refseq_name": "F-box only protein 43",
        "refseq_ac": [
            {
                "id": "NP_001025031",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001025031",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FBXO43; EMI2",
        "gene_names_refseq": "EMI2; ERP1; FBX43; FBXO43; OOMD12; OZEMA12; SPGF64",
        "protein_names_uniprotkb": "F-box only protein 43; Endogenous meiotic inhibitor 2",
        "protein_names_refseq": "F-box only protein 43; early mitotic inhibitor 2; endogenous meiotic inhibitor 2",
        "tax_id": 9606,
        "disease": "spermatogenic failure 64 (Disease Ontology:DOID:0112353); oocyte maturation defect 12 (MONDO:MONDO:0030523)",
        "pathway": " (hsa:286151)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;15520277;15753281;16407128;18550795;26992070;28834231;28904123;29237092;29557506;30878252;31844290;32157095;34052850;34595750;34645483;36710413;37250703;38604312",
        "class_list": "",
        "function": "A homozygous loss-of-function mutation in FBXO43 causes human non-obstructive azoospermia., [RefSeq, PubMed]; Association between F-box-only protein 43 overexpression and hepatocellular carcinoma pathogenesis and prognosis., [RefSeq, PubMed]; Cdc2 and Mos regulate Emi2 stability to promote the meiosis I-meiosis II transition, [RefSeq, PubMed]; Clinical significance of FBXO43 in hepatocellular carcinoma and its impact on tumor cell proliferation, migration and invasion. Publication Status: Online-Only, [RefSeq, PubMed]; Downregulation of the FBXO43 gene inhibits tumor growth in human breast cancer by limiting its interaction with PCNA. Publication Status: Online-Only, [RefSeq, PubMed]; FBXO43 promotes cell cycle progression in cancer cells through stabilizing SKP2., [RefSeq, PubMed]; Members of the F-box protein family, such as FBXO43, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]., [RefSeq]; Required to establish and maintain the arrest of oocytes at the second meiotic metaphase until fertilization. Acts by inhibiting the anaphase-promoting complex/cyclosome (APC/C) ubiquitin ligase. Probably recognizes and binds to some phosphorylated proteins and promotes their ubiquitination and degradation (PubMed:34052850, PubMed:34595750). Plays a vital role in modulating the ubiquitilation of CCNB1 and CDK1 during gametogenesis., [UniProtKB, PubMed, UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
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        "total_o_glycosites": 1,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0010948 negative regulation of cell cycle process;GO:1990090 cellular response to nerve growth factor stimulus;GO:0016567 protein ubiquitination;GO:0007088 regulation of mitotic nuclear division;GO:0051321 meiotic cell cycle",
        "synthesized_glycan_count": 0,
        "hit_score": 2.2,
        "record_id": "Q4G163-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UKG4-1",
        "uniprot_id": [
            {
                "id": "S13A4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UKG4",
                "type": "external"
            }
        ],
        "mass": 69358.0,
        "length": 626,
        "protein_name": "Solute carrier family 13 member 4",
        "gene_name": "SLC13A4",
        "organism": "Human",
        "refseq_name": "solute carrier family 13 member 4 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001305121",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001305121",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "SLC13A4; SUT1",
        "gene_names_refseq": "NAS2; SLC13A4; SUT-1; SUT1",
        "protein_names_uniprotkb": "Solute carrier family 13 member 4; Na(+)/sulfate cotransporter SUT-1; NaS2",
        "protein_names_refseq": "Na(+)/sulfate cotransporter SUT-1; solute carrier family 13 (sodium/sulfate symporter), member 4; solute carrier family 13 (sodium/sulfate symporters), member 4; solute carrier family 13 (sodium/sulphate symporters), member 4; solute carrier family 13 member 4 isoform 1; sulphate transporter 1",
        "tax_id": 9606,
        "disease": "alcohol-related neurodevelopmental disorder (Disease Ontology:DOID:0050667); Kohlschutter-Tonz syndrome (Disease Ontology:DOID:0111668); epilepsy (Disease Ontology:DOID:1826)",
        "pathway": " (hsa:26266);  (R-HSA-433137)",
        "pathway_count": 2,
        "publication_count": 13,
        "publication_id_list": "10535998;11161786;11237011;15607730;23453247;23485456;24715725;28385533;31844290;32387766;34840533;35051231;35318648",
        "class_list": "",
        "function": "Here, we characterized the functional properties of the human Na(+)-sulfate cotransporter (hNaS2), determined its tissue distribution, and identified its gene (SLC13A4) structure., [RefSeq, PubMed]; SLC13A4 Might Serve as a Prognostic Biomarker and be Correlated with Immune Infiltration into Head and Neck Squamous Cell Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; SLC13A4 and SLC26A2 were the most abundant sulfate transporter mRNAs, which localized to syncytiotrophoblast and cytotrophoblast cells, respectively., [RefSeq, PubMed]; Sodium:sulfate symporter that mediates sulfate reabsorption in the high endothelial venules (HEV)., [UniProtKB, PubMed, PubMed]; Study found that despite differential expression of the two SLC13A4 transcripts, no detectable functional difference in the cellular sorting or sulfate transporting was found. However, some variants can influence both mechanism in specific cell membranes. This is like to have clinical implications based on the consequences of impaired sulfate transport during pregnancy in rodent models., [RefSeq, PubMed]; To investigate the regulation of SLC13A4 gene expression, we analysed the transcriptional activity of the SLC13A4 5'-flanking region in the JEG-3 placental cell line using luciferase reporter assays., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A4D1Q4;Q8N631",
        "ec_number_list": [],
        "go_molecular_function": "GO:0015382 sodium:sulfate symporter activity;GO:0022857 transmembrane transporter activity;GO:0015370 solute:sodium symporter activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0055085 transmembrane transport;GO:1902358 sulfate transmembrane transport",
        "synthesized_glycan_count": 0,
        "hit_score": 1.4,
        "record_id": "Q9UKG4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q12926-1",
        "uniprot_id": [
            {
                "id": "ELAV2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q12926",
                "type": "external"
            }
        ],
        "mass": 39504.0,
        "length": 359,
        "protein_name": "ELAV-like protein 2",
        "gene_name": "ELAVL2",
        "organism": "Human",
        "refseq_name": "ELAV-like protein 2 isoform b",
        "refseq_ac": [
            {
                "id": "NP_001164666",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001164666",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ELAVL2; HUB",
        "gene_names_refseq": "ELAVL2; HEL-N1; HELN1; HUB",
        "protein_names_uniprotkb": "ELAV-like protein 2; ELAV-like neuronal protein 1; Hu-antigen B; HuB; Nervous system-specific RNA-binding protein Hel-N1",
        "protein_names_refseq": "ELAV (embryonic lethal, abnormal vision, Drosophila)-like 2 (Hu antigen B); ELAV like neuron-specific RNA binding protein 2; ELAV-like protein 2 isoform b; ELAV-like protein 2; hu-antigen B; nervous system-specific RNA-binding protein Hel-N1",
        "tax_id": 9606,
        "disease": "myoglobinuria (Disease Ontology:DOID:0080108)",
        "pathway": " (hsa:1993);  (R-HSA-9918481)",
        "pathway_count": 2,
        "publication_count": 28,
        "publication_id_list": "11237011;11747608;14519844;14762106;15084397;17289661;18669648;19413330;20068231;21911577;23301498;26092250;27108190;29557506;29902443;30599162;32938616;33177556;34019948;34946837;35215846;36010968;36032660;36877306;37773661;37938771;7972035;8158249",
        "class_list": "",
        "function": "Analysis of Enrichment Pathway, Hub Gene, and Protein-Protein Interaction Network in Rheumatoid Arthritis and Construction of Molecular Subtypes in Peripheral Blood., [RefSeq, PubMed]; Bioinformatic Analysis Identified Hub Genes Associated with Heterocyclic Amines Induced Cytotoxicity of Peripheral Blood Mononuclear Cells. Publication Status: Online-Only, [RefSeq, PubMed]; Identification of Hub Genes Associated with Resistance to Prednisolone in Acute Lymphoblastic Leukemia Based on Weighted Gene Co-expression Network Analysis., [RefSeq, PubMed]; Identification of Hub Genes of Lung Adenocarcinoma Based on Weighted Gene Co-Expression Network in Chinese Population. Publication Status: Online-Only, [RefSeq, PubMed]; In humans, the ELAV like RNA binding protein gene family has four members (ELAVL1-4). ELAVL RNA binding proteins recognize AU-rich elements in the 3' UTRs of gene transcripts and thereby regulate gene expression post-transcriptionally. The protein encoded by this gene binds to several 3' UTRs, including its own and also that of FOS, ID, and POU5F1. This gene encodes ELAVL2 and, like ELAVL3 and ELAVL4, is expressed specifically in neurons and primarily localizes to the cytoplasm. This protein also forms a cytosolic complex with the normally nuclear-localized ELAVL1 protein. Alternative splicing of this gene results in multiple transcript variants encoding distinct protein isoforms. [provided by RefSeq, Jul 2020]., [RefSeq]; RNA-binding protein that binds to the 3' untranslated region (3'UTR) of target mRNAs (By similarity). Seems to recognize a GAAA motif (By similarity). Can bind to its own 3'UTR, the FOS 3'UTR and the ID 3'UTR (By similarity)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DRK3;Q13235;Q59G15;Q8NEM4;Q9H1Q8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003730 mRNA 3'-UTR binding;GO:0140517 protein-RNA adaptor activity",
        "go_cellular_component": "GO:1990904 ribonucleoprotein complex;GO:0005634 nucleus",
        "go_biological_process": "GO:0006355 regulation of DNA-templated transcription;GO:0050686 negative regulation of mRNA processing",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "Q12926-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P00488-1",
        "uniprot_id": [
            {
                "id": "F13A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P00488",
                "type": "external"
            }
        ],
        "mass": 83268.0,
        "length": 732,
        "protein_name": "Coagulation factor XIII A chain",
        "gene_name": "F13A1",
        "organism": "Human",
        "refseq_name": "coagulation factor XIII A chain",
        "refseq_ac": [
            {
                "id": "NP_000120",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000120",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "F13A1; F13A",
        "gene_names_refseq": "F13A1; F13A",
        "protein_names_uniprotkb": "Coagulation factor XIII A chain; 2.3.2.13; Coagulation factor XIIIa; Protein-glutamine gamma-glutamyltransferase A chain; Transglutaminase A chain",
        "protein_names_refseq": "FSF, A subunit; TGase; bA525O21.1 (coagulation factor XIII, A1 polypeptide); coagulation factor XIII A chain; coagulation factor XIII, A polypeptide; coagulation factor XIIIa; factor XIIIa; fibrin stabilizing factor, A subunit; fibrinoligase; protein-glutamine gamma-glutamyltransferase A chain; transglutaminase A chain; transglutaminase. plasma",
        "tax_id": 9606,
        "disease": "cardiomyopathy (Disease Ontology:DOID:0050700); colorectal adenoma (Disease Ontology:DOID:0050860); colorectal adenocarcinoma (Disease Ontology:DOID:0050861); stroke (Disease Ontology:DOID:0051061); Noonan syndrome 5 (Disease Ontology:DOID:0060583); Noonan syndrome with multiple lentigines 2 (Disease Ontology:DOID:0080549); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); dilated cardiomyopathy 1NN (Disease Ontology:DOID:0110432); thrombophilia due to thrombin defect (Disease Ontology:DOID:0111907); prostate cancer (Disease Ontology:DOID:10283); gastric ulcer (Disease Ontology:DOID:10808); disseminated intravascular coagulation (Disease Ontology:DOID:11247); cancer (Disease Ontology:DOID:162); factor XIII deficiency (Disease Ontology:DOID:2211); arteriosclerosis (Disease Ontology:DOID:2349); prostate adenocarcinoma (Disease Ontology:DOID:2526); high grade glioma (Disease Ontology:DOID:3070); Noonan syndrome (Disease Ontology:DOID:3490); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); pancreatic carcinoma (Disease Ontology:DOID:4905); myocardial infarction (Disease Ontology:DOID:5844); Crohn's disease (Disease Ontology:DOID:8778); diabetic retinopathy (Disease Ontology:DOID:8947); priapism (Disease Ontology:DOID:9286); pulmonary embolism (Disease Ontology:DOID:9477)",
        "pathway": " (hsa:2162);  (R-HSA-114608);  (R-HSA-6785807);  (R-HSA-9769733)",
        "pathway_count": 4,
        "publication_count": 151,
        "publication_id_list": "10.1101/2023.09.13.557529;10023775;10219247;10369418;10391209;10510379;10586089;10867011;11058569;11084045;11104795;11120780;11237011;11278437;11278729;11356008;11380452;11404481;11463377;11960372;12223527;12242343;12600988;12832402;1353995;1435334;14630798;14634100;14712222;15116091;15261459;15297306;15584925;15805299;15869882;15950906;16007214;16048438;16107692;16205632;16236134;16335952;16397018;16451196;16510571;16540365;16606674;17427945;17458857;17572495;18243101;18353781;18447642;18644974;19124156;19185846;19397496;20179087;20493732;21081667;21102457;21252155;21689689;21730069;21742792;21937440;21994466;22046235;22205702;22383755;22693070;22851691;23086340;23124025;23172665;23455323;23481700;23555662;23640497;23783831;23967200;24097101;24286209;24329762;24743777;24889649;25234944;25892735;26247044;26375851;26728094;27363989;2742826;28228285;2866798;2877456;2877457;28832583;2901091;29242379;29508533;29632711;29769354;29786170;29789417;3026437;30315122;31848261;33043033;34185709;36215666;36284347;36987725;37180121;37217939;37314674;37883802;37938771;38246706;4405643;4811064;6457647;7356959;7510216;7512451;7513094;7529288;7660355;7795521;7796300;7898939;7907877;7913750;7913909;8085155;8467233;8602263;8621622;8663118;8668165;8797861;8816495;9013879;9515726;9651359;9723655;9736340;9763561;9822675;9874564;9988734",
        "class_list": "",
        "function": "Clinical Profile of Congenital Factor XIII Deficiency in Children., [RefSeq, PubMed]; Factor XIII is activated by thrombin and calcium ion to a transglutaminase that catalyzes the formation of gamma-glutamyl-epsilon-lysine cross-links between fibrin chains, thus stabilizing the fibrin clot. Also cross-link alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin., [UniProtKB, PubMed]; Linking inflammation and angiogenesis with fibrogenesis: Expression of FXIIIA, MMP-9, and VEGF in oral submucous fibrosis., [RefSeq, PubMed]; Macrophages-derived Factor XIII links coagulation to inflammation in COPD. Publication Status: Online-Only, [RefSeq, PubMed]; Reciprocal stabilization of coagulation factor XIII-A and -B subunits is a determinant of plasma FXIII concentration., [RefSeq, PubMed]; This gene encodes the coagulation factor XIII A subunit. Coagulation factor XIII is the last zymogen to become activated in the blood coagulation cascade. Plasma factor XIII is a heterotetramer composed of 2 A subunits and 2 B subunits. The A subunits have catalytic function, and the B subunits do not have enzymatic activity and may serve as plasma carrier molecules. Platelet factor XIII is comprised only of 2 A subunits, which are identical to those of plasma origin. Upon cleavage of the activation peptide by thrombin and in the presence of calcium ion, the plasma factor XIII dissociates its B subunits and yields the same active enzyme, factor XIIIa, as platelet factor XIII. This enzyme acts as a transglutaminase to catalyze the formation of gamma-glutamyl-epsilon-lysine crosslinking between fibrin molecules, thus stabilizing the fibrin clot. It also crosslinks alpha-2-plasmin inhibitor, or fibronectin, to the alpha chains of fibrin. Factor XIII deficiency is classified into two categories: type I deficiency, characterized by the lack of both the A and B subunits; and type II deficiency, characterized by the lack of the A subunit alone. These defects can result in a lifelong bleeding tendency, defective wound healing, and habitual abortion. [provided by RefSeq, Jul 2008]., [RefSeq]; [Gene diagnosis of a family with coagulation factor deficiency caused by large deletion of F13A1 gene]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 35,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 25,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q59HA7;Q8N6X2;Q96P24;Q9BX29",
        "ec_number_list": [
            {
                "id": "1.8.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.2",
                "type": "external"
            },
            {
                "id": "2.3.2.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.13",
                "type": "external"
            },
            {
                "id": "3.4.21.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.5",
                "type": "external"
            },
            {
                "id": "3.4.21.46",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.46",
                "type": "external"
            },
            {
                "id": "3.4.21.69",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.69",
                "type": "external"
            },
            {
                "id": "4.1.2.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.2.13",
                "type": "external"
            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "3.5.1.44",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.5.1.44",
                "type": "external"
            },
            {
                "id": "1.8.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.8.3.5",
                "type": "external"
            },
            {
                "id": "1.-.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.-.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0003810 protein-glutamine gamma-glutamyltransferase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0031093 platelet alpha granule lumen;GO:0072562 blood microparticle",
        "go_biological_process": "GO:0007596 blood coagulation;GO:0018149 peptide cross-linking;GO:0072378 blood coagulation, fibrin clot formation",
        "synthesized_glycan_count": 0,
        "hit_score": 15.9,
        "record_id": "P00488-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P55199-1",
        "uniprot_id": [
            {
                "id": "ELL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P55199",
                "type": "external"
            }
        ],
        "mass": 68265.0,
        "length": 621,
        "protein_name": "RNA polymerase II elongation factor ELL",
        "gene_name": "ELL",
        "organism": "Human",
        "refseq_name": "RNA polymerase II elongation factor ELL",
        "refseq_ac": [
            {
                "id": "NP_006523",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006523",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ELL; C19orf17",
        "gene_names_refseq": "C19orf17; ELL1; ELL; MEN; PPP1R68",
        "protein_names_uniprotkb": "RNA polymerase II elongation factor ELL; Eleven-nineteen lysine-rich leukemia protein",
        "protein_names_refseq": "ELL gene (11-19 lysine-rich leukemia gene); ELL/KMT2A fusion protein; KMT2A/ELL fusion protein; RNA polymerase II elongation factor ELL; eleven-nineteen lysine-rich leukemia protein; elongation factor RNA polymerase II; protein phosphatase 1, regulatory subunit 68",
        "tax_id": 9606,
        "disease": "cancer (Disease Ontology:DOID:162)",
        "pathway": " (hsa:8178);  (R-HSA-112382);  (R-HSA-167152);  (R-HSA-167200);  (R-HSA-167238);  (R-HSA-167243);  (R-HSA-167246);  (R-HSA-167287);  (R-HSA-167290);  (R-HSA-674695);  (R-HSA-6781827);  (R-HSA-6796648);  (R-HSA-6807505);  (R-HSA-75955)",
        "pathway_count": 14,
        "publication_count": 168,
        "publication_id_list": "10.1101/2023.09.13.557529;10022900;10199401;10757782;10866664;10984493;11237011;11313498;11313499;11350971;11418481;11856838;11859374;11884399;11971958;11988847;12414730;12446457;12574128;12676794;12686606;14701750;14701755;1535687;15489290;15781865;16006523;16239144;16308568;16751180;16901896;17081983;17234882;1739980;17525332;17924679;18077418;18079403;1829677;18669648;1939271;19664995;19667075;19952111;20068231;20159561;20457598;20471948;20541997;2125285;22012619;22137580;22195968;22231121;22252320;22252557;22441827;22466610;22466611;22466612;22895430;22902626;22988298;23166507;23186163;23538671;23906714;23932780;23973375;24097444;24127601;24270878;24413172;2449431;24554720;24662513;24715725;24997600;25429106;25561469;25576301;25675981;25712099;25880248;26154972;26659056;26811146;26992070;27268141;27600516;27846572;27862975;27920218;28063628;28218747;28228285;28832583;28834231;28904123;29242379;29331515;29393594;29437277;2944599;29493099;29508533;29557506;29632046;29632711;29786170;29789417;30315122;31217245;31844290;32152128;32157095;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33141586;33157094;33298915;33392160;33592498;33691108;33912179;33936100;33968037;33981976;34087483;34509645;34561969;34932366;35051231;35318648;35580925;36010968;36241641;36284347;36305813;36543308;37938771;40914422;7660122;7660129;7660130;7715707;7853496;7991593;8253082;8339931;8370526;8596958;8628262;8668525;9009278;9063748;9153304;9188510;9407024;9450929;9489704;9705341;9832505",
        "class_list": "",
        "function": "ATM-mediated ELL phosphorylation enhances its self-association through increased EAF1 interaction and inhibits global transcription during genotoxic stress. Erratum:[Nucleic Acids Res. 2023 Jul 7;51(12):6507. doi: 10.1093/nar/gkad454. PMID: 37194690], [RefSeq, PubMed]; E1A-associated p300 protein -mediated site-specific acetylation increases, whereas histone deacetylase 3-mediated deacetylation decreases, transcriptional elongation factor ELL stability through polyubiquitylation by the E3 ubiquitin ligase Siah1. Knockdown of human cell cycle and apoptosis regulator 2 reduces ELL levels and expression of a significant number of genes, including those involved in glucose metabolism., [RefSeq, PubMed]; ELL Facilitates RNA Polymerase II-Mediated Transcription of Human Epidermal Proliferation Genes., [RefSeq, PubMed]; Elongation factor component of the super elongation complex (SEC), a complex required to increase the catalytic rate of RNA polymerase II transcription by suppressing transient pausing by the polymerase at multiple sites along the DNA. Elongation factor component of the little elongation complex (LEC), a complex required to regulate small nuclear RNA (snRNA) gene transcription by RNA polymerase II and III (PubMed:22195968, PubMed:23932780). Specifically required for stimulating the elongation step of RNA polymerase II- and III-dependent snRNA gene transcription (PubMed:23932780). ELL also plays an early role before its assembly into in the SEC complex by stabilizing RNA polymerase II recruitment/initiation and entry into the pause site. Required to stabilize the pre-initiation complex and early elongation., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Stratification and therapeutic potential of ELL in cytogenetic normal acute myeloid leukemia., [RefSeq, PubMed]; The results indicate that p53 interferes with the interaction between ELL/EAF and ICE1 and represses transcription of small nuclear RNA genes by Pol II., [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
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        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 10,
        "reported_mutagensis": 0,
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        "reported_snv": 17,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:0019902 phosphatase binding",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0008023 transcription elongation factor complex;GO:0016607 nuclear speck;GO:0016604 nuclear body;GO:0015030 Cajal body",
        "go_biological_process": "GO:1905382 positive regulation of snRNA transcription by RNA polymerase II;GO:0045945 positive regulation of transcription by RNA polymerase III;GO:0006368 transcription elongation by RNA polymerase II;GO:0032968 positive regulation of transcription elongation by RNA polymerase II;GO:0042795 snRNA transcription by RNA polymerase II",
        "synthesized_glycan_count": 0,
        "hit_score": 17.3,
        "record_id": "P55199-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q01664-1",
        "uniprot_id": [
            {
                "id": "TFAP4_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q01664",
                "type": "external"
            }
        ],
        "mass": 38726.0,
        "length": 338,
        "protein_name": "Transcription factor AP-4",
        "gene_name": "TFAP4",
        "organism": "Human",
        "refseq_name": "transcription factor AP-4",
        "refseq_ac": [
            {
                "id": "NP_003214",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003214",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TFAP4; BHLHC41",
        "gene_names_refseq": "AP-4; TFAP4; bHLHc41",
        "protein_names_uniprotkb": "Transcription factor AP-4; Activating enhancer-binding protein 4; Class C basic helix-loop-helix protein 41; bHLHc41",
        "protein_names_refseq": "activating enhancer-binding protein 4; class C basic helix-loop-helix protein 41; transcription factor AP-4 (activating enhancer binding protein 4); transcription factor AP-4",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:7023)",
        "pathway_count": 1,
        "publication_count": 56,
        "publication_id_list": "11237011;17081983;17287340;17322306;18212344;18452278;18669648;19415658;19651622;19664994;19664995;20068231;2123466;21406692;23186163;23301498;24366607;24715725;25576301;26992070;27846572;28832583;28904123;29242379;29393594;29485866;29632046;30379171;31844290;32157095;32387766;32574038;33141586;33214551;33298915;33592498;33691108;33968037;33981976;34019948;34087483;34171305;34509645;34932366;35001801;35318648;35777810;36010968;36074102;36215666;36241641;36894688;37610449;39534244;40596516;7933101",
        "class_list": "",
        "function": "Deletion of the transcriptional regulator TFAP4 accelerates c-MYC-driven lymphomagenesis., [RefSeq, PubMed]; Downregulation of miR-144 blocked the proliferation and invasion of nerve cells in Hirschsprung disease by regulating Transcription Factor AP 4 (TFAP4). Publication Status: Online-Only, [RefSeq, PubMed]; Inhibitory effect of CC chemokine ligand 23 (CCL23)/ transcription factor activating enhancer binding protein 4 (TFAP4) on cell proliferation, invasion and angiogenesis in hepatocellular carcinoma., [RefSeq, PubMed]; TFAP4 Activates IGF2BP1 and Promotes Progression of Non-Small Cell Lung Cancer by Stabilizing TK1 Expression through m6A Modification., [RefSeq, PubMed]; Transcription factor that activates both viral and cellular genes by binding to the symmetrical DNA sequence 5'-CAGCTG-3'., [UniProtKB]; Transcription factors of the basic helix-loop-helix-zipper (bHLH-ZIP) family contain a basic domain, which is used for DNA binding, and HLH and ZIP domains, which are used for oligomerization. Transcription factor AP4 activates both viral and cellular genes by binding to the symmetrical DNA sequence CAGCTG (Mermod et al., 1988 [PubMed 2833704]; Hu et al., 1990 [PubMed 2123466]).[supplied by OMIM, Jul 2009]., [RefSeq]; Tribbles Pseudokinase 2 Promotes the Proliferation, Migration, and Invasion of Osteosarcoma through Modulating AP4/p21 Pathway., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 7,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 7,
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        "reported_phosphosites": 7,
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        "reported_snv": 19,
        "reported_interactions": 0,
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        "biomarker_type": "",
        "glycan_count": 1,
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        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60409",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0042803 protein homodimerization activity;GO:0042826 histone deacetylase binding;GO:0000976 transcription cis-regulatory region binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0017053 transcription repressor complex;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0008285 negative regulation of cell population proliferation;GO:0010629 negative regulation of gene expression;GO:0043065 positive regulation of apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "Q01664-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6PCB8-1",
        "uniprot_id": [
            {
                "id": "EMB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6PCB8",
                "type": "external"
            }
        ],
        "mass": 36881.0,
        "length": 327,
        "protein_name": "Embigin",
        "gene_name": "EMB",
        "organism": "Human",
        "refseq_name": "embigin precursor",
        "refseq_ac": [
            {
                "id": "NP_940851",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_940851",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EMB",
        "gene_names_refseq": "EMB; GP70",
        "protein_names_uniprotkb": "Embigin",
        "protein_names_refseq": "embigin homolog; embigin precursor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:133418);  (R-HSA-433692)",
        "pathway_count": 2,
        "publication_count": 56,
        "publication_id_list": "10.1101/2023.09.13.557529;10493836;10590411;11237011;12657613;13929721;15911216;15917240;17701893;18582575;19349973;21787388;24190977;24265240;24397554;24715725;25773908;26090721;26154972;26992070;27862975;28218747;28228285;28832583;29242379;29393594;29557506;29632046;29632711;2963822;29741879;30315122;30446621;31154438;31530632;31844290;31848261;32157095;32161166;32213169;32387766;32488085;32502341;32938616;32983136;33141586;33298915;33392160;33691108;33968037;34357683;34509645;35580925;36284347;8124722;9786900",
        "class_list": "",
        "function": "Data show that Gp70 (embigin) was negative in all normal, adjacent non-neoplastic and PIN lesions and only a very small percentage of cases. Publication Status: Online-Only, [RefSeq, PubMed]; Embigin is regulated by HOXC8 and its loss plays an important role in the progression of breast tumors, [RefSeq, PubMed]; Plays a role in the outgrowth of motoneurons and in the formation of neuromuscular junctions. Following muscle denervation, promotes nerve terminal sprouting and the formation of additional acetylcholine receptor clusters at synaptic sites without affecting terminal Schwann cell number or morphology. Delays the retraction of terminal sprouts following re-innervation of denervated endplates. May play a role in targeting the monocarboxylate transporters SLC16A1, SLC16A6 and SLC16A7 to the cell membrane (By similarity)., [UniProtKB, UniProtKB]; Rare and common variants analysis of the EMB gene in patients with schizophrenia. Publication Status: Online-Only, [RefSeq, PubMed]; Reports the original cloning of the mouse embigin gene, referred to as gp70, from embryonal carcinoma cells., [RefSeq, PubMed]; Study reports elevated expression of Embigin in pancreatic ductal adenocarcinoma and shows its novel functions in regulating cell proliferation, migration, and invasion., [RefSeq, PubMed]; This gene encodes a transmembrane glycoprotein that is a member of the immunoglobulin superfamily. The encoded protein may be involved in cell growth and development by mediating interactions between the cell and extracellular matrix. A pseudogene of this gene is found on chromosome 1. [provided by RefSeq, Jan 2009]., [RefSeq]; This study analyzed the direct interaction between CAIV and the two Monocarboxylate transporters (MCTs) chaperones basigin (CD147) and embigin (GP70)., [RefSeq, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 6,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 6,
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        "reported_snv": 32,
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        "missing_score": 9606,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z6S3;B7Z902",
        "ec_number_list": [],
        "go_molecular_function": "GO:0098632 cell-cell adhesion mediator activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030424 axon;GO:0045202 synapse",
        "go_biological_process": "GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules;GO:0007411 axon guidance;GO:0070593 dendrite self-avoidance;GO:0035879 plasma membrane lactate transport",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q6PCB8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P12319-1",
        "uniprot_id": [
            {
                "id": "FCERA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P12319",
                "type": "external"
            }
        ],
        "mass": 29596.0,
        "length": 257,
        "protein_name": "High affinity immunoglobulin epsilon receptor subunit alpha",
        "gene_name": "FCER1A",
        "organism": "Human",
        "refseq_name": "high affinity immunoglobulin epsilon receptor subunit alpha isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001992",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001992",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FCER1A; FCE1A",
        "gene_names_refseq": "FCE1A; FCER1A; FCERIA; FcERI",
        "protein_names_uniprotkb": "High affinity immunoglobulin epsilon receptor subunit alpha; Fc-epsilon RI-alpha; FcERI; IgE Fc receptor subunit alpha",
        "protein_names_refseq": "Fc IgE receptor, alpha polypeptide; Fc epsilon RI alpha-chain; Fc fragment of IgE receptor Ia; Fc fragment of IgE, high affinity I, receptor for; Fc-epsilon RI-alpha; FcepsilonRI alpha chain; FcepsilonRIalpha; alpha polypeptide; high affinity immunoglobulin epsilon receptor alpha-subunit; high affinity immunoglobulin epsilon receptor subunit alpha isoform 1 precursor; high affinity immunoglobulin epsilon receptor subunit alpha; igE Fc receptor subunit alpha; immunoglobulin E receptor, high-affinity, of mast cells, alpha polypeptide",
        "tax_id": 9606,
        "disease": "asthma (Disease Ontology:DOID:2841); rhinitis (Disease Ontology:DOID:4483)",
        "pathway": " (hsa:2205);  (R-HSA-2454202);  (R-HSA-2730905);  (R-HSA-2871796);  (R-HSA-2871809);  (R-HSA-2871837)",
        "pathway_count": 6,
        "publication_count": 115,
        "publication_id_list": "10026222;10068651;10072481;10395673;10523831;10702308;10838074;10860980;10882101;10917520;10921459;11007481;11015619;11030334;11090634;11237011;11278486;11306453;11325957;11340169;11368773;11395409;11460167;11531339;11713268;11772397;11804587;12217391;12473184;12573241;12660731;12670394;12670955;12975316;14514672;14630197;1472946;15010370;15125833;15327770;15548136;15686303;16186825;16252004;16356853;16356856;16456001;16831874;16938345;16978534;17047224;17135271;17158449;17428801;17496917;17498065;17502104;17540168;17948050;17993265;18296442;18772140;19124833;19574218;19592646;19909365;20300203;20685844;21216468;21653832;21966355;22798961;25200415;27862975;2833705;29557506;2964640;2967464;30429286;31848261;33043033;33123756;33160967;34420484;34925339;35051231;36368013;36430378;7518558;7526393;7528327;7855889;7997270;8071371;8114916;8125119;8493579;8551243;8629002;8630736;8631904;8663278;8673706;8702662;8799126;8910399;8986718;8995445;9099726;9199344;9295361;9477973;9639556;9875849;9989831",
        "class_list": "",
        "function": "Data indicate that although results rather show the lack of an association between FCER1A rs41264475 mutation and atopic dermatitis, they suggest that its minor allele can predispose to the concomitant asthma in AD patients., [RefSeq, PubMed]; FcER1: A Novel Molecule Implicated in the Progression of Human Diabetic Kidney Disease. Publication Status: Online-Only, [RefSeq, PubMed]; Genetic association study of CTLA4 and FCepsilonRIalpha polymorphisms in asthmatic patients in the southwestern region of Iran., [RefSeq, PubMed]; High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions., [UniProtKB, PubMed, PubMed]; Inverse association of FCER1A allergy variant in monocytes and plasmacytoid dendritic cells., [RefSeq, PubMed]; Signals from the TAFA4-PTEN-PU.1 axis alleviate nasal allergy by modulating the expression of FcepsilonRI in mast cells., [RefSeq, PubMed]; The Crosstalk between FcepsilonRI and Sphingosine Signaling in Allergic Inflammation. Review article Publication Status: Online-Only, [RefSeq, PubMed]; The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit. [provided by RefSeq, Aug 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "reported_n_glycosites": 7,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 7,
        "total_reported_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 3,
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        "reported_snv": 29,
        "reported_interactions": 0,
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        "biomarker_type": "",
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        "glyco_site_count": 7,
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019863 IgE binding;GO:0019768 high-affinity IgE receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0016064 immunoglobulin mediated immune response;GO:0042092 type 2 immune response;GO:0043303 mast cell degranulation;GO:0043308 eosinophil degranulation",
        "synthesized_glycan_count": 0,
        "hit_score": 12.6,
        "record_id": "P12319-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000000000.100.00000",
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    {
        "uniprot_canonical_ac": "Q99952-1",
        "uniprot_id": [
            {
                "id": "PTN18_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99952",
                "type": "external"
            }
        ],
        "mass": 50482.0,
        "length": 460,
        "protein_name": "Tyrosine-protein phosphatase non-receptor type 18",
        "gene_name": "PTPN18",
        "organism": "Human",
        "refseq_name": "tyrosine-protein phosphatase non-receptor type 18 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001135842",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001135842",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTPN18; BDP1",
        "gene_names_refseq": "BDP1; PTP-HSCF; PTPN18",
        "protein_names_uniprotkb": "Tyrosine-protein phosphatase non-receptor type 18; 3.1.3.48; Brain-derived phosphatase",
        "protein_names_refseq": "brain-derived phosphatase; protein tyrosine phosphatase, non-receptor type 18 (brain-derived); tyrosine-protein phosphatase non-receptor type 18 isoform 2; tyrosine-protein phosphatase non-receptor type 18",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:26469);  (R-HSA-8863795);  (R-HSA-9008059)",
        "pathway_count": 3,
        "publication_count": 50,
        "publication_id_list": "11145836;11237011;11839743;12096920;12239347;12381835;12809600;14660651;14679216;15527767;15951569;16094384;16303740;17016520;18390730;19167335;19901323;19933325;20935647;21376233;23186163;24481253;25081058;25729923;26154972;26992070;27060871;28092676;28832583;28834231;29242379;29557506;30429286;31092671;31844290;32027948;32157095;32488085;32983136;33968037;34171305;35051231;35154160;35580925;36846716;38787319;7541030;7542744;8950995;9461599",
        "class_list": "",
        "function": "BDP1 has a role in negative regulation of HER2 signaling, [RefSeq, PubMed]; Differentially dephosphorylate autophosphorylated tyrosine kinases which are known to be overexpressed in tumor tissues., [UniProtKB]; Hepatitis B Virus X Protein Represses Expression of Tumor Suppressor PTPN18 in Hepatocellular Carcinoma., [RefSeq, PubMed]; Novel isoform of PTPN18 based on analysis of expressed sequence tags was discovered; deletion of 4 exons in the catalytic domain of the isoform may alter enzymatic activity; 2 of the novel isoform predictions were experimentally validated through RT-PCR, [RefSeq, PubMed]; PTPN18 Serves as a Potential Oncogene for Glioblastoma by Enhancing Immune Suppression. Publication Status: Online-Only, [RefSeq, PubMed]; Phospho-PTM proteomic discovery of novel EPO- modulated kinases and phosphatases, including PTPN18 as a positive regulator of EPOR/JAK2 Signaling., [RefSeq, PubMed]; The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, the mitotic cycle, and oncogenic transformation. This PTP contains a PEST motif, which often serves as a protein-protein interaction domain, and may be related to protein intracellular half-live. This protein can differentially dephosphorylate autophosphorylated tyrosine kinases that are overexpressed in tumor tissues, and it appears to regulate HER2, a member of the epidermal growth factor receptor family of receptor tyrosine kinases. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 9,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4E1E6;Q53P42",
        "ec_number_list": [
            {
                "id": "3.1.3.16",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.16",
                "type": "external"
            },
            {
                "id": "3.1.3.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.48",
                "type": "external"
            },
            {
                "id": "3.1.3.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.21",
                "type": "external"
            },
            {
                "id": "3.1.3.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.18",
                "type": "external"
            },
            {
                "id": "3.1.3.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.-",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
                "type": "external"
            },
            {
                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
                "type": "external"
            },
            {
                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
                "type": "external"
            },
            {
                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004726 non-membrane spanning protein tyrosine phosphatase activity;GO:0004725 protein tyrosine phosphatase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006470 protein dephosphorylation;GO:1901185 negative regulation of ERBB signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 5.1,
        "record_id": "Q99952-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P02771-1",
        "uniprot_id": [
            {
                "id": "FETA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P02771",
                "type": "external"
            }
        ],
        "mass": 68678.0,
        "length": 609,
        "protein_name": "Alpha-fetoprotein",
        "gene_name": "AFP",
        "organism": "Human",
        "refseq_name": "alpha-fetoprotein isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001125",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001125",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "AFP; HPAFP",
        "gene_names_refseq": "AFPD; AFP; FETA; HPAFP",
        "protein_names_uniprotkb": "Alpha-fetoprotein; Alpha-1-fetoprotein; Alpha-fetoglobulin",
        "protein_names_refseq": "alpha-1-fetoprotein; alpha-fetoglobulin; alpha-fetoprotein isoform 1 precursor",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); endometrial cancer (Disease Ontology:DOID:1380); hepatitis C (Disease Ontology:DOID:1883); endodermal sinus tumor (Disease Ontology:DOID:1911); hepatitis (Disease Ontology:DOID:2237); teratocarcinoma (Disease Ontology:DOID:3305); embryonal carcinoma (Disease Ontology:DOID:3308); renal cell carcinoma (Disease Ontology:DOID:4450); hepatocellular carcinoma (Disease Ontology:DOID:684); obsolete congenital deficiency in alpha-fetoprotein (MONDO:MONDO:0014424); obsolete hereditary persistence of alpha-fetoprotein (MONDO:MONDO:0014425)",
        "pathway": " (hsa:174);  (R-HSA-381426);  (R-HSA-8957275)",
        "pathway_count": 3,
        "publication_count": 119,
        "publication_id_list": "10.1038/emboj.2013.79;10026136;10077652;10218588;10512690;10614670;10681634;10810289;10898936;10912521;10951195;10990447;11158056;11237011;11250653;11264294;11316783;11522292;11606061;11739083;11751371;11788658;12241545;12379487;12466191;12717392;12810533;12904166;1370451;1383255;15126567;15280901;15308688;15469690;15485880;15525596;15642270;16534867;1694115;17047378;1709810;17249697;17312271;17522429;17985932;18422961;18854864;19362088;20012107;21078325;23345538;23584533;2414772;2436661;2476804;2479552;25382443;25645385;2580830;26091039;28188748;28514659;29443377;29557506;30418433;30561769;30779550;30815394;31222486;31844290;31849039;32132566;32350084;32395117;32425926;33043033;34270940;35051231;35251023;35536554;35580925;38253038;38310085;38505913;38619448;38665916;38678117;4138095;6187626;6192439;6192908;70228;71198;7511099;7519608;7523391;7525263;7525634;7525824;7527330;7538844;7543116;7588299;7679920;7683646;7684942;7686446;7689487;80265;8781553;8817670;8894645;8964575;89900;9497324;9709957;9733769;9786878;9922210",
        "class_list": "",
        "function": "Alpha-fetoprotein: Past, present, and future. Review article Publication Status: Online-Only, [RefSeq, PubMed]; Binds copper, nickel, and fatty acids as well as, and bilirubin less well than, serum albumin. Only a small percentage (less than 2%) of the human AFP shows estrogen-binding properties., [UniProtKB]; Combination of serum alpha-fetoprotein, PIVKA- and glypican-3 in diagnosis of hepatocellular carcinoma: a meta-analysis. Publication Status: Online-Only, [RefSeq, PubMed]; Role of Alpha-Fetoprotein in the Pathogenesis of Cancer. Review article, [RefSeq, PubMed]; Structural characteristics of alpha-fetoprotein, including N-glycosylation, metal ion and fatty acid binding sites. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes alpha-fetoprotein, a major plasma protein produced by the yolk sac and the liver during fetal life. Alpha-fetoprotein expression in adults is often associated with hepatocarcinoma and with teratoma, and has prognostic value for managing advanced gastric cancer. However, hereditary persistance of alpha-fetoprotein may also be found in individuals with no obvious pathology. The protein is thought to be the fetal counterpart of serum albumin, and the alpha-fetoprotein and albumin genes are present in tandem in the same transcriptional orientation on chromosome 4. Alpha-fetoprotein is found in monomeric as well as dimeric and trimeric forms, and binds copper, nickel, fatty acids and bilirubin. The level of alpha-fetoprotein in amniotic fluid is used to measure renal loss of protein to screen for spina bifida and anencephaly. [provided by RefSeq, Oct 2019]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 3,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 3,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 3,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 30,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "diagnostic",
        "glycan_count": 49,
        "disease_count": 11,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RBU3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046872 metal ion binding;GO:0036094 small molecule binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0031667 response to nutrient levels",
        "synthesized_glycan_count": 0,
        "hit_score": 17.4,
        "record_id": "P02771-1",
        "record_type": "protein",
        "filter_code": "1000000.1000111.100000.000000000001000000.1100100000001.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14682-1",
        "uniprot_id": [
            {
                "id": "ENC1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14682",
                "type": "external"
            }
        ],
        "mass": 66130.0,
        "length": 589,
        "protein_name": "Ectoderm-neural cortex protein 1",
        "gene_name": "ENC1",
        "organism": "Human",
        "refseq_name": "ectoderm-neural cortex protein 1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001243503",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001243503",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ENC1; KLHL37; NRPB; PIG10",
        "gene_names_refseq": "ENC-1; ENC1; KLHL35; KLHL37; NRPB; PIG10; TP53I10",
        "protein_names_uniprotkb": "Ectoderm-neural cortex protein 1; ENC-1; Kelch-like protein 37; Nuclear matrix protein NRP/B; p53-induced gene 10 protein",
        "protein_names_refseq": "ectoderm-neural cortex protein 1 isoform 1; ectoderm-neural cortex protein 1; ectodermal-neural cortex 1 (with BTB domain); ectodermal-neural cortex 1 (with BTB-like domain); kelch-like 35; kelch-like family member 37; kelch-like protein 37; nuclear matrix protein NRP/B; nuclear restricted protein, BTB domain-like (brain); p53-induced gene 10 protein; tumor protein p53 inducible protein 10",
        "tax_id": 9606,
        "disease": "nicotine dependence (Disease Ontology:DOID:0050742); retinal disease (Disease Ontology:DOID:5679); retinal degeneration (Disease Ontology:DOID:8466)",
        "pathway": " (hsa:8507)",
        "pathway_count": 1,
        "publication_count": 73,
        "publication_id_list": "11237011;15983046;17924679;18452278;19424503;23481700;24714562;25576301;26154972;26375851;26728094;26992070;27397612;27846572;27869121;27920218;28218747;28832583;28834231;28904123;29242379;29437277;29508533;29557506;29632046;29632711;29786170;29789417;30379171;30429286;30779550;30833945;31154438;31222486;31844290;31848261;31921104;31937595;32157095;32161166;32265295;32357974;32387766;32488085;32502341;32938616;33141586;33298915;33537174;33592498;33717175;33936100;33968037;33981976;34087483;34171305;34185709;34362881;34509645;34932366;35051231;35318648;35580925;36010968;36241641;36284347;36581221;37938771;38177640;39455818;9305847;9566959;9683534",
        "class_list": "",
        "function": "Aberrant super-enhancer-driven oncogene ENC1 promotes the radio-resistance of breast carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Actin-binding protein involved in the regulation of neuronal process formation and in differentiation of neural crest cells. Down-regulates transcription factor NF2L2/NRF2 by decreasing the rate of protein synthesis and not via a ubiquitin-mediated proteasomal degradation mechanism., [UniProtKB, PubMed]; Comprehensive pan-cancer analysis reveals ENC1 as a promising prognostic biomarker for tumor microenvironment and therapeutic responses. Publication Status: Online-Only, [RefSeq, PubMed]; The emerging role of ectodermal neural cortex 1 in cancer. Review article Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the kelch-related family of actin-binding proteins. The encoded protein plays a role in the oxidative stress response as a regulator of the transcription factor Nrf2, and expression of this gene may play a role in malignant transformation. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 3,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DHJ1;E9PFU0;O75464;Q9UPG9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005856 cytoskeleton;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0007399 nervous system development;GO:0010976 positive regulation of neuron projection development;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0017148 negative regulation of translation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.6,
        "record_id": "O14682-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5NDL2-1",
        "uniprot_id": [
            {
                "id": "EOGT_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5NDL2",
                "type": "external"
            }
        ],
        "mass": 62011.0,
        "length": 527,
        "protein_name": "EGF domain-specific O-linked N-acetylglucosamine transferase",
        "gene_name": "EOGT",
        "organism": "Human",
        "refseq_name": "EGF domain-specific O-linked N-acetylglucosamine transferase isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_001265618",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001265618",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EOGT; AER61; C3orf64; EOGT1",
        "gene_names_refseq": "AER61; AOS4; C3orf64; EOGT1; EOGT",
        "protein_names_uniprotkb": "EGF domain-specific O-linked N-acetylglucosamine transferase; 2.4.1.255; Extracellular O-linked N-acetylglucosamine transferase",
        "protein_names_refseq": "AER61 glycosyltransferase; EGF domain-specific O-linked N-acetylglucosamine (GlcNAc) transferase; EGF domain-specific O-linked N-acetylglucosamine transferase isoform a precursor; EGF-O-GlcNAc transferase; extracellular O-linked N-acetylglucosamine transferase",
        "tax_id": 9606,
        "disease": "Adams-Oliver syndrome (Disease Ontology:DOID:0060227)",
        "pathway": " (hsa:285203)",
        "pathway_count": 1,
        "publication_count": 22,
        "publication_id_list": "10.1101/2023.09.13.557529;11237011;23090970;23522784;23671640;23860037;24190977;27600516;29244071;31368252;31844290;32938616;32983136;33515675;33562410;33968037;34725712;35051231;35069551;37074911;37217939;38665916",
        "class_list": "glycogene;glycosyltransferase",
        "function": "Analysis of midluteal endometrial biopsies revealed an inverse correlation between endometrial EOGT and ENHO expression and body mass index. obesity impairs the EOGT-adropin axis in decidual cells, which in turn points toward a mechanistic link between metabolic disorders and adverse pregnancy outcome., [RefSeq, PubMed]; Bioinformatics and Functional Analyses Implicate Potential Roles for EOGT and L-fringe in Pancreatic Cancers. Publication Status: Online-Only, [RefSeq, PubMed]; C.1074delA mutation segregates with Adams-Oliver syndrome in the Bedouin family., [RefSeq, PubMed]; Catalyzes the transfer of a single N-acetylglucosamine from UDP-GlcNAc to a serine or threonine residue in extracellular proteins resulting in their modification with a beta-linked N-acetylglucosamine (O-GlcNAc). Specifically glycosylates the Thr residue located between the fifth and sixth conserved cysteines of folded EGF-like domains., [UniProtKB, PubMed]; EOGT Correlated With Immune Infiltration: A Candidate Prognostic Biomarker for Hepatocellular Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; Mutations in EOGT confirm the genetic heterogeneity of autosomal-recessive Adams-Oliver syndrome., [RefSeq, PubMed]; SHCBP1 interacting with EOGT enhances O-GlcNAcylation of NOTCH1 and promotes the development of pancreatic cancer., [RefSeq, PubMed]; This gene encodes an enzyme that acts in the lumen of the endoplasmic reticulum to catalyze the transfer of N-acetylglucosamine to serine or threonine residues of extracellular-targeted proteins. This enzyme modifies proteins containing eukaryotic growth factor (EGF)-like domains, including the Notch receptor, thereby regulating developmental signalling. Mutations in this gene have been observed in individuals with Adams-Oliver syndrome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2015]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 1,
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        "reported_mutagensis": 1,
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        "reported_snv": 665,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 7,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K2U1;B4DFH5;L7X1M5;Q6MZY0;Q6P985;Q6ZTV0",
        "ec_number_list": [
            {
                "id": "2.4.1.255",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.255",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0097363 protein O-acetylglucosaminyltransferase activity",
        "go_cellular_component": "GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0006493 protein O-linked glycosylation",
        "synthesized_glycan_count": 5,
        "hit_score": 3.2,
        "record_id": "Q5NDL2-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000000.100.11000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IX29-1",
        "uniprot_id": [
            {
                "id": "FBX16_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IX29",
                "type": "external"
            }
        ],
        "mass": 34588.0,
        "length": 292,
        "protein_name": "F-box only protein 16",
        "gene_name": "FBXO16",
        "organism": "Human",
        "refseq_name": "F-box only protein 16 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001245140",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001245140",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FBXO16; FBX16",
        "gene_names_refseq": "FBX16; FBXO16",
        "protein_names_uniprotkb": "F-box only protein 16",
        "protein_names_refseq": "F-box only protein 16 isoform 2; F-box only protein 16",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:157574)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "11237011;12243353;19413330;26992070;27920218;28121444;28218747;29437277;30315122;30530053;30714168;31844290;32157095;32387766;32488085;33592498;34333526;39384743;40529355",
        "class_list": "",
        "function": "FBXO16 was localized to the human chromosome 8p12. The FBXO16 gene consisted of 9 exons that spanned 67,816 bp of human genomic DNA, [RefSeq, PubMed]; FBXO16-mediated hnRNPL ubiquitination and degradation plays a tumor suppressor role in ovarian cancer. Publication Status: Online-Only, [RefSeq, PubMed]; MIR937 amplification potentiates ovarian cancer progression by attenuating FBXO16 inhibition on ULK1-mediated autophagy. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate recognition component of an SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex that mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Functions as a putative tumor suppressor by targeting nuclear beta-catenin/CTNNB1 for degradation independently of upstream activating signals, thereby inhibiting epithelial-to-mesenchymal transition (PubMed:30714168). Controls the ubiquitination and degradation of hnRNPL (PubMed:34333526). Negatively regulates NF-kappa-B signaling by mediating the polyubiquitination and degradation of RELA (PubMed:40529355). Inhibits autophagy by promoting 'Lys-48'-linked polyubiquitination of the serine/threonine-protein kinase ULK1 (PubMed:39384743)., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; That FBXO16 functions as a putative tumor suppressor by forming an SCF(FBXO16) complex that targets nuclear beta-catenin in a unique manner for ubiquitination and subsequent proteasomal degradation to prevent malignancy, [RefSeq, PubMed]; This gene encodes a member of the F-box protein family, members of which are characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into three classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbx class. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Apr 2012]., [RefSeq]; We show that due to low expression of FBXO16, the beta-catenin is not targeted in glioma cells leading to its nuclear accumulation resulting in active Wnt signaling. Activated Wnt signaling potentiates the glioma cells toward a highly proliferative and malignant state., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q3T1B2;Q3T1B3;Q3T1B4",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q8IX29-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A1A519-1",
        "uniprot_id": [
            {
                "id": "F170A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A1A519",
                "type": "external"
            }
        ],
        "mass": 37158.0,
        "length": 330,
        "protein_name": "Protein FAM170A",
        "gene_name": "FAM170A",
        "organism": "Human",
        "refseq_name": "protein FAM170A isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001157463",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157463",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM170A; ZNFD",
        "gene_names_refseq": "FAM170A; ZNFD",
        "protein_names_uniprotkb": "Protein FAM170A; Zinc finger domain-containing protein; Zinc finger protein ZNFD",
        "protein_names_refseq": "Znf domain containing protein; protein FAM170A isoform 2; protein FAM170A; zinc finger domain-containing protein; zinc finger protein ZNFD",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:340069)",
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        "publication_count": 2,
        "publication_id_list": "11237011;20162441",
        "class_list": "",
        "function": "Acts as a nuclear transcription factor that positively regulates the expression of heat shock genes (PubMed:20162441). Binds to heat shock promoter elements (HSE) (PubMed:20162441). Necessary for normal sperm head morphology, efficient spermiation, and sperm progressive motility (By similarity). Plays a crucial role in sperm chromatin remodeling by promoting the nuclear translocation and deubiquitinating activity of USP7 on histone H2A and H2B variants (By similarity). This ensures the timely removal of core histones, proper expression and degradation of transition proteins, and efficient incorporation of protamines during spermiogenesis (By similarity)., [UniProtKB, PubMed, UniProtKB]; Data indicate that ZNFD is probably a new type of C(2)H(2) zinc finger protein that may activate AP1 transcriptional activities., [RefSeq, PubMed]",
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        "missing_score": 10000,
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        "secondary_ac_list": "Q66LM8;Q7Z4V2;Q8IW94",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0009566 fertilization;GO:0045893 positive regulation of DNA-templated transcription;GO:0006366 transcription by RNA polymerase II",
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        "record_id": "A1A519-1",
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    },
    {
        "uniprot_canonical_ac": "Q96RT1-1",
        "uniprot_id": [
            {
                "id": "ERBIN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96RT1",
                "type": "external"
            }
        ],
        "mass": 158298.0,
        "length": 1412,
        "protein_name": "Erbin",
        "gene_name": "ERBIN",
        "organism": "Human",
        "refseq_name": "erbin isoform 7",
        "refseq_ac": [
            {
                "id": "NP_001006600",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006600",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ERBIN; ERBB2IP; KIAA1225; LAP2",
        "gene_names_refseq": "ERBB2IP; ERBIN; HEL-S-78; LAP2",
        "protein_names_uniprotkb": "Erbin; Densin-180-like protein; Erbb2-interacting protein; Protein LAP2",
        "protein_names_refseq": "densin-180-like protein; epididymis secretory protein Li 78; erbin isoform 7; protein LAP2",
        "tax_id": 9606,
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        "pathway": " (hsa:55914);  (R-HSA-1227986);  (R-HSA-8863795);  (R-HSA-8980692);  (R-HSA-9013026);  (R-HSA-9013106);  (R-HSA-9013149);  (R-HSA-9013404);  (R-HSA-9013408);  (R-HSA-9013423);  (R-HSA-9634285);  (R-HSA-9652282);  (R-HSA-9664565);  (R-HSA-9665233);  (R-HSA-9665244);  (R-HSA-9665245);  (R-HSA-9665246);  (R-HSA-9665247);  (R-HSA-9665249);  (R-HSA-9665250);  (R-HSA-9665251);  (R-HSA-9665348);  (R-HSA-9665686);  (R-HSA-9665737)",
        "pathway_count": 24,
        "publication_count": 499,
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        "class_list": "",
        "function": "Acts as an adapter for the receptor ERBB2, in epithelia. By binding the unphosphorylated 'Tyr-1248' of receptor ERBB2, it may contribute to stabilize this unphosphorylated state (PubMed:16203728). Inhibits NOD2-dependent NF-kappa-B signaling and pro-inflammatory cytokine secretion (PubMed:16203728). Acts as a mediator of keratinocyte differentiation by sequestering SHOC2 away from ERK-activating RAS complexes (PubMed:23524970)., [UniProtKB, PubMed, PubMed, PubMed]; Exosomal ERBB2IP contributes to tumor growth via elevating PSAT1 expression in non-small cell lung carcinoma., [RefSeq, PubMed]; Targeting Erbin-mitochondria axis in platelets/megakaryocytes promotes B cell-mediated antitumor immunity. Erratum:[Cell Metab. 2025 Jul 1;37(7):1615. doi: 10.1016/j.cmet.2025.06.004. PMID: 40541181], [RefSeq, PubMed]; This gene is a member of the leucine-rich repeat and PDZ domain (LAP) family. The encoded protein contains 17 leucine-rich repeats and one PDZ domain. It binds to the unphosphorylated form of the ERBB2 protein and regulates ERBB2 function and localization. It has also been shown to affect the Ras signaling pathway by disrupting Ras-Raf interaction. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]., [RefSeq]",
        "predicted_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "reported_snv": 37,
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        "biomarker_type": "",
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        "secondary_ac_list": "A0AVR1;B4E3F1;B7ZLV9;E7EQW9;E9PCR8;Q1RMD0;Q86W38;Q9NR18;Q9NW48;Q9ULJ5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005200 structural constituent of cytoskeleton;GO:0005176 ErbB-2 class receptor binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0016323 basolateral plasma membrane",
        "go_biological_process": "GO:0032496 response to lipopolysaccharide;GO:0035556 intracellular signal transduction;GO:0071638 negative regulation of monocyte chemotactic protein-1 production;GO:0071356 cellular response to tumor necrosis factor;GO:0070433 negative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 50.3,
        "record_id": "Q96RT1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000001.000.00000",
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    },
    {
        "uniprot_canonical_ac": "P01588-1",
        "uniprot_id": [
            {
                "id": "EPO_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P01588",
                "type": "external"
            }
        ],
        "mass": 21307.0,
        "length": 193,
        "protein_name": "Erythropoietin",
        "gene_name": "EPO",
        "organism": "Human",
        "refseq_name": "erythropoietin precursor",
        "refseq_ac": [
            {
                "id": "NP_000790",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000790",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPO",
        "gene_names_refseq": "DBAL; ECYT5; EPO; EP; MVCD2",
        "protein_names_uniprotkb": "Erythropoietin",
        "protein_names_refseq": "epoetin; erythropoietin precursor",
        "tax_id": 9606,
        "disease": "limb ischemia (Disease Ontology:DOID:0050852); familial erythrocytosis 5 (Disease Ontology:DOID:0080290); Alzheimer's disease (Disease Ontology:DOID:10652); diabetic angiopathy (Disease Ontology:DOID:11713); nephrotic syndrome (Disease Ontology:DOID:1184); neurodegenerative disease (Disease Ontology:DOID:1289); retinopathy of prematurity (Disease Ontology:DOID:13025); porphyria (Disease Ontology:DOID:13268); Diamond-Blackfan anemia (Disease Ontology:DOID:1339); Parkinson's disease (Disease Ontology:DOID:14330); breast cancer (Disease Ontology:DOID:1612); glaucoma (Disease Ontology:DOID:1686); transient cerebral ischemia (Disease Ontology:DOID:224); anemia (Disease Ontology:DOID:2355); acute kidney failure (Disease Ontology:DOID:3021); high grade glioma (Disease Ontology:DOID:3070); amyotrophic lateral sclerosis (Disease Ontology:DOID:332); middle cerebral artery infarction (Disease Ontology:DOID:3525); placental insufficiency (Disease Ontology:DOID:3891); macular retinal edema (Disease Ontology:DOID:4449); cholangiocarcinoma (Disease Ontology:DOID:4947); retinal detachment (Disease Ontology:DOID:5327); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); vascular dementia (Disease Ontology:DOID:8725); diabetic retinopathy (Disease Ontology:DOID:8947); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); hypoglycemia (Disease Ontology:DOID:9993); microvascular complications of diabetes, susceptibility to, 2 (MONDO:MONDO:0012962); Diamond-Blackfan anemia-like (MONDO:MONDO:0060662)",
        "pathway": " (hsa:2056);  (R-HSA-1234158);  (R-HSA-9006335);  (R-HSA-9027276);  (R-HSA-9027277);  (R-HSA-9027283);  (R-HSA-9027284)",
        "pathway_count": 7,
        "publication_count": 108,
        "publication_id_list": "10194437;10202154;10455108;10498627;10764840;11007921;11063749;11124936;11156414;11231127;11443118;11598010;11739166;11805077;11959977;11959990;12506011;1375226;1377053;1443598;14668441;15149544;15184875;15459301;15644415;1569084;15749848;17108343;17804822;18187047;1820196;18452278;18458324;1907570;19665053;19788888;2124546;21479871;2163696;22509308;22678432;22935486;24584613;24613356;24714562;25092874;2550193;25582283;25683712;26160453;27651169;2813359;28142147;28283061;29514032;3179269;3219367;32578997;3346214;38272667;38302546;3838366;38560469;3865178;39047915;3949763;6698989;7527189;7539782;7539918;7608147;7737204;7744007;7781780;7836384;8034732;8054720;8387214;8396923;8400282;8460945;8477709;8663540;8677749;8756616;8861946;8917528;8981093;9000051;9027736;9057652;9079689;9162069;9209406;9334184;9573010;9587401;9632793;9657743;9722506;9774108;9783743;9799793;9822602;9837784;9840812;9923445;9974393",
        "class_list": "",
        "function": "EPO promotes the progression of rheumatoid arthritis by inducing desialylation via increasing the expression of neuraminidase 3. Publication Status: Online-Only, [RefSeq, PubMed]; Erythropoietin alleviates lung ischemia-reperfusion injury by activating the FGF23/FGFR4/ERK signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Erythropoietin enhances iron bioavailability in HepG2 cells by downregulating hepcidin through mTOR, C/EBPalpha and HIF-1alpha., [RefSeq, PubMed]; Hormone involved in the regulation of erythrocyte proliferation and differentiation and the maintenance of a physiological level of circulating erythrocyte mass (PubMed:28283061). Binds to EPOR leading to EPOR dimerization and JAK2 activation thereby activating specific downstream effectors, including STAT1 and STAT3 (PubMed:9774108)., [UniProtKB, PubMed, PubMed]; Serum erythropoietin in acute ischemic stroke: preliminary findings. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a secreted, glycosylated cytokine composed of four alpha helical bundles. The encoded protein is mainly synthesized in the kidney, secreted into the blood plasma, and binds to the erythropoietin receptor to promote red blood cell production, or erythropoiesis, in the bone marrow. Expression of this gene is upregulated under hypoxic conditions, in turn leading to increased erythropoiesis and enhanced oxygen-carrying capacity of the blood. Expression of this gene has also been observed in brain and in the eye, and elevated expression levels have been observed in diabetic retinopathy and ocular hypertension. Recombinant forms of the encoded protein exhibit neuroprotective activity against a variety of potential brain injuries, as well as antiapoptotic functions in several tissue types, and have been used in the treatment of anemia and to enhance the efficacy of cancer therapies. [provided by RefSeq, Aug 2017]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 3,
        "reported_o_glycosites": 1,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 57,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 18,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 208,
        "disease_count": 33,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q2M2L6;Q549U2;Q9UDZ0;Q9UEZ5;Q9UHA0",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030295 protein kinase activator activity;GO:0005125 cytokine activity;GO:0005179 hormone activity;GO:0005128 erythropoietin receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0009986 cell surface;GO:0044297 cell body",
        "go_biological_process": "GO:0046579 positive regulation of Ras protein signal transduction;GO:0043249 erythrocyte maturation;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0007165 signal transduction;GO:0008284 positive regulation of cell population proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 32.3,
        "record_id": "P01588-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P32314-1",
        "uniprot_id": [
            {
                "id": "FOXN2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P32314",
                "type": "external"
            }
        ],
        "mass": 47161.0,
        "length": 431,
        "protein_name": "Forkhead box protein N2",
        "gene_name": "FOXN2",
        "organism": "Human",
        "refseq_name": "forkhead box protein N2 isoform a",
        "refseq_ac": [
            {
                "id": "NP_002149",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002149",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FOXN2; HTLF",
        "gene_names_refseq": "FOXN2; HTLF",
        "protein_names_uniprotkb": "Forkhead box protein N2; Human T-cell leukemia virus enhancer factor",
        "protein_names_refseq": "forkhead box protein N2 isoform a; forkhead box protein N2; human T-cell leukemia virus enhancer factor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:3344)",
        "pathway_count": 1,
        "publication_count": 44,
        "publication_id_list": "11237011;1639393;21531217;24714562;24715725;26154972;26728094;26802049;26992070;27397612;27846572;27862975;28832583;28855257;28904123;29242379;29493099;29557506;30379171;30410026;30484775;31217245;31844290;32157095;32488085;32502341;32897882;32938616;32983136;33141586;33298915;33633747;33717175;33912179;33936100;33968037;34171305;35008435;35051231;35580925;37318741;37938771;38705565;38954805",
        "class_list": "",
        "function": "Binds to the purine-rich region in HTLV-I LTR., [UniProtKB]; Bmi1 facilitates the progression of cholangiocarcinoma by inhibiting Foxn2 expression dependent on a histone H2A ubiquitination manner., [RefSeq, PubMed]; FOXN2, identified as a novel biomarker in serum, modulates the transforming growth factor-beta signaling pathway through its interaction with partitioning defective 6 homolog alpha, contributing to the pathogenesis of gastric cancer., [RefSeq, PubMed]; HLTF methylation may exist in gastric cardia dysplasia stages and may play important role in the development of gastric cardia adenocarcinoma., [RefSeq, PubMed]; HOXC6-Mediated miR-188-5p Expression Induces Cell Migration through the Inhibition of the Tumor Suppressor FOXN2. Publication Status: Online-Only, [RefSeq, PubMed]; HTLF is a RUNX1 target whose down-regulation promotes genomic instability and correlates with complex cytogenetic abnormalities in acute myeloid leukemia patients., [RefSeq, PubMed]; Hsa_circ_0001741 Suppresses Ovarian Cancer Cell Proliferations Through Adsorption of miR-188-5p and Promotion of FOXN2 Expression., [RefSeq, PubMed]; This gene encodes a forkhead domain binding protein and may function in the transcriptional regulation of the human T-cell leukemia virus long terminal repeat. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q15769;Q6P4Q2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003700 DNA-binding transcription factor activity;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0000987 cis-regulatory region sequence-specific DNA binding;GO:1990837 sequence-specific double-stranded DNA binding;GO:0043565 sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "P32314-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q08881-1",
        "uniprot_id": [
            {
                "id": "ITK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q08881",
                "type": "external"
            }
        ],
        "mass": 71831.0,
        "length": 620,
        "protein_name": "Tyrosine-protein kinase ITK/TSK",
        "gene_name": "ITK",
        "organism": "Human",
        "refseq_name": "tyrosine-protein kinase ITK/TSK",
        "refseq_ac": [
            {
                "id": "NP_005537",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005537",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ITK; EMT; LYK",
        "gene_names_refseq": "EMT; ITK; LPFS1; LYK; PSCTK2",
        "protein_names_uniprotkb": "Tyrosine-protein kinase ITK/TSK; 2.7.10.2; IL-2-inducible T-cell kinase; Interleukin-2-inducible T-cell kinase; Kinase EMT; T-cell-specific kinase; Tyrosine-protein kinase Lyk",
        "protein_names_refseq": "IL-2-inducible T-cell kinase; T-cell-specific kinase; homolog of mouse T-cell itk/tsk; interleukin-2-inducible T-cell kinase; kinase EMT; tyrosine-protein kinase ITK/TSK; tyrosine-protein kinase LYK",
        "tax_id": 9606,
        "disease": "lymphoproliferative syndrome 1 (Disease Ontology:DOID:0060707)",
        "pathway": " (hsa:3702);  (R-HSA-202433);  (R-HSA-2871809)",
        "pathway_count": 3,
        "publication_count": 68,
        "publication_id_list": "10671560;10747096;10795735;10811803;10860980;11015619;11030334;11048639;11237011;11390650;11395409;11607830;11752630;12186560;12573241;12682224;12842872;12975316;14510693;15144186;15308100;15661896;17060314;17192257;17344846;17439160;17502104;17652306;17897671;18296442;19425169;19523959;19690332;19807924;20596523;21725281;23071622;26154972;28832583;29242379;29493099;29557506;31507602;32157095;32488085;32983136;34087483;35051231;35210549;35580925;36010968;36284347;36326697;37992572;7518558;7565724;8364206;8504851;8629002;8630736;8631904;8798379;8799126;8824201;9115214;9312162;9701039;9846482",
        "class_list": "",
        "function": "ITK independent development of Th17 responses during hypersensitivity pneumonitis driven lung inflammation. Publication Status: Online-Only, [RefSeq, PubMed]; Inherited human ITK deficiency impairs IFN-gamma immunity and underlies tuberculosis., [RefSeq, PubMed]; Targeting kinase ITK treats autoimmune arthritis via orchestrating T cell differentiation and function., [RefSeq, PubMed]; This gene encodes an intracellular tyrosine kinase expressed in T-cells. The protein contains both SH2 and SH3 domains which are often found in intracellular kinases. It is thought to play a role in T-cell proliferation and differentiation. [provided by RefSeq, Jul 2008]., [RefSeq]; Tyrosine kinase that plays an essential role in regulation of the adaptive immune response. Regulates the development, function and differentiation of conventional T-cells and nonconventional NKT-cells. When antigen presenting cells (APC) activate T-cell receptor (TCR), a series of phosphorylation lead to the recruitment of ITK to the cell membrane, in the vicinity of the stimulated TCR receptor, where it is phosphorylated by LCK. Phosphorylation leads to ITK autophosphorylation and full activation. Once activated, phosphorylates PLCG1, leading to the activation of this lipase and subsequent cleavage of its substrates. In turn, the endoplasmic reticulum releases calcium in the cytoplasm and the nuclear activator of activated T-cells (NFAT) translocates into the nucleus to perform its transcriptional duty. Phosphorylates 2 essential adapter proteins: the linker for activation of T-cells/LAT protein and LCP2. Then, a large number of signaling molecules such as VAV1 are recruited and ultimately lead to lymphokine production, T-cell proliferation and differentiation (PubMed:12186560, PubMed:12682224, PubMed:21725281). Required for TCR-mediated calcium response in gamma-delta T-cells, may also be involved in the modulation of the transcriptomic signature in the Vgamma2-positive subset of immature gamma-delta T-cells (By similarity). Phosphorylates TBX21 at 'Tyr-530' and mediates its interaction with GATA3 (By similarity)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 7,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R752;Q32ML7",
        "ec_number_list": [
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.1.4.11",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.11",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0008270 zinc ion binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0005911 cell-cell junction",
        "go_biological_process": "GO:0007165 signal transduction;GO:0035556 intracellular signal transduction;GO:0006968 cellular defense response;GO:0042110 T cell activation;GO:0050852 T cell receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 6.9,
        "record_id": "Q08881-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BXM7-1",
        "uniprot_id": [
            {
                "id": "PINK1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BXM7",
                "type": "external"
            }
        ],
        "mass": 62769.0,
        "length": 581,
        "protein_name": "Serine/threonine-protein kinase PINK1, mitochondrial",
        "gene_name": "PINK1",
        "organism": "Human",
        "refseq_name": "serine/threonine-protein kinase PINK1, mitochondrial precursor",
        "refseq_ac": [
            {
                "id": "NP_115785",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_115785",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PINK1",
        "gene_names_refseq": "BRPK; PARK6; PINK1",
        "protein_names_uniprotkb": "Serine/threonine-protein kinase PINK1, mitochondrial; 2.7.11.1; BRPK; PTEN-induced putative kinase protein 1",
        "protein_names_refseq": "PTEN induced putative kinase 1; PTEN-induced putative kinase protein 1; protein kinase BRPK; serine/threonine-protein kinase PINK1, mitochondrial precursor; serine/threonine-protein kinase PINK1, mitochondrial",
        "tax_id": 9606,
        "disease": "Parkinson's disease 6 (Disease Ontology:DOID:0060369); late onset Parkinson's disease (Disease Ontology:DOID:0060892); early-onset Parkinson's disease (Disease Ontology:DOID:0060894); metabolic dysfunction-associated steatohepatitis (Disease Ontology:DOID:0080547); Parkinsonism (Disease Ontology:DOID:0080855); Hirschsprung's disease (Disease Ontology:DOID:10487); Parkinson's disease (Disease Ontology:DOID:14330); testicular cancer (Disease Ontology:DOID:2998)",
        "pathway": " (hsa:65018);  (R-HSA-5205685);  (R-HSA-9614657)",
        "pathway_count": 3,
        "publication_count": 122,
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        "class_list": "",
        "function": "Autosomal recessive early onset parkinsonism is linked to three loci: PARK2, PARK6, and PARK7., [RefSeq, PubMed]; Deciphering the neuroprotective mechanisms of RACK1 in cerebral ischemia-reperfusion injury: Pioneering insights into mitochondrial autophagy and the PINK1/Parkin axis., [RefSeq, PubMed]; PINK1/Park2-Mediated Mitophagy Relieve Non-Alcoholic Fatty Liver Disease., [RefSeq, PubMed]; Serine/threonine-protein kinase which acts as a sensor of mitochondrial damage and protects against mitochondrial dysfunction during cellular stress (PubMed:40080546). It phosphorylates mitochondrial proteins to coordinate mitochondrial quality control mechanisms that remove and replace dysfunctional mitochondrial components (PubMed:14607334, PubMed:15087508, PubMed:18443288, PubMed:18957282, PubMed:19229105, PubMed:19966284, PubMed:20404107, PubMed:20547144, PubMed:20798600, PubMed:22396657, PubMed:23620051, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:24896179, PubMed:24898855, PubMed:25527291, PubMed:32484300). In healthy mitochondria, PINK1 is translocated across the mitochondrial outer membrane (MOM) via the translocase of the outer membrane (TOM) complex, and inserted into the mitochondrial inner membrane (MIM) via the translocase of the inner membrane (TIM23) complex where it is cleaved and released into the cytosol (PubMed:40080546). Depending on the severity of mitochondrial damage, activity ranges from preventing apoptosis and stimulating mitochondrial biogenesis to eliminating severely damaged mitochondria via PINK1-PRKN-dependent mitophagy (PubMed:14607334, PubMed:15087508, PubMed:18443288, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:22396657, PubMed:23620051, PubMed:23933751, PubMed:24898855, PubMed:32047033, PubMed:32484300). When cellular stress results in irreversible mitochondrial damage, PINK1 accumulates at the outer mitochondrial membrane (OMM) where it phosphorylates pre-existing polyubiquitin chains at 'Ser-65', recruits PRKN from the cytosol to the OMM and activates PRKN by phosphorylation at 'Ser-65'; activated PRKN then ubiquitinates VDAC1 and other OMM proteins to initiate mitophagy (PubMed:14607334, PubMed:15087508, PubMed:19966284, PubMed:20404107, PubMed:20798600, PubMed:23754282, PubMed:23933751, PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25474007, PubMed:25527291, PubMed:32047033, PubMed:40080546). The PINK1-PRKN pathway also promotes fission of damaged mitochondria through phosphorylation and PRKN-dependent degradation of mitochondrial proteins involved in fission such as MFN2 (PubMed:18443288, PubMed:23620051, PubMed:24898855). This prevents the refusion of unhealthy mitochondria with the mitochondrial network or initiates mitochondrial fragmentation facilitating their later engulfment by autophagosomes (PubMed:18443288, PubMed:23620051). Also promotes mitochondrial fission independently of PRKN and ATG7-mediated mitophagy, via the phosphorylation and activation of DNM1L (PubMed:18443288, PubMed:32484300). Regulates motility of damaged mitochondria by promoting the ubiquitination and subsequent degradation of MIRO1 and MIRO2; in motor neurons, this likely inhibits mitochondrial intracellular anterograde transport along the axons which probably increases the chance of the mitochondria undergoing mitophagy in the soma (PubMed:22396657). Required for ubiquinone reduction by mitochondrial complex I by mediating phosphorylation of complex I subunit NDUFA10 (By similarity). Phosphorylates LETM1, positively regulating its mitochondrial calcium transport activity (PubMed:29123128)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Subcellular localization and function analysis of PINK1 mitron in PD progression: Mitron modulates mitochondrial morphology to regulate neuronal death., [RefSeq, PubMed]; The subclinical loss of striatal dopamine storage capacity found in PARK6 carriers implies that the unidentified gene on the short arm of chromosome 1 exhibits either haploinsufficency or a dominant negative effect., [RefSeq, PubMed]; This gene encodes a serine/threonine protein kinase that localizes to mitochondria. It is thought to protect cells from stress-induced mitochondrial dysfunction. Mutations in this gene cause one form of autosomal recessive early-onset Parkinson disease. [provided by RefSeq, Jul 2008]., [RefSeq]",
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        "protein_name": "Prostatic acid phosphatase",
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        "protein_names_refseq": "TMPase; acid phosphatase, prostate; ecto-5'-nucleotidase; prostatic acid phosphatase isoform PAP precursor; prostatic acid phosphotase; protein tyrosine phosphatase ACP3; thiamine monophosphatase",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283)",
        "pathway": " (hsa:55);  (R-HSA-6798695)",
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        "publication_id_list": "10.1101/2023.09.13.557529;10506173;10639192;11237011;11431355;11547122;12525165;1375464;15280042;15289844;15375382;15378520;16024648;16203785;16224270;16738849;17440952;17455230;17638863;17897319;18083097;18940592;19330328;19403677;19451623;19897482;1989985;19995078;20128819;20140431;20498373;20878951;21487525;21677644;21874303;21932426;22529020;23650620;2395659;24190977;24338683;24992895;25662406;26791533;2712834;27393931;27549314;27703488;27893789;28060825;28178396;28188670;28416261;2842184;28622427;29938870;30237853;31844290;32157095;32236612;32350084;32983136;33437477;34078123;34171305;34249152;34677582;35454873;35580925;35878026;36284347;3674882;38341922;7951074;8132635;8692836;9366399;9584846;9655265;9804805",
        "class_list": "",
        "function": "(Microbial infection) Forms amyloid beta-sheet fibrils in semen. These fibrils, termed SEVI (semen-derived enhancer of viral infection) capture HIV virions, attach them to target cells and enhance infection (PubMed:18083097, PubMed:19451623, PubMed:19897482). SEVI amyloid fibrils are degraded by polyphenol epigallocatechin-3-gallate (EGCG), a constituent of green tea (PubMed:19451623). Assembly of SEVI amyloid fibrils and their amplification of HIV infection is inhibited by WW61, a non-natural hexapeptide inhibitor (Trp-His-Lys-chAla-Trp-hydroxyTic) (PubMed:21677644). The target cell attachment and enhancement of HIV infection is also inhibited by surfen (PubMed:19897482). Also similarly boosts XMRV (xenotropic murine leukemia virus-related virus) infection (PubMed:19403677)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; A non-specific tyrosine phosphatase that dephosphorylates a diverse number of substrates under acidic conditions (pH 4-6) including alkyl, aryl, and acyl orthophosphate monoesters and phosphorylated proteins (PubMed:10506173, PubMed:15280042, PubMed:20498373, PubMed:9584846, PubMed:8132635). Has lipid phosphatase activity and inactivates lysophosphatidic acid in seminal plasma (PubMed:10506173, PubMed:15280042)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; Enhanced TDPase and TMPase activities may contribute to the reduction of TDP level in AD patients. The results imply that an imbalance of phosphorylation-dephosphorylation related to thiamine and glucose metabolism may be a potential target for AD prevention and therapy. Publication Status: Online-Only, [RefSeq, PubMed]; Multifunctionality of prostatic acid phosphatase in prostate cancer pathogenesis., [RefSeq, PubMed]; Prostatic acid phosphatase is not a prostate specific target, [RefSeq, PubMed]; Purification, identification and Cryo-EM structure of prostatic acid phosphatase in human semen., [RefSeq, PubMed]; Suppresses pain by functioning as an ecto-5'-nucleotidase, activating A1-adenosine receptors in the dorsal spinal cord., [RefSeq, PubMed]; This gene encodes an enzyme that catalyzes the conversion of orthophosphoric monoester to alcohol and orthophosphate. It is synthesized under androgen regulation and is secreted by the epithelial cells of the prostate gland. An alternatively spliced transcript variant encoding a longer isoform has been found for this gene. This isoform contains a transmembrane domain and is localized in the plasma membrane-endosomal-lysosomal pathway. [provided by RefSeq, Sep 2008]., [RefSeq]; Tyrosine phosphatase that acts as a tumor suppressor of prostate cancer through dephosphorylation of ERBB2 and deactivation of MAPK-mediated signaling (PubMed:20498373). In addition to its tyrosine phosphatase activity has ecto-5'-nucleotidase activity in dorsal root ganglion (DRG) neurons. Generates adenosine from AMP which acts as a pain suppressor (By similarity)., [UniProtKB, UniProtKB, PubMed]; We have measured the intramolecular diffusion of the full length and 8-residue deletion peptides at two different pHs and found a correlation with fibrillization lag time. These results can be explained by a simple kinetic model of the early stages of aggregation in which oligomerization is controlled by the rate of peptide reconfiguration., [RefSeq, PubMed]",
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            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
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            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
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                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
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                "id": "3.2.1.20",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.2.1.20",
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                "id": "2.5.1.18",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.5.1.18",
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                "id": "3.1.3.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.2",
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                "id": "2.4.1.-",
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                "id": "2.4.1.275",
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                "id": "2.4.1.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.22",
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            {
                "id": "2.4.1.38",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.38",
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            {
                "id": "2.4.1.90",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.4.1.90",
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            {
                "id": "3.1.3.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.5",
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            {
                "id": "3.1.3.91",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.91",
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            {
                "id": "3.1.3.89",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.89",
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                "id": "3.1.3.99",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.99",
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                "id": "3.1.3.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.35",
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                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
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                "id": "3.3.2.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10",
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            {
                "id": "3.1.3.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76",
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                "id": "3.4.16.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.16.2",
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                "id": "3.4.23.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-",
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                "id": "2.7.1.77",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.77",
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                "id": "3.1.3.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.67",
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                "id": "7.6.2.-",
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                "id": "2.3.1.51",
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                "id": "2.3.1.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.23",
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                "id": "2.3.1.67",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.67",
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                "id": "2.3.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.25",
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                "id": "3.1.3.27",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.27",
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                "id": "7.6.2.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:7.6.2.1",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0033265 choline binding;GO:0052642 lysophosphatidic acid phosphatase activity;GO:0060090 molecular adaptor activity;GO:0042802 identical protein binding;GO:0042803 protein homodimerization activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005634 nucleus;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0045177 apical part of cell",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0009117 nucleotide metabolic process;GO:0046085 adenosine metabolic process;GO:0051930 regulation of sensory perception of pain;GO:0006144 purine nucleobase metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 11.0,
        "record_id": "P15309-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P23467-1",
        "uniprot_id": [
            {
                "id": "PTPRB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P23467",
                "type": "external"
            }
        ],
        "mass": 224301.0,
        "length": 1997,
        "protein_name": "Receptor-type tyrosine-protein phosphatase beta",
        "gene_name": "PTPRB",
        "organism": "Human",
        "refseq_name": "receptor-type tyrosine-protein phosphatase beta isoform a",
        "refseq_ac": [
            {
                "id": "NP_001103224",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001103224",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PTPRB; PTPB",
        "gene_names_refseq": "HPTP-BETA; HPTPB; PTPB; PTPRB; R-PTP-BETA; VEPTP",
        "protein_names_uniprotkb": "Receptor-type tyrosine-protein phosphatase beta; 3.1.3.48; Protein-tyrosine phosphatase beta; R-PTP-beta; VE-PTP; Vascular endothelial protein tyrosine phosphatase",
        "protein_names_refseq": "VE-PTP; protein tyrosine phosphatase, receptor type, beta polypeptide; receptor-type tyrosine-protein phosphatase beta isoform a; vascular endothelial protein tyrosine phosphatase",
        "tax_id": 9606,
        "disease": "angiosarcoma (Disease Ontology:DOID:0001816); brain glioma (Disease Ontology:DOID:0060108); colorectal carcinoma (Disease Ontology:DOID:0080199); sarcoma (Disease Ontology:DOID:1115); glioblastoma (Disease Ontology:DOID:3068); osteosarcoma (Disease Ontology:DOID:3347); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung non-small cell carcinoma (Disease Ontology:DOID:3908); lung adenocarcinoma (Disease Ontology:DOID:3910); thyroid gland carcinoma (Disease Ontology:DOID:3963); breast angiosarcoma (Disease Ontology:DOID:4511); hepatocellular carcinoma (Disease Ontology:DOID:684)",
        "pathway": " (hsa:5787);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 37,
        "publication_id_list": "11237011;15144186;16759857;17081983;17139078;18452278;19116766;19136612;19167335;19451274;2170109;22869525;23481700;23650620;25892735;27397612;27862975;28385807;28871256;29242379;29393594;29557506;31154438;31530632;31829261;31848261;32157095;32663515;32938616;33592498;35051231;35580925;36148623;36397361;37340703;37938771;8692836",
        "class_list": "",
        "function": "Novel rare mutation in a conserved site of PTPRB causes human hypoplastic left heart syndrome., [RefSeq, PubMed]; PSMD11, PTPRM and PTPRB as novel biomarkers of pancreatic cancer progression., [RefSeq, PubMed]; Plays an important role in blood vessel remodeling and angiogenesis. Not necessary for the initial formation of blood vessels, but is essential for their maintenance and remodeling. Can induce dephosphorylation of TEK/TIE2, CDH5/VE-cadherin and KDR/VEGFR-2. Regulates angiopoietin-TIE2 signaling in endothelial cells. Acts as a negative regulator of TIE2, and controls TIE2 driven endothelial cell proliferation, which in turn affects blood vessel remodeling during embryonic development and determines blood vessel size during perinatal growth. Essential for the maintenance of endothelial cell contact integrity and for the adhesive function of VE-cadherin in endothelial cells and this requires the presence of plakoglobin., [UniProtKB, UniProtKB, UniProtKB, PubMed, PubMed, PubMed]; Study found PTPRB negatively correlated with miR-624 expression in osteosarcoma (OS) tissues. PTPRB was confirmed as a downstream target of miR-624. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a member of the protein tyrosine phosphatase (PTP) family. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP contains an extracellular domain, a single transmembrane segment and one intracytoplasmic catalytic domain, thus belongs to receptor type PTP. The extracellular region of this PTP is composed of multiple fibronectin type_III repeats, which was shown to interact with neuronal receptor and cell adhesion molecules, such as contactin and tenascin C. This protein was also found to interact with sodium channels, and thus may regulate sodium channels by altering tyrosine phosphorylation status. The functions of the interaction partners of this protein implicate the roles of this PTP in cell adhesion, neurite growth, and neuronal differentiation. Alternate transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2011]., [RefSeq]; The variants in PTPRB, TRAF3IP3, and DISC1 genes were associated with Graves' disease in the Chinese population., [RefSeq, PubMed]",
        "predicted_glycosites": 27,
        "predicted_n_glycosites": 26,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 116,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "prognostic",
        "glycan_count": 1,
        "disease_count": 12,
        "glyco_site_count": 28,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7ZKS8;B7ZKT0;C9JX87;F5H3G6;Q14D85;Q3MIV7",
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                "id": "3.1.3.48",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.18",
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                "id": "1.2.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.5",
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                "url": "https://www.rhea-db.org/rhea/?query=ec:1.2.1.7",
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                "id": "1.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.-",
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                "id": "3.1.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4",
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                "id": "2.3.2.27",
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        "go_cellular_component": "GO:0005886 plasma membrane;GO:0035579 specific granule membrane;GO:0043235 receptor complex;GO:0070821 tertiary granule membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0016311 dephosphorylation;GO:0001525 angiogenesis;GO:0006796 phosphate-containing compound metabolic process;GO:0006470 protein dephosphorylation;GO:0001649 osteoblast differentiation",
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                "url": "https://www.uniprot.org/uniprot/Q6PJ21",
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        "mass": 39376.0,
        "length": 355,
        "protein_name": "SPRY domain-containing SOCS box protein 3",
        "gene_name": "SPSB3",
        "organism": "Human",
        "refseq_name": "SPRY domain-containing SOCS box protein 3",
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                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001311010",
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        "gene_names_refseq": "C16orf31; SPSB3; SSB3",
        "protein_names_uniprotkb": "SPRY domain-containing SOCS box protein 3; SSB-3",
        "protein_names_refseq": "SPRY domain-containing SOCS box protein 3; SPRY domain-containing SOCS box protein SSB-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:90864);  (R-HSA-8951664)",
        "pathway_count": 2,
        "publication_count": 153,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11069780;11237011;11259415;11292861;11292862;11454738;11585840;11733065;11961546;12101228;12186903;12504025;12504026;12526791;12538644;12609982;12682069;12759363;12816948;14690597;14757770;15282312;15361859;15367669;15537541;15572695;15574592;15601839;15652483;15688063;15694336;15713673;15799966;16171779;16401342;16547496;16647857;16707496;16790436;16943200;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18775313;18776931;18805092;18826954;18851830;18926707;19250909;19321346;19617556;19748355;20532202;21447816;21463634;21778237;21863050;21940857;22306028;22466964;22537386;22959436;23201271;23333871;23401859;23453757;23481700;23535662;23535663;23563313;23583660;23912815;23986495;24076655;24366543;24636985;24793695;24793696;25314029;25349211;25355947;25418920;25531226;25880248;26154972;26344709;26375851;26460955;26632597;26811146;26906416;26929215;26992070;27030794;27222660;27565346;27846572;27862975;28115426;28218747;28832583;28834231;28904123;29059170;29153394;29242379;29331515;29393594;29508533;29557506;29632046;30429286;30610225;30779550;31154438;31217245;31222486;31844290;31848261;32005965;32157095;32161166;32265295;32284348;32357974;32387766;32502341;32938616;32983136;33123756;33444648;33981976;34171305;34932366;35051231;35318648;35580925;38418882;9790970;9887101;9891082",
        "class_list": "",
        "function": "Observational study and genome-wide association study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; Substrate-recognition component of a cullin-5-RING E3 ubiquitin-protein ligase complex (ECS complex, also named CRL5 complex), which mediates the ubiquitination and subsequent proteasomal degradation of target proteins, such as CGAS and SNAI1 (PubMed:29059170, PubMed:38418882). The ECS(SPSB3) complex catalyzes 'Lys-48'-linked ubiquitination of nuclear CGAS in cycling cells, leading to its degradation (PubMed:38418882). Recognizes and binds nucleosome-bound CGAS: ubiquitination and degradation of nuclear CGAS during G1 and G2 phases is required to promote low intranuclear CGAS abundance before the next mitotic cycle (PubMed:38418882). The ECS(SPSB3) complex also mediates ubiquitination and degradation of phosphorylated SNAI1 (PubMed:29059170)., [UniProtKB, PubMed, PubMed]; The CRL5-SPSB3 ubiquitin ligase targets nuclear cGAS for degradation., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 2,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DU78;Q49A96;Q86X18;Q8WXK5;Q96IE6;Q96RY2",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex;GO:0031466 Cul5-RING ubiquitin ligase complex",
        "go_biological_process": "GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0070936 protein K48-linked ubiquitination;GO:0010719 negative regulation of epithelial to mesenchymal transition;GO:0160049 negative regulation of cGAS/STING signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 15.4,
        "record_id": "Q6PJ21-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O95980-1",
        "uniprot_id": [
            {
                "id": "RECK_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O95980",
                "type": "external"
            }
        ],
        "mass": 106457.0,
        "length": 971,
        "protein_name": "Reversion-inducing cysteine-rich protein with Kazal motifs",
        "gene_name": "RECK",
        "organism": "Human",
        "refseq_name": "reversion-inducing cysteine-rich protein with Kazal motifs isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_066934",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_066934",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "RECK; ST15",
        "gene_names_refseq": "RECK; ST15",
        "protein_names_uniprotkb": "Reversion-inducing cysteine-rich protein with Kazal motifs; Suppressor of tumorigenicity 15 protein; hRECK",
        "protein_names_refseq": "membrane-anchored glycoprotein (metastasis and invasion); reversion-inducing cysteine-rich protein with Kazal motifs isoform 1 precursor; reversion-inducing cysteine-rich protein with Kazal motifs; suppression of tumorigenicity 15 (reversion-inducing-cysteine-rich protein with kazal motifs); suppression of tumorigenicity 5 (reversion-inducing-cysteine-rich protein with kazal motifs); suppressor of tumorigenicity 15 protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:8434);  (R-HSA-163125)",
        "pathway_count": 2,
        "publication_count": 36,
        "publication_id_list": "10.1101/2023.09.13.557529;11072085;12438739;12738734;16103099;18194466;23090970;24190977;2443973;25418920;25576301;25880248;28289266;29557506;30026314;30429286;30459171;31844290;32157095;32350084;32938616;33592498;33731436;3422494;34357683;34405274;35051231;35561310;35941073;36284347;36585230;37904179;38387446;38665916;38686051;9789069",
        "class_list": "",
        "function": "Association between the Reduced Expression of RECK and Neutrophilic Inflammation in Chronic Obstructive Pulmonary Disease., [RefSeq, PubMed]; Four SNPs were identified in the coding region of the gene (exons 1, 9, 13 and 15), and the remaining nine in introns 5, 8, 10, 12, 15 and 17., [RefSeq, PubMed]; Functions together with ADGRA2 to enable brain endothelial cells to selectively respond to Wnt7 signals (WNT7A or WNT7B) (PubMed:28289266, PubMed:30026314). Plays a key role in Wnt7-specific responses: required for central nervous system (CNS) angiogenesis and blood-brain barrier regulation (By similarity). Acts as a Wnt7-specific coactivator of canonical Wnt signaling by decoding Wnt ligands: acts by interacting specifically with the disordered linker region of Wnt7, thereby conferring ligand selectivity for Wnt7 (PubMed:30026314). ADGRA2 is then required to deliver RECK-bound Wnt7 to frizzled by assembling a higher-order RECK-ADGRA2-Fzd-LRP5-LRP6 complex (PubMed:30026314). Also acts as a serine protease inhibitor: negatively regulates matrix metalloproteinase-9 (MMP9) by suppressing MMP9 secretion and by direct inhibition of its enzymatic activity (PubMed:18194466, PubMed:9789069). Also inhibits metalloproteinase activity of MMP2, MMP14 (MT1-MMP) and ADAM10 (PubMed:9789069, PubMed:33731436)., [UniProtKB, PubMed, PubMed, PubMed, UniProtKB, PubMed, PubMed]; High RECK protein is associated with invasiveness of pancreatic cancer by MMP-2 activation, [RefSeq, PubMed]; Identification of RECK as a protective prognostic indicator and a tumor suppressor through regulation of the ERK/MAPK signaling pathway in gastric cancer. Publication Status: Online-Only, [RefSeq, PubMed]; MiR-200b-3p accelerates progression of pituitary adenomas by negatively regulating expression of RECK. Publication Status: Online-Only, [RefSeq, PubMed]; RECK gene polymorphisms in hepatitis B-related hepatocellular carcinoma: A case-control study., [RefSeq, PubMed]; The protein encoded by this gene is a cysteine-rich, extracellular protein with protease inhibitor-like domains whose expression is suppressed strongly in many tumors and cells transformed by various kinds of oncogenes. In normal cells, this membrane-anchored glycoprotein may serve as a negative regulator for matrix metalloproteinase-9, a key enzyme involved in tumor invasion and metastasis. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2015]., [RefSeq]; [miR-181c promotes the migration and angiogenesis of human A549 cells via targeting inhibition of reversion-inducing cysteine-rich protein with Kazal motifs (RECK)]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 5,
        "mined_n_glycosites": 5,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 0,
        "glyco_site_count": 6,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNS1;Q5W0K6;Q8WX37",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0015026 coreceptor activity;GO:0004866 endopeptidase inhibitor activity;GO:0017147 Wnt-protein binding;GO:0008191 metalloendopeptidase inhibitor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005886 plasma membrane;GO:0016020 membrane;GO:1990909 Wnt signalosome;GO:0098552 side of membrane",
        "go_biological_process": "GO:0030198 extracellular matrix organization;GO:0030336 negative regulation of cell migration;GO:1903053 regulation of extracellular matrix organization;GO:0001955 blood vessel maturation;GO:0060070 canonical Wnt signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 4.7,
        "record_id": "O95980-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.010000.000000000001000000.1100100000000.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q99944-1",
        "uniprot_id": [
            {
                "id": "EGFL8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q99944",
                "type": "external"
            }
        ],
        "mass": 32262.0,
        "length": 293,
        "protein_name": "Epidermal growth factor-like protein 8",
        "gene_name": "EGFL8",
        "organism": "Human",
        "refseq_name": "epidermal growth factor-like protein 8 precursor",
        "refseq_ac": [
            {
                "id": "NP_085155",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_085155",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EGFL8; C6orf8; NG3; PRO29920",
        "gene_names_refseq": "C6orf8; EGFL8; NG3",
        "protein_names_uniprotkb": "Epidermal growth factor-like protein 8; EGF-like protein 8; VE-statin-2; Vascular endothelial statin-2",
        "protein_names_refseq": "EGF-like protein 8; VE-statin-2; epidermal growth factor-like protein 8 precursor; epidermal growth factor-like protein 8; vascular endothelial statin-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:80864)",
        "pathway_count": 1,
        "publication_count": 13,
        "publication_id_list": "11237011;12975309;14656967;15340161;19143814;19851445;20587610;22898188;33712610;34130659;34411563;34626176;35580925",
        "class_list": "",
        "function": "Down-regulation of EGFL8 regulates migration, invasion and apoptosis of hepatocellular carcinoma through activating Notch signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed, PubMed]; Schwann cell plasticity regulates neuroblastic tumor cell differentiation via epidermal growth factor-like protein 8. Publication Status: Online-Only, [RefSeq, PubMed]; Whole-exome sequencing reveals a role of HTRA1 and EGFL8 in brain white matter hyperintensities., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 11,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0S884;G5E9Q0;Q5JP23;Q5SSX3;Q8IV30",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0009986 cell surface",
        "go_biological_process": "GO:0001570 vasculogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 1.6,
        "record_id": "Q99944-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P22413-1",
        "uniprot_id": [
            {
                "id": "ENPP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P22413",
                "type": "external"
            }
        ],
        "mass": 104924.0,
        "length": 925,
        "protein_name": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 1",
        "gene_name": "ENPP1",
        "organism": "Human",
        "refseq_name": "ectonucleotide pyrophosphatase/phosphodiesterase family member 1",
        "refseq_ac": [
            {
                "id": "NP_006199",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006199",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ENPP1; M6S1; NPPS; PC1; PDNP1",
        "gene_names_refseq": "ARHR2; COLED; ENPP1; M6S1; NPP1; NPPS; PC-1; PCA1; PDNP1",
        "protein_names_uniprotkb": "Ectonucleotide pyrophosphatase/phosphodiesterase family member 1; 3.1.4.1; 3.6.1.9; Alkaline phosphodiesterase I; E-NPP 1; Membrane component chromosome 6 surface marker 1; NPPase; Nucleotide diphosphatase; Nucleotide pyrophosphatase; Phosphodiesterase I/nucleotide pyrophosphatase 1; Plasma-cell membrane glycoprotein PC-1",
        "protein_names_refseq": "E-NPP 1; Ly-41 antigen; NPPase; alkaline phosphodiesterase 1; alkaline phosphodiesterase I; ectonucleotide pyrophosphatase/phosphodiesterase family member 1; membrane component, chromosome 6, surface marker 1; nucleotide diphosphatase; phosphodiesterase I/nucleotide pyrophosphatase 1; plasma-cell membrane glycoprotein 1; plasma-cell membrane glycoprotein PC-1",
        "tax_id": 9606,
        "disease": "arterial calcification of infancy (Disease Ontology:DOID:0050644); autosomal recessive hypophosphatemic rickets (Disease Ontology:DOID:0050949); stroke (Disease Ontology:DOID:0051061); ossification of the posterior longitudinal ligament of spine (Disease Ontology:DOID:0060887); aortic valve disease 1 (Disease Ontology:DOID:0080333); otitis media (Disease Ontology:DOID:10754); spondyloarthropathy (Disease Ontology:DOID:1123); tympanosclerosis (Disease Ontology:DOID:1214); cardiovascular system disease (Disease Ontology:DOID:1287); pseudoxanthoma elasticum (Disease Ontology:DOID:2738); glioblastoma (Disease Ontology:DOID:3068); end stage renal disease (Disease Ontology:DOID:783); osteoarthritis (Disease Ontology:DOID:8398); type 2 diabetes mellitus (Disease Ontology:DOID:9352); obesity (Disease Ontology:DOID:9970); hypopigmentation-punctate palmoplantar keratoderma syndrome (MONDO:MONDO:0014227)",
        "pathway": " (hsa:5167);  (R-HSA-196843);  (R-HSA-199220)",
        "pathway_count": 3,
        "publication_count": 80,
        "publication_id_list": "10.1101/2023.09.13.557529;10329687;10334869;10453738;10480624;10567687;10615944;11004006;11158296;11237011;11598187;12623014;12757929;12815048;12881724;1315502;15072822;15605415;15940697;16186408;16643857;17242360;18632736;19159218;19349973;19429682;20016754;20034067;20137772;20137773;20206331;20463145;21110228;21183659;2211644;22209248;23090970;23301498;23430823;24075184;24190977;24264046;25344812;25576301;25741938;25892735;26617416;27322068;27467858;27600516;2775236;28011303;28964717;29741879;29769354;29958952;30833945;31004344;31844290;32157095;32234503;32395117;32938616;33592498;33968037;34171305;35051231;35147247;36010968;36983025;37074911;38265511;38498770;38582229;38806089;7737162;8001561;8934567;9344668;9516450",
        "class_list": "",
        "function": "ENPP1 inhibits the transcription activity of the hepatitis B virus pregenomic promoter by upregulating the acetylation of LMNB1. Publication Status: Online-Only, [RefSeq, PubMed]; Nucleotide pyrophosphatase that generates diphosphate (PPi) and functions in bone mineralization and soft tissue calcification by regulating pyrophosphate levels (By similarity). PPi inhibits bone mineralization and soft tissue calcification by binding to nascent hydroxyapatite crystals, thereby preventing further growth of these crystals (PubMed:11004006). Preferentially hydrolyzes ATP, but can also hydrolyze other nucleoside 5' triphosphates such as GTP, CTP and UTP to their corresponding monophosphates with release of pyrophosphate, as well as diadenosine polyphosphates, and also 3',5'-cAMP to AMP (PubMed:25344812, PubMed:27467858, PubMed:28011303, PubMed:35147247, PubMed:8001561). May also be involved in the regulation of the availability of nucleotide sugars in the endoplasmic reticulum and Golgi, and the regulation of purinergic signaling (PubMed:27467858, PubMed:8001561). Inhibits ectopic joint calcification and maintains articular chondrocytes by repressing hedgehog signaling; it is however unclear whether hedgehog inhibition is direct or indirect (By similarity). Appears to modulate insulin sensitivity and function (PubMed:10615944). Also involved in melanogenesis (PubMed:28964717). Also able to hydrolyze 2',3'-cGAMP (cyclic GMP-AMP), a second messenger that activates TMEM173/STING and triggers type-I interferon production (PubMed:25344812). 2',3'-cGAMP degradation takes place in the lumen or extracellular space, and not in the cytosol where it is produced; the role of 2',3'-cGAMP hydrolysis is therefore unclear (PubMed:25344812). Not able to hydrolyze the 2',3'-cGAMP linkage isomer 3'-3'-cGAMP (PubMed:25344812)., [UniProtKB, PubMed, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Quantitative correlation of ENPP1 pathogenic variants with disease phenotype., [RefSeq, PubMed]; TET3 boosts hepatocyte autophagy and impairs non-alcoholic fatty liver disease by increasing ENPP1 promoter hypomethylation., [RefSeq, PubMed]; This gene is a member of the ecto-nucleotide pyrophosphatase/phosphodiesterase (ENPP) family. The encoded protein is a type II transmembrane glycoprotein comprising two identical disulfide-bonded subunits. This protein has broad specificity and cleaves a variety of substrates, including phosphodiester bonds of nucleotides and nucleotide sugars and pyrophosphate bonds of nucleotides and nucleotide sugars. This protein may function to hydrolyze nucleoside 5' triphosphates to their corresponding monophosphates and may also hydrolyze diadenosine polyphosphates. Mutations in this gene have been associated with 'idiopathic' infantile arterial calcification, ossification of the posterior longitudinal ligament of the spine (OPLL), and insulin resistance. [provided by RefSeq, Jul 2008]., [RefSeq]; Tumor Exosomal ENPP1 Hydrolyzes cGAMP to Inhibit cGAS-STING Signaling., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 9,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 9,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 10,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 10,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 47,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 45,
        "disease_count": 16,
        "glyco_site_count": 10,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T9R6;Q9NPZ3;Q9P1P6;Q9UP61;Q9Y6K3",
        "ec_number_list": [
            {
                "id": "3.1.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.-",
                "type": "external"
            },
            {
                "id": "3.1.4.17",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.17",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.1.4.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.1",
                "type": "external"
            },
            {
                "id": "3.6.1.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.9",
                "type": "external"
            },
            {
                "id": "3.1.4.53",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.53",
                "type": "external"
            },
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "3.6.1.59",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.59",
                "type": "external"
            },
            {
                "id": "3.6.1.52",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.52",
                "type": "external"
            },
            {
                "id": "3.6.1.62",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.62",
                "type": "external"
            },
            {
                "id": "3.6.1.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.10",
                "type": "external"
            },
            {
                "id": "3.6.1.61",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.61",
                "type": "external"
            },
            {
                "id": "3.1.4.39",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.39",
                "type": "external"
            },
            {
                "id": "3.1.4.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.4",
                "type": "external"
            },
            {
                "id": "3.6.1.25",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.25",
                "type": "external"
            },
            {
                "id": "3.6.1.14",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.14",
                "type": "external"
            },
            {
                "id": "3.1.4.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.4.35",
                "type": "external"
            },
            {
                "id": "3.6.1.68",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.68",
                "type": "external"
            },
            {
                "id": "3.6.1.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.76",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0030247 polysaccharide binding;GO:0050656 3'-phosphoadenosine 5'-phosphosulfate binding;GO:0005044 scavenger receptor activity;GO:0005158 insulin receptor binding;GO:0005524 ATP binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0016323 basolateral plasma membrane",
        "go_biological_process": "GO:0046627 negative regulation of insulin receptor signaling pathway;GO:0006091 generation of precursor metabolites and energy;GO:0006955 immune response;GO:0032869 cellular response to insulin stimulus;GO:0006796 phosphate-containing compound metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 13.7,
        "record_id": "P22413-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9UKW6-1",
        "uniprot_id": [
            {
                "id": "ELF5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9UKW6",
                "type": "external"
            }
        ],
        "mass": 31263.0,
        "length": 265,
        "protein_name": "ETS-related transcription factor Elf-5",
        "gene_name": "ELF5",
        "organism": "Human",
        "refseq_name": "ETS-related transcription factor Elf-5 isoform 3",
        "refseq_ac": [
            {
                "id": "NP_001230009",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001230009",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ELF5; ESE2",
        "gene_names_refseq": "ELF5; ESE2",
        "protein_names_uniprotkb": "ETS-related transcription factor Elf-5; E74-like factor 5; ESE-2; Epithelium-restricted ESE-1-related Ets factor; Epithelium-specific Ets transcription factor 2",
        "protein_names_refseq": "E74-like factor 5 (ets domain transcription factor); ETS-related transcription factor Elf-5 isoform 3; ETS-related transcription factor Elf-5; epithelium-restricted ESE-1-related Ets factor; epithelium-specific Ets transcription factor 2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2001);  (R-HSA-9927418);  (R-HSA-9927426)",
        "pathway_count": 3,
        "publication_count": 9,
        "publication_id_list": "10506207;11237011;12359648;29331515;29786170;34140348;34146197;35970849;9840936",
        "class_list": "",
        "function": "Breast-Specific Molecular Clocks Comprised of ELF5 Expression and Promoter Methylation Identify Individuals Susceptible to Cancer Initiation., [RefSeq, PubMed]; ELF5 inhibits the proliferation and invasion of breast cancer cells by regulating CD24., [RefSeq, PubMed]; ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19. Publication Status: Online-Only, [RefSeq, PubMed]; Isoform 2 binds to DNA sequences containing the consensus nucleotide core sequence GGA[AT]. Transcriptionally activates SPRR2A and the parotid gland-specific PSP promoters., [UniProtKB, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; This gene encodes an epithelium-specific ETS family transcription factor. In addition to its role in regulating the later stages of terminal differentiation of keratinocytes, it appears to regulate a number of epithelium-specific genes found in tissues containing glandular epithelium such as salivary gland and prostate. It has very low affinity to DNA due to its negative regulatory domain at the amino terminus. This gene has been implicated as a tumor suppressive transcription factor in breast cancer. [provided by RefSeq, May 2022]., [RefSeq]; Transcriptionally activator that may play a role in regulating the later stages of keratinocytes terminal differentiation., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6XAE6;A8K452;O95175;Q8N2K9;Q96QY3;Q9UKW5",
        "ec_number_list": [],
        "go_molecular_function": "GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific;GO:0001228 DNA-binding transcription activator activity, RNA polymerase II-specific;GO:1990837 sequence-specific double-stranded DNA binding;GO:0003700 DNA-binding transcription factor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "Q9UKW6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q86X60-1",
        "uniprot_id": [
            {
                "id": "FA72B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q86X60",
                "type": "external"
            }
        ],
        "mass": 16617.0,
        "length": 149,
        "protein_name": "Protein FAM72B",
        "gene_name": "FAM72B",
        "organism": "Human",
        "refseq_name": "protein FAM72B isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001094380",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001094380",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM72B",
        "gene_names_refseq": "FAM72B; p17",
        "protein_names_uniprotkb": "Protein FAM72B",
        "protein_names_refseq": "RP11-439A17.6; amyloid-beta peptide-induced protein p17; protein FAM72B isoform 1; protein FAM72B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:653820)",
        "pathway_count": 1,
        "publication_count": 7,
        "publication_id_list": "11237011;19755123;22424782;26206078;29557506;32502341;33141586",
        "class_list": "",
        "function": "An epistemological characterization of the human tumorigenic neuronal paralogous FAM72 gene loci (FAM72A, FAM72B, FAM72C, FAM72D)., [RefSeq, PubMed]; This study provides an additional possible mechanism of neurotoxicity in Alzheimer's disease, the induction of p17(FAM72B), through which Abeta acts to induce apoptosis and exhibit other Alzheimer's disease characteristics., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RPQ5;Q5QP15",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.8,
        "record_id": "Q86X60-1",
        "record_type": "protein",
        "filter_code": "0000000.0000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NZ08-1",
        "uniprot_id": [
            {
                "id": "ERAP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NZ08",
                "type": "external"
            }
        ],
        "mass": 107235.0,
        "length": 941,
        "protein_name": "Endoplasmic reticulum aminopeptidase 1",
        "gene_name": "ERAP1",
        "organism": "Human",
        "refseq_name": "endoplasmic reticulum aminopeptidase 1 isoform b precursor",
        "refseq_ac": [
            {
                "id": "NP_001035548",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035548",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ERAP1; APPILS; ARTS1; KIAA0525; PRO1154",
        "gene_names_refseq": "A-LAP; ALAP; APPILS; ARTS-1; ARTS1; ERAAP1; ERAAP; ERAP1; PILS-AP; PILSAP",
        "protein_names_uniprotkb": "Endoplasmic reticulum aminopeptidase 1; 3.4.11.-; A-LAP; ARTS-1; Adipocyte-derived leucine aminopeptidase; Aminopeptidase PILS; PILS-AP; Puromycin-insensitive leucyl-specific aminopeptidase; Type 1 tumor necrosis factor receptor shedding aminopeptidase regulator",
        "protein_names_refseq": "adipocyte-derived leucine aminopeptidase; aminopeptidase PILS; aminopeptidase regulator of TNFR1 shedding; endoplasmic reticulum aminopeptidase 1 isoform b precursor; endoplasmic reticulum aminopeptidase associated with antigen processing; puromycin-insensitive leucyl-specific aminopeptidase; type 1 tumor necrosis factor receptor shedding aminopeptidase regulator",
        "tax_id": 9606,
        "disease": "severe pre-eclampsia (Disease Ontology:DOID:13129); endometrial carcinoma (Disease Ontology:DOID:2871); cervix carcinoma (Disease Ontology:DOID:2893)",
        "pathway": " (hsa:51752);  (R-HSA-983170)",
        "pathway_count": 2,
        "publication_count": 132,
        "publication_id_list": "10.1101/2023.09.13.557529;10064069;10220586;10600378;10777614;10825291;10982397;11056387;11160214;11163199;11237011;11481040;11514579;11857741;12189246;12436109;12436110;12645939;12975309;14681859;14718384;15286279;15908954;15927284;16286653;16465444;16473882;17056546;17088086;17316621;17656363;18445477;19119025;19159218;19193869;19261456;19342655;19361863;19426129;19575639;19851281;20068231;2038058;20605430;21050182;21478864;24190977;24366607;24397554;2450918;24715725;25502872;25576301;25589627;26154972;26992070;27397612;27862975;27920218;28218747;28228285;28446606;28467828;28510447;28832583;28904123;29242379;29393594;29437277;29493099;29557506;29632711;29741879;29786170;29789417;30315122;30410026;30429286;30573663;31092671;31611695;31844290;32157095;32350084;32357974;32387766;32488085;32502341;32897882;32938616;32983136;33043033;33141586;33298915;33392160;33592498;33633747;33691108;33717175;33912179;33936100;33968037;34171305;34211107;34357683;34433824;34509645;34725712;34932366;35051231;35154160;35251023;35318648;35580925;36010968;36241641;36284347;37074911;37925533;37938771;38253038;38342012;38551779;38665916;38951078;39034571;39302247;40914422;7642652;7876241;8342042;9605141",
        "class_list": "",
        "function": "ARTS-1 has been identified as a novel TNFR1 binding protein that promotes TNFR1 shedding., [RefSeq, PubMed]; Aminopeptidase that plays a central role in peptide trimming, a step required for the generation of most HLA class I-binding peptides. Peptide trimming is essential to customize longer precursor peptides to fit them to the correct length required for presentation on MHC class I molecules. Strongly prefers substrates 9-16 residues long. Rapidly degrades 13-mer to a 9-mer and then stops. Preferentially hydrolyzes the residue Leu and peptides with a hydrophobic C-terminus, while it has weak activity toward peptides with charged C-terminus. May play a role in the inactivation of peptide hormones. May be involved in the regulation of blood pressure through the inactivation of angiotensin II and/or the generation of bradykinin in the kidney., [UniProtKB, PubMed, PubMed, PubMed]; Association has been confirmed between the Lys528Arg polymorphism of the adipocyte-derived leucine aminopeptidase gene and essential hypertension., [RefSeq, PubMed]; Association of Endoplasmic Reticulum Aminopeptidase 1 Gene Polymorphism with Susceptibility and Severity of Axial Spondyloarthritis in Egyptian Population: A Single-center Case-Control Study., [RefSeq, PubMed]; Association of a single nucleotide polymorphism (rs27434) in the ERAP1 gene with plural tissue weight., [RefSeq, PubMed]; Evolutionary immuno-genetics of endoplasmic reticulum aminopeptidase II (ERAP2). Review article, [RefSeq, PubMed]; Role of endoplasmic reticulum aminopeptidase-1 gene polymorphism (rs13167972) in occurrence susceptibility of ankylosing spondylitis in a sample of Iraqi male patients. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is an aminopeptidase involved in trimming HLA class I-binding precursors so that they can be presented on MHC class I molecules. The encoded protein acts as a monomer or as a heterodimer with ERAP2. This protein may also be involved in blood pressure regulation by inactivation of angiotensin II. Three transcript variants encoding two different isoforms have been found for this gene.[provided by RefSeq, Oct 2010]., [RefSeq]; [Relationship between maternal and fetal ERAP-1 gene polymorphism and pre-eclampsia]., [RefSeq, PubMed]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 41,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 34,
        "disease_count": 3,
        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O60278;Q6UWY6;Q8NEL4;Q8TAD0;Q9UHF8;Q9UKY2",
        "ec_number_list": [
            {
                "id": "3.4.11.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.11.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004175 endopeptidase activity;GO:0008270 zinc ion binding;GO:0004177 aminopeptidase activity;GO:0008235 metalloexopeptidase activity;GO:0070006 metalloaminopeptidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0006508 proteolysis;GO:0006509 membrane protein ectodomain proteolysis;GO:0008217 regulation of blood pressure;GO:0043171 peptide catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 17.4,
        "record_id": "Q9NZ08-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000011001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q16621-1",
        "uniprot_id": [
            {
                "id": "NFE2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q16621",
                "type": "external"
            }
        ],
        "mass": 41473.0,
        "length": 373,
        "protein_name": "Transcription factor NF-E2 45 kDa subunit",
        "gene_name": "NFE2",
        "organism": "Human",
        "refseq_name": "transcription factor NF-E2 45 kDa subunit isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001129495",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001129495",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "NFE2",
        "gene_names_refseq": "NF-E2; NFE2; p45",
        "protein_names_uniprotkb": "Transcription factor NF-E2 45 kDa subunit; Leucine zipper protein NF-E2; Nuclear factor, erythroid-derived 2 45 kDa subunit; p45 NF-E2",
        "protein_names_refseq": "leucine zipper protein NF-E2; nuclear factor (erythroid-derived 2), 45kDa; nuclear factor, erythroid-derived 2 45 kDa subunit; transcription factor NF-E2 45 kDa subunit isoform 1; transcription factor NF-E2 45 kDa subunit",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:4778);  (R-HSA-8936459);  (R-HSA-983231)",
        "pathway_count": 3,
        "publication_count": 74,
        "publication_id_list": "10617663;11042108;11062261;11154691;11237011;11242053;11744692;11751636;11895428;11950885;12032298;12134158;12427746;12483298;12576332;15020713;15247287;15710388;16054028;16287851;1630448;16628190;17027967;17196961;18316480;18718448;19114653;19293402;19509293;20339092;20530532;20627800;20876458;21129147;21252065;21725049;218813;22777353;26010396;26154972;26845023;26992070;27862975;28314751;28832583;29393594;29485866;29493099;29557506;29605689;30429286;31154438;31844290;32593231;32593672;32983136;33392160;33945619;3409321;34559205;35051231;35580925;39894887;7724591;8248255;8355703;8662638;8816476;9065479;9230307;9326583;9331217;9422515;9927674",
        "class_list": "",
        "function": "Component of the NF-E2 complex essential for regulating erythroid and megakaryocytic maturation and differentiation. Binds to the hypersensitive site 2 (HS2) of the beta-globin control region (LCR). This subunit (NFE2) recognizes the TCAT/C sequence of the AP-1-like core palindrome present in a number of erythroid and megakaryocytic gene promoters. Requires MAFK or other small MAF proteins for binding to the NF-E2 motif. May play a role in all aspects of hemoglobin production from globin and heme synthesis to procurement of iron., [UniProtKB, PubMed, PubMed]; Impact of NFE2 mutations on AML transformation and overall survival in patients with myeloproliferative neoplasms., [RefSeq, PubMed]; In a multi-institutional cohort of myeloid sarcomas, NFE2 mutation prevalence is lower than previously reported., [RefSeq, PubMed]; Nuclear factor erythroid 2 (NF-E2) p45-related factor 2 interferes with homeodomain-interacting protein kinase 2/p53 activity to impair solid tumors chemosensitivity., [RefSeq, PubMed]; The transcription factor NFE2 enhances expression of the hematopoietic master regulators SCL/TAL1 and GATA2., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 2,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 15,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q07720;Q6ICV9",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0003700 DNA-binding transcription factor activity;GO:0042802 identical protein binding;GO:0050699 WW domain binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0016605 PML body;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0045893 positive regulation of DNA-templated transcription;GO:0007599 hemostasis;GO:0006337 nucleosome disassembly",
        "synthesized_glycan_count": 0,
        "hit_score": 7.8,
        "record_id": "Q16621-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O15015-2",
        "uniprot_id": [
            {
                "id": "ZN646_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O15015",
                "type": "external"
            }
        ],
        "mass": 200825.0,
        "length": 1832,
        "protein_name": "Zinc finger protein 646",
        "gene_name": "ZNF646",
        "organism": "Human",
        "refseq_name": "zinc finger protein 646",
        "refseq_ac": [
            {
                "id": "NP_055514",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_055514",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ZNF646; KIAA0296",
        "gene_names_refseq": "ZNF646",
        "protein_names_uniprotkb": "Zinc finger protein 646",
        "protein_names_refseq": "zinc finger protein 646",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9726)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "16959974;17081983;18452278;23186163;23481700;25218447;25576301;25755297;25772364;28832583;29242379;29557506;29632711;29786170;30379171;30833945;31492838;31530632;31844290;32502341;32938616;33298915;33392160;33968037;35051231",
        "class_list": "",
        "function": "May be involved in transcriptional regulation., [UniProtKB]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 2,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 3,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 60,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IVD8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008270 zinc ion binding;GO:0000978 RNA polymerase II cis-regulatory region sequence-specific DNA binding;GO:0000981 DNA-binding transcription factor activity, RNA polymerase II-specific",
        "go_cellular_component": "GO:0005634 nucleus",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006355 regulation of DNA-templated transcription",
        "synthesized_glycan_count": 0,
        "hit_score": 2.9,
        "record_id": "O15015-2",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000001001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O75367-2",
        "uniprot_id": [
            {
                "id": "H2AY_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O75367",
                "type": "external"
            }
        ],
        "mass": 39184.0,
        "length": 369,
        "protein_name": "Core histone macro-H2A.1",
        "gene_name": "MACROH2A1",
        "organism": "Human",
        "refseq_name": "core histone macro-H2A.1 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001035248",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001035248",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "MACROH2A1; H2AFY",
        "gene_names_refseq": "H2A.y; H2A/y; H2AF12M; H2AFY; MACROH2A1.1; MACROH2A1; mH2A1; macroH2A1.2",
        "protein_names_uniprotkb": "Core histone macro-H2A.1; H2A/y; Histone H2A.y; Histone macroH2A1; Medulloblastoma antigen MU-MB-50.205; mH2A1",
        "protein_names_refseq": "H2A histone family member Y; core histone macro-H2A.1 isoform 2; core histone macro-H2A.1; histone H2A.y; histone macroH2A1.1; histone macroH2A1.2; medulloblastoma antigen MU-MB-50.205",
        "tax_id": 9606,
        "disease": "myelodysplastic syndrome (Disease Ontology:DOID:0050908)",
        "pathway": " (hsa:9555)",
        "pathway_count": 1,
        "publication_count": 70,
        "publication_id_list": "12718888;12800201;15621527;15897469;15902274;15965484;16107708;16129414;16210244;16428466;17081983;17924679;18077418;18227505;18446792;18452278;18669648;19007248;19413330;19651622;19690332;19691289;19818708;20068230;20068231;21211722;21406692;23022728;23186163;23474714;26552660;27452731;27543614;27600516;28218747;28228285;28514659;28832583;29242379;29314611;29351928;29393594;29508533;29632711;29786170;29789417;29905837;30192525;30315122;30524438;32119511;33043033;33214551;34019948;34185709;34725712;35083852;35511867;36215666;36284347;37852977;37938771;38665916;38990716;39255035;40596516;40914422;9634239;9653160;9714746",
        "class_list": "",
        "function": "Epigenetic regulation of cell state by H2AFY governs immunogenicity in high-risk neuroblastoma. Publication Status: Online-Only, [RefSeq, PubMed]; Histone Variant macroH2A1.1 Enhances Nonhomologous End Joining-dependent DNA Double-strand-break Repair and Reprogramming Efficiency of Human iPSCs., [RefSeq, PubMed]; Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene encodes a replication-independent histone that is a member of the histone H2A family. It replaces conventional H2A histones in a subset of nucleosomes where it represses transcription and participates in stable X chromosome inactivation. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Oct 2015]., [RefSeq]; In contrast to isoform 1, does not bind poly-ADP-ribose (PubMed:15902274). Represses SOD3 gene expression (PubMed:23022728)., [UniProtKB, PubMed, PubMed]; Isoform that specifically binds poly-ADP-ribose and O-acetyl-ADP-ribose and plays a key role in NAD(+) metabolism (PubMed:15902274). Able to bind to the ends of poly-ADP-ribose chains created by PARP1 and cap them (By similarity). This prevents PARP1 from further addition of ADP-ribose and thus limits the consumption of nuclear NAD(+), allowing the cell to maintain proper NAD(+) levels in both the nucleus and the mitochondria to promote proper mitochondrial respiration (By similarity). Increases the expression of genes involved in redox metabolism, including SOD3 (PubMed:23022728)., [UniProtKB, UniProtKB, PubMed, PubMed]; MacroH2A1 drives nucleosome dephasing and genome instability in histone humanized yeast., [RefSeq, PubMed]; MacroH2A1.1 as a crossroad between epigenetics, inflammation and metabolism of mesenchymal stromal cells in myelodysplastic syndromes. Publication Status: Online-Only, [RefSeq, PubMed]; Variant histone H2A which replaces conventional H2A in a subset of nucleosomes where it represses transcription (PubMed:12718888, PubMed:15621527, PubMed:16428466). Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template (PubMed:15897469). Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability (PubMed:15897469). DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Involved in stable X chromosome inactivation (PubMed:15897469). Inhibits the binding of transcription factors, including NF-kappa-B, and interferes with the activity of remodeling SWI/SNF complexes (PubMed:12718888, PubMed:16428466). Inhibits histone acetylation by EP300 and recruits class I HDACs, which induces a hypoacetylated state of chromatin (PubMed:16107708, PubMed:16428466)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 8,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O75377;Q503A8;Q7Z5E3;Q96D41;Q9H8P3;Q9UP96",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003677 DNA binding;GO:0019899 enzyme binding;GO:0019901 protein kinase binding;GO:0046982 protein heterodimerization activity;GO:0000977 RNA polymerase II transcription regulatory region sequence-specific DNA binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0070062 extracellular exosome;GO:0000793 condensed chromosome",
        "go_biological_process": "GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0019216 regulation of lipid metabolic process;GO:1902884 positive regulation of response to oxidative stress;GO:0045815 transcription initiation-coupled chromatin remodeling",
        "synthesized_glycan_count": 0,
        "hit_score": 7.4,
        "record_id": "O75367-2",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P23458-1",
        "uniprot_id": [
            {
                "id": "JAK1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P23458",
                "type": "external"
            }
        ],
        "mass": 133277.0,
        "length": 1154,
        "protein_name": "Tyrosine-protein kinase JAK1",
        "gene_name": "JAK1",
        "organism": "Human",
        "refseq_name": "tyrosine-protein kinase JAK1 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001307852",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001307852",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "JAK1; JAK1A; JAK1B",
        "gene_names_refseq": "AIIDE; JAK1A; JAK1B; JAK1; JTK3",
        "protein_names_uniprotkb": "Tyrosine-protein kinase JAK1; 2.7.10.2; JAK-1; Janus kinase 1",
        "protein_names_refseq": "tyrosine-protein kinase JAK1 isoform 1; tyrosine-protein kinase JAK1",
        "tax_id": 9606,
        "disease": "prostate cancer (Disease Ontology:DOID:10283); stomach cancer (Disease Ontology:DOID:10534); sciatic neuropathy (Disease Ontology:DOID:11446); endometrial cancer (Disease Ontology:DOID:1380); disease of cellular proliferation (Disease Ontology:DOID:14566); cancer (Disease Ontology:DOID:162); transient cerebral ischemia (Disease Ontology:DOID:224); ovarian cancer (Disease Ontology:DOID:2394); hematologic cancer (Disease Ontology:DOID:2531); pancreatic ductal adenocarcinoma (Disease Ontology:DOID:3498); lung non-small cell carcinoma (Disease Ontology:DOID:3908); pancreatic adenocarcinoma (Disease Ontology:DOID:4074); T-cell acute lymphoblastic leukemia (Disease Ontology:DOID:5603); hepatocellular carcinoma (Disease Ontology:DOID:684); systemic lupus erythematosus (Disease Ontology:DOID:9074); colorectal cancer (Disease Ontology:DOID:9256); autoinflammation, immune dysregulation, and eosinophilia (MONDO:MONDO:0033558)",
        "pathway": " (hsa:3716);  (R-HSA-1059683);  (R-HSA-110056);  (R-HSA-112411);  (R-HSA-1169408);  (R-HSA-1266695);  (R-HSA-449836);  (R-HSA-5673001);  (R-HSA-5684996);  (R-HSA-6783783);  (R-HSA-6785807);  (R-HSA-6788467);  (R-HSA-877300);  (R-HSA-877312);  (R-HSA-8854691);  (R-HSA-8983432);  (R-HSA-8984722);  (R-HSA-8985947);  (R-HSA-9020558);  (R-HSA-9020591);  (R-HSA-9020956);  (R-HSA-9020958);  (R-HSA-909733);  (R-HSA-912526);  (R-HSA-912694);  (R-HSA-9674555);  (R-HSA-9679191);  (R-HSA-9705462);  (R-HSA-9705671);  (R-HSA-9732724);  (R-HSA-9833109);  (R-HSA-9931295);  (R-HSA-9958825)",
        "pathway_count": 33,
        "publication_count": 792,
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        "class_list": "",
        "function": "CD146[+]CAFs promote progression of endometrial cancer by inducing angiogenesis and vasculogenic mimicry via IL-10/JAK1/STAT3 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; Individuals with JAK1 variants are affected by syndromic features encompassing autoimmunity, atopy, colitis, and dermatitis. Erratum:[J Exp Med. 2024 Jun 3;221(6):e2023238704302024c. doi: 10.1084/jem.2023238704302024c. PMID: 38709237], [RefSeq, PubMed]; Non-membrane spanning protein tyrosine kinase that phosphorylates signal-transducing subunits of cytokine receptor complexes like IL2RB, IL10RA, IFNAR2, IL6ST, LIFR, OSMR and IL31RA (PubMed:11909529, PubMed:12133952, PubMed:15194700, PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552, PubMed:9188471). Functionnally, is involved in the IFN-alpha/beta/gamma signal pathway (PubMed:16239216, PubMed:28111307, PubMed:32750333, PubMed:7615558, PubMed:8232552). Mechanistically, in response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins (PubMed:7759950). Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors (PubMed:16239216, PubMed:32750333, PubMed:8232552). Involved in the MT-RNR2/humanin-mediated signaling pathway leading to STAT3 phosphorylation (PubMed:27384491). Binding of CNTF or the CLCF1/CLF heterodimer to CNTFR leads to IL6ST/gp130-LIFR dimerization followed by activation of JAK1 and JAK2 which in turns phosphorylate IL6ST/gp130 and LIFR (PubMed:11294841). The tyrosine phosphorylated signaling receptors serve in turn as docking proteins for STAT3 (PubMed:11294841). Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (PubMed:9188471). Involved in the oncostatin-M-mediated signaling pathway through both type I OSM receptor complex (heterodimers composed of LIFR and IL6ST) and type II OSM receptor complex (heterodimers composed of OSMR and IL6ST) (PubMed:9188471). Involved in the Interleukin-31-mediated signaling pathway through the IL31 receptor complex (heterodimers composed of OSMR and IL31RA) (PubMed:15194700)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; Single-cell deconvolution algorithms analysis unveils autocrine IL11-mediated resistance to docetaxel in prostate cancer via activation of the JAK1/STAT4 pathway. Erratum:[J Exp Clin Cancer Res. 2024 Dec 28;43(1):333. doi: 10.1186/s13046-024-03257-8. PMID: 39731134] Publication Status: Online-Only, [RefSeq, PubMed]; The Janus kinase 1 is critical for pancreatic cancer initiation and progression., [RefSeq, PubMed]; This gene encodes a membrane protein that is a member of a class of protein-tyrosine kinases (PTK) characterized by the presence of a second phosphotransferase-related domain immediately N-terminal to the PTK domain. The encoded kinase phosphorylates STAT proteins (signal transducers and activators of transcription) and plays a key role in interferon-alpha/beta, interferon-gamma, and cytokine signal transduction. This gene plays a crucial role in effecting the expression of genes that mediate inflammation, epithelial remodeling, and metastatic cancer progression. This gene is a key component of the interleukin-6 (IL-6)/JAK1/STAT3 immune and inflammation response and is a therapeutic target for alleviating cytokine storms. The kinase activity of this gene is directly inhibited by the suppressor of cytokine signalling 1 (SOCS1) protein. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2020]., [RefSeq]; Tyrosine kinase of the non-receptor type, involved in the IFN-alpha/beta/gamma signal pathway. Kinase partner for the interleukin (IL)-2 receptor as well as interleukin (IL)-10 receptor. Kinase partner for the type I interferon receptor IFNAR2. In response to interferon-binding to IFNAR1-IFNAR2 heterodimer, phosphorylates and activates its binding partner IFNAR2, creating docking sites for STAT proteins. Directly phosphorylates STAT proteins but also activates STAT signaling through the transactivation of other JAK kinases associated with signaling receptors., [UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]",
        "predicted_glycosites": 2,
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        "reported_n_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 1,
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        "total_reported_n_glycosites": 1,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 16,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 73,
        "reported_interactions": 0,
        "missing_score": 8796,
        "biomarker_type": "",
        "glycan_count": 2,
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        "glyco_site_count": 3,
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        "secondary_ac_list": "Q59GQ2;Q9UD26",
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        "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0004715 non-membrane spanning protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0046872 metal ion binding;GO:0031625 ubiquitin protein ligase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005768 endosome;GO:0005788 endoplasmic reticulum lumen;GO:0005829 cytosol",
        "go_biological_process": "GO:0035771 interleukin-4-mediated signaling pathway;GO:0038110 interleukin-2-mediated signaling pathway;GO:1903672 positive regulation of sprouting angiogenesis;GO:0150105 protein localization to cell-cell junction;GO:0038043 interleukin-5-mediated signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 79.6,
        "record_id": "P23458-1",
        "record_type": "protein",
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    },
    {
        "uniprot_canonical_ac": "Q96MG7-1",
        "uniprot_id": [
            {
                "id": "NSE3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q96MG7",
                "type": "external"
            }
        ],
        "mass": 34308.0,
        "length": 304,
        "protein_name": "Non-structural maintenance of chromosomes element 3 homolog",
        "gene_name": "NSMCE3",
        "organism": "Human",
        "refseq_name": "non-structural maintenance of chromosomes element 3 homolog",
        "refseq_ac": [
            {
                "id": "NP_619649",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_619649",
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            }
        ],
        "gene_names_uniprotkb": "NSMCE3; HCA4; MAGEG1; NDNL2",
        "gene_names_refseq": "HCA4; LICS; MAGEG1; MAGEL3; NDNL2; NSE3; NSMCE3",
        "protein_names_uniprotkb": "Non-structural maintenance of chromosomes element 3 homolog; Hepatocellular carcinoma-associated protein 4; MAGE-G1 antigen; Melanoma-associated antigen G1; Necdin-like protein 2; Non-SMC element 3 homolog",
        "protein_names_refseq": "MAGE-G1 antigen; NSE3 homolog, SMC5-SMC6 complex component; hepatocellular carcinoma-associated protein 4; hepatocellular carcinoma-associated protein HCA4; melanoma antigen, family G, 1; melanoma-associated antigen G1; necdin-like 2, SMC5-SMC6 complex component; necdin-like gene 2; necdin-like protein 2; non-SMC element 3 homolog; non-structural maintenance of chromosomes element 3 homolog",
        "tax_id": 9606,
        "disease": "lung disease, immunodeficiency, and chromosome breakage syndrome; (MONDO:MONDO:0014984)",
        "pathway": " (hsa:56160);  (R-HSA-3108214)",
        "pathway_count": 2,
        "publication_count": 116,
        "publication_id_list": "10574707;11782285;11792325;11889051;15175327;15302935;15355988;15608651;15823533;15829507;15940266;15959518;16030353;16478998;16608850;16626738;16688858;16810316;17525332;17693435;18077418;18086888;18160138;18625722;18669648;18691969;18708356;18991276;19287951;19413330;19596686;19622798;19664995;19706679;19779455;19956565;20016594;20016603;20068230;20068231;20112406;20190268;20705237;20864041;21098080;21147198;21284855;21364888;21550342;22508508;22635276;22661230;22751501;23186163;23481700;23750026;23871147;24027577;24275569;24782567;25114211;25218447;25418920;25469497;25576301;26154972;26375851;26811146;26929215;26992070;27427983;27846572;27893789;27920218;28063628;28832583;28860189;28904123;29242379;29393594;29493099;29557506;29632046;29632711;30315122;30410026;30429286;30833945;31154438;31844290;31848261;32157095;32265295;32357974;32387766;32488085;32502341;32938616;33141586;33298915;33392160;33717175;33912179;33936100;33968037;34087483;34171305;34185709;34509645;34932366;35051231;35580925;9412458;9452416;9756909;9885291",
        "class_list": "",
        "function": "Component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination (PubMed:20864041, PubMed:27427983). The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination in ALT (alternative lengthening of telomeres) cell lines and mediates sumoylation of shelterin complex (telosome) components which is proposed to lead to shelterin complex disassembly in ALT-associated PML bodies (APBs). In vitro enhances ubiquitin ligase activity of NSMCE1. Proposed to act through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex (PubMed:20864041). May be a growth suppressor that facilitates the entry of the cell into cell cycle arrest (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed]; Gene expression, imprinting, and chromosome mapping of NDNL2, [RefSeq, PubMed]; NSMCE3 (also known as NDNL2) gene encodes a subunit of the SMC5/6 complex that is essential for DNA damage response and chromosome segregation, [RefSeq, PubMed]; The protein encoded by this gene is part of the SMC5-6 chromatin reorganizing complex and is a member of the MAGE superfamily. This is an intronless gene. [provided by RefSeq, May 2011]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_phosphosites": 5,
        "reported_mutagensis": 6,
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        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q8IW16;Q8TEI6;Q9H214",
        "ec_number_list": [],
        "go_molecular_function": "GO:0046983 protein dimerization activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000781 chromosome, telomeric region;GO:0030915 Smc5-Smc6 complex",
        "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0000122 negative regulation of transcription by RNA polymerase II;GO:0006281 DNA repair;GO:0016925 protein sumoylation;GO:0031398 positive regulation of protein ubiquitination",
        "synthesized_glycan_count": 0,
        "hit_score": 11.7,
        "record_id": "Q96MG7-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8WV24-1",
        "uniprot_id": [
            {
                "id": "PHLA1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8WV24",
                "type": "external"
            }
        ],
        "mass": 45016.0,
        "length": 401,
        "protein_name": "Pleckstrin homology-like domain family A member 1",
        "gene_name": "PHLDA1",
        "organism": "Human",
        "refseq_name": "pleckstrin homology-like domain family A member 1",
        "refseq_ac": [
            {
                "id": "NP_031376",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_031376",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PHLDA1; PHRIP; TDAG51",
        "gene_names_refseq": "DT1P1B11; PHLDA1; PHRIP; TDAG51",
        "protein_names_uniprotkb": "Pleckstrin homology-like domain family A member 1; Apoptosis-associated nuclear protein; PQ-rich protein; PQR protein; Proline- and glutamine-rich protein; Proline- and histidine-rich protein; T-cell death-associated gene 51 protein",
        "protein_names_refseq": "PQ-rich protein; PQR protein; T-cell death-associated gene 51 protein; apoptosis-associated nuclear protein; pleckstrin homology-like domain family A member 1; proline- and glutamine-rich protein; proline- and histidine-rich protein; proline-histidine rich protein",
        "tax_id": 9606,
        "disease": "retinal degeneration (Disease Ontology:DOID:8466)",
        "pathway": " (hsa:22822);  (R-HSA-8854521);  (R-HSA-9841922)",
        "pathway_count": 3,
        "publication_count": 45,
        "publication_id_list": "10425206;10558993;10835357;10882139;10894922;11027271;11237011;11369516;12384558;12738777;12829629;1310260;16380219;17761950;19043829;19172745;21807936;29242379;31154438;31222486;31844290;31848261;32488085;32983136;33141586;33179538;33329381;33537174;33968037;33982211;34185709;35051231;35580925;36010968;36107262;36241641;37155089;37938771;38237682;38665916;8521497;8521498;9065481;9171241;9744270",
        "class_list": "",
        "function": "BMP4 and PHLDA1 are plausible drug-targetable candidate genes for KRAS G12A-, G12D-, and G12V-driven colorectal cancer., [RefSeq, PubMed]; PHLDA1 is a P53 target gene involved in P53-mediated cell apoptosis., [RefSeq, PubMed]; PHLDA1 promotes glioblastoma cell growth via sustaining the activation state of Ras. Publication Status: Online-Only, [RefSeq, PubMed]; Prognostic and predictive value of Pleckstrin homology-like domain, family A family members in breast cancer., [RefSeq, PubMed]; Restoration of the ER stress response protein TDAG51 in hepatocytes mitigates NAFLD in mice., [RefSeq, PubMed]; Seems to be involved in regulation of apoptosis. May be involved in detachment-mediated programmed cell death. May mediate apoptosis during neuronal development. May be involved in regulation of anti-apoptotic effects of IGF1. May be involved in translational regulation., [UniProtKB, PubMed, PubMed]; The progressive loss of PHLDA1 expression in melanomas may play a role in deregulated cell growth and apoptosis resistance in these tumors., [RefSeq, PubMed]; This gene encodes an evolutionarily conserved proline-histidine rich nuclear protein. The encoded protein may play an important role in the anti-apoptotic effects of insulin-like growth factor-1. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
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        "reported_snv": 2,
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        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1A4G9;Q15184;Q2TAN2;Q9NZ17",
        "ec_number_list": [],
        "go_molecular_function": "GO:1901981 phosphatidylinositol phosphate binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005730 nucleolus;GO:0005829 cytosol;GO:0031410 cytoplasmic vesicle;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0043065 positive regulation of apoptotic process;GO:0006915 apoptotic process",
        "synthesized_glycan_count": 0,
        "hit_score": 4.8,
        "record_id": "Q8WV24-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8TE67-1",
        "uniprot_id": [
            {
                "id": "ES8L3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8TE67",
                "type": "external"
            }
        ],
        "mass": 66861.0,
        "length": 593,
        "protein_name": "Epidermal growth factor receptor kinase substrate 8-like protein 3",
        "gene_name": "EPS8L3",
        "organism": "Human",
        "refseq_name": "epidermal growth factor receptor kinase substrate 8-like protein 3 isoform d",
        "refseq_ac": [
            {
                "id": "NP_001306881",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001306881",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPS8L3; EPS8R3",
        "gene_names_refseq": "EPS8L3; EPS8R3; HYPT5; MUHH2",
        "protein_names_uniprotkb": "Epidermal growth factor receptor kinase substrate 8-like protein 3; EPS8-like protein 3; EPS8-related protein 3; Epidermal growth factor receptor pathway substrate 8-related protein 3",
        "protein_names_refseq": "EPS8 like 3; EPS8-like protein 3; EPS8-related protein 3; epidermal growth factor receptor kinase substrate 8-like protein 3 isoform d; epidermal growth factor receptor kinase substrate 8-like protein 3; epidermal growth factor receptor pathway substrate 8-related protein 3",
        "tax_id": 9606,
        "disease": "hypotrichosis 5 (Disease Ontology:DOID:0110702)",
        "pathway": " (hsa:79574)",
        "pathway_count": 1,
        "publication_count": 17,
        "publication_id_list": "11237011;12620401;14565974;18452278;19223546;19807924;23099647;23186163;28411811;29940761;31322213;32938616;34171305;35051231;36010968;36284347;38750898",
        "class_list": "",
        "function": "EPS8L3 might promote proliferation by hyperactivating the AKT signaling pathway and subsequently inhibiting the FOXO1 transcriptional activity in hepatocellular carcinoma, [RefSeq, PubMed]; Sorted-Cell Sequencing on HCC Specimens Reveals EPS8L3 as a Key Player in CD24/CD13/EpCAM-Triple Positive, Stemness-Related HCC Cells., [RefSeq, PubMed]; The results revealed that EPS8L3 expression was significantly upregulated in liver cancer tissues and cell lines (P<0.01), and that the expression of EPS8L3 was closely associated with grade (P=0.024) and mortality (P=0.011)., [RefSeq, PubMed]; The results suggest that EPS8L3 is a causative gene for Marie Unna hereditary hypotrichosis., [RefSeq, PubMed]; This gene encodes a protein that is related to epidermal growth factor receptor pathway substrate 8 (EPS8), a substrate for the epidermal growth factor receptor. The function of this protein is unknown. Alternatively spliced transcript variants encoding different isoforms exist. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 1,
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        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K833;Q5T8Q6;Q5T8Q7;Q5T8Q8;Q96E47;Q9H719",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003779 actin binding;GO:0005085 guanyl-nucleotide exchange factor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005886 plasma membrane;GO:0032587 ruffle membrane",
        "go_biological_process": "GO:0007266 Rho protein signal transduction;GO:0035023 regulation of Rho protein signal transduction;GO:0042634 regulation of hair cycle;GO:1900029 positive regulation of ruffle assembly",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q8TE67-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5XX13-1",
        "uniprot_id": [
            {
                "id": "FBW10_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5XX13",
                "type": "external"
            }
        ],
        "mass": 119846.0,
        "length": 1052,
        "protein_name": "F-box/WD repeat-containing protein 10",
        "gene_name": "FBXW10",
        "organism": "Human",
        "refseq_name": "F-box/WD repeat-containing protein 10 isoform 1",
        "refseq_ac": [
            {
                "id": "NP_001254514",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001254514",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FBXW10",
        "gene_names_refseq": "FBXW10; Fbw10; HREP; SM25H2; SM2SH2",
        "protein_names_uniprotkb": "F-box/WD repeat-containing protein 10; F-box and WD-40 domain-containing protein 10; Ubiquitin ligase-specificity factor",
        "protein_names_refseq": "F-box and WD-40 domain protein 10; F-box/WD repeat-containing protein 10 isoform 1; F-box/WD repeat-containing protein 10; testicular tissue protein Li 69; ubiquitin ligase specificity factor",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10517);  (R-HSA-390471);  (R-HSA-8951664);  (R-HSA-983168)",
        "pathway_count": 4,
        "publication_count": 149,
        "publication_id_list": "10535940;10597293;10811609;10878807;10973499;11062501;11069780;11230166;11237011;11259415;11292861;11292862;11350924;11454738;11585840;11733065;11961546;12101228;12186903;12502735;12504025;12504026;12526791;12538644;12609982;12646216;12682069;12759363;12816948;14690597;14734113;14757770;15224091;15224092;15282312;15361859;15367669;15520277;15537541;15571818;15572695;15574592;15601839;15652483;15688063;15694336;15799966;16171779;16401342;16547496;16595681;16647857;16707496;16790436;16849449;16943200;16954532;17081101;17132228;17183367;17220875;17332328;17497243;17785452;18093314;18206966;18662542;18775313;18775504;18776931;18805092;18826954;18851830;18926707;19011634;19028597;19250909;19321346;19352404;19452197;19489725;19617556;19748355;19851334;19874575;19940261;20498703;21098288;21447816;21463634;21778237;21863050;21940857;21995946;22306028;22466964;22537386;2261476;22959436;23201271;23333871;23401859;23453757;23535662;23535663;23563313;23583660;23747015;23899520;23912815;23986495;24076655;24366543;24636985;24756126;24793695;24793696;25314029;25342745;25349211;25355947;25467444;25531226;26344709;26460955;26632597;26768311;26906416;27030794;27222660;27565346;28115426;29153394;29557506;30379171;30610225;31400758;32005965;32284348;33444648;35051231;36990424;37775405;9380723;9668046;9790970;9819444;9887101;9891082",
        "class_list": "",
        "function": "FBXW10 promotes hepatocarcinogenesis in male patients and mice., [RefSeq, PubMed]; FBXW10: a male-biased E3 ligase in liver cancer., [RefSeq, PubMed]; Members of the F-box protein family, such as FBXW10, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Mar 2008]., [RefSeq]; Mislocalized lamins can induce ubiquitin-mediated proteasomal degradation of certain HP1 isoforms by activation of FBXW10, a member of the F-box family of proteins that is involved in E3 ubiquitin ligase activity. Publication Status: Online-Only, [RefSeq, PubMed]; O-GlcNAcylation is involved in the regulation of ubiquitination-related genes including FBXW10, [RefSeq, PubMed]; Probable substrate-recognition component of a SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Overexpression is leading to degradation of CBX5 and CBX1., [UniProtKB, PubMed]; The E3 ubiquitin ligase SCF (FBXW10)-mediated LATS2 degradation regulates angiogenesis and liver metastasis in colorectal cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
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        "reported_snv": 28,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
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        "glyco_site_count": 1,
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        "secondary_ac_list": "C9JRY8;C9JZD7;Q8TC00;Q9H0F0",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005829 cytosol",
        "go_biological_process": "GO:0031146 SCF-dependent proteasomal ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 15.2,
        "record_id": "Q5XX13-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q03591-1",
        "uniprot_id": [
            {
                "id": "FHR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q03591",
                "type": "external"
            }
        ],
        "mass": 37651.0,
        "length": 330,
        "protein_name": "Complement factor H-related protein 1",
        "gene_name": "CFHR1",
        "organism": "Human",
        "refseq_name": "complement factor H-related protein 1 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_002104",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002104",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "CFHR1; CFHL1P; CFHL1; CFHL; CFHR1P; FHR1; HFL1; HFL2",
        "gene_names_refseq": "CFHL1P; CFHL1; CFHL; CFHR1P; CFHR1; FHL-1; FHR-1; FHR1; H36-1; H36-2; H36; HFL1; HFL2",
        "protein_names_uniprotkb": "Complement factor H-related protein 1; FHL-1; FHR-1; H factor-like protein 1; H-factor-like 1; H36",
        "protein_names_refseq": "H factor (complement)-like 1; H factor (complement)-like 2; H-factor-like 1; complement factor H-related 1 pseudogene; complement factor H-related protein 1 isoform 1 precursor; complement factor H-related protein 1; h factor-like protein 1",
        "tax_id": 9606,
        "disease": "atypical hemolytic-uremic syndrome (Disease Ontology:DOID:0080301); age related macular degeneration 1 (Disease Ontology:DOID:0110014); acute myeloid leukemia (Disease Ontology:DOID:9119); multiple myeloma (Disease Ontology:DOID:9538); hemolytic uremic syndrome, atypical, susceptibility to, 1 (MONDO:MONDO:0009335)",
        "pathway": " (hsa:3078);  (R-HSA-977606)",
        "pathway_count": 2,
        "publication_count": 69,
        "publication_id_list": "10531307;1067618;10781834;11237011;11694537;11939578;12055245;1386357;16079145;16192651;16335952;16999828;1711047;17182573;17367211;17505110;18006700;1825108;1826708;21788512;22802338;23090970;23204165;23487775;2420889;2465906;2466593;2481448;29242379;293688;293746;29391424;29557506;2956252;2971659;29741879;301546;33968037;35051231;36755127;36793547;37032353;37074911;38286352;3848661;4098172;6214588;6219696;6222381;6230668;6238120;6334079;6454142;6607952;670886;6906228;702059;7391570;7542572;760802;761607;7690834;7691959;8172644;8345200;8495193;8786315;9038722;978134",
        "class_list": "",
        "function": "CFH and CFHR structural variants in atypical Hemolytic Uremic Syndrome: Prevalence, genomic characterization and impact on outcome. Publication Status: Online-Only, [RefSeq, PubMed]; CFH-CFHR1 hybrid genes in two cases of atypical hemolytic uremic syndrome., [RefSeq, PubMed]; CFHR1 involvement in bile duct carcinoma: Insights from a data mining study., [RefSeq, PubMed]; Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism., [UniProtKB, PubMed, UniProtKB, UniProtKB]; The absence of CFHR3 and CFHR1 genes from the T2T-CHM13 assembly can limit the molecular diagnosis of complement-related diseases., [RefSeq, PubMed]; This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement, and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical hemolytic-uremic syndrome. [provided by RefSeq, Oct 2009]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 13,
        "reported_interactions": 0,
        "missing_score": 8657,
        "biomarker_type": "",
        "glycan_count": 36,
        "disease_count": 5,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K465;Q3B774;Q9UJ17",
        "ec_number_list": [],
        "go_molecular_function": "GO:0042802 identical protein binding;GO:0001851 complement component C3b binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0072562 blood microparticle;GO:0032991 protein-containing complex",
        "go_biological_process": "GO:0032091 negative regulation of protein binding;GO:0051838 cytolysis by host of symbiont cells;GO:0006956 complement activation",
        "synthesized_glycan_count": 0,
        "hit_score": 10.8,
        "record_id": "Q03591-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O00602-1",
        "uniprot_id": [
            {
                "id": "FCN1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O00602",
                "type": "external"
            }
        ],
        "mass": 35078.0,
        "length": 326,
        "protein_name": "Ficolin-1",
        "gene_name": "FCN1",
        "organism": "Human",
        "refseq_name": "ficolin-1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001994",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001994",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FCN1; FCNM",
        "gene_names_refseq": "FCN1; FCNM",
        "protein_names_uniprotkb": "Ficolin-1; Collagen/fibrinogen domain-containing protein 1; Ficolin-A; Ficolin-alpha; M-ficolin",
        "protein_names_refseq": "M-ficolin; ficolin (collagen/fibrinogen domain-containing) 1; ficolin-1 precursor; ficolin-A; ficolin-alpha",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2219);  (R-HSA-166662);  (R-HSA-166663);  (R-HSA-2855086);  (R-HSA-6798695)",
        "pathway_count": 5,
        "publication_count": 64,
        "publication_id_list": "10639434;10679061;10925294;11012776;11532276;11907111;12367778;12396008;14280442;14702039;14707097;15078867;15164053;15199963;15340161;15489334;15728497;15804047;16116205;16959974;17148457;17215869;17897951;17938215;18343499;18596036;20032467;20375619;20375634;20400674;21037097;21730084;22238349;23650620;26154972;26173080;27726376;29557506;29632711;30619357;31154438;32142211;32601370;32915797;32983136;33091337;33591573;33600013;34212320;34686494;35051231;35580925;36284347;37996869;6019133;70787;7391573;7686157;8538770;8573080;8576206;8692836;8884275;8947836",
        "class_list": "glycogene",
        "function": "Extracellular lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:16116205, PubMed:17897951, PubMed:20032467). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:16116205, PubMed:20032467). Binds preferentially to 9-O-acetylated 2-6-linked sialic acid derivatives and to various glycans containing sialic acid engaged in a 2-3 linkage (PubMed:20032467, PubMed:20400674). May also activate monocytes through a G protein-coupled receptor, FFAR2, inducing the secretion of interleukin-8/IL-8 (PubMed:21037097)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; FCN1 polymorphisms are not the markers of dental caries susceptibility in Polish children: A case-control study., [RefSeq, PubMed]; Increased Levels of serum Pentraxin 3 in Critical Coronavirus Disease-2019 Patients., [RefSeq, PubMed]; Increased expression of ficolin-1 is associated with airway obstruction in asthma. Publication Status: Online-Only, [RefSeq, PubMed]; M-ficolin: a valuable biomarker to identify leukaemia from juvenile idiopathic arthritis., [RefSeq, PubMed]; The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins.  However, all these proteins recognize different targets, and are functionally distinct.  Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 517,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5VYV5;Q92596",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0001664 G protein-coupled receptor binding;GO:0030246 carbohydrate binding;GO:0033691 sialic acid binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0031012 extracellular matrix;GO:0034774 secretory granule lumen",
        "go_biological_process": "GO:0006508 proteolysis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0032757 positive regulation of interleukin-8 production;GO:0034394 protein localization to cell surface;GO:0001867 complement activation, lectin pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 6.5,
        "record_id": "O00602-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000010000.001.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14512-1",
        "uniprot_id": [
            {
                "id": "FGFP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14512",
                "type": "external"
            }
        ],
        "mass": 26264.0,
        "length": 234,
        "protein_name": "Fibroblast growth factor-binding protein 1",
        "gene_name": "FGFBP1",
        "organism": "Human",
        "refseq_name": "fibroblast growth factor-binding protein 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_005121",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_005121",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FGFBP1; FGFBP; HBP17",
        "gene_names_refseq": "FGF-BP1; FGF-BP; FGFBP-1; FGFBP1; FGFBP; HBP17",
        "protein_names_uniprotkb": "Fibroblast growth factor-binding protein 1; 17 kDa HBGF-binding protein; 17 kDa heparin-binding growth factor-binding protein; FGF-BP1; FGF-BP; FGF-binding protein 1; FGFBP-1; HBp17",
        "protein_names_refseq": "17 kDa HBGF-binding protein; 17 kDa heparin-binding growth factor-binding protein; FGF-binding protein 1; fibroblast growth factor-binding protein 1 precursor; heparin-binding growth factor binding protein",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:9982);  (R-HSA-190377)",
        "pathway_count": 2,
        "publication_count": 24,
        "publication_id_list": "10.1038/emboj.2013.79;10.1074/mcp.M114.046862;11148217;11294897;11509569;1379698;15806171;15863029;16257968;16324873;1656221;16597617;1697263;1885605;23584533;25813380;31154438;33381388;33592498;34117747;34341336;37076641;8622701;9334727",
        "class_list": "",
        "function": "Acts as a carrier protein that release fibroblast-binding factors (FGFs) from the extracellular matrix (EM) storage and thus enhance the mitogenic activity of FGFs. Enhances FGF2 signaling during tissue repair, angiogenesis and in tumor growth., [UniProtKB, PubMed, PubMed, PubMed, PubMed]; FGFBP1-mediated crosstalk between fibroblasts and pancreatic cancer cells via FGF22/FGFR2 promotes invasion and metastasis of pancreatic cancer., [RefSeq, PubMed]; HAI-1 is required for the novel role of FGFBP1 in maintenance of cell morphology and F-actin rearrangement in human keratinocytes., [RefSeq, PubMed]; Poly-L-arginine promotes asthma angiogenesis through induction of FGFBP1 in airway epithelial cells via activation of the mTORC1-STAT3 pathway. Publication Status: Online-Only, [RefSeq, PubMed]; The Expression and Prognostic Value of FGF2, FGFR3, and FGFBP1 in Esophageal Squamous Cell Carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a secreted fibroblast growth factor carrier protein. The encoded protein plays a critical role in cell proliferation, differentiation and migration by binding to fibroblast growth factors and potentiating their biological effects on target cells. The encoded protein may also play a role in tumor growth as an angiogenic switch molecule, and expression of this gene has been associated with several types of cancer including pancreatic and colorectal adenocarcinoma. A pseudogene of this gene is also located on the short arm of chromosome 4. [provided by RefSeq, Nov 2011]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "reported_o_glycosites_with_glycan": 14,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 14,
        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_snv": 21,
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        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K5J2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0008201 heparin binding;GO:0019838 growth factor binding;GO:0017134 fibroblast growth factor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface",
        "go_biological_process": "GO:0007165 signal transduction;GO:0007267 cell-cell signaling;GO:0008285 negative regulation of cell population proliferation;GO:0090050 positive regulation of cell migration involved in sprouting angiogenesis;GO:1903589 positive regulation of blood vessel endothelial cell proliferation involved in sprouting angiogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 4.0,
        "record_id": "Q14512-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0100000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P17181-1",
        "uniprot_id": [
            {
                "id": "INAR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P17181",
                "type": "external"
            }
        ],
        "mass": 63525.0,
        "length": 557,
        "protein_name": "Interferon alpha/beta receptor 1",
        "gene_name": "IFNAR1",
        "organism": "Human",
        "refseq_name": "interferon alpha/beta receptor 1 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_000620",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000620",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "IFNAR1; IFNAR",
        "gene_names_refseq": "AVP; CRF2-1; IFN-R-1; IFN-alpha-REC; IFNAR1; IFNAR; IFNBR; IFRC; IMD106",
        "protein_names_uniprotkb": "Interferon alpha/beta receptor 1; CRF2-1; Cytokine receptor class-II member 1; Cytokine receptor family 2 member 1; IFN-R-1; IFN-alpha/beta receptor 1; Type I interferon receptor 1",
        "protein_names_refseq": "IFN-alpha/beta receptor 1; IFNalpha/beta receptor 1; alpha-type antiviral protein; beta-type antiviral protein; cytokine receptor class-II member 1; cytokine receptor family 2 member 1; interferon (alpha, beta and omega) receptor 1; interferon alpha/beta receptor 1 isoform 2 precursor; interferon alpha/beta receptor 1; interferon-alpha/beta receptor alpha chain; interferon-beta receptor 1; type I interferon receptor 1",
        "tax_id": 9606,
        "disease": "immunodeficiency 106 (Disease Ontology:DOID:0061075); hepatitis C (Disease Ontology:DOID:1883)",
        "pathway": " (hsa:3454);  (R-HSA-909733);  (R-HSA-912694);  (R-HSA-9679191);  (R-HSA-9705671);  (R-HSA-9833109)",
        "pathway_count": 6,
        "publication_count": 248,
        "publication_id_list": "10.1101/2023.09.13.557529;10022928;10049744;10087012;10395669;10542297;10982844;11092454;11237011;11337497;11377645;11404376;11585831;11694501;11786546;12019269;12029096;12220192;12692549;12759408;12766484;12842042;1370833;14532120;14769151;15047845;15208624;15312780;15337770;15449939;15659558;15778442;16009940;16115318;16125763;16127453;16171819;16522641;16551269;16710296;16987978;17251292;1730654;17351669;17392790;17662961;17969444;18035202;18056411;18508557;18575461;18578522;19193793;19349973;19413330;19561067;19690332;19805514;20130243;20223979;20363976;20643137;2153461;21632562;21666722;21695243;21854986;21865166;2211721;22383950;22401777;22552008;22814904;22941947;23061660;23090970;23121362;23186163;23481700;23641311;24075985;24190977;24272870;24417533;24584101;24704786;25371710;25576301;25801024;26002965;26154972;27846572;27893789;28218747;28228285;28425720;28467828;28514659;28649982;28904123;29242379;29314611;29317506;29391424;29393594;29437277;29557506;29632046;29632711;29786170;29945920;30201761;30315122;30410026;30485383;30524438;30558248;31048504;31092671;31270247;31844290;31850239;32032529;32113509;32157095;32161166;32265295;32350084;32353859;32357974;32428392;32488085;32502341;32511913;32574262;32589897;32661006;32726803;32728199;32758689;32862111;32897882;32938616;32953130;32972995;32979938;33024073;33060197;33097660;33110251;33117408;33141586;33189161;33193462;33252644;33298915;33349665;33360543;33372174;33372854;33392160;33396578;33396605;33440148;33479219;33495715;33514628;33567255;33691108;33718825;33723219;33723527;33727702;33801464;33807682;33811647;33849972;33895773;33912179;33936100;33963333;33968037;33981976;33989516;33990585;34021074;34054808;34084167;34087483;34110168;34166398;34171305;34239064;34290717;34341353;34357683;34375313;34400613;34439781;34452305;34471099;34502139;34597346;35051231;35102342;35154160;35251023;35442418;35561310;35580925;35643212;35816776;35985475;36010968;36063748;36215666;36241641;37028439;37051252;37074911;37938771;37973454;39894887;6162102;6548414;688397;7510216;7526154;7537377;7540766;7665574;7813427;8197134;8232552;8307198;8315383;8605876;8621447;8702790;8943354;9096384;9121453;9242679;9334213;9660177;9677371;9847332;9861020",
        "class_list": "",
        "function": "Association of IFNAR1 and IFNAR2 with COVID-19 severity. Erratum:[Lancet Microbe. 2023 Jun;4(6):e394. doi: 10.1016/S2666-5247(23)00116-7. PMID: 37068499], [RefSeq, PubMed]; Beyond fusion: A novel role for ERVW-1 in trophoblast proliferation and type I interferon receptor expression., [RefSeq, PubMed]; CK1alpha upregulates the IFNAR1 expression to prompt the anti-HBV effect of type I IFN in hepatoma carcinoma cells., [RefSeq, PubMed]; Correlation between IFNAR1 expression in peripheral blood T lymphocytes and inflammatory cytokines, tumor-infiltrating lymphocytes, and chemosensitivity in patients with colorectal cancer., [RefSeq, PubMed]; Detection of interferon alpha and beta receptor subunit 1 (IFNAR1) loss-of-function Glu386 * variant by tri-allelic genotyping., [RefSeq, PubMed]; The protein encoded by this gene is a type I membrane protein that forms one of the two chains of a receptor for interferons alpha and beta. Binding and activation of the receptor stimulates Janus protein kinases, which in turn phosphorylate several proteins, including STAT1 and STAT2. The protein belongs to the type II cytokine receptor family and functions as an antiviral factor. [provided by RefSeq, Jul 2020]., [RefSeq]; Together with IFNAR2, forms the heterodimeric receptor for type I interferons (including interferons alpha, beta, epsilon, omega and kappa). Type I interferon binding activates the JAK-STAT signaling cascade. Can also act independently of IFNAR2: form an active IFNB1 receptor by itself and activate a signaling cascade that does not involve activation of the JAK-STAT pathway., [UniProtKB, UniProtKB, UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
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        "mined_s_glycosites": 0,
        "reported_n_glycosites": 9,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 8,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 10,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 10,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 11,
        "reported_mutagensis": 9,
        "reported_glycation": 0,
        "reported_snv": 33,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 14,
        "disease_count": 2,
        "glyco_site_count": 13,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R6L9;B4DNT3;D3DSF0;Q53GW9;Q53H11;Q6PKD7;Q7M4L2;Q8WTZ2",
        "ec_number_list": [],
        "go_molecular_function": "GO:0019955 cytokine binding;GO:0008269 JAK pathway signal transduction adaptor activity;GO:0004905 type I interferon receptor activity;GO:0019962 type I interferon binding",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0005764 lysosome;GO:0005770 late endosome",
        "go_biological_process": "GO:0035457 cellular response to interferon-alpha;GO:0032496 response to lipopolysaccharide;GO:0060337 type I interferon-mediated signaling pathway;GO:0009615 response to virus;GO:0035458 cellular response to interferon-beta",
        "synthesized_glycan_count": 0,
        "hit_score": 27.4,
        "record_id": "P17181-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UW88-1",
        "uniprot_id": [
            {
                "id": "EPGN_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UW88",
                "type": "external"
            }
        ],
        "mass": 17091.0,
        "length": 154,
        "protein_name": "Epigen",
        "gene_name": "EPGN",
        "organism": "Human",
        "refseq_name": "epigen isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001257918",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001257918",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPGN; PRO9904",
        "gene_names_refseq": "ALGV3072; EPGN; EPG; PRO9904",
        "protein_names_uniprotkb": "Epigen; EPG; Epithelial mitogen",
        "protein_names_refseq": "epigen isoform 1 precursor; epigen; epithelial mitogen homolog",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:255324);  (R-HSA-1257604);  (R-HSA-177929);  (R-HSA-179812);  (R-HSA-180292);  (R-HSA-180336);  (R-HSA-182971);  (R-HSA-212718);  (R-HSA-2219530);  (R-HSA-5638303);  (R-HSA-5673001);  (R-HSA-6811558);  (R-HSA-8856825);  (R-HSA-8856828);  (R-HSA-9009391);  (R-HSA-9634638)",
        "pathway_count": 16,
        "publication_count": 476,
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        "class_list": "",
        "function": "Cloning of a related gene in mouse, [RefSeq, PubMed]; EPG is an EGF-like growth factor and a low affinity ligand, [RefSeq, PubMed]; Promotes the growth of epithelial cells. May stimulate the phosphorylation of EGFR and mitogen-activated protein kinases., [UniProtKB, PubMed, UniProtKB, UniProtKB]; Study shows how the EGFR ligands epiregulin (EREG) and epigen (EPGN) stabilize different dimeric conformations of the EGFR extracellular region. Results reveal how responses to different EGFR ligands are defined by receptor dimerization strength and signaling dynamics. These findings have broad implications for understanding receptor tyrosine kinase (RTK) signaling specificity., [RefSeq, PubMed]; The protein encoded by this gene is a member of the epidermal growth factor family. Members of this family are ligands for the epidermal growth factor receptor and play a role in cell survival, proliferation and migration. This protein has been reported to have high mitogenic activity but low affinity for its receptor. Expression of this transcript and protein have been reported in cancer specimens of the breast, bladder, and prostate. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2012]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A1BMM3;A1BMM4;A1BMM5;A1BMM6;A1BMM7;A1BMM8;A8K090",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030669 clathrin-coated endocytic vesicle membrane;GO:0016020 membrane",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0008284 positive regulation of cell population proliferation;GO:0043410 positive regulation of MAPK cascade;GO:0007173 epidermal growth factor receptor signaling pathway;GO:0050679 positive regulation of epithelial cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 47.7,
        "record_id": "Q6UW88-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000011000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9H6B9-1",
        "uniprot_id": [
            {
                "id": "EPHX3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9H6B9",
                "type": "external"
            }
        ],
        "mass": 40909.0,
        "length": 360,
        "protein_name": "Epoxide hydrolase 3",
        "gene_name": "EPHX3",
        "organism": "Human",
        "refseq_name": "epoxide hydrolase 3",
        "refseq_ac": [
            {
                "id": "NP_001136358",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001136358",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPHX3; ABHD9",
        "gene_names_refseq": "ABHD9; EH3; EPHX3",
        "protein_names_uniprotkb": "Epoxide hydrolase 3; 3.3.2.10; Abhydrolase domain-containing protein 9; EH3",
        "protein_names_refseq": "abhydrolase domain containing 9; abhydrolase domain-containing protein 9; epoxide hydrolase 3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:79852)",
        "pathway_count": 1,
        "publication_count": 8,
        "publication_id_list": "11237011;17437806;20723587;22798687;24718283;25880248;29786170;34066758",
        "class_list": "",
        "function": "Catalyzes the hydrolysis of epoxide-containing fatty acids. Active in vitro against epoxyeicosatrienoic acids (EETs) including 8,9-EET, 9,10-EET, 11,12-EET and 14,15-EET and leukotoxin., [UniProtKB, PubMed]; Methylation of the ABHD9 is significantly associated with prostate cancer prognosis., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Relative Importance of Soluble and Microsomal Epoxide Hydrolases for the Hydrolysis of Epoxy-Fatty Acids in Human Tissues. Publication Status: Online-Only, [RefSeq, PubMed]; The identification of two human epoxide hydrolases: EH3 and EH4., [RefSeq, PubMed]; These results validate the association between promoter hypermethylation of ABHD9 and HOXD3 and prostate cancer recurrence, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
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        "biomarker_type": "",
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        "secondary_ac_list": "A3KMR3",
        "ec_number_list": [
            {
                "id": "3.3.2.9",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.9",
                "type": "external"
            },
            {
                "id": "3.3.2.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.3.2.10",
                "type": "external"
            },
            {
                "id": "3.1.3.76",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.76",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0016787 hydrolase activity;GO:0004301 epoxide hydrolase activity",
        "go_cellular_component": "GO:0016020 membrane;GO:0043231 intracellular membrane-bounded organelle",
        "go_biological_process": "GO:0006629 lipid metabolic process;GO:0097176 epoxide metabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q9H6B9-1",
        "record_type": "protein",
        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
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    },
    {
        "uniprot_canonical_ac": "P14625-1",
        "uniprot_id": [
            {
                "id": "ENPL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P14625",
                "type": "external"
            }
        ],
        "mass": 92469.0,
        "length": 803,
        "protein_name": "Endoplasmin",
        "gene_name": "HSP90B1",
        "organism": "Human",
        "refseq_name": "endoplasmin precursor",
        "refseq_ac": [
            {
                "id": "NP_003290",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_003290",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "HSP90B1; GRP94; HSPC4; TRA1",
        "gene_names_refseq": "ECGP; GP96; GRP94; HEL-S-125m; HEL35; HSP90B1; TRA1",
        "protein_names_uniprotkb": "Endoplasmin; 3.6.4.-; 94 kDa glucose-regulated protein; GRP-94; Heat shock protein 90 kDa beta member 1; Heat shock protein family C member 4; Tumor rejection antigen 1; gp96 homolog",
        "protein_names_refseq": "94 kDa glucose-regulated protein; endoplasmin precursor; endoplasmin; endothelial cell (HBMEC) glycoprotein; epididymis luminal protein 35; epididymis secretory sperm binding protein Li 125m; heat shock protein 90 kDa beta member 1; heat shock protein 90kDa beta (Grp94), member 1; heat shock protein 90kDa beta family member 1; heat shock protein family C member 4; stress-inducible tumor rejection antigen gp96; tumor rejection antigen (gp96) 1; tumor rejection antigen 1",
        "tax_id": 9606,
        "disease": "male infertility due to globozoospermia (Disease Ontology:DOID:0112312); lung adenocarcinoma (Disease Ontology:DOID:3910)",
        "pathway": " (hsa:7184);  (R-HSA-1679131);  (R-HSA-3000480);  (R-HSA-381183);  (R-HSA-381426);  (R-HSA-6785807);  (R-HSA-8957275)",
        "pathway_count": 7,
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        "function": "A paper describing a pathway in which this gene product functions, [RefSeq, PubMed]; ATP-dependent chaperone involved in the processing of proteins in the endoplasmic reticulum, regulating their transport (PubMed:23572575, PubMed:39509507). Together with MESD, acts as a modulator of the Wnt pathway by promoting the folding of LRP6, a coreceptor of the canonical Wnt pathway (PubMed:23572575, PubMed:39509507). When associated with CNPY3, required for proper folding of Toll-like receptors (PubMed:11584270). Promotes folding and trafficking of TLR4 to the cell surface (PubMed:11584270). May participate in the unfolding of cytosolic leaderless cargos (lacking the secretion signal sequence) such as the interleukin 1/IL-1 to facilitate their translocation into the ERGIC (endoplasmic reticulum-Golgi intermediate compartment) and secretion; the translocation process is mediated by the cargo receptor TMED10 (PubMed:32272059)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB, UniProtKB]; OmpA of E. coli K1 interacts with a gp96-like molecule on HBMECs for invasion (Ecgp: 96-kDa human brain microvascular endothelial cell (HBMEC) glycoprotein), [RefSeq, PubMed]; This gene encodes a member of a family of adenosine triphosphate(ATP)-metabolizing molecular chaperones with roles in stabilizing and folding other proteins. The encoded protein is localized to melanosomes and the endoplasmic reticulum. Expression of this protein is associated with a variety of pathogenic states, including tumor formation. There is a microRNA gene located within the 5' exon of this gene. There are pseudogenes for this gene on chromosomes 1 and 15. [provided by RefSeq, Aug 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 8,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 6,
        "reported_o_glycosites_with_glycan": 8,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 8,
        "total_reported_o_glycosites": 8,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 8,
        "total_o_glycosites": 8,
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        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 4,
        "reported_phosphosites": 17,
        "reported_mutagensis": 8,
        "reported_glycation": 0,
        "reported_snv": 22,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 67,
        "disease_count": 2,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q96A97",
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        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0005524 ATP binding;GO:0050750 low-density lipoprotein particle receptor binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity",
        "go_cellular_component": "GO:0034663 endoplasmic reticulum chaperone complex;GO:0005576 extracellular region;GO:0005634 nucleus;GO:0005783 endoplasmic reticulum;GO:0005788 endoplasmic reticulum lumen",
        "go_biological_process": "GO:0034123 positive regulation of toll-like receptor signaling pathway;GO:0015031 protein transport;GO:0043066 negative regulation of apoptotic process;GO:0072659 protein localization to plasma membrane;GO:0001666 response to hypoxia",
        "synthesized_glycan_count": 0,
        "hit_score": 48.3,
        "record_id": "P14625-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P11161-1",
        "uniprot_id": [
            {
                "id": "EGR2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P11161",
                "type": "external"
            }
        ],
        "mass": 50302.0,
        "length": 476,
        "protein_name": "E3 SUMO-protein ligase EGR2",
        "gene_name": "EGR2",
        "organism": "Human",
        "refseq_name": "E3 SUMO-protein ligase EGR2 isoform a",
        "refseq_ac": [
            {
                "id": "NP_000390",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000390",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EGR2; KROX20",
        "gene_names_refseq": "AT591; CMT1D; CMT4E; EGR2; KROX20",
        "protein_names_uniprotkb": "E3 SUMO-protein ligase EGR2; 2.3.2.-; AT591; E3 SUMO-protein transferase ERG2; EGR-2; Early growth response protein 2; Zinc finger protein Krox-20",
        "protein_names_refseq": "E3 SUMO-protein ligase EGR2 isoform a; E3 SUMO-protein ligase EGR2; E3 SUMO-protein transferase ERG2; KROX-20, Drosophila, homolog (early growth response-2); early growth response protein 2; zinc finger protein Krox-20",
        "tax_id": 9606,
        "disease": "Charcot-Marie-Tooth disease type 3 (Disease Ontology:DOID:0050540); alcohol dependence (Disease Ontology:DOID:0050741); congenital hypomyelinating neuropathy (Disease Ontology:DOID:0070678); Charcot-Marie-Tooth disease type 1D (Disease Ontology:DOID:0110150); congenital hypomyelinating neuropathy 1 (Disease Ontology:DOID:0110195); hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); impulse control disorder (Disease Ontology:DOID:10937); personality disorder (Disease Ontology:DOID:1510); alcohol use disorder (Disease Ontology:DOID:1574); depressive disorder (Disease Ontology:DOID:1596); motor peripheral neuropathy (Disease Ontology:DOID:2477); substance abuse (Disease Ontology:DOID:302); middle cerebral artery infarction (Disease Ontology:DOID:3525)",
        "pathway": " (hsa:1959);  (R-HSA-381340);  (R-HSA-5617472);  (R-HSA-9031628);  (R-HSA-9619665)",
        "pathway_count": 5,
        "publication_count": 322,
        "publication_id_list": "10.1101/2023.09.13.557529;10075656;10203854;10220111;10371530;10381005;10400691;10425206;10502832;10611221;10611312;10656257;10727776;10734128;10757804;10762521;10777502;10826704;10856243;10872467;10882540;10984481;11018254;11027551;11095972;11115854;11133365;11157804;11237011;11239949;11280768;11331872;11343657;11356866;11394999;11430795;11430802;11567222;11734543;11755530;11782409;11840323;11872672;11956230;12056842;12145339;12198163;12213831;12399542;12511643;12736090;12782656;12799134;12829629;1377233;14512514;14522948;14532282;14597720;14664827;14969744;15102911;15150276;15161978;15189448;15241803;15273253;15356632;15449318;15542842;15610069;15620361;15695336;1570299;15733869;15836632;15850785;15867264;15880109;15907797;15919796;15947997;16034366;16079151;16136673;16187211;16221685;16260776;16287845;16311519;16319321;16339507;16373334;16380219;16407550;16484497;16549775;16574654;16732277;16923174;17011499;1704008;17088210;17088211;17088212;17185360;17325040;17428788;1756725;17632064;17660710;17699610;17713478;17717711;17761849;17851529;17898216;17959798;17980149;18056528;18088355;18160048;1833716;18456662;18524893;1861162;18634568;18781158;18803322;18931025;19043829;19061646;19115207;19115252;19116276;19143832;19156870;19172745;19193899;19194657;19232136;19321787;19651900;19745155;19747919;1975088;1975954;19782034;19854132;19922439;19926875;20085832;20101261;20149798;2017159;20213556;2040600;20506119;2052361;20625412;2072895;20832498;21044070;21057636;2109185;2111009;21326363;21411665;21423190;21423191;21486943;21613327;21621608;21653862;21836637;22053691;22065583;22180461;22302795;22333914;2237820;22492709;22522483;22546699;22569366;22705304;22734907;22764250;22814607;22879880;23219899;23239344;23481700;23534758;23630040;23695165;23747866;23874858;24060757;24174538;24191038;24227709;24312487;24586203;24646194;24675079;25101834;25135475;25248477;25569790;2570724;25748042;25913784;25974668;26018600;26154972;26423937;26441514;2676516;27041596;27128622;27220739;27288457;27846572;27859941;27920218;28076410;28121444;28275114;28286024;28832583;28852375;29242379;29351928;29393594;29508533;29559111;29632046;29748249;30843326;3127059;3140236;31844290;31852952;32157095;32387766;32938616;33912179;34087483;35051231;3672127;37474655;38165680;38679230;39298490;40499546;7488013;7501971;7551568;7592934;7595538;7608156;7624335;7777577;7823924;7831296;7857651;7871435;7876254;7906964;7908827;7923378;7925941;7935840;8090221;8090222;8138712;8248782;8325954;8349731;8413279;8483478;8576248;8583621;8619637;8627307;8643605;8647822;8662541;8668170;8674428;8706692;8756618;8759021;8770873;8842374;8846918;8918830;8970730;9032251;9065481;9084409;9218805;9272954;9343422;9390517;9418898;9418958;9454824;9482253;9482740;9537424;9622090;9705348;9722618;9748295;9770464;9774344;9808461;9822744;9836620;9858769",
        "class_list": "",
        "function": "E3 SUMO-protein ligase helping SUMO1 conjugation to its coregulators NAB1 and NAB2, whose sumoylation down-regulates EGR2 transcriptional activity., [UniProtKB, PubMed, UniProtKB, UniProtKB]; EGR2 drives TH17 cell pathogenicity in autoimmune neuroinflammation., [RefSeq, PubMed]; Early growth response protein 2 promotes partial epithelial-mesenchymal transition by phosphorylating Smad3 during renal fibrosis., [RefSeq, PubMed]; MicroRNA-150-5P regulates Th1/Th2 cytokines expression levels by targeting EGR2 in allergic rhinitis., [RefSeq, PubMed]; Sequence-specific DNA-binding transcription factor (PubMed:17717711). Plays a role in hindbrain segmentation by regulating the expression of a subset of homeobox containing genes and in Schwann cell myelination by regulating the expression of genes involved in the formation and maintenance of myelin (By similarity). Binds to two EGR2-consensus sites EGR2A (5'-CTGTAGGAG-3') and EGR2B (5'-ATGTAGGTG-3') in the HOXB3 enhancer and promotes HOXB3 transcriptional activation (By similarity). Binds to specific DNA sites located in the promoter region of HOXA4, HOXB2 and ERBB2 (By similarity). Regulates hindbrain segmentation by controlling the expression of Hox genes, such as HOXA4, HOXB3 and HOXB2, and thereby specifying odd and even rhombomeres (By similarity). Promotes the expression of HOXB3 in the rhombomere r5 in the hindbrain (By similarity). Regulates myelination in the peripheral nervous system after birth, possibly by regulating the expression of myelin proteins, such as MPZ, and by promoting the differentiation of Schwann cells (By similarity). Involved in the development of the jaw openener musculature, probably by playing a role in its innervation through trigeminal motor neurons (By similarity). May play a role in adipogenesis, possibly by regulating the expression of CEBPB (By similarity)., [UniProtKB, UniProtKB, PubMed]; The protein encoded by this gene is a transcription factor with three tandem C2H2-type zinc fingers. Defects in this gene are associated with Charcot-Marie-Tooth disease type 1D (CMT1D), Charcot-Marie-Tooth disease type 4E (CMT4E), and with Dejerine-Sottas syndrome (DSS). Multiple transcript variants encoding two different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]., [RefSeq]; Transcription factor EGR2 alleviates autoimmune uveitis via activation of GDF15 to modulate the retinal microglial phenotype., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 14,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 14,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 14,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 1,
        "reported_glycation": 0,
        "reported_snv": 39,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 3,
        "disease_count": 14,
        "glyco_site_count": 15,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R724;B3KRD7;Q68CZ5;Q8IV26;Q9UNA6",
        "ec_number_list": [
            {
                "id": "2.1.1.364",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.364",
                "type": "external"
            },
            {
                "id": "1.14.11.68",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.11.68",
                "type": "external"
            },
            {
                "id": "2.3.2.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.2.-",
                "type": "external"
            },
            {
                "id": "1.1.1.34",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.1.1.34",
                "type": "external"
            },
            {
                "id": "3.1.13.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.13.-",
                "type": "external"
            },
            {
                "id": "2.7.7.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.48",
                "type": "external"
            },
            {
                "id": "2.7.7.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.6",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "2.3.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.-",
                "type": "external"
            },
            {
                "id": "1.14.14.154",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.14.154",
                "type": "external"
            },
            {
                "id": "1.14.19.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:1.14.19.1",
                "type": "external"
            },
            {
                "id": "3.4.-.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.-.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0061665 SUMO ligase activity;GO:0003682 chromatin binding;GO:0003700 DNA-binding transcription factor activity;GO:0008270 zinc ion binding;GO:0031625 ubiquitin protein ligase binding",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0000785 chromatin",
        "go_biological_process": "GO:0006351 DNA-templated transcription;GO:0006357 regulation of transcription by RNA polymerase II;GO:0016925 protein sumoylation;GO:0045944 positive regulation of transcription by RNA polymerase II;GO:0007420 brain development",
        "synthesized_glycan_count": 0,
        "hit_score": 34.1,
        "record_id": "P11161-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P08709-1",
        "uniprot_id": [
            {
                "id": "FA7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P08709",
                "type": "external"
            }
        ],
        "mass": 51594.0,
        "length": 466,
        "protein_name": "Coagulation factor VII",
        "gene_name": "F7",
        "organism": "Human",
        "refseq_name": "coagulation factor VII isoform a preproprotein",
        "refseq_ac": [
            {
                "id": "NP_000122",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_000122",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "F7",
        "gene_names_refseq": "F7; SPCA",
        "protein_names_uniprotkb": "Coagulation factor VII; 3.4.21.21; Proconvertin; SPCA; Serum prothrombin conversion accelerator",
        "protein_names_refseq": "FVII coagulation protein; coagulation factor VII (serum prothrombin conversion accelerator); coagulation factor VII isoform a preproprotein; eptacog alfa; proconvertin",
        "tax_id": 9606,
        "disease": "acquired angioedema (Disease Ontology:DOID:0080941); hypertension (Disease Ontology:DOID:10763); familial hyperlipidemia (Disease Ontology:DOID:1168); hypothyroidism (Disease Ontology:DOID:1459); hereditary angioedema (Disease Ontology:DOID:14735); thrombocytopenia (Disease Ontology:DOID:1588); breast cancer (Disease Ontology:DOID:1612); factor VII deficiency (Disease Ontology:DOID:2215); prothrombin deficiency (Disease Ontology:DOID:2235); arteriosclerosis (Disease Ontology:DOID:2349); ovarian cancer (Disease Ontology:DOID:2394); bilirubin metabolic disorder (Disease Ontology:DOID:2741); asthma (Disease Ontology:DOID:2841); acute pancreatitis (Disease Ontology:DOID:2913); coronary artery disease (Disease Ontology:DOID:3393); cerebral infarction (Disease Ontology:DOID:3526); hyperglycemia (Disease Ontology:DOID:4195); kidney disease (Disease Ontology:DOID:557); proteinuria (Disease Ontology:DOID:576); myocardial infarction (Disease Ontology:DOID:5844); intermediate coronary syndrome (Disease Ontology:DOID:8805); diabetic retinopathy (Disease Ontology:DOID:8947); colorectal cancer (Disease Ontology:DOID:9256); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); diabetic neuropathy (Disease Ontology:DOID:9743); type 1 diabetes mellitus (Disease Ontology:DOID:9744); obesity (Disease Ontology:DOID:9970)",
        "pathway": " (hsa:2155);  (R-HSA-1368108);  (R-HSA-159740);  (R-HSA-159763);  (R-HSA-159782);  (R-HSA-9769735);  (R-HSA-9769739)",
        "pathway_count": 7,
        "publication_count": 143,
        "publication_id_list": "10026158;10068650;10391209;10862079;10917896;10984565;11018023;11035113;11091194;11129332;11162494;11237011;11238108;11241162;11252894;11513608;11833835;12052963;12130638;12406875;12472587;12738229;12907439;14672706;14717781;14982929;15500444;15560782;16161994;1618828;16292673;1634227;16619025;16857194;17506785;17598008;17635713;18587630;18642129;1874730;18976247;1902833;1904059;19167329;19297154;1930190;19432927;19710929;19751712;2040636;20427285;2070047;21206266;2129367;21372693;21932952;21949356;22144186;2248955;22618708;22652793;2271516;22786881;23006890;23090970;23621622;23683607;2384594;24554904;24715725;2511201;2538457;25713144;25753038;25855704;2664828;26761581;2704749;271951;2738071;27501279;29419409;29437578;29557506;2991279;3037537;3052293;30918026;31003762;31262782;31439947;3264725;3275472;34502392;3486420;3527261;35580925;36951360;36951953;37074911;3744129;37726033;37925034;37993374;38335567;3863104;38926980;38926981;6323392;6967872;6980899;7499257;7860081;7974346;7981125;7981691;8043443;8144529;8204879;8242057;8244334;8336730;8364544;8473289;8530480;8578528;8598903;8618898;8639673;8639781;8652821;8844208;8883260;8940045;9023546;9218519;9414278;9452082;9459334;9469622;9576180;9692950;9925787",
        "class_list": "",
        "function": "Acquired factor VII deficiency in pediatric inflammatory bowel disease: Report of three cases., [RefSeq, PubMed]; Frequency of the p.Thr241Asn mutation in Chinese patients with congenital factor VII deficiency., [RefSeq, PubMed]; Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa also converts factor IX to factor IXa in the presence of tissue factor and calcium (PubMed:271951)., [UniProtKB, PubMed, UniProtKB, UniProtKB]; This gene encodes coagulation factor VII which is a vitamin K-dependent factor essential for hemostasis. This factor circulates in the blood in a zymogen form, and is converted to an active form by either factor IXa, factor Xa, factor XIIa, or thrombin by minor proteolysis. Upon activation of the factor VII, a heavy chain containing a catalytic domain and a light chain containing 2 EGF-like domains are generated, and two chains are held together by a disulfide bond. In the presence of factor III and calcium ions, the activated factor then further activates the coagulation cascade by converting factor IX to factor IXa and/or factor X to factor Xa. Defects in this gene can cause coagulopathy. Alternative splicing results in multiple transcript variants encoding different isoforms that may undergo similar proteolytic processing to generate mature polypeptides. [provided by RefSeq, Aug 2015]., [RefSeq]; [Congenital F Deficiency Associated with a Novel Mutation in F7 Gene]., [RefSeq, PubMed]; [Pedigree Analysis of Hereditary Coagulation Factor XII Deficiency Caused by Compound Heterozygous Mutation p.Gly175Cys and p.Gly542Ser of F12 Gene]., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 2,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 3,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 18,
        "disease_count": 28,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B0YJC8;Q14339;Q5JVF1;Q5JVF2;Q9UD52;Q9UD53;Q9UD54",
        "ec_number_list": [
            {
                "id": "2.3.1.48",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.3.1.48",
                "type": "external"
            },
            {
                "id": "3.4.21.22",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.22",
                "type": "external"
            },
            {
                "id": "3.4.21.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.6",
                "type": "external"
            },
            {
                "id": "3.4.21.21",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.21",
                "type": "external"
            },
            {
                "id": "3.4.21.75",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.21.75",
                "type": "external"
            },
            {
                "id": "4.1.1.90",
                "url": "https://www.rhea-db.org/rhea/?query=ec:4.1.1.90",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004252 serine-type endopeptidase activity;GO:0005102 signaling receptor binding;GO:0005509 calcium ion binding;GO:0008236 serine-type peptidase activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005788 endoplasmic reticulum lumen;GO:0005796 Golgi lumen;GO:0005886 plasma membrane",
        "go_biological_process": "GO:0097068 response to thyroxine;GO:0016485 protein processing;GO:0030335 positive regulation of cell migration;GO:0001666 response to hypoxia;GO:0007596 blood coagulation",
        "synthesized_glycan_count": 0,
        "hit_score": 16.7,
        "record_id": "P08709-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.1100000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C7A2-1",
        "uniprot_id": [
            {
                "id": "F153B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C7A2",
                "type": "external"
            }
        ],
        "mass": 43591.0,
        "length": 387,
        "protein_name": "Protein FAM153B",
        "gene_name": "FAM153B",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "FAM153B",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Protein FAM153B",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
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        "class_list": "",
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "secondary_ac_list": "A8MTI1",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "P0C7A2-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000001000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15717-1",
        "uniprot_id": [
            {
                "id": "ELAV1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15717",
                "type": "external"
            }
        ],
        "mass": 36092.0,
        "length": 326,
        "protein_name": "ELAV-like protein 1",
        "gene_name": "ELAVL1",
        "organism": "Human",
        "refseq_name": "ELAV-like protein 1",
        "refseq_ac": [
            {
                "id": "NP_001410",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001410",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ELAVL1; HUR",
        "gene_names_refseq": "ELAV1; ELAVL1; HUR; Hua; MelG",
        "protein_names_uniprotkb": "ELAV-like protein 1; Hu-antigen R; HuR",
        "protein_names_refseq": "ELAV (embryonic lethal, abnormal vision, Drosophila)-like 1 (Hu antigen R); ELAV-like protein 1; Hu antigen R; Human antigen R; embryonic lethal, abnormal vision, drosophila, homolog-like 1; hu-antigen R",
        "tax_id": 9606,
        "disease": "degenerative disc disease (Disease Ontology:DOID:90)",
        "pathway": " (hsa:1994);  (R-HSA-450520);  (R-HSA-9918481)",
        "pathway_count": 3,
        "publication_count": 190,
        "publication_id_list": "10228016;11018049;11237011;11559817;11729309;11747608;11834731;12237300;12816978;14517288;14519844;14654843;14731398;14762106;14981256;15084397;15257295;15592455;16484227;17081983;17178712;17317627;17322306;17392515;17517897;17632515;17924679;17932509;18161049;18191643;18220336;18285462;18593881;18669648;18767875;18927508;18948743;19029303;19130553;19528229;19561594;19651622;19664995;19690332;20068231;20086103;20219472;20305658;21310943;21406692;21740066;21862584;21884634;21911577;22121020;22544926;22829587;23115237;23186163;23301498;23481700;23519412;23640942;23921630;23978401;24106086;24129315;24416409;24492650;24715725;24865968;25418920;25469497;25576301;25645385;25810538;25880248;26092250;26154972;26375851;26768311;26811146;26992070;27108190;27303922;27600516;27616329;27846572;27862975;27920218;28063628;28218747;28228285;28510447;28649982;28832583;28834231;28860189;28904123;29180010;29242379;29393594;29476152;29493099;29508533;29557506;29563610;29632046;29632711;29786170;29789417;29902443;30067974;30091833;30154469;30315122;30429286;30524438;30599162;30779550;31092671;31154438;31217245;31222486;31358969;31530632;31844290;31848261;31937595;31998317;32047552;32157095;32161166;32245947;32265295;32350084;32357974;32387766;32413989;32488085;32502341;32897882;32938616;32983136;33091337;33141586;33177556;33214551;33298915;33537174;33592498;33633747;33691108;33717175;33912179;33936100;33968037;33981976;34019948;34078123;34087483;34171305;34211107;34229054;34405274;34433824;34509645;34725712;34932366;35051231;35083852;35215846;35251023;35318648;35561310;35580925;36010968;36215666;36241641;36284347;37938771;38608448;38665916;38748875;38965208;39265220;39390359;39534244;40914422;8626503",
        "class_list": "",
        "function": "ELAVL1 regulates PD-L1 mRNA stability to disrupt the infiltration of CD4-positive T cells in prostate cancer., [RefSeq, PubMed]; ELAVL1 regulates glycolysis in nasopharyngeal carcinoma cells through the HMGB3/beta-catenin axis. Publication Status: Online-Only, [RefSeq, PubMed]; HuR controls glutaminase RNA metabolism. Publication Status: Online-Only, [RefSeq, PubMed]; HuR promotes triglyceride synthesis and intestinal fat absorption., [RefSeq, PubMed]; RNA-binding protein that binds to the 3'-UTR region of mRNAs and increases their stability (PubMed:14517288, PubMed:18285462, PubMed:31358969). Involved in embryonic stem cell (ESC) differentiation: preferentially binds mRNAs that are not methylated by N6-methyladenosine (m6A), stabilizing them, promoting ESC differentiation (By similarity). Has also been shown to be capable of binding to m6A-containing mRNAs and contributes to MYC stability by binding to m6A-containing MYC mRNAs (PubMed:32245947). Binds to poly-U elements and AU-rich elements (AREs) in the 3'-UTR of target mRNAs (PubMed:14731398, PubMed:17632515, PubMed:18285462, PubMed:23519412, PubMed:8626503). Binds avidly to the AU-rich element in FOS and IL3/interleukin-3 mRNAs. In the case of the FOS AU-rich element, binds to a core element of 27 nucleotides that contain AUUUA, AUUUUA, and AUUUUUA motifs. Binds preferentially to the 5'-UUUU[AG]UUU-3' motif in vitro (PubMed:8626503). With ZNF385A, binds the 3'-UTR of p53/TP53 mRNA to control their nuclear export induced by CDKN2A. Hence, may regulate p53/TP53 expression and mediate in part the CDKN2A anti-proliferative activity. May also bind with ZNF385A the CCNB1 mRNA (By similarity). Increases the stability of the leptin mRNA harboring an AU-rich element (ARE) in its 3' UTR (PubMed:29180010)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; STAT3 promotes cytoplasmic-nuclear translocation of RNA-binding protein HuR to inhibit IL-1beta-induced IL-8 production., [RefSeq, PubMed]; The protein encoded by this gene is a member of the ELAVL family of RNA-binding proteins that contain several RNA recognition motifs, and selectively bind AU-rich elements (AREs) found in the 3' untranslated regions of mRNAs. AREs signal degradation of mRNAs as a means to regulate gene expression, thus by binding AREs, the ELAVL family of proteins play a role in stabilizing ARE-containing mRNAs. This gene has been implicated in a variety of biological processes and has been linked to a number of diseases, including cancer. It is highly expressed in many cancers, and could be potentially useful in cancer diagnosis, prognosis, and therapy. [provided by RefSeq, Sep 2012]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 19,
        "reported_mutagensis": 3,
        "reported_glycation": 0,
        "reported_snv": 14,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B4DVB8;Q53XN6;Q9BTT1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0003729 mRNA binding;GO:0019901 protein kinase binding;GO:0042803 protein homodimerization activity;GO:0003725 double-stranded RNA binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0060965 negative regulation of miRNA-mediated gene silencing;GO:0008283 cell population proliferation;GO:0032930 positive regulation of superoxide anion generation;GO:0048255 mRNA stabilization;GO:0051260 protein homooligomerization",
        "synthesized_glycan_count": 0,
        "hit_score": 19.3,
        "record_id": "Q15717-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P13726-1",
        "uniprot_id": [
            {
                "id": "TF_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P13726",
                "type": "external"
            }
        ],
        "mass": 33068.0,
        "length": 295,
        "protein_name": "Tissue factor",
        "gene_name": "F3",
        "organism": "Human",
        "refseq_name": "tissue factor isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001171567",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001171567",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "F3",
        "gene_names_refseq": "CD142; F3; TFA; TF",
        "protein_names_uniprotkb": "Tissue factor; Coagulation factor III; TF; Thromboplastin",
        "protein_names_refseq": "coagulation factor III (thromboplastin, tissue factor); tissue factor isoform 2 precursor",
        "tax_id": 9606,
        "disease": "idiopathic pulmonary fibrosis (Disease Ontology:DOID:0050156); acute promyelocytic leukemia (Disease Ontology:DOID:0060318); thrombosis (Disease Ontology:DOID:0060903); Brunet-Wagner neurodevelopmental syndrome (Disease Ontology:DOID:0061126); myeloid neoplasm (Disease Ontology:DOID:0070004); COVID-19 (Disease Ontology:DOID:0080600); B-lymphoblastic leukemia/lymphoma (Disease Ontology:DOID:0080630); graft-versus-host disease (Disease Ontology:DOID:0081267); preterm premature rupture of the membranes (Disease Ontology:DOID:0111144); prostate cancer (Disease Ontology:DOID:10283); intellectual disability (Disease Ontology:DOID:1059); pre-eclampsia (Disease Ontology:DOID:10591); hypertension (Disease Ontology:DOID:10763); sickle cell anemia (Disease Ontology:DOID:10923); disseminated intravascular coagulation (Disease Ontology:DOID:11247); adult respiratory distress syndrome (Disease Ontology:DOID:11394); familial hyperlipidemia (Disease Ontology:DOID:1168); diabetic angiopathy (Disease Ontology:DOID:11713); von Willebrand's disease (Disease Ontology:DOID:12531); cancer (Disease Ontology:DOID:162); acute pancreatitis (Disease Ontology:DOID:2913); carotid artery thrombosis (Disease Ontology:DOID:3410); bile duct disease (Disease Ontology:DOID:4138); liver cirrhosis (Disease Ontology:DOID:5082); ovarian hyperstimulation syndrome (Disease Ontology:DOID:5425); myocardial infarction (Disease Ontology:DOID:5844); diabetic retinopathy (Disease Ontology:DOID:8947); acute myeloid leukemia (Disease Ontology:DOID:9119); diabetes mellitus (Disease Ontology:DOID:9351); type 2 diabetes mellitus (Disease Ontology:DOID:9352); acute lymphoblastic leukemia (Disease Ontology:DOID:9952)",
        "pathway": " (hsa:2152);  (R-HSA-9031628);  (R-HSA-9769735);  (R-HSA-9769739)",
        "pathway_count": 4,
        "publication_count": 223,
        "publication_id_list": "10.1101/2023.09.13.557529;10026158;10203854;10381005;10611221;10611312;10656257;10734128;10826704;10872467;10882540;10984481;11018254;11027551;11035113;11238108;11280768;11331872;11343657;11567222;11755530;11833835;11840323;11956230;12052963;12399542;12511643;12652293;12907439;1377233;14522948;14597720;14969744;14982929;15102911;15161978;15449318;15542842;15620361;1570299;15733869;15836632;15880109;16034366;16136673;16161994;16187211;1618828;16221685;16260776;16287845;16339507;16407550;16484497;16574654;16619025;16732277;17088210;17088211;17088212;1740409;17506785;17598008;17632064;17635713;17898216;18056528;18088355;18160048;1833716;18456662;18524893;1861162;1874730;1902833;19061646;19116276;19168442;19193899;19194657;19297154;1930190;19623180;19926875;2017159;2040600;2040636;20427285;20506119;2052361;20634491;2072895;21057636;2109185;21326363;21486943;21621608;21932952;22053691;22065583;22144186;22302795;2237820;2248955;22618708;22652793;2271516;22786881;23006890;23090970;23195225;23621622;23683607;2384594;24060757;24190977;24554904;25248477;2538457;25569790;25713144;25748042;25855704;26018600;2676516;27041596;2704749;27128622;271951;2719931;27220739;27452731;28076410;2823875;28275114;28286024;29242379;29419409;29437578;29557506;29559111;29741879;29789417;3037536;3052293;30918026;31003762;31020640;31262782;3127059;31439947;3166978;31844290;3275472;3297348;32983136;33043033;33592498;33968037;3424286;34321228;35051231;3527261;35580925;36284347;3672127;36951953;37074911;3744129;37589138;37726033;37925034;38069209;38191673;3863104;6323392;6980899;7499257;7551568;7592934;7595538;7608156;7624335;7777577;7823924;7857651;7871435;7876254;7923378;8086403;8090221;8090222;8144529;8248782;8413279;8483478;8576248;8578528;8583621;8598903;8609606;8639673;8639781;8668170;8756618;8846918;8918830;9032251;9084409;9218519;9343422;9390517;9418898;9459334;9469622;9622090;9722618;9770464;9774344;9808461;9822744;9858769;9925787",
        "class_list": "",
        "function": "Cell Surface Platelet Tissue Factor Expression: Regulation by P2Y12 and Link to Residual Platelet Reactivity., [RefSeq, PubMed]; Expression of Tissue Factor and Platelet/Leukocyte Markers on Extracellular Vesicles Reflect Platelet-Leukocyte Interaction in Severe COVID-19. Publication Status: Online-Only, [RefSeq, PubMed]; Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade., [UniProtKB, PubMed, PubMed]; This gene encodes coagulation factor III which is a cell surface glycoprotein. This factor enables cells to initiate the blood coagulation cascades, and it functions as the high-affinity receptor for the coagulation factor VII. The resulting complex provides a catalytic event that is responsible for initiation of the coagulation protease cascades by specific limited proteolysis. Unlike the other cofactors of these protease cascades, which circulate as nonfunctional precursors, this factor is a potent initiator that is fully functional when expressed on cell surfaces, for example, on monocytes. There are 3 distinct domains of this factor: extracellular, transmembrane, and cytoplasmic. Platelets and monocytes have been shown to express this coagulation factor under procoagulatory and proinflammatory stimuli, and a major role in HIV-associated coagulopathy has been described. Platelet-dependent monocyte expression of coagulation factor III has been described to be associated with Coronavirus Disease 2019 (COVID-19) severity and mortality. This protein is the only one in the coagulation pathway for which a congenital deficiency has not been described. Alternate splicing results in multiple transcript variants.[provided by RefSeq, Aug 2020]., [RefSeq]; Tissue factor overexpression promotes resistance to KRAS-G12C inhibition in non-small cell lung cancer., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 8818,
        "biomarker_type": "diagnostic",
        "glycan_count": 9,
        "disease_count": 31,
        "glyco_site_count": 2,
        "binding_glycan_count": 0,
        "secondary_ac_list": "D3DT47;Q6FHG2;Q86WH4",
        "ec_number_list": [],
        "go_molecular_function": "GO:0002020 protease binding;GO:0005543 phospholipid binding;GO:0004896 cytokine receptor activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0009986 cell surface;GO:0016020 membrane;GO:0031012 extracellular matrix",
        "go_biological_process": "GO:0010628 positive regulation of gene expression;GO:0016485 protein processing;GO:0030335 positive regulation of cell migration;GO:0007596 blood coagulation;GO:0045766 positive regulation of angiogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 23.5,
        "record_id": "P13726-1",
        "record_type": "protein",
        "filter_code": "1000000.1000111.100000.000000000001000000.1000000000001.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q7Z5A7-1",
        "uniprot_id": [
            {
                "id": "TAFA5_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q7Z5A7",
                "type": "external"
            }
        ],
        "mass": 14301.0,
        "length": 132,
        "protein_name": "Chemokine-like protein TAFA-5",
        "gene_name": "TAFA5",
        "organism": "Human",
        "refseq_name": "chemokine-like protein TAFA-5 isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001076436",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001076436",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "TAFA5; FAM19A5; PRO34524",
        "gene_names_refseq": "FAM19A5; QLLK5208; TAFA-5; TAFA5; UNQ5208",
        "protein_names_uniprotkb": "Chemokine-like protein TAFA-5",
        "protein_names_refseq": "TAFA protein 5; chemokine-like protein TAFA-5 isoform 1 precursor; chemokine-like protein TAFA-5; family with sequence similarity 19 (chemokine (C-C motif)-like), member A5; family with sequence similarity 19 member A5, C-C motif chemokine like; protein FAM19A5",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25817)",
        "pathway_count": 1,
        "publication_count": 10,
        "publication_id_list": "11237011;12975309;15028294;18477386;29453251;32831973;33685344;34344333;35282278;35793765",
        "class_list": "",
        "function": "Acts as a chemokine-like protein by regulating cell proliferation and migration through activation of G protein-coupled receptors (GPCRs), such as S1PR2 and FPR2 (By similarity). Stimulates chemotactic migration of macrophages mediated by the MAPK3/ERK1 and AKT1 pathway (By similarity). Blocks TNFSF11/RANKL-induced osteoclast formation from macrophages by inhibiting up-regulation of osteoclast fusogenic and differentiation genes (By similarity). Stimulation of macrophage migration and inhibition of osteoclast formation is mediated via GPCR FPR2 (By similarity). Acts as an adipokine by negatively regulating vascular smooth muscle cell (VSMC) proliferation and migration in response to platelet-derived growth factor stimulation via GPCR S1PR2 and G protein GNA12/GNA13-transmitted RHOA signaling (By similarity). Inhibits injury-induced cell proliferation and neointima formation in the femoral arteries (By similarity)., [UniProtKB, UniProtKB, UniProtKB]; Assessment of progranulin and FAM19A5 protein blood levels in patients with metabolic syndrome., [RefSeq, PubMed]; Association of Serum FAM19A5 with Cognitive Impairment in Vascular Dementia. Publication Status: Online-Only, [RefSeq, PubMed]; Circulating levels of FAM19A5 are inversely associated with subclinical atherosclerosis in non-alcoholic fatty liver disease. Publication Status: Online-Only, [RefSeq, PubMed]; FAM19A5/S1PR1 signaling pathway regulates the viability and proliferation of mantle cell lymphoma., [RefSeq, PubMed]; Increased level of FAM19A5 is associated with cerebral small vessel disease and leads to a better outcome. Publication Status: Online-Only, [RefSeq, PubMed]; This gene is a member of the TAFA family which is composed of five highly homologous genes that encode small secreted proteins. These proteins contain conserved cysteine residues at fixed positions, and are distantly related to MIP-1alpha, a member of the CC-chemokine family. The TAFA proteins are predominantly expressed in specific regions of the brain, and are postulated to function as brain-specific chemokines or neurokines that act as regulators of immune and nervous cells. [provided by RefSeq, Sep 2013]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 10,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NII9;B0QZ13;B0QZ14;B0QZ15;O95902;Q5H9C4;Q6UWC9;Q8IXR8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001664 G protein-coupled receptor binding;GO:0005125 cytokine activity;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0005737 cytoplasm",
        "go_biological_process": "GO:0007186 G protein-coupled receptor signaling pathway;GO:1904706 negative regulation of vascular associated smooth muscle cell proliferation",
        "synthesized_glycan_count": 0,
        "hit_score": 1.1,
        "record_id": "Q7Z5A7-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O14944-1",
        "uniprot_id": [
            {
                "id": "EREG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O14944",
                "type": "external"
            }
        ],
        "mass": 19044.0,
        "length": 169,
        "protein_name": "Proepiregulin",
        "gene_name": "EREG",
        "organism": "Human",
        "refseq_name": "proepiregulin preproprotein",
        "refseq_ac": [
            {
                "id": "NP_001423",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001423",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EREG",
        "gene_names_refseq": "EPR; EREG; ER; Ep",
        "protein_names_uniprotkb": "Proepiregulin",
        "protein_names_refseq": "proepiregulin preproprotein; proepiregulin",
        "tax_id": 9606,
        "disease": "extrapulmonary tuberculosis (Disease Ontology:DOID:0050598); ductal carcinoma in situ (Disease Ontology:DOID:0060074); endometrial hyperplasia (Disease Ontology:DOID:0080365); prostate cancer (Disease Ontology:DOID:10283); hypertension (Disease Ontology:DOID:10763); nephritis (Disease Ontology:DOID:10952); leiomyoma (Disease Ontology:DOID:127); endometrial carcinoma (Disease Ontology:DOID:2871); endometriosis (Disease Ontology:DOID:289); cervix carcinoma (Disease Ontology:DOID:2893); pulmonary tuberculosis (Disease Ontology:DOID:2957); ischemia (Disease Ontology:DOID:326); lung squamous cell carcinoma (Disease Ontology:DOID:3907); tuberculosis (Disease Ontology:DOID:399); ovarian carcinoma (Disease Ontology:DOID:4001); cervical cancer (Disease Ontology:DOID:4362); uremia (Disease Ontology:DOID:4676); lung small cell carcinoma (Disease Ontology:DOID:5409); pulmonary hypertension (Disease Ontology:DOID:6432); hepatocellular carcinoma (Disease Ontology:DOID:684); cholesteatoma (Disease Ontology:DOID:869)",
        "pathway": " (hsa:2069);  (R-HSA-1227986);  (R-HSA-1236394);  (R-HSA-1250196);  (R-HSA-1250342);  (R-HSA-1250347);  (R-HSA-1251985);  (R-HSA-1257604);  (R-HSA-177929);  (R-HSA-179812);  (R-HSA-180292);  (R-HSA-180336);  (R-HSA-182971);  (R-HSA-1963640);  (R-HSA-1963642);  (R-HSA-212718);  (R-HSA-2219530);  (R-HSA-5638303);  (R-HSA-5673001);  (R-HSA-6785631);  (R-HSA-6811558);  (R-HSA-8847993);  (R-HSA-8856825);  (R-HSA-8856828);  (R-HSA-8863795);  (R-HSA-9009391);  (R-HSA-9634638);  (R-HSA-9664565);  (R-HSA-9665686)",
        "pathway_count": 29,
        "publication_count": 564,
        "publication_id_list": 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        "class_list": "",
        "function": "IGF2BP2 promotes cell invasion and epithelial-mesenchymal transition through Src-mediated upregulation of EREG in oral cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Ligand of the EGF receptor/EGFR and ERBB4. Stimulates EGFR and ERBB4 tyrosine phosphorylation (PubMed:9419975). Contributes to inflammation, wound healing, tissue repair, and oocyte maturation by regulating angiogenesis and vascular remodeling and by stimulating cell proliferation (PubMed:24631357)., [UniProtKB, PubMed, PubMed]; MicroRNA-1179 targets Epiregulin (EREG) regulates the proliferation and metastasis of human multiple myeloma cells., [RefSeq, PubMed]; Stabilization of EREG via STT3B-mediated N-glycosylation is critical for PDL1 upregulation and immune evasion in head and neck squamous cell carcinoma. Publication Status: Online-Only, [RefSeq, PubMed]; The growth factor EPIREGULIN promotes basal progenitor cell proliferation in the developing neocortex., [RefSeq, PubMed]; This gene encodes a secreted peptide hormone and member of the epidermal growth factor (EGF) family of proteins. The encoded protein is a ligand of the epidermal growth factor receptor (EGFR) and the structurally related erb-b2 receptor tyrosine kinase 4 (ERBB4). The encoded protein may be involved in a wide range of biological processes including inflammation, wound healing, oocyte maturation, and cell proliferation. Additionally, the encoded protein may promote the progression of cancers of various human tissues. [provided by RefSeq, Jul 2015]., [RefSeq]; Two Cases of Biphasic Synovial Sarcoma With Expression of PAX8 and ER: A Diagnostic Pitfall., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "mined_glycosites": 1,
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        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
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        "total_reported_s_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
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        "reported_snv": 5,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 21,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RC66;Q6FH69",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005154 epidermal growth factor receptor binding;GO:0008083 growth factor activity;GO:0030297 transmembrane receptor protein tyrosine kinase activator activity;GO:0048018 receptor ligand activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0030669 clathrin-coated endocytic vesicle membrane",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0007267 cell-cell signaling;GO:0008284 positive regulation of cell population proliferation;GO:0008285 negative regulation of cell population proliferation;GO:0032755 positive regulation of interleukin-6 production",
        "synthesized_glycan_count": 0,
        "hit_score": 56.6,
        "record_id": "O14944-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000100000000.110.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0DMC3-1",
        "uniprot_id": [
            {
                "id": "ELA_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0DMC3",
                "type": "external"
            }
        ],
        "mass": 6622.0,
        "length": 54,
        "protein_name": "Apelin receptor early endogenous ligand",
        "gene_name": "APELA",
        "organism": "Human",
        "refseq_name": "apelin receptor early endogenous ligand precursor",
        "refseq_ac": [
            {
                "id": "NP_001284479",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001284479",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "APELA; ELA; TDL",
        "gene_names_refseq": "APELA; ELA; Ende; tdl",
        "protein_names_uniprotkb": "Apelin receptor early endogenous ligand; ELA; Protein Elabela; Protein Toddler",
        "protein_names_refseq": "apelin receptor early endogenous ligand precursor; protein Elabela; protein Toddler",
        "tax_id": 9606,
        "disease": "pre-eclampsia (Disease Ontology:DOID:10591)",
        "pathway": " (hsa:100506013)",
        "pathway_count": 1,
        "publication_count": 9,
        "publication_id_list": "24316148;25639753;28137936;28663440;35817871;36669444;36825397;37062502;37562237",
        "class_list": "",
        "function": "Apelin/ELABELA-APJ system in cardiac hypertrophy: Regulatory mechanisms and therapeutic potential. Review article, [RefSeq, PubMed]; Betatrophin, elabela, asprosin, glucagon and subfatin peptides in breast tissue, blood and milk in gestational diabetes., [RefSeq, PubMed]; Peptide hormone that functions as endogenous ligand for the G protein-coupled apelin receptor (APLNR/APJ), that plays a role in the regulation of normal cardiovascular function and fluid homeostasis (PubMed:25639753, PubMed:28137936, PubMed:35817871). Functions as a balanced agonist activating both G(i) protein pathway and beta-arrestin pathway of APLNR (PubMed:35817871). Downstream G proteins activation, apelin can inhibit cAMP production and activate key intracellular effectors such as ERKs (PubMed:35817871). On the other hand, APLNR activation induces beta-arrestin recruitment to the membrane leading to desensitization and internalization of the receptor (PubMed:35817871). Required for mesendodermal differentiation, blood vessels formation and heart morphogenesis during early development and for adult cardiovascular homeostasis (PubMed:25639753, PubMed:28137936). Acts as a motogen by promoting mesendodermal cell migration during gastrulation by binding and activating APLNR. Acts as an early embryonic regulator of cellular movement with a role in migration and development of cardiac progenitor cells. May act as a chemoattractant for the activation of angioblast migration toward the embryonic midline, i.e. the position of the future vessel formation, during vasculogenesis. Positively regulates sinus venosus (SV)-derived endothelial cells migration into the developing heart to promote coronary blood vessel sprouting. Plays a role in placental vascular development; promotes placental trophoblast invasion and spiral artery remodeling in the uterus. Involved in the regulation of maternal cardiovascular homeostasis to prevent gestational hypertension and for potent cardioprotective functions during heart failure. Mediates myocardial contractility in an ERK1/2-dependent manner (By similarity)., [UniProtKB, UniProtKB, PubMed, UniProtKB, UniProtKB, PubMed, PubMed]; Reduced Apela/APJ system expression in patients with pulmonary artery hypertension secondary to chronic obstructive pulmonary disease., [RefSeq, PubMed]; Therapeutic potential of apelin and Elabela in cardiovascular disease. Review article, [RefSeq, PubMed]; This gene encodes a peptide hormone that binds to the Apelin receptor. The encoded protein is required for heart development in zebrafish and has been shown to maintain self-renewal of human embryonic stem cells through activation of the PI3K/AKT pathway. Experiments in human and mouse cell lines point to additional roles for the encoded protein in angiogenesis and regulation of vascular tone. [provided by RefSeq, Jul 2016]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005179 hormone activity;GO:0031704 apelin receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0001525 angiogenesis;GO:0001570 vasculogenesis;GO:0007186 G protein-coupled receptor signaling pathway;GO:0007507 heart development;GO:0070374 positive regulation of ERK1 and ERK2 cascade",
        "synthesized_glycan_count": 0,
        "hit_score": 1.0,
        "record_id": "P0DMC3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P19957-1",
        "uniprot_id": [
            {
                "id": "ELAF_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P19957",
                "type": "external"
            }
        ],
        "mass": 12270.0,
        "length": 117,
        "protein_name": "Elafin",
        "gene_name": "PI3",
        "organism": "Human",
        "refseq_name": "elafin preproprotein",
        "refseq_ac": [
            {
                "id": "NP_002629",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_002629",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "PI3; WAP3; WFDC14",
        "gene_names_refseq": "ESI; PI3; SKALP; WAP3; WFDC14; cementoin",
        "protein_names_uniprotkb": "Elafin; ESI; Elastase-specific inhibitor; PI-3; Peptidase inhibitor 3; Protease inhibitor WAP3; SKALP; Skin-derived antileukoproteinase; WAP four-disulfide core domain protein 14",
        "protein_names_refseq": "PI-3; WAP four-disulfide core domain 14; WAP four-disulfide core domain protein 14; elafin preproprotein; elastase-specific inhibitor; peptidase inhibitor 3, skin-derived; pre-elafin; protease inhibitor 3, skin-derived (SKALP); protease inhibitor WAP3; skin-derived antileukoproteinase; trappin-2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:5266);  (R-HSA-6803157);  (R-HSA-6809371)",
        "pathway_count": 3,
        "publication_count": 117,
        "publication_id_list": "10066784;10196183;10231017;10411887;10588656;10771479;11120840;11313366;11350120;11380615;11389039;11590230;11971875;12493837;12902340;1339270;13816;14506276;14739326;15033990;1522221;15229136;15337775;1536690;15778384;15797384;15803139;15826377;15956276;16054449;16061697;16215847;16336202;16354652;16354654;16374474;16639001;16799473;16931762;16940129;17363965;17502600;17515931;17562024;17567961;17596512;17964057;18021746;18160480;18185531;18673279;18843291;19095652;19179970;19190773;19194479;19254208;19818633;19906197;2001428;20103720;20179351;20180804;20382864;20395631;2039600;20510021;20657595;20667819;20845358;20940292;21439340;21654840;21787330;21997417;22262861;22327069;22455996;22701042;23302724;23426625;23629652;2394696;24219363;24256734;25075772;25461571;25596890;25926655;26148048;26375851;26390218;27089320;29483648;29557506;31154438;32157095;32485443;32764517;3286634;33271565;33679728;34181952;34932366;35580925;7543090;7685029;8476637;8794736;8824274;8999895;9171290;9395522;9523110;9565599;9665269;9756476",
        "class_list": "",
        "function": "Elafin as a Predictive Biomarker of Acute Skin Graft-Versus-Host Disease After Haploidentical Stem Cell Transplantation Using Post-Transplant High-Dose Cyclophosphamide. Publication Status: Online-Only, [RefSeq, PubMed]; Evaluation of Elafin Immunohistochemical Expression as Marker of Cervical Cancer Severity., [RefSeq, PubMed]; Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis Vulgaris. Publication Status: Online-Only, [RefSeq, PubMed]; Neutrophil and pancreatic elastase-specific inhibitor of skin. It may prevent elastase-mediated tissue proteolysis. Has been shown to inhibit the alpha-4-beta-2/CHRNA2-CHRNB2 nicotinic acetylcholine receptor and to produce a weak inhibition on Kv11.1/KCNH2/ERG1 and on the transient receptor potential cation channel subfamily V member 1 (TRPV1) (PubMed:29483648)., [UniProtKB, PubMed]; Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency., [RefSeq, PubMed]; The synthesis of elafin is a novel effector function of gammadelta T cells which might be important for local immune defence GeneRIF: Elafin has important roles in normal homoeostasis and at sites of inflammation.  These roles include antiprotease and antimicrobial activity., [RefSeq, PubMed]; This gene encodes an elastase-specific inhibitor that functions as an antimicrobial peptide against Gram-positive and Gram-negative bacteria, and fungal pathogens. The protein contains a WAP-type four-disulfide core (WFDC) domain, and is thus a member of the WFDC domain family. Most WFDC gene members are localized to chromosome 20q12-q13 in two clusters: centromeric and telomeric. This gene belongs to the centromeric cluster. Expression of this gene is upgulated by bacterial lipopolysaccharides and cytokines. [provided by RefSeq, Oct 2014]., [RefSeq]; Upregulation of elafin expression in the fallopian tube of ectopic tubal pregnancies compared to the normal tubes., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "E1P618;Q6FG74",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004867 serine-type endopeptidase inhibitor activity;GO:0004866 endopeptidase inhibitor activity;GO:0030280 structural constituent of skin epidermis",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0005829 cytosol;GO:0031012 extracellular matrix;GO:0001533 cornified envelope",
        "go_biological_process": "GO:0019731 antibacterial humoral response;GO:0045087 innate immune response;GO:0070268 cornification;GO:0007620 copulation",
        "synthesized_glycan_count": 0,
        "hit_score": 11.8,
        "record_id": "P19957-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P20800-1",
        "uniprot_id": [
            {
                "id": "EDN2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P20800",
                "type": "external"
            }
        ],
        "mass": 19960.0,
        "length": 178,
        "protein_name": "Endothelin-2",
        "gene_name": "EDN2",
        "organism": "Human",
        "refseq_name": "endothelin-2 isoform 2 preproprotein",
        "refseq_ac": [
            {
                "id": "NP_001289198",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001289198",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EDN2",
        "gene_names_refseq": "EDN2; ET-2; ET2; PPET2",
        "protein_names_uniprotkb": "Endothelin-2; ET-2; PPET2; Preproendothelin-2",
        "protein_names_refseq": "endothelin-2 isoform 2 preproprotein; preproendothelin 2",
        "tax_id": 9606,
        "disease": "congenital hypothyroidism (Disease Ontology:DOID:0050328); alcohol dependence (Disease Ontology:DOID:0050741); diabetic encephalopathy (Disease Ontology:DOID:0050850); chronic pancreatitis (Disease Ontology:DOID:0051065); Parkinsonism (Disease Ontology:DOID:0080855); Hirschsprung's disease (Disease Ontology:DOID:10487); pre-eclampsia (Disease Ontology:DOID:10591); Alzheimer's disease (Disease Ontology:DOID:10652); portal hypertension (Disease Ontology:DOID:10762); hypertension (Disease Ontology:DOID:10763); sciatic neuropathy (Disease Ontology:DOID:11446); polycystic ovary syndrome (Disease Ontology:DOID:11612); Lewy body dementia (Disease Ontology:DOID:12217); respiratory syncytial virus infectious disease (Disease Ontology:DOID:1273); Huntington's disease (Disease Ontology:DOID:12858); dementia (Disease Ontology:DOID:1307); Parkinson's disease (Disease Ontology:DOID:14330); urticaria (Disease Ontology:DOID:1555); depressive disorder (Disease Ontology:DOID:1596); cystitis (Disease Ontology:DOID:1679); glaucoma (Disease Ontology:DOID:1686); pancreatic cancer (Disease Ontology:DOID:1793); atherosclerosis (Disease Ontology:DOID:1936); transient cerebral ischemia (Disease Ontology:DOID:224); multiple sclerosis (Disease Ontology:DOID:2377); atopic dermatitis (Disease Ontology:DOID:3310); coronary artery disease (Disease Ontology:DOID:3393); middle cerebral artery infarction (Disease Ontology:DOID:3525); rhinitis (Disease Ontology:DOID:4483); myocardial infarction (Disease Ontology:DOID:5844); congestive heart failure (Disease Ontology:DOID:6000); pulmonary hypertension (Disease Ontology:DOID:6432); degenerative disc disease (Disease Ontology:DOID:90); diabetic neuropathy (Disease Ontology:DOID:9743)",
        "pathway": " (hsa:1907);  (R-HSA-375276);  (R-HSA-416476)",
        "pathway_count": 3,
        "publication_count": 126,
        "publication_id_list": "10.1038/emboj.2013.79;10079109;10100623;10191087;10381885;10421367;10421368;10438732;10461880;10498338;10499587;10567430;10604470;10727532;10854085;10861009;10899166;11015615;11322507;11385580;11457843;11562423;11683476;11742120;11753430;11773063;12120503;12427552;12540846;12719537;1280419;12956774;1314587;1317848;1325670;1337145;1346068;14463577;14550283;14573733;15139756;15539556;1567413;15947423;15951850;16182515;16268778;16339447;1655761;16754659;16923326;1701397;1710450;1710578;1719979;1722333;1725387;18127230;1840558;18434541;1847994;18515384;18577758;18936096;1905813;23446738;23584533;23690594;24647318;24906252;2649896;27496565;2841328;3086311;3202875;3366244;34360981;3525564;35679618;3856870;6274691;6281660;6373251;6589611;7057924;7524088;7590751;7592910;7592911;7624359;7797512;7905839;7937899;8035319;8062389;8063797;8185599;8201839;8248172;8294032;8373420;8381365;8383682;8395824;8440682;8463333;8503909;8615752;8664309;8666380;8702752;873923;8823230;9171878;9284755;9305846;9521323;9530155;9593744;9607765;9685625;9722565;9770463;9792798;9832121;9851594",
        "class_list": "",
        "function": "EDN2 expression in left internal mammary arteries depends on tissue harvesting technique., [RefSeq, PubMed]; Endothelins are endothelium-derived vasoconstrictor peptides., [UniProtKB]; Reduced Endothelin-2 and Hypoxic Signaling Pathways in Granulosa-Lutein Cells of PCOS Women. Publication Status: Online-Only, [RefSeq, PubMed]; The loss of endothelin-2 exhibits an anticancer effect in A549 human lung adenocarcinoma cell line., [RefSeq, PubMed]; This gene encodes a member of the endothelin protein family of secretory vasoconstrictive peptides. The preproprotein is processed to a short mature form which functions as a ligand for the endothelin receptors that initiate intracellular signaling events. This gene product is involved in a wide range of biological processes, such as hypertension and ovulation. Altered expression of this gene is implicated in tumorigenesis. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2014]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 5,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 5,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 5,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 34,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5T1R3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005179 hormone activity;GO:0031708 endothelin B receptor binding",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space",
        "go_biological_process": "GO:0086100 endothelin receptor signaling pathway;GO:0001525 angiogenesis;GO:0007166 cell surface receptor signaling pathway;GO:0008284 positive regulation of cell population proliferation;GO:0045987 positive regulation of smooth muscle contraction",
        "synthesized_glycan_count": 0,
        "hit_score": 13.3,
        "record_id": "P20800-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P29322-1",
        "uniprot_id": [
            {
                "id": "EPHA8_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P29322",
                "type": "external"
            }
        ],
        "mass": 111003.0,
        "length": 1005,
        "protein_name": "Ephrin type-A receptor 8",
        "gene_name": "EPHA8",
        "organism": "Human",
        "refseq_name": "ephrin type-A receptor 8 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001006944",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001006944",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPHA8; EEK; HEK3; KIAA1459",
        "gene_names_refseq": "EEK; EK3; EPHA8; HEK3",
        "protein_names_uniprotkb": "Ephrin type-A receptor 8; 2.7.10.1; EK3; EPH- and ELK-related kinase; EPH-like kinase 3; Tyrosine-protein kinase receptor EEK; hEK3",
        "protein_names_refseq": "EPH- and ELK-related kinase; EPH- and ELK-related tyrosine kinase; EPH-like kinase 3; ephrin type-A receptor 8 isoform 2 precursor; ephrin type-A receptor 8; hydroxyaryl-protein kinase; protein-tyrosine kinase; tyrosine-protein kinase receptor EEK; tyrosylprotein kinase",
        "tax_id": 9606,
        "disease": "Carney complex (Disease Ontology:DOID:0050471); primary pigmented nodular adrenocortical disease (Disease Ontology:DOID:0060280); primary pigmented nodular adrenocortical disease 1 (Disease Ontology:DOID:0070546); acrodysostosis (Disease Ontology:DOID:14669); follicular thyroid carcinoma (Disease Ontology:DOID:3962)",
        "pathway": " (hsa:2046);  (R-HSA-2682334);  (R-HSA-3928663);  (R-HSA-3928665)",
        "pathway_count": 4,
        "publication_count": 39,
        "publication_id_list": "10498895;10769020;10848605;11179879;11416136;11448999;11780069;12084815;12495863;12973357;15351694;15848799;15848800;1648701;16511561;17322526;17344846;17428795;17875921;17928214;18713744;19525919;20496116;26989075;27582484;28832583;29242379;30300334;31026069;31092671;32387766;32983136;33968037;34278497;35051231;36010968;37217939;38253038;9499402",
        "class_list": "",
        "function": "EphA8 inhibits cell apoptosis via AKT signaling and is associated with poor prognosis in breast cancer., [RefSeq, PubMed]; EphA8 knockdown also decreased expression of the protease ADAM10, [RefSeq, PubMed]; Gene-based analysis identified EPHA6 as the gene most significantly associated with paclitaxel-induced neuropathy...This first study sequencing EPHA genes revealed that low-frequency variants in EPHA6, EPHA5, and EPHA8 contribute to the susceptibility to paclitaxel-induced neuropathy, [RefSeq, PubMed]; High EPHA8 expression is associated with epithelial ovarian cancer., [RefSeq, PubMed]; Q-PCR and IHC staining revealed that EphA8 was highly expressed in OTSCC tissues, especially in advanced stage OTSCC tissues. Kaplan-Meier curve showed that high EphA8 expression was significantly associated with poor prognosis. Publication Status: Online-Only, [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. The GPI-anchored ephrin-A EFNA2, EFNA3, and EFNA5 are able to activate EPHA8 through phosphorylation. With EFNA5 may regulate integrin-mediated cell adhesion and migration on fibronectin substrate but also neurite outgrowth. During development of the nervous system also plays a role in axon guidance. Downstream effectors of the EPHA8 signaling pathway include FYN which promotes cell adhesion upon activation by EPHA8 and the MAP kinases in the stimulation of neurite outgrowth (By similarity)., [UniProtKB]; This gene encodes a member of the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. The protein encoded by this gene functions as a receptor for ephrin A2, A3 and A5 and plays a role in short-range contact-mediated axonal guidance during development of the mammalian nervous system. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 3,
        "predicted_n_glycosites": 3,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 47,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 5,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6IN80;Q8IUX6;Q9NUA9;Q9P269",
        "ec_number_list": [
            {
                "id": "3.4.24.81",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity;GO:0005004 GPI-linked ephrin receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0031901 early endosome membrane;GO:0043005 neuron projection",
        "go_biological_process": "GO:0033628 regulation of cell adhesion mediated by integrin;GO:0007155 cell adhesion;GO:0016322 neuron remodeling;GO:0030155 regulation of cell adhesion;GO:0031175 neuron projection development",
        "synthesized_glycan_count": 0,
        "hit_score": 4.2,
        "record_id": "P29322-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000010001.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P54753-1",
        "uniprot_id": [
            {
                "id": "EPHB3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P54753",
                "type": "external"
            }
        ],
        "mass": 110330.0,
        "length": 998,
        "protein_name": "Ephrin type-B receptor 3",
        "gene_name": "EPHB3",
        "organism": "Human",
        "refseq_name": "ephrin type-B receptor 3 precursor",
        "refseq_ac": [
            {
                "id": "NP_004434",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004434",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPHB3; ETK2; HEK2; TYRO6",
        "gene_names_refseq": "EK2; EPHB3; ETK2; HEK2; TYRO6",
        "protein_names_uniprotkb": "Ephrin type-B receptor 3; 2.7.10.1; EK2; EPH-like kinase 2; EPH-like tyrosine kinase 2; Embryonic kinase 2; Tyrosine-protein kinase TYRO6; hEK2",
        "protein_names_refseq": "EPH-like tyrosine kinase 2; embryonic kinase 2; ephrin type-B receptor 3 precursor; ephrin type-B receptor 3; human embryo kinase 2; tyrosine-protein kinase TYRO6",
        "tax_id": 9606,
        "disease": "malaria (Disease Ontology:DOID:12365); granulosa cell tumor (Disease Ontology:DOID:2999)",
        "pathway": " (hsa:2049);  (R-HSA-2682334);  (R-HSA-3928662);  (R-HSA-3928664);  (R-HSA-3928665)",
        "pathway_count": 5,
        "publication_count": 76,
        "publication_id_list": "10047984;10219243;10848605;10995436;11058585;11134074;11448999;11557983;11580899;11747816;11780069;11804587;11983165;12084815;12495863;12546821;12676796;12695502;12702722;12973357;14988728;15351694;15378065;15536074;15548136;15721239;15800193;15848800;15951569;16298995;16511561;17016520;17310244;17322526;17344846;17389395;17428795;17440041;17548511;17928214;18083107;18713744;19525919;19553453;19915143;20068231;20496116;2201922;23090970;24190977;25645385;29351928;29671580;29741879;30429286;31222486;32157095;32161166;32350084;32387766;32938616;33280498;33912179;34296545;35051231;35154160;35251023;35494241;36010968;37004604;37074911;38150866;7478585;8397371;9499402;9674711",
        "class_list": "",
        "function": "EphB3 protein is a potential ancillary diagnostic biomarker for thyroid cancers., [RefSeq, PubMed]; Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into two groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. This gene encodes a receptor for ephrin-B family members. [provided by RefSeq, Mar 2010]., [RefSeq]; Low Expression of EphB2, EphB3, and EphB4 in Bladder Cancer: Novel Potential Indicators of Muscular Invasion., [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Generally has an overlapping and redundant function with EPHB2. Like EPHB2, functions in axon guidance during development regulating for instance the neurons forming the corpus callosum and the anterior commissure, 2 major interhemispheric connections between the temporal lobes of the cerebral cortex. In addition to its role in axon guidance also plays an important redundant role with other ephrin-B receptors in development and maturation of dendritic spines and the formation of excitatory synapses. Controls other aspects of development through regulation of cell migration and positioning. This includes angiogenesis, palate development and thymic epithelium development for instance. Forward and reverse signaling through the EFNB2/EPHB3 complex also regulate migration and adhesion of cells that tubularize the urethra and septate the cloaca. Finally, plays an important role in intestinal epithelium differentiation segregating progenitor from differentiated cells in the crypt., [UniProtKB, PubMed]; Up-regulated lncRNA SNHG9 mediates the pathogenesis of dilated cardiomyopathy via miR-326/EPHB3 axis., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 25,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 13,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q7Z740",
        "ec_number_list": [
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.4.24.24",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.24",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "3.4.24.35",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.35",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "3.4.23.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.23.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0005005 transmembrane-ephrin receptor activity;GO:0005003 ephrin receptor activity;GO:0008046 axon guidance receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005829 cytosol;GO:0005886 plasma membrane;GO:0030425 dendrite",
        "go_biological_process": "GO:0050770 regulation of axonogenesis;GO:0001525 angiogenesis;GO:0016477 cell migration;GO:0048013 ephrin receptor signaling pathway;GO:0022407 regulation of cell-cell adhesion",
        "synthesized_glycan_count": 0,
        "hit_score": 9.3,
        "record_id": "P54753-1",
        "record_type": "protein",
        "filter_code": "0000000.1100111.010000.000000000001000000.1100000000001.100.00000",
        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "EP3B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P56851",
                "type": "external"
            }
        ],
        "mass": 17584.0,
        "length": 147,
        "protein_name": "Epididymal secretory protein E3-beta",
        "gene_name": "EDDM3B",
        "organism": "Human",
        "refseq_name": "epididymal secretory protein E3-beta precursor",
        "refseq_ac": [
            {
                "id": "NP_071755",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_071755",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EDDM3B; FAM12B; HE3B; PRO21187",
        "gene_names_refseq": "EDDM3B; EP3B; FAM12B; HE3-BETA; HE3B; RAM2",
        "protein_names_uniprotkb": "Epididymal secretory protein E3-beta; HE3-beta; Human epididymis-specific protein 3-beta",
        "protein_names_refseq": "epididymal secretory protein E3-beta precursor; epididymal secretory protein E3-beta; family with sequence similarity 12, member B (epididymal); human epididymis-specific 3 beta; human epididymis-specific protein 3-beta; ribonuclease A M2",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:64184)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "12975309;7514008",
        "class_list": "",
        "function": "Possible function in sperm maturation., [UniProtKB]; Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
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        "reported_c_glycosites_with_glycan": 0,
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        "reported_phosphosites": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A0PK89",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
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        "record_id": "P56851-1",
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        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14236-1",
        "uniprot_id": [
            {
                "id": "EPAG_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14236",
                "type": "external"
            }
        ],
        "mass": 17843.0,
        "length": 149,
        "protein_name": "Early lymphoid activation gene protein",
        "gene_name": "DIAPH2-AS1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "DIAPH2-AS1; EPAG",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Early lymphoid activation gene protein; DIAPH2 antisense RNA 1; DIAPH2 antisense gene protein 1",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 2,
        "publication_id_list": "30779550;8133036",
        "class_list": "",
        "function": "May function as an early signal that helps mediate the activation of T-cells., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_s_glycosites": 0,
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        "reported_glycation": 0,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "GO:0007165 signal transduction",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q14236-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
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    },
    {
        "uniprot_canonical_ac": "Q14264-1",
        "uniprot_id": [
            {
                "id": "ENR1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14264",
                "type": "external"
            }
        ],
        "mass": 67942.0,
        "length": 604,
        "protein_name": "Endogenous retrovirus group 3 member 1 Env polyprotein",
        "gene_name": "ERV3-1",
        "organism": "Human",
        "refseq_name": "endogenous retrovirus group 3 member 1 Env polyprotein precursor",
        "refseq_ac": [
            {
                "id": "NP_001007254",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001007254",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ERV3-1; ERV3",
        "gene_names_refseq": "ERV-R; ERV3-1; ERV3; ERVR; HERV-R; HERVR; envR",
        "protein_names_uniprotkb": "Endogenous retrovirus group 3 member 1 Env polyprotein; ERV-3 envelope protein; ERV-R envelope protein; ERV3 envelope protein; ERV3-1 envelope protein; Envelope polyprotein; HERV-R envelope protein; HERV-R_7q21.2 provirus ancestral Env polyprotein",
        "protein_names_refseq": "ERV-R envelope protein; ERV3-1 envelope protein; HERV-R envelope protein; HERV-R_7q21.2 provirus ancestral Env polyprotein; endogenous retroviral sequence 3; endogenous retrovirus group 3 member 1 Env polyprotein precursor; endogenous retrovirus group 3 member 1 Env polyprotein; endogenous retrovirus group 3, member 1",
        "tax_id": 9606,
        "disease": "hypertension (Disease Ontology:DOID:10763); thrombocytopenia (Disease Ontology:DOID:1588); lung squamous cell carcinoma (Disease Ontology:DOID:3907); lung adenocarcinoma (Disease Ontology:DOID:3910); colorectal cancer (Disease Ontology:DOID:9256)",
        "pathway": " (hsa:2086)",
        "pathway_count": 1,
        "publication_count": 25,
        "publication_id_list": "10.1101/2023.09.13.557529;10427470;10692254;12083821;12970426;14557543;15081124;17287340;25892735;28489076;29741879;29769354;31844290;32350084;32938616;33338509;33981976;35051231;35251023;35318648;36675007;37074911;3840930;7645262;9525678",
        "class_list": "",
        "function": "Endogenous Retrovirus RNA Expression Differences between Race, Stage and HPV Status Offer Improved Prognostication among Women with Cervical Cancer. Publication Status: Online-Only, [RefSeq, PubMed]; Expression of ERV3-1 in leukocytes of acute myelogenous leukemia patients., [RefSeq, PubMed]; Molecular evolution and comparison with other primates, [RefSeq, PubMed]; Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution. This endogenous envelope protein has lost its fusogenic properties. It can inhibit cell growth through decrease expression of cyclin B1 and increased expression of p21 in vitro., [UniProtKB, PubMed, PubMed, PubMed]; SU mediates receptor recognition., [UniProtKB]; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity)., [UniProtKB]; This gene contains sequence derived from endogenous retrovirus, and is therefore similar to multiple other loci in the genome. Transcripts at this locus encode a conserved protein with a predicted signal peptide and similarity to the Env polyprotein. This protein is overexpressed in colorectal and other cancers. [provided by RefSeq, Jan 2017]., [RefSeq]",
        "predicted_glycosites": 7,
        "predicted_n_glycosites": 7,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 2,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 2,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 2,
        "total_reported_o_glycosites": 0,
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        "total_n_glycosites": 2,
        "total_o_glycosites": 0,
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        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
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        "reported_snv": 44,
        "reported_interactions": 0,
        "missing_score": 8836,
        "biomarker_type": "",
        "glycan_count": 6,
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        "glyco_site_count": 9,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 3.4,
        "record_id": "Q14264-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14507-1",
        "uniprot_id": [
            {
                "id": "EP3A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14507",
                "type": "external"
            }
        ],
        "mass": 17646.0,
        "length": 147,
        "protein_name": "Epididymal secretory protein E3-alpha",
        "gene_name": "EDDM3A",
        "organism": "Human",
        "refseq_name": "epididymal secretory protein E3-alpha precursor",
        "refseq_ac": [
            {
                "id": "NP_006674",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006674",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EDDM3A; FAM12A; HE3A",
        "gene_names_refseq": "EDDM3A; EP3A; FAM12A; HE3-ALPHA; HE3ALPHA; HE3A; RAM1",
        "protein_names_uniprotkb": "Epididymal secretory protein E3-alpha; HE3-alpha; Human epididymis-specific protein 3-alpha",
        "protein_names_refseq": "epididymal secretory protein E3-alpha precursor; epididymal secretory protein E3-alpha; epididymis secretory sperm binding protein; family with sequence similarity 12, member A; human epididymis-specific 3 alpha; human epididymis-specific protein 3-alpha; ribonuclease A M1",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:10876)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "23481700;7514008",
        "class_list": "",
        "function": "Possible function in sperm maturation., [UniProtKB]; Testicular sperm are morphologically differentiated but are not progressively motile nor able to fertilize an egg. Post-testicular maturation requires exposure of spermatozoa to the microenvironment of the epididymal lumen. Spermatozoa undergo extensive changes in the epididymis, including enzymatic modifications, loss of pre-existing components and addition of new glycoproteins from epididymal secretions. These modifying proteins and enzymes are synthesized by epithelial cells lining the epididymal duct and secreted apically into the lumen, where they come into contact with, and may be absorbed onto, the sperm membranes. The proteins encoded by the genes in this cluster are synthesized and secreted by epididymal epithelial cells. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "mined_s_glycosites": 0,
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        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_snv": 3,
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        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q4KN33",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005615 extracellular space",
        "go_biological_process": "GO:0007321 sperm displacement",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "Q14507-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15375-1",
        "uniprot_id": [
            {
                "id": "EPHA7_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15375",
                "type": "external"
            }
        ],
        "mass": 112097.0,
        "length": 998,
        "protein_name": "Ephrin type-A receptor 7",
        "gene_name": "EPHA7",
        "organism": "Human",
        "refseq_name": "ephrin type-A receptor 7 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001275558",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001275558",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EPHA7; EHK3; HEK11",
        "gene_names_refseq": "EHK-3; EHK3; EK11; EPHA7; HEK11",
        "protein_names_uniprotkb": "Ephrin type-A receptor 7; 2.7.10.1; EHK-3; EK11; EPH homology kinase 3; EPH-like kinase 11; hEK11",
        "protein_names_refseq": "EPH homology kinase 3; EPH-like kinase 11; Eph homology kinase-3; ephrin type-A receptor 7 isoform 2 precursor; ephrin type-A receptor 7; receptor protein-tyrosine kinase HEK11; tyrosine-protein kinase receptor EHK-3",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:2045);  (R-HSA-2682334);  (R-HSA-3928663);  (R-HSA-3928665)",
        "pathway_count": 4,
        "publication_count": 44,
        "publication_id_list": "10.1101/2023.09.13.557529;10769020;10848605;11179879;11237011;11448999;11780069;12084815;12495863;12973357;15351694;15848799;15848800;16511561;16959974;17322526;17344846;17389395;17428795;17726105;17928214;18713744;19525919;20126984;20496116;24190977;27726376;28228285;28832583;29022918;29242379;29351928;29393594;29557506;30833945;31844290;34171305;34186436;35051231;35494241;35681118;37738252;7898931;9499402",
        "class_list": "",
        "function": "Crystal structure of clinically reported mutations Gly656Arg, Gly656Glu and Asp751His identified in the kinase domain of EphA7., [RefSeq, PubMed]; Receptor tyrosine kinase which binds promiscuously GPI-anchored ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Among GPI-anchored ephrin-A ligands, EFNA5 is a cognate/functional ligand for EPHA7 and their interaction regulates brain development modulating cell-cell adhesion and repulsion. Has a repellent activity on axons and is for instance involved in the guidance of corticothalamic axons and in the proper topographic mapping of retinal axons to the colliculus. May also regulate brain development through a caspase(CASP3)-dependent proapoptotic activity. Forward signaling may result in activation of components of the ERK signaling pathway including MAP2K1, MAP2K2, MAPK1 and MAPK3 which are phosphorylated upon activation of EPHA7., [UniProtKB, PubMed]; STAT3-EphA7 axis contributes to the progression of esophageal squamous cell carcinoma., [RefSeq, PubMed]; The identification and validation of EphA7 hypermethylation, a novel biomarker, in cervical cancer. Publication Status: Online-Only, [RefSeq, PubMed]; This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Increased expression of this gene is associated with multiple forms of carcinoma. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]., [RefSeq]",
        "predicted_glycosites": 2,
        "predicted_n_glycosites": 2,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
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        "reported_n_glycosites": 1,
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        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 2,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 79,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 0,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A0AUX7;B2R8W1;B7ZLJ9;B7ZLK0;Q59G40;Q5VTU0;Q8N368;Q9H124",
        "ec_number_list": [
            {
                "id": "3.4.24.81",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.4.24.81",
                "type": "external"
            },
            {
                "id": "2.7.12.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.2",
                "type": "external"
            },
            {
                "id": "2.7.10.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.1",
                "type": "external"
            },
            {
                "id": "2.7.10.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.2",
                "type": "external"
            },
            {
                "id": "2.7.11.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.1",
                "type": "external"
            },
            {
                "id": "2.7.12.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.12.1",
                "type": "external"
            },
            {
                "id": "2.7.1.40",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.40",
                "type": "external"
            },
            {
                "id": "2.7.1.32",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.32",
                "type": "external"
            },
            {
                "id": "2.7.1.82",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.1.82",
                "type": "external"
            },
            {
                "id": "2.7.10.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.10.4",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "2.7.11.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.13",
                "type": "external"
            },
            {
                "id": "2.7.11.23",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.11.23",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0004713 protein tyrosine kinase activity;GO:0005524 ATP binding;GO:0019838 growth factor binding;GO:0046875 ephrin receptor binding;GO:0045499 chemorepellent activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005886 plasma membrane;GO:0030425 dendrite;GO:0031594 neuromuscular junction;GO:0043025 neuronal cell body",
        "go_biological_process": "GO:0048755 branching morphogenesis of a nerve;GO:0048013 ephrin receptor signaling pathway;GO:0006915 apoptotic process;GO:0022407 regulation of cell-cell adhesion;GO:0007420 brain development",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q15375-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.010000.000000000001000000.1100000010001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q58FF3-1",
        "uniprot_id": [
            {
                "id": "ENPLL_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q58FF3",
                "type": "external"
            }
        ],
        "mass": 45859.0,
        "length": 399,
        "protein_name": "Putative endoplasmin-like protein",
        "gene_name": "HSP90B2P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "HSP90B2P; GRP94B; GRP94P1; TRAP1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative endoplasmin-like protein; Putative heat shock protein 90 kDa beta member 2",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "male infertility due to globozoospermia (Disease Ontology:DOID:0112312)",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 34,
        "publication_id_list": "16269234;24190977;25548167;25645385;25772364;25880248;26375851;26992070;27600516;28514659;28832583;28834231;28855257;29242379;29508533;29557506;29632711;29786170;30524438;31154438;31844290;31848261;31998317;32161166;32357974;32387766;32502341;33298915;33537174;33968037;33981976;34509645;35051231;36010968",
        "class_list": "",
        "function": "Putative molecular chaperone., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005524 ATP binding;GO:0019901 protein kinase binding;GO:0051082 unfolded protein binding;GO:0016887 ATP hydrolysis activity;GO:0140662 ATP-dependent protein folding chaperone",
        "go_cellular_component": "GO:0005743 mitochondrial inner membrane",
        "go_biological_process": "GO:0006457 protein folding",
        "synthesized_glycan_count": 0,
        "hit_score": 3.6,
        "record_id": "Q58FF3-1",
        "record_type": "protein",
        "filter_code": "0000000.0000110.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q5JPI9-2",
        "uniprot_id": [
            {
                "id": "EFMT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q5JPI9",
                "type": "external"
            }
        ],
        "mass": 25904.0,
        "length": 236,
        "protein_name": "EEF1A lysine methyltransferase 2",
        "gene_name": "EEF1AKMT2",
        "organism": "Human",
        "refseq_name": "EEF1A lysine methyltransferase 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001291396",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001291396",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EEF1AKMT2; C10orf138; METTL10",
        "gene_names_refseq": "C10orf138; EEF1AKMT2; Efm4; METTL10",
        "protein_names_uniprotkb": "EEF1A lysine methyltransferase 2; 2.1.1.-; Methyltransferase-like protein 10; Protein-lysine N-methyltransferase METTL10",
        "protein_names_refseq": "EEF1A lysine methyltransferase 2 isoform 2; eukaryotic translation elongation factor 1 alpha lysine methyltransferase 2; methyltransferase like 10; methyltransferase-like protein 10; protein-lysine N-methyltransferase METTL10",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:399818);  (R-HSA-8876725)",
        "pathway_count": 2,
        "publication_count": 29,
        "publication_id_list": "16118227;16385451;18669648;20068231;23186163;23349634;25144183;25231979;25416781;25576301;25645385;25802875;26375851;26545399;27600516;28228285;28832583;28834231;29242379;29632046;29786170;29789417;30315122;30779550;30833945;31154438;32161166;35494241;38199565",
        "class_list": "",
        "function": "Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'., [UniProtKB, HAMAP, PubMed, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "total_reported_c_glycosites": 0,
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        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 4,
        "reported_mutagensis": 3,
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        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A0A494BZY7;A8MPY7",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            },
            {
                "id": "2.1.1.359",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.359",
                "type": "external"
            },
            {
                "id": "2.1.1.372",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.372",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0008168 methyltransferase activity;GO:0016279 protein-lysine N-methyltransferase activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0005829 cytosol",
        "go_biological_process": "GO:0006479 protein methylation;GO:0018022 peptidyl-lysine methylation",
        "synthesized_glycan_count": 0,
        "hit_score": 3.0,
        "record_id": "Q5JPI9-2",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IUX8-1",
        "uniprot_id": [
            {
                "id": "EGFL6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IUX8",
                "type": "external"
            }
        ],
        "mass": 61317.0,
        "length": 553,
        "protein_name": "Epidermal growth factor-like protein 6",
        "gene_name": "EGFL6",
        "organism": "Human",
        "refseq_name": "epidermal growth factor-like protein 6 isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001161362",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001161362",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EGFL6; MAEG; PP648; PRO320",
        "gene_names_refseq": "EGFL6; MAEG; W80",
        "protein_names_uniprotkb": "Epidermal growth factor-like protein 6; EGF-like protein 6; MAM and EGF domains-containing gene protein",
        "protein_names_refseq": "EGF repeat-containing protein 6; EGF-like protein 6; MAM and EGF domain containing; MAM and EGF domains-containing gene protein; epidermal growth factor-like protein 6 isoform 2 precursor; epidermal growth factor-like protein 6",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:25975)",
        "pathway_count": 1,
        "publication_count": 19,
        "publication_id_list": "10610727;10777661;12975309;15498874;16959974;18038328;20574786;22984286;23285163;29242379;29557506;32157095;34411563;35051231;35220882;35457174;38368816;39187367;39312740",
        "class_list": "",
        "function": "Cytoplasmic Expression of the EGFL6 Protein Is an Independent Prognostic Factor for Shortened Patient Survival in Human Hepatocellular Carcinoma., [RefSeq, PubMed]; EGFL6 promotes endometrial cancer cell migration and proliferation., [RefSeq, PubMed]; EGFL6 was overexpressed in benign meningioma tissues and serum., [RefSeq, PubMed]; Egfl6 promotes ovarian cancer progression by enhancing the immunosuppressive functions of tumor-associated myeloid cells. Publication Status: Online-Only, [RefSeq, PubMed]; Epidermal growth factor-like domain protein 6 recombinant protein facilitates osteogenic differentiation in adipose stem cells via bone morphogenetic protein 2/recombinant mothers against decapentaplegic homolog 4 signaling pathway., [RefSeq, PubMed]; May bind integrin alpha-8/beta-1 and play a role in hair follicle morphogenesis. Promotes matrix assembly (By similarity)., [UniProtKB]; Results indicate that human EGFL6 is a paracrine/autocrine growth factor of adipose tissue up-regulated in obesity and potentially involved in the process of adipose tissue expansion and the development of obesity, [RefSeq, PubMed]; There is an absence of GNAS and EGFL6 mutations in common human cancers., [RefSeq, PubMed]; This gene encodes a member of the epidermal growth factor (EGF) repeat superfamily. Members of this superfamily are characterized by the presence of EGF-like repeats and are often involved in the regulation of cell cycle, proliferation, and developmental processes. The gene product contains a signal peptide, suggesting that it is secreted; an EGF repeat region consisting of 4 complete EGF-like repeats and 1 partial EGF-like repeat, 3 of which have a calcium-binding consensus sequence; an arg-gly-asp integrin association motif; and a MAM domain, which is believed to have an adhesive function. This gene is expressed early during development, and its expression has been detected in lung and meningioma tumors. [provided by RefSeq, Jul 2008]., [RefSeq]; Transcriptome Analyses of Adipose Tissue Samples Identify EGFL6 as a Candidate Gene Involved in Obesity-Related Adipose Tissue Dysfunction in Children. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_n_glycosites": 0,
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        "mined_c_glycosites": 0,
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        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 3,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 3,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 3,
        "total_c_glycosites": 0,
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        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 4,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RCB1;Q6UXJ1;Q8NBV0;Q8WYG3;Q9NY67;Q9NZL7;Q9UFK6",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005178 integrin binding;GO:0005509 calcium ion binding",
        "go_cellular_component": "GO:0005615 extracellular space;GO:0016020 membrane;GO:0005604 basement membrane",
        "go_biological_process": "GO:0007155 cell adhesion;GO:0030154 cell differentiation",
        "synthesized_glycan_count": 0,
        "hit_score": 2.4,
        "record_id": "Q8IUX8-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000010000.001.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8IYF1-1",
        "uniprot_id": [
            {
                "id": "ELOA2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8IYF1",
                "type": "external"
            }
        ],
        "mass": 83921.0,
        "length": 753,
        "protein_name": "Elongin-A2",
        "gene_name": "ELOA2",
        "organism": "Human",
        "refseq_name": "elongin-A2",
        "refseq_ac": [
            {
                "id": "NP_057511",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_057511",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ELOA2; TCEB3B; TCEB3L",
        "gene_names_refseq": "ELOA2; HsT832; TCEB3B; TCEB3L",
        "protein_names_uniprotkb": "Elongin-A2; EloA2; RNA polymerase II transcription factor SIII subunit A2; Transcription elongation factor B polypeptide 3B",
        "protein_names_refseq": "RNA polymerase II transcription factor SIII subunit A2; elongin-A2; transcription elongation factor (SIII) elongin A2 elongin A2; transcription elongation factor B polypeptide 3B; transcription elongation factor B subunit 3B",
        "tax_id": 9606,
        "disease": "candidiasis (Disease Ontology:DOID:1508)",
        "pathway": " (hsa:51224);  (R-HSA-112382);  (R-HSA-167152);  (R-HSA-167200);  (R-HSA-167238);  (R-HSA-167243);  (R-HSA-167246);  (R-HSA-167287);  (R-HSA-167290);  (R-HSA-674695);  (R-HSA-6796648);  (R-HSA-75955)",
        "pathway_count": 12,
        "publication_count": 43,
        "publication_id_list": "10.1074/mcp.M114.046862;10199401;10692460;10757782;10866664;10984493;11313498;11313499;11350971;11859374;11884399;11971958;11988847;12676794;14701750;15489290;15781865;16959974;17234882;1939271;19952111;20159561;22012619;22988298;23538671;2449431;24554720;24662513;25429106;25561469;25712099;25813380;26659056;35051231;37217939;7660122;7660129;7660130;7853496;8370526;9063748;9450929;9489704",
        "class_list": "",
        "function": "SIII, also known as elongin, is a general transcription elongation factor that increases the RNA polymerase II transcription elongation past template-encoded arresting sites. Subunit A2 is transcriptionally active but its transcription activity is not enhanced by binding to the dimeric complex of the SIII regulatory subunits B and C (elongin BC complex)., [UniProtKB, PubMed]; This gene encodes the transcriptionally active subunit of the SIII (or elongin) transcription elongation factor complex, which also includes two regulatory subunits, elongins B and C. This complex acts to increase the rate of RNA chain elongation by RNA polymerase II by suppressing transient pausing of the polymerase at many sites along the DNA template. Whereas a related protein with similar function, elongin A, is ubiquitously expressed, the encoded protein is specifically expressed in the testis, suggesting it may have a role in spermatogenesis. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 4,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 4,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 4,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 2,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 44,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 2,
        "disease_count": 1,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q9P2V9",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005654 nucleoplasm;GO:0070449 elongin complex",
        "go_biological_process": "GO:0006366 transcription by RNA polymerase II;GO:0006368 transcription elongation by RNA polymerase II;GO:0032784 regulation of DNA-templated transcription elongation",
        "synthesized_glycan_count": 0,
        "hit_score": 5.0,
        "record_id": "Q8IYF1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q8N140-1",
        "uniprot_id": [
            {
                "id": "EID3_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q8N140",
                "type": "external"
            }
        ],
        "mass": 38168.0,
        "length": 333,
        "protein_name": "EP300-interacting inhibitor of differentiation 3",
        "gene_name": "EID3",
        "organism": "Human",
        "refseq_name": "EP300-interacting inhibitor of differentiation 3",
        "refseq_ac": [
            {
                "id": "NP_001008395",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001008395",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EID3",
        "gene_names_refseq": "EID3; NS4EB; NSE4B; NSMCE4B",
        "protein_names_uniprotkb": "EP300-interacting inhibitor of differentiation 3; E1A-like inhibitor of differentiation 3; EID-1-like inhibitor of differentiation 3; EID-3; NS4EB; Non-SMC element 4 homolog B; Non-structural maintenance of chromosomes element 4 homolog B",
        "protein_names_refseq": "E1A-like inhibitor of differentiation 3; EID-1-like inhibitor of differentiation 3; EID-3; EP300-interacting inhibitor of differentiation 3; NSE4 homolog B; non-SMC element 4 homolog B; non-structural maintenance of chromosomes element 4 homolog B; testis tissue sperm-binding protein Li 96mP",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:493861);  (R-HSA-3108214)",
        "pathway_count": 2,
        "publication_count": 63,
        "publication_id_list": "10574707;11792325;11889051;15175327;15355988;15608651;15823533;15829507;15940266;15959518;15987788;16030353;16478998;16608850;16626738;16688858;16810316;17693435;18086888;18625722;18691969;18708356;19287951;19596686;19622798;19706679;19779455;19956565;20016594;20016603;20068231;20190268;20705237;21098080;21147198;21284855;21364888;21550342;22508508;22635276;22661230;22751501;23750026;23871147;24027577;24782567;25114211;25218447;27846572;29393594;29493099;30114644;30379171;30833945;31844290;34171305;35051231;36071872;38216090;9412458;9452416;9756909;9885291",
        "class_list": "",
        "function": "Acts as a repressor of nuclear receptor-dependent transcription possibly by interfering with CREBBP-dependent coactivation. May function as a coinhibitor of other CREBBP/EP300-dependent transcription factors., [UniProtKB, PubMed]; EID3 Promotes Cancer Stem Cell-Like Phenotypes in Osteosarcoma through the Activation of PI3K-AKT Signaling Pathway. Publication Status: Online-Only, [RefSeq, PubMed]; EID3 acts as an inhibitor of CBP/p300-dependent transcription in a tissue-specific manner. Publication Status: Online-Only, [RefSeq, PubMed]; EID3 inhibits the osteogenic differentiation of periodontal ligament stem cells and mediates the signal transduction of TAZ-EID3-AKT/MTOR/ERK., [RefSeq, PubMed]; Knockdown of EID3 by specific shRNA attenuated BMS-345541 -induced radiosensitization in MCF-7 cells., [RefSeq, PubMed]; Tissue-specific component of the SMC5-SMC6 complex, a complex involved in repair of DNA double-strand breaks by homologous recombination. The complex may promote sister chromatid homologous recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand breaks. The complex is required for telomere maintenance via recombination and mediates sumoylation of shelterin complex (telosome) components., [UniProtKB, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 5,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 5,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005654 nucleoplasm;GO:0005730 nucleolus;GO:0005737 cytoplasm;GO:0000781 chromosome, telomeric region",
        "go_biological_process": "GO:0032204 regulation of telomere maintenance;GO:0006281 DNA repair;GO:0006351 DNA-templated transcription;GO:0016925 protein sumoylation;GO:0000724 double-strand break repair via homologous recombination",
        "synthesized_glycan_count": 0,
        "hit_score": 6.6,
        "record_id": "Q8N140-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9BV81-1",
        "uniprot_id": [
            {
                "id": "EMC6_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9BV81",
                "type": "external"
            }
        ],
        "mass": 12017.0,
        "length": 110,
        "protein_name": "ER membrane protein complex subunit 6",
        "gene_name": "EMC6",
        "organism": "Human",
        "refseq_name": "ER membrane protein complex subunit 6",
        "refseq_ac": [
            {
                "id": "NP_001014764",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001014764",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "EMC6; TMEM93",
        "gene_names_refseq": "EMC6; RAB5IFL; TMEM93",
        "protein_names_uniprotkb": "ER membrane protein complex subunit 6; Transmembrane protein 93",
        "protein_names_refseq": "ER membrane protein complex subunit 6; transmembrane protein 93",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:83460)",
        "pathway_count": 1,
        "publication_count": 34,
        "publication_id_list": "22119785;23182941;23481700;24715725;25892735;26154972;26992070;27920218;28514659;28648145;28742203;28832583;29242231;29242379;29393594;29557506;29632046;29769354;29786170;29809151;30415835;31844290;32387766;32439656;32459176;32502341;33141586;33177505;33392160;33717175;35051231;35154160;36284347;38445807",
        "class_list": "",
        "function": "EMC6 regulates acinar apoptosis via APAF1 in acute and chronic pancreatitis. Publication Status: Online-Only, [RefSeq, PubMed]; Endoplasmic membrane protein complex subunit 6 (EMC6) interacted with both RAB5A and BECN1/Beclin 1 and colocalized with the omegasome marker ZFYVE1/DFCP1., [RefSeq, PubMed]; Inhibition of UBA52 induces autophagy via EMC6 to suppress hepatocellular carcinoma tumorigenesis and progression., [RefSeq, PubMed]; Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins (PubMed:29242231, PubMed:29809151, PubMed:30415835, PubMed:32439656, PubMed:32459176). Preferentially accommodates proteins with transmembrane domains that are weakly hydrophobic or contain destabilizing features such as charged and aromatic residues (PubMed:29242231, PubMed:29809151, PubMed:30415835). Involved in the cotranslational insertion of multi-pass membrane proteins in which stop-transfer membrane-anchor sequences become ER membrane spanning helices (PubMed:29809151, PubMed:30415835). It is also required for the post-translational insertion of tail-anchored/TA proteins in endoplasmic reticulum membranes (PubMed:29242231, PubMed:29809151). By mediating the proper cotranslational insertion of N-terminal transmembrane domains in an N-exo topology, with translocated N-terminus in the lumen of the ER, controls the topology of multi-pass membrane proteins like the G protein-coupled receptors (PubMed:30415835). By regulating the insertion of various proteins in membranes, it is indirectly involved in many cellular processes (Probable)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed]; The expression level of EMC-6 is significantly elevated in cervical cancer, without significant correlation with Beclin1 and Rab5a., [RefSeq, PubMed]; This is the first study to show that EMC6 induces cell death in gastric cancer cells. The molecular mechanism of how EMC6 functions as a tumor suppressor needs to be further explored., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0072546 EMC complex;GO:0016020 membrane;GO:0005789 endoplasmic reticulum membrane;GO:1903349 omegasome membrane",
        "go_biological_process": "GO:0000045 autophagosome assembly;GO:0071816 tail-anchored membrane protein insertion into ER membrane;GO:0045050 protein insertion into ER membrane by stop-transfer membrane-anchor sequence",
        "synthesized_glycan_count": 0,
        "hit_score": 3.5,
        "record_id": "Q9BV81-1",
        "record_type": "protein",
        "filter_code": "0000000.0100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9NX77-1",
        "uniprot_id": [
            {
                "id": "ENK13_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9NX77",
                "type": "external"
            }
        ],
        "mass": 55045.0,
        "length": 482,
        "protein_name": "Endogenous retrovirus group K member 13-1 Env polyprotein",
        "gene_name": "ERVK13-1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "ERVK13-1",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Endogenous retrovirus group K member 13-1 Env polyprotein; Envelope polyprotein; HERV-K_16p13.3 provirus ancestral Env polyprotein",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 3,
        "publication_id_list": "29557506;30779550;33091337",
        "class_list": "",
        "function": "Retroviral envelope proteins mediate receptor recognition and membrane fusion during early infection. Endogenous envelope proteins may have kept, lost or modified their original function during evolution (By similarity)., [UniProtKB]; SU mediates receptor recognition., [UniProtKB]; TM anchors the envelope heterodimer to the viral membrane through one transmembrane domain. The other hydrophobic domain, called fusion peptide, mediates fusion of the viral membrane with the target cell membrane (By similarity)., [UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A8K9G3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005198 structural molecule activity",
        "go_cellular_component": "GO:0005886 plasma membrane",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.4,
        "record_id": "Q9NX77-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q9Y5L3-1",
        "uniprot_id": [
            {
                "id": "ENTP2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q9Y5L3",
                "type": "external"
            }
        ],
        "mass": 53665.0,
        "length": 495,
        "protein_name": "Ectonucleoside triphosphate diphosphohydrolase 2",
        "gene_name": "ENTPD2",
        "organism": "Human",
        "refseq_name": "ectonucleoside triphosphate diphosphohydrolase 2 isoform 2",
        "refseq_ac": [
            {
                "id": "NP_001237",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001237",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "ENTPD2; CD39L1",
        "gene_names_refseq": "CD39L1; ENTPD2; NTPDase-2",
        "protein_names_uniprotkb": "Ectonucleoside triphosphate diphosphohydrolase 2; 3.6.1.5; CD39 antigen-like 1; E-NTPDase 2; Ecto-ATP diphosphohydrolase 2; Ecto-ATPDase 2; Ecto-ATPase 2; NTPDase 2",
        "protein_names_refseq": "CD39 antigen-like 1; E-NTPDase 2; NTPDase 2; ecto-ATP diphosphohydrolase 2; ecto-ATPDase 2; ecto-ATPase 2; ectonucleoside triphosphate diphosphohydrolase 2 isoform 2",
        "tax_id": 9606,
        "disease": "hypertension (Disease Ontology:DOID:10763); primary biliary cholangitis (Disease Ontology:DOID:12236); high grade glioma (Disease Ontology:DOID:3070); liver cirrhosis (Disease Ontology:DOID:5082)",
        "pathway": " (hsa:954);  (R-HSA-8850843)",
        "pathway_count": 2,
        "publication_count": 54,
        "publication_id_list": "10.1101/2023.09.13.557529;10400613;10470077;10510450;10681547;10866813;10948193;11041856;11041857;11278936;11927941;11929769;12694193;12888562;14529283;14675084;15122917;15130768;16101300;16338080;17095758;17489562;17502665;18404504;18404510;18656957;19640930;20682839;21074248;21586362;22169232;23241884;23481700;28472257;28832583;28894087;29242379;29273916;29508533;29741879;29786170;30429286;30833945;32350084;34171305;35051231;35251023;38253038;8955160;8995405;9271669;9364474;9556635;9675246",
        "class_list": "",
        "function": "Catalytically inactive., [UniProtKB, PubMed]; Catalyzes the hydrolysis of nucleoside triphosphates (NTPs) and diphosphates (NDPs), with a marked preference for triphosphonucleosides over diphosphonucleosides (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). The enzyme sequentially removes phosphate groups in two successive steps, converting NTPs to nucleoside monophosphates (NMPs) via NDP intermediates (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). This activity contributes to the regulation of extracellular nucleotides levels (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). ATP hydrolysis is characterized by fast ADP accumulation and delayed AMP formation, reflecting limited ADP hydrolase activity (By similarity). Hydrolyzes ADP and UDP only to a marginal extent, and does not hydrolyze AMP (PubMed:10510450, PubMed:12888562, PubMed:16101300, PubMed:18404504). All nucleoside 5'-diphosphates are hydrolyzed at rates lower than those of their corresponding triphosphates (By similarity)., [UniProtKB, PubMed, UniProtKB, PubMed, PubMed, PubMed]; Hypoxia upregulates ENTPD2 through HIF-1alpha in hepatocellular carcinoma and subsequently leading to the accumulation of extracellular 5'-AMP, which maintains myeloid-derived suppressor cells undifferentiated. Publication Status: Online-Only, [RefSeq, PubMed]; In oviducts, remarkably, ectonucleoside triphosphate diphosphohydrolase 2 (NTPDase2), with the ability to hydrolyze ATP to AMP, are expressed in ciliated epithelial cells but with different subcellular localization., [RefSeq, PubMed]; NTPDase2 and -3 are ecto-enzymes expressed in the enteric nervous system. Both enzymes confer protection against gut inflammation in experimental colitis and exhibit alterations in Crohn's disease. These observations suggest that purinergic signalling modulated by E-NTPDases governs neuro-immune interactions that are relevant in Crohn's disease., [RefSeq, PubMed]; The lack of ecto-nucleotidase activity exhibited by NTPDase2 beta and -2 gamma and the C399S mutant, as well as the large reduction of activity in the N443D mutant are due to alterations in the folding/maturation of these proteins, [RefSeq, PubMed]; The protein encoded by this gene is the type 2 enzyme of the ecto-nucleoside triphosphate diphosphohydrolase family (E-NTPDase). E-NTPDases are a family of ecto-nucleosidases that hydrolyze 5'-triphosphates. This ecto-ATPase is an integral membrane protein. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Jul 2008]., [RefSeq]; The role of cysteine 26 in the catalytic activity of NTPDase-2 and as the target of p-chloromercuriphenylsulfonate (pCMPS), a sulfhydryl reagent and NTPDase-2 inhibitor, is reported., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 2,
        "mined_n_glycosites": 2,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 5,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 5,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 2,
        "reported_glycation": 0,
        "reported_snv": 27,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 50,
        "disease_count": 4,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "O15464;Q5SPY6;Q5SPY7",
        "ec_number_list": [
            {
                "id": "3.6.5.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.-",
                "type": "external"
            },
            {
                "id": "5.6.2.4",
                "url": "https://www.rhea-db.org/rhea/?query=ec:5.6.2.4",
                "type": "external"
            },
            {
                "id": "3.6.5.2",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.2",
                "type": "external"
            },
            {
                "id": "3.6.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.-",
                "type": "external"
            },
            {
                "id": "3.6.4.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.-",
                "type": "external"
            },
            {
                "id": "3.6.4.13",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.13",
                "type": "external"
            },
            {
                "id": "3.6.5.3",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.3",
                "type": "external"
            },
            {
                "id": "3.6.5.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.5.5",
                "type": "external"
            },
            {
                "id": "3.6.4.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.6",
                "type": "external"
            },
            {
                "id": "3.6.1.6",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.6",
                "type": "external"
            },
            {
                "id": "3.6.1.5",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.1.5",
                "type": "external"
            },
            {
                "id": "2.7.7.7",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.7",
                "type": "external"
            },
            {
                "id": "2.7.7.49",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.7.7.49",
                "type": "external"
            },
            {
                "id": "3.6.4.10",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.6.4.10",
                "type": "external"
            },
            {
                "id": "3.1.3.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.1.3.1",
                "type": "external"
            },
            {
                "id": "3.9.1.1",
                "url": "https://www.rhea-db.org/rhea/?query=ec:3.9.1.1",
                "type": "external"
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                "id": "3.1.-.-",
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        "protein_names_refseq": "RNA 2'-O-methyltransferase FBLL1; fibrillarin like 1; protein-glutamine methyltransferase; rRNA/tRNA 2'-O-methyltransferase fibrillarin-like protein 1",
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        "secondary_ac_list": "R4GMW7",
        "ec_number_list": [
            {
                "id": "2.1.1.-",
                "url": "https://www.rhea-db.org/rhea/?query=ec:2.1.1.-",
                "type": "external"
            }
        ],
        "go_molecular_function": "GO:0003723 RNA binding;GO:0008649 rRNA methyltransferase activity;GO:1990259 histone H2AQ104 methyltransferase activity;GO:0062105 RNA 2'-O-methyltransferase activity",
        "go_cellular_component": "GO:0005730 nucleolus;GO:0001650 fibrillar center;GO:0015030 Cajal body;GO:0031428 box C/D methylation guide snoRNP complex;GO:0032040 small-subunit processome",
        "go_biological_process": "GO:0031167 rRNA methylation;GO:0016556 mRNA modification;GO:0048255 mRNA stabilization;GO:0030182 neuron differentiation;GO:0000494 box C/D sno(s)RNA 3'-end processing",
        "synthesized_glycan_count": 0,
        "hit_score": 1.3,
        "record_id": "A6NHQ2-1",
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        "filter_code": "0000000.1100101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
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        "uniprot_id": [
            {
                "id": "FA47D_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NHR8",
                "type": "external"
            }
        ],
        "mass": 46757.0,
        "length": 397,
        "protein_name": "Putative protein FAM47D",
        "gene_name": "FAM47DP",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "FAM47DP",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative protein FAM47D",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 7,
        "publication_id_list": "25576301;29557506;30379171;31844290;32387766;35051231;36215666",
        "class_list": "",
        "function": "",
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        "go_cellular_component": "",
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        "record_id": "A6NHR8-1",
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        "filter_code": "0000000.0000100.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "A6NMN3-1",
        "uniprot_id": [
            {
                "id": "F170B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/A6NMN3",
                "type": "external"
            }
        ],
        "mass": 32092.0,
        "length": 283,
        "protein_name": "Protein FAM170B",
        "gene_name": "FAM170B",
        "organism": "Human",
        "refseq_name": "protein FAM170B",
        "refseq_ac": [
            {
                "id": "NP_001157956",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001157956",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM170B; C10orf73",
        "gene_names_refseq": "C10orf73; FAM170B",
        "protein_names_uniprotkb": "Protein FAM170B; Acrosome-related protein",
        "protein_names_refseq": "acrosome-related protein; protein FAM170B; putative protein FAM170B",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:170370)",
        "pathway_count": 1,
        "publication_count": 2,
        "publication_id_list": "26179146;32588889",
        "class_list": "",
        "function": "Knockout of family with sequence similarity 170 member A (Fam170a) causes male subfertility, while Fam170b is dispensable in micedagger., [RefSeq, PubMed]; Plays a role in fertilization through the acrosome reaction., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
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        "missing_score": 10000,
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        "secondary_ac_list": "Q86WY6;Q8N6K8",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0001669 acrosomal vesicle;GO:0002081 outer acrosomal membrane",
        "go_biological_process": "GO:2000344 positive regulation of acrosome reaction;GO:0009566 fertilization;GO:0080154 regulation of fertilization",
        "synthesized_glycan_count": 0,
        "hit_score": 0.3,
        "record_id": "A6NMN3-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P0C2W1-1",
        "uniprot_id": [
            {
                "id": "FBSP1_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P0C2W1",
                "type": "external"
            }
        ],
        "mass": 30633.0,
        "length": 286,
        "protein_name": "F-box/SPRY domain-containing protein 1",
        "gene_name": "FBXO45",
        "organism": "Human",
        "refseq_name": "F-box/SPRY domain-containing protein 1",
        "refseq_ac": [
            {
                "id": "NP_001099043",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001099043",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FBXO45; FBX45",
        "gene_names_refseq": "FBXO45; Fbx45",
        "protein_names_uniprotkb": "F-box/SPRY domain-containing protein 1; F-box only protein 45; hFbxo45",
        "protein_names_refseq": "F-box only protein 45; F-box/SPRY domain-containing protein 1; hFbxo45",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:200933)",
        "pathway_count": 1,
        "publication_count": 28,
        "publication_id_list": "11237011;15520277;16012741;19581926;24878430;24992930;25892735;26068074;28904123;29769354;29786170;29997255;30379171;31222486;31285543;31844290;32387766;32938616;33912179;33968037;34171305;34357683;35051231;35279684;35838331;36379255;37814093;39016138",
        "class_list": "",
        "function": "Component of E3 ubiquitin ligase complex consisting of FBXO45, MYCBP2 and SKP1 (PubMed:29997255). Functions in substrate recognition but also plays an important role in assembly of the complex (PubMed:29997255). Required for normal neuromuscular synaptogenesis, axon pathfinding and neuronal migration (By similarity). Regulates neuron migration during brain development through interaction with N-cadherin/CDH2 after secretion via a non-classical mechanism (By similarity). Plays a role in the regulation of neurotransmission at mature neurons (By similarity). May control synaptic activity by controlling UNC13A via ubiquitin dependent pathway (By similarity). Specifically recognizes TP73, promoting its ubiquitination and degradation. Polyubiquitinates NMNAT2, an adenylyltransferase that acts as an axon maintenance factor, and regulates its stability and degradation by the proteasome (PubMed:29997255). Also acts by ubiquitinating FBXW7 during prolonged mitotic arrest and promotes FBXW7 proteasomal degradation (PubMed:31285543). Induces subsequently an increase in mitotic slippage and prevents mitotic cell death (PubMed:31285543). In response to influenza infection, mediates interferon-lambda receptor IFNLR1 polyubiquitination and degradation through the ubiquitin-proteasome system by docking with its intracellular receptor domain (PubMed:36379255)., [UniProtKB, PubMed, UniProtKB, PubMed, UniProtKB, PubMed, PubMed]; Correlation of FBXO45 Expression Levels with Cancer Severity by ZEB1 Ubiquitin in Non-Small-Cell Lung Cancer., [RefSeq, PubMed]; FBXO45 gene consisting of 3 exons, and the vicinity of the transcriptional start site had several estrogen receptor binding consensus sequences., [RefSeq, PubMed]; FBXO45 promotes the proteasome-dependent degradation of p73., [RefSeq, PubMed]; Fbxo45 facilitates pancreatic carcinoma progression by targeting USP49 for ubiquitination and degradation. Publication Status: Online-Only, [RefSeq, PubMed]; Fbxo45 is the substrate-receptor subunit of a functional E3 ligase for Par-4 that has a critical role in cancer cell survival., [RefSeq, PubMed]; Fbxo45-mediated NP-STEP46 degradation via K6-linked ubiquitination sustains ERK activity in lung cancer., [RefSeq, PubMed]; LncRNA MEG8 ameliorates Parkinson's disease neuro-inflammation through miR-485-3p/FBXO45 axis., [RefSeq, PubMed]; Members of the F-box protein family, such as FBXO45, are characterized by an approximately 40-amino acid F-box motif. SCF complexes, formed by SKP1 (MIM 601434), cullin (see CUL1; MIM 603134), and F-box proteins, act as protein-ubiquitin ligases. F-box proteins interact with SKP1 through the F box, and they interact with ubiquitination targets through other protein interaction domains (summary by Jin et al., 2004 [PubMed 15520277]).[supplied by OMIM, Jan 2011]., [RefSeq]; Study found that the R108C mutation in FBXO45 is a rare variant with a modest effect on schizophrenia risk that may disrupt the structure and function of the FBXO45 protein, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
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        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NF90;D3DXB5",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005576 extracellular region;GO:0005654 nucleoplasm;GO:0005737 cytoplasm;GO:0014069 postsynaptic density",
        "go_biological_process": "GO:0051124 synaptic assembly at neuromuscular junction;GO:0006974 DNA damage response;GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process;GO:0016567 protein ubiquitination;GO:0006511 ubiquitin-dependent protein catabolic process",
        "synthesized_glycan_count": 0,
        "hit_score": 3.1,
        "record_id": "P0C2W1-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "O43155-1",
        "uniprot_id": [
            {
                "id": "FLRT2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/O43155",
                "type": "external"
            }
        ],
        "mass": 74049.0,
        "length": 660,
        "protein_name": "Leucine-rich repeat transmembrane protein FLRT2",
        "gene_name": "FLRT2",
        "organism": "Human",
        "refseq_name": "leucine-rich repeat transmembrane protein FLRT2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001333072",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001333072",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FLRT2; KIAA0405; PRO265",
        "gene_names_refseq": "FLRT2",
        "protein_names_uniprotkb": "Leucine-rich repeat transmembrane protein FLRT2; Fibronectin-like domain-containing leucine-rich transmembrane protein 2",
        "protein_names_refseq": "fibronectin-like domain-containing leucine-rich transmembrane protein 2; leucine-rich repeat transmembrane protein FLRT2 precursor; leucine-rich repeat transmembrane protein FLRT2",
        "tax_id": 9606,
        "disease": "hypertension (Disease Ontology:DOID:10763); gastric ulcer (Disease Ontology:DOID:10808); vascular dementia (Disease Ontology:DOID:8725)",
        "pathway": " (hsa:23768);  (R-HSA-5654687)",
        "pathway_count": 2,
        "publication_count": 22,
        "publication_id_list": "10644439;11237011;12975309;14688794;15340161;16872596;19159218;19834535;20421966;25892735;26890304;28325946;30429286;30459171;31844290;32938616;33968037;34019948;34405274;35051231;37480224;38587072",
        "class_list": "",
        "function": "FLRT2 prevents endothelial cell senescence and vascular aging by regulating the ITGB4/mTORC2/p53 signaling pathway. Publication Status: Online-Only, [RefSeq, PubMed]; FLRT2 suppresses bladder cancer progression through inducing ferroptosis., [RefSeq, PubMed]; Functions in cell-cell adhesion, cell migration and axon guidance. Mediates cell-cell adhesion via its interactions with ADGRL3 and probably also other latrophilins that are expressed at the surface of adjacent cells. May play a role in the migration of cortical neurons during brain development via its interaction with UNC5D. Mediates axon growth cone collapse and plays a repulsive role in neuron guidance via its interaction with UNC5D, and possibly also other UNC-5 family members. Plays a role in fibroblast growth factor-mediated signaling cascades. Required for normal organization of the cardiac basement membrane during embryogenesis, and for normal embryonic epicardium and heart morphogenesis., [UniProtKB, UniProtKB]; OPCML and FLRT2 were further validated in an independent cohort consisting of 20 low-Gleason and 33 high-Gleason tissues. We then compared patients with biochemical recurrence (n=70) vs. those without (n=86) in a third cohort, and they showed no difference in methylation at these DMR loci, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed]; Taken together, these results provide insights into the role of FLRT2 as a novel tumor suppressor in the breast, which is inactivated by hypermethylation during tumor development. Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the fibronectin leucine rich transmembrane (FLRT) family of cell adhesion molecules, which regulate early embryonic vascular and neural development. The encoded type I transmembrane protein has an extracellular region consisting of an N-terminal leucine-rich repeat domain and a type 3 fibronectin domain, followed by a transmembrane domain and a short C-terminal cytoplasmic tail domain. It functions as both a homophilic cell adhesion molecule and a heterophilic chemorepellent through its interaction with members of the uncoordinated-5 receptor family. Proteolytic removal of the extracellular region controls the migration of neurons in the developing cortex. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]., [RefSeq]",
        "predicted_glycosites": 5,
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        "reported_n_glycosites_with_glycan": 0,
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        "reported_phosphosites": 0,
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        "reported_snv": 70,
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        "biomarker_type": "",
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        "secondary_ac_list": "A0AV84;B7ZLP3",
        "ec_number_list": [],
        "go_molecular_function": "GO:0030674 protein-macromolecule adaptor activity;GO:0045499 chemorepellent activity;GO:0005104 fibroblast growth factor receptor binding",
        "go_cellular_component": "GO:0098978 glutamatergic synapse;GO:0005615 extracellular space;GO:0005886 plasma membrane;GO:0005911 cell-cell junction;GO:0005925 focal adhesion",
        "go_biological_process": "GO:0003007 heart morphogenesis;GO:0008543 fibroblast growth factor receptor signaling pathway;GO:0071711 basement membrane organization;GO:0061343 cell adhesion involved in heart morphogenesis",
        "synthesized_glycan_count": 0,
        "hit_score": 2.8,
        "record_id": "O43155-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000011000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "P31994-1",
        "uniprot_id": [
            {
                "id": "FCG2B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/P31994",
                "type": "external"
            }
        ],
        "mass": 34044.0,
        "length": 310,
        "protein_name": "Low affinity immunoglobulin gamma Fc region receptor II-b",
        "gene_name": "FCGR2B",
        "organism": "Human",
        "refseq_name": "low affinity immunoglobulin gamma Fc region receptor II-b isoform 2 precursor",
        "refseq_ac": [
            {
                "id": "NP_001002273",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002273",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FCGR2B; CD32; FCG2; IGFR2",
        "gene_names_refseq": "CD32B; CD32; FCG2; FCGR2B; FCGR2; IGFR2",
        "protein_names_uniprotkb": "Low affinity immunoglobulin gamma Fc region receptor II-b; CDw32; Fc-gamma RII-b; Fc-gamma-RIIb; FcRII-b; IgG Fc receptor II-b",
        "protein_names_refseq": "CDw32; Fc fragment of IgG receptor IIb; Fc fragment of IgG, low affinity II, receptor for (CD32); Fc fragment of IgG, low affinity IIb, receptor (CD32); Fc fragment of IgG, low affinity IIb, receptor for (CD32); Fc gamma RIIb; fc-gamma RII-b; fc-gamma-RIIb; fcRII-b; igG Fc receptor II-b; low affinity immunoglobulin gamma Fc region receptor II-b isoform 2 precursor; low affinity immunoglobulin gamma Fc region receptor II-b",
        "tax_id": 9606,
        "disease": "lymphoid leukemia (Disease Ontology:DOID:1037); malaria (Disease Ontology:DOID:12365); glomerulonephritis (Disease Ontology:DOID:2921); end stage renal disease (Disease Ontology:DOID:783); autoimmune thrombocytopenic purpura (Disease Ontology:DOID:8924); systemic lupus erythematosus (Disease Ontology:DOID:9074); malaria, susceptibility to (MONDO:MONDO:0021024)",
        "pathway": " (hsa:2213);  (R-HSA-198933)",
        "pathway_count": 2,
        "publication_count": 149,
        "publication_id_list": "10064577;10382761;10499918;10746781;11265639;11489943;11513152;11556966;11807247;11857637;11858820;11861603;11955593;11955595;11955599;12115230;12213321;12483297;12588680;14719373;14970179;15034010;15136729;15155468;15187158;15304001;15534202;15541655;15580655;15607800;15778510;15781451;15800062;15851719;15864273;15914856;16014749;16091383;16129954;16339513;16380601;16551255;16737824;16754721;16893496;16904340;16928187;17045824;17057721;17237375;17337780;17435165;18031695;18037897;18055229;18209062;18234675;18593354;19149696;19359216;19592130;20166139;20385827;20730098;21081667;21241660;2142460;21654843;21800138;21841309;21877119;22396535;23481700;23695528;23929856;24190977;24305946;24715725;2529342;2531080;25345863;25502872;25505266;25703557;25716998;26284469;26300885;26375851;27452731;27600516;27726376;27846572;28228285;28467828;28566370;28649982;28832583;28834231;28904123;29242379;29508533;29557506;29632711;29786170;29789417;30315122;30429286;30524438;30573663;31154438;31217245;31611695;31844290;32162841;32350084;32357974;33043033;33298915;33409482;33691108;33968037;34357683;34561969;34932366;35154160;35251023;35580925;36010968;37421619;37611081;37634276;37713871;37844994;38147316;7531291;7542404;8178173;8327512;8466861;8577729;8756631;8995416;9148918;9232445;9285412;9314561;9603468;9700512;9730896",
        "class_list": "",
        "function": "C-reactive protein impairs immune response of CD8[+] T cells via FcgammaRIIb-p38MAPK-ROS axis in multiple myeloma. Erratum:[J Immunother Cancer. 2023 Dec 14;11(12):e007593corr1. doi: 10.1136/jitc-2023-007593corr1. PMID: 38101865], [RefSeq, PubMed]; FCGR2B as a prognostic and immune microenvironmental marker for gliomas based on transcriptomic analysis., [RefSeq, PubMed]; FcgammaRIIB Is an Immune Checkpoint Limiting the Activity of Treg-Targeting Antibodies in the Tumor Microenvironment., [RefSeq, PubMed]; FcgammaRIIB expressed on CD8[+] T cells limits responsiveness to PD-1 checkpoint inhibition in cancer., [RefSeq, PubMed]; FcgammaRIIB expression increases during primary biliary cholangitis., [RefSeq, PubMed]; Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis., [UniProtKB]; The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 1,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "mined_o_glycosites": 0,
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        "reported_n_glycosites": 4,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 5,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 5,
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        "reported_fully_resolved_glycans": 9,
        "reported_phosphosites": 4,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 23,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 38,
        "disease_count": 7,
        "glyco_site_count": 5,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6H8N3;O95649;Q53X85;Q5VXA9;Q8NIA1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0001540 amyloid-beta binding;GO:0044877 protein-containing complex binding;GO:0019864 IgG binding;GO:0019770 IgG receptor activity;GO:0019772 low-affinity IgG receptor activity",
        "go_cellular_component": "GO:0005886 plasma membrane;GO:0043197 dendritic spine;GO:0009897 external side of plasma membrane;GO:0044297 cell body",
        "go_biological_process": "GO:0038094 Fc-gamma receptor signaling pathway;GO:0032693 negative regulation of interleukin-10 production;GO:0006952 defense response;GO:0006954 inflammatory response;GO:0007166 cell surface receptor signaling pathway",
        "synthesized_glycan_count": 0,
        "hit_score": 19.3,
        "record_id": "P31994-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000000001001.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q14314-1",
        "uniprot_id": [
            {
                "id": "FGL2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q14314",
                "type": "external"
            }
        ],
        "mass": 50229.0,
        "length": 439,
        "protein_name": "Fibroleukin",
        "gene_name": "FGL2",
        "organism": "Human",
        "refseq_name": "fibroleukin precursor",
        "refseq_ac": [
            {
                "id": "NP_006673",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_006673",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FGL2",
        "gene_names_refseq": "FGL2; T49; pT49",
        "protein_names_uniprotkb": "Fibroleukin; Fibrinogen-like protein 2; pT49",
        "protein_names_refseq": "fibrinogen-like protein 2; fibroleukin precursor; fibroleukin",
        "tax_id": 9606,
        "disease": "autoimmune glomerulonephritis (Disease Ontology:DOID:0040094); episodic ataxia type 6 (Disease Ontology:DOID:0050994); dicarboxylic aminoaciduria (Disease Ontology:DOID:0060650); schizophrenia 18 (Disease Ontology:DOID:0070093); neurodegenerative disease (Disease Ontology:DOID:1289); low tension glaucoma (Disease Ontology:DOID:13544); epilepsy (Disease Ontology:DOID:1826); multiple system atrophy (Disease Ontology:DOID:4752)",
        "pathway": " (hsa:10875);  (R-HSA-6798695)",
        "pathway_count": 2,
        "publication_count": 37,
        "publication_id_list": "16335952;19159218;23650620;23719902;24190977;25892735;26154972;27397612;27862975;28467828;28832583;29242379;29391424;29557506;29632711;29741879;29769354;30429286;30459171;31154438;32350084;32983136;33043033;33091337;33717175;35051231;35580925;36243222;36284347;36581221;36671474;37074911;37200306;38902261;7642106;8692836;9647217",
        "class_list": "",
        "function": "A homozygous truncating mutation of FGL2 is associated with immune dysregulation., [RefSeq, PubMed]; Assessment of Fibrinogen-like 2 (FGL2) in Human Chronic Kidney Disease through Transcriptomics Data Analysis. Publication Status: Online-Only, [RefSeq, PubMed]; CD8[+] T cell-derived Fgl2 regulates immunity in a cell-autonomous manner via ligation of FcgammaRIIB. Publication Status: Online-Only, [RefSeq, PubMed]; May play a role in physiologic lymphocyte functions at mucosal sites., [UniProtKB]; Presence and activity of Fibrinogen like protein 2 in platelets. Publication Status: Online-Only, [RefSeq, PubMed]; The protein encoded by this gene is a secreted protein that is similar to the beta- and gamma-chains of fibrinogen. The carboxyl-terminus of the encoded protein consists of the fibrinogen-related domains (FRED). The encoded protein forms a tetrameric complex which is stabilized by interchain disulfide bonds. This protein may play a role in physiologic functions at mucosal sites. [provided by RefSeq, Jul 2008]., [RefSeq]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
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        "reported_n_glycosites": 4,
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        "reported_c_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 4,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
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        "total_reported_n_glycosites": 4,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 4,
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        "reported_snv": 19,
        "reported_interactions": 0,
        "missing_score": 3939,
        "biomarker_type": "",
        "glycan_count": 125,
        "disease_count": 8,
        "glyco_site_count": 7,
        "binding_glycan_count": 0,
        "secondary_ac_list": "",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome;GO:1904813 ficolin-1-rich granule lumen",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 16.9,
        "record_id": "Q14314-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1100000010000.101.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q15485-1",
        "uniprot_id": [
            {
                "id": "FCN2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q15485",
                "type": "external"
            }
        ],
        "mass": 34001.0,
        "length": 313,
        "protein_name": "Ficolin-2",
        "gene_name": "FCN2",
        "organism": "Human",
        "refseq_name": "ficolin-2 isoform a precursor",
        "refseq_ac": [
            {
                "id": "NP_004099",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_004099",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FCN2; FCNL",
        "gene_names_refseq": "EBP-37; FCN2; FCNL; P35; ficolin-2",
        "protein_names_uniprotkb": "Ficolin-2; 37 kDa elastin-binding protein; Collagen/fibrinogen domain-containing protein 2; EBP-37; Ficolin-B; Ficolin-beta; Hucolin; L-ficolin; Serum lectin p35",
        "protein_names_refseq": "37 kDa elastin-binding protein; L-ficolin; collagen/fibrinogen domain-containing protein 2; ficolin (collagen/fibrinogen domain containing lectin) 2 (hucolin); ficolin B; ficolin-2 isoform a precursor; ficolin-beta; serum lectin p35",
        "tax_id": 9606,
        "disease": "spinocerebellar ataxia 1 (Disease Ontology:DOID:0050954); autosomal dominant cerebellar ataxia (Disease Ontology:DOID:1441)",
        "pathway": " (hsa:2220);  (R-HSA-166662);  (R-HSA-166663);  (R-HSA-2855086)",
        "pathway_count": 4,
        "publication_count": 60,
        "publication_id_list": "10639434;10679061;10925294;11012776;11532276;11907111;12367778;12396008;14280442;14702039;14707097;15078867;15164053;15199963;15489334;15728497;15804047;16116205;16959974;17215869;17897951;17938215;18343499;18596036;20032467;20375619;20375634;20400674;21730084;22238349;23460739;24715725;25344472;25447524;26173080;26811146;29242379;29557506;31154438;31638993;31852794;32088336;32094208;32601370;33936100;34529517;36499663;36805857;36833169;38033168;6019133;70787;7391573;7498469;8538770;8576206;8586615;8884275;9202708;9777405",
        "class_list": "glycogene",
        "function": "Association of the FCN2 Gene Promoter Region Polymorphisms with Very Low Birthweight in Preterm Neonates. Publication Status: Online-Only, [RefSeq, PubMed]; Calcium-dependent lectin, which acts as a pattern recognition receptor that initiates the lectin pathway of the complement system, a cascade of proteins that leads to phagocytosis and breakdown of pathogens and signaling that strengthens the adaptive immune system (PubMed:10679061, PubMed:14707097, PubMed:15804047, PubMed:17215869, PubMed:25344472, PubMed:8576206). Specifically recognizes and binds carbohydrates on the pathogen surface, activating the MASP1 serine protease and initiating the proteolytic cascade of the lectin complement pathway (PubMed:14707097). Specifically binds N-Acetylglucosamine (GlcNAc), as well as phosphocholine and lipoteichoic acid moieties on the surface of pathogens (PubMed:14707097, PubMed:17215869, PubMed:25344472, PubMed:8576206). Enhances phagocytosis of S.typhimurium by neutrophils, suggesting an opsonic effect (PubMed:8576206)., [UniProtKB, PubMed, PubMed, PubMed, PubMed, PubMed, PubMed]; L-ficolin-MASP arm of the complement system in schizophrenia., [RefSeq, PubMed]; Selected SNPs of FCN2 Associated with Chronic Tonsillitis in the Polish Adult Population. Publication Status: Online-Only, [RefSeq, PubMed]; The product of this gene belongs to the ficolin family of proteins. This family is characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. This gene is predominantly expressed in the liver, and has been shown to have carbohydrate binding and opsonic activities. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]., [RefSeq]; Variants of IL6, IL10, FCN2, RNASE3, IL12B and IL17B loci are associated with Schistosoma mansoni worm burden in the Albert Nile region of Uganda. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 1,
        "predicted_n_glycosites": 1,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 1,
        "mined_n_glycosites": 1,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 1,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 2,
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        "reported_glycation": 0,
        "reported_snv": 473,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 2,
        "glyco_site_count": 3,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A6NFG7;A8K478;Q6IS69;Q7M4P4;Q9UC57",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005102 signaling receptor binding;GO:0046872 metal ion binding;GO:0048306 calcium-dependent protein binding;GO:0043394 proteoglycan binding;GO:0070892 lipoteichoic acid immune receptor activity",
        "go_cellular_component": "GO:0005576 extracellular region;GO:0005615 extracellular space;GO:0031012 extracellular matrix;GO:0070062 extracellular exosome;GO:0072562 blood microparticle",
        "go_biological_process": "GO:0006508 proteolysis;GO:0050829 defense response to Gram-negative bacterium;GO:0050830 defense response to Gram-positive bacterium;GO:0001867 complement activation, lectin pathway;GO:1903028 positive regulation of opsonization",
        "synthesized_glycan_count": 0,
        "hit_score": 6.3,
        "record_id": "Q15485-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.1000100010000.111.10000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q63HN1-1",
        "uniprot_id": [
            {
                "id": "S31F2_HUMAN",
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                "type": "external"
            }
        ],
        "mass": 61860.0,
        "length": 556,
        "protein_name": "Putative protein SPATA31F2P",
        "gene_name": "SPATA31F2P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "SPATA31F2P; C9orf144A; C9orf144; FAM205BP; FAM205B",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative protein SPATA31F2P; Putative protein FAM205B",
        "protein_names_refseq": "",
        "tax_id": 9606,
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        "missing_score": 10000,
        "biomarker_type": "",
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        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6ZRJ7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.1,
        "record_id": "Q63HN1-1",
        "record_type": "protein",
        "filter_code": "0000000.0000000.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q658T7-1",
        "uniprot_id": [
            {
                "id": "F90A2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q658T7",
                "type": "external"
            }
        ],
        "mass": 50084.0,
        "length": 463,
        "protein_name": "Putative protein FAM90A2P",
        "gene_name": "FAM90A2P",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "FAM90A2P",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative protein FAM90A2P",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "28411811",
        "class_list": "",
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        "predicted_glycosites": 0,
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    },
    {
        "uniprot_canonical_ac": "Q6BAA4-1",
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            {
                "id": "FCRLB_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6BAA4",
                "type": "external"
            }
        ],
        "mass": 46904.0,
        "length": 426,
        "protein_name": "Fc receptor-like B",
        "gene_name": "FCRLB",
        "organism": "Human",
        "refseq_name": "Fc receptor-like B isoform 1 precursor",
        "refseq_ac": [
            {
                "id": "NP_001002901",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001002901",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FCRLB; FCRL2; FCRLM2; FCRY; FREB2",
        "gene_names_refseq": "FCRL2; FCRLB; FCRLM2; FCRLY; FREB-2; FREB2; FcRY",
        "protein_names_uniprotkb": "Fc receptor-like B; FREB-2; Fc receptor homolog expressed in B-cells protein 2; Fc receptor-like and mucin-like protein 2; Fc receptor-like protein 2; Fc receptor-related protein Y; FcRY",
        "protein_names_refseq": "Fc receptor-like B isoform 1 precursor; fc receptor homolog expressed in B cells protein 2; fc receptor-like and mucin-like protein 2; fc receptor-like protein 2; fc receptor-related protein Y",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:127943)",
        "pathway_count": 1,
        "publication_count": 18,
        "publication_id_list": "15551350;15676285;15815692;16263223;17975119;19023099;23593433;24190977;25418920;27920218;28904123;31530632;31844290;32157095;32938616;33298915;33717175;35051231",
        "class_list": "",
        "function": "Expression analysis revealed FCRL2 mRNA only in placenta.FCRL2 is differentially expressed by transformed B cell lines., [RefSeq, PubMed]; FCRL2 belongs to the Fc receptor family. Fc receptors are involved in phagocytosis, antibody-dependent cell cytotoxicity, immediate hypersensitivity, and transcytosis of immunoglobulins via their ability to bind immunoglobulin (Ig) constant regions (Chikaev et al., 2005 [PubMed 15676285]).[supplied by OMIM, Mar 2008]., [RefSeq]; Fcry is upregulated by short-term treatment with BAFF/BLyS, which promotes B cell survival rather than proliferation, [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator), [RefSeq, PubMed, PubMed]; The aim of the study was to associate multiple polymorphisms within FCGR gene locus with IgA nephropathy in a large Chinese cohort. Publication Status: Online-Only, [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 1,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 1,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 1,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 6,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "A2A3J5;A2A3J7;Q5VXA6;Q6BAA0;Q6BAA1;Q6BAA2;Q6BAA3;Q8IXZ7",
        "ec_number_list": [],
        "go_molecular_function": "GO:0004888 transmembrane signaling receptor activity",
        "go_cellular_component": "GO:0005737 cytoplasm;GO:0005783 endoplasmic reticulum;GO:0005829 cytosol;GO:0009897 external side of plasma membrane",
        "go_biological_process": "GO:0007166 cell surface receptor signaling pathway;GO:0016064 immunoglobulin mediated immune response",
        "synthesized_glycan_count": 0,
        "hit_score": 2.0,
        "record_id": "Q6BAA4-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.1000000000000.100.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6NSW5-1",
        "uniprot_id": [
            {
                "id": "DE10B_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6NSW5",
                "type": "external"
            }
        ],
        "mass": 40514.0,
        "length": 357,
        "protein_name": "Putative DENN domain-containing protein 10 B",
        "gene_name": "DENND10P1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "DENND10P1; FAM45BP; FAM45; HT011",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative DENN domain-containing protein 10 B; DENND10 pseudogene 1; Putative protein FAM45B",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 6,
        "publication_id_list": "10931946;28510447;30779550;30833945;33981976;34357683",
        "class_list": "",
        "function": "May be a guanine nucleotide exchange factor (GEF)., [UniProtKB, UniProtKB]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 1,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 1,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 1,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q5H9G7;Q9NZ36",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005085 guanyl-nucleotide exchange factor activity;GO:0031267 small GTPase binding",
        "go_cellular_component": "GO:0005770 late endosome",
        "go_biological_process": "GO:2000641 regulation of early endosome to late endosome transport;GO:0015031 protein transport",
        "synthesized_glycan_count": 0,
        "hit_score": 0.9,
        "record_id": "Q6NSW5-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0100000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6P4F2-1",
        "uniprot_id": [
            {
                "id": "FDX2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6P4F2",
                "type": "external"
            }
        ],
        "mass": 19521.0,
        "length": 183,
        "protein_name": "Ferredoxin-2, mitochondrial",
        "gene_name": "FDX2",
        "organism": "Human",
        "refseq_name": "ferredoxin-2, mitochondrial",
        "refseq_ac": [
            {
                "id": "NP_001384335",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001384335",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FDX2; FDX1L",
        "gene_names_refseq": "FDX1L; FDX2; MEOAL",
        "protein_names_uniprotkb": "Ferredoxin-2, mitochondrial; Adrenodoxin-like protein; Ferredoxin-1-like protein",
        "protein_names_refseq": "adrenodoxin-like protein, mitochondrial; ferredoxin 1 like; ferredoxin-2, mitochondrial",
        "tax_id": 9606,
        "disease": "episodic mitochondrial myopathy with optic atrophy and reversible leukoencephalopathy (Disease Ontology:DOID:0070734)",
        "pathway": " (hsa:112812);  (R-HSA-1362409);  (R-HSA-196108);  (R-HSA-211976);  (R-HSA-2395516);  (R-HSA-5579026)",
        "pathway_count": 6,
        "publication_count": 75,
        "publication_id_list": "10588945;10639125;11237011;11502818;11555828;11823441;12785837;12886008;12947415;12970193;15042513;15507506;15509595;1567230;15952888;16847322;1708392;17331979;1741400;18319250;18339629;18425540;19454487;19661213;20149798;20522547;20547883;20668094;20873749;20877624;21159840;21298097;21636783;21776984;21944046;21987576;22077971;22101253;22306468;22323289;22352884;22511353;2256920;22772592;23208207;24281368;24733926;25347204;25418920;25542846;25818881;2592361;26016389;26016518;27989128;28001042;28832583;29097656;29242379;2981667;3001071;30010796;3024157;3038528;31848261;3487786;36280795;38425362;39467201;8307574;8619637;8645003;9536209;9578606;9915832",
        "class_list": "",
        "function": "Electron donor, of the core iron-sulfur cluster (ISC) assembly complex, that acts to reduce the persulfide into sulfide during [2Fe-2S] clusters assembly on the scaffolding protein ISCU (PubMed:28001042). The core iron-sulfur cluster (ISC) assembly complex is involved in the de novo synthesis of a [2Fe-2S] cluster, the first step of the mitochondrial iron-sulfur protein biogenesis (By similarity). This process is initiated by the cysteine desulfurase complex (NFS1:LYRM4:NDUFAB1) that produces persulfide which is delivered on the scaffold protein ISCU in a FXN-dependent manner (By similarity). Then this complex is stabilized by FDX2 which provides reducing equivalents to accomplish the [2Fe-2S] cluster assembly (By similarity). Finally, the [2Fe-2S] cluster is transferred from ISCU to chaperone proteins, including HSCB, HSPA9 and GLRX5 (By similarity). Essential for coenzyme Q biosynthesis: together with FDXR, transfers the electrons required for the hydroxylation reaction performed by COQ6 (PubMed:38425362)., [UniProtKB, PubMed, UniProtKB, PubMed]; Functional spectrum and specificity of mitochondrial ferredoxins FDX1 and FDX2., [RefSeq, PubMed]; Observational study of gene-disease association. (HuGE Navigator) Publication Status: Online-Only, [RefSeq, PubMed]; This gene encodes a member of the ferredoxin family. The encoded protein contains a 2Fe-2S ferredoxin-type domain and is essential for heme A and Fe/S protein biosynthesis. Mutation in FDX1L gene is associated with mitochondrial muscle myopathy. [provided by RefSeq, Sep 2014]., [RefSeq]; Unique conformational change is observed when holo hFd2 is warmed to physiological temperatures, or higher, [RefSeq, PubMed]; Unraveling the molecular determinants of a rare human mitochondrial disorder caused by the P144L mutation of FDX2., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 1,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 1,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B7Z6L7;Q8N8B8",
        "ec_number_list": [],
        "go_molecular_function": "GO:0009055 electron transfer activity;GO:0046872 metal ion binding;GO:0051537 2 iron, 2 sulfur cluster binding",
        "go_cellular_component": "GO:0005739 mitochondrion;GO:0005759 mitochondrial matrix",
        "go_biological_process": "GO:0016226 iron-sulfur cluster assembly;GO:0006744 ubiquinone biosynthetic process;GO:0022900 electron transport chain;GO:0044571 [2Fe-2S] cluster assembly;GO:0140647 P450-containing electron transport chain",
        "synthesized_glycan_count": 0,
        "hit_score": 7.6,
        "record_id": "Q6P4F2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6PIJ6-1",
        "uniprot_id": [
            {
                "id": "FBX38_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6PIJ6",
                "type": "external"
            }
        ],
        "mass": 133944.0,
        "length": 1188,
        "protein_name": "F-box only protein 38",
        "gene_name": "FBXO38",
        "organism": "Human",
        "refseq_name": "F-box only protein 38 isoform c",
        "refseq_ac": [
            {
                "id": "NP_001258652",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001258652",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FBXO38; SP329",
        "gene_names_refseq": "FBXO38; Fbx38; HMN2D; HMND6; MOKA; SP329",
        "protein_names_uniprotkb": "F-box only protein 38",
        "protein_names_refseq": "F-box only protein 38 isoform c; F-box only protein 38; modulator of KLF7 activity homolog",
        "tax_id": 9606,
        "disease": "autosomal dominant distal hereditary motor neuronopathy 6 (Disease Ontology:DOID:0111210)",
        "pathway": " (hsa:81545)",
        "pathway_count": 1,
        "publication_count": 66,
        "publication_id_list": "14729953;15498874;19690332;23186163;24207122;24366607;24715725;25418920;25576301;25645385;26154972;26375851;26643602;26929215;26992070;27600516;27846572;27920218;28228285;28832583;28834231;28904123;29242379;29393594;29493099;29508533;29557506;29632046;29632711;30315122;30379171;30429286;30487606;30779550;31844290;32157095;32357974;32387766;32488085;32502341;32938616;32983136;33123756;33298915;33537174;33592498;33717175;33912179;33936100;33968037;34087483;34105348;34171305;34185709;34211107;34932366;35051231;35561310;35580925;36010968;36241641;36284347;37821621;37938771;38277817;38823119",
        "class_list": "",
        "function": "FBXO38 deficiency promotes lysosome-dependent STING degradation and inhibits cGAS-STING pathway activation., [RefSeq, PubMed]; FBXO38 regulates macrophage polarization to control the development of cancer and colitis., [RefSeq, PubMed]; Identification of rare variants in the FBXO38 gene of patients with chronic inflammatory demyelinating polyradiculoneuropathy., [RefSeq, PubMed]; Our findings provide direct evidence for the association of FBXO38 and AP3B2 with severe chronic periodontitis in the Han Chinese population. Publication Status: Online-Only, [RefSeq, PubMed]; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of PDCD1/PD-1, thereby regulating T-cells-mediated immunity (PubMed:30487606). Required for anti-tumor activity of T-cells by promoting the degradation of PDCD1/PD-1; the PDCD1-mediated inhibitory pathway being exploited by tumors to attenuate anti-tumor immunity and facilitate tumor survival (PubMed:30487606). May indirectly stimulate the activity of transcription factor KLF7, a regulator of neuronal differentiation, without promoting KLF7 ubiquitination (By similarity)., [UniProtKB, UniProtKB, PubMed]; This gene encodes a large protein that contains an F-box domain and may participate in protein ubiquitination. The encoded protein is a transcriptional co-activator of Krueppel-like factor 7 (Klf7). A heterozygous mutation in this gene was found in individuals with autosomal dominant distal hereditary motor neuronopathy type IID. There is a pseudogene for this gene on chromosome 4. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2013]., [RefSeq]; This publication identifies the F-box protein 38 mouse ortholog and characterizes its interaction with KLF7 during regulation of cell cycle progression., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 2,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 2,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 2,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 1,
        "reported_phosphosites": 6,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 21,
        "reported_interactions": 0,
        "missing_score": 0,
        "biomarker_type": "",
        "glycan_count": 1,
        "disease_count": 1,
        "glyco_site_count": 1,
        "binding_glycan_count": 0,
        "secondary_ac_list": "Q6PK72;Q7Z2U0;Q86VN3;Q9BXY6;Q9H837;Q9HC40",
        "ec_number_list": [],
        "go_molecular_function": "GO:1990756 ubiquitin-like ligase-substrate adaptor activity",
        "go_cellular_component": "GO:0005634 nucleus;GO:0005737 cytoplasm;GO:0005829 cytosol;GO:0019005 SCF ubiquitin ligase complex",
        "go_biological_process": "GO:0002842 positive regulation of T cell mediated immune response to tumor cell;GO:0010976 positive regulation of neuron projection development;GO:0002250 adaptive immune response;GO:0070936 protein K48-linked ubiquitination;GO:0050870 positive regulation of T cell activation",
        "synthesized_glycan_count": 0,
        "hit_score": 7.0,
        "record_id": "Q6PIJ6-1",
        "record_type": "protein",
        "filter_code": "0000000.1000111.010000.000000000001000000.0100000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6UWF9-1",
        "uniprot_id": [
            {
                "id": "F180A_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6UWF9",
                "type": "external"
            }
        ],
        "mass": 19733.0,
        "length": 173,
        "protein_name": "Protein FAM180A",
        "gene_name": "FAM180A",
        "organism": "Human",
        "refseq_name": "protein FAM180A precursor",
        "refseq_ac": [
            {
                "id": "NP_995327",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_995327",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "FAM180A; PRO4423",
        "gene_names_refseq": "FAM180A; UNQ1940",
        "protein_names_uniprotkb": "Protein FAM180A",
        "protein_names_refseq": "HWKM1940; protein FAM180A precursor; protein FAM180A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:389558)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "12975309;24715725;30429286;32157095",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
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        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
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        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
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        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 3,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RP85",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0005576 extracellular region",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q6UWF9-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q6ZSG2-1",
        "uniprot_id": [
            {
                "id": "INSY2_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q6ZSG2",
                "type": "external"
            }
        ],
        "mass": 52909.0,
        "length": 479,
        "protein_name": "Inhibitory synaptic factor 2A",
        "gene_name": "INSYN2A",
        "organism": "Human",
        "refseq_name": "inhibitory synaptic factor 2A",
        "refseq_ac": [
            {
                "id": "NP_001034851",
                "url": "https://www.ncbi.nlm.nih.gov/protein/NP_001034851",
                "type": "external"
            }
        ],
        "gene_names_uniprotkb": "INSYN2A; C10orf141; FAM196A; INSYN2",
        "gene_names_refseq": "C10orf141; FAM196A; INSYN2A; INSYN2",
        "protein_names_uniprotkb": "Inhibitory synaptic factor 2A; InSyn2",
        "protein_names_refseq": "family with sequence similarity 196 member A; inhibitory synaptic factor 2A; inhibitory synaptic protein 2; protein FAM196A",
        "tax_id": 9606,
        "disease": "",
        "pathway": " (hsa:642938)",
        "pathway_count": 1,
        "publication_count": 4,
        "publication_id_list": "30779550;34252586;35051231;36215666",
        "class_list": "",
        "function": "Component of the protein machinery at the inhibitory synapses, probably acting as a scaffold. Inhibitory synapses dampen neuronal activity through postsynaptic hyperpolarization. This synaptic inhibition is fundamental for the functioning of the central nervous system, shaping and orchestrating the flow of information through neuronal networks to generate a precise neural code., [UniProtKB, UniProtKB]; Further refining the critical region of 10q26 microdeletion syndrome: A possible involvement of INSYN2 and NPS in the cognitive phenotype., [RefSeq, PubMed]",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 1,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 4,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2RNT4;B7ZME7",
        "ec_number_list": [],
        "go_molecular_function": "",
        "go_cellular_component": "GO:0014069 postsynaptic density",
        "go_biological_process": "GO:0060080 inhibitory postsynaptic potential",
        "synthesized_glycan_count": 0,
        "hit_score": 0.5,
        "record_id": "Q6ZSG2-1",
        "record_type": "protein",
        "filter_code": "0000000.1000101.100000.000000000001000000.0000000000001.000.00000",
        "kg_view_protein": true
    },
    {
        "uniprot_canonical_ac": "Q75LS8-1",
        "uniprot_id": [
            {
                "id": "FKB9L_HUMAN",
                "url": "https://www.uniprot.org/uniprot/Q75LS8",
                "type": "external"
            }
        ],
        "mass": 15591.0,
        "length": 142,
        "protein_name": "Putative FK506-binding protein 9-like protein",
        "gene_name": "FKBP9P1",
        "organism": "Human",
        "refseq_name": "",
        "refseq_ac": [],
        "gene_names_uniprotkb": "FKBP9P1; FKBP9L",
        "gene_names_refseq": "",
        "protein_names_uniprotkb": "Putative FK506-binding protein 9-like protein; FK506-binding protein 9-like protein pseudogene",
        "protein_names_refseq": "",
        "tax_id": 9606,
        "disease": "",
        "pathway": "",
        "pathway_count": 0,
        "publication_count": 1,
        "publication_id_list": "30429286",
        "class_list": "",
        "function": "",
        "predicted_glycosites": 0,
        "predicted_n_glycosites": 0,
        "predicted_o_glycosites": 0,
        "predicted_c_glycosites": 0,
        "predicted_s_glycosites": 0,
        "mined_glycosites": 0,
        "mined_n_glycosites": 0,
        "mined_o_glycosites": 0,
        "mined_c_glycosites": 0,
        "mined_s_glycosites": 0,
        "reported_n_glycosites": 0,
        "reported_o_glycosites": 0,
        "reported_c_glycosites": 0,
        "reported_s_glycosites": 0,
        "reported_n_glycosites_with_glycan": 0,
        "reported_o_glycosites_with_glycan": 0,
        "reported_c_glycosites_with_glycan": 0,
        "reported_s_glycosites_with_glycan": 0,
        "total_reported_n_glycosites": 0,
        "total_reported_o_glycosites": 0,
        "total_reported_c_glycosites": 0,
        "total_reported_s_glycosites": 0,
        "total_n_glycosites": 0,
        "total_o_glycosites": 0,
        "total_c_glycosites": 0,
        "total_s_glycosites": 0,
        "reported_fully_resolved_glycans": 0,
        "reported_phosphosites": 0,
        "reported_mutagensis": 0,
        "reported_glycation": 0,
        "reported_snv": 0,
        "reported_interactions": 0,
        "missing_score": 10000,
        "biomarker_type": "",
        "glycan_count": 0,
        "disease_count": 0,
        "glyco_site_count": 0,
        "binding_glycan_count": 0,
        "secondary_ac_list": "B2R7H1",
        "ec_number_list": [],
        "go_molecular_function": "GO:0005509 calcium ion binding;GO:0003755 peptidyl-prolyl cis-trans isomerase activity",
        "go_cellular_component": "GO:0005783 endoplasmic reticulum",
        "go_biological_process": "",
        "synthesized_glycan_count": 0,
        "hit_score": 0.2,
        "record_id": "Q75LS8-1",
        "record_type": "protein",
        "filter_code": "0000000.0000100.100000.000000000001000000.0000000000000.000.00000",
        "kg_view_protein": true
    }
]